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Drug Details

KEFADOL

• Drug Class Description
  Cephalosporins.
• Generic Name
  Cefamandole
• Presentation
  Powder for injection, cefamandole (as nafate) 1 g.
• Description
  Powder in vial.
• Indications
  Infections of the lower respiratory tract, genito-urinary tract, bones and joints, bloodstream (septicaemia), skin and soft tissue, gall bladder and peritoneum, and pelvic inflammatory disease in women, when due to susceptible micro- organisms.
• Adult Dosage
  500 mg - 2 g intramuscularly or intravenously four to eight hourly; maximum 12 g daily.
• Child Dosage
  Under 1 month, not recommended; over 1 month, 50 - 100 mg/kg daily in divided doses four to eight hourly; maximum 150 mg/kg daily.
• Contra Indications
  Known allergy to cephalosporins.
• Special Precautions
  Penicillin sensitivity. Impaired renal function.
• Interactions
  Loop diuretics, aminoglycosides.  Loop diuretics, aminoglycosides.
• Adverse Drug Reactions
  

  Pain at injection site, hypersensitivity reactions. GI disturbances, candidosis, eosinophilia, neutropenia, thrombocytopenia, rise in liver enzymes and blood urea. Transient hepatitis, cholestatic jaundice. Positive Coomb's test.