Urological and Kidney Diseases Medical Journal Abstracts
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Relationship Between Predictors of the Risk of Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome in Men With Moderate to Severe Lower Urinary Tract Symptoms
Urology
Apr 2013
Relationship Between Predictors of the Risk of Clinical Progression of Benign Prostatic Hyperplasia and Metabolic Syndrome in Men With Moderate to Severe Lower Urinary Tract Symptoms
Objective: To investigate the association between the metabolic syndrome (MetS) and the predictors of the progression of benign prostatic hyperplasia (BPH). Materials and Methods: A total of 778 male police officers in their 50s with moderate to severe lower urinary tract symptoms (International Prostate Symptom..Acute Renal Failure Caused by Bilateral Ureteral Herniation Through the Sciatic Foramen
Urology
Apr 2013
Acute Renal Failure Caused by Bilateral Ureteral Herniation Through the Sciatic Foramen
Ureteral herniation is rare. Only a few cases of bilateral ureterosciatic herniation have been reported. We report the case of a 74-year-old woman with flank pain and acute renal failure. The initial ultrasound scan showed bilateral hydronephrosis. Follow-up computed tomography imaging demonstrated sciatic herniation..Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation
Journal of Nephrology
Apr 2013
Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation
Introduction: Mitochondrial dysfunction plays an important role in acute kidney injury (AKI). Mitochondrial fission regulated by dynamin-related protein 1 (Drp-1) impairs the function of the mitochondria and the survival of cells. This study was conducted to explore the effects of suppression of Drp-1 accumulation in..Phosphate binders in moderate chronic kidney disease: where do we stand?
Journal of Nephrology
Mar 2013
Phosphate binders in moderate chronic kidney disease: where do we stand?
Phosphate levels are strikingly associated with poor outcomes in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. Numerous epidemiological studies have repeatedly documented a worrisome link between serum phosphorus and adverse outcome in CKD stages 3 and 4. Notably, some but not all series..Conservative Management of Urorectal Fistulae
Urology
Mar 2013
Conservative Management of Urorectal Fistulae
Objective: To characterize conservative management of urorectal fistulae (URF). Methods: URF are a recognized but rare complication of treatments for prostate and rectal cancers. URF can lead to incontinence, fecaluria, pain, urinary infection, and sepsis, and thus are usually treated surgically. We present a series of..Robotic Partial Nephrectomy for Renal Cell Carcinomas With Venous Tumor Thrombus
Urology
Mar 2013
Robotic Partial Nephrectomy for Renal Cell Carcinomas With Venous Tumor Thrombus
Objective: To describe the first report of robotic partial nephrectomies (RPNs) for renal cell carcinoma (RCC) with venous tumor thrombus (VTT). Methods: Partial nephrectomy for RCC extending into the renal vein has been described in limited fashion, but such a complex procedure has not previously been reported in..Nerve growth factor (NGF): a potential urinary biomarker for overactive bladder syndrome (OAB)?
BJU International
Feb 2013
Nerve growth factor (NGF): a potential urinary biomarker for overactive bladder syndrome (OAB)?
What's known on the subject? and What does the study add? The search for a biomarker in overactive bladder syndrome (OAB) is an emerging field of interest, as bladder dysfunction is a common complaint that causes significant morbidity. A biomarker may give us insight as a diagnostic tool, and also inform us about how..Lack of predictive correlation between peripheral arterial tone and colour flow Doppler parameters in men with erectile dysfunction
BJU International
Feb 2013
Lack of predictive correlation between peripheral arterial tone and colour flow Doppler parameters in men with erectile dysfunction
Objective To evaluate whether peripheral arterial tone (PAT) can predict the results of penile colour flow Doppler in the evaluation of erectile dysfunction (ED). Patients and Methods Fifty men presenting to an ED clinic were tested with an Endo-PAT2000 machine (Itamar Medical, Caesarea, Israel), which assessed..Refractory chronic pelvic pain syndrome in men: can transcutaneous electrical nerve stimulation help?
BJU International
Feb 2013
Refractory chronic pelvic pain syndrome in men: can transcutaneous electrical nerve stimulation help?
Objective: To evaluate the effect of transcutaneous electrical nerve stimulation (TENS) for treating men with refractory chronic pelvic pain syndrome (CPPS). Patients and Methods: A consecutive series of 60 men treated with TENS for refractory CPPS was evaluated prospectively at an academic tertiary referral centre...Antidiuretic effect of antimuscarinic agents in rat model depends on C-fibre afferent nerves in the bladder
BJU International
Feb 2013
Antidiuretic effect of antimuscarinic agents in rat model depends on C-fibre afferent nerves in the bladder
What's known on the subject? and What does the study add? Antichollnergic agents are anticipated to diminish storage symptoms, as well as nocturia. Nevertheless, the effect of this treatment on polyuria related to nocturia is not clear. By subgroup analysis of the data set from a phase III clinical trial of..Efficacy and safety of low-dose desmopressin orally disintegrating tablet in women with nocturia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Journal of Urology
Feb 2013
Efficacy and safety of low-dose desmopressin orally disintegrating tablet in women with nocturia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Purpose: Previous studies suggest a lower dose of desmopressin orally disintegrating tablet (ODT) may be effective in females compared to males with nocturia. This study aimed to confirm the efficacy and safety of desmopressin ODT 25 μg compared with placebo in female patients. Materials and Methods: This 3-month,..Urethral Mobilization for Distal and Midshaft Hypospadias with Chordee
Journal of Urology
Feb 2013
Urethral Mobilization for Distal and Midshaft Hypospadias with Chordee
Purpose: Many options are available for the repair of midshaft to distal hypospadias. Reported complications include poor cosmetic appearance, persistence of chordee, meatal stenosis, and fistula. We hypothesize that advancing intact native urethra will facilitate correction of chordee and minimize complications...Ureteroileal strictures following urinary diversion with an ileal segment: is there a place for endourological treatment at all?
Journal of Urology
Feb 2013
Ureteroileal strictures following urinary diversion with an ileal segment: is there a place for endourological treatment at all?
Purpose: To compare the long-term results of minimally invasive endourological intervention versus open surgical revision in patients with nonmalignant ureteroileal stricture. Materials and Methods: Retrospective evaluation of 74 patients treated for unilateral or bilateral nonmalignant ureteroileal strictures of 85..Efficacy and safety of low-dose desmopressin orally disintegrating tablet in men with nocturia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Journal of Urology
Feb 2013
Efficacy and safety of low-dose desmopressin orally disintegrating tablet in men with nocturia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Purpose: This study investigated the efficacy and safety of desmopressin orally disintegrating tablet (ODT) 50 and 75 μg in men with nocturia (≥2 nocturnal voids). Materials and Methods: This was a 3-month, randomized, double-blind parallel study comparing 50 and 75 μg desmopressin with placebo. The co-primary efficacy..Timing of Curative Treatment for Prostate Cancer: A Systematic Review
European Urology
Feb 2013
Timing of Curative Treatment for Prostate Cancer: A Systematic Review
Context: Delaying definitive therapy unfavourably affects outcomes in many malignancies. Diagnostic, psychological, and logistical reasons but also active surveillance (AS) strategies can lead to treatment delay, an increase in the interval between the diagnosis and treatment of prostate cancer (PCa). Objective: To..Androgen-deprivation Therapy and Diabetes Control Among Diabetic Men with Prostate Cancer
European Urology
Feb 2013
Androgen-deprivation Therapy and Diabetes Control Among Diabetic Men with Prostate Cancer
Background: Androgen-deprivation therapy (ADT) for prostate cancer (PCa) is associated with decreased insulin sensitivity and increased diabetes risk among nondiabetic men. Few data are available about the effects of ADT on diabetes control among men with diabetes. Objective: We examined care for men who had diabetes..Does obesity affect the accuracy of prostate-specific antigen (PSA) for predicting prostate cancer among men undergoing prostate biopsy
BJU International
Feb 2013
Does obesity affect the accuracy of prostate-specific antigen (PSA) for predicting prostate cancer among men undergoing prostate biopsy
What's known on the subject? and What does the study add? As most urologist known, obesity significantly lowers serum PSA levels. So there is some concern about delayed diagnosis of prostate cancer in obese men. In the present study, we found that the accuracy level of PSA for detecting prostate cancer was not..RENAL Nephrometry Score is Associated With Complications After Renal Cryoablation: A Multicenter Analysis
Urology
Feb 2013
RENAL Nephrometry Score is Associated With Complications After Renal Cryoablation: A Multicenter Analysis
Objective: To analyze outcomes and complications of percutaneous (PRC) and laparoscopic renal cryoablation (LRC) using the radius, endophytic, nearness to collecting system, anterior/posterior, and location (RENAL) nephrometry system. Methods: Retrospective multicenter analysis of 154 consecutive patients who underwent..Topical Anesthetic Agents for Premature Ejaculation: A Systematic Review and Meta-analysis
Urology
Feb 2013
Topical Anesthetic Agents for Premature Ejaculation: A Systematic Review and Meta-analysis
Objective: To evaluate the efficacy and safety of topical anesthetic agents for patients with premature ejaculation (PE). Methods: Eligible randomized controlled trials (RCTs) were identified from electronic databases (Cochrane Central Register of Controlled Trials, Medline, and EMBASE) without language restrictions...Improvement of Chronic Peyronie's Disease Symptoms After Diabetic Compensation: A Retrospective Study
Urology
Feb 2013
Improvement of Chronic Peyronie's Disease Symptoms After Diabetic Compensation: A Retrospective Study
Objective: To look for a link between compensation of diabetes in patients with uncompensated/undiagnosed diabetes with chronic Peyronie's disease (PD) and improvement of their PD symptoms. Methods: Thirty-six nonsmoking patients with uncompensated diabetes and PD were studied. The plaque area and pain (ie, PD..Does Positive Family History of Prostate Cancer Increase the Risk of Prostate Cancer on Initial Prostate Biopsy?
Urology
Feb 2013
Does Positive Family History of Prostate Cancer Increase the Risk of Prostate Cancer on Initial Prostate Biopsy?
