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Drug Details

ACEPRIL

• Drug Class Description
  ACE inhibitors.
• Generic Name
  Captopril - hypertension/diabetes
• Presentation
  Tablets, captopril 12.5mg , 25mg , 50mg .
• Description
  12.5 mg, white scored capsule- shaped tablet marked ACE and 12.5; 25 mg, 50 mg white scored tablets marked ACE and tablet strength.
• Indications
  

  Mild to moderate hypertension. Severe hypertension where standard therapy is ineffective or inappropriate. Diabetic nephropathy in insulin dependent diabetes.

• Adult Dosage
  

  Mild to moderate hypertension
   Initially 12 .5 mg twice daily. Maintenance, 25 mg twice daily increasing gradually at 2 - 4 week intervals if necessary to maximum 50 mg twice daily.

  Severe hypertension
  Initially 12.5 mg twice daily increasing if necessary to maximum 50 mg three times daily. Diabetic nephropathy, 75 - 100 mg daily in divided doses.

• Child Dosage
  Contact manufacturer.
• Contra Indications
  
  • Obstruction
  • Pregnancy
  • lactation.
• Special Precautions
  

  Renovascular hypertension
  severe congestive heart failure. Haemodialysis.

  Renal impairment
  monitor renal function, white cell count and urinary protein before and during therapy.

  Collagen vascular disease
  Anaesthesia. Elderly.

• Interactions
  
  • K+-sparing diuretics or K+ supplements
  •  NSAIDs
  •  vasodilators
  •  clonidine
  •  allopurinol
  •  procainamide
  •  probenecid
  •  immunosuppressants
  •  lithium
  •  antidiabetic agents
  • neuroleptics
  •  tricyclic antidepressants
  • antihypertensives.
• Adverse Drug Reactions
  
  • Neutropenia
  • Agranulocytosis
  • Thrombocytopenia
  • Anaemia
  • Proteinuria
  • Hypotension
  • Angioedema
  • Rash
  • Loss of taste
  • Pancreatitis
  • Tachycardia
  • Gastric irritation
  • Cough (rare).