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Drug Details

ASPAV

• Drug Class Description
  Salicylates / opiates (opioids / compound analgesics).
• Generic Name
  Aspirin, papaveretum
• Presentation
  Tablets, aspirin 500mg, papaveretum 7.71mg (equivalent to morphine anhydrate 5mg).
• Description
  White dispersible tablets.
• Indications
  Relief of moderate to severe pain in post-operative states and chronic pain associated with inoperable carcinoma.  inoperable carcinoma.
• Adult Dosage
  1 or 2 dispersed in water every 4 to 6 hours; maximum 8 in 24 hours.
• Child Dosage
  Not recommended.
• Contra Indications
  

  Comatose states. Respiratory depression, obstructive airways disease, nasal polyps, aspirin/ anti-inflammatory induced allergy, history of peptic ulceration or dyspepsia, haemorrhagic disorders, diarrhoea associated with pseudomembranous colitis.

• Special Precautions
  

  Allergic disease, anaemia, asthma, heart failure, dehydration, glucose-6-phosphate dehydrogenase deficiency, gout, renal or hepatic impairment, surgery, SLE, thyrotoxicosis, hypothyroidism, inflammatory bowel disease, head injury, gall bladder disease, prostatic hypertrophy, adrenocortical insufficiency, hypotension, shock, myasthenia gravis, phaeochromocytoma, GI lesions. Pregnancy (avoid in last trimester unless under medical supervision), labour, lactation.

• Interactions
  

  MAOIs, CNS depressants, anticoagulants, corticosteroids, diuretics, hypoglycaemics, NSAIDs, uricosurics, methotrexate, mifepristone, vancomycin, urine tests, antibiotics, cyclizine, mexiletine, metoclopramide, domperidone, cimetidine, anticholinergics, loperamide, kaolin, antihypertensives, neuromuscular blocking agents.

• Adverse Drug Reactions
  

  Allergic reactions, GI bleeding, GI upset, anaemia, CNS effects, bradycardia, palpitations, hypotension, confusion, blurred vision, tinnitus, genito-urinary effects, withdrawal reactions.