Rheumatology Medical Journal Abstracts
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Which Patients Are Most Likely to Benefit From Total Joint Arthroplasty?
Arthritis & Rheumatism
Apr 2013
Which Patients Are Most Likely to Benefit From Total Joint Arthroplasty?
Objective: To evaluate patient predictors of good outcome following total joint arthroplasty (TJA). Methods: A population cohort with hip/knee arthritis (osteoarthritis [OA] or inflammatory arthritis) ages ≥55 years was recruited between 1996 and 1998 (baseline) and assessed annually for demographics, troublesome..Variants in RUNX3 Contribute to Susceptibility to Psoriatic Arthritis, Exhibiting Further Common Ground With Ankylosing Spondylitis
Arthritis & Rheumatism
Apr 2013
Variants in RUNX3 Contribute to Susceptibility to Psoriatic Arthritis, Exhibiting Further Common Ground With Ankylosing Spondylitis
Objective: Psoriatic arthritis (PsA) is a common inflammatory joint disease distinct from other chronic arthritides and frequently accompanied by psoriasis vulgaris. In a first genome-wide association study (GWAS), we were able to identify several genetic risk factors. However, even combined with previously identified..Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
Osteoarthritis and Cartilage
Apr 2013
Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI
Objective: To determine the effect of physical activity on knee osteoarthritis (OA) development in persons without knee injury and according to knee alignment. Design: We combined data from Multicenter Osteoarthritis (MOST) and Osteoarthritis Initiative (OAI), studies of persons with or at high risk of OA. Subjects..Clinical and radiological evaluation of sacroiliac joints compared with ultrasound examination in early spondyloarthritis
Rheumatology
Mar 2013
Clinical and radiological evaluation of sacroiliac joints compared with ultrasound examination in early spondyloarthritis
Objective. To compare clinical and X-ray examinations with US findings of SI joints (SIJ) in early SpA patients. Methods. Twenty-three early SpA patients, diagnosed according to Assessment of SpondyloArthritis international Society criteria, were investigated clinically [sacral sulcus tenderness, BASMI, BASFI, BASDAI,..Osteonecrosis of the Jaw and Nonmalignant Disease: Is There an Association with Rheumatoid Arthritis?
The Journal of Rheumatology
Mar 2013
Osteonecrosis of the Jaw and Nonmalignant Disease: Is There an Association with Rheumatoid Arthritis?
Objective To review cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) occurring in association with benign disease and to describe and compare the clinical course and outcome for patients with BRONJ and rheumatoid arthritis (RA) or osteoporosis. Methods We retrospectively reviewed observations of all..First-degree Relatives of Patients with Rheumatoid Arthritis Exhibit High Prevalence of Joint Symptoms
The Journal of Rheumatology
Mar 2013
First-degree Relatives of Patients with Rheumatoid Arthritis Exhibit High Prevalence of Joint Symptoms
Objective The preclinical period of rheumatoid arthritis (RA) is characterized by the presence of autoantibodies such as anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF). Little is known about the joint symptom profile preceding onset of RA, and whether symptoms are associated with RA..The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling
Arthritis & Rheumatism
Dec 2012
The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling
Objective: To elucidate whether the microRNA (miRNA) cluster miR-17-92 contributes to the activated phenotype of rheumatoid arthritis synovial fibroblasts (RASF). Methods: RASF were stimulated with tumor necrosis factor alpha (TNFα? and expression and regulation of the miR-17-92 cluster were studied using quantitative..TNF inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a TNF driven model of rheumatoid arthritis
Arthritis & Rheumatism
Dec 2012
TNF inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a TNF driven model of rheumatoid arthritis
Objective: To investigate how TNF inhibiting therapy effects bone destruction and inflammation in a TNF-driven animal model of rheumatoid arthritis. Methods: To evaluate the influence of TNF on osteoclastogenesis in vitro, we added different concentrations of TNF to spleen cell derived monocytes in the absence or..Circulating citrullinated vimentin fragments reflect disease burden in Ankylosing Spondylitis and has prognostic capacity for radiographic progression
Arthritis & Rheumatism
Dec 2012
Circulating citrullinated vimentin fragments reflect disease burden in Ankylosing Spondylitis and has prognostic capacity for radiographic progression
Objective: Ankylosing spondylitis (AS) is considered a seronegative disease indicated by absent or low levels of antibodies against citrullinated proteins. We evaluated whether a citrullinated and MMP degraded fragment of vimentin (VICM) could be a prognostic biomarker in AS. Methods: Serum VICM was measured in samples..The fibromyalgia family study: A genome-scan linkage study
Arthritis & Rheumatism
Dec 2012
The fibromyalgia family study: A genome-scan linkage study
Objective: Familial aggregation of fibromyalgia has been increasingly recognized. The goal of the current study was to conduct a genome wide linkage scan to identify susceptibility loci for fibromyalgia. Methods: We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free..p53 controls autoimmune arthritis via the STAT3/STAT5-mediated regulation of the Th17–Treg balance
Arthritis & Rheumatism
Dec 2012
p53 controls autoimmune arthritis via the STAT3/STAT5-mediated regulation of the Th17–Treg balance
Objective: To investigate the connection between p53 and interleukin (IL)-17–producing helper T (Th17)/regulatory T (Treg) balance in rheumatoid arthritis (RA). Methods: Th17 and Treg cell frequencies were analyzed by flow cytometry and cytokine levels in the supernatant were determined using enzyme-linked..Neutrophil cannibalismtriggers TGF-β1 production andself-regulation of neutrophil inflammatory function in MSU crystal-induced inflammation
