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Drug Details

Ketoprofen

• Drug Class Description
  Non-steroidal anti-inflammatory drugs (NSAIDs).
• Generic Name
  Generic
• Presentation
  Capsules, ketoprofen 50mg , 100mg . Available from APS (Ketovail R - 100mg sustained release), Generics UK, Goldshield (KetpronR XL - 100mg sustained release), Hillcross, Lagap. Capsules, ketoprofen 200mg . Available from APS (Ketovail R ), Ashbourne (Ketozip R XL 200), Cox (Jomethid R XL), Galen (KetotardR XL), Goldshield (KetpronR ), Hillcross, Lagap (LarafenR CR), Opus (FenoketR ).
• Description
  Capsules/sustained release capsules.
• Indications
  

  Rheumatoid arthritis, osteoarthrosis, ankylosing spondylitis, acute articular and peri-articular disorders, cervical spondylitis, low back pain, painful musculoskeletal conditions, dysmenorrhoea, acute gout, post-operative pain following orthopaedic surgery.

• Adult Dosage
  

  Rheumatic disease, 100 - 200mg in two to four divided doses with food.

  Pain and dysmenorrhoea, 50mg three times daily with food. Sustained release preparations, 100 - 200mg once daily with food.

• Child Dosage
  Not recommended.
• Contra Indications
  

  Aspirin/anti-inflammatory induced allergy, asthma. Severe renal dysfunction.

  Active peptic ulcer or history of recurrent dyspepsia or peptic ulceration. Pregnancy and lactation. Coagulation defects.

• Special Precautions
  

  Renal impairment, monitor on long term therapy, heart failure, elderly. Bronchial asthma or allergic disease.

• Interactions
  Anticoagulants, sulphonamides, hydantoins, aspirin, other NSAIDs, high dose methotrexate.
• Adverse Drug Reactions
  

  Gastrointestinal effects including indigestion, dyspepsia, nausea, constipation, diarrhoea, heartburn, thrombocytopenia and abdominal discomfort. Less commonly, headache, dizziness, mild confusion, vertigo, drowsiness, oedema, mood change, insomnia. Rarely, peptic ulceration, haemorrhage or perforation.