Respiratory Medical Journal Abstracts
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Safety and efficacy of paclitaxel liposome for elderly patients with advanced non-small cell lung cancer: A multi-center prospective study
Thoracic Cancer
Feb 2013
Safety and efficacy of paclitaxel liposome for elderly patients with advanced non-small cell lung cancer: A multi-center prospective study
Background: Lung cancer in elderly patients poses an increasingly challenge for oncologists. The optimal treatment needs to be explored. The purpose of this study was to evaluate the safety and efficacy of the novel form of paclitaxel liposome for elderly patients with non-small cell lung cancer (NSCLC). Methods: This..Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients
Thoracic Cancer
Feb 2013
Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients
Background: An elastofibroma is a benign, soft-tissue tumor and is important in the differential diagnosis of thoracic wall masses. Here, patients with elastofibromas who underwent thoracic surgery were retrospectively reviewed to elucidate elastofibroma formation and to facilitate the differential diagnosis. Methods:..Influence of patient characteristics on survival following treatment with helical stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer
Thoracic Cancer
Feb 2013
Influence of patient characteristics on survival following treatment with helical stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer
Background: To determine the influence of patient and tumor characteristics on clinical outcomes in patients with early-stage non-small cell lung cancer (NSCLC) treated with helical intensity modulated stereotactic body radiotherapy (SBRT). Methods: From March 2005 to August 2010 a total of 62 patients with biopsy..nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice
Thoracic Cancer
Feb 2013
nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice
Background: Lung cancer is the leading cause of cancer death in both men and women worldwide. Tumor metastasis is an essential aspect of lung cancer progression and patient death. The nm23-H1 gene has been extensively investigated as a metastasis suppressor gene. Our previous studies have revealed: that a significant..Lung cancer incidence and mortality in China, 2008
Thoracic Cancer
Feb 2013
Lung cancer incidence and mortality in China, 2008
Background: To provide cancer statistics to health planners, researchers, and the public, we reported the incidence and mortality data of lung cancer in 2008 in Chinese registration areas by age, sex, and geographic area. Methods: In 2011, 56 population-based cancer registries reported the lung cancer incidence and..Does CA125 binding to mesothelin impact the detection of malignant mesothelioma?
Lung Cancer
Jan 2013
Does CA125 binding to mesothelin impact the detection of malignant mesothelioma?
The biomarker mesothelin is a useful diagnostic tool in malignant mesothelioma (MM) patients. It has high specificity but a sensitivity of only 50%. As mesothelin binds CA125, and as CA125 is often elevated in MM, we asked whether this binding affected measurable mesothelin levels in a relevant clinical setting...Farletuzumab in lung cancer
Lung Cancer
Jan 2013
Farletuzumab in lung cancer
Folate is essential for proliferating cells and folate transport pathways and folate-dependent metabolic processes show promise as targets for anti-neoplastic therapy. Folate receptor α (FOLR1), a folate transporter, is an attractive target for anti-neoplastic therapy due to its high affinity for folate, restricted..Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients
Lung Cancer
Jan 2013
Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients
Lung adenocarcinoma is the most common type of primary lung cancer. The purpose of this study was to delineate gene expression patterns for survival prediction in lung adenocarcinoma. Gene expression profiles of 82 (discovery set) and 442 (validation set 1) lung adenocarcinoma tumor tissues were analyzed using a..Concurrent chemoradiotherapy for large-volume locally-advanced non-small cell lung cancer
Lung Cancer
Jan 2013
Concurrent chemoradiotherapy for large-volume locally-advanced non-small cell lung cancer
Purpose: Patients with large volume stage III non-small cell lung cancer (NSCLC) are often excluded from concurrent chemoradiotherapy (CRT) protocols due to fears about excessive toxicity and poor survival. Patients with N3 nodal disease may be excluded for the same reason. We have routinely accepted fit patients in..Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: Systematic review and meta-analysis of the literature
Lung Cancer
Jan 2013
Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: Systematic review and meta-analysis of the literature
Background: Not all patients with non-small cell lung carcinoma (NSCLC) have mediastinal lymph node involvement and development of less invasive methods for evaluating mediastinal lymph nodes is important. Sentinel node biopsy has been used for NSCLC since 1999 to decrease the need for mediastinal lymph node..Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer
Lung Cancer
Jan 2013
Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer
Lung cancer is sometimes difficult to differentiate from benign lung diseases expressing nodular shadow in imaging study. We assessed the diagnostic value of two commonly used tumor markers in distinguishing primary lung cancer from benign lung disease. The serum levels of carcinoembryonic antigen (CEA) and cytokeratin..Reliability of EGFR and KRAS mutation analysis on fine-needle aspiration washing in non-small cell lung cancer
Lung Cancer
Jan 2013
Reliability of EGFR and KRAS mutation analysis on fine-needle aspiration washing in non-small cell lung cancer
Introduction: Molecular profiling of advanced non-small cell lung cancer (NSCLC) has become essential for predicting customized medical treatment decision. In light of recent advances in non-invasive diagnostic procedures in NSCLC, we aimed to demonstrate the reliability of assessing molecular tests for epidermal..A randomised trial of fluticasone furoate/vilanterol (50/25 μg; 100/25 μg) on lung function in COPD
Respiratory Medicine
Jan 2013
A randomised trial of fluticasone furoate/vilanterol (50/25 μg; 100/25 μg) on lung function in COPD
Background: Fluticasone furoate (FF)/vilanterol (VI) is a novel once-daily inhaled corticosteroid/long-acting β2-agonist combination therapy for COPD. We aimed to assess the efficacy and safety of two strengths of FF/VI (100/25 μg; 50/25 μg) vs. individual components (FF 100 μg, VI 25 μg) and placebo over 24 weeks...Preventing COPD exacerbations with macrolides: A review and budget impact analysis
Respiratory Medicine
Jan 2013
Preventing COPD exacerbations with macrolides: A review and budget impact analysis
Long-term treatment with macrolides has recently been shown to reduce COPD exacerbations in doses lower than bactericidal doses. This article aims to critically review the international literature relating to the long-term effectiveness and safety of macrolides and to estimate the budget impact of preventing..Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation
Respiratory Medicine
Jan 2013
Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation
Aim: Lung function tests are essential for the diagnosis and management of bronchial asthma. Impulse oscillation (IOS) system is an alternative way to measure lung mechanics for some patients. We investigated the relative sensitivities of IOS, body plethysmography and spirometry in detecting allergen- and..Bronchiolitis in young female smokers
Respiratory Medicine
Jan 2013
Bronchiolitis in young female smokers
Background: Smoking is a growing concern among young women. However, the pulmonary effects of smoking in young female smokers in their 20's are unknown. Objective: The purpose of this study was to determine whether young female smokers demonstrate smoking-related lung abnormalities such as bronchiolitis in their 20's...Readmissions for COPD: propensity case-matched comparison between pulmonary and non-pulmonary departments
The Clinical Respiratory Journal
Jan 2013
Readmissions for COPD: propensity case-matched comparison between pulmonary and non-pulmonary departments
Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common cause of hospitalization, and the readmission rate is high. We aimed to determine whether patients discharged from a pulmonary department (PD) after an AECOPD episode had a lower COPD-related readmission rate during the next..Systemic corticosteroids for community-acquired pneumonia: Reasons for use and lack of benefit on outcome
Respirology
Jan 2013
Systemic corticosteroids for community-acquired pneumonia: Reasons for use and lack of benefit on outcome
Background and Objective: Although the benefits of systemic corticosteroids in community-acquired pneumonia (CAP) are not clear, their use is frequent in clinical practice. We described the frequency of this practice, patients' characteristics and its clinical impact. Methods: We investigated all adult CAP patients..Airway and systemic inflammation in obese children with asthma
European Respiratory Journal
Jan 2013
Airway and systemic inflammation in obese children with asthma
Obese asthma presents via altered airway and systemic inflammation in adults. This has not been comprehensively described in children. To compare airway and systemic inflammation in obese and non-obese asthmatic children and controls. In a cross-sectional study, children aged 8–17 yr were assigned to one of four..Biomarker-enhanced triage in respiratory infections – a proof-of-concept feasibility trial
European Respiratory Journal
Jan 2013
Biomarker-enhanced triage in respiratory infections – a proof-of-concept feasibility trial
Concerns about inadequate performance and complexity limit routine use of clinical risk scores in lower respiratory tract infections (LRTIs). Our aim was to study feasibility and effects of adding the biomarker proadrenomedullin (ProADM) to the CURB65 score on triage decisions and length of stay (LOS). In a randomised..3D culture model to distinguish normal from malignant human bronchial epithelial cells
European Respiratory Journal
Jan 2013
3D culture model to distinguish normal from malignant human bronchial epithelial cells
In the present study, we have developed an in vitro three-dimensional (3D) model to differentiate normal from lung cancer cells in order to study the mechanisms resulting in lung cancer. Using a reconstituted laminin-rich basement membrane (Matrigel), we were able to culture normal human bronchial epithelial cells..Impact of bronchiectasis and trapped air on quality of life and exacerbations in CF
European Respiratory Journal
Jan 2013
