Internal Medicine Medical Journal Abstracts
Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: A systematic review
Cancer Treatment Reviews
Feb 2013
Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: A systematic review
Background and aims; The use of oral anticancer drugs has increased in modern oncology treatment. The move from intravenous treatments towards oral anticancer drugs has increased the patients’ own responsibility to take oral anticancer drugs as being prescribed. High rates of non-adherence to oral anticancer drugs have..Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities
Cancer Treatment Reviews
Feb 2013
Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities
By the introduction of molecularly targeted anti-cancer drugs, that are designed to intervene with specific pathways aberrant in cancers with distinct mutations, the type of adverse events encountered has changed greatly compared to the adverse events profile of classical chemotherapeutic agents. Ocular toxicities,..Evaluation of 5-year imatinib treatment of 458 patients with CP-CML in routine clinical practice and prognostic impact of different BCR-ABL cutoff levels
Cancer Medicine
Feb 2013
Evaluation of 5-year imatinib treatment of 458 patients with CP-CML in routine clinical practice and prognostic impact of different BCR-ABL cutoff levels
We evaluated responses to the treatment and long-term outcomes of chronic myeloid leukemia patients treated with imatinib as first-line treatment in routine clinical setting from two countries with centralized tyrosine kinase inhibitors (TKIs) treatment. We assessed prognostic significance of European LeukemiaNet (ELN)..HER2-targeted therapy in breast cancer: A systematic review of neoadjuvant trials
Cancer Treatment Reviews
Feb 2013
HER2-targeted therapy in breast cancer: A systematic review of neoadjuvant trials
Targeting human epidermal growth factor receptor 2 (HER2) during or in sequence with chemotherapy improves overall survival in metastatic and early HER2-overexpressing breast cancer. In this paper we systematically review neoadjuvant clinical trial data in HER2-positive breast cancer and discuss key unanswered clinical..Revisiting ovarian cancer preclinical models: Implications for a better management of the disease
Cancer Treatment Reviews
Feb 2013
Revisiting ovarian cancer preclinical models: Implications for a better management of the disease
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite progress in identifying “hallmark” genetic alterations associated with the main subtypes of epithelial ovarian cancer, the survival rate of women with EOC changed little since platinum-based treatment was introduced more than 30years..Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial
The Lancet
Feb 2013
Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial
Background: Rituximab plus chemotherapy, most often CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), is the first-line standard of care for patients with advanced indolent lymphoma, and for elderly patients with mantle-cell lymphoma. Bendamustine plus rituximab is effective for relapsed or refractory..Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial
The Lancet
Feb 2013
Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial
Background: Colonoscopy is the gold-standard test for investigation of symptoms suggestive of colorectal cancer; computed tomographic colonography (CTC) is an alternative, less invasive test. However, additional investigation after CTC is needed to confirm suspected colonic lesions, and this is an important factor in..CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01)
The Lancet Oncology
Feb 2013
CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01)
Background: Several randomised trials have confirmed the benefit of adjuvant trastuzumab for patients with HER2-positive early breast cancer. However, concern has been expressed that adjuvant trastuzumab might be associated with an increased frequency of CNS relapses. We assessed the frequency and course of CNS..Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial
The Lancet Oncology
Feb 2013
Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial
Background: Insulin-like growth factors (IGF-1 and IGF-2) bind to the IGF-1 receptor (IGF-1R), increasing cell proliferation and survival. Ganitumab is a monoclonal IgG1 antibody that blocks IGF-1R. We tested the efficacy and safety of adding ganitumab to endocrine treatment for patients with hormone-receptor-positive..Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial
The Lancet Oncology
Feb 2013
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial
Background: The relative efficacy of the addition of induction chemotherapy to chemoradiotherapy compared with chemoradiotherapy alone for patients with head and neck cancer is unclear. The PARADIGM study is a multicentre open-label phase 3 study comparing the use of docetaxel, cisplatin, and fluorouracil (TPF)..MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
The Lancet Oncology
Feb 2013
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
Background: Patients with melanoma harbouring Val600 BRAF mutations benefit from treatment with BRAF inhibitors. However, no targeted treatments exist for patients with BRAF wild-type tumours, including those with NRAS mutations. We aimed to assess the use of MEK162, a small-molecule MEK1/2 inhibitor, in patients with..Drilling of bone: A comprehensive review
Journal of Orthopaedics, Trauma and Rehabilitation
Feb 2013
Drilling of bone: A comprehensive review