Objective: To assess the role of family history (FH) in the risk of a positive prostate biopsy (PBx) in a large North American biopsy population as earlier reports showed increased risk of prostate cancer (PCa) in men with a FH, but the risk has been limited to low grade prostate cancer in smaller studies, and the..Three-dimensional Structure of a Parameatal Urethral Cyst by Scanning Electron Microscopy
Urology
Feb 2013
Three-dimensional Structure of a Parameatal Urethral Cyst by Scanning Electron Microscopy
We report scanning electron microscopy (SEM) for a case of parameatal urethral cyst. A 6-year-old Japanese boy presented with a cyst on the right lateral side of the urethral meatus. Histological examination revealed a cyst lined with columnar epithelium. An immunohistochemical study showed positive staining for CK7,..Impact of Robot-assisted Radical Prostatectomy on Lower Urinary Tract Symptoms and Predictive Factors for Symptom Changes: A Longitudinal Study
Urology
Feb 2013
Impact of Robot-assisted Radical Prostatectomy on Lower Urinary Tract Symptoms and Predictive Factors for Symptom Changes: A Longitudinal Study
Objective: To investigate the longitudinal changes in lower urinary tract symptoms (LUTS) after robot-assisted radical prostatectomy (RARP). Methods: Data on 127 patients who underwent RARP and completed the American Urological Association Symptom Score (AUASS) preoperatively and at 3, 6, and 12 months after surgery..Defining Good Candidates for Extraperitoneal Cystectomy: Results from Random Peritoneum Biopsies of 136 Cases
Urology
Feb 2013
Defining Good Candidates for Extraperitoneal Cystectomy: Results from Random Peritoneum Biopsies of 136 Cases
Objective: To define who are good candidates for extraperitoneal cystectomy. Methods: Between April 2009 and April 2012, 136 consecutive patients (median age 63.8 years, range 35-87 years) scheduled for transperitoneal radical cystectomy were included in this study. After the bladder was removed, the peritoneum..The Impact of Ventral Oral Graft Bulbar Urethroplasty on Sexual Life
Urology
Feb 2013
The Impact of Ventral Oral Graft Bulbar Urethroplasty on Sexual Life
Objective: To evaluate the pre- and postoperative aspects of sexual life (SL) in patients with bulbar urethral stricture who underwent ventral oral graft urethroplasty. Methods: Between 2009 and 2010, 52 men (mean age 36 years) were enrolled in our prospective study to ascertain sexual disorders before and after..Hemostatic Effect of New Surgical Glue in Animal Partial Nephrectomy Models
Urology
Feb 2013
Hemostatic Effect of New Surgical Glue in Animal Partial Nephrectomy Models
Objective: To evaluate the hemostatic effect of newly developed medical adhesive in animal partial nephrectomy models. Materials and Methods: A total of 30 experimental rabbits were used in the first study. After clamping the renal vessels, partial nephrectomy was performed up to the opening of the calices. Bioglue was..Causative Pathogens, Antibiotic Sensitivity, Resistance Patterns, and Severity in a Contemporary Series of Fournier's Gangrene
Urology
Feb 2013
Causative Pathogens, Antibiotic Sensitivity, Resistance Patterns, and Severity in a Contemporary Series of Fournier's Gangrene
Objective: To identify the causative pathogens and evaluate the antibiotic sensitivity, resistance patterns, and virulence in a contemporary series of patients with Fournier's gangrene. Materials and Methods: The medical records of 41 consecutive cases of Fournier's gangrene were evaluated. The patient demographics,..Indium-111–labeled Girentuximab ImmunoSPECT as a Diagnostic Tool in Clear Cell Renal Cell Carcinoma
European Urology
Feb 2013
Indium-111–labeled Girentuximab ImmunoSPECT as a Diagnostic Tool in Clear Cell Renal Cell Carcinoma
Background: Improved and more frequent radiologic evaluation has resulted in increased identification of renal masses of unknown origin, which frequently pose a diagnostic dilemma for urologists. Objective: Carbonic anhydrase IX (CAIX) is an antigen ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). The..Chronobiology of micturition: putative role of the circadian clock
Journal of Urology
Feb 2013
Chronobiology of micturition: putative role of the circadian clock
Purpose: Mammals urinate less frequently during sleep period than during awake period, which is modulated by triad factors; decreased arousal level in the brain, decreased urine production rate from the kidneys, and increased functional bladder capacity during sleep. The circadian clock (‘the clock’) is genetic..Psychosocial comorbidities and obesity are associated with lower urinary tract symptoms among children with voiding dysfunction
Journal of Urology
Feb 2013
Psychosocial comorbidities and obesity are associated with lower urinary tract symptoms among children with voiding dysfunction
Purpose: There is emerging awareness of comorbid psychosocial characteristics in children with lower urinary tract (LUT) dysfunction. To explore the prevalence of these comorbidities and their relationship to LUT symptoms, we examined the psychosocial comorbidities and BMI of children with LUT dysfunction. Materials..Chronic Cyclic Bladder Over-Distension Upregulates Hypoxia-Dependent Pathways
Journal of Urology
Feb 2013
Chronic Cyclic Bladder Over-Distension Upregulates Hypoxia-Dependent Pathways
Purpose: Bladder over-distension secondary to anatomic or functional obstruction can eventually lead to pathologic changes, including decreased elasticity and contractile dysfunction. We hypothesize that chronic bladder distension in a murine model will activate hypoxia-dependent signaling pathways despite intermittent..Projected Financial Impact of Non-coverage of Elective Circumcision by Louisiana Medicaid in Boys Aged 0-5
Journal of Urology
Feb 2013
Projected Financial Impact of Non-coverage of Elective Circumcision by Louisiana Medicaid in Boys Aged 0-5
Purpose: Several states, including Louisiana since 2005, no longer cover elective circumcision under Medicaid programs. The recent AAP policy statement recognizes the medical benefits of circumcision and recommends the removal of financial barriers to this procedure. Cost savings are a factor in the limitation of..A Survey to Assess Body and Self-Image in Individuals with Bladder Exstrophy: A Call for Psychosocial Support
Journal of Urology
Feb 2013
A Survey to Assess Body and Self-Image in Individuals with Bladder Exstrophy: A Call for Psychosocial Support
Purpose: Although research conducted on patients with urological conditions has indicated that functional limitations, pain, limited mobility, and social restrictions can impact self-image, the influence of visibility of the condition has not been examined. The current study aims to assess body image and self-image in..The Need for Additional Procedures in Patients Undergoing Proximal Hypospadias Repairs As Reported in the Pediatric Health Information System Database
Journal of Urology
Feb 2013
The Need for Additional Procedures in Patients Undergoing Proximal Hypospadias Repairs As Reported in the Pediatric Health Information System Database
Purpose: Using administrative data from freestanding children’s hospitals in the United States, we sought to characterize the frequency and type of additional procedures required in patients undergoing proximal hypospadias repair among a larger cohort than published case series across multiple surgeons and..Reproducibility and Reliability of Semen Analyses in Youths at Risk for Infertility
Journal of Urology
Feb 2013
Reproducibility and Reliability of Semen Analyses in Youths at Risk for Infertility
Purpose: There is little normative data on semen analyses in youths at risk for, but who do not present with, infertility. Standard practice amongst infertility specialists includes evaluation of two separate semen samples given the degree of within-subject variability. We hypothesize that males transitioning from..Impact of clinical and histopathological parameters on disease-specific survival in patients with collecting duct renal cell carcinoma – Development of a disease-specific risk-model
Journal of Urology
Feb 2013
Impact of clinical and histopathological parameters on disease-specific survival in patients with collecting duct renal cell carcinoma – Development of a disease-specific risk-model
Purpose: Collecting duct renal cell carcinoma is a rare and aggressive histological subtype of renal cell carcinoma. Since only few studies have evaluated oncological prognosis of these patients based on clinical and pathological parameters, we aimed to assess parameters prognostic for disease-specific mortality...Trends in utilization and outcomes for percutaneous nephrolithotomy in the United States
Journal of Urology
Feb 2013
Trends in utilization and outcomes for percutaneous nephrolithotomy in the United States
Purpose: In this study we investigate recent trends in utilization and perioperative outcomes for percutaneous nephrolithotomy (PCNL) in the United States using a population-based cohort. Materials and Methods: Patients undergoing PCNL between 1999-2009 from the Nationwide Inpatient Sample were obtained. A weighted..Urodynamic evaluation: can it prevent the need for surgical intervention in women with apparent pure stress urinary incontinence?
BJU International
Feb 2013
Urodynamic evaluation: can it prevent the need for surgical intervention in women with apparent pure stress urinary incontinence?
Objectives: To identify how many patients with symptoms of pure stress urinary incontinence (SUI) do not require any surgical treatment on the basis of urodynamics (UDS) and how many patients still do not require surgery 1 year after UDS. To assess the outcomes of these patients at 12-month follow-up. Patients and..Tamm-Horsfall protein-associated nucleotides in patients with interstitial cystitis
BJU International
Feb 2013
Tamm-Horsfall protein-associated nucleotides in patients with interstitial cystitis
What's known on the subject? and What does the study add? The nucleotides associated with Tamm-Horsfall protein (THP) identified in this study are 2′(3′) isomers, which are uncommon and very little is known about their biochemical pathway and role in interstitial cystitis (IC). The current study provides additional..Posterior tibial nerve vs. parasacral transcutaneous neuromodulation in the treatment of overactive bladder in children
Journal of Urology
Feb 2013
Posterior tibial nerve vs. parasacral transcutaneous neuromodulation in the treatment of overactive bladder in children
Objective: Parasacral TENS and PTNS have emerged as effective methods to treat overactive bladder in children. To the best of our knowledge, however, no study has compared the two methods. The objective of this study is to evaluate the results of parasacral TENS and PTNS in children with OAB. Materials and methods:..Botulinum Toxin A Detrusor Injections Reduce Postsynaptic Muscular M2, M3, P2X2, and P2X3 Receptors in Children and Adolescents Who Have Neurogenic Detrusor Overactivity: A Single-blind Study
Urology
Feb 2013
Botulinum Toxin A Detrusor Injections Reduce Postsynaptic Muscular M2, M3, P2X2, and P2X3 Receptors in Children and Adolescents Who Have Neurogenic Detrusor Overactivity: A Single-blind Study
Objective: To analyze the effect of OnabotulinumtoxinA detrusor injections on postsynaptic muscular receptors in children and adolescents with neurogenic detrusor overactivity. Materials and Methods: A bladder augmentation became necessary in 10 children and adolescents (7 males, 3 females; median age, 12 years) who..Medium-term Outcomes of Active Surveillance for Localised Prostate Cancer
European Urology
Feb 2013
Medium-term Outcomes of Active Surveillance for Localised Prostate Cancer
Background: Active surveillance (AS) aims to allow men with favourable-risk, localised prostate cancer to avoid unnecessary treatment. Objective: To describe the clinical outcomes of a prospective study of AS. Design, setting, and participants: A single-centre, prospective cohort study. Eligibility criteria included..Topography of Lymph Node Metastases in Prostate Cancer Patients Undergoing Radical Prostatectomy and Extended Lymphadenectomy: Results of a Combined Molecular and Histopathologic Mapping Study
European Urology
Feb 2013
Topography of Lymph Node Metastases in Prostate Cancer Patients Undergoing Radical Prostatectomy and Extended Lymphadenectomy: Results of a Combined Molecular and Histopathologic Mapping Study
Background: To determine the anatomic extent of pelvic lymph node dissection (PLND) in prostate cancer (PCa) patients at the time of radical prostatectomy (RP), knowledge about the topography of lymph node (LN) metastases is required. Objective: Because small-volume LN metastases may be missed by standard..Diagnostic accuracy of renal pelvic dilatation for detecting surgically managed ureteropelvic junction obstruction
Journal of Urology
Feb 2013
Diagnostic accuracy of renal pelvic dilatation for detecting surgically managed ureteropelvic junction obstruction
Purpose: The aim of this study was to evaluate the diagnostic accuracy of renal pelvic dilatation (RPD) for detecting infants with antenatal hydronephrosis (AHN) who will need surgical intervention for ureteropelvic junction obstruction (UPJO) during follow-up. Patients and Methods: Between 1999 and 2010, 371 neonates..Is There A Role For Prophylactic Antibiotics After Stented Hypospadias Repair?
Journal of Urology
Feb 2013
Is There A Role For Prophylactic Antibiotics After Stented Hypospadias Repair?
Introduction: Data on prophylactic oral antibiotics (POA) use in stented hypospadias repair is lacking. Herein we evaluate the role of POA in preventing symptomatic urinary tract infections (UTI) in this population. Materials and Methods: We reviewed consecutive patients (September 2009 – January 2012) undergoing..Prevalence of Urinary Tract Infections and Vesicoureteral Reflux Amongst Children with Lower Urinary Tract Dysfunction
Journal of Urology
Feb 2013
Prevalence of Urinary Tract Infections and Vesicoureteral Reflux Amongst Children with Lower Urinary Tract Dysfunction
Purpose: LUT dysfunction is a common pediatric urologic problem and often is associated with UTIs. We sought to determine the prevalence of history of UTI in children with LUT dysfunction and its association, if any, with gender, bowel dysfunction, VUR, and specific LUT conditions. Methods: We retrospectively reviewed..Comparison of Semen Analyses amongst Youths with a History of Cryptorchidism or Varicocele
Journal of Urology
Feb 2013
Comparison of Semen Analyses amongst Youths with a History of Cryptorchidism or Varicocele
Purpose: We aimed to determine the relative semen quality of youths with a diagnosis of cryptorchidism (UDT) or varicocele (Vx), as a surrogate for ultimate paternity potential. We hypothesized that youths with a Vx would have a lower risk of subfertility, based on semen analysis (SA), than their counterparts with..PROGENSA®PCA3 molecular urine test as a predictor of repeat prostate biopsy outcome in men with previous negative biopsies: A prospective multicenter clinical study
Journal of Urology
Feb 2013
PROGENSA®PCA3 molecular urine test as a predictor of repeat prostate biopsy outcome in men with previous negative biopsies: A prospective multicenter clinical study
Purpose: To evaluate the clinical utility of the PROGENSA PCA3 Assay for the prediction of repeat prostate biopsy outcome. Materials and Methods: Men with at least one prior negative prostate biopsy who, based upon best clinical judgment, were scheduled for repeat prostate biopsy were enrolled at 14 centers. Whole..Transplanting into a Diverted System: Is it Safe in Children?
Journal of Urology
Feb 2013
Transplanting into a Diverted System: Is it Safe in Children?
