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Bone mass density, fracture history, self-reported osteoporosis as proxy variables for estrogen and the risk of non-small-cell lung cancer—A population based cohort study, the HUNT study: Are proxy variables friends or faults?
Lung Cancer
Apr 2013
Bone mass density, fracture history, self-reported osteoporosis as proxy variables for estrogen and the risk of non-small-cell lung cancer—A population based cohort study, the HUNT study: Are proxy variables friends or faults?
Lung cancer has the highest mortality of all cancers. Patients with early stage disease have the best cure rates and that emphasizes the importance of early detection. About half of all non-small cell lung cancers (NSCLC) are estrogen receptor positive. The impact of estrogen and its receptors for NSCLC carcinogenesis..Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: A systematic review with meta-analysis
Lung Cancer
Apr 2013
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: A systematic review with meta-analysis
K-RAS gene mutations have been found in 20–30% of non-small cell lung cancer and occur most commonly in adenocarcinoma, however, there was no definitive conclusion about the prognostic role of K-RAS mutations in NSCLC. Herein we performed a systematic review of the literatures with meta-analysis to assess K-RAS..Incidence of Skeletal-related Events Over Time from Solid Tumour Bone Metastases Reported in Randomised Trials Using Bone-modifying Agents
Clinical Oncology
Apr 2013
Incidence of Skeletal-related Events Over Time from Solid Tumour Bone Metastases Reported in Randomised Trials Using Bone-modifying Agents
Aims: Skeletal-related events (SREs) in patients with bone metastases decrease a patient's quality of life and functional status. Although bone-modifying agents have been found to reduce the time to first on-trial SRE and decrease the total incidence of SREs in randomised clinical trials, standard practice in the..Clinical applicability of staging small cell lung cancer according to the seventh edition of the TNM staging system
Lung Cancer
Mar 2013
Clinical applicability of staging small cell lung cancer according to the seventh edition of the TNM staging system
The two-stage system of limited and extensive disease has been widely employed for small cell lung cancer (SCLC). However, the International Association for the Study of Lung Cancer has proposed that the TNM classification should be incorporated into clinical practice. The purpose of this study was to evaluate the..Pemetrexed-induced neutropenic enteritis and severe cutaneous hyperpigmentation in a patient with malignant pleural mesothelioma
Lung Cancer
Mar 2013
Pemetrexed-induced neutropenic enteritis and severe cutaneous hyperpigmentation in a patient with malignant pleural mesothelioma
Neutropenic enteritis (NE) or enterocolitis (NEC) is a rare, but potentially life-threatening side effect of neutropenia-inducing chemotherapy agents. Generally, its occurrence is attributed to leukemia-associated chemotherapies. Two cases of NE have been reported after the appliance of pemetrexed for treatment of..Oesophageal Chemoradiotherapy in the UK—Current Practice and Future Directions
Clinical Oncology
Mar 2013
Oesophageal Chemoradiotherapy in the UK—Current Practice and Future Directions
The SCOPE 1 trial closed to recruitment in early 2012 and has demonstrably improved the quality of UK radiotherapy. It has also shown that there is an enthusiastic upper gastrointestinal clinical oncology community that can successfully complete trials and deliver high-quality radiotherapy. Following on from SCOPE 1,..Early Cardiac Outcomes Following Contemporary Treatment for Childhood Acute Myeloid Leukemia: A North American Perspective
Pediatric Blood & Cancer
Feb 2013
Early Cardiac Outcomes Following Contemporary Treatment for Childhood Acute Myeloid Leukemia: A North American Perspective
Background: Anthracycline agents are used for treatment of acute myeloid leukemia (AML) but may cause late-onset cardiomyopathy. Current frontline therapy for AML in North America, as reflected in the approach of the Children's Oncology Group (COG) and other pediatric consortia, is adapted from the..SIOP PODC: Recommendations for Supportive Care of Children With Cancer in a Low-Income Setting
Pediatric Blood & Cancer
Feb 2013
SIOP PODC: Recommendations for Supportive Care of Children With Cancer in a Low-Income Setting
These supportive care recommendations were prepared to guide doctors who practice in areas with significantly limited resources but who have sufficient infrastructure and training to treat children with cancer with curative intent. The success of any cancer treatment regimen depends largely on the availability and..Patient-Perceived Facilitators in the Transition of Care for Young Adult Survivors of Childhood Cancer
Pediatric Blood & Cancer
Feb 2013
Patient-Perceived Facilitators in the Transition of Care for Young Adult Survivors of Childhood Cancer
Background. A new challenge has emerged in optimizing the transition of pediatric survivorship care to similarly focused programs that are age-appropriate for young adults. The purpose of this study is to identify components of a clinical survivorship program that facilitate the transition of care for young adult..Annual number of lung cancer deaths potentially avertable by screening in the United States
Cancer
Feb 2013
Annual number of lung cancer deaths potentially avertable by screening in the United States
Background: The National Lung Screening Trial (NLST), which was conducted between 2002 and 2009, demonstrated that screening with low-dose computed tomography (LDCT) reduced lung cancer mortality by 20% among screening-eligible populations compared with chest x-ray. In this article, the authors provide an estimate of..Patient-reported outcomes after 3-dimensional conformal, intensity-modulated, or proton beam radiotherapy for localized prostate cancer
Cancer
Feb 2013
Patient-reported outcomes after 3-dimensional conformal, intensity-modulated, or proton beam radiotherapy for localized prostate cancer
Background: Recent studies have suggested differing toxicity patterns for patients with prostate cancer who receive treatment with 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), or proton beam therapy (PBT). Methods: The authors reviewed patient-reported outcomes data collected..Xeroderma pigmentosum genes and melanoma risk
International Journal of Cancer
Feb 2013
Xeroderma pigmentosum genes and melanoma risk
This is the first large case-control study that evaluates the association of 94 XP SNPs with malignant melanoma risk in Slavic (Polish) population. The paper adds important results to the growing but still not completely consistent literature data regarding XP changes and melanoma risk. Xeroderma pigmentosum is a rare..Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells
International Journal of Cancer
Feb 2013
Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells
Ovarian cancer ranks fifth in cancer fatalities among American women. Although curable at early stages with surgery, most women are diagnosed with symptoms of late-stage metastatic disease. Moreover, none of the current diagnostic techniques are clinically recommended for at-risk women as they preferentially target..HOXA9, ISL1, and ALDH1A3 methylation patterns as prognostic markers for non-muscle invasive bladder cancer: Array-based DNA methylation and expression profiling
International Journal of Cancer
Feb 2013
HOXA9, ISL1, and ALDH1A3 methylation patterns as prognostic markers for non-muscle invasive bladder cancer: Array-based DNA methylation and expression profiling
DNA methylation patterns are associated with the development and prognosis of cancer. The aim of the present study was to identify novel methylation markers for the prediction of patient outcomes using microarray analysis of DNA methylation and RNA expression patterns in samples from long-term follow-up patients with..Long-term regional control in the observed neck following definitive chemoradiation for node-positive oropharyngeal squamous cell cancer
International Journal of Cancer
Feb 2013
Long-term regional control in the observed neck following definitive chemoradiation for node-positive oropharyngeal squamous cell cancer
Traditionally, patients treated with chemoradiotherapy for node-positive oropharyngeal squamous cell carcinoma (N+ OPSCC) have undergone a planned neck dissection (ND) after treatment. Recently, negative post-treatment positron-emission tomography (PET)/computed tomography (CT) imaging has been found to have a high..Timing of Curative Treatment for Prostate Cancer: A Systematic Review
European Urology
Feb 2013
Timing of Curative Treatment for Prostate Cancer: A Systematic Review
Context: Delaying definitive therapy unfavourably affects outcomes in many malignancies. Diagnostic, psychological, and logistical reasons but also active surveillance (AS) strategies can lead to treatment delay, an increase in the interval between the diagnosis and treatment of prostate cancer (PCa). Objective: To..Androgen-deprivation Therapy and Diabetes Control Among Diabetic Men with Prostate Cancer
European Urology
Feb 2013
Androgen-deprivation Therapy and Diabetes Control Among Diabetic Men with Prostate Cancer
Background: Androgen-deprivation therapy (ADT) for prostate cancer (PCa) is associated with decreased insulin sensitivity and increased diabetes risk among nondiabetic men. Few data are available about the effects of ADT on diabetes control among men with diabetes. Objective: We examined care for men who had diabetes..Evaluation of 5-year imatinib treatment of 458 patients with CP-CML in routine clinical practice and prognostic impact of different BCR-ABL cutoff levels
Cancer Medicine
Feb 2013
Evaluation of 5-year imatinib treatment of 458 patients with CP-CML in routine clinical practice and prognostic impact of different BCR-ABL cutoff levels
We evaluated responses to the treatment and long-term outcomes of chronic myeloid leukemia patients treated with imatinib as first-line treatment in routine clinical setting from two countries with centralized tyrosine kinase inhibitors (TKIs) treatment. We assessed prognostic significance of European LeukemiaNet (ELN)..Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: A systematic review
Cancer Treatment Reviews
Feb 2013
Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: A systematic review
Background and aims; The use of oral anticancer drugs has increased in modern oncology treatment. The move from intravenous treatments towards oral anticancer drugs has increased the patients’ own responsibility to take oral anticancer drugs as being prescribed. High rates of non-adherence to oral anticancer drugs have..HER2-targeted therapy in breast cancer: A systematic review of neoadjuvant trials