Impact of bronchiectasis and trapped air on quality of life and exacerbations in CF
Cystic fibrosis (CF) is primarily characterized by bronchiectasis and trapped air on chest computed tomography (CT). The Cystic Fibrosis Questionnaire-Revised Respiratory Symptoms scale (CFQ-R RSS) measures health-related quality of life. To validate bronchiectasis, trapped air and CFQ-R RSS as outcome measures, we..Fixed dose combination anti-tuberculosis therapy: a systematic review and meta-analysis
European Respiratory Journal
Jan 2013
Fixed dose combination anti-tuberculosis therapy: a systematic review and meta-analysis
Fixed-dose combination (FDC) formulations are currently recommended for treatment of active tuberculosis. We have conducted a systematic review to evaluate the risk of treatment failure or disease relapse, acquired drug resistance, bacterial conversion after two months of treatment, adverse events, adherence, and..Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: asthma versus controls
European Respiratory Journal
Jan 2013
Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: asthma versus controls
The cellular and molecular pathways in asthma are highly complex. Increased understanding can be obtained by unbiased transcriptomic analysis (RNA-Seq). We hypothesized that the transcriptomic profile of whole human endobronchial biopsies differs between asthma patients and controls. First, we investigated the..Air pollution and multiple acute respiratory outcomes
European Respiratory Journal
Jan 2013
Air pollution and multiple acute respiratory outcomes
Short-term effects of air pollutants on respiratory mortality and morbidity have been consistently reported but usually studied separately. To more completely assess air pollution effects, we studied hospitalisations for respiratory diseases together with out-of hospital respiratory deaths. A “time-stratified”..Overexpressed PC1/3 induces an epithelial-mesenchymal transition in airway epithelium
European Respiratory Journal
Jan 2013
Overexpressed PC1/3 induces an epithelial-mesenchymal transition in airway epithelium
The proprotein convertases are serine proteases responsible for the proteolytic maturation of many precursor proteins involved in upper airway remodeling during nasal polyposis. We have previously found that proprotein convertase PC1/3 is expressed in human nasal mucosa. However, whether PC1/3 is related to nasal..Thenar oxygen saturation (StO2) during weaning from mechanical ventilation: an observational study
European Respiratory Journal
Jan 2013
Thenar oxygen saturation (StO2) during weaning from mechanical ventilation: an observational study
To determine whether thenar tissue oxygen saturation (StO2) measured by non-invasive near-infrared spectroscopy, and its changes derived from an ischemic challenge, are associated to weaning outcome. Prospective observational study in a 26-bed medical-surgical intensive care unit. Patients receiving mechanical..Fine and coarse particulate air pollution in relation to respiratory health in Sweden
European Respiratory Journal
Jan 2013
Fine and coarse particulate air pollution in relation to respiratory health in Sweden
Health effects have repeatedly been associated with residential levels of air pollution. However, it is difficult to disentangle effects of long-term exposure to locally generated and long-range transported pollutants as well as of exhaust emissions and wear particles from road traffic. We aimed to investigate effects..Climate change, extreme weather events, air pollution and respiratory health in Europe
European Respiratory Journal
Jan 2013
Climate change, extreme weather events, air pollution and respiratory health in Europe
Due to climate change, air pollution patterns are changing in several urbanized areas of the world, with a significant effect on respiratory health both independently and synergistically with weather conditions; climate scenarios show Europe as one of the most vulnerable regions. European studies on heat wave episodes..TLR-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells
European Respiratory Journal
Jan 2013
TLR-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells
Haemorrhage-induced immunosuppression has been linked to nosocomial infections. We assessed the impact of MonoPhosphoryl Lipid A (MPLA), a TIR-domain-containing adaptor protein inducing Interferon-biased Toll Like Receptor 4 agonist currently used as a vaccine adjuvant in humans, on post-haemorrhage susceptibility to..Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma
Respiratory Medicine
Jan 2013
Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma
Objective: To compare the efficacy of theophylline plus salmeterol/fluticasone propionate combination product (SFC) with SFC plus placebo in asthmatic patients. Methods: In this randomized, stratified, parallel-group study, 325 patients were randomized to receive either 200 mg theophylline plus 50/250 μg SFC or placebo..A rare tumor of the lung: Pulmonary sclerosing hemangioma (pneumocytoma)
Respiratory Medicine
Jan 2013
A rare tumor of the lung: Pulmonary sclerosing hemangioma (pneumocytoma)
A 67-year-old woman was referred to our department for further evaluation of her abnormal, chest radiogram. Thorax computed tomography revealed a well-circumscribed, round mass in the middle lobe of the right lung. A thoracotomy was performed and pulmonary sclerosing hemangioma was diagnosed. We herein present a rare..Inhaler devices – From theory to practice
