Search The Medical Knowledge Base

Drug Details

SangCyA

• Drug Class Description
  Immunosuppressants.
• Generic Name
  Cyclosporin - nephrotic syndrome Imtix Sangstat has withdrawn SangCyA from the UK market. It remains available on a named patient basis for patients who were receiving the product before it was withdrawn in July 2000.
• Presentation
  Oral solution, cyclosporin Ph Eur 100mg per mL.
• Description
  Solution for oral administration.
• Indications
  Treatment of steroid dependent or steroid resistant nephrotic syndrome (associated with adverse prognostic features) due to minimal change glomerulonephritis, focal segmental glomerulosclerosis or membranous glomerulonephritis in both adults and children.
• Adult Dosage
  

  To induce remission, 5mg/kg per day given orally in two divided doses, if, with the exception of proteinuria, the renal function is normal. In impaired renal function, 2.5mg/kg per day. Maintenance treatment, maximum recommended dose is 5mg/kg per day orally.

• Child Dosage
  To induce remission, 6mg/kg per  To induce remission, 6mg/kg per day given orally in two divided doses, if, with the exception of proteinuria, the renal function is normal. In impaired renal function, 2.5mg/kg per day. Maintenance treatment, maximum recommended dose is 6mg/kg per day orally.
• Contra Indications
  

  Known hypersensitivity to cyclosporin or to one of the excipients. Uncontrolled hypertension, uncontrolled infections or any kind of malignancy. Lactation.

• Special Precautions
  

  May impair renal function; monitor serum creatinine and urea. May affect liver function; monitor bilirubin and hepatic enzymes. Monitor serum potassium. Hyperuricaemia. Monitor blood pressure regularly. Monitor blood lipid levels. See Summary of Product Characteristics. Pregnancy.

• Interactions
  

  Systemic antibiotics or other compounds known to have nephrotoxic effects, eg, amphotericin B, aminoglycosides, ciprofloxacin, melphalan, trimethoprim. Ketoconazole, erythromycin, oral contraceptives, danazol, some calcium channel blockers including diltiazem, nicardipine and verapamil.

  Doxycycline, fluconazole, itraconazole, propafenone, lipid solutions. Phenytoin, carbamazepine, barbiturates, rifampicin. Sulphadiazine. Intravenous sulphadimidine. Prednisolone, methylprednisolone. NSAIDs. Lovastatin. Colchicine. Nifedipine. Potassium supplements, potassium-sparing diuretics. Grapefruit juice. Live attenuated vaccines.

• Adverse Drug Reactions
  

  Reversible and dose-dependent increase in serum creatinine and urea. Renal structural changes. Hypertrichosis, tremor, hyperrension, hepatic dysfunction, fatigue, gingival hypertrophy, gastrointestinal disturbances, and burning Occasionally, headaches, rash, mild anaemia, hyperkalaemia, hyperuricaemia, gout, hypomagnesaemia, hypercholesterolaemia, weight increase, oedema, pancreatitis, neuropathy, confusion, paraesthesia, convulsions, reversible dysmenorrhoea or amenorrhoea may develop. Muscle weakness, muscle cramps and myopathy. Rarely, a syndrome of thrombocytopenia, sometimes in combination with microangiopathic haemolytic anaemia and renal failure has been observed. Rarely, gynaecomastia.