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Drug Details

IMDUR

• Drug Class Description
  Nitrates.
• Generic Name
  Isosorbide mononitrate
• Presentation
  Extended release film coated tablet (Durules®)
• Description
  Isosorbide mononitrate 60mg
• Indications
  Prophylactic treatment of angina pectoris.
• Adult Dosage
  

  Dosage

  Adults:

  Imdur 60mg (one tablet) once daily given in the morning. The dose may be increased to 120mg (two tablets) daily, both to be taken once daily in the morning. The dose can be titrated to minimise the possibility of headache, by initiating treatment with 30mg (half a tablet) for the first 2-4 days.

  Administration:

  Imdur Tablets must not be chewed or crushed. They should be swallowed whole with half a glass of water.

• Child Dosage
  

  The safety and efficacy of Imdur in children has not been established.

• Contra Indications
  

  Hypersensitivity to any of the components. Constrictive cardiomyopathy and pericarditis, aortic stenosis, cardiac tamponade, mitral stenosis and severe anaemia.

  Patients treated with Imdur must not be given Phosphodiesterase Type 5 Inhibitors (e.g. sildenafil).

  Severe cerebrovascular insufficiency or hypotension are relative contraindications to the use of Imdur.

• Special Precautions
  

  Imdur is not indicated for relief of acute angina attacks; in the event of an acute attack, sublingual or buccal glyceryl trinitrate tablets should be used.

• Interactions
  

  Concomitant administration of Imdur and Phosphodiesterase Type 5 Inhibitors can potentiate the vasodilatory effect of Imdur with the potential result of serious side effects such as syncope or myocardial infarction. Therefore, Imdur and Phosphodiesterase Type 5 Inhibitors (e.g. sildenafil) must not be given concomitantly.

• Adverse Drug Reactions
  

  Most of the adverse reactions are pharmacodynamically mediated and dose dependent. Headache may occur when treatment is initiated, but usually disappears after 1-2 weeks of treatment. The dose can be titrated to minimise the possibility of headache, by initiating treatment with 30mg. Hypotension, with symptoms such as dizziness and nausea, has occasionally been reported. These symptoms generally disappear during continued treatment. Rash and pruritus have been reported rarely. Myalgia has been reported very rarely.