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Drug Details

KABIKINASE

• Drug Class Description
  Fibrinolytics.
• Generic Name
  Streptokinase
• Presentation
  Infusion, streptokinase 250,000 units ; 750,000 units ; 1.5 million units .
• Description
  Powder in vials.
• Indications
  

  Deep vein thrombosis, pulmonary embolism, acute arterial thromboembolism, acute myocardial infarction, clotted haemodialysis shunts.

• Adult Dosage
  

  Intravascular administration: initially 600,000 i.u. over 30 - 60 minutes, maintenance, 100, 000 i.u. hourly for 3 - 6 days. Acute M.I., 1 .5 million i.u. by intravenous infusion over 1 hour. Haemodialysis shunts.

• Child Dosage
  Titrate initially; maintenance, 1300 - 1400 i.u./kg body-weight/ hour for 3 - 6 days. See data sheet. Not recommended in acute M.I.
• Contra Indications
  

  Allergy to streptokinase, recent streptokinase therapy (5 days to 6 months previously), severe liver or kidney damage. Recent haemorrhage or CVA, fibrinolysis and uncontrolled bleeding disorders, haemorrhagic diathesis, severe hypertension, streptococcal infections, subacute bacterial endocarditis. Recent surgery, bleeding tendencies. Pregnancy.

• Special Precautions
  Obtain haemostatic status of patient before starting therapy. Follow up with anticoagulant therapy; see data sheet. Haemorrhagic retinopathy.
• Interactions
  Anticoagulants, drugs affecting platelet function.
• Adverse Drug Reactions
  Hypotension, arrhythmias. Febrile reactions, anaphylaxis (rare), polyneuropathy, uveitis. Haemorrhage.