Background: Bone fracture treatment usually involves restoring of the fractured parts to their initial position and immobilizing them until the healing takes place. Drilling of bone is common to produce hole for screw insertion to fix the fractured parts for immobilization. Orthopaedic drilling during surgical process..Impaired glucose metabolism is a risk factor for increased thyroid volume and nodule prevalence in a mild-to-moderate iodine deficient area
Metabolism
Feb 2013
Impaired glucose metabolism is a risk factor for increased thyroid volume and nodule prevalence in a mild-to-moderate iodine deficient area
Objective: Insulin resistance (IR) is a key factor involved in the pathogenesis of impaired glucose metabolism. IR is associated with increased thyroid volume and nodule prevalence in patients with metabolic syndrome. Data on the association of thyroid morphology and abnormal glucose metabolism are limited. This..Newly diagnosed multiple sclerosis in state of Qatar
Clinical Neurology and Neurosurgery
Feb 2013
Newly diagnosed multiple sclerosis in state of Qatar
Background: Epidemiologic studies on multiple sclerosis (MS) are well-documented in the western population but to a lesser extent in Arab world. Objective: To study the demographics, clinical aspects, radiologic and laboratory features along with the degree of disability inflicted, and factors affecting disease..Maternal low-protein diet alters the expression of real-time quantitative polymerase chain reaction reference genes in an age-, sex-, and organ-dependent manner in rat offspring
Nutrition Research
Feb 2013
Maternal low-protein diet alters the expression of real-time quantitative polymerase chain reaction reference genes in an age-, sex-, and organ-dependent manner in rat offspring
Altered perinatal environment, often manifested as low birth weight, is thought to contribute to greater susceptibility for hypertension, hyperlipidemia, and diabetes as a result of epigenetic modifications and alteration of transcriptional activity for key genes. Real-time polymerase chain reaction is a useful..Metabolically obese status with normal weight is associated with both the prevalence and severity of angiographic coronary artery disease
Metabolism
Feb 2013
Metabolically obese status with normal weight is associated with both the prevalence and severity of angiographic coronary artery disease
Objective: We evaluated prevalence and severity of angiographic coronary artery disease (CAD) according to groups by metabolically obese (MO) and/or weight status. Material/methods: Normal weight was defined as body mass index (BMI, kg/m2)<25 and obesity was defined as BMI≥25. The MO was determined using the National..Chronic cerebrospinal venous insufficiency in multiple sclerosis: A sonographer-blinded case-control study
Clinical Neurology and Neurosurgery
Feb 2013
Chronic cerebrospinal venous insufficiency in multiple sclerosis: A sonographer-blinded case-control study
Objectives: To evaluate the presence of chronic cerebrospinal venous insufficiency (CCSVI) and cerebral venous anomalies in a consecutive series of patients with multiple sclerosis (MS), other neurologic diseases (NEU) and healthy controls (HC). Methods: A consecutive series of 80 MS patients, 41 HC and 40 NEU cases..Magnetoencephalography localizing spike sources of atypical benign partial epilepsy
Brain and Development
Feb 2013
Magnetoencephalography localizing spike sources of atypical benign partial epilepsy
Rationale: Atypical benign partial epilepsy (ABPE) is characterized by centro-temporal electroencephalography (EEG) spikes, continuous spike and waves during sleep (CSWS), and multiple seizure types including epileptic negative myoclonus (ENM), but not tonic seizures. This study evaluated the localization of..Quality of Life after Radical Radiotherapy for Prostate Cancer: Longitudinal Study from a Randomised Trial of External Beam Radiotherapy Alone or in Combination with High Dose Rate Brachytherapy
Clinical Oncology
Feb 2013
Quality of Life after Radical Radiotherapy for Prostate Cancer: Longitudinal Study from a Randomised Trial of External Beam Radiotherapy Alone or in Combination with High Dose Rate Brachytherapy
Aim: To compare prospective, long-term quality of life in patients randomised to external beam radiotherapy (EBRT) alone or with a boost of high dose rate (HDR) brachytherapy. Materials and methods: In total, 216 patients participating in the UK randomised trial of EBRT ± HDR brachytherapy were included in this..Subacute peripheral and optic neuropathy syndrome with no evidence of a toxic or nutritional cause
Clinical Neurology and Neurosurgery
Feb 2013
Subacute peripheral and optic neuropathy syndrome with no evidence of a toxic or nutritional cause
Background: The syndrome of subacute simultaneous peripheral neuropathy and bilateral optic neuropathy is known to occur in tropical countries, probably due to malnutrition or toxicity, but not often seen in developed countries. We report seven patients in London who were not malnourished or alcoholic, and in whom no..A national study of the provision of oncology sperm banking services among Canadian fertility clinics
European Journal of Cancer Care
Feb 2013
A national study of the provision of oncology sperm banking services among Canadian fertility clinics
The purpose of this study was to survey the current state of oncology sperm banking services provided by fertility clinics across Canada. A total of 78 Canadian fertility facilities were invited to complete a questionnaire related to the availability, accessibility, affordability and utilisation of sperm banking..A neurodevelopmental basis for BECTS: Evidence from structural MRI