Respiratory Medicine
Jan 2013
Inhaler devices – From theory to practice
This brief overview of the factors determining lung deposition of aerosols provides background information required by health care providers when instructing patients to use their prescribed inhalers. We discuss differences in the optimal inhalation manoeuvres for each type of aerosol generator and the difficulties..The assessment of inspiratory muscle fatigue in healthy individuals: A systematic review
Respiratory Medicine
Jan 2013
The assessment of inspiratory muscle fatigue in healthy individuals: A systematic review
Inspiratory muscle fatigue (IMF) may contribute to the development of exercise limitation and respiratory failure. Identifying fatigue of the inspiratory muscles requires a rigorous and integrative methodological approach. However, there is no consensus about an optimal protocol to induce and assess the fatigability of..Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies
Respiratory Medicine
Jan 2013
Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies
Background: The role of lung function monitoring in subjects identified as having asymptomatic alpha-1 antitrypsin deficiency (AATD) is uncertain. We investigated for the first time the age these tests start to deviate from results expected in a healthy population with particular reference to the group with the best..Local and systemic cytokine profiles in non-severe and severe community-acquired pneumonia
European Respiratory Journal
Dec 2012
Local and systemic cytokine profiles in non-severe and severe community-acquired pneumonia
Local inflammatory responses in community-acquired pneumonia (CAP) remain insufficiently elucidated, especially in patients with non-severe CAP. In this study we determined local and systemic cytokine responses in CAP patients and correlated these with disease severity and other clinical parameters. Levels of..Hypereosinophilic obliterative bronchiolitis: a distinct, unrecognised syndrome
European Respiratory Journal
Dec 2012
Hypereosinophilic obliterative bronchiolitis: a distinct, unrecognised syndrome
Background: Only isolated biopsy-proven cases of eosinophilic bronchiolitis have been reported, all from Japan. Methods: We present 6 patients with hypereosinophilic obliterative bronchiolitis (HOB), defined by the following criteria: 1-blood eosinophil cell count>1 G·L−1 and/or BAL eosinophil count>25%, 2-persistent..Distinct TLR-mediated pathways regulate house dust mite–induced allergic disease in the upper and lower airways
Journal of Allergy and Clinical Immunology
Oct 2012
Distinct TLR-mediated pathways regulate house dust mite–induced allergic disease in the upper and lower airways
Background: Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways. In contrast to this general concept, we hypothesized that innate immunity of the upper and lower airways is respectively distinctive, because the immunologic..The Asthma Disease Activity Score: A discriminating, responsive measure predicts future asthma attacks
Journal of Allergy and Clinical Immunology
Oct 2012
The Asthma Disease Activity Score: A discriminating, responsive measure predicts future asthma attacks
Background: Classifying asthma severity or activity has evolved, but there are no published weighted composite measures of asthma disease activity that account for the relative importance of the many individual clinical variables that are widely used. Objectives: We sought to develop a weighted and responsive measure..Epigenetic mechanisms and the development of asthma
Journal of Allergy and Clinical Immunology
Oct 2012
Epigenetic mechanisms and the development of asthma
Asthma is heritable, influenced by the environment, and modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Furthermore, the transcription factors that are involved in the development of mature T cells that are critical to the TH2 immune phenotype in asthmatic..Asthma Symptom Utility Index: Reliability, validity, responsiveness, and the minimal important difference in adult asthmatic patients
Journal of Allergy and Clinical Immunology
Oct 2012
Asthma Symptom Utility Index: Reliability, validity, responsiveness, and the minimal important difference in adult asthmatic patients
Background: The evaluation of asthma symptoms is a core outcome measure in asthma clinical research. The Asthma Symptom Utility Index (ASUI) was developed to assess the frequency and severity of asthma symptoms. The psychometric properties of the ASUI are not well characterized, and a minimal important difference (MID)..Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma
Journal of Allergy and Clinical Immunology
Sep 2012
Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma
Background: Protectin D1 (PD1) is an anti-inflammatory and proresolving lipid mediator biosynthesized from the omega-3 fatty acid docosahexaenoic acid (DHA). Exogenous PD1 conferred protection against eosinophilic inflammation in animals with experimental asthma, although its endogenous cellular source and functions in..Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17
Journal of Allergy and Clinical Immunology
Sep 2012
Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17
