Men's Health/Andrology Medical Journal Abstracts
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A national study of the provision of oncology sperm banking services among Canadian fertility clinics
European Journal of Cancer Care
Feb 2013
A national study of the provision of oncology sperm banking services among Canadian fertility clinics
The purpose of this study was to survey the current state of oncology sperm banking services provided by fertility clinics across Canada. A total of 78 Canadian fertility facilities were invited to complete a questionnaire related to the availability, accessibility, affordability and utilisation of sperm banking..Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?
The Prostate
Jan 2013
Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?
Background: Advanced prostate cancer is treated by hormone ablation therapy. However, despite an initial response, the majority of men relapse to develop castration-resistant disease for which there are no effective treatments. We have previously shown that manipulating individual proteins has only minor alterations on..A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer
Cancer Genetics
Jan 2013
A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer
Since the identification of the TMPRSS2-ERG rearrangement as the most common fusion event in prostate cancer, various methods have been developed to detect this rearrangement and to study its prognostic significance. We report a novel four-color fluorescence in situ hybridization (FISH) assay that detects not only the..Erectile dysfunction in heart failure patients: a critical reappraisal
Andrology
Jan 2013
Erectile dysfunction in heart failure patients: a critical reappraisal
Heart failure (HF) is a complex clinical syndrome with a constantly increasing incidence and prevalence in western countries. Total absence of sexual activity is registered in 30% of HF patients. Moreover, HF-induced reduction in exercise tolerance, side effects of HF medications and the coexistence of shared risk..Consumption of deep-fried foods and risk of prostate cancer
The Prostate
Jan 2013
Consumption of deep-fried foods and risk of prostate cancer
Background: Evidence suggests that high-heat cooking methods may increase the risk of prostate cancer (PCa). The addition of oil/fat, as in deep-frying, may be of particular concern, and has not specifically been investigated in relation to PCa. Potential mechanisms include the formation of potentially carcinogenic..Phase II open label, multi-center clinical trial of modulation of intermediate endpoint biomarkers by 1α-hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
The Prostate
Jan 2013
Phase II open label, multi-center clinical trial of modulation of intermediate endpoint biomarkers by 1α-hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
Background: Prostate cancer is the most common malignancy and second leading cause of cancer related deaths in American men supporting the study of prostate cancer chemoprevention. Major risk factors for this disease have been associated with low serum levels of vitamin D. Here, we evaluate the biologic activity of a..Prognostic value of ERG oncoprotein in prostate cancer recurrence and cause-specific mortality
The Prostate
Jan 2013
Prognostic value of ERG oncoprotein in prostate cancer recurrence and cause-specific mortality
Background: ETS-related gene (ERG) protein is present in 40–70% of prostate cancer and is correlated with TMPRSS2-ERG gene rearrangements. This study evaluated ERG expression at radical prostatectomy to determine whether it was predictive of earlier relapse or prostate cancer-specific mortality (PCSM). Methods: One..Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model
The Prostate
Jan 2013
Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model
Background: Bone metastasis is a serious problem for individuals with prostate cancer, and the effects of the anticancer drug docetaxel (DTX) are insufficient. We therefore examined the therapeutic potential of magnetic cationic liposomes (MCL) in a novel rat model that allows the evaluation of tumor immunity. The..A novel canine model for prostate cancer
The Prostate
Jan 2013
A novel canine model for prostate cancer
Background: No existing animal model fully recapitulates all features of human prostate cancer. The dog is the only large mammal, besides humans, that commonly develops spontaneous prostate cancer. Canine prostate cancer features many similarities with its human counterpart. We sought to develop a canine model of..High-grade prostate cancer and biochemical recurrence after radical prostatectomy among men using 5α-reductase inhibitors and alpha-blockers
The Prostate
Jan 2013
High-grade prostate cancer and biochemical recurrence after radical prostatectomy among men using 5α-reductase inhibitors and alpha-blockers
Background: Two clinical trials have shown that users of 5α-reductase inhibitors finasteride and dutasteride (5-ARIs) have reduced overall prostate cancer risk, while the proportion of high-grade tumors is increased. We studied tumor characteristics, risk of biochemical recurrence and mortality after radical..Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases
The Prostate
Jan 2013
Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases
Background: Approximately 90% of patients who die of Prostate Cancer (PCa) have bone metastases, which promote a spectrum of osteoblastic, osteolytic or mixed bone responses. Numerous secreted proteins have been reported to promote osteoblastic or osteolytic bone responses. We determined whether previously identified..Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell
The Prostate
Jan 2013
Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell
Background: The role of CXCL1 in prostate cancer (PCa) progression has been poorly investigated. A limitation of previous studies is linked to the use of human PCa cell lines PC3 and DU145, producing CXCL8 at levels strongly exceeding CXCL1 levels. Moreover, in mouse models the sharing of CXCR2 receptor by both ligands..The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
The Prostate
Jan 2013
The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
Background: The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined. Methods: We assayed for the presence of the G84E mutation in 3,515 prostate cancer..Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples
Andrology
Jan 2013
Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples
Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and..Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse
Andrology
Jan 2013
Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse
The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8−/− mice lacking Sox9 in Sertoli cells fail to form testis cords and cannot establish spermatogenesis. Although genetic and histological data show an important..A guanidinylated bioreducible polymer as a novel gene carrier to the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction
Andrology
Jan 2013
A guanidinylated bioreducible polymer as a novel gene carrier to the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction
A prerequisite for the successful clinical application of gene therapy in erectile dysfunction (ED) is the availability of safe and efficient gene delivery systems. The aim of this study was to examine the effectiveness of guanidinylated bioreducible polymer (GBP) polyplexes for gene delivery systems, which take..Sexual intercourse with leucocytospermic men may be a possible booster of oxidative stress in female partners of infertile couples
Andrology
Jan 2013
Sexual intercourse with leucocytospermic men may be a possible booster of oxidative stress in female partners of infertile couples
Human semen has undoubtedly significant influence on the organism of the female counterpart. At the same time there are no studies in English literature investigating the influence of sexual intercourse on oxidative stress level in women's organism. Seventeen infertile couples where male partners were with (n = 5) or..On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid
Andrology
Jan 2013
On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid
Oxidative stress is known to have a major impact on human sperm function and, as a result, there is a need to develop sensitive methods for measuring reactive oxygen species (ROS) generation by these cells. A variety of techniques have been developed for this purpose including chemiluminescence (luminol and lucigenin),..Posthumous sperm utilization in men presenting for sperm banking: an analysis of patient choice
Andrology
Jan 2013
Posthumous sperm utilization in men presenting for sperm banking: an analysis of patient choice
The question remains as to whether or not men would agree to posthumous sperm use for pregnancy initiation. Often, these individuals' lives are suddenly interrupted and prior consent is rarely given. Therefore, post-mortem retrieval or use of these spermatozoa remains controversial and the incidence of consent for..Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders
Andrology
Jan 2013
Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders
Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whether..Sperm counts may have declined in young university students in Southern Spain
Andrology
Jan 2013