Cancer Treatment Reviews
Feb 2013
HER2-targeted therapy in breast cancer: A systematic review of neoadjuvant trials
Targeting human epidermal growth factor receptor 2 (HER2) during or in sequence with chemotherapy improves overall survival in metastatic and early HER2-overexpressing breast cancer. In this paper we systematically review neoadjuvant clinical trial data in HER2-positive breast cancer and discuss key unanswered clinical..Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities
Cancer Treatment Reviews
Feb 2013
Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities
By the introduction of molecularly targeted anti-cancer drugs, that are designed to intervene with specific pathways aberrant in cancers with distinct mutations, the type of adverse events encountered has changed greatly compared to the adverse events profile of classical chemotherapeutic agents. Ocular toxicities,..Revisiting ovarian cancer preclinical models: Implications for a better management of the disease
Cancer Treatment Reviews
Feb 2013
Revisiting ovarian cancer preclinical models: Implications for a better management of the disease
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite progress in identifying “hallmark” genetic alterations associated with the main subtypes of epithelial ovarian cancer, the survival rate of women with EOC changed little since platinum-based treatment was introduced more than 30years..Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer
Cancer
Feb 2013
Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer
Background: Increased pathologic complete response (pCR) rates observed with neoadjuvant chemotherapy (NCT) for some subsets of patients with invasive breast cancer have prompted interest in whether patients who achieved a pCR can be identified preoperatively and potentially spared the morbidity of surgery. The..RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics
Cancer
Feb 2013
RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics
Background: Childhood exposure to iodine-131 from the 1986 nuclear accident in Chernobyl, Ukraine, led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data concerning the association between genetic mutations in PTCs and individual radiation doses are limited...Birth rates among female cancer survivors
Cancer
Feb 2013
Birth rates among female cancer survivors
Background: More women of fertile age are long-term survivors of cancer. However, population-based data on birth rates of female cancer survivors are rare. Methods: A total of 42,691 women ≤ 45 years with a history of cancer were identified from the Swedish Multi-Generation Register and the Swedish Cancer Register, for..Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States
Cancer
Feb 2013
Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States
Background: Clinical trials in pediatric acute myeloid leukemia (AML) determine induction regimen standards. However, these studies lack the data necessary to evaluate mortality trends over time and differences in resource utilization between induction regimens. Moreover, these trials likely underreport the clinical..Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program
Cancer
Feb 2013
Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program
Background: Nasopharyngeal carcinoma (NPC) is prevalent in Southeast Asia. Over the last decade, plasma Epstein-Barr virus (EBV) DNA has been developed as a tumor marker for NPC. In this study, the authors investigated whether plasma EBV DNA analysis is useful for NPC surveillance. Methods: In total, 1318 volunteers..Does obesity affect the accuracy of prostate-specific antigen (PSA) for predicting prostate cancer among men undergoing prostate biopsy
BJU International
Feb 2013
Does obesity affect the accuracy of prostate-specific antigen (PSA) for predicting prostate cancer among men undergoing prostate biopsy
What's known on the subject? and What does the study add? As most urologist known, obesity significantly lowers serum PSA levels. So there is some concern about delayed diagnosis of prostate cancer in obese men. In the present study, we found that the accuracy level of PSA for detecting prostate cancer was not..Does Positive Family History of Prostate Cancer Increase the Risk of Prostate Cancer on Initial Prostate Biopsy?
Urology
Feb 2013
Does Positive Family History of Prostate Cancer Increase the Risk of Prostate Cancer on Initial Prostate Biopsy?
Objective: To assess the role of family history (FH) in the risk of a positive prostate biopsy (PBx) in a large North American biopsy population as earlier reports showed increased risk of prostate cancer (PCa) in men with a FH, but the risk has been limited to low grade prostate cancer in smaller studies, and the..Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial
The Lancet
Feb 2013
Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial
Background: Rituximab plus chemotherapy, most often CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), is the first-line standard of care for patients with advanced indolent lymphoma, and for elderly patients with mantle-cell lymphoma. Bendamustine plus rituximab is effective for relapsed or refractory..Design and conduct of early clinical studies of two or more targeted anticancer therapies: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies
European Journal of Cancer
Feb 2013
Design and conduct of early clinical studies of two or more targeted anticancer therapies: Recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies
The Methodology for the Development of Innovative Cancer Therapies (MDICT) task force considered aspects of the design and conduct of early (phase I and II) studies of combinations of molecular targeted agents during their 2012 meeting. The task force defined necessary non-clinical data, such as evidence of additive or..Risk Adopted Allogeneic Hematopoietic Stem Cell Transplantation Using a Reduced Intensity Regimen for Children with Thalassemia Major
Pediatric Blood & Cancer
Feb 2013
Risk Adopted Allogeneic Hematopoietic Stem Cell Transplantation Using a Reduced Intensity Regimen for Children with Thalassemia Major
Background: Patients with thalassemia in developing countries have limited access to safe transfusions, regular medical care and chelation therapy. Although allogeneic hematopoietic stem cell transplantation (HSCT) can offer a curative approach, there are limited data on the use of this procedure in developing..Screening for distress in cancer patients
Cancer
Feb 2013
Screening for distress in cancer patients
Background: Routine screening for distress is internationally recommended as a necessary standard for good cancer care, given its high prevalence and negative consequences on quality of life. The objective of the current study was to contribute to the Italian validation of the Distress Thermometer (DT) to determine..Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis
Cancer
Feb 2013
Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis
Background: Bone marrow (BM) biopsies from patients with chronic lymphocytic leukemia (CLL) may show reticulin fibrosis at diagnosis, but its significance remains unclear. This study sought to assess the prognostic impact of BM reticulin fibrosis in patients with previously untreated CLL. Methods: Data was reviewed..Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma
Cancer
Feb 2013
Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma
Background: This study sought to determine if preoperative image-guided intensity-modulated radiotherapy (IG-IMRT) can reduce morbidity, including wound complications, by minimizing dose to uninvolved tissues in adults with lower extremity soft tissue sarcoma. Methods: The primary endpoint was the development of an..Modulation of c-Met signaling and cellular sensitivity to radiation
Cancer
Feb 2013
Modulation of c-Met signaling and cellular sensitivity to radiation
The c-Met/hepatocyte growth factor receptor and its family members are known to promote cancer cell migration and invasion. Signaling within and beyond this pathway contributes to the systemic spread of metastases through induction of the epithelial-mesenchymal transition, a process also implicated in mediating..Synchronous cancers in patients with head and neck cancer
Cancer
Feb 2013
Synchronous cancers in patients with head and neck cancer
Background: Second primary malignancies (SPMs) are the leading cause of death in survivors of head and neck squamous cell carcinoma (HNSCC). Synchronous SPMs are of significant clinical interest because they potentially can be identified by screening procedures at the time of diagnosis of the index cancer. Recently,..Coregistered whole body magnetic resonance imaging-positron emission tomography (MRI-PET) versus PET-computed tomography plus brain MRI in staging resectable lung cancer
Cancer
Feb 2013
Coregistered whole body magnetic resonance imaging-positron emission tomography (MRI-PET) versus PET-computed tomography plus brain MRI in staging resectable lung cancer
Background: The objective of this study was to assess whether coregistered whole brain (WB) magnetic resonance imaging-positron emission tomography (MRI-PET) would increase the number of correctly upstaged patients compared with WB PET-computed tomography (PET-CT) plus dedicated brain MRI in patients with nonsmall cell..Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: Long term results of the Italian Tamoxifen Anastrozole trial
European Journal of Cancer
Feb 2013
Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: Long term results of the Italian Tamoxifen Anastrozole trial
The Italian Tamoxifen Anastrozole (ITA) trial investigated the efficacy of switching to anastrozole for women who were already on adjuvant tamoxifen since 2–3years. Relapse-free survival (RFS) was the primary end-point; event-free survival (EFS), overall survival (OS) and safety were secondary end-points. Herein, we..Awareness of General Practitioners concerning cancer patients’ preferences for place of death: Evidence from four European countries
European Journal of Cancer
Feb 2013
Awareness of General Practitioners concerning cancer patients’ preferences for place of death: Evidence from four European countries
Background: General Practitioners (GPs) are at the first level of contact in many European healthcare systems and they supposedly have a role in supporting cancer patients in achieving their desired place of death. A four-country (Belgium, the Netherlands, Italy and Spain) study was carried out exploring current..Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases
European Journal of Cancer
Feb 2013
Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases
Aim: The CHEK2∗1100delC mutation confers a relative risk of two for breast cancer (BC) in the general population. This study aims to explore the excess cancer risk due to the CHEK2∗1100delC mutation within a familial non-BRCA1/2 breast cancer setting. Patients and Methods: Cancer incidences were compared between first..Second cranio-facial malignancies in hereditary retinoblastoma survivors previously treated with radiation therapy: Clinic and radiologic characteristics and survival outcomes
European Journal of Cancer
Feb 2013
Second cranio-facial malignancies in hereditary retinoblastoma survivors previously treated with radiation therapy: Clinic and radiologic characteristics and survival outcomes
Introduction: Hereditary retinoblastoma survivors have an increased risk for cranio-facial second primary tumours (SPT), especially after treatment with external beam radiotherapy (EBRT). This multicentre study evaluates the clinical and imaging characteristics and outcomes of cranio-facial SPTs in irradiated..Medium-term Outcomes of Active Surveillance for Localised Prostate Cancer
European Urology
Feb 2013
Medium-term Outcomes of Active Surveillance for Localised Prostate Cancer
Background: Active surveillance (AS) aims to allow men with favourable-risk, localised prostate cancer to avoid unnecessary treatment. Objective: To describe the clinical outcomes of a prospective study of AS. Design, setting, and participants: A single-centre, prospective cohort study. Eligibility criteria included..Topography of Lymph Node Metastases in Prostate Cancer Patients Undergoing Radical Prostatectomy and Extended Lymphadenectomy: Results of a Combined Molecular and Histopathologic Mapping Study
European Urology
Feb 2013
Topography of Lymph Node Metastases in Prostate Cancer Patients Undergoing Radical Prostatectomy and Extended Lymphadenectomy: Results of a Combined Molecular and Histopathologic Mapping Study
Background: To determine the anatomic extent of pelvic lymph node dissection (PLND) in prostate cancer (PCa) patients at the time of radical prostatectomy (RP), knowledge about the topography of lymph node (LN) metastases is required. Objective: Because small-volume LN metastases may be missed by standard..Incidence And Pathologic Features Of Prostate Cancer Detected On Transperineal Template-Guided Mapping Biopsy Following Negative Transrectal Ultrasound-Guided Biopsy
Journal of Urology
Feb 2013
Incidence And Pathologic Features Of Prostate Cancer Detected On Transperineal Template-Guided Mapping Biopsy Following Negative Transrectal Ultrasound-Guided Biopsy
Purpose: To determine the incidence of cancer detection with transperineal template-guided mapping biopsy (TTMB) of the prostate in patients having at least one previously negative transrectal ultrasound-guided (TRUS) biopsy. Materials and Methods: From January 2005 – January 2012, 485 patients in our clinical database..Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial
The Lancet
Feb 2013
Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial
Background: Colonoscopy is the gold-standard test for investigation of symptoms suggestive of colorectal cancer; computed tomographic colonography (CTC) is an alternative, less invasive test. However, additional investigation after CTC is needed to confirm suspected colonic lesions, and this is an important factor in..High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity
European Journal of Cancer
Feb 2013
High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity
Background: The transcription factor sex determining region Y (SRY)-box 2 (SOX2) (3q26.3–q27) has been recently identified as a recurrently activated major oncogene in squamous cell carcinoma of various sites. Its prognostic value in head and neck squamous cell carcinoma (HNSCC) is currently unclear. Aim: To correlate..Manual Repositioning of Intra-atrial Kidney Cancer Tumor Thrombus: A Technique Reducing the Need for Cardiopulmonary Bypass
Urology
Feb 2013
Manual Repositioning of Intra-atrial Kidney Cancer Tumor Thrombus: A Technique Reducing the Need for Cardiopulmonary Bypass
Objective: To describe a feasible surgical technique for patients with renal cell carcinoma associated with a supradiaphragmatic tumor thrombus that avoids cardiopulmonary bypass procedure. Materials and Methods: From 2004 to 2009, 4 patients with a right kidney tumor and tumor thrombus above the diaphragm (pT3c)..Patterns and Predictors of Amelioration of Genitourinary Toxicity After High-dose Intensity-modulated Radiation Therapy for Localized Prostate Cancer: Implications for Defining Postradiotherapy Urinary Toxicity
European Urology
Feb 2013
Patterns and Predictors of Amelioration of Genitourinary Toxicity After High-dose Intensity-modulated Radiation Therapy for Localized Prostate Cancer: Implications for Defining Postradiotherapy Urinary Toxicity
Background: Treatment-related toxicity and quality of life (QoL) considerations are important when counseling patients with localized prostate cancer (PCa). Objective: To determine the incidence and longitudinal pattern of late genitourinary (GU) toxicity and QoL after high-dose, intensity-modulated radiotherapy..Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial
The Lancet Oncology
Feb 2013
Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial
Background: Insulin-like growth factors (IGF-1 and IGF-2) bind to the IGF-1 receptor (IGF-1R), increasing cell proliferation and survival. Ganitumab is a monoclonal IgG1 antibody that blocks IGF-1R. We tested the efficacy and safety of adding ganitumab to endocrine treatment for patients with hormone-receptor-positive..Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial
The Lancet Oncology
Feb 2013
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial
Background: The relative efficacy of the addition of induction chemotherapy to chemoradiotherapy compared with chemoradiotherapy alone for patients with head and neck cancer is unclear. The PARADIGM study is a multicentre open-label phase 3 study comparing the use of docetaxel, cisplatin, and fluorouracil (TPF)..CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01)
The Lancet Oncology
Feb 2013
CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01)
Background: Several randomised trials have confirmed the benefit of adjuvant trastuzumab for patients with HER2-positive early breast cancer. However, concern has been expressed that adjuvant trastuzumab might be associated with an increased frequency of CNS relapses. We assessed the frequency and course of CNS..MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
The Lancet Oncology
Feb 2013
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
Background: Patients with melanoma harbouring Val600 BRAF mutations benefit from treatment with BRAF inhibitors. However, no targeted treatments exist for patients with BRAF wild-type tumours, including those with NRAS mutations. We aimed to assess the use of MEK162, a small-molecule MEK1/2 inhibitor, in patients with..Evolution and outcomes of 3 MHz High intensity focused ultrasound therapy for localized prostate cancer over 15 years
Journal of Urology
Feb 2013
Evolution and outcomes of 3 MHz High intensity focused ultrasound therapy for localized prostate cancer over 15 years
Purpose: To describe the long-term cancer control and morbidity of high intensity focused ultrasound (HIFU) with neoadjuvant transurethral resection of the prostate (TURP), the risk of metastatic induction by TURP and the evolution of HIFU application and technology over time. Patients and Methods: Prospective..Nine-Year Outcome and Toxicity in Patients treated with IMRT for Localized Prostate Cancer
Journal of Urology
Feb 2013
Nine-Year Outcome and Toxicity in Patients treated with IMRT for Localized Prostate Cancer
Purpose: To evaluate long-term disease control and chronic toxicities observed in patients treated with intensity-modulated radiation therapy (IMRT) for clinically localized prostate cancer. Methods/Materials: 302 patients with localized prostate cancer treated with image guided IMRT between 7/2000 and 5/2005 were..Androgen-deprivation Therapy in Treatment of Prostate Cancer and Risk of Myocardial Infarction and Stroke: A Nationwide Danish Population-based Cohort Study
European Urology
Feb 2013
Androgen-deprivation Therapy in Treatment of Prostate Cancer and Risk of Myocardial Infarction and Stroke: A Nationwide Danish Population-based Cohort Study
Background: Androgen-deprivation therapy (ADT) has been suggested to increase the risk for cardiovascular diseases, including myocardial infarction (MI) and stroke, but data are inconsistent. Objectives: To investigate the association between ADT and risk for MI and stroke in Danish men with prostate cancer. Design,..Androgen-deprivation Therapy and Risk for Biliary Disease in Men with Prostate Cancer
European Urology
Feb 2013
Androgen-deprivation Therapy and Risk for Biliary Disease in Men with Prostate Cancer
Background: Androgen-deprivation therapy (ADT) by either a gonadotropin-releasing hormone (GnRH) agonist or bilateral orchiectomy improves disease-related outcomes of men with prostate cancer but has a variety of adverse metabolic effects including obesity, increased abdominal girth, increased triglycerides, and..Effect of Practice Integration between Urologists and Radiation Oncologists on Prostate Cancer Treatment Patterns
Journal of Urology
Feb 2013
Effect of Practice Integration between Urologists and Radiation Oncologists on Prostate Cancer Treatment Patterns
Purpose: National attention has focused on whether urology-radiation oncology practice integration – known as integrated prostate cancer centers (IPCCs) – contributes to use of intensity-modulated radiation therapy (IMRT), a common and expensive treatment for prostate cancer. Methods: We examined prostate cancer..Testosterone Replacement Therapy in Patients with Prostate Cancer After Radical Prostatectomy
Journal of Urology
Feb 2013
Testosterone Replacement Therapy in Patients with Prostate Cancer After Radical Prostatectomy
Purpose: Testosterone replacement therapy in men with prostate cancer is controversial, with concern that testosterone can stimulate cancer growth. We evaluated the safety and efficacy of testosterone in hypogonadal men with prostate cancer treated with radical prostatectomy. Materials and Methods: Review of 103..Fiber-substituted Conditionally Replicating Adenovirus Ad5F35 Induces Oncolysis of Human Bladder Cancer Cells in In Vitro Analysis
Urology
Feb 2013
Fiber-substituted Conditionally Replicating Adenovirus Ad5F35 Induces Oncolysis of Human Bladder Cancer Cells in In Vitro Analysis
Objective: To assess the oncolytic effect of fiber-substituted conditionally replicating adenovirus type 5 (Ad5) F35 vector on human bladder cancer cell lines such as 253J, 5637, KK-47, T24, TCCSUP, and UMUC-3 cells. Materials and Methods: Ad5F35 and Ad5 conditionally replicating adenovirus vectors containing the E1..Does Suspicion of Prostate Cancer on Integrated T2 and Diffusion-weighted MRI Predict More Adverse Pathology on Radical Prostatectomy?
