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Drug Details

DDAVP

• Drug Class Description
  Vasopressin analogues.
• Generic Name
  Desmopressin acetate - endocrine
• Presentation
  DDAVP/Desmopressin Intranasal Solution: Desmopressin acetate 100 micrograms/mL. DDAVP Tablets: Desmopressin acetate 0.1 mg , 0.2 mg . DDAVP/Desmopressin Injection: Desmopressin acetate 4 micrograms/mL.
• Description
  DDAVP/Desmopressin Intranasal Solution: intranasal solution. DDAVP Tablets: white scored tablets marked with strength. DDAVP/Desmopressin Injection: ampoules.
• Indications
  DDAVP/Desmopressin Intranasal Solution: Diagnosis and treatment of vasopressin-sensitive cranial diabetes insipidus; establishing renal concentration capacity. DDAVP Tablets: Treatment of vasopressin-sensitive cranial diabetes insipidus; treatment of post-hypophysectomy polyuria/ polydipsia. DDAVP/Desmopressin Injection: Cranial diabetes insipidus.
• Adult Dosage
  

  DDAVP/Desmopressin Intranasal Solution: Diabetes insipidus treatment, 0.1 - 0.2 mL once or twice daily. Diabetes insipidus diagnosis, 0.2 mL as single dose. Limit fluid intake to maximum 0.5 litres from 1 hour before to 8 hours after administration.

  Renal function testing, 0.4 mL. DDAVP Tablets: Diabetes insipidus, initially 0.1 mg three times daily. Maintenance 0.1 - 0.2 mg three times daily. Post-hypophysectomy polyuria/ polydipsia, titrate dose according to urine osmolality.

  DDAVP/Desmopressin Injection: 1 - 4 micrograms intramuscularly, subcutaneously or intravenously

• Child Dosage
  DDAVP/Desmopressin Intranasal Solution: Diabetes insipidus treatment, 0.05 - 0.2 mL daily, infants may require a lower dose. Diabetes insipidus diagnosis, 0.2 mL as single dose. Limit fluid intake to maximum 0.5 litres from 1 hour before to 8 hours after administration. Renal function testing, up to 1 year, 0.1 mL; 1 - 15 years, 0.2 mL. DDAVP Tablets: Diabetes insipidus, initially 0.1 mg three times daily. Maintenance 0.1 - 0.2 mg three times daily. Post-hypophysectomy polyuria/ polydipsia, titrate dose according to urine osmolality. DDAVP/Desmopressin Injection: Doses from 0.4 micrograms (0.1mL) may be used.
• Contra Indications
  Cardiac insufficiency, hypertension.
• Special Precautions
  

  Exclude psychogenic polydipsia and alcohol abuse before initiating therapy. Renal impairment, cardiovascular disease, electrolyte imbalance, cystic fibrosis. Pregnancy. Avoid fluid overload.

• Interactions
  Indometacin (indomethacin), tricyclic antidepressants, chlorpromazine, carbamazepine.
• Adverse Drug Reactions
  Headache, stomach pain, nausea. Hyponatraemic convulsions.