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Drug Details

LASORIDE

• Drug Class Description
  Loop diuretics / K+-sparing diuretics (potassium-sparing diuretics).
• Generic Name
  Frusemide [furosemide], amiloride [co-amilofruse]
• Presentation
  Tablets, frusemide (furosemide) 40mg, amiloride hydrochloride 5mg.
• Description
  Yellow tablets.
• Indications
  Prompt diuresis where potassium conservation is important.
• Adult Dosage
  

  1 - 2 in the morning.

• Child Dosage
  Not recommended.
• Elderly Dosage
  Adjust dose according to renal function, response and electrolyte levels.
• Contra Indications
  Severe or progressive renal failure. Precomatose states associated with liver cirrhosis. Hyperkalaemia, Addison's disease, electrolyte imbalance.
• Special Precautions
  Prostatic hypertrophy, impaired micturition, diabetes, gout. Elderly. Pregnancy, lactation. Monitor fluid and electrolyte levels regularly.
• Interactions
  

  K+ supplements and K+-sparing diuretics (avoid). Lithium, nephrotoxic or ototoxic antibiotics, NSAIDs, digitalis, antihypertensives, antidiabetic agents, non-depolarising muscle relaxants.

• Adverse Drug Reactions
  

  Malaise, GI disturbances, pruritus. Blood dyscrasias (withdraw). Reduced alertness, calcium depletion. Rarely minor psychiatric disturbances, altered liver function tests, ototoxicity, pancreatitis.