Urology
Feb 2013
Does Suspicion of Prostate Cancer on Integrated T2 and Diffusion-weighted MRI Predict More Adverse Pathology on Radical Prostatectomy?
Objective: To determine whether suspicion for tumor on prostate MRI incorporating T2-weighted imaging (T2-WI) and diffusion-weighted imaging (DWI) predicts more adverse pathology on radical prostatectomy (RP). Methods: From 2007 to 2009, 154 patients underwent 1.5 Tesla pelvic-phased-array magnetic resonance imaging..Is an Initial Saturation Prostate Biopsy Scheme Better than an Extended Scheme for Detection of Prostate Cancer? A Systematic Review and Meta-analysis
European Urology
Feb 2013
Is an Initial Saturation Prostate Biopsy Scheme Better than an Extended Scheme for Detection of Prostate Cancer? A Systematic Review and Meta-analysis
Context: The optimal initial prostate biopsy core number is still an issue with many unanswered questions and significant controversy. Objective: To compare diagnostic values of initial saturation prostate biopsy scheme and extended scheme with respect to prostate-specific antigen (PSA) levels, prostate volume (PV),..Potential Consequences of Low Biopsy Core Number in Selection of Patients With Prostate Cancer for Current Active Surveillance Protocols
Urology
Feb 2013
Potential Consequences of Low Biopsy Core Number in Selection of Patients With Prostate Cancer for Current Active Surveillance Protocols
Objective: To compare the performance of the Epstein criteria and the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria in the identification of patients eligible for active surveillance (AS) but treated with radical prostatectomy. Materials and Methods: We evaluated the baseline..Predictors of the use of orthotopic bladder reconstruction after radical cystectomy for bladder cancer: data from a pilot study of 1756 cases 2004–2011
BJU International
Feb 2013
Predictors of the use of orthotopic bladder reconstruction after radical cystectomy for bladder cancer: data from a pilot study of 1756 cases 2004–2011
What's known on the subject? and What does the study add? How often orthotopic reconstruction should be used after radical cystectomy is uncertain. Male sex, younger age, affluence, white ethnicity and treatment in specialist hospitals may be associated with more frequent use. More evidence about the level and likely..Quality of Life after Radical Radiotherapy for Prostate Cancer: Longitudinal Study from a Randomised Trial of External Beam Radiotherapy Alone or in Combination with High Dose Rate Brachytherapy
Clinical Oncology
Feb 2013
Quality of Life after Radical Radiotherapy for Prostate Cancer: Longitudinal Study from a Randomised Trial of External Beam Radiotherapy Alone or in Combination with High Dose Rate Brachytherapy
Aim: To compare prospective, long-term quality of life in patients randomised to external beam radiotherapy (EBRT) alone or with a boost of high dose rate (HDR) brachytherapy. Materials and methods: In total, 216 patients participating in the UK randomised trial of EBRT ± HDR brachytherapy were included in this..Pathological response to neoadjuvant chemotherapy for muscle-invasive micropapillary bladder cancer
BJU International
Feb 2013
Pathological response to neoadjuvant chemotherapy for muscle-invasive micropapillary bladder cancer
What's known on the subject? and What does the study add? Micropapillary bladder cancer is a high grade variant with poor prognosis. There is no consensus about patients with micropapillary bladder cancer receiving neoadjuvant chemotherapy, but many suggest that radical cystectomy should not be delayed. Data from this..Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk
Clinical Oncology
Feb 2013
Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk
The clinical applications of stereotactic body radiotherapy or stereotactic ablative radiotherapy (SABR) for the treatment of primary and metastatic tumours of different organ sites have been expanding rapidly in the recent decade. SABR requires advanced technology in radiotherapy planning and image guidance to deliver..Merkel cell carcinoma from 2008 to 2012: Reaching a new level of understanding
Cancer Treatment Reviews
Feb 2013
Merkel cell carcinoma from 2008 to 2012: Reaching a new level of understanding
Merkel cell carcinoma (MCC) is a rare primary cutaneous carcinoma of the skin who has high aggressiveness, high risk of locoregional and distant spread, a mortality rate considerably higher than that of cutaneous melanoma and a poor survival. Its incidence has increased during the past twenty years. The studies..Developing a theoretical framework to illustrate associations among patient satisfaction, body image and quality of life for women undergoing breast reconstruction
Cancer Treatment Reviews
Feb 2013
Developing a theoretical framework to illustrate associations among patient satisfaction, body image and quality of life for women undergoing breast reconstruction
Within the field of breast reconstruction there is increasing focus on patient-reported outcomes related to satisfaction, body image, and quality of life. These outcomes are deemed highly relevant because the primary goal of breast reconstruction is to recreate the appearance of a breast (or breasts) that is satisfying..Targeted therapy in metastatic colorectal cancer – An example of personalised medicine in action
Cancer Treatment Reviews
Feb 2013
Targeted therapy in metastatic colorectal cancer – An example of personalised medicine in action
In metastatic colorectal cancer (mCRC), an improved understanding of the underlying pathology and molecular biology has successfully merged with advances in diagnostic techniques and local/systemic therapies as well as improvements in the functioning of multidisciplinary teams, to enable tailored treatment regimens and..A national study of the provision of oncology sperm banking services among Canadian fertility clinics
European Journal of Cancer Care
Feb 2013
A national study of the provision of oncology sperm banking services among Canadian fertility clinics
The purpose of this study was to survey the current state of oncology sperm banking services provided by fertility clinics across Canada. A total of 78 Canadian fertility facilities were invited to complete a questionnaire related to the availability, accessibility, affordability and utilisation of sperm banking..Safety and efficacy of paclitaxel liposome for elderly patients with advanced non-small cell lung cancer: A multi-center prospective study
Thoracic Cancer
Feb 2013
Safety and efficacy of paclitaxel liposome for elderly patients with advanced non-small cell lung cancer: A multi-center prospective study
Background: Lung cancer in elderly patients poses an increasingly challenge for oncologists. The optimal treatment needs to be explored. The purpose of this study was to evaluate the safety and efficacy of the novel form of paclitaxel liposome for elderly patients with non-small cell lung cancer (NSCLC). Methods: This..Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients
Thoracic Cancer
Feb 2013
Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients
Background: An elastofibroma is a benign, soft-tissue tumor and is important in the differential diagnosis of thoracic wall masses. Here, patients with elastofibromas who underwent thoracic surgery were retrospectively reviewed to elucidate elastofibroma formation and to facilitate the differential diagnosis. Methods:..Influence of patient characteristics on survival following treatment with helical stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer
Thoracic Cancer
Feb 2013
Influence of patient characteristics on survival following treatment with helical stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer
Background: To determine the influence of patient and tumor characteristics on clinical outcomes in patients with early-stage non-small cell lung cancer (NSCLC) treated with helical intensity modulated stereotactic body radiotherapy (SBRT). Methods: From March 2005 to August 2010 a total of 62 patients with biopsy..A thoracic surgeon's perspective on the elastofibroma dorsi: A benign tumor of the deep infrascapular region
Thoracic Cancer
Feb 2013
A thoracic surgeon's perspective on the elastofibroma dorsi: A benign tumor of the deep infrascapular region
Background: Lung cancer in elderly patients poses an increasingly challenge for oncologists. The optimal treatment needs to be explored. The purpose of this study was to evaluate the safety and efficacy of the novel form of paclitaxel liposome for elderly patients with non-small cell lung cancer (NSCLC). Methods: This..nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice
Thoracic Cancer
Feb 2013
nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice
Background: Lung cancer is the leading cause of cancer death in both men and women worldwide. Tumor metastasis is an essential aspect of lung cancer progression and patient death. The nm23-H1 gene has been extensively investigated as a metastasis suppressor gene. Our previous studies have revealed: that a significant..Lung cancer incidence and mortality in China, 2008
Thoracic Cancer
Feb 2013
Lung cancer incidence and mortality in China, 2008
Background: To provide cancer statistics to health planners, researchers, and the public, we reported the incidence and mortality data of lung cancer in 2008 in Chinese registration areas by age, sex, and geographic area. Methods: In 2011, 56 population-based cancer registries reported the lung cancer incidence and..Incidence and mortality of breast cancer in China, 2008
Thoracic Cancer
Feb 2013
Incidence and mortality of breast cancer in China, 2008
Background: Female breast cancer incidence and mortality data for the duration of 2008, in China, retrieved from the National Central Cancer Registry, was analyzed. Methods: In 2008, there were 56 registries that submitted cancer registration data. Based on the criteria of data quality, a total of 41 registries' data..Subcutaneous panniculitis-like T-cell lymphoma in the pediatric age group: A lymphoma of low malignant potential
Pediatric Blood & Cancer
Feb 2013
Subcutaneous panniculitis-like T-cell lymphoma in the pediatric age group: A lymphoma of low malignant potential
Background: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare neoplasm of mature αβ cytotoxic T-cells. Most commonly occurring in young adults, few reports are described in children. A separate analysis of a significant cohort of pediatric patients has not previously been performed. Procedure: We..Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations
Pediatric Blood & Cancer
Feb 2013
Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations
Background: Familial hemophagocytic lymphohistiocytosis (FHL) is a rare primary immune disorder defined by mutations in the syntaxin binding protein 2 (STXBP2) alias MUNC18-2. Despite defective immunity and a hyper-inflammatory state, clinical findings such as neurological, gastrointestinal, and bleeding disorders are..Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Pediatric Blood & Cancer
Feb 2013
Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Background: Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study was to determine genes..The safety of cefepime and ceftazidime in pediatric oncology patients
Pediatric Blood & Cancer
Feb 2013
The safety of cefepime and ceftazidime in pediatric oncology patients
Background: Concern has been raised about possible increased mortality associated with the use of cefepime. There are limited data available on the pragmatic use of beta-lactam antibiotics, especially in children. Procedure: This retrospective study included 532 pediatric oncology patients. The outcomes of patients..Anthracycline induced cardiac toxicity in pediatric Ewing sarcoma: A longitudinal study
Pediatric Blood & Cancer
Feb 2013
Anthracycline induced cardiac toxicity in pediatric Ewing sarcoma: A longitudinal study
Background: Reports on incidence and factors associated with anthracycline cardiotoxicity in patients with Ewing sarcoma vary and few studies evaluate effect over time. Longitudinal trends in cardiac function and prognostic value of % decline in ejection fraction (EF) during therapy have not been previously described..A Two-Stage Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Associated with Development of Urinary Symptoms Following Radiotherapy for Prostate Cancer
Journal of Urology
Feb 2013
A Two-Stage Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Associated with Development of Urinary Symptoms Following Radiotherapy for Prostate Cancer
Purpose: To identify SNPs associated with change in American Urological Association Symptom Score (AUASS) following radiotherapy (RT) for prostate cancer. Materials and Methods: 723 patients treated with brachytherapy with or without external beam radiation therapy were assessed at baseline and annually after RT using..Long-term Prostate-specific Antigen Velocity in Improved Classification of Prostate Cancer Risk and Mortality
European Urology
Feb 2013
Long-term Prostate-specific Antigen Velocity in Improved Classification of Prostate Cancer Risk and Mortality
Background: It remains unclear whether adding long-term prostate-specific antigen velocity (PSAV) to baseline PSA values improves classification of prostate cancer (PCa) risk and mortality in the general population. Objective: To determine whether long-term PSAV improves classification of PCa risk and mortality in the..Circulating tumor cells in colorectal cancer patients
Cancer Treatment Reviews
Feb 2013
Circulating tumor cells in colorectal cancer patients
The availability of sensitive methods has allowed the detailed study of circulating tumor cells only recently. Evolving evidence support the prognostic and predictive role of these cells in patients affected by several solid tumors, including colorectal cancer. Ongoing studies are aimed at confirming that the molecular..Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: Pharmacokinetic considerations and clinical implications
Cancer Treatment Reviews
Feb 2013
Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: Pharmacokinetic considerations and clinical implications
Identification of the role of biological pathways in metastatic renal cell carcinoma (mRCC) has led to the development of targeted agents for its treatment, in particular those that inhibit the vascular endothelial growth factor pathway, and inhibitors of mammalian target of rapamycin (mTOR). mTOR is central to..Cancer screening in the United States, 2013
CA: A Cancer Journal for Clinicians
Feb 2013
Cancer screening in the United States, 2013
Each year the American Cancer Society (ACS) publishes a summary of its recommendations for early cancer detection, a report on data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, current ACS cancer screening guidelines are summarized, as are updated..Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q)
Cancer Genetics
Jan 2013
Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q)
The isolated deletion of chromosome 20q [del(20q)] has been observed in both de novo and therapy-related cases of myelodysplastic syndrome (MDS). The clinicopathologic features of de novo MDS with isolated del(20q) are well characterized. However, relatively little is known about therapy-related myeloid neoplasms..Rituximab Maintenance Therapy Until Progression After Rituximab and Chemotherapy Induction in Patients With Follicular Lymphoma
Clinical Lymphoma Myeloma and Leukemia
Jan 2013
Rituximab Maintenance Therapy Until Progression After Rituximab and Chemotherapy Induction in Patients With Follicular Lymphoma
Introduction The PRIMA (Primary Rituximab and Maintenance) study established 2 years of maintenance rituximab (MR) as a standard of care for follicular lymphoma (FL) patients who achieve an objective response after induction chemotherapy. A 17% improvement in progression-free survival (PFS) compared with those who did..Abducted by the illness: A qualitative study of traumatic stress in individuals with acute leukemia
Leukemia Research
Jan 2013
Abducted by the illness: A qualitative study of traumatic stress in individuals with acute leukemia
Symptoms of traumatic stress are common in acute leukemia. The goal of the present qualitative study was to understand this traumatic stress, as perceived by patients. Participants were 43 patients with acute leukemia in Toronto, Canada. Participants were asked in serial interviews about their experience of diagnosis..High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
Leukemia Research
Jan 2013
High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m2 q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-risk..Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
Leukemia Research
Jan 2013
Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
Background: Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and..Does CA125 binding to mesothelin impact the detection of malignant mesothelioma?
Lung Cancer
Jan 2013
Does CA125 binding to mesothelin impact the detection of malignant mesothelioma?
The biomarker mesothelin is a useful diagnostic tool in malignant mesothelioma (MM) patients. It has high specificity but a sensitivity of only 50%. As mesothelin binds CA125, and as CA125 is often elevated in MM, we asked whether this binding affected measurable mesothelin levels in a relevant clinical setting...Farletuzumab in lung cancer
Lung Cancer
Jan 2013
Farletuzumab in lung cancer
Folate is essential for proliferating cells and folate transport pathways and folate-dependent metabolic processes show promise as targets for anti-neoplastic therapy. Folate receptor α (FOLR1), a folate transporter, is an attractive target for anti-neoplastic therapy due to its high affinity for folate, restricted..Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients
Lung Cancer
Jan 2013
Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients
Lung adenocarcinoma is the most common type of primary lung cancer. The purpose of this study was to delineate gene expression patterns for survival prediction in lung adenocarcinoma. Gene expression profiles of 82 (discovery set) and 442 (validation set 1) lung adenocarcinoma tumor tissues were analyzed using a..Concurrent chemoradiotherapy for large-volume locally-advanced non-small cell lung cancer
Lung Cancer
Jan 2013
Concurrent chemoradiotherapy for large-volume locally-advanced non-small cell lung cancer
Purpose: Patients with large volume stage III non-small cell lung cancer (NSCLC) are often excluded from concurrent chemoradiotherapy (CRT) protocols due to fears about excessive toxicity and poor survival. Patients with N3 nodal disease may be excluded for the same reason. We have routinely accepted fit patients in..A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer
Cancer Genetics
Jan 2013
A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer
Since the identification of the TMPRSS2-ERG rearrangement as the most common fusion event in prostate cancer, various methods have been developed to detect this rearrangement and to study its prognostic significance. We report a novel four-color fluorescence in situ hybridization (FISH) assay that detects not only the..Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: Systematic review and meta-analysis of the literature
Lung Cancer
Jan 2013
Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: Systematic review and meta-analysis of the literature
Background: Not all patients with non-small cell lung carcinoma (NSCLC) have mediastinal lymph node involvement and development of less invasive methods for evaluating mediastinal lymph nodes is important. Sentinel node biopsy has been used for NSCLC since 1999 to decrease the need for mediastinal lymph node..Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer
Lung Cancer
Jan 2013
Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer
Lung cancer is sometimes difficult to differentiate from benign lung diseases expressing nodular shadow in imaging study. We assessed the diagnostic value of two commonly used tumor markers in distinguishing primary lung cancer from benign lung disease. The serum levels of carcinoembryonic antigen (CEA) and cytokeratin..Reliability of EGFR and KRAS mutation analysis on fine-needle aspiration washing in non-small cell lung cancer
Lung Cancer
Jan 2013
Reliability of EGFR and KRAS mutation analysis on fine-needle aspiration washing in non-small cell lung cancer
Introduction: Molecular profiling of advanced non-small cell lung cancer (NSCLC) has become essential for predicting customized medical treatment decision. In light of recent advances in non-invasive diagnostic procedures in NSCLC, we aimed to demonstrate the reliability of assessing molecular tests for epidermal..Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria
Leukemia Research
Jan 2013
Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria
Hairy cell leukemia (HCL) and hairy cell leukemia-variant (HCL-v) are rare diseases with overlapping clinico-pathological features. We performed flow cytometry analysis (FCM) of 213 cases (169 HCL, 35 HCL-v, 9 splenic marginal zone lymphoma (SMZL)), correlating results with available corresponding clinical and..Is immune escape via human leukocyte antigen expression clinically relevant in chronic lymphocytic leukemia? Focus on the controversies
Leukemia Research
Jan 2013
Is immune escape via human leukocyte antigen expression clinically relevant in chronic lymphocytic leukemia? Focus on the controversies