Purpose: Historically surgeons caring for children with urinary diversions for bladder outlet obstruction routinely undiverted the child prior to renal transplant. We review the outcomes of patients undergoing kidney transplantation with and without diversion. We hypothesize that patients transplanted into a diverted..Size of Urogenital Hiatus as a Potential Risk Factor for Emptying Disorders After Pelvic Prolapse Repair
Journal of Urology
Feb 2013
Size of Urogenital Hiatus as a Potential Risk Factor for Emptying Disorders After Pelvic Prolapse Repair
Purpose: The objective of our study was to correlate the size of urogenital hiatus and levator ani contraction strength with early postoperative emptying disorders and to determine if postoperative emptying disorders can be predicted prior to anti-incontinence procedures and pelvic organ prolapse (POP) repair. Material..Incidence And Pathologic Features Of Prostate Cancer Detected On Transperineal Template-Guided Mapping Biopsy Following Negative Transrectal Ultrasound-Guided Biopsy
Journal of Urology
Feb 2013
Incidence And Pathologic Features Of Prostate Cancer Detected On Transperineal Template-Guided Mapping Biopsy Following Negative Transrectal Ultrasound-Guided Biopsy
Purpose: To determine the incidence of cancer detection with transperineal template-guided mapping biopsy (TTMB) of the prostate in patients having at least one previously negative transrectal ultrasound-guided (TRUS) biopsy. Materials and Methods: From January 2005 – January 2012, 485 patients in our clinical database..Does Timing of Cytoreductive Nephrectomy Impact Patient Survival With Metastatic Renal Cell Carcinoma in the Tyrosine Kinase Inhibitor Era? A Multi-institutional Study
Urology
Feb 2013
Does Timing of Cytoreductive Nephrectomy Impact Patient Survival With Metastatic Renal Cell Carcinoma in the Tyrosine Kinase Inhibitor Era? A Multi-institutional Study
Objective To compare outcomes of metastatic renal cell carcinoma (mRCC) patients who underwent primary cytoreductive nephrectomy (CRN), followed by adjuvant sunitinib therapy, vs those who underwent primary sunitinib therapy before planned CRN. Methods This was a multi-institutional retrospective analysis of 35 mRCC..Manual Repositioning of Intra-atrial Kidney Cancer Tumor Thrombus: A Technique Reducing the Need for Cardiopulmonary Bypass
Urology
Feb 2013
Manual Repositioning of Intra-atrial Kidney Cancer Tumor Thrombus: A Technique Reducing the Need for Cardiopulmonary Bypass
Objective: To describe a feasible surgical technique for patients with renal cell carcinoma associated with a supradiaphragmatic tumor thrombus that avoids cardiopulmonary bypass procedure. Materials and Methods: From 2004 to 2009, 4 patients with a right kidney tumor and tumor thrombus above the diaphragm (pT3c)..Effect of Microbubble-enhanced Ultrasound on Prostate Permeability: A Potential Therapeutic Method for Prostate Disease
Urology
Feb 2013
Effect of Microbubble-enhanced Ultrasound on Prostate Permeability: A Potential Therapeutic Method for Prostate Disease
Objective: To explore the effect of microbubble-enhanced therapeutic ultrasound (MEUS) on prostate permeability and the blood-prostate barrier. Methods: Experimental rabbits were assigned to 5 separate groups; the MEUS group, the MEUS 24-hour group, and the 3 control groups. A therapeutic ultrasound device was used to..GreenLight XPS 180W vs HPS 120W Laser Therapy for Benign Prostate Hyperplasia: A Prospective Comparative Analysis After 200 Cases in a Single-center Study
Urology
Feb 2013
GreenLight XPS 180W vs HPS 120W Laser Therapy for Benign Prostate Hyperplasia: A Prospective Comparative Analysis After 200 Cases in a Single-center Study
Objective: To evaluate the safety, efficacy, and short-term outcomes of the new GreenLight XPS (GL-XPS) 180W laser system (AMS, Minnetonka, MI) in comparison to the former generation GL-HPS 120W system for the treatment of benign prostatic hyperplasia (BPH) in a prospective nonrandomized single-center study. Methods:..Patterns and Predictors of Amelioration of Genitourinary Toxicity After High-dose Intensity-modulated Radiation Therapy for Localized Prostate Cancer: Implications for Defining Postradiotherapy Urinary Toxicity
European Urology
Feb 2013
Patterns and Predictors of Amelioration of Genitourinary Toxicity After High-dose Intensity-modulated Radiation Therapy for Localized Prostate Cancer: Implications for Defining Postradiotherapy Urinary Toxicity
Background: Treatment-related toxicity and quality of life (QoL) considerations are important when counseling patients with localized prostate cancer (PCa). Objective: To determine the incidence and longitudinal pattern of late genitourinary (GU) toxicity and QoL after high-dose, intensity-modulated radiotherapy..Evolution and outcomes of 3 MHz High intensity focused ultrasound therapy for localized prostate cancer over 15 years
Journal of Urology
Feb 2013
Evolution and outcomes of 3 MHz High intensity focused ultrasound therapy for localized prostate cancer over 15 years
Purpose: To describe the long-term cancer control and morbidity of high intensity focused ultrasound (HIFU) with neoadjuvant transurethral resection of the prostate (TURP), the risk of metastatic induction by TURP and the evolution of HIFU application and technology over time. Patients and Methods: Prospective..Intraoperative frozen section of the prostate reduces positive margin rates while ensuring nerve-sparing procedure during radical prostatectomy
Journal of Urology
Feb 2013
Intraoperative frozen section of the prostate reduces positive margin rates while ensuring nerve-sparing procedure during radical prostatectomy
Purpose: To evaluate whether intraoperative frozen section analysis (FS) of the prostate surface might provide significant information ensuring nerve-sparing and minimizing positive margin rates. Material and Methods: Between 6/2011 and 9/2012, 236 patients treated with radical prostatectomy received intraoperative..Nine-Year Outcome and Toxicity in Patients treated with IMRT for Localized Prostate Cancer
Journal of Urology
Feb 2013
Nine-Year Outcome and Toxicity in Patients treated with IMRT for Localized Prostate Cancer
Purpose: To evaluate long-term disease control and chronic toxicities observed in patients treated with intensity-modulated radiation therapy (IMRT) for clinically localized prostate cancer. Methods/Materials: 302 patients with localized prostate cancer treated with image guided IMRT between 7/2000 and 5/2005 were..Diurnal Temperature Change is Associated with Testicular Torsion—A Nationwide Population-Based Study in Taiwan
Journal of Urology
Feb 2013
Diurnal Temperature Change is Associated with Testicular Torsion—A Nationwide Population-Based Study in Taiwan
Purpose: To investigate the association between climatic variables and testicular torsion in Taiwan. Materials and Methods: Using Taiwan’s Longitudinal Health Insurance Database, we reviewed the files of patients diagnosed with testicular torsion and given an orchiectomy or orchiopexy from January 1996 through December..Men with Low Preoperative Sexual Function May Benefit From Nerve-sparing Radical Prostatectomy
Journal of Urology
Feb 2013
Men with Low Preoperative Sexual Function May Benefit From Nerve-sparing Radical Prostatectomy
Purpose: To determine the effect of nerve-sparing RP on sexual and urinary function in men at various levels of pretreatment SF. Methods: Men within the CaPSURE database who underwent RP and had baseline and 2 year post-treatment UCLA PCI SF and UF scores were selected. Nerve-sparing was categorized as bilateral,..Androgen-deprivation Therapy in Treatment of Prostate Cancer and Risk of Myocardial Infarction and Stroke: A Nationwide Danish Population-based Cohort Study
European Urology
Feb 2013
Androgen-deprivation Therapy in Treatment of Prostate Cancer and Risk of Myocardial Infarction and Stroke: A Nationwide Danish Population-based Cohort Study
Background: Androgen-deprivation therapy (ADT) has been suggested to increase the risk for cardiovascular diseases, including myocardial infarction (MI) and stroke, but data are inconsistent. Objectives: To investigate the association between ADT and risk for MI and stroke in Danish men with prostate cancer. Design,..Androgen-deprivation Therapy and Risk for Biliary Disease in Men with Prostate Cancer
European Urology
Feb 2013
Androgen-deprivation Therapy and Risk for Biliary Disease in Men with Prostate Cancer
Background: Androgen-deprivation therapy (ADT) by either a gonadotropin-releasing hormone (GnRH) agonist or bilateral orchiectomy improves disease-related outcomes of men with prostate cancer but has a variety of adverse metabolic effects including obesity, increased abdominal girth, increased triglycerides, and..Protein Markers of Malignant Potential in Penile and Vulvar Lichen Sclerosus
Journal of Urology
Feb 2013
Protein Markers of Malignant Potential in Penile and Vulvar Lichen Sclerosus
Purpose: Lichen sclerosus (LS) is an inflammatory skin disorder affecting anogenital areas in males and females and has been associated with squamous cell carcinoma (SCC); however there is a lack of data on the role of biomarkers for the prediction of LS progression to SCC. This review focuses on early protein markers..Effect of Practice Integration between Urologists and Radiation Oncologists on Prostate Cancer Treatment Patterns
Journal of Urology
Feb 2013
Effect of Practice Integration between Urologists and Radiation Oncologists on Prostate Cancer Treatment Patterns
Purpose: National attention has focused on whether urology-radiation oncology practice integration – known as integrated prostate cancer centers (IPCCs) – contributes to use of intensity-modulated radiation therapy (IMRT), a common and expensive treatment for prostate cancer. Methods: We examined prostate cancer..Low 25-OH Vitamin D Level is Associated with Benign Prostatic Enlargement (BPE)
Journal of Urology
Feb 2013
Low 25-OH Vitamin D Level is Associated with Benign Prostatic Enlargement (BPE)
Purpose: To test the hypothesis that low levels of vitamin D were associated with Benign Prostatic Enlargement (BPE). We also studied whether body composition, sex hormones, serum SHBG, albumin corrected serum calcium, adiponectin and lipid statuses were associated with BPE. Materials and Methods: 184 representative..Testosterone Replacement Therapy in Patients with Prostate Cancer After Radical Prostatectomy
Journal of Urology
Feb 2013
Testosterone Replacement Therapy in Patients with Prostate Cancer After Radical Prostatectomy
Purpose: Testosterone replacement therapy in men with prostate cancer is controversial, with concern that testosterone can stimulate cancer growth. We evaluated the safety and efficacy of testosterone in hypogonadal men with prostate cancer treated with radical prostatectomy. Materials and Methods: Review of 103..Impact of Statin Use on Oncological Outcomes of Patients with Urothelial Carcinoma of the Bladder Treated With Radical Cystectomy
Journal of Urology
Feb 2013
Impact of Statin Use on Oncological Outcomes of Patients with Urothelial Carcinoma of the Bladder Treated With Radical Cystectomy
Purpose: Statins are cholesterol-lowering agents used to prevent cardiovascular disease. Evidence suggests a dichotomous effect of statins with both cancer-inhibiting and -promoting properties. To date, the effect of statin use on prognosis in muscle-invasive urothelial carcinoma of the bladder (UCB) remains..Acquired Undescended Testis: Long-Term Volume after Orchidopexy at Diagnosis
Journal of Urology
Feb 2013
Acquired Undescended Testis: Long-Term Volume after Orchidopexy at Diagnosis
In order to study the long-term outcome of orchidopexy at diagnosis for acquired undescended testes, we used ultrasound to determine the long-term testicular volume. Patients who had undergone orchidopexy for acquired undescended testis at diagnosis were recruited to assess testicular volume. Testis volume was..Ejaculatory Responses are Inhibited by a New Chemical Entity, DA-8031, in Preclinical Rodent Models of Ejaculation
Urology
Feb 2013
Ejaculatory Responses are Inhibited by a New Chemical Entity, DA-8031, in Preclinical Rodent Models of Ejaculation
Objective: To investigate the efficacy of DA-8031, a novel compound for the treatment of premature ejaculation (PE), we performed in vivo pharmacological studies using 2 preclinical animal models, electrical stimulation of sensory branch of pudendal nerve (SBPdn) and para-chloroamphetamine (PCA)-induced ejaculation..Adolescent Xanthogranulomatous Pyelonephritis Mimicking Renal Cell Carcinoma on Urine Cytology: An Atypical Presentation
Urology
Feb 2013
Adolescent Xanthogranulomatous Pyelonephritis Mimicking Renal Cell Carcinoma on Urine Cytology: An Atypical Presentation
Xanthogranulomatous pyelonephritis (XGP) is a chronic renal inflammatory lesion that is rarely diagnosed in children. We present a case of a 16-year-old boy presenting with gross hematuria and a lack of laboratory and radiographic findings for XGP who was suspected of having renal cell carcinoma on urine cytology. Left..Fiber-substituted Conditionally Replicating Adenovirus Ad5F35 Induces Oncolysis of Human Bladder Cancer Cells in In Vitro Analysis
Urology
Feb 2013
Fiber-substituted Conditionally Replicating Adenovirus Ad5F35 Induces Oncolysis of Human Bladder Cancer Cells in In Vitro Analysis
Objective: To assess the oncolytic effect of fiber-substituted conditionally replicating adenovirus type 5 (Ad5) F35 vector on human bladder cancer cell lines such as 253J, 5637, KK-47, T24, TCCSUP, and UMUC-3 cells. Materials and Methods: Ad5F35 and Ad5 conditionally replicating adenovirus vectors containing the E1..Does Suspicion of Prostate Cancer on Integrated T2 and Diffusion-weighted MRI Predict More Adverse Pathology on Radical Prostatectomy?
Urology
Feb 2013
Does Suspicion of Prostate Cancer on Integrated T2 and Diffusion-weighted MRI Predict More Adverse Pathology on Radical Prostatectomy?