Epilepsy Research
Feb 2013
A neurodevelopmental basis for BECTS: Evidence from structural MRI
Purpose: BECTS (benign epilepsy with centro-temporal spikes) is one of the most common childhood-onset epilepsy syndromes. We investigated quantitative evidence for brain morphological variation associated with BECTS to provide insights into the neuroanatomical basis of this disorder. Methods: Three independent BECTS..A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers
Nutrition Research
Feb 2013
A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers
It has been suggested that anthocyanin-rich foods may exert antioxidant effects and improve vascular function as demonstrated mainly in vitro and in the animal model. Blueberries are rich sources of anthocyanins and we hypothesized that their intake could improve cell protection against oxidative stress and affect..A Test of Agreement of Customised Birthweight Models
Paediatric and Perinatal Epidemiology
Feb 2013
A Test of Agreement of Customised Birthweight Models
Background: The objective of this study was to determine whether the physiological effects on birthweight as described by customised birthweight models (CBMs) from various populations and locations are consistent when applied to a single sample. Methods: The predicted birthweight was calculated for 52 826..A thoracic surgeon's perspective on the elastofibroma dorsi: A benign tumor of the deep infrascapular region
Thoracic Cancer
Feb 2013
A thoracic surgeon's perspective on the elastofibroma dorsi: A benign tumor of the deep infrascapular region
Background: An elastofibroma is a benign, soft-tissue tumor and is important in the differential diagnosis of thoracic wall masses. Here, patients with elastofibromas who underwent thoracic surgery were retrospectively reviewed to elucidate elastofibroma formation and to facilitate the differential diagnosis. Methods:..Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients
Thoracic Cancer
Feb 2013
Angiopoietin 2 levels in serum and bronchial lavage fluids and their relationship with cancer stages in lung cancer patients
Background: An elastofibroma is a benign, soft-tissue tumor and is important in the differential diagnosis of thoracic wall masses. Here, patients with elastofibromas who underwent thoracic surgery were retrospectively reviewed to elucidate elastofibroma formation and to facilitate the differential diagnosis. Methods:..Anthracycline induced cardiac toxicity in pediatric Ewing sarcoma: A longitudinal study
Pediatric Blood & Cancer
Feb 2013
Anthracycline induced cardiac toxicity in pediatric Ewing sarcoma: A longitudinal study
Background: Reports on incidence and factors associated with anthracycline cardiotoxicity in patients with Ewing sarcoma vary and few studies evaluate effect over time. Longitudinal trends in cardiac function and prognostic value of % decline in ejection fraction (EF) during therapy have not been previously described..Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects
Metabolism
Feb 2013
Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects
Objective: The clinical significance of the measurement of serum PCSK9 (proprotein subtilisin kexin type 9) is not well defined. This study investigated the association between serum PCSK9 levels and atherosclerosis assessed by carotid intima media thickness (IMT) in hypertensive patients. Methods: A total of 126..Birth order and transplant outcome in HLA-identical sibling stem cell transplantation – an analysis on behalf of the Center for International Blood and Marrow Transplantation (CIBMTR)
Biology of Blood and Marrow Transplantation
Feb 2013
Birth order and transplant outcome in HLA-identical sibling stem cell transplantation – an analysis on behalf of the Center for International Blood and Marrow Transplantation (CIBMTR)
Background: Allogeneic stem cell transplantation is the most effective treatment option for many hematological malignancies, but graft-versus-host-disease (GvHD) remains a major cause of treatment failure. Besides well established risk factors for the outcome of transplantation, recent single-center studies have..Blood Component Recalls and Market Withdrawals: Frequency, Reasons, and Management in the United States
Transfusion Medicine Reviews
Feb 2013
Blood Component Recalls and Market Withdrawals: Frequency, Reasons, and Management in the United States
In a previous article, we reviewed the management of blood component recalls and withdrawals (G. Ramsey. Transfusion Med Rev 2004;18:36–45). Since then, US rates of recall and biological product deviation for blood components have improved significantly, particularly with regard to reduced recalls for donor infectious..Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness
Metabolism
Feb 2013
Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness
Objective: To identify novel biomarkers through metabolomic profiles that distinguish metabolically well (MW) from metabolically unwell (MUW) individuals, independent of body mass index (BMI). Materials/Methods: This study was conducted as part of the Measurement to Understand the Reclassification of Disease of..Calculating the tumor volume of acoustic neuromas: Comparison of ABC/2 formula with planimetry method
Clinical Neurology and Neurosurgery
Feb 2013
Calculating the tumor volume of acoustic neuromas: Comparison of ABC/2 formula with planimetry method
