Neonatal/Perinatal Medicine Medical Journal Abstracts
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Differences in Birthweight Curves Between Newborns of Immigrant Mothers vs. Infants Born in Their Corresponding Native Countries: Systematic Overview
Paediatric and Perinatal Epidemiology
Feb 2013
Differences in Birthweight Curves Between Newborns of Immigrant Mothers vs. Infants Born in Their Corresponding Native Countries: Systematic Overview
Background: Newborn weight may vary between ethnic groups, but it is not known if birthweight differences exist between term babies born to immigrant mothers compared with those born in their corresponding native countries. Methods: We completed a systematic review of all birthweight curves published between 1980 and..A Test of Agreement of Customised Birthweight Models
Paediatric and Perinatal Epidemiology
Feb 2013
A Test of Agreement of Customised Birthweight Models
Background: The objective of this study was to determine whether the physiological effects on birthweight as described by customised birthweight models (CBMs) from various populations and locations are consistent when applied to a single sample. Methods: The predicted birthweight was calculated for 52 826..Risk Factors for Acute Respiratory Morbidity in Moderately Preterm Infants
Paediatric and Perinatal Epidemiology
Feb 2013
Risk Factors for Acute Respiratory Morbidity in Moderately Preterm Infants
Background: Infants born preterm account for a substantial part of neonatal morbidity, with acute respiratory disorders being a dominating clinical problem. Whereas focus in recent studies has been on extremely and very preterm infants, less is known about contemporary rates and risk factors for acute respiratory..In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma
Prenatal Diagnosis
Jan 2013
In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma
Objectives: We aimed to demonstrate local thrombin generation by fetal membranes, as well as its ability to generate fibrin from fibrinogen concentrate. Furthermore, we aimed to investigate the efficacy of collagen plugs, soaked with plasma and fibrinogen, to seal iatrogenic fetal membrane defects. Methods: Thrombin..The effect of hereditary versus acquired thrombophilia on triple test Down's syndrome screening
Prenatal Diagnosis
Jan 2013
The effect of hereditary versus acquired thrombophilia on triple test Down's syndrome screening
Objective: To compare the profile of mid gestation triple test serum markers between a cohort of women with history of pregnancy complications with hereditary versus acquired thrombophilia. All were treated with low molecular weight heparin (LMWH) prior to 12 weeks' gestation. Methods: A retrospective analysis of..Have the boundaries of the ‘grey zone’ of perinatal resuscitation changed for extremely preterm infants over 20 years?
Acta Paediatrica
Jan 2013
Have the boundaries of the ‘grey zone’ of perinatal resuscitation changed for extremely preterm infants over 20 years?
Aim: To determine the boundaries of the grey zone of discretionary resuscitation over the past 20 years. Background: As the likelihood of survival improves over time, the BW- and GA-specific boundaries of discretionary nonresuscitation should fall. Hypothesis: Between 1988 and 2008 reductions in BW- and GA-specific..Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo-oxygenase inhibitor naïve population
Acta Paediatrica
Jan 2013
Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo-oxygenase inhibitor naïve population
Aims: To examine the relationship between early duct diameter and patent ductus arteriosus (PDA) symptoms. Methods: A retrospective study of infants <29 weeks of gestation with early colour Doppler assessment of PDA diameter, in whom PDA was managed conservatively, without cyclo-oxygenase inhibitor (COI) treatment...Impact of nursing care on temperature environment in preterm newborns nursed in closed convective incubators
Acta Paediatrica
Jan 2013
Impact of nursing care on temperature environment in preterm newborns nursed in closed convective incubators
Aims: Very-low-birth-weight (VLBW) neonates require regular nursing procedures with frequent opening of the incubator resulting in a decrease in incubator air temperature. This study was designed to assess changes in the thermal status of VLBW neonates according to the type of nursing care and incubator openings...Increased autophagy in the placental territory of selective intrauterine growth-restricted monochorionic twins
Prenatal Diagnosis
Jan 2013
Increased autophagy in the placental territory of selective intrauterine growth-restricted monochorionic twins
