The Pharmacokinetics and Pharmacogenetics of the Antiemetic Cyclizine in Palliative Care PatientsContext: Cyclizine, an antihistaminic antiemetic, is commonly used in palliative care. Its pharmacokinetics have been poorly studied, and its metabolic pathway is unknown but may involve the genetically controlled cytochrome P450 2D6 (CYP2D6). If this is the case, the metabolic ratio of cyclizine to norcyclizine and..
European Journal of Cancer
Decision-making in the end-of-life phase of high-grade glioma patientsBackground: During the disease course of high-grade glioma (HGG) patients, the goal of therapy eventually shifts from primarily life-prolongation to primarily sustaining the quality of life as good as possible. End-of-life care is aimed at prolongation of life with good quality, but inevitably also may require medical..
The Lack of Standard Definitions in the Supportive and Palliative Oncology LiteratureContext: Multiple organizations have raised concerns about the lack of standard definitions for terminology in the supportive and palliative oncology literature. Objectives: We aimed to determine 1) the frequency of 10 commonly used terms in the supportive and palliative oncology literature, 2) the proportion of..
The modern staged repair of classic bladder exstrophy: A detailed postoperative management strategy for primary bladder closure
Journal of Pediatric Urology
The modern staged repair of classic bladder exstrophy: A detailed postoperative management strategy for primary bladder closurePurpose: Successful primary bladder closure of classic bladder exstrophy sets the stage for development of adequate bladder capacity and eventual voided continence. The postoperative pathway following primary bladder closure at the authors’ institution is quantitatively and qualitatively detailed. Materials and..
Quality of Life and Experience of Care in Women With Metastatic Breast Cancer: A Cross-Sectional Survey
Quality of Life and Experience of Care in Women With Metastatic Breast Cancer: A Cross-Sectional SurveyContext: Despite developments in the medical management of metastatic breast cancer, little is known about the quality of life (QoL) and experience of care in women with it. Objectives: To explore QoL, experience of care, and support needs of women living with metastatic breast cancer in the U.K. Methods:..
Impact of Infections on the Survival of Hospitalized Advanced Cancer PatientsContext: Advanced cancer patients remain highly susceptible to infections, leading to significant morbidity and mortality. A lack of consensus on the management of infections in this population stems from the heterogeneity of the patient group, divergent goals of care, and unknown prognosis with antibiotic treatment...
Creative Solution for Implementation of Experiential, Competency-Based Palliative Care Training for Internal Medicine Residents
Journal of Cancer Education
Creative Solution for Implementation of Experiential, Competency-Based Palliative Care Training for Internal Medicine ResidentsTo graduate internal medicine residents with basic competency in palliative care, we employ a two-pronged strategy targeted at both residents and attending physicians as learners. The first prong provides a knowledge foundation using web-based learning programs designed specifically for residents and clinical faculty..
Congestive Heart Failure
Ethics in the Treatment of Advanced Heart Failure: Palliative Care and End-of-Life IssuesAdvanced heart failure (HF) is a life-shortening condition, yet there are increasing treatments and implantable devices available to clinicians to manage patients with advanced HF. Planning for adverse events and the end of life, formulated as “preparedness planning,” can be integrated into HF care early in illness...
Late referrals to home palliative care service affecting death at home in advanced cancer patients in Japan: a nationwide survey
Annals of Oncology
Late referrals to home palliative care service affecting death at home in advanced cancer patients in Japan: a nationwide surveyBackground: To identify factors influencing place of death among home palliative care patients with advanced cancer, focusing on the timing of referrals from hospital to home care settings. Methods: A cross-sectional nationwide questionnaire survey was conducted on home palliative care patients at 1000 randomly..