Sperm counts may have declined in young university students in Southern Spain
Several studies have investigated temporal trends in semen quality in Northern Europe, but none has examined this question in Southern Europe. A prior study conducted in Almeria Province (Southern Spain) reported higher sperm count and concentration among Spanish young men recruited from 2001 to 2002 compared with..High variability in results of semen analysis in Andrology Laboratories in Tuscany (Italy): the experience of an external quality control (EQC) programme
Andrology
Jan 2013
High variability in results of semen analysis in Andrology Laboratories in Tuscany (Italy): the experience of an external quality control (EQC) programme
We report the results of the first three trials of an external quality control (EQC) programme performed in 71 laboratories executing semen analysis in Tuscany Region (Italy). At the end of the second trial, participants were invited to attend a teaching course illustrating and inviting to adhere to procedures..A randomized, double-blind, crossover, placebo-controlled comparative clinical trial of arginine aspartate plus adenosine monophosphate for the intermittent treatment of male erectile dysfunction
Andrology
Dec 2012
A randomized, double-blind, crossover, placebo-controlled comparative clinical trial of arginine aspartate plus adenosine monophosphate for the intermittent treatment of male erectile dysfunction
Efficacy and safety of l-arginine aspartate 8 g combined with 200 mg of adenosine monophosphate (AA) with placebo (PL) alone for intermittent treatment of mild-to-moderate erectile dysfunction (ED) were compared. The study design was a double-blind, PL-controlled, two-way crossover randomized clinical trial with 26..Prostate specific membrane antigen (PSMA): A novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells
The Prostate
Dec 2012
Prostate specific membrane antigen (PSMA): A novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells
Background: Regulated activation of p38 is crucial for cell proliferation, survival, and metabolism. Our previous studies had showed that prostate specific membrane antigen (PSMA) can facilitate the proliferation, migration, survival of the LNCaP prostate cancer cell line, but the mechanisms are poorly defined...One thousand genomes imputation in the national cancer institute breast and prostate cancer cohort consortium aggressive prostate cancer genome-wide association study
The Prostate
Dec 2012
One thousand genomes imputation in the national cancer institute breast and prostate cancer cohort consortium aggressive prostate cancer genome-wide association study
Background: Genotype imputation substantially increases available markers for analysis in genome-wide association studies (GWAS) by leveraging linkage disequilibrium from a reference panel. We sought to (i) investigate the performance of imputation from the August 2010 release of the 1000 Genomes Project (1000GP) in an..Occurrence of Dysplasia and Human Papilloma Virus Typing in Penile Condylomas
Urology
Nov 2012
Occurrence of Dysplasia and Human Papilloma Virus Typing in Penile Condylomas
Objective: To determine the incidence of dysplasia as a preneoplastic change and high-risk human papilloma virus (HPV) infection in penile condylomas, which are common HPV-related lesions and considered a risk factor for penile cancer. Methods: Histologic analysis was done of 58 consecutive penile condylomas with..Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer
The Prostate
Sep 2012
Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer
Background: Dystroglycan is a ubiquitously expressed cell adhesion molecule frequently found to be altered or reduced in adenocarcinomas, however the mechanisms or consequences of dystroglycan loss have not been studied extensively. Methods: We examined the consequence of overexpression or RNAi depletion of..Delayed radical prostatectomy for intermediate-risk prostate cancer is associated with biochemical recurrence: Possible implications for active surveillance from the SEARCH database
The Prostate
Sep 2012
Delayed radical prostatectomy for intermediate-risk prostate cancer is associated with biochemical recurrence: Possible implications for active surveillance from the SEARCH database
Introduction: Active surveillance (AS) is increasingly accepted as appropriate management for low-risk prostate cancer (PC) patients. It is unknown whether delaying radical prostatectomy (RP) is associated with increased risk of biochemical recurrence (BCR) for men with intermediate-risk PC. Methods: We performed a..Functional p53 determines docetaxel sensitivity in prostate cancer cells
The Prostate