Objective: The ABC/2 equation is commonly applied to measure the volume of intracranial hematoma. However, the precision of ABC/2 equation in estimating the tumor volume of acoustic neuromas is less addressed. The study is to evaluate the accuracy of the ABC/2 formula by comparing with planimetry method for estimating..Clinical profile, treatment response, and outcome of HIV-TB co-infected children
Pediatric Infectious Disease
Feb 2013
Clinical profile, treatment response, and outcome of HIV-TB co-infected children
Background: We studied the clinical presentation, treatment response and outcome in children with HIV-TB co-infection, registered at PCOE, Indira Gandhi Institute of Child Health, Bangalore. Methods: All 590 HIV infected children registered at our center were evaluated for TB infection. Information on TB was collected..CMV-specific cytotoxic T lymphocytes can be efficiently expanded from G-CSF mobilised haemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplant recipients
Biology of Blood and Marrow Transplantation
Feb 2013
CMV-specific cytotoxic T lymphocytes can be efficiently expanded from G-CSF mobilised haemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplant recipients
Uncontrolled cytomegalovirus (CMV) reactivation following allogeneic haemopoietic stem cell transplantation causes significant morbidity and mortality. Adoptive transfer of CMV-specific cytotoxic T lymphocytes (CTL) is a promising therapy to treat reactivation and prevent viral disease. In this study we describe the..Defining Incidence, Risk Factors, and Impact on Survival of Central Line-Associated Blood Stream Infections Following Hematopoietic Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome
Biology of Blood and Marrow Transplantation
Feb 2013
Defining Incidence, Risk Factors, and Impact on Survival of Central Line-Associated Blood Stream Infections Following Hematopoietic Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome
Central line-associated blood stream infections (CLABSI) commonly complicate the care of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients following allogeneic stem cell transplantation (HCT). We developed a modified CLABSI (MCLABSI) definition which attempts to exclude pathogens usually acquired..Developing a theoretical framework to illustrate associations among patient satisfaction, body image and quality of life for women undergoing breast reconstruction
Cancer Treatment Reviews
Feb 2013
Developing a theoretical framework to illustrate associations among patient satisfaction, body image and quality of life for women undergoing breast reconstruction
Within the field of breast reconstruction there is increasing focus on patient-reported outcomes related to satisfaction, body image, and quality of life. These outcomes are deemed highly relevant because the primary goal of breast reconstruction is to recreate the appearance of a breast (or breasts) that is satisfying..Differences in Birthweight Curves Between Newborns of Immigrant Mothers vs. Infants Born in Their Corresponding Native Countries: Systematic Overview
Paediatric and Perinatal Epidemiology
Feb 2013
Differences in Birthweight Curves Between Newborns of Immigrant Mothers vs. Infants Born in Their Corresponding Native Countries: Systematic Overview
Background: Newborn weight may vary between ethnic groups, but it is not known if birthweight differences exist between term babies born to immigrant mothers compared with those born in their corresponding native countries. Methods: We completed a systematic review of all birthweight curves published between 1980 and..Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia
Biology of Blood and Marrow Transplantation
Feb 2013
Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia
We evaluated the outcome of children and adolescents with acquired severe aplastic anemia (SAA) who received haploidentical hematopoietic stem cell transplantation (HHCT) within vitro T cell-depleted peripheral blood stem cells. Twelve patients with acquired SAA received a total of 15 HHCTs within vitro CD3-depleted..Fish oil attenuates methylmalonate-induced seizures
Epilepsy Research
Feb 2013
Fish oil attenuates methylmalonate-induced seizures
Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures. Dietary fatty acids are known as an important energy source and reduce seizure activity in selected acute animal models. This study investigated whether chronic..Folic acid and vitamin B12 supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: a randomized, double-blind, placebo-controlled trial
Nutrition Research
Feb 2013
Folic acid and vitamin B12 supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: a randomized, double-blind, placebo-controlled trial
An elevated homocysteine level is a newly recognized risk factor for osteoporosis. Older individuals may have elevated homocysteine levels due to inadequate folate intake and/or lower absorption of vitamin B12. The aim of this study was to determine whether there is an impact of folic acid and vitamin B12..Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells
Clinical Nutrition
Feb 2013
Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells
Background & aims: Chemotherapy induces an increase of intestinal permeability that is partially related to an alteration of tight junction proteins, occludin and zonula occludens-1 (ZO-1). Protective effects of glutamine on intestinal barrier function have been previously shown but the effects of other amino acids..High caries prevalence and risk factors among young preschool children in an urban community with water fluoridation
International Journal of Paediatric Dentistry
Feb 2013
High caries prