Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control studyBackground: Most patients undergoing caesarean delivery with general anaesthesia require systemic opioid administration. Due to its rapid onset and long duration of action, intravenous methadone may make it suitable for analgesia after caesarean delivery. Intraoperative methadone combined with postoperative intravenous..
Insertion of an intrathecal catheter following accidental dural puncture: a meta-analysisBackground: Inserting an intrathecal catheter after accidental dural puncture in parturients to prevent postdural puncture headache is becoming increasingly popular. We aimed to identify relevant published articles investigating this intervention and subject data to a meta-analysis. Methods: A systematic literature..
The impact of spinal anaesthesia for caesarean delivery on coagulation assessed by thromboelastography
The impact of spinal anaesthesia for caesarean delivery on coagulation assessed by thromboelastographyBackground: Pregnancy and puerperium are associated with a hypercoagulable state. The aim of the study was to assess the impact of spinal anaesthesia on coagulation using thromboelastography in healthy term pregnant women undergoing elective caesarean delivery. Methods: Thromboelastography was performed on 60 women..
A dose–response study of remifentanil for attenuation of the hypertensive response to laryngoscopy and tracheal intubation in severely preeclamptic women undergoing caesarean delivery under general anaesthesia
A dose–response study of remifentanil for attenuation of the hypertensive response to laryngoscopy and tracheal intubation in severely preeclamptic women undergoing caesarean delivery under general anaesthesiaBackground: Remifentanil is known to attenuate the cardiovascular responses to tracheal intubation. We determined effective doses (ED50/ED95) of remifentanil to prevent the pressor response to tracheal intubation in patients with severe preeclampsia. Methods: Seventy-five women with severe preeclampsia were randomly..
Magnesium and the obstetric anaesthetistMagnesium is one of the most abundant cations in the human body. It is utilised extensively within the medical world and its role in the treatment of various conditions in both mother and fetus is increasing. This review focuses on the importance of magnesium for the obstetric anaesthetist and looks at the most recent..
A population analysis of prescriptions for asthma medications during pregnancyBackground: It is important to control asthma during pregnancy. However, some studies indicate that women stop or change their asthma medications when they become pregnant. Objective: We used a population database to analyze changes in prescriptions for asthma medications to patients before, during, and after..
Warts and all: Human papillomavirus in primary immunodeficienciesInfection with human papillomavirus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in EVER1, EVER2, GATA2, CXCR4, and dedicator of cytokinesis..
Gene expression patterns of the 11β-hydroxysteroid dehydrogenase 2 enzyme in human placenta from intrauterine growth restriction: the role of impaired feto-maternal glucocorticoid metabolism
Gene expression patterns of the 11β-hydroxysteroid dehydrogenase 2 enzyme in human placenta from intrauterine growth restriction: the role of impaired feto-maternal glucocorticoid metabolismObjective: To assess 11-β-hydroxysteroid dehydrogenase 2 (11β-HSD2) gene expression patterns in human placental samples from intrauterine growth restriction (IUGR) pregnancies using normal pregnancy as control. Study design: We compared 11-β-HSD2 gene expression in placental samples from all IUGR pregnancies treated in..
Relationship of serum adipocyte-derived proteins with insulin sensitivity and reproductive features in pre-pubertal and pubertal daughters of polycystic ovary syndrome women
Relationship of serum adipocyte-derived proteins with insulin sensitivity and reproductive features in pre-pubertal and pubertal daughters of polycystic ovary syndrome womenObjective: To evaluate in a cross-sectional study adiponectin and leptin levels in prepubertal and pubertal daughters of women with PCOS and their relationship to insulin sensitivity and reproductive features. Study design: We studied 92 daughters of PCOS women (PCOSd) and 76 daughters of control women (Cd) matched by..
Comparison of laparoscopy and laparotomy for endometrial cancerObjective: To compare the safety and efficacy of laparoscopy and laparotomy on clinical outcomes among patients with endometrial cancer. Methods: Eligible randomized controlled trials (RCTs) conducted between 1966 and June 2010 were analyzed by meta-analysis. Results: Eight RCTs were included, with 3599 patients in..
Sublingual misoprostol versus intramuscular oxytocin for prevention of postpartum hemorrhage in low-risk women
Sublingual misoprostol versus intramuscular oxytocin for prevention of postpartum hemorrhage in low-risk womenObjective: To compare sublingual misoprostol with intramuscular oxytocin for prevention of postpartum hemorrhage (PPH) in low-risk vaginal birth. Methods: In a prospective, randomized, double-blind trial, 530 women without risk of PPH were randomly allocated to receive either 400μg of misoprostol sublingually or 10..
Toluidine blue staining in the diagnosis of endometrial pathologies: a preliminary study before chromohysteroscopy
Toluidine blue staining in the diagnosis of endometrial pathologies: a preliminary study before chromohysteroscopyObjective: To assess the efficacy of toluidine blue (TBlue) staining in the detection of endometrial premalignant or malignant lesions in uterine specimens obtained from hysterectomies. We hoped that the results of this preliminary study would help us in our future studies which may be on chromohysteroscopy. Study..
Maternal serum protein S forms in pregnancies complicated by intrauterine growth restrictionObjectives: The clinical relevance of protein S deficiency in pregnant women remains controversial. Major debate exists regarding which parameter (total protein S antigen, free protein S antigen or functional protein S) should be evaluated in order to define protein S deficiency. The present study aimed to identify..
Narrow band imaging hysteroscopy: A comparative study using randomized video imagesNarrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at..
International Journal of Cancer
Frequency of mismatch repair deficiency in ovarian cancer: a systematic reviewLoss of mismatch repair (MMR) capacity may represent an important tumor initiating mechanism in ovarian cancer. We conducted a systematic review to analyze the frequency of microsatellite instability (MSI), immunohistochemical (IHC) staining for MMR proteins, and hypermethylation of the MLH1 promoter region in ovarian..
Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: Clinical and prognostic implications
International Journal of Cancer
Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: Clinical and prognostic implicationsTo understand the importance of frequent deletion of chromosomal 11q23.3-24.3 region in cervical carcinogenesis, alterations (deletion/methylation/mutation/expression) of the candidate genes LOH11CR2A, EI24 and CHEK1 located in the region were analyzed in 29 cervical intraepithelial neoplasia (CIN), 112 cervical..