Sep 2012
Functional p53 determines docetaxel sensitivity in prostate cancer cells
Background: Docetaxel is the first line treatment for castration resistant prostate cancer (CRPC). However, docetaxel resistance rapidly develops. Identifying the critical mechanisms giving rise to docetaxel resistance is the major challenge in advanced prostate cancer. Methods: The effects of docetaxel on human DU145,..Gene expression analysis in prostate cancer: The importance of the endogenous control
The Prostate
Sep 2012
Gene expression analysis in prostate cancer: The importance of the endogenous control
Background: Aberrant gene expression is a hallmark of cancer. Quantitative reverse-transcription PCR (qRT-PCR) is the gold-standard for quantifying gene expression, and commonly employs a house-keeping gene (HKG) as an endogenous control to normalize results; the choice of which is critical for accurate data..Prostate epithelial AR inactivation leads to increased intraprostatic androgen synthesis
The Prostate
Sep 2012
Prostate epithelial AR inactivation leads to increased intraprostatic androgen synthesis
Background: Regulation of steroid synthesis within the prostate is not well understood. In this study, we examined androgen synthesis and metabolism in the mouse prostate. Methods: Using LC–MSMS steroid assays, immunohistochemistry and real-time PCR we examined the role of prostate epithelial AR in regulating 5αR..Histopathologic features of atypical glands on prostate biopsy: Nucleolar size is a predictor of subsequent detection of prostatic adenocarcinoma
The Prostate
Aug 2012
Histopathologic features of atypical glands on prostate biopsy: Nucleolar size is a predictor of subsequent detection of prostatic adenocarcinoma
Background: Patients whose prostate biopsy reveals the presence of atypical glands suspicious for carcinoma (AGSC) are subject to close monitoring and repeat biopsies, perhaps unnecessarily, as clinicians do not have a clear basis for understanding and stratifying the significance of these findings. Methods: In a..Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo
The Prostate
Aug 2012
Androgen deprivation induces senescence characteristics in prostate cancer cells in vitro and in vivo
Background: The treatment of non-localized prostate cancer involves androgen deprivation (AD) therapy which results in tumor regression. Apoptosis has been implicated in the tumor response to AD, but constitutes a small fraction of the total tumor at any time. Cellular senescence is a response to sub-lethal stress in..PSMA-targeted SPECT agents: Mode of binding effect on in vitro performance
The Prostate
Aug 2012
PSMA-targeted SPECT agents: Mode of binding effect on in vitro performance
Background: The enzyme-biomarker prostate-specific membrane antigen (PSMA) is an active target for imaging and therapeutic applications for prostate cancer. The internalization of PSMA has been shown to vary with inhibitors' mode of binding: irreversible, slowly reversible, and reversible. Methods: In the present..Anterior gradient 2 (AGR2): Blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype
The Prostate
Aug 2012
Anterior gradient 2 (AGR2): Blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype
Background: Anterior gradient 2 (AGR2) is associated with metastatic progression in prostate cancer cells as well as other normal and malignant tissues. We investigated AGR2 expression in patients with metastatic prostate cancer. Methods: Blood was collected from 44 patients with metastatic prostate cancer separated..Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer
The Prostate
Aug 2012
Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer
Background: Recent studies show that microRNAs (miRNAs), small non-coding RNAs that negatively regulate gene expression, may have potential for monitoring cancer status. We investigated circulating miRNAs in prostate cancer that may be associated with the progression of hormone-sensitive primary tumors to metastatic..Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer
The Prostate
Aug 2012
Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer
Purpose: This study was conducted to investigate the effect of Se supplementation on prostate cancer incidence in men at high risk for prostate cancer. Methods: A Phase 3 randomized, double-blind, placebo-controlled clinical trial was conducted in 699 men at high risk for prostate cancer (prostate specific antigen..Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa)
The Prostate
Aug 2012
Expression of proton-coupled oligopeptide transporter (POTs) in prostate of mice and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa)