Objective: To determine whether suspicion for tumor on prostate MRI incorporating T2-weighted imaging (T2-WI) and diffusion-weighted imaging (DWI) predicts more adverse pathology on radical prostatectomy (RP). Methods: From 2007 to 2009, 154 patients underwent 1.5 Tesla pelvic-phased-array magnetic resonance imaging..Illness Uncertainty and Quality of Life of Patients with Small Renal Tumors Undergoing Watchful Waiting: A 2-year Prospective Study
European Urology
Feb 2013
Illness Uncertainty and Quality of Life of Patients with Small Renal Tumors Undergoing Watchful Waiting: A 2-year Prospective Study
Background: Few studies have examined factors associated with the quality of life (QOL) of patients with renal tumors. Illness uncertainty may influence QOL. Objective: To prospectively examine the influence of uncertainty on general and cancer-specific QOL and distress in patients undergoing watchful waiting (WW) for..Is an Initial Saturation Prostate Biopsy Scheme Better than an Extended Scheme for Detection of Prostate Cancer? A Systematic Review and Meta-analysis
European Urology
Feb 2013
Is an Initial Saturation Prostate Biopsy Scheme Better than an Extended Scheme for Detection of Prostate Cancer? A Systematic Review and Meta-analysis
Context: The optimal initial prostate biopsy core number is still an issue with many unanswered questions and significant controversy. Objective: To compare diagnostic values of initial saturation prostate biopsy scheme and extended scheme with respect to prostate-specific antigen (PSA) levels, prostate volume (PV),..Factors Indicating Renal Injury in Pediatric Bilateral Ureteropelvic-junction Obstruction
Urology
Feb 2013
Factors Indicating Renal Injury in Pediatric Bilateral Ureteropelvic-junction Obstruction
Objective: To analyze the factors indicating renal injury in patients with bilateral ureteropelvic-junction obstruction (UPJO). Methods: We investigated 26 patients, 35 kidney units (KUs), who were diagnosed with bilateral UPJO and underwent unilateral or bilateral pyeloplasty between January 2000 and December 2011...Laparoendoscopic Single-site Partial Nephrectomy: A Multi-institutional Outcome Analysis
European Urology
Feb 2013
Laparoendoscopic Single-site Partial Nephrectomy: A Multi-institutional Outcome Analysis
Background: Laparoendoscopic single-site surgery (LESS) has been developed in an attempt to further reduce the surgical trauma associated with conventional laparoscopy. Partial nephrectomy (PN) represents a challenging indication for LESS. Objective: To report a large multi-institutional series of LESS-PN and to..Kidney Stone Size and Hounsfield Units Predict Successful Shockwave Lithotripsy in Children
Urology
Feb 2013
Kidney Stone Size and Hounsfield Units Predict Successful Shockwave Lithotripsy in Children
Objective: To define the preoperative kidney and stones characteristics on noncontrast-enhanced computed tomography that affect the success of extracorporeal shockwave lithotripsy (SWL) for treatment of renal calculi in pediatric patients. Materials and Methods: From 2005 to 2011, 57 children (age <16 years) with..Potential Consequences of Low Biopsy Core Number in Selection of Patients With Prostate Cancer for Current Active Surveillance Protocols
Urology
Feb 2013
Potential Consequences of Low Biopsy Core Number in Selection of Patients With Prostate Cancer for Current Active Surveillance Protocols
Objective: To compare the performance of the Epstein criteria and the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria in the identification of patients eligible for active surveillance (AS) but treated with radical prostatectomy. Materials and Methods: We evaluated the baseline..Predictors of the use of orthotopic bladder reconstruction after radical cystectomy for bladder cancer: data from a pilot study of 1756 cases 2004–2011
BJU International
Feb 2013
Predictors of the use of orthotopic bladder reconstruction after radical cystectomy for bladder cancer: data from a pilot study of 1756 cases 2004–2011
What's known on the subject? and What does the study add? How often orthotopic reconstruction should be used after radical cystectomy is uncertain. Male sex, younger age, affluence, white ethnicity and treatment in specialist hospitals may be associated with more frequent use. More evidence about the level and likely..Learning Curve of Robotic Assisted Pyeloplasty for Pediatric Urology Fellows
Journal of Urology
Feb 2013
Learning Curve of Robotic Assisted Pyeloplasty for Pediatric Urology Fellows
Purpose: Little is known about the learning curve of robotic surgery for surgeons-in-training. We hypothesized that pediatric urology fellows could attain proficiency in robotic pyeloplasty, defined as an operative time equivalent to that of an experienced robotic surgeon, within the two-year time frame of fellowship...Pathological response to neoadjuvant chemotherapy for muscle-invasive micropapillary bladder cancer
BJU International
Feb 2013
Pathological response to neoadjuvant chemotherapy for muscle-invasive micropapillary bladder cancer
What's known on the subject? and What does the study add? Micropapillary bladder cancer is a high grade variant with poor prognosis. There is no consensus about patients with micropapillary bladder cancer receiving neoadjuvant chemotherapy, but many suggest that radical cystectomy should not be delayed. Data from this..Fibulin-1 is down-regulated through promoter hypermethylation and suppresses tumor progression in renal cell carcinoma
Journal of Urology
Feb 2013
Fibulin-1 is down-regulated through promoter hypermethylation and suppresses tumor progression in renal cell carcinoma
Purpose Renal cell carcinoma (RCC) is one of the most common cancers worldwide, but the molecular mechanisms that underlie RCC are not fully understood. Fibulin-1, a multi-functional extracellular matrix protein, has been demonstrated to be involved in many kind of cancer, while its function in RCC is unclear. So here..Prospective Evaluation of Sacral Nerve Modulation in Children with Validated Questionnaires
Journal of Urology
Feb 2013
Prospective Evaluation of Sacral Nerve Modulation in Children with Validated Questionnaires
Purpose: Sacral neuromodulation for refractory urinary dysfunction in pediatrics has shown promising results. We prospectively evaluated patients undergoing sacral neuromodulation using validated quality of life (QOL) and bladder dysfunction questionnaires. Materials and Methods: All patients were prospectively..Detection of bladder urothelial carcinomas using in vivo non-contact ultraviolet-excited autofluorescence measurements converted into simple colour-coded images: a feasibility study
Journal of Urology
Feb 2013
Detection of bladder urothelial carcinomas using in vivo non-contact ultraviolet-excited autofluorescence measurements converted into simple colour-coded images: a feasibility study
Purpose: One difficulty in non-muscle-invasive bladder cancers (NMIBCs) is the diagnosis of flat and small lesions during white-light cystoscopy. To assess the use of a prototype that takes ultraviolet laser-induced autofluorescence measurements (AM) for the endoscopic detection of NMIBCs. Material and Methods: We..Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a Marker for Acute Kidney Injury in Kidney Surgery Patients
Journal of Urology
Feb 2013
Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a Marker for Acute Kidney Injury in Kidney Surgery Patients
Purpose: Evaluate uNGAL as a marker for AKI in patients undergoing PN to identify the preoperative clinical features and surgical factors during PN that are associated with renal injury as measured by increased uNGAL levels compared to controls. Methods: Using RN and thoracic surgery patients as control groups, we..Male circumcision decreases penile sensitivity as measured in a large cohort
BJU International
Feb 2013
Male circumcision decreases penile sensitivity as measured in a large cohort
What's known on the subject? and What does the study add? The sensitivity of the foreskin and its importance in erogenous sensitivity is widely debated and controversial. This is part of the actual public debate on circumcision for non-medical reason. Today some studies on the effect of circumcision on sexual function..Obesity is associated with worse outcomes in patients with T1 high grade urothelial carcinoma of the bladder
Journal of Urology
Feb 2013
Obesity is associated with worse outcomes in patients with T1 high grade urothelial carcinoma of the bladder
Purpose: To our knowledge, the impact of body mass index (BMI) on oncological outcomes in non-muscle invasive bladder cancer (NMIBC) has not been evaluated. We hypothesized that higher BMI is associated with worse outcomes in patients with clinical primary T1 high-grade (HG) UCB. Material and methods: We..Bother and distress associated with Peyronie’s disease: validation of the Peyronie’s Disease Questionnaire (PDQ)
Journal of Urology
Feb 2013
Bother and distress associated with Peyronie’s disease: validation of the Peyronie’s Disease Questionnaire (PDQ)
Purpose: To validate the Peyronie’s Disease Questionnaire (PDQ), a 15-question self-reported survey, measuring the impact and severity of Peyronie’s disease (PD) symptoms in 3 domains: 1) Psychological and Physical Symptoms, 2) Penile Pain, and 3) Symptom Bother. Materials and Methods: Baseline data from two phase 3..Predictors of secondary surgery after hypospadias repair: a population-based analysis of 5,000 patients
Journal of Urology
Feb 2013
Predictors of secondary surgery after hypospadias repair: a population-based analysis of 5,000 patients
Purpose: Literature on secondary surgery after hypospadias repair is limited. Risk factors for secondary surgery were determined via a population-based approach. Materials and Methods: We utilized a hospital consortium database to identify a population that underwent hypospadias repair between 2009 and 2010...The distal left-sided Malone antegrade continence enema (MACE): Is it better?
Journal of Urology
Feb 2013
The distal left-sided Malone antegrade continence enema (MACE): Is it better?
Purpose: The Malone antegrade continence enema (MACE) is utilized for refractory fecal dysfunction in the pediatric neuropathic population. While various MACE locations along the colon have been described, the optimal location for achieving efficient enemas remains unknown. We reviewed our experience of the MACE..The Fate of the Complete Female Epispadias and Female Exstrophy Bladder: Is There A Difference?
Journal of Urology
Feb 2013
The Fate of the Complete Female Epispadias and Female Exstrophy Bladder: Is There A Difference?
Purpose: Complete female epispadias (CFE), occurring much more rarely than classic bladder exstrophy (CBE) in females, is thought to offer a more benign clinical course. The authors hypothesize that patients with CFE are more likely to have larger bladder capacities (BC) and achieve voiding continence than females with..A Two-Stage Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Associated with Development of Urinary Symptoms Following Radiotherapy for Prostate Cancer
Journal of Urology
Feb 2013
A Two-Stage Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms Associated with Development of Urinary Symptoms Following Radiotherapy for Prostate Cancer
Purpose: To identify SNPs associated with change in American Urological Association Symptom Score (AUASS) following radiotherapy (RT) for prostate cancer. Materials and Methods: 723 patients treated with brachytherapy with or without external beam radiation therapy were assessed at baseline and annually after RT using..Impact of Adjuvant Radiation Therapy on Urinary Continence Recovery After Radical Prostatectomy
European Urology
Feb 2013
Impact of Adjuvant Radiation Therapy on Urinary Continence Recovery After Radical Prostatectomy
Background: Little is known about the impact of adjuvant radiation therapy (aRT) after radical prostatectomy (RP) on urinary continence (UC). Objective: To evaluate the impact of aRT on UC recovery in patients with unfavourable pathologic characteristics. Design, setting, and participants: The study included 361..Long-term Prostate-specific Antigen Velocity in Improved Classification of Prostate Cancer Risk and Mortality
European Urology
Feb 2013
Long-term Prostate-specific Antigen Velocity in Improved Classification of Prostate Cancer Risk and Mortality
Background: It remains unclear whether adding long-term prostate-specific antigen velocity (PSAV) to baseline PSA values improves classification of prostate cancer (PCa) risk and mortality in the general population. Objective: To determine whether long-term PSAV improves classification of PCa risk and mortality in the..Comparative Effectiveness and Safety of Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction: A Systematic Review and Network Meta-analysis
European Urology
Jan 2013
Comparative Effectiveness and Safety of Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction: A Systematic Review and Network Meta-analysis
Context: Phosphodiesterase type 5 inhibitors (PDE5-Is) are currently the first-line therapy for erectile dysfunction (ED), but available studies investigating the comparative effects of different PDE5-Is are limited. Objective: To compare the efficacy and safety of different classes of oral PDE5-Is for ED. Evidence..Interventions for impaired bladders in paediatric renal transplant recipients with lower urinary tract dysfunction
Transplant International
Jan 2013
Interventions for impaired bladders in paediatric renal transplant recipients with lower urinary tract dysfunction
Dysfunctional bladders in paediatric patients were thought to be a contraindication for renal transplantation, but advances in surgical techniques have meant that surgical correction can allow safe transplantation. This study compares the outcomes of renal transplantation for different interventions, and the timing of..Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy
BJU International
Jan 2013
Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy
What's known on the subject? and What does the study add? It is known that a prostate cancer gene 3 (PCA3) urine assay is superior to serum PSA level or PSA-related indices for predicting a positive biopsy result in European and US men. This is the first report on PCA3 in a large cohort of Japanese men. The diagnostic..Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to standardize protocols?
BJU International
Jan 2013
Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to standardize protocols?