Background: Studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic inflammation, but in vivo evidence for this phenotype in human asthma is lacking. Objective: To characterize the phenotype of lung macrophages from asthmatic..Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma
Journal of Allergy and Clinical Immunology
Sep 2012
Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma
Background: Asthma is a chronic inflammatory disease characterized by airways hyperresponsiveness (AHR), reversible airflow obstruction, airway remodeling, and episodic exacerbations caused by air pollutants, such as particulate matter (PM; PM <2.5 μm in diameter [PM2.5]) and ozone (O3). Spleen tyrosine kinase (Syk),..Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma
Journal of Allergy and Clinical Immunology
Sep 2012
Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma
Background: Impaired immune response to viral infections in atopic asthmatic patients has been recently reported and debated. Whether this condition is present in childhood and whether it is affected by atopy per se deserves further investigation. Objective: We sought to investigate airway interferon production in..Chronic obstructive pulmonary disease and cancer risk: A Danish nationwide cohort study
Respiratory Medicine
Jan 2012
Chronic obstructive pulmonary disease and cancer risk: A Danish nationwide cohort study
Introduction: Little is known about the risk of cancer in patients with chronic obstructive pulmonary disease (COPD), including which cancer sites are most affected. We examined the short- and long-term risk of lung and extrapulmonary cancer in a nationwide cohort of COPD patients. Methods: We linked the Danish..Characterisation of asthma that develops during adolescence; findings from the Isle of Wight Birth Cohort
Respiratory Medicine
Jan 2012
Characterisation of asthma that develops during adolescence; findings from the Isle of Wight Birth Cohort
Background: Understanding of adolescent-onset asthma remains limited. We sought to characterise this state and identify associated factors within a longitudinal birth cohort study. Methods: The Isle of Wight Whole Population Birth Cohort was recruited in 1989 (N=1456) and characterised at 1, 2, 4, 10 and 18-years...Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations
Respiratory Medicine
Dec 2011
Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations
Background: Recent studies have shown that neurogenic inflammation induced by cigarette smoke is inhibited by TRPA1 antagonist, but not by TRPV1 antagonist. Since cough reflex sensitivity is known to be modified by smoking status, we investigated the effects of cigarette smoking on TRPA1- and TRPV1-induced cough and..Targeting EGFR in non-small-cell lung cancer: Lessons, experiences, strategies
Respiratory Medicine
Nov 2011
Targeting EGFR in non-small-cell lung cancer: Lessons, experiences, strategies
Cancer is a genetic disease and this concept is now widely exploited by both scientists and clinicians to design new targeted molecules. Indeed many data have already allowed us to ameliorate not only our knowledge about cancer onset, but also about patients treatment. Correlation between mutations in cancer alleles..Ventilation perfusion lung scan in pulmonary veno-occlusive disease
European Respiratory Journal
Nov 2011
Ventilation perfusion lung scan in pulmonary veno-occlusive disease
Pulmonary veno-occlusive disease (PVOD), a rare form of pulmonary arterial hypertension (PAH) requires histological proof for definitive diagnosis; however lung biopsy is not recommended in PAH. Recent conjoint ERS/ESC guidelines, suggest that unmatched perfusion defects on ventilation/perfusion (V/Q) lung scan, in PAH..Early detection of COPD is important for lung cancer surveillance
European Respiratory Journal
Nov 2011
Early detection of COPD is important for lung cancer surveillance
It is well known that chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. Approximately 1% of COPD patients develop lung cancer every year, which may be associated with genetic susceptibility to cigarette smoke. Chronic inflammation caused by toxic gases can induce COPD and lung..Lipoplatin Formulation Review Article
Journal of Drug Delivery
Aug 2011
Lipoplatin Formulation Review Article
Patented platform technologies have been used for the liposomal encapsulation of cisplatin (Lipoplatin) into tumor-targeted 110 nm (in diameter) nanoparticles. The molecular mechanisms, preclinical and clinical data concerning lipoplatin, are reviewed here. Lipoplatin has been successfully administered in three..Extravascular Lung Water and Acute Lung Injury
Cardiology Research and Practice
Aug 2011
Extravascular Lung Water and Acute Lung Injury
Acute lung injury carries a high burden of morbidity and mortality and is characterised by nonhydrostatic pulmonary oedema. The aim of this paper is to highlight the role of accurate quantification of extravascular lung water in diagnosis, management, and prognosis in “acute lung injury” and “acute respiratory distress..Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease
Journal of Allergy
Aug 2011
Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease
Aspirin-exacerbated respiratory disease (AERD) refers to the development of bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs. The key pathogenic mechanisms associated with AERD are the overproduction of cysteinyl leukotrienes (CysLTs) and increased..
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