Background: Proton-coupled oligopeptide transporters (POTs) serve as integral membrane protein for the cellular uptake of di/tripeptide. Prostate has a large requirement of nutriment for its function to produce and secrete prostatic fluid. Besides, prostate suffered from limited therapy effect of drug treatment. Thus..Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades
The Prostate
Aug 2012
Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades
Background: Akt/mTOR/S6K1 signaling cascades play an important role both in the survival and proliferation of tumor cells. Methods: In the present study, we investigated the effects of embelin (EB), identified primarily from the Embelia ribes plant, on the Akt/mTOR/S6K1 activation, associated gene products, cellular..Human papillomavirus and Epstein Barr virus in prostate cancer: Koilocytes indicate potential oncogenic influences of human papillomavirus in prostate cancer
The Prostate
Jul 2012
Human papillomavirus and Epstein Barr virus in prostate cancer: Koilocytes indicate potential oncogenic influences of human papillomavirus in prostate cancer
Introduction: The purpose of this study is to determine if high risk human papillomaviruses (HPV) and Epstein Barr virus (EBV) are both present in the same prostate cancer specimens. Methods: We used a range of analytical techniques including in situ polymerase chain reaction (IS-PCR) and standard liquid PCR followed..Serum zinc and prostate cancer risk in a nested case–control study: The multiethnic cohort
The Prostate
Jul 2012
Serum zinc and prostate cancer risk in a nested case–control study: The multiethnic cohort
Background: Experimental studies have provided evidence that zinc has a protective effect against development and progression of prostate cancer. However, epidemiological studies have reported inconsistent findings. We evaluated the association between prediagnostic serum zinc and prostate cancer risk in a cohort of..Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy
The Prostate
Jul 2012
Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy
Background: Prostate health index (phi) and prostate cancer antigen 3 (PCA3) have been recently proposed as novel biomarkers for prostate cancer (PCa). We assessed the diagnostic performance of these biomarkers, alone or in combination, in men undergoing first prostate biopsy for suspicion of PCa. Methods: One hundred..Urine TMPRSS2:ERG fusion transcript integrated with PCA3 score, genotyping, and biological features are correlated to the results of prostatic biopsies in men at risk of prostate cancer
The Prostate
Jul 2012
Urine TMPRSS2:ERG fusion transcript integrated with PCA3 score, genotyping, and biological features are correlated to the results of prostatic biopsies in men at risk of prostate cancer
Background: Detection of fusion gene TMPRSS2:ERG transcripts in urine have been recently described in order to refine urine-based detection of prostate cancer (PCa), but data its clinical impact remain scarce. We aimed at investigating the correlation of TMPRSS2:ERG, prostate cancer antigen 3 (PCA3), prostate specific..Use of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy
The Prostate
Jul 2012
Use of β-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy
Background: Experimental evidence suggests a role for the β2-adrenergic receptor pathway in prostate cancer (PCa). We have investigated the association of β-blocker use with PCa incidence and survival in a Norwegian cohort. Methods: Data from the Oslo II study in 2000 (n = 6515) were linked with information from the..The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way
The Prostate
Jul 2012
The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way
Background: The androgen receptor (AR) AR-V7 splice isoform is a constitutively active outlaw transcription factor. Transition of prostate cancer (PC) to the castration-resistant phenotype correlates with AR-V7 accumulation, suggesting that PC progression in patients refractory to conventional therapy is due to the..Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury
The Prostate
Jul 2012
Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury
Background: We compared periprostatic implantation (PPI) and intracavernosal injection (ICI) of human adipose tissue-derived stem cell (ADSC) to facilitate recovery of erectile function in a rat model of cavernous nerve (CN) injury. Methods: Bilateral CN dissection (BCND) was induced in Sprague–Dawley rats. After BCND..The Role of the Prostatic Vasculature as a Landmark for Nerve Sparing During Robot-Assisted Radical Prostatectomy
European Urology
Dec 2011
The Role of the Prostatic Vasculature as a Landmark for Nerve Sparing During Robot-Assisted Radical Prostatectomy