What's known on the subject? and What does the study add?The topic of radiation safety has been hotly debated not only in the mainstream media, but also in the urological literature. Radiation exposure has been examined in urological diseases such as testicular cancer and urinary stone disease, with resultant..Current status of long-term indwelling urinary catheter management by visiting nurses
International Journal of Urological Nursing
Jan 2013
Current status of long-term indwelling urinary catheter management by visiting nurses
Patients with indwelling catheters at home are more likely to receive home-visit nursing care. However, the condition of patients with indwelling catheters among those receiving home-visit nursing care, as well as the actual status of catheter management practised by visiting nurses, has not been studied. The aim of..Place of Residence and Primary Treatment of Prostate Cancer: Examining Trends in Rural and Nonrural Areas in Wisconsin
Urology
Jan 2013
Place of Residence and Primary Treatment of Prostate Cancer: Examining Trends in Rural and Nonrural Areas in Wisconsin
Objective: To determine whether rural residents were at a disadvantage compared with urban residents with regard to the receipt of curative therapy for prostate cancer. Materials and Methods: Using the Breast and Prostate Cancer Data Quality and Patterns of Care Study II, patients with prostate cancer who were..The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score
Urology
Jan 2013
The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score
Objective: To investigate the total prostate-specific antigen (tPSA), free PSA (fPSA), and free/total PSA (fPSA/tPSA) ratio in patients with liver cirrhosis (LC) according to the severity of hepatic insufficiency. Methods: Eighty-two male patients with LC were studied. The severity of liver disease was categorized by..Shock Wave Lithotripsy of Vesical Stones in Patients With Infravesical Obstruction: An Underused Noninvasive Approach
Urology
Jan 2013
Shock Wave Lithotripsy of Vesical Stones in Patients With Infravesical Obstruction: An Underused Noninvasive Approach
Objective: To evaluate the effectiveness and safety of shock wave lithotripsy in the management vesical stones in patients with infravesical obstruction. Materials and Methods: From March 2007 to April 2010, 59 male patients with infravesical obstruction were treated using the Dornier Compact Delta II Lithotriptor for..Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review
Urology
Jan 2013
Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review
Both clinical and preclinical studies have mostly shown beneficial effects for Phosphodiesterase-5 (PDE-5) inhibitors in the treatment of lower urinary tract symptoms. Molecular studies have consistently shown abundant PDE-5 expression in bladder smooth muscle. Data concerning urethral PDE-5 expression have been..A New Method to Quantify Male Pelvic Floor Displacement From 2D Transperineal Ultrasound Images
Urology
Jan 2013
A New Method to Quantify Male Pelvic Floor Displacement From 2D Transperineal Ultrasound Images
Objective: To develop a method to quantify displacement of pelvic structures during contraction of the pelvic floor muscles from transperineal ultrasound images in men and investigate the reliability of the method between days. Methods: Ten healthy male volunteers (aged 28–41 years) attended 2 separate data collection..Transurethral Laser Surgery for Benign Prostate Hyperplasia in Octogenarians: Safety and Outcomes
Urology
Jan 2013
Transurethral Laser Surgery for Benign Prostate Hyperplasia in Octogenarians: Safety and Outcomes
Objective: To evaluate the morbidity and perioperative outcome of different laser prostate techniques among octogenarians. Methods: We performed a retrospective review of our prospectively maintained laser prostate surgery database between 1998 and 2012. We identified 264 octogenarians (16.5%) who underwent laser..Prevalence of ST131 Among Fluoroquinolone-resistant Escherichia coli Obtained From Rectal Swabs Before Transrectal Prostate Biopsy
Urology
Jan 2013
Prevalence of ST131 Among Fluoroquinolone-resistant Escherichia coli Obtained From Rectal Swabs Before Transrectal Prostate Biopsy
Objective: To identify the prevalence and characteristics of fluoroquinolone-resistant (FQ-R) Escherichia coli ST131 isolates in men undergoing ultrasound-guided transrectal prostate biopsy (TPB). Materials and Methods: Twenty-seven FQ-R E coli isolates from rectal swabs from 136 men undergoing TPB at 3 institutions in..Differing risk of cancer death among patients with lymph node metastasis after radical prostatectomy and pelvic lymph node dissection: identification of risk categories according to number of positive nodes and Gleason score
BJU International
Jan 2013
Differing risk of cancer death among patients with lymph node metastasis after radical prostatectomy and pelvic lymph node dissection: identification of risk categories according to number of positive nodes and Gleason score
What's known on the subject? and What does the study add? Lymph node (LN) status is one of the most important prognostic variables in patients undergoing radical prostatectomy, but not all patients with node-positive PCa are at the same risk of recurrence and cancer-specific death. In this study we evaluated the role..A novel tool to assess the risk of urinary incontinence after nerve-sparing radical prostatectomy
BJU International
Jan 2013
A novel tool to assess the risk of urinary incontinence after nerve-sparing radical prostatectomy
What's known on the subject? and What does the study add? Urinary incontinence is one of the most important morbidities after radical prostatectomy that has detrimental effect on the postoperative quality of life. The present study provides an accurate and dynamic multivariable risk stratification tool that predicts..Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications
BJU International
Jan 2013
Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications
What's known on the subject? and What does the study add? Receipt of androgen deprivation therapy (ADT) has been associated with an increased risk of skeletal-associated complications, such as a decrease in bone mineral density and an increase in fracture risk. Many men with pre-existing health conditions receive ADT..Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non-metastatic carcinoma invading bladder muscle: results from a nationwide case–control study
BJU International
Jan 2013
Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non-metastatic carcinoma invading bladder muscle: results from a nationwide case–control study
What's known on the subject? and What does the study add? Positive surgical margin (PSM) frequency after radical cystectomy has been estimated to be 4–15%. Studies that have not distinguished between the different sites of PSM have failed to show that they are an independent prognostic factor for disease-free survival...Schwann cell-mediated delivery of glial cell line-derived neurotrophic factor restores erectile function after cavernous nerve injury
International Journal of Urology
Jan 2013
Schwann cell-mediated delivery of glial cell line-derived neurotrophic factor restores erectile function after cavernous nerve injury
Objectives: To evaluate the time-course of functional recovery after cavernous nerve injury using glial cell line-derived neurotrophic factor-transduced Schwann cell-seeded silicon tubes. Methods: Sections of the cavernous nerves were excised bilaterally (5 mm), followed by immediate bilateral surgical repair. A total..Spindle cell rhabdomyosarcoma of the prostate
International Journal of Urology
Jan 2013
Spindle cell rhabdomyosarcoma of the prostate
The spindle cell rhabdomyosarcoma is a rare variant of the embryonal rhabdomyosarcoma, mostly occurring in childhood. Only a few cases are described in adults. To date, no case of the spindle cell subtype of the prostatic embryonal rhabdomyosarcoma has been published. We report on a 23-year-old man, initially..Pathological and biochemical outcomes after radical prostatectomy in men with low-risk prostate cancer meeting the Prostate Cancer International: Active Surveillance criteria
BJU International
Jan 2013
Pathological and biochemical outcomes after radical prostatectomy in men with low-risk prostate cancer meeting the Prostate Cancer International: Active Surveillance criteria
What's known on the subject? and What does the study add? Active surveillance has been widely accepted as a treatment tool for low-risk prostate cancer, and use of the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria can select smaller and less aggressive tumours in low-risk disease. The..Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer?
BJU International
Jan 2013
Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer?
What's known on the subject? and What does the study add? Urothelial carcinoma of the bladder (UCB) is more prevalent in men than women; however, in women the tumour stage is generally more advanced at the time of the diagnosis and the prognosis is worse. Possible explanations include anatomical, genetic and..Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort
BJU International
Jan 2013
Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort
What's known on the subject? and What does the study add? Family history (FH) is a major risk factor for the development of prostate cancer. The search for genetic variants has led to genome-wide association studies (GWAS), which have so far reported 47 susceptibility loci that predispose men to prostate cancer...Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer
BJU International
Jan 2013
Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer
What's known on the subject? and What does the study add? The use of MRI for prostate cancer diagnosis and staging is increasing. Indications for prostate MRI are not defined and many clinicians are unsure of how best to use MRI to aid clinical decisions. This evidence-based medicine article addresses the clinical..Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population
BJU International
Jan 2013
Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population
What's known on the subject? and What does the study add? The use of a single, elevated PSA level to screen for prostate cancer is controversial given its reported low specificity and the questionable benefits of PSA screening on prostate cancer mortality. Current guidelines in the USA recommend against screening using..Long-term critical issues in pediatric renal transplant recipients: a single-center experience
Transplant International
Dec 2012
Long-term critical issues in pediatric renal transplant recipients: a single-center experience
Data on long-term outcomes after pediatric renal transplantation (Tx) are still limited. We report on a 20-year single-center experience. Medical charts of all consecutive pediatric Tx performed between 1987 and 2007 were reviewed. Data of patients who had been transferred to adult units were extracted from the French..MicroRNAs in Kidney Disease: An Emerging Understanding
American Journal of Kidney Diseases
Dec 2012
MicroRNAs in Kidney Disease: An Emerging Understanding
MicroRNAs (miRNAs) are short noncoding RNA molecules that function by negatively regulating the expression of their target genes in a tightly controlled manner. Accumulating evidence, based in part on effects seen after miRNA overexpression and/or knockdown, points to the critical involvement of miRNAs in kidney..Removal of Dabigatran by Hemodialysis
American Journal of Kidney Diseases
Dec 2012
Removal of Dabigatran by Hemodialysis
Dabigatran is a newly available oral direct thrombin inhibitor approved for anticoagulation therapy to prevent strokes in patients with nonvalvular atrial fibrillation. Unlike warfarin, dabigatran's observed therapeutic window and minimal drug-to-drug interaction suggest that invasive laboratory testing and dose..Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study
Transplant International
Dec 2012
Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study
The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs..Effect of a High-Protein Diet on Kidney Function in Healthy Adults: Results From the OmniHeart Trial
American Journal of Kidney Diseases
Dec 2012
Effect of a High-Protein Diet on Kidney Function in Healthy Adults: Results From the OmniHeart Trial
Background: Consumption of a diet high in protein can cause glomerular hyperfiltration, a potentially maladaptive response, which may accelerate the progression of kidney disease. Study Design: An ancillary study of the OmniHeart trial, a randomized 3-period crossover feeding trial testing the effects of partial..Retinopathy and Cognitive Impairment in Adults With CKD
American Journal of Kidney Diseases
Dec 2012
Retinopathy and Cognitive Impairment in Adults With CKD
Background10:30 Retinal microvascular abnormalities have been associated with cognitive impairment, possibly serving as a marker of cerebral small-vessel disease. This relationship has not been evaluated in persons with chronic kidney disease (CKD), a condition associated with increased risk of both retinal pathology..Association Between Abnormal Myocardial Fatty Acid Metabolism and Cardiac-Derived Death Among Patients Undergoing Hemodialysis: Results From a Cohort Study in Japan
American Journal of Kidney Diseases
Dec 2012
Association Between Abnormal Myocardial Fatty Acid Metabolism and Cardiac-Derived Death Among Patients Undergoing Hemodialysis: Results From a Cohort Study in Japan
Background: Detecting myocardial ischemia in hemodialysis patients is crucial given the high incidence of silent ischemia and the high cardiovascular mortality rates. Abnormal myocardial fatty acid metabolism as determined by imaging with 123I-labeled BMIPP (β-methyl iodophenyl-pentadecanoic acid) might be associated..IgG4-Related Tubulointerstitial Nephritis With Plasma Cell–Rich Renal Arteritis
American Journal of Kidney Diseases
Dec 2012
IgG4-Related Tubulointerstitial Nephritis With Plasma Cell–Rich Renal Arteritis
Immunoglobulin G4 (IgG4)-related tubulointerstitial nephritis is a newly recognized clinicopathologic entity that may occur as an isolated renal lesion or as part of a multisystem disorder. It is characterized by plasma cell–rich interstitial nephritis with abundant IgG4-positive plasma cells and IgG-dominant..Renal Cortical Infarction Following Treatment With Sumatriptan in a Kidney Allograft Recipient
American Journal of Kidney Diseases
Dec 2012
Renal Cortical Infarction Following Treatment With Sumatriptan in a Kidney Allograft Recipient
Renal cortical infarction is a rare cause of acute kidney injury that results from inadequate blood flow to the kidney, most commonly as a consequence of thrombotic or embolic occlusion of the renal artery or profound hypoperfusion. We report the case of a 78-year-old female kidney transplant recipient who developed a..Evaluation of Hypomagnesemia: Lessons From Disorders of Tubular Transport
American Journal of Kidney Diseases
Dec 2012
Evaluation of Hypomagnesemia: Lessons From Disorders of Tubular Transport
Hypomagnesemia is a highly prevalent clinical condition affecting a large number of hospitalized patients. A decrease in systemic magnesium concentration may lead to impaired function of both neurologic and cardiovascular systems. The kidney has a pivotal role in magnesium handling by adjusting the urinary excretion of..Regional, institutional and individual factors affecting selection of minimally invasive nephroureterectomy in Japan: A national database analysis
International Journal of Urology
Dec 2012
Regional, institutional and individual factors affecting selection of minimally invasive nephroureterectomy in Japan: A national database analysis
Objectives: To reveal individual, institutional and regional factors affecting selection of minimally invasive nephroureterectomy in Japan. Methods: The Japanese Diagnosis Procedure Combination database was queried to retrieve cases of nephroureterectomy for pelvic or ureter malignancies carried out between 2007 and..Is Urinary Kidney Injury Molecule-1 a Noninvasive Marker for Renal Scarring in Children With Vesicoureteral Reflux?
