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Drug Details

HELICLEAR

• Drug Class Description
  Proton pump inhibitors (PPIs) / macrolides / broad spectrum penicillins (antibiotics).
• Generic Name
  Lansoprazole, clarithromycin, amoxicillin [amoxycillin]
• Presentation
  Treatment pack containing 14 Zoton (lansoprazole) capsules, 14 Klaricid (clarithromycin) 500mg tablets, 28 amoxicillin 500mg capsules.
• Description
  Zoton Capsules: lilac/purple capsules marked with strength and company name. Klaricid Tablets: yellow oval f-c tablets with logo. Amoxycillin Capsules: capsules.
• Indications
  Eradication of Helicobacter pylori in patients with duodenal ulcers
• Adult Dosage
  1 x Zoton capsule, 1 x Klaricid tablet and 2 x amoxycillin capsules all twice daily for seven days.
• Child Dosage
  Not recommended
• Contra Indications
  Severe renal impairment. Pregnacy
• Special Precautions
  Exclude malignacy pror to treatment. Renal or hepatic  treatment. Renal or hepatic impairment. Lactation
• Interactions
  

  Drugs metabolised by cytochrome P450 system (eg, warfarin, ergot alkaloids, triazolam, midazolam, disopyramide, lovastatin, rifabutin, phenytoin and cyclosporin). Rhabdomyolysis, coincident with the co- administration of clarithromycin, and HMG-CoA reductase inhibitors, such as lovastatin and simvastatin has been reported.

  Theophylline, oral anticoagulants, digoxin, carbamazepine, ritonavir, zidovudine, statins, phenytoin, antacids, sulcrafate, oral contraceptives.

• Adverse Drug Reactions
  

  Amoxycillin : GI upset, hypersensitivity reactions. Clarithromycin : GI upset, paraesthesia, stomatitis, glossitis, oral monilia, tongue and tooth discolouration, headache, arthralgia, myalgia, and allergic reactions ranging from urticaria and mild skin eruptions and angioedema to anapyhlaxis and rarely Stevens- Johnson syndrome.

  Hepatic dysfunction, reversible hearing loss. Rarely, pseudomembranous colitis, hypoglycaemia, leucopenia, thrombocytopenia, renal dysfunction, interstitial nephritis, and renal failure. QT prolongation, ventricular tachycardia and Torsades de Pointes have been reported rarely.

  Lansoprazole: Headache, dizziness, fatigue, malaise, GI upset, sore throat, skin irritation, hypersensitivity reactions, raised liver function values, jaundice, hepatitis, increased risk of GI infections. Rarely arthralgia, myalgia, peripheral oedema, haematological changes, erythmatous or bullous rashes, photosensitivity, interstitial nephritis, confusion, hallucinations, gynaecomastia, impotence.