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Drug Details

Papaveretum

• Drug Class Description
  Narcotic analgesics (opiates / opioids).
• Generic Name
  Generic
• Presentation
  Injection, papaveretum 7.7mg/mL , 15.4mg/mL .
• Description
  Solution for injection in ampoules.
• Indications
  Pre- operative medication. Enhancement of anaesthetics during operations. Relief of postoperative pain. Relief of severe chronic pain.
• Adult Dosage
  

  7.7 - 15.4mg as a single dose. The dose is not usually repeated more often than 4 hourly. For pre-operative medication the route is subcutaneous or intramuscular. For all other indications the intravenous route may also be used.

• Child Dosage
  Under 1 month, 115 micrograms per kg body weight; 1 month to 1 year, 154 micrograms per kg body weight; 1 to 5 years, 1.93 - 3.85  weight; 1 to 5 years, 1.93 - 3.85 mg maximum single dose; 6 to 12 years, 3.85mg to 7.7 mg maximum single dose.
• Elderly Dosage
  The initial dose should not exceed 7.7mg.
• Contra Indications
  Coma, respiratory depression or obstructive airways disease. Hypersensitivity to opium alkaloids. Within two weeks of administration of MAOIs.
• Special Precautions
  

  Administration during labour. Hypothyroidism, head injury, renal and chronic hepatic disease, raised intracranial pressure, biliary tract disease, prostatic hypertrophy, adrenocortical insufficiency.

  Elderly. Patients exhibiting acute alcoholism, raised intracranial pressure or convulsive disorders. Respiratory insufficiency. Pregnancy, lactation.

• Interactions
  MAOIs, CNS depressants, phenothiazines, alcohol.
• Adverse Drug Reactions
  

  Respiratory depression, dizziness, nausea, vomiting, urinary retention and constipation. Tolerance and dependence may occur with repeated administration.