There are clearly established links between hypogonadism and depression, cardiovascular risk, diabetes and metabolic syndrome, osteoporosis, and other chronic illnesses. Low testosterone values are also associated with increased mortality, even after adjusting for age, comorbidities, and other clinical covariates Figure. See Figure 2
Figure 2. Reduced Survival in Men with Low Testosterone Levels
Testosterone replacement therapy can improve libido, mood, increase bone density, and improve body composition and quality of life in hypogonadal men. Treatment may also improve insulin resistance, reduce central obesity, and improve other risk factors for cardiovascular disease. Benefits of treatment.