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Drug Details

SECADREX

• Drug Class Description
  Cardioselective b-blockers (beta- blockers) / thiazide diuretics.
• Generic Name
  Acebutolol, Hydrochlorothiazide
• Presentation
  Tablets, acebutolol (as hydrochloride) 200 mg, hydrochlorothiazide 12.5 mg.
• Description
  White f-c tablets marked SECADREX.
• Indications
  

  Mild to moderate hypertension.

• Adult Dosage
  1 - 2 once daily.
• Child Dosage
  Not recommended.
• Contra Indications
  

  2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, severe peripheral arterial disease, uncompensated cardiac failure, cardiogenic shock, hypotension, right ventricular failure secondary to pulmonary hypertension, significant cardiomegaly, untreated phaechromocytoma. Anuria, severe or progressive renal failure.

• Special Precautions
  

  Poor cardiac reserve should be controlled with digitalis and diuretics. History of bronchospasm (cardio-selective b- blockers usually have a lesser effect on airways resistance than the non-selective type but their use should also be avoided in patients with wheezing or obstructive airways disease unless there are compelling clinical reasons). Diabetes; metabolic acidosis.

  Asthenic symptoms. Cerebrovascular insufficiency. Renal or hepatic impairment, thyrotoxic crisis. General anaesthesia; consider withdrawal before elective surgery. Pregnancy, lactation. Withdraw gradually. Gout, diabetes, hyperlipidaemia. Monitor electrolyte levels; thiazide diuretics can cause hypokalaemia so K+-supplements may be required.

• Interactions
  

  Clonidine withdrawal, verapamil, diltiazem, class II antiarrhythmics, cardiac depressant anaesthetics, hypoglycaemics, reserpine, other antihypertensives, ergot alkaloids, cimetidine, rifampicin, theophylline, warfarin, CNS depressants, sympathomimetics, indometacin (indomethacin). Lithium, NSAIDs, digitalis, allopurinol, amantadine.

• Adverse Drug Reactions
  

  Cold extremities, sleep disturbances (particularly with the more lipophilic drugs), bradycardia, exertional tiredness, bronchospasm, heart If unexplained dry eyes or skin rash occur withdraw gradually. Gout, photosensitivity, rash, blood dyscrasias, weakness.