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Drug Details

XATRAL (BPH)

• Drug Class Description
  Uroselective a1 -blocker (alpha- blockers / alpha-adrenoceptor blocking drugs).
• Generic Name
  Alfuzosin hydrochloride
• Presentation
  Tablets, alfuzosin hydrochloride 2.5 mg .
• Description
  White film-coated tablets marked XATRAL 2.5.
• Indications
  

  Benign prostatic hypertrophy. (BPH)

• Adult Dosage
  

  Xatral tablets should be swallowed whole. The first dose should be given just before bedtime.

   

  Adults

  The usual dose is one tablet three times daily. The dose may be increased to a maximum of 4 tablets (10mg) per day depending on the clinical response.

   

  Elderly and treated hypertensive patients

  As a routine precaution when prescribing alfuzosin to elderly patients (aged over 65 years) and the treated hypertensive patient, the initial dose should be 1 tablet in the morning and 1 tablet in the evening.

   

  Renal insufficiency

  In patients with renal insufficiency, as a precaution, it is recommended that the dosing be started at Xatral 2.5mg twice daily adjusted according to clinical response.

   

  Hepatic insufficiency

  In patients with mild to moderate hepatic insufficiency, it is recommended that therapy should commence with a single dose of Xatral 2.5mg/day to be increased to Xatral 2.5mg twice daily according to clinical response.

   

  Paediatric population

  Efficacy of alfuzosin has not been demonstrated in children aged 2 to 16 years. Therefore, alfuzosin is not indicated for use in the paediatric population.

• Child Dosage
  

  Efficacy of alfuzosin has not been demonstrated in children aged 2 to 16 years. Therefore, alfuzosin is not indicated for use in the paediatric population.

• Elderly Dosage
  

  As a routine precaution when prescribing alfuzosin to elderly patients (aged over 65 years) and the treated hypertensive patient, the initial dose should be 1 tablet in the morning and 1 tablet in the evening.

• Contra Indications
  Hypersensitivity to alfuzosin. History of orthostatic hypotension. Co-administration with other alpha-blockers. Severe hepatic insufficiency.
• Special Precautions
  

  Renal or hepatic impairment. Hypertension; monitor BP regularly, particularly at start of treatment. Coronary insufficiency; discontinue if angina deteriorates. Withdraw 24 hours before anaesthesia.

• Interactions
  Other a-blockers, antihypertensives.  antihypertensives.
• Adverse Drug Reactions
  

  Faintness, vertigo, dizziness or malaise, headache, GI upset. Orthostatic hypotension, syncope, tachycardia, palpitations, chest pain, fatigue, drowsiness, rash, pruritus, flushes, oedema.