Subject: This study investigates the placental autophagic activity in growth-restricted fetuses in the monochorionic (MC) twin model. Patients and methods: Forty MC twins were prospectively enrolled in this study, including 21 with and 19 without selective intrauterine growth restriction (sIUGR), defined as birth..Atrial Tachyarrhythmias and the Cox-maze Procedure in Congenital Heart Disease
Congenital Heart Disease
Dec 2012
Atrial Tachyarrhythmias and the Cox-maze Procedure in Congenital Heart Disease
Introduction: Atrial tachyarrhythmias, particularly atrial flutter and fibrillation, are commonly associated with congenital heart disease and are a major cause of morbidity and mortality. The Cox-maze procedure, introduced by Dr. James Cox in 1987, is effective at controlling atrial fibrillation in structurally normal..Doppler Tissue Imaging Provides an Estimate of Pulmonary Arterial Pressure in Children with Pulmonary Hypertension Due to Congenital Intracardiac Shunts
Congenital Heart Disease
Dec 2012
Doppler Tissue Imaging Provides an Estimate of Pulmonary Arterial Pressure in Children with Pulmonary Hypertension Due to Congenital Intracardiac Shunts
Objective: The aim of this study is to determine the relationship between the cardiac catheterization findings and pulsed-wave (PW) Doppler and Doppler tissue imaging (DTI) in pulmonary arterial hypertension patients with congenital heart disease with intracardiac shunts. Design and Patients: The present study aims to..The American Heart Association's Recent Scientific Statement on Cardiac Critical Care: Implications for Pediatric Practice
Congenital Heart Disease
Dec 2012
The American Heart Association's Recent Scientific Statement on Cardiac Critical Care: Implications for Pediatric Practice
A writing group sponsored by the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the Council on Quality of Care and Outcomes Research of The American Heart Association has recently formulated a roadmap to meet the..Transesophageal Echocardiography Probe Insertion Failure in Infants Undergoing Cardiac Surgery
Congenital Heart Disease
Dec 2012
Transesophageal Echocardiography Probe Insertion Failure in Infants Undergoing Cardiac Surgery
Background: The use of intraoperative transesophageal echocardiography (iTEE) in neonates ≤4 kg has not been systematically described. We sought to describe the use of and determine risk factors for iTEE probe insertion failure in small infants. We also sought to develop an algorithm for predicting the likelihood of..Extremely low birthweight infants: how neonatal intensive care unit teams can reduce postnatal malnutrition and prevent growth retardation
Acta Paediatrica
Dec 2012
Extremely low birthweight infants: how neonatal intensive care unit teams can reduce postnatal malnutrition and prevent growth retardation
Aim: To evaluate the impact of an improved nutritional policy for extremely low birthweight (ELBW) infants on nutritional deficits and postnatal growth. Method: We compared two groups of 37 ELBW infants, born before and after the introduction of an improved nutritional policy in April 2006. Group A (born 2005 to early..Hospital-wide breastfeeding rates vs. breastmilk provision for very-low-birth-weight infants
Acta Paediatrica
Dec 2012
Hospital-wide breastfeeding rates vs. breastmilk provision for very-low-birth-weight infants
Aim: To investigate the relationship between breastmilk feeding in very-low-birth-weight infants in the neonatal intensive care unit and breastmilk feeding rates for all newborns by hospital. Methods: This was a cross-sectional study of 111 California hospitals in 2007 and 2008. Correlation coefficients were calculated..Active management of selective intrauterine growth restriction with abnormal Doppler in monochorionic diamniotic twin pregnancies diagnosed in the second trimester of pregnancy
Prenatal Diagnosis
Dec 2012
Active management of selective intrauterine growth restriction with abnormal Doppler in monochorionic diamniotic twin pregnancies diagnosed in the second trimester of pregnancy
Objective: This study aims to compare outcomes of active management of monochorionic diamniotic twin pregnancies complicated with severe intrauterine growth restriction (IUGR) of one twin before 24 weeks with continuous or intermittent absent or reversed end-diastolic flow (AREDF) in the umbilical artery, with or..Neonatal and parental predictors of executive function in very preterm children
Acta Paediatrica
Dec 2012
Neonatal and parental predictors of executive function in very preterm children
Aim: To examine neonatal and parental predictors of executive function in very preterm (gestational age ≤30 weeks) children aged 4.0–12.0 years. Methods: Two-hundred very preterm (mean age 8.2 ± 2.5 years) children without severe disabilities, born between 1996 and 2004, were assessed with measures of executive..Human fetal sacrococcygeal extension or ‘tail’ in the second trimester: prenatal diagnosis, associated findings, and clinical outcome
