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Drug Details

Debrisoquine

• Drug Class Description
  Adrenergic neurone blockers.
• Generic Name
  Generic
• Presentation
  Tablets, debrisoquine 10mg . Available from Cambridge Laboratories.
• Description
  Round white tablets with Roche 10 imprinted on one face and scored on the other.
• Indications
  

  All grades of hypertension, either alone or in combination with other antihypertensives or diuretics..

• Adult Dosage
  

  Mild to moderate hypertension: 10mg once or twice daily; increase by 10mg every three days. Usual dose range, 20 - 60mg daily. Severe

  Hypertension: 20mg once or twice daily, increased if necessary depending on response by 10 - 20mg every three or four days provided close check kept on blood pressure. Usual dose range, 40 - 120mg daily. Maximum daily dose, 300mg.

• Child Dosage
  Not recommended.
• Contra Indications
  Phaeochromocytoma, recent history of myocardial infarction,  of myocardial infarction, hypersensitivity to debrisoquine.
• Special Precautions
  Renal or hepatic insufficiency, coronary or cerebral insufficiency. Elderly. Withdraw slowly. Pregnancy.
• Adverse Drug Reactions
  

  Postural hypotension, malaise, nausea, headacche, sweating, oedema, muscle weakness, failure of ejaculation in males, disturbances of micturition and nocturia.