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Drug Details

KALTEN

• Drug Class Description
  Cardioselective b-blockers (beta- blockers) / thiazide diuretics (thiazides) / K+-sparing diuretics (potassium-sparing diuretics).
• Generic Name
  Atenolol, hydrochlorothiazide, amiloride
• Presentation
  Capsules, atenolol 50mg, hydrochlorothiazide 25mg, amiloride hydrochloride 2.5mg.
• Description
  Red and cream capsules marked with KALTEN and logo.
• Indications
  

  Hypertension.

• Adult Dosage
  1 daily.
• Child Dosage
  Not recommended.
• Contra Indications
  

  2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, severe peripheral arterial disease, uncompensated cardiac failure, cardiogenic shock, hypotension, untreated phaechromocytoma. Anuria, severe or progressive renal failure.

  Known hypersensitivity to components. Metabolic acidosis. Hyperkalaemia (serum K+ greater than 5.5mmol/L). Diabetic nephropathy. Prinzmetal's angina.

• Special Precautions
  

  Poor cardiac reserve should be controlled with digitalis and diuretics. History of bronchospasm (cardio-selective b- blockers usually have a lesser effect on airways resistance than the non-selective type but their use should also be avoided in patients with wheezing or obstructive airways disease unless there are compelling clinical reasons).

  Diabetes; metabolic acidosis. Asthenic symptoms. Cerebrovascular insufficiency. Renal or hepatic impairment, thyrotoxic crisis. General anaesthesia; consider withdrawal before elective surgery. Pregnancy, lactation. Withdraw gradually. Gout, diabetes, hyperlipidaemia. Monitor electrolyte levels; K+- sparing diuretics can cause hyperkalaemia in which case K+- supplements are contraindicated.

• Interactions
  

  Clonidine withdrawal, verapamil, diltiazem, class I antiarrhythmics, class II calcium antagonists, cardiac depressant anaesthetics, hypoglycaemics, reserpine, other antihypertensives, ergot alkaloids, cimetidine, rifampicin, theophylline, warfarin, CNS depressants, sympathomimetics, indometacin (indomethacin). Lithium, NSAIDs, digitalis, allopurinol,

• Adverse Drug Reactions
  

  Cold extremities, sleep disturbances (particularly with the more lipophilic drugs), bradycardia, exertional tiredness, bronchospasm, heart failure, hypotension, GI upset.

  If unexplained dry eyes or skin rash occur withdraw gradually. Gout, photosensitivity, rash, blood dyscrasias, weakness.