Background: Macroscopic landmarks are lacking to identify the cavernosal nerves (CNs) during radical prostatectomy. The prostatic and capsular arteries run along the lateral border of the prostate and could help identify the location of the CNs during robotassisted radical prostatectomy (RARP). Objective: Describe the..Focused Ultrasound to Expel Calculi From the Kidney
The Journal of Urology
Dec 2011
Focused Ultrasound to Expel Calculi From the Kidney
Purpose: A persistent stone burden after renal stone treatment may result in future patient morbidity and potentially lead to additional surgery. This problem is particularly common after treatment of lower pole stones. We describe a potential noninvasive therapeutic option using ultrasound waves to create a force..Near Infrared Spectroscopy to Diagnose Experimental Testicular Torsion: Comparison With Doppler Ultrasound and Immunohistochemical Correlation of Tissue Oxygenation and Viability
The Journal of Urology
Dec 2011
Near Infrared Spectroscopy to Diagnose Experimental Testicular Torsion: Comparison With Doppler Ultrasound and Immunohistochemical Correlation of Tissue Oxygenation and Viability
Purpose: Near infrared spectroscopy measures tissue oxygenation even when there is complete cessation of blood flow. We evaluated near infrared spectroscopy to diagnose testicular torsion and blindly compared its accuracy with that of Doppler ultrasound. We also compared it by immunohistochemical evaluation of hypoxia..G-Protein Coupled Receptor Kinase 5 Regulates Prostate Tumor Growth
The Journal of Urology
Nov 2011
G-Protein Coupled Receptor Kinase 5 Regulates Prostate Tumor Growth
Purpose: The limited success of cancer therapeutics is largely attributable to the ability of cancer to become resistant to conventional cytotoxic chemotherapy. Thus, further identification of signaling molecules and pathways that influence tumorigenesis is needed to increase the overall therapeutic options. GRKs,..The Effect of Body Mass Index on the Outcomes of Varicocelectomy
The Journal of Urology
Nov 2011
The Effect of Body Mass Index on the Outcomes of Varicocelectomy
Purpose: Obesity is recognized as a potential contributor to male factor infertility. There are no studies to date to our knowledge that have examined the success of varicocelectomy in obese men. We determined if body mass index significantly affects the outcome of varicocelectomy. Materials and Methods: Retrospective..Predictors of Warm Ischemia Time and Perioperative Complications in a Multicenter, International Series of Robot-Assisted Partial Nephrectomy
European Urology
Nov 2011
Predictors of Warm Ischemia Time and Perioperative Complications in a Multicenter, International Series of Robot-Assisted Partial Nephrectomy
Background: Warm ischemia time (WIT) and complication rates are two important parameters for evaluating the perioperative results of robot-assisted partial nephrectomy (RAPN). Few data are available about the clinical predictors of WIT and overall complications. Objective: To identify clinical predictors of WIT and..Factors Influencing Men’s Decisions Regarding Prostate Cancer Screening: A Qualitative Study
Journal of Community Health
Sep 2011
Factors Influencing Men’s Decisions Regarding Prostate Cancer Screening: A Qualitative Study
Shared decision making is recommended before prostate cancer screening. Little is known regarding reasons why men choose to get or not get prostate cancer screening, particularly in white or Hispanic men. We conducted semi-structured in-depth interviews of 64 men, age 50 years and over, purposively sampled from men who..Non-Hodgkin's lymphoma of the testicle and bilateral adrenals detected by (18)F-FDG PET/CT
Experimental and Therapeutic Medicine
Jun 2011
Non-Hodgkin's lymphoma of the testicle and bilateral adrenals detected by (18)F-FDG PET/CT
Lymphoma, particularly non-Hodgkin's lymphoma, may occur in sites other than the lymph nodes, i.e., extranodal lymphoma, which occurs in approximately 40% of total lymphoma cases. However, simultaneous detection of multiple extranodal involvements at presentation is quite uncommon. Here, we report a rare case of a..Serum cytokine profiles in patients with prostate carcinoma
Experimental and Therapeutic Medicine
Jun 2011
Serum cytokine profiles in patients with prostate carcinoma
It has been suggested that various cytokines are associated with the pathophysiology of prostate carcinoma (Pca). We profiled ten cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α) in the serum levels of 11 patients with organ-confined Pca, 15 with advanced Pca without cachexia, 8 with..
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