Changes in classical and non-classical human leukocyte antigen expression by tumor cells can play a critical role in the generation of tumor antigen-specific immune responses and can modulate the interactions of natural killer cells and T cell subpopulations with target cells. Recently, several studies have..p16INK4a deficiency promotes DNA hyper-replication and genetic instability in melanocytes
Pigment Cell & Melanoma Research
Jan 2013
p16INK4a deficiency promotes DNA hyper-replication and genetic instability in melanocytes
Activated oncogenes restrict cell proliferation and transformation by triggering a DNA damage-dependent senescence checkpoint in response to DNA hyper-replication. Here, we show that loss of the p16INK4a cyclin-dependent kinase inhibitor and melanoma tumour suppressor facilitates a DNA damage response after a..Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria
Cancer Letters
Jan 2013
Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria
Failure of anti-cancer therapy in colorectal cancer (CRC) cells involves resistance to death mechanisms. We investigated grape seed extract (GSE) ability to target CRC cells and delineated the mechanisms involved in GSE-induced CRC cell death. GSE selectively induced apoptotic death in human CRC cells; efficacy..Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
Cancer Letters
Jan 2013
Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
Phytochemicals are well known to have cancer chemopreventive effects by induction of phase II detoxification enzymes including quinone reductase (NQO-1) and glutathione-S-transferases. These detoxification enzymes are commonly regulated by nuclear factor-E2 (Nrf2), which is a representative antioxidant and..Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma
Cancer Letters
Jan 2013
Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma
Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor prognosis. Current standard treatment includes chemotherapy using DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. However, GBM patients exhibit various levels of the elevated expression of..Perioperative Complications and Mortality After Radical Cystectomy When Using a Standardized Reporting Methodology
Clinical Genitourinary Cancer
Jan 2013
Perioperative Complications and Mortality After Radical Cystectomy When Using a Standardized Reporting Methodology
Purpose: To evaluate, by using a standardized reporting methodology, the perioperative complications and mortality in patients who underwent radical cystectomy. Materials and Methods: We retrospectively reviewed all data of 404 consecutive patients who underwent radical cystectomy from 1995 to 2009 for nonmetastatic..Role of Conventional Chemosensitivity Test and Tissue Biomarker Expression in Predicting Response to Treatment of Peritoneal Carcinomatosis From Colon Cancer
Clinical Colorectal Cancer
Jan 2013
Role of Conventional Chemosensitivity Test and Tissue Biomarker Expression in Predicting Response to Treatment of Peritoneal Carcinomatosis From Colon Cancer
Background: 5-Fluorouracil- or oxaliplatin-based regimens are the treatments of choice in patients with PC from colon cancer. There are currently no useful preclinical evaluations to guide the decision-making process for tailored therapy. The aim of the present study was to compare the advantages and limits of a..Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy
BJU International
Jan 2013
Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy
What's known on the subject? and What does the study add? It is known that a prostate cancer gene 3 (PCA3) urine assay is superior to serum PSA level or PSA-related indices for predicting a positive biopsy result in European and US men. This is the first report on PCA3 in a large cohort of Japanese men. The diagnostic..Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to standardize protocols?
BJU International
Jan 2013
Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to standardize protocols?
What's known on the subject? and What does the study add?The topic of radiation safety has been hotly debated not only in the mainstream media, but also in the urological literature. Radiation exposure has been examined in urological diseases such as testicular cancer and urinary stone disease, with resultant..Pooled Analysis of Phase II Trials Evaluating Weekly or Conventional Cisplatin as First-Line Therapy for Advanced Urothelial Carcinoma
Clinical Genitourinary Cancer
Jan 2013
Pooled Analysis of Phase II Trials Evaluating Weekly or Conventional Cisplatin as First-Line Therapy for Advanced Urothelial Carcinoma
Background: Weekly gemcitabine with GC every 3-4 weeks is considered conventional first-line chemotherapy for advanced urothelial carcinoma (UC). Weekly split-dose cisplatin with wGC might be less toxic and have similar activity, but has not been compared with GC. We pooled published phase II trials of GC and wGC to..Cancer statistics, 2013
CA: A Cancer Journal for Clinicians
Jan 2013
Cancer statistics, 2013
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and..Consumption of deep-fried foods and risk of prostate cancer
The Prostate
Jan 2013
Consumption of deep-fried foods and risk of prostate cancer
Background: Evidence suggests that high-heat cooking methods may increase the risk of prostate cancer (PCa). The addition of oil/fat, as in deep-frying, may be of particular concern, and has not specifically been investigated in relation to PCa. Potential mechanisms include the formation of potentially carcinogenic..Phase II open label, multi-center clinical trial of modulation of intermediate endpoint biomarkers by 1α-hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
The Prostate
Jan 2013
Phase II open label, multi-center clinical trial of modulation of intermediate endpoint biomarkers by 1α-hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
Background: Prostate cancer is the most common malignancy and second leading cause of cancer related deaths in American men supporting the study of prostate cancer chemoprevention. Major risk factors for this disease have been associated with low serum levels of vitamin D. Here, we evaluate the biologic activity of a..Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model
The Prostate
Jan 2013
Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model
Background: Bone metastasis is a serious problem for individuals with prostate cancer, and the effects of the anticancer drug docetaxel (DTX) are insufficient. We therefore examined the therapeutic potential of magnetic cationic liposomes (MCL) in a novel rat model that allows the evaluation of tumor immunity. The..A novel canine model for prostate cancer
The Prostate
Jan 2013
A novel canine model for prostate cancer
Background: No existing animal model fully recapitulates all features of human prostate cancer. The dog is the only large mammal, besides humans, that commonly develops spontaneous prostate cancer. Canine prostate cancer features many similarities with its human counterpart. We sought to develop a canine model of..High-grade prostate cancer and biochemical recurrence after radical prostatectomy among men using 5α-reductase inhibitors and alpha-blockers
The Prostate
Jan 2013
High-grade prostate cancer and biochemical recurrence after radical prostatectomy among men using 5α-reductase inhibitors and alpha-blockers
Background: Two clinical trials have shown that users of 5α-reductase inhibitors finasteride and dutasteride (5-ARIs) have reduced overall prostate cancer risk, while the proportion of high-grade tumors is increased. We studied tumor characteristics, risk of biochemical recurrence and mortality after radical..Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases
The Prostate
Jan 2013
Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases
Background: Approximately 90% of patients who die of Prostate Cancer (PCa) have bone metastases, which promote a spectrum of osteoblastic, osteolytic or mixed bone responses. Numerous secreted proteins have been reported to promote osteoblastic or osteolytic bone responses. We determined whether previously identified..Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell
The Prostate
Jan 2013
Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell
Background: The role of CXCL1 in prostate cancer (PCa) progression has been poorly investigated. A limitation of previous studies is linked to the use of human PCa cell lines PC3 and DU145, producing CXCL8 at levels strongly exceeding CXCL1 levels. Moreover, in mouse models the sharing of CXCR2 receptor by both ligands..The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
The Prostate
Jan 2013
The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
Background: The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined. Methods: We assayed for the presence of the G84E mutation in 3,515 prostate cancer..Place of Residence and Primary Treatment of Prostate Cancer: Examining Trends in Rural and Nonrural Areas in Wisconsin
Urology
Jan 2013
Place of Residence and Primary Treatment of Prostate Cancer: Examining Trends in Rural and Nonrural Areas in Wisconsin
Objective: To determine whether rural residents were at a disadvantage compared with urban residents with regard to the receipt of curative therapy for prostate cancer. Materials and Methods: Using the Breast and Prostate Cancer Data Quality and Patterns of Care Study II, patients with prostate cancer who were..Differing risk of cancer death among patients with lymph node metastasis after radical prostatectomy and pelvic lymph node dissection: identification of risk categories according to number of positive nodes and Gleason score
BJU International
Jan 2013
Differing risk of cancer death among patients with lymph node metastasis after radical prostatectomy and pelvic lymph node dissection: identification of risk categories according to number of positive nodes and Gleason score
What's known on the subject? and What does the study add? Lymph node (LN) status is one of the most important prognostic variables in patients undergoing radical prostatectomy, but not all patients with node-positive PCa are at the same risk of recurrence and cancer-specific death. In this study we evaluated the role..Pathological and biochemical outcomes after radical prostatectomy in men with low-risk prostate cancer meeting the Prostate Cancer International: Active Surveillance criteria
BJU International
Jan 2013
Pathological and biochemical outcomes after radical prostatectomy in men with low-risk prostate cancer meeting the Prostate Cancer International: Active Surveillance criteria
What's known on the subject? and What does the study add? Active surveillance has been widely accepted as a treatment tool for low-risk prostate cancer, and use of the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria can select smaller and less aggressive tumours in low-risk disease. The..Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer?
BJU International
Jan 2013
Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer?