Arthritis & Rheumatism
Dec 2012
Neutrophil cannibalismtriggers TGF-β1 production andself-regulation of neutrophil inflammatory function in MSU crystal-induced inflammation
Objectives: To identify macrophage-independent sources of transforming growth factor-β1 (TGF-β1) production during monosodium urate monohydrate (MSU) crystal-induced inflammation and determine how TGF-β1 alters MSU crystal-recruited neutrophil functions. Methods: C57BL/6J mice were injected intraperitoneally with MSU..Physical and social functioning in adolescents with rheumatological conditions: a study of predictors
Acta Paediatrica
Dec 2012
Physical and social functioning in adolescents with rheumatological conditions: a study of predictors
Aim: This study examines possible predictors of physical and social functioning in adolescents with rheumatological conditions. Condition-related variables and psychosocial variables were studied, and their relative contribution as predictors was examined. Methods: The study population was one hundred and twelve..Molecular differentiation between osteophytic and articular cartilage – clues for a transient and permanent chondrocyte phenotype
Osteoarthritis and Cartilage
Jan 2012
Molecular differentiation between osteophytic and articular cartilage – clues for a transient and permanent chondrocyte phenotype
Objective: To identify the molecular differences between the transient and permanent chondrocyte phenotype in osteophytic and articular cartilage. Methods: Total RNA was isolated from the cartilaginous layer of osteophytes and from intact articular cartilage from knee joints of 15 adult human donors and subjected to..Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells
Bone
Jan 2012
Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells
Bisphosphonates (BP) are used for the treatment of osteoporosis and bone metastases due to breast and prostate cancer. Recent clinical studies indicated a benefit in survival and tumor relapse with the supportive treatment of breast cancer using zoledronic acid (ZA), thus stimulating the debate about its putative..HFE C282Y Homozygosity Is Associated with an Increased Risk of Total Hip Replacement for Osteoarthritis
Seminars in Arthritis and Rheumatism
Dec 2011
HFE C282Y Homozygosity Is Associated with an Increased Risk of Total Hip Replacement for Osteoarthritis
Objective: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoarthritis is inconsistent. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. We examined the relationship between HFE gene mutations and risk..Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjögren's syndrome patients
Rheumatology
Nov 2011
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjögren's syndrome patients
Objectives: To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with clinical parameters such as secretion, inflammation and serology. Methods: LSG from 31 SS patients..Attainment of Inactive Disease Status Following Initiation of TNF-α Inhibitor Therapy for Juvenile Idiopathic Arthritis: Enthesitis-related Arthritis Predicts Persistent Active Disease
The Journal of Rheumatology
Nov 2011
Attainment of Inactive Disease Status Following Initiation of TNF-α Inhibitor Therapy for Juvenile Idiopathic Arthritis: Enthesitis-related Arthritis Predicts Persistent Active Disease
Objective: To analyze the attainment of inactive disease following initiation of tumor necrosis factor-α (TNF-α) inhibitors in a heterogeneous cohort of children with juvenile idiopathic arthritis (JIA). Methods: We performed retrospective chart review of all children with JIA at 1 academic center who had started TNF-α..The ClASsification for Psoriatic ARthritis (CASPAR) Criteria -- A Retrospective Feasibility, Sensitivity, and Specificity Study
The Journal of Rheumatology
Nov 2011
The ClASsification for Psoriatic ARthritis (CASPAR) Criteria -- A Retrospective Feasibility, Sensitivity, and Specificity Study
Objective: To evaluate the sensitivity, specificity, and feasibility of the ClASsification criteria for Psoriatic ARthritis (CASPAR) to retrospectively classify an existing research cohort. Methods: In total, 480 patient records were reviewed from the Royal National Hospital for Rheumatic Diseases Psoriatic Arthritis..Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China
Evidence-Based Complementary and Alternative Medicine
Aug 2011
Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China
Urtica atrichocaulis, an endemic plant to China, is commonly used to treat rheumatoid arthritis even though its pharmaceutical activities and chemical constituents were not studied. Herein, we reported our investigations on the chemical compositions of the phenolic compounds-rich fraction from U. atrichocaulis (TFUA)..Are toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromes?
Clinical and Developmental Immunology
Aug 2011
Are toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromes?
In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune..A bootstrap-based regression method for comprehensive discovery of differential gene expressions: An application to the osteoporosis study
European Journal of Medical Genetics
Jul 2011
A bootstrap-based regression method for comprehensive discovery of differential gene expressions: An application to the osteoporosis study
A common purpose of microarray experiments is to study the variation in gene expression across the categories of an experimental factor such as tissue types and drug treatments. However, it is not uncommon that the studied experimental factor is a quantitative variable rather than categorical variable. Loss of..
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