Urology
Nov 2012
Is Urinary Kidney Injury Molecule-1 a Noninvasive Marker for Renal Scarring in Children With Vesicoureteral Reflux?
Objective: To examine whether (1) levels of urinary kidney injury molecule-1 (KIM-1), a transmembrane protein and biomarker for renal tubular damage, increase in children with of vesicoureteral reflux (VUR), and (2) if KIM-1 predicts the grade of renal scarring in children with VUR. Methods: The study included 59 VUR..Needles as Urethral Foreign Body in a Child: Successful Removal Using a New Method With a Laparoscopic Needle Holder
Urology
Nov 2012
Needles as Urethral Foreign Body in a Child: Successful Removal Using a New Method With a Laparoscopic Needle Holder
Self-inserted foreign bodies in the lower urinary tract are rare among children. The treatment of foreign bodies in the urethra is determined by their type, size, location, shape, and mobility. We describe here a 13-year-old boy who had self-inserted a needle into his urethra out of curiosity. Initial attempts to..Effect of Tamsulosin on Bladder Microcirculation in Rat Model of Bladder Outlet Obstruction Using Pencil Lens Charge-coupled Device Microscopy System
Urology
Nov 2012
Effect of Tamsulosin on Bladder Microcirculation in Rat Model of Bladder Outlet Obstruction Using Pencil Lens Charge-coupled Device Microscopy System
Objective: To determine the effect of tamsulosin hydrochloride on blood flow in the submucosal capillaries of the bladder (SCB) in a rat model of bladder outlet obstruction (BOO) using a pencil lens charge-coupled device microscopy system. Materials and Methods: BOO was established in rats by partial ligature of the..Transvaginal Mesh Kits—How “Serious” Are the Complications and Are They Reversible?
Urology
Nov 2012
Transvaginal Mesh Kits—How “Serious” Are the Complications and Are They Reversible?
Objective: To review the merit of the U.S. Food and Drug Administration-issued warnings on the use of transvaginal mesh in women with pelvic organ prolapse because of escalating complications. Materials and Methods: On institutional review board approval, we reviewed the data from 2 tertiary institutions managing..Adrenoceptor Function and Expression in Bladder Urothelium and Lamina Propria
Urology
Nov 2012
Adrenoceptor Function and Expression in Bladder Urothelium and Lamina Propria
Objective: To investigate the role of adrenoceptor subtypes in regulating the spontaneous contractile activity of the inner lining of the urinary bladder (urothelium/lamina propria). Materials and Methods: The responses of isolated strips of porcine urothelium/lamina propria to noradrenaline, phenylephrine, and..Symptomatic Bilateral Delayed Partial Ureteral Obstruction After Bilateral Endoscopic Correction of Vesicoureteral Reflux With Dextranomer/Hyaluronic Acid Polymer
Urology
Nov 2012
Symptomatic Bilateral Delayed Partial Ureteral Obstruction After Bilateral Endoscopic Correction of Vesicoureteral Reflux With Dextranomer/Hyaluronic Acid Polymer
Endoscopic correction of vesicoureteral reflux using dextranomer/hyaluronic acid copolymer (Deflux) is a widely used technique. Complications are uncommon, and ureteral obstruction occurs particularly infrequently. We present a case of delayed symptomatic partial bilateral ureteral obstruction after bilateral..Nature and Fate of Supranormal Differential Renal Function: Lessons From Long-term Follow-up After Pyeloplasty
Urology
Nov 2012
Nature and Fate of Supranormal Differential Renal Function: Lessons From Long-term Follow-up After Pyeloplasty
Objective: To understand the nature and long-term fate of supranormal differential renal function (snDRF), analysis of a post-pyeloplasty database was performed. Materials and Methods: Preoperative diethylenetriaminepentaacetic acid (DTPA) diuretic renal scans (DRS) identified 33 children with snDRF (>55%)...Randomized Clinical Trial Comparing Effectiveness of Intracorpus Spongiosum Block Versus Topical Anesthesia for Performing Visual Internal Urethrotomy for Urethral Stricture Disease
Urology
Nov 2012
Randomized Clinical Trial Comparing Effectiveness of Intracorpus Spongiosum Block Versus Topical Anesthesia for Performing Visual Internal Urethrotomy for Urethral Stricture Disease
Objective: To compare the efficacy and safety of intracorpus spongiosum block (ICSB) over topical anesthesia for performing visual internal urethrotomy (VIU) in a randomized clinical trial. Methods: VIU for urethral stricture can be performed under various types of anesthesia, including topical anesthesia. Although..Vaginal Symptoms and Sexual Function After Tension-free Vaginal Tape-obturator Placement: Minimum 12-Month Follow-up
Urology
Nov 2012
Vaginal Symptoms and Sexual Function After Tension-free Vaginal Tape-obturator Placement: Minimum 12-Month Follow-up
Objective: To examine the effect of the tension-free vaginal tape-obturator (TVT-O) on sexual function and vaginal symptoms. The effect of anti-incontinence surgery on vaginal symptoms and sexual function is controversial; these assessments are increasingly important given the Food and Drug Administration warning..Determinants of Urolithiasis in Patients With Intestinal Fat Malabsorption
Urology
Nov 2012
Determinants of Urolithiasis in Patients With Intestinal Fat Malabsorption
Objective: To investigate the determinants of urinary stone formation in patients with fat malabsorption, because, although the prevalence of urolithiasis is greater in patients with intestinal diseases, the pathogenetic mechanisms and risk factors associated with urolithiasis in this population remain partially..The Mononuclear Phagocyte System in Kidney Disease and Repair
Nephrology
Nov 2012
The Mononuclear Phagocyte System in Kidney Disease and Repair
The mononuclear phagocyte system is comprised of circulating monocytes, tissue macrophages and dendritic cells (DCs) that play key roles in tissue homeostasis, immune surveillance, and immune and non-immune-mediated tissue injury and repair. This review summarises the various subsets within this system that exhibit..Insulin Resistance and Protein Metabolism in Chronic Hemodialysis Patients
Journal of Renal Nutrition
Nov 2012
Insulin Resistance and Protein Metabolism in Chronic Hemodialysis Patients
Objective: Loss of lean body mass (sarcopenia) is associated with increased morbidity and mortality in patients receiving chronic hemodialysis (CHD). Insulin resistance (IR), which is highly prevalent in patients receiving CHD, has been proposed to play a critical role in the development of sarcopenia. The aim of this..Can Renal Nutrition Education Improve Adherence to a Low-Protein Diet in Patients With Stages 3 to 5 Chronic Kidney Disease?
Journal of Renal Nutrition
Nov 2012
Can Renal Nutrition Education Improve Adherence to a Low-Protein Diet in Patients With Stages 3 to 5 Chronic Kidney Disease?
Objective: Low adherence is frequently observed in patients with chronic kidney disease (CKD) who are following a low-protein diet. We have evaluated whether a specific nutrition education program motivates patients with CKD who do not yet receive dialysis to reduce their protein intake and whether such a program..Urge perception index: a quantitative measure of bladder hyper-sensitivity in analysis of a bladder diary with a self-reported grading of urinary perception
Journal of Urology
Nov 2012
Urge perception index: a quantitative measure of bladder hyper-sensitivity in analysis of a bladder diary with a self-reported grading of urinary perception
Purpose: In analysis of a bladder diary with the patient’s self-reported urinary perception grades, we developed a quantitative measure of bladder hypersensitivity, which we refer to as the urge perception index (UPI). The aim of this study was to evaluate the impact of the UPI on defining the severity of overactive..Prognostic interest to discriminate muscularis mucosae invasion (T1a vs. T1b) in non-muscle-invasive bladder carcinomas: results from a French national multicentre study with a central pathology review
Journal of Urology
Nov 2012
Prognostic interest to discriminate muscularis mucosae invasion (T1a vs. T1b) in non-muscle-invasive bladder carcinomas: results from a French national multicentre study with a central pathology review
Purpose: Predictive factors of T1 non-muscle-invasive bladder cancer (NMIBC) evolution that could guide treatment decision making are lacking. Our aim was to assess the prognostic value of Muscularis mucosae (MM) invasion in NMIBC. Materials and methods: A national multicentric study recruited patients with primary T1..Surgically-induced chronic kidney disease may be associated with lesser risk of progression and mortality than medical chronic kidney disease
Journal of Urology
Nov 2012
Surgically-induced chronic kidney disease may be associated with lesser risk of progression and mortality than medical chronic kidney disease
Purpose: CKD from medical causes (CKD-M) is present in 25-30% prior to surgery for renal cancer. Although CKD-M is typically associated with 2-5% annual renal functional decline (RFD) and reduced overall survival, reduced GFR occurring only after surgery (CKD-S) may not have the same negative consequences. Methods: All..Pediatric Primary Urolithiasis: 12 Year Experience in a Mid-Western Children’s Hospital
Journal of Urology
Nov 2012
Pediatric Primary Urolithiasis: 12 Year Experience in a Mid-Western Children’s Hospital
Purpose: Due to environmental and social changes, including obesity, as new risk factors for stone formation in adults, and changes in imaging techniques utilized, the aims of this study were to assess if changes in etiologies of primary pediatric urolithiasis have occurred and if relationships exist between it and..Assisted reproductive techniques and the risk of the exstrophy-epispadias complex: a German case-control study
Journal of Urology
Nov 2012
Assisted reproductive techniques and the risk of the exstrophy-epispadias complex: a German case-control study
Purpose: To assess the risk for the exstrophy-epispadias-complex (EEC) following treatment for infertility with in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), two assisted reproductive techniques (ART). Materials and methods: Data of the German Network for Congenital Uro-REctal malformations..Extracorporeal shock wave lithotripsy is effective in treating single melamine-induced urolithiasis in infants and young children
Journal of Urology
Nov 2012
Extracorporeal shock wave lithotripsy is effective in treating single melamine-induced urolithiasis in infants and young children
Purpose: To evaluate the efficacy of extracorporeal shock wave lithotripsy (ESWL) in treating infant melamine-induced single urolithiasis. Materials and Methods: Between March 2009 and July 2010, 189 infants and young children with single melamine-induced urolithiasis were referred to our center for treatment by ESWL...Is the appearance of the Deflux Mound predictive of Reflux Resolution?
Journal of Urology
Nov 2012
Is the appearance of the Deflux Mound predictive of Reflux Resolution?
