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Drug Details

DAONIL

• Drug Class Description
  Sulphonylureas.
• Generic Name
  Glibenclamide
• Presentation
  Daonil: Glibenclamide 5 mg . Semi-Daonil: Glibenclamide 2.5 mg .
• Description
  Daonil: white oblong scored tablet marked LDI with symbol. Semi-Daonil: white scored tablet marked LBG with symbol.
• Indications
  

  Non-insulin dependent (type 2) diabetes.

• Adult Dosage
  

  Initially 5 mg daily as single dose at breakfast increasing if necessary by 2 .5 - 5 mg at weekly intervals to maximum 15 mg daily.

• Child Dosage
  Not applicable.
• Contra Indications
  

  Juvenile, growth-onset or unstable brittle diabetes, ketoacidosis, severe renal and liver insufficiency, endocrine disorders, stress, infections, surgical procedures. Pregnancy, lactation.

• Special Precautions
  Elderly, renal failure.
• Interactions
  b-blockers, MAOIs, corticosteroids, corticotropin (corticotrophin), diuretics, oral contraceptives, alcohol. Bezafibrate, clofibrate, oral anticoagulants, aspirin, phenylbutazone, cyclophosphamide, rifampicin, sulphonamides, chloramphenicol, glucagon.
• Adverse Drug Reactions
  Sensitivity reactions including skin rash.