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Drug Details

Quinine Dihydrochloride

• Drug Class Description
  Quinine.
• Presentation
  Injection, quinine dihydrochloride 300mg/mL . For dilution and use as an infusion. 1ml and 2mL ampoules, available from Martindale (special order) or from specialist centres.
• Indications
  Treatment of falciparum malaria.
• Adult Dosage
  Refer to manufacturer's prescribing information.
• Contra Indications
  Haemoglobulinuria, optic neuritis.
• Special Precautions
  

  Atrial fibrillation, conduction defects, heart block. Blood glucose monitoring required during treatment. G6PD deficiency. Pregnancy and lactation.

• Interactions
  Halofantrine, mefloquine, cardiac glycosides, antipsychotics, cimetidine. Astemizole and terfenadine. Amiodarone, flecainide.
• Adverse Drug Reactions
  

  Hypersensitivity reactions, Hypersensitivity reactions, including pruritus, rash and flushing. Cinchonism manifest by tinnitus, headaches, nausea. Visual disturbances, including blurred vision, photophobia and, in severe cases, optic atrophy. Other central nervous system effects, including deafness, vertigo, sweating, restlessness and confusion, have also been reported. Gastrointestinal effects. Haematological effects, including thrombocytopenia, leukopenia and thrombocytopenic purpura. Rarely, agranulocytosis. Conduction disturbances, ventricular tachycardia and anginal symptoms reported. Hypoglycaemia. Acute renal failure.