Prenatal Diagnosis
Dec 2012
Human fetal sacrococcygeal extension or ‘tail’ in the second trimester: prenatal diagnosis, associated findings, and clinical outcome
Background: There are over 30 cases of prenatally diagnosed sacral extensions or human ‘tails’ in the literature, including isolated and syndromic etiologies. Most cases were reported to resolve by the second trimester and postnatal course was benign. Our objective was to describe the prenatal findings, associated..Maternal Hypertensive Disorders during Pregnancy and Mild Cognitive Limitations in the Offspring
Paediatric and Perinatal Epidemiology
Dec 2012
Maternal Hypertensive Disorders during Pregnancy and Mild Cognitive Limitations in the Offspring
Background: It remains unclear whether maternal hypertensive disorders could impact cognitive development of the child. The aim of this study was to explore the association between hypertensive disorders and other maternal biological and social factors on the risk of mild cognitive limitations (intelligence quotient..Use of heated humidified high-flow nasal cannula oxygen in neonates: a UK wide survey
Acta Paediatrica
Dec 2012
Use of heated humidified high-flow nasal cannula oxygen in neonates: a UK wide survey
Aim: Heated humidified high-flow nasal cannula (HHHFNC) oxygen is a relatively new form of respiratory support and is increasing in popularity despite lack of supportive evidence and amid safety concerns. We investigated the prevalence of its use in tertiary neonatal units in the UK. Method: Electronic survey. Results:..Using Parent Questionnaires to Assess Neurodevelopment in Former Preterm Infants: A Validation Study
Paediatric and Perinatal Epidemiology
Dec 2012
Using Parent Questionnaires to Assess Neurodevelopment in Former Preterm Infants: A Validation Study
Background: Former preterm and very low birthweight infants require close neurodevelopmental surveillance after hospital discharge, but in-person professional testing is resource-intensive and inconvenient for families. A standardised developmental questionnaire completed by parents offers an alternative to in-person..The Effect of Pregnancy Intention on Maternal Prenatal Behaviours and Parent and Child Health: Results of an Irish Cohort Study
Paediatric and Perinatal Epidemiology
Dec 2012
The Effect of Pregnancy Intention on Maternal Prenatal Behaviours and Parent and Child Health: Results of an Irish Cohort Study
Background: Unintended pregnancy is associated with increased risk for adverse neonatal and early childhood outcomes spanning an array of indicators, but it remains unclear whether these risks hold independent of other biological, social and environmental risk factors. Methods: This study uses data from the first wave..Influence of Maternal and Paternal Birthweight on Offspring Birthweight – a Population-based Intergenerational Study
Paediatric and Perinatal Epidemiology
Nov 2012
Influence of Maternal and Paternal Birthweight on Offspring Birthweight – a Population-based Intergenerational Study
Background The correlation between infant birthweight and parental birthweight has received substantial interest. However, fewer studies including the birthweight of the father have had access to large sets of population-based data. The objective of this study is to examine the influence of maternal and paternal..A nomogram for perioperative prognostic risk-assessment in twin–twin transfusion syndrome
Prenatal Diagnosis
Nov 2012
A nomogram for perioperative prognostic risk-assessment in twin–twin transfusion syndrome
Objective: Prognostic assessment in twin-to-twin transfusion syndrome (TTTS) is ill-defined. The objective of this study is to define a perioperative prognostic score for TTTS treated by percutaneous laser coagulation. Methods: Consecutive cases of TTTS treated by percutaneous fetoscopic laser coagulation over a 6-year..Analytical goal setting in aneuploidy screening: within person biological variability of first trimester biochemical markers
Prenatal Diagnosis
Nov 2012
Analytical goal setting in aneuploidy screening: within person biological variability of first trimester biochemical markers
Objective: To determine the average within person biological variability of free-β human chorionic gonadotrophin (free hCGβ), intact hCG and pregnancy-associated plasma protein A (PAPP-A), and to establish analytical goals for the measurement of these markers when used in first trimester screening. Methods: Free hCGβ,..Correction of first trimester biochemical aneuploidy screening markers for smoking status: influence of gestational age, maternal ethnicity and cigarette dosage
Prenatal Diagnosis
Nov 2012