What's known on the subject? and What does the study add? Urothelial carcinoma of the bladder (UCB) is more prevalent in men than women; however, in women the tumour stage is generally more advanced at the time of the diagnosis and the prognosis is worse. Possible explanations include anatomical, genetic and..Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort
BJU International
Jan 2013
Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort
What's known on the subject? and What does the study add? Family history (FH) is a major risk factor for the development of prostate cancer. The search for genetic variants has led to genome-wide association studies (GWAS), which have so far reported 47 susceptibility loci that predispose men to prostate cancer...Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer
BJU International
Jan 2013
Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer
What's known on the subject? and What does the study add? The use of MRI for prostate cancer diagnosis and staging is increasing. Indications for prostate MRI are not defined and many clinicians are unsure of how best to use MRI to aid clinical decisions. This evidence-based medicine article addresses the clinical..Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population
BJU International
Jan 2013
Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population
What's known on the subject? and What does the study add? The use of a single, elevated PSA level to screen for prostate cancer is controversial given its reported low specificity and the questionable benefits of PSA screening on prostate cancer mortality. Current guidelines in the USA recommend against screening using..Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover
Cancer Letters
Jan 2013
Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover
Store-operated Ca2+ entry (SOCE) is a main Ca2+ influx pathway controlling the intracellular Ca2+ concentration in normal hepatocytes and hepatocellular carcinoma (HCC) cells. Ca2+ influx has been demonstrated to be involved in liver oncogenesis. Stromal interacting molecule (STIM) 1 acts as a sensor for the level of..Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma
Cancer Letters
Jan 2013
Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma
Aldehyde dehydrogenase 1 (ALDH1) activity has now been employed successfully as a cancer stem cells (CSCs) marker in various tumors. We wanted to investigate whether ALDH1 can be used as a putative CSCs marker and a powerful prognostic factor in nasopharyngeal carcinoma (NPC). Here, we isolated ALDH1-positive cells..Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis
Cancer Letters
Jan 2013
Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis
The anti-tumor activity, metronomic chemotherapy sensitization potential and metastatic effects of the endogenous angiogenesis inhibitors thrombospondin-1 and PEDF were investigated in KM12 colon adenocarcinoma xenografts. Thrombospondin-1 and PEDF decreased KM12 tumor microvessel density, increased macrophage..The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
Cancer Letters
Jan 2013
The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in..Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer
Cancer Letters
Jan 2013
Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer
We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was..Targeting triple negative breast cancer: Is p53 the answer?
Cancer Treatment Reviews
Jan 2013
Targeting triple negative breast cancer: Is p53 the answer?
Triple negative breast cancers, which are defined by lack of expression of estrogen, progesterone, or HER2 receptors, represent approximately 15% of all breast cancers, although they account for a much higher proportional of breast cancer mortality. This is due both to their innate aggressive biological..A contemporary update on rates and management of toxicities of targeted therapies for metastatic renal cell carcinoma
Cancer Treatment Reviews
Jan 2013
A contemporary update on rates and management of toxicities of targeted therapies for metastatic renal cell carcinoma
Background: To provide an updated review of adverse events associated with sunitinib, pazopanib, bevacizumab, temsirolimus, axitinib, everolimus and sorafenib and their management. Materials and methods: We performed a PubMed and Cochrane-based review of side effects associated with the seven agents including product..Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor
Clinical Genitourinary Cancer
Jan 2013
Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor
Background: Our objective was to perform a long-term evaluation of conservative surgical treatment of Leydig cell tumors. Patients and Methods: A multicenter retrospective clinical study was performed at 6 European centers. Case files of all patients diagnosed with Leydig cell tumor and treated with conservative..Comparison of Dietary and Lifestyle Habits Among Stage III and Metastatic Colorectal Cancer Patients: Findings from CALGB 89803 and CALGB 80405
Clinical Colorectal Cancer
Jan 2013
Comparison of Dietary and Lifestyle Habits Among Stage III and Metastatic Colorectal Cancer Patients: Findings from CALGB 89803 and CALGB 80405
Background: Cancer patients often pursue lifestyle and dietary changes with the aim to improve outcomes. Using data from 2 large National Cancer Institute-sponsored clinical trials, we report on the dietary and lifestyle practices of patients receiving therapy for stage III colon or metastatic colorectal cancer...Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression
Pigment Cell & Melanoma Research
Jan 2013
Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression
The best-established function of the melanoma-suppressor p16 is mediation of cell senescence, a permanent arrest following cell proliferation or certain stresses. The importance of p16 in melanoma suggests indolence of the other major senescence pathway through p53. Little or no p53 is expressed in senescent normal..Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells
Clinical Colorectal Cancer
Jan 2013
Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells
Background: Colorectal cancer is the second leading cause of cancer-related mortality and frequently presents with locally advanced or metastatic disease. Adenovirus (Ad) vectors are important gene delivery agents because they offer efficient and broad tissue transduceability. However, their ability to penetrate..Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells
Pigment Cell & Melanoma Research
Jan 2013
Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells
Here, we explored the effects of the novel class II-specific histone deacetylase inhibitors (HDACis) MC1568 and MC1575 on interleukin-8 (IL-8) expression and cell proliferation in cutaneous melanoma cell line GR-M and uveal melanoma cell line OCM-3 upon stimulation with phorbol 12-myristate 13-acetate (PMA). We found..RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics
Pigment Cell & Melanoma Research
Jan 2013
RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics
Rho family GTPases regulate diverse processes in human melanoma ranging from tumor formation to metastasis and chemoresistance. In this study, a combination of in vitro and in vivo approaches was utilized to determine whether RHOJ, a CDC42 homologue that regulates melanoma chemoresistance, also controls melanoma..Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Leukemia Research
Nov 2012
Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Flow cytometry based minimal residual disease (MRD) was evaluated for outcome prediction in childhood acute myeloid leukemia (AML). The median levels of MRD in relapsed and nonrelapsed patients were different after the first induction (0.64% vs. 0.18%, P=0.030). A cutoff level of ≥0.25% after the first course of..Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Leukemia Research
Nov 2012
Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Flow cytometry based minimal residual disease (MRD) was evaluated for outcome prediction in childhood acute myeloid leukemia (AML). The median levels of MRD in relapsed and nonrelapsed patients were different after the first induction (0.64% vs. 0.18%, P=0.030). A cutoff level of ≥0.25% after the first course of..Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Leukemia Research
Nov 2012
Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Spurred by previous observations we assessed the relationship between offspring birth weight and parental leukaemia risk in a register-based investigation including 2.4 million parents of 2 million Danish children. Regardless of analytical approach, offspring birth weight was not associated with parental risk of..Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
Leukemia Research
Nov 2012
Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
The main objective of this systematic review is to quantify and to summarize all studies that have included health-related quality of life (HRQOL) or, any other type of patient-reported outcomes (PROs), in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Nine papers were..Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Leukemia Research
Nov 2012
Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Spurred by previous observations we assessed the relationship between offspring birth weight and parental leukaemia risk in a register-based investigation including 2.4 million parents of 2 million Danish children. Regardless of analytical approach, offspring birth weight was not associated with parental risk of..Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
Leukemia Research
Nov 2012
Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
The main objective of this systematic review is to quantify and to summarize all studies that have included health-related quality of life (HRQOL) or, any other type of patient-reported outcomes (PROs), in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Nine papers were..Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
Leukemia Research
Nov 2012
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms, in which a stem cell lesion induces an autonomous proliferative advantage. In addition to the JAK2V617 mutation several other mutations have been described. Recently chronic inflammation has been proposed as a..Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
Leukemia Research
Nov 2012
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms, in which a stem cell lesion induces an autonomous proliferative advantage. In addition to the JAK2V617 mutation several other mutations have been described. Recently chronic inflammation has been proposed as a..Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Leukemia Research
Nov 2012
Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Multiple myeloma (MM) is an incurable plasma cell malignancy, which causes a significant morbidity due to organ damage and bone tissue destruction. In recent years, novel drugs have become available for MM therapy thanks to a more deepened knowledge of this disease's pathogenesis. The perspective of employing targeted..Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Leukemia Research
Nov 2012
Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Multiple myeloma (MM) is an incurable plasma cell malignancy, which causes a significant morbidity due to organ damage and bone tissue destruction. In recent years, novel drugs have become available for MM therapy thanks to a more deepened knowledge of this disease's pathogenesis. The perspective of employing targeted..Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
Leukemia Research
Nov 2012
Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
In vivo effects of the DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) upon the epigenome of acute myeloid leukemia (AML) patients are scarcely studied in primary blasts. Here, we sequentially assessed DNA methylation and transcriptome changes in myeloblasts of DAC-treated AML patients. DNA methylation changes..Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
Leukemia Research
Nov 2012
Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
In vivo effects of the DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) upon the epigenome of acute myeloid leukemia (AML) patients are scarcely studied in primary blasts. Here, we sequentially assessed DNA methylation and transcriptome changes in myeloblasts of DAC-treated AML patients. DNA methylation changes..Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes
Leukemia Research
Nov 2012
Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes
Dendritic cells (DC) are antigen-presenting cells that play a pivotal role in coordinating functions of the immune system. Previous studies suggest that bone marrow (BM) failure in myelodysplastic syndromes (MDS) may be in part immune-mediated, and that the high propensity for relapse may reflect decreased immune..Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment
Leukemia Research
Nov 2012
Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment
Peripheral T-cell lymphomas (PTCL) are a diverse group of rare non-Hodgkin lymphomas (NHL) that carry a poor prognosis and are in need of effective therapies. Alisertib (MLN8237) an investigational agent that inhibits Aurora A Ser/Thr kinase has shown activity in PTCL patients. Here we demonstrate that aurora A and B..Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes
Leukemia Research
Nov 2012
Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes
We have previously demonstrated that two prognostic features of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), mutant NRAS and over-expressing BCL-2, cooperate physically and functionally in vivo. Screening of MDS patient bone marrow (BM) identified NRAS:BCL-2 co-localization in 64% cases,..Inducing Cell Proliferation Inhibition, Apoptosis, and Motility Reduction by Silencing Long Noncoding Ribonucleic Acid Metastasis-associated Lung Adenocarcinoma Transcript 1 in Urothelial Carcinoma of the Bladder
Urology
Nov 2012
Inducing Cell Proliferation Inhibition, Apoptosis, and Motility Reduction by Silencing Long Noncoding Ribonucleic Acid Metastasis-associated Lung Adenocarcinoma Transcript 1 in Urothelial Carcinoma of the Bladder
Objective: To study the expression patterns of long noncoding ribonucleic acid (RNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the cell proliferation inhibition, apoptosis, and motility changes induced by silencing MALAT1 in urothelial carcinoma of the bladder. Materials and Methods: The..Probability of Downsizing Primary Tumors of Renal Cell Carcinoma by Targeted Therapies Is Related to Size at Presentation
Urology
Nov 2012
Probability of Downsizing Primary Tumors of Renal Cell Carcinoma by Targeted Therapies Is Related to Size at Presentation
Objective: To evaluate the probability of downsizing primary renal tumors by targeted therapy in correlation to size. Methods: A literature search was conducted and our own data were pooled with data of retrospective series and prospective trials in which patients were treated with tyrosine kinase inhibitors (TKIs) and..Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer
The Prostate
Sep 2012
Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer
Background: Dystroglycan is a ubiquitously expressed cell adhesion molecule frequently found to be altered or reduced in adenocarcinomas, however the mechanisms or consequences of dystroglycan loss have not been studied extensively. Methods: We examined the consequence of overexpression or RNAi depletion of..Functional p53 determines docetaxel sensitivity in prostate cancer cells
The Prostate
Sep 2012
Functional p53 determines docetaxel sensitivity in prostate cancer cells
Background: Docetaxel is the first line treatment for castration resistant prostate cancer (CRPC). However, docetaxel resistance rapidly develops. Identifying the critical mechanisms giving rise to docetaxel resistance is the major challenge in advanced prostate cancer. Methods: The effects of docetaxel on human DU145,..Gene expression analysis in prostate cancer: The importance of the endogenous control
The Prostate
Sep 2012
Gene expression analysis in prostate cancer: The importance of the endogenous control
Background: Aberrant gene expression is a hallmark of cancer. Quantitative reverse-transcription PCR (qRT-PCR) is the gold-standard for quantifying gene expression, and commonly employs a house-keeping gene (HKG) as an endogenous control to normalize results; the choice of which is critical for accurate data..Anterior gradient 2 (AGR2): Blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype
The Prostate
Aug 2012
Anterior gradient 2 (AGR2): Blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype
Background: Anterior gradient 2 (AGR2) is associated with metastatic progression in prostate cancer cells as well as other normal and malignant tissues. We investigated AGR2 expression in patients with metastatic prostate cancer. Methods: Blood was collected from 44 patients with metastatic prostate cancer separated..Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer
The Prostate
Aug 2012
Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer
Background: Recent studies show that microRNAs (miRNAs), small non-coding RNAs that negatively regulate gene expression, may have potential for monitoring cancer status. We investigated circulating miRNAs in prostate cancer that may be associated with the progression of hormone-sensitive primary tumors to metastatic..Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer
The Prostate
Aug 2012
Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer
Purpose: This study was conducted to investigate the effect of Se supplementation on prostate cancer incidence in men at high risk for prostate cancer. Methods: A Phase 3 randomized, double-blind, placebo-controlled clinical trial was conducted in 699 men at high risk for prostate cancer (prostate specific antigen..Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa)
The Prostate
Aug 2012
Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa)
Background: Proton-coupled oligopeptide transporters (POTs) serve as integral membrane protein for the cellular uptake of di/tripeptide. Prostate has a large requirement of nutriment for its function to produce and secrete prostatic fluid. Besides, prostate suffered from limited therapy effect of drug treatment. Thus..Human papillomavirus and Epstein Barr virus in prostate cancer: Koilocytes indicate potential oncogenic influences of human papillomavirus in prostate cancer
The Prostate
Jul 2012
Human papillomavirus and Epstein Barr virus in prostate cancer: Koilocytes indicate potential oncogenic influences of human papillomavirus in prostate cancer
Introduction: The purpose of this study is to determine if high risk human papillomaviruses (HPV) and Epstein Barr virus (EBV) are both present in the same prostate cancer specimens. Methods: We used a range of analytical techniques including in situ polymerase chain reaction (IS-PCR) and standard liquid PCR followed..Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy
The Prostate
Jul 2012
Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy
Background: Prostate health index (phi) and prostate cancer antigen 3 (PCA3) have been recently proposed as novel biomarkers for prostate cancer (PCa). We assessed the diagnostic performance of these biomarkers, alone or in combination, in men undergoing first prostate biopsy for suspicion of PCa. Methods: One hundred..Urine TMPRSS2:ERG fusion transcript integrated with PCA3 score, genotyping, and biological features are correlated to the results of prostatic biopsies in men at risk of prostate cancer
The Prostate
Jul 2012
Urine TMPRSS2:ERG fusion transcript integrated with PCA3 score, genotyping, and biological features are correlated to the results of prostatic biopsies in men at risk of prostate cancer
Background: Detection of fusion gene TMPRSS2:ERG transcripts in urine have been recently described in order to refine urine-based detection of prostate cancer (PCa), but data its clinical impact remain scarce. We aimed at investigating the correlation of TMPRSS2:ERG, prostate cancer antigen 3 (PCA3), prostate specific..Use of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy
The Prostate
Jul 2012
Use of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy
Background: Experimental evidence suggests a role for the β2-adrenergic receptor pathway in prostate cancer (PCa). We have investigated the association of β-blocker use with PCa incidence and survival in a Norwegian cohort. Methods: Data from the Oslo II study in 2000 (n = 6515) were linked with information from the..Prediction of post-remission survival in acute myeloid leukaemia: a post-hoc analysis of the AML96 trial
The Lancet Oncology
Dec 2011
Prediction of post-remission survival in acute myeloid leukaemia: a post-hoc analysis of the AML96 trial
Background: The optimum post-remission treatment (PRT) in acute myeloid leukaemia (AML) is still a matter of debate. Consolidation treatments include chemotherapy with high-dose cytarabine, or allogeneic or autologous haemopoietic stem cell transplantation (HSCT). In a post-hoc analysis of the AML96 trial..Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: a phase 2, randomised, double-blind, placebo-controlled study
The Lancet Oncology
Dec 2011
Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: a phase 2, randomised, double-blind, placebo-controlled study
Background: Targeting of VEGF is a potential therapeutic option in patients with malignant ovarian ascites. We present the final results of a multicentre study of the efficacy and safety of aflibercept, a potent inhibitor of both VEGF and placental growth factor, in the treatment of malignant ascites. Methods: In this..Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study
The Lancet Oncology
Dec 2011
Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study
Background: Combination chemotherapy with gemcitabine and a platinum-based agent is regarded as a standard treatment for patients with advanced biliary-tract cancer. Results of phase 2 trials of single-agent erlotinib in biliary-tract cancer and of gemcitabine plus erlotinib in pancreatic cancer have shown modest..Therapy-related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy
European Journal of Haematology
Nov 2011
Therapy-related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy
Therapy-related acute promyelocytic leukemia (t-APL) is a well-recognized form of APL for which the underlying etiology has been well characterized. The pathogenesis of de novo (dn-APL) remains unknown; but epidemiologic studies have consistently identified increased body mass index (BMI), younger age, and ethnicity as..Meningiomas in children and adolescents: a meta-analysis of individual patient data
The Lancet Oncology
Nov 2011
Meningiomas in children and adolescents: a meta-analysis of individual patient data
Background: The epidemiological, prognostic, and therapeutic features of child and adolescent meningioma are poorly defined. Clinical knowledge has been drawn from small case series and extrapolation from adult studies. This study was done to pool and analyse the clinical evidence on child and adolescent meningioma...How to manage vaccinations in children with cancer
Pediatric Blood & Cancer
Sep 2011
How to manage vaccinations in children with cancer
The optimal use of routine childhood immunizations in children with malignancy is still a matter of debate. Despite their higher risk of contracting vaccine preventable diseases and of suffering important complications, there is little understanding of the magnitude of the possible benefit of administering active..Targeting the Tumor Microenvironment: Focus on Angiogenesis
Journal of Oncology
Aug 2011
Targeting the Tumor Microenvironment: Focus on Angiogenesis
Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment. One key compartment of the microenvironment is the vascular niche. The role of angiogenesis in solid tumors but also in..Circulating and disseminated tumor cells in the management of advanced prostate cancer.
Advances in Urology
Aug 2011
Circulating and disseminated tumor cells in the management of advanced prostate cancer.
Management of prostate cancer is recognized as one of the most important medical problems. Latest findings concerning the role of circulating (CTC) and disseminated tumor cells (DTC) have provided new insights into the biology of metastasis with important implications for the clinical management of prostate cancer..miRNAs and Melanoma: How Are They Connected?
Dermatology Research and Practice
Aug 2011
miRNAs and Melanoma: How Are They Connected?
miRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation. It is predicted that over 30% of RNAs are regulated by miRNAs. Therefore these molecules are considered essential in the processing of many biological responses, such..
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