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Drug Details

ANGETTES 75

• Drug Class Description
  Antiplatelets (antiplatelet agents, salicylates).
• Generic Name
  Aspirin
• Presentation
  Tablets
• Description
  Each tablet contains: Aspirin BP 75 mg
• Indications
  For the secondary prevention of thrombotic cerebrovascular or cardiovascular disease and following by-pass surgery. The advice of a doctor should be sought before commencing therapy for the first time.
• Adult Dosage
  

  The usual dosage, for long-term use, is 75mg - 150mg once daily. In some circumstances a higher dose may be appropriate, especially in short-term, and up to 300mg a day may be used on the advice of a doctor.

• Child Dosage
  

  Do not give to children aged under 16 years, unless specifically indicated (e.g. for Kawasaki's disease).

• Elderly Dosage
  

  The risk/benefit ratios in the elderly have not been fully established

• Contra Indications
  

  Active or history of peptic ulceration, haemophilia and other bleeding disorders, hypersensitivity to aspirin.

• Special Precautions
  

  Aspirin may induce gastro-intestinal haemorrhage, occasionally major. Patients with hypertension should be carefully monitored.

  There is a possible association between aspirin and Reye's syndrome when given to children. Reye's syndrome is a very rare disease, which affects the brain and liver, and can be fatal. For this reason aspirin should not be given to children aged under 16 years unless specifically indicated (e.g. for Kawasaki's disease).

• Interactions
  

  Aspirin may enhance the effects of anticoagulants and may inhibit the action of uricosurics.

  Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are dosed concomitantly. However, the limitations of these data and the uncertainties regarding extrapolation of ex-vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no clinically relevant effect is considered to be likely for occasional ibuprofen use

• Adverse Drug Reactions
  

  Aspirin may enhance the effects of anticoagulants and may inhibit the action of uricosurics. Aspirin may precipitate bronchospasm and may induce attacks of asthma in susceptible subjects. Hypersensitivity reactions have been reported in susceptible individuals.