Correction of first trimester biochemical aneuploidy screening markers for smoking status: influence of gestational age, maternal ethnicity and cigarette dosage
Objective: To examine the gestational age, maternal ethnicity and cigarette dosage effects of the reduction of maternal serum pregnancy-associated plasma protein A (PAPP-A) and free-β human chorionic gonadotrophin (free hCGβ) in smokers. Methods: Maternal serum PAPP-A and free hCGβ corrected for confounders, excluding..Antibiotic Use and Misuse in the Neonatal Intensive Care Unit
Clinics in Perinatology
Jan 2012
Antibiotic Use and Misuse in the Neonatal Intensive Care Unit
Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common..Neonatal Diuretic Therapy: Furosemide, Thiazides, and Spironolactone
Clinics in Perinatology
Jan 2012
Neonatal Diuretic Therapy: Furosemide, Thiazides, and Spironolactone
Diuretics are commonly used to treat infants with oxygen-dependent chronic lung disease. However, there are limited data suggesting a beneficial effect of long-term diuretic therapy on pulmonary function or clinical outcome in this population. Furthermore, data available for review were primarily obtained before the..Osteogenesis imperfecta type VIII: A case report
Journal of Neonatal Nursing
Dec 2011
Osteogenesis imperfecta type VIII: A case report
Osteogenesis imperfecta is a genetic bone disorder that requires a multi-disciplinary healthcare team to achieve optimal patient outcomes. It is most recognized by excessive brittleness of the bones, and has several classification types, with varying levels of severity. In 2007, type VIII was added to the..Perinatal outcomes and congenital abnormalities in the newborns of women affected by the 2009 pandemic influenza A (H1N1) in Beijing, China
International Journal of Gynecology & Obstetrics
Nov 2011
Perinatal outcomes and congenital abnormalities in the newborns of women affected by the 2009 pandemic influenza A (H1N1) in Beijing, China
Objective: To investigate the pregnancy complications, perinatal outcomes, and congenital abnormalities (CAs) that occurred in Beijing, China, when pregnant women became infected with the 2009 pandemic influenza A (H1N1) (H1N1pdm). Methods: Pregnancy complications, perinatal outcomes, and CAs were compared among 3..Evidence for the clinical management of chorioamnionitis
Seminars in Fetal and Neonatal Medicine
Oct 2011
Evidence for the clinical management of chorioamnionitis
Acute chorioamnionitis or intra-amniotic infection is defined by maternal fever in association with at least one additional clinical criterion including maternal or fetal tachycardia, maternal leukocytosis, uterine tenderness, or foul amniotic fluid odor. In clinically uncertain cases, the diagnosis can be augmented by..Intrauterine infection and preterm labor
Seminars in Fetal and Neonatal Medicine
Sep 2011
Intrauterine infection and preterm labor
Preterm labor is defined as labor that begins before 37 completed weeks of pregnancy. More than 12% of infants born in the USA are preterm. At least 40% of preterm births are associated with intrauterine infection. Toll-like receptors (TLRs) are members of a family of cell-surface proteins responsible for recognition..Longitudinal Myocardial Contribution to Peak Systolic Flow and Stroke Volume in the Neonatal Heart
Pediatric Research
Sep 2011
Longitudinal Myocardial Contribution to Peak Systolic Flow and Stroke Volume in the Neonatal Heart
Systolic longitudinal myocardial function is important for cardiac ejection. Data describing hemodynamic determinants and the time course of myocardial longitudinal contraction as measured by tissue Doppler are lacking. Ten newborn pigs were used for invasive hemodynamic investigation. Tissue Doppler assessment of the..Efficacy of an infection control programme in reducing nosocomial bloodstream infections in a Senegalese neonatal unit
Journal of Hospital Infection
Jun 2011
Efficacy of an infection control programme in reducing nosocomial bloodstream infections in a Senegalese neonatal unit
Neonatal nosocomial infections are public health threats in the developing world, and successful interventions are rarely reported. A before-and-after study was conducted in the neonatal unit of the Hopital Principal de Dakar, Senegal to assess the efficacy of a multi-faceted hospital infection control programme..Role of the gut as a primary lymphoid organ
Immunology Letters
Jun 2011
Role of the gut as a primary lymphoid organ
The TCR-alphabeta/gammadelta CD8alphaalpha intraepithelial T lymphocytes (T-IEL) located in the gut mucosa of the small intestine are an abundant population believed to have a major role in ensuring the integrity of the gut wall. Here, we describe their unique characteristics and the controversies regarding the origin..
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