Purpose: To correlate the appearance of the Deflux mound after endoscopic correction of vesicoureteral reflux with the outcome. Material and Methods: We created an online survey based on 11 primary vesicoureteral reflux(VUR) cases (15 renal units, 6 failed and 9 successful procedures). Cases were selected randomly from..In Vitro Study of the Revised Ultrasound Based Real-Time Tracking of Renal Stones for Shock Wave Lithotripsy: Part 1
Journal of Urology
Nov 2012
In Vitro Study of the Revised Ultrasound Based Real-Time Tracking of Renal Stones for Shock Wave Lithotripsy: Part 1
Purpose: Extracorporeal Shock Wave Lithotripsy has been popular since 1980s. Of all the conventional lithotriptors, only 30% to 50% of shock waves are focused on stones. We developed an ultrasound based real-time stone tracking system (1st version) to improve accuracy and treatment efficiency. Yet, some problems..Androgen receptor expression relationship with semen variables in infertile men with varicocele
Journal of Urology
Nov 2012
Androgen receptor expression relationship with semen variables in infertile men with varicocele
Background: Androgen receptor (AR), a member of the nuclear receptor superfamily, plays important roles in male reproductive functions being required for sexual differentiation, pubertal development, regulation of spermatogenesis, completion of meiosis and transition of spermatocytes to haploid round spermatids...Natural History of Asymptomatic Renal Stones and Prediction of Stone-related Events
Journal of Urology
Nov 2012
Natural History of Asymptomatic Renal Stones and Prediction of Stone-related Events
Purpose: The appropriate management for asymptomatic renal stones remains unclear. The natural history and progression rate of such stones were assessed. Clinical factors associated with an increased risk of stone-related events were identified. Materials and Methods: Medical records of 347 (201 male and 146 female)..Circumcision and Lifetime Risk of Urinary Tract Infection: A Systematic Review and Meta-analysis
Journal of Urology
Nov 2012
Circumcision and Lifetime Risk of Urinary Tract Infection: A Systematic Review and Meta-analysis
Purpose: Urinary tract infection (UTI) is common in infant males who are uncircumcised and can lead to renal parenchymal disease of the still-growing pediatric kidney. Although the rate of UTI is highest in the first year of life, the cumulative incidence over the rest of the lifetime is under-recognized, but is..Combinations of urinary biomarkers for surveillance of patients with incident non-muscle invasive bladder cancer: The European FP7 UROMOL Project
Journal of Urology
Nov 2012
Combinations of urinary biomarkers for surveillance of patients with incident non-muscle invasive bladder cancer: The European FP7 UROMOL Project
Purpose: To determine a combination of markers with optimal sensitivity for detection of recurrences in voided urine after resection of an incident low-grade non-muscle invasive bladder tumor (NMIBC). Materials and methods: Patients with NMIBC G1/G2 (n=136) were included at trans-urethral resection of the incident..Characteristics and Clinical Outcomes of Hyponatremia in Peritoneal Dialysis Patients
Nephrology
Nov 2012
Characteristics and Clinical Outcomes of Hyponatremia in Peritoneal Dialysis Patients
Aim: There are few reports on the incidence, etiology, and mortality of peritoneal dialysis (PD) patients with hyponatremia. Methods: We identified all adults (>18-years-of-age) who received PD between May 2001 and March 2010. The patients were divided into two groups according to the presence of hyponatremia (<135..Body mass index influences prostate cancer risk at biopsy in Japanese men
International Journal of Urology
Nov 2012
Body mass index influences prostate cancer risk at biopsy in Japanese men
Objectives: To determine the relationship between body mass index and prostate cancer risk at biopsy in Japanese men, and to compared the risk with that of Caucasian men. Methods: We retrospectively evaluated 3966 men with prostate-specific antigen levels from 2.5 to 19.9 ng/mL who underwent an initial extended..Intrarenal reflux in primary vesicoureteral reflux
International Journal of Urology
Nov 2012
Intrarenal reflux in primary vesicoureteral reflux
Objectives: To elucidate the significance of intrarenal reflux. Methods: We retrospectively analyzed 276 patients (age <5 years) with grade III to V vesicoureteral reflux. They were divided into two groups: 55 patients with intrarenal reflux and 221 patients without intrarenal reflux (control group). All patients..Image-guided biopsy of small renal masses in the era of ablative therapies
International Journal of Urology
Nov 2012
Image-guided biopsy of small renal masses in the era of ablative therapies
Objective: To further evaluate the accuracy, safety, and impact of image-guided renal biopsies on clinical decision making and management of the indeterminate small renal masses. Methods: A total of 145 patients (males 99, females 46) with small renal masses suspicious for malignancy were evaluated during the study..Preoperative masked renal damage in Japanese patients with primary aldosteronism: Identification of predictors for chronic kidney disease manifested after adrenalectomy
International Journal of Urology
Nov 2012
Preoperative masked renal damage in Japanese patients with primary aldosteronism: Identification of predictors for chronic kidney disease manifested after adrenalectomy
Objective: Correct interpretation of renal function in patients with primary aldosteronism is difficult before adrenalectomy, because subtle kidney impairment is often masked by glomerular hyperfiltration peculiar to primary aldosteronism. The aim of this study was to investigate postoperative changes in renal function..Risk factors for chronic kidney disease after chemotherapy for testicular cancer
International Journal of Urology
Nov 2012
Risk factors for chronic kidney disease after chemotherapy for testicular cancer
Objective: To elucidate the patterns of and risk factors for deterioration of renal function after chemotherapy in metastatic testicular cancer survivors using the estimated glomerular filtration rate. Methods: A total of 96 patients who were treated with cisplatin-based chemotherapy for metastatic testicular cancer..Optimal strategy for penile rehabilitation after robot-assisted radical prostatectomy based on preoperative erectile function
BJU International
Nov 2012
Optimal strategy for penile rehabilitation after robot-assisted radical prostatectomy based on preoperative erectile function
What's known on the subject? and What does the study add? Removing of prostate for the treatment of localized prostate cancer is associated with a variable loss of erectile function due to injury of the nerves of erection during operation. Some researchers have reported that after nerve-sparing radical prostatectomy..Early results of a European multicentre experience with a new self-anchoring adjustable transobturator system for treatment of stress urinary incontinence in men
BJU International
Nov 2012
Early results of a European multicentre experience with a new self-anchoring adjustable transobturator system for treatment of stress urinary incontinence in men
What's known on the subject? and What does the study add? Surgical treatment options for male stress urinary incontinence (SUI) include collagen injection, artificial urinary sphincter, or male sling placement. In recent years, various minimally invasive sling systems have been investigated as treatment options for..Local recurrence after retropubic radical prostatectomy for prostate cancer does not exclusively occur at the anastomotic site
BJU International
Nov 2012
Local recurrence after retropubic radical prostatectomy for prostate cancer does not exclusively occur at the anastomotic site
What's known on the subject? and What does the study add? Local recurrence after radical prostatectomy (RP) for clinically organ-confined prostate cancer is largely assumed to occur at the anastomotic site, as reflected in European and North American guidelines for adjuvant and salvage radiotherapy after RP. However,..Induction and Maintenance Treatment of Proliferative Lupus Nephritis: A Meta-Analysis of Randomized Controlled Trials
American Journal of Kidney Diseases
Nov 2012
Induction and Maintenance Treatment of Proliferative Lupus Nephritis: A Meta-Analysis of Randomized Controlled Trials
Background: Lupus nephritis accounts for ∼1% of patients starting dialysis therapy. Treatment regimens combining cyclophosphamide with steroids preserve kidney function but have significant side effects. Newer immunosuppressive agents may have improved toxicity profiles. Study Design: Systematic review and..The Perspectives of Adults Living With Peritoneal Dialysis: Thematic Synthesis of Qualitative Studies
American Journal of Kidney Diseases
Nov 2012
The Perspectives of Adults Living With Peritoneal Dialysis: Thematic Synthesis of Qualitative Studies
Background: Most patients with end-stage renal disease require dialysis to survive because they are unable to access kidney transplantation. Peritoneal dialysis (PD) is recommended by some clinical practice guidelines as the dialysis treatment of choice for adults without significant comorbid conditions or those with..Estimating the Total Incidence of Kidney Failure in Australia Including Individuals Who Are Not Treated by Dialysis or Transplantation
American Journal of Kidney Diseases
Nov 2012
Estimating the Total Incidence of Kidney Failure in Australia Including Individuals Who Are Not Treated by Dialysis or Transplantation
Background: To date, incidence data for kidney failure in Australia have been available for only those who start renal replacement therapy (RRT). Information about the total incidence of kidney failure, including non–RRT-treated cases, is important to help understand the burden of kidney failure in the community and..Anuric Acute Kidney Injury in Neurofibromatosis 1
American Journal of Kidney Diseases
Nov 2012
Anuric Acute Kidney Injury in Neurofibromatosis 1
Neurofibromatosis is one of several genetic disorders characterized by hyperpigmented skin spots (café au lait spots) and multiple neurofibromas. It was first reported by Friedrich Daniel von Recklinghausen in 1882. There are 2 types of neurofibromatosis described in the literature: von Recklinghausen disease, or..Hemodialysis Access Usage Patterns in the Incident Dialysis Year and Associated Catheter-Related Complications
American Journal of Kidney Diseases
Nov 2012
Hemodialysis Access Usage Patterns in the Incident Dialysis Year and Associated Catheter-Related Complications
Background: Hemodialysis (HD) access is considered a critical and actionable determinant of morbidity, with a growing literature suggesting that initial HD access type is an important marker of long-term outcomes. Accordingly, we examined HD access during the incident dialysis period, focusing on infection risk and..Pulmonary Hypertension in CKD
American Journal of Kidney Diseases
Nov 2012
Pulmonary Hypertension in CKD
Pulmonary arterial hypertension is a rare disease often associated with positive antinuclear antibody and high mortality. Pulmonary hypertension, which rarely is severe, occurs frequently in patients with chronic kidney disease (CKD). The prevalence of pulmonary hypertension ranges from 9%-39% in individuals with stage..Hemoglobin Stability in Patients With Anemia, CKD, and Type 2 Diabetes: An Analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) Placebo Arm
American Journal of Kidney Diseases
Nov 2012
Hemoglobin Stability in Patients With Anemia, CKD, and Type 2 Diabetes: An Analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) Placebo Arm
Background: Sparse data are available about the natural history of hemoglobin (Hb) level trends in contemporary patients with anemia, chronic kidney disease (CKD), and type 2 diabetes mellitus. We intended to describe Hb level trends over time with no or minimal administration of erythropoiesis-stimulating agents...Impact of gene polymorphisms of interleukin-18, transforming growth factor-β, and vascular endothelial growth factor on development of IgA nephropathy and thin glomerular basement membrane disease
Kidney Research and Clinical Practice
Nov 2012
Impact of gene polymorphisms of interleukin-18, transforming growth factor-β, and vascular endothelial growth factor on development of IgA nephropathy and thin glomerular basement membrane disease
Background: We investigated the effects of gene polymorphisms on the development of IgA nephropathy and thin glomerular basement membrane (GBM) disease by analyzing polymorphisms in the interleukin (IL)-18, transforming growth factor (TGF)-β, and vascular endothelial growth factor (VEGF) genes in Korean patients...A case of membranous nephropathy associated with relapsing polychondritis
Kidney Research and Clinical Practice
Nov 2012
A case of membranous nephropathy associated with relapsing polychondritis
Relapsing polychondritis (RP) is a rare, chronic, and potentially fatal multisystemic inflammatory disorder targeting cartilaginous structures. This disorder is frequently associated with rheumatoid arthritis, systemic vasculitis, connective tissue diseases, and hematologic disorders, but renal involvement is unusual...Effects of Sodium Intake and Diet on Racial Differences in Urinary Potassium Excretion: Results From the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial
American Journal of Kidney Diseases
Nov 2012
Effects of Sodium Intake and Diet on Racial Differences in Urinary Potassium Excretion: Results From the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial
Background: We previously showed that African Americans excreted less urinary potassium than whites, even while consuming similar diets in the Dietary Approaches to Stop Hypertension (DASH) trial. We hypothesized that a low-sodium diet may eliminate these differences. Study Design: Data from the DASH-Sodium randomized..Effects of Sodium Intake and Diet on Racial Differences in Urinary Potassium Excretion: Results From the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial
American Journal of Kidney Diseases
Nov 2012
Effects of Sodium Intake and Diet on Racial Differences in Urinary Potassium Excretion: Results From the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial
Background: We previously showed that African Americans excreted less urinary potassium than whites, even while consuming similar diets in the Dietary Approaches to Stop Hypertension (DASH) trial. We hypothesized that a low-sodium diet may eliminate these differences. Study Design: Data from the DASH-Sodium randomized..Effect of Early Initiation of Dialysis on Cardiac Structure and Function: Results From the Echo Substudy of the IDEAL Trial
American Journal of Kidney Diseases
Nov 2012
Effect of Early Initiation of Dialysis on Cardiac Structure and Function: Results From the Echo Substudy of the IDEAL Trial
Background: Abnormalities of cardiac structure and function are common in patients undergoing dialysis, and cardiovascular disease is the major cause of mortality in this group. Heart failure is a common clinical manifestation of cardiovascular disease and is preceded by left ventricular hypertrophy (LVH). There are..Abdominal Compartment Syndrome and Acute Kidney Injury Due to Excessive Auto–Positive End-Expiratory Pressure
American Journal of Kidney Diseases
Nov 2012
Abdominal Compartment Syndrome and Acute Kidney Injury Due to Excessive Auto–Positive End-Expiratory Pressure
Abdominal compartment syndrome is an under-recognized cause of acute kidney injury in critically ill patients. We report a case of a patient with severe obstructive lung disease who, while intubated for respiratory failure, developed abdominal compartment syndrome and oliguric acute kidney injury due to air-trapping..Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly
Archives of Gerontology and Geriatrics
Nov 2012
Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly
Prognostic values of N-terminal pro-brain natriuretic peptide (NT-proBNP) in myriad diseases have been studied. During the natural progression of atherosclerotic renal artery disease (ARVD) changes of NT-proBNP levels and its significance is not understood. A prospective longitudinal follow-up study was conducted among..Protective Effects of Reducing Renal Ischemia-reperfusion Injury During Renal Hilar Clamping: Use of Allopurinol as a Nephroprotective Agent
Urology
Nov 2012
Protective Effects of Reducing Renal Ischemia-reperfusion Injury During Renal Hilar Clamping: Use of Allopurinol as a Nephroprotective Agent
Objective: To investigate the relationship between renal ischemia injury and concentrations of 8-isoprostane in a rat kidney model during renal hilar clamping and their correlation with the administration of allopurinol before clamping. Materials and Methods: Reperfusion injury occurs after the reintroduction of blood..Simvastatin Suppresses Cyclophosphamide-induced Changes in Urodynamics and Bladder Inflammation
Urology
Nov 2012
Simvastatin Suppresses Cyclophosphamide-induced Changes in Urodynamics and Bladder Inflammation
Objective: To assess the ability of daily oral simvastatin administration to reduce the negative urodynamic changes associated with cyclophosphamide (CP)-induced cystitis and to prevent bladder inflammation. Patients undergoing CP chemotherapy frequently develop cystitis, leading to urinary dysfunction and hemorrhage...Inducing Cell Proliferation Inhibition, Apoptosis, and Motility Reduction by Silencing Long Noncoding Ribonucleic Acid Metastasis-associated Lung Adenocarcinoma Transcript 1 in Urothelial Carcinoma of the Bladder
Urology
Nov 2012
Inducing Cell Proliferation Inhibition, Apoptosis, and Motility Reduction by Silencing Long Noncoding Ribonucleic Acid Metastasis-associated Lung Adenocarcinoma Transcript 1 in Urothelial Carcinoma of the Bladder
Objective: To study the expression patterns of long noncoding ribonucleic acid (RNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the cell proliferation inhibition, apoptosis, and motility changes induced by silencing MALAT1 in urothelial carcinoma of the bladder. Materials and Methods: The..Effect of Diabetes on the Ion Pumps of the Bladder
Urology
Nov 2012
Effect of Diabetes on the Ion Pumps of the Bladder
Objective: To establish whether the activities of Na+/K+-adenosine triphosphatase (ATPase) and Ca2+-ATPases ion pumps in bladder smooth muscle are altered as a consequence of diabetes and, if so, how this might contribute to bladder cystopathy. Urinary bladder dysfunction is a common occurrence in patients with..Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Urology
Nov 2012
Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Objective: To evaluate the outcomes of robotic partial nephrectomy (RPN) for solitary kidney in a large multicenter series. Materials and Methods: Medical records of 886 consecutive patients who underwent RPN at 5 academic institutions from May 2007 to May 2012 were retrospectively analyzed. Data were prospectively..Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Urology
Nov 2012
Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Objective: To evaluate the outcomes of robotic partial nephrectomy (RPN) for solitary kidney in a large multicenter series. Materials and Methods: Medical records of 886 consecutive patients who underwent RPN at 5 academic institutions from May 2007 to May 2012 were retrospectively analyzed. Data were prospectively..Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Urology
Nov 2012
Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Objective: To evaluate the outcomes of robotic partial nephrectomy (RPN) for solitary kidney in a large multicenter series. Materials and Methods: Medical records of 886 consecutive patients who underwent RPN at 5 academic institutions from May 2007 to May 2012 were retrospectively analyzed. Data were prospectively..Incidence, Risk Factors, and Complications of Postoperative Delirium in Elderly Patients Undergoing Radical Cystectomy
Urology
Nov 2012
Incidence, Risk Factors, and Complications of Postoperative Delirium in Elderly Patients Undergoing Radical Cystectomy
Objective: To identify the risk factors for, and complications associated with, the development of delirium after radical cystectomy. Materials and Methods: From July 2008 to December 2009, 59 patients, aged ≥65 years and undergoing radical cystectomy, were prospectively enrolled. The baseline cognitive status was..Knowledge and Attitude of European Urology Residents About Ionizing RadiationKnowledge and Attitude of European Urology Residents About Ionizing Radiation
Urology
Nov 2012
Knowledge and Attitude of European Urology Residents About Ionizing RadiationKnowledge and Attitude of European Urology Residents About Ionizing Radiation
Objective To evaluate the attitude and knowledge of urology residents concerning ionizing radiation, we undertook a survey of European urology residents. Methods The questionnaire was sent to 1184 urology residents within the database of the European Society of Residents in Urology (ESRU) by e-mail between November..Hypertension in Pediatric Patients With Renal Scarring in Association With Vesicoureteral Reflux
Urology
Nov 2012
Hypertension in Pediatric Patients With Renal Scarring in Association With Vesicoureteral Reflux
Objective: To examine the reflux nephropathy rate and severity as well as the hypertension rate in pediatric patients with vesicoureteral reflux (VUR). Methods: The study included 240 patients with VUR. Renal scarring (RS) was demonstrated by renal parenchymal examination using technetium-99m–labeled dimercaptosuccinic..Occurrence of Dysplasia and Human Papilloma Virus Typing in Penile Condylomas
Urology
Nov 2012
Occurrence of Dysplasia and Human Papilloma Virus Typing in Penile Condylomas
Objective: To determine the incidence of dysplasia as a preneoplastic change and high-risk human papilloma virus (HPV) infection in penile condylomas, which are common HPV-related lesions and considered a risk factor for penile cancer. Methods: Histologic analysis was done of 58 consecutive penile condylomas with..Probability of Downsizing Primary Tumors of Renal Cell Carcinoma by Targeted Therapies Is Related to Size at Presentation
Urology
Nov 2012
Probability of Downsizing Primary Tumors of Renal Cell Carcinoma by Targeted Therapies Is Related to Size at Presentation
Objective: To evaluate the probability of downsizing primary renal tumors by targeted therapy in correlation to size. Methods: A literature search was conducted and our own data were pooled with data of retrospective series and prospective trials in which patients were treated with tyrosine kinase inhibitors (TKIs) and..Contemporary Urethral Stricture Characteristics in the Developed World
Urology
Nov 2012
Contemporary Urethral Stricture Characteristics in the Developed World
Objective: To assess the current etiology, features, and natural history of urethral stricture disease in the developed world. Materials and Methods: We analyzed the data from 1439 male patients with urethral stricture, who had undergone surgical treatment in our referral urethral center from 2000 to 2010. The..Better Irrigation Delivers Better Vision: An Exploratory Study of a Novel Continuous Irrigation Sheath for a Flexible Cystoscope
Urology
Nov 2012
Better Irrigation Delivers Better Vision: An Exploratory Study of a Novel Continuous Irrigation Sheath for a Flexible Cystoscope
Objective: To evaluate the effectiveness of a novel continuous irrigation sheath (NCIS) for improving the vision of a flexible cystoscope under gross hematuria and to investigate whether this NCIS increases patient discomfort. Methods: A model was designed and a trial was conducted to quantitatively evaluate the..Laparoendoscopic Single Site (LESS) In Vivo Suturing Using a Magnetic Anchoring and Guidance System (MAGS) Camera in a Porcine Model: Impact on Ergonomics and Workload
Urology
Nov 2012
Laparoendoscopic Single Site (LESS) In Vivo Suturing Using a Magnetic Anchoring and Guidance System (MAGS) Camera in a Porcine Model: Impact on Ergonomics and Workload
Objective: To compare the ergonomics and workload of the surgeon during single-site suturing while using the magnetic anchoring and guidance system (MAGS) camera vs a conventional laparoscope. Methods: Seven urologic surgeons were enrolled and divided into an expert group (n = 2) and a novice group (n = 5) according to..A case of membranous nephropathy as a manifestation of graft-versus-host disease
Kidney Research and Clinical Practice
Nov 2012
A case of membranous nephropathy as a manifestation of graft-versus-host disease
Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human..Permeability factors in nephrotic syndrome and focal segmental glomerulosclerosis
Kidney Research and Clinical Practice
Nov 2012
Permeability factors in nephrotic syndrome and focal segmental glomerulosclerosis
Circulating permeability factors have been identified in the plasma of patients with focal segmental glomerulosclerosis (FSGS). Post-transplant recurrence of proteinuria, improvement of proteinuria after treatment with plasmapheresis, and induction of proteinuria in experimental animals by plasma fractions each provide..Serum IgA/C3 Ratio Predicts progression of IgA Nephropathy
Nephrology
Nov 2012
Serum IgA/C3 Ratio Predicts progression of IgA Nephropathy
Background The serum IgA/C3 ratio has been shown to be a good predictor of histological lesions and prognosis for patients with IgA nephropathy (IgAN) in Japanese. But its validity in Chinese population is unclear. We sought to explore the long-term outcomes of IgAN, its clinical and histopathological predictors in..Hemoglobin variability in the early post-transplant period: Association with graft survival and mortality
Nephrology
Nov 2012
Hemoglobin variability in the early post-transplant period: Association with graft survival and mortality
Aim: Hemoglobin (Hb) variability is associated with poor survival in patients with chronic kidney disease. Association of Hb variability after kidney transplantation with patients′ and graft survival has not been adequetly studied. Methods: This retrospective study used registry data to examine the association between..Treatment with curative intent and survival in men with high-risk prostate cancer. A population-based study of 11 380 men with serum PSA level 20–100 ng/mL
BJU International
Jul 2012
Treatment with curative intent and survival in men with high-risk prostate cancer. A population-based study of 11 380 men with serum PSA level 20–100 ng/mL
What's known on the subject? and What does the study add? There are two randomized controlled trials showing that radiotherapy can be beneficial for men with locally advanced prostate cancer. The present study confirms the importance of curative treatment for men with high-risk prostate cancer. Objective: To..Managing Older Adults With CKD: Individualized Versus Disease-Based Approaches
American Journal of Kidney Diseases
Dec 2011
Managing Older Adults With CKD: Individualized Versus Disease-Based Approaches
The last decade has seen the evolution and ongoing refinement of a disease-oriented approach to chronic kidney disease (CKD). Disease-oriented models of care assume a direct causal association between observed signs and symptoms and underlying disease pathophysiologic processes. Treatment plans target underlying..ANCA-Associated Glomerulonephritis in Systemic-Onset Juvenile Idiopathic Arthritis
American Journal of Kidney Diseases
Dec 2011
ANCA-Associated Glomerulonephritis in Systemic-Onset Juvenile Idiopathic Arthritis
Systemic-onset juvenile idiopathic arthritis is an inflammatory disease of unknown cause and is not commonly associated with kidney involvement. We describe 3 patients with systemic-onset juvenile idiopathic arthritis with high disease activity who developed antineutrophil cytoplasmic antibody (ANCA)-associated..Body mass index has no effect on rate of progression of chronic kidney disease in subjects with type 2 diabetes mellitus
Journal of Nephrology
Dec 2011
Body mass index has no effect on rate of progression of chronic kidney disease in subjects with type 2 diabetes mellitus
Background: The incidences of obesity and chronic kidney disease (CKD) are reaching epidemic levels. Recently obesity has been associated with the development of CKD. However, it is unclear whether obesity is a risk factor for the progression of CKD. This study investigated the effect of raised body mass index (BMI,..The modern staged repair of classic bladder exstrophy: A detailed postoperative management strategy for primary bladder closure
Journal of Pediatric Urology
Nov 2011
The modern staged repair of classic bladder exstrophy: A detailed postoperative management strategy for primary bladder closure
Purpose: Successful primary bladder closure of classic bladder exstrophy sets the stage for development of adequate bladder capacity and eventual voided continence. The postoperative pathway following primary bladder closure at the authors’ institution is quantitatively and qualitatively detailed. Materials and..G-Protein Coupled Receptor Kinase 5 Regulates Prostate Tumor Growth
The Journal of Urology
Nov 2011
G-Protein Coupled Receptor Kinase 5 Regulates Prostate Tumor Growth
Purpose: The limited success of cancer therapeutics is largely attributable to the ability of cancer to become resistant to conventional cytotoxic chemotherapy. Thus, further identification of signaling molecules and pathways that influence tumorigenesis is needed to increase the overall therapeutic options. GRKs,..Calcium Phosphate Content Does Not Affect Stone-Free Rate After Percutaneous Nephrolithotomy
The Journal of Urology
Nov 2011
Calcium Phosphate Content Does Not Affect Stone-Free Rate After Percutaneous Nephrolithotomy
Purpose: Recent research suggests that the stone-free rate for percutaneous nephrostolithotomy is lower in patients with calcium phosphate stones than in those with stones of other compositions. We reviewed our percutaneous nephrostolithotomy outcomes to investigate this unexplained finding. Materials and Methods: A..Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
Experimental Diabetes Research
Aug 2011
Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
Aims: Patients with diabetic nephropathy are reported to have a high prevalence of left ventricular structural and functional abnormalities. This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at various stages of..From chronic kidney disease to transplantation: The roles of obestatin
Regulatory Peptides
Jul 2011
From chronic kidney disease to transplantation: The roles of obestatin
Kidney transplantation is the therapy of choice in most cases of end stage renal disease. The purpose of the present study was to evaluate serum obestatin levels in kidney transplant recipients (Tx), compare levels in patients with renal failure (CKD) with those in healthy subjects (HS), and to assess the role of this..Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model
Clinical Science
Jun 2011
Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model
CKD (chronic kidney disease) has become a public health problem. The therapeutic approaches have been able to reduce proteinuria, but have not been successful in limiting disease progression. In this setting, cell therapies associated with regenerative effects are attracting increasing interest. We evaluated the effect..
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