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Drug Details

TANATRIL

• Drug Class Description
  ACE inhibitors.
• Generic Name
  Imidapril hydrochloride
• Presentation
  Tablets, imidapril tablets 5mg , 10mg , 20mg .
• Description
  White oblong scored tablets.
• Indications
  

  Treatment of essential hypertension.

• Adult Dosage
  

  Initially 5mg once daily at the same time each day 15 minutes same time each day 15 minutes before a meal.

  If necessary, increase after 3 weeks to 10mg once daily; maximum, 20mg once daily. Correct any salt and volume depletion, and discontinue any diuretic 2-3 days before initiating therapy.

• Child Dosage
  Not recommended.
• Elderly Dosage
  Initially 2.5mg once daily at the same time each day 15 minutes before a meal. Titrate dose according to response; maximum 10mg once daily.
• Contra Indications
  

  Hypersensitivity to imidapril or any other ACE inhibitor. History of angioneurotic oedema associated with previous ACE inhibitor therapy, hereditary or idiopathic angioedema, renovascular hypertension, renal failure with or without haemodialysis (creatinine clearance <10mL/minute). Pregnancy, lactation.

• Special Precautions
  

  Risk of severe hypotension in volume depletion, hyponatraemia or cardiac failure. Renal impairment; monitor renal function before and during therapy.

  Hepatic impairment, aortic stenosis, hypertrophic cardiomyopathy, psoriasis. Surgery. Haemodialysis or apheresis with high-flux membranes.

• Interactions
  

  K+ supplements, K+ sparing diuretics, lithium, anaesthetics, narcotics, antipsychotics, antihypertensive agents, allopurinol, cytostatics, immunosuppressants, systemic corticosteroids, NSAIDs, rifampicin, insulin, oral hypoglycaemics, antacids, sympathomimetics, procainamide. Desensitisation therapy to insect bites and stings.

• Adverse Drug Reactions
  

  Cough, dizziness, fatigue, GI upset, angioedema, severe hypotension, renal failure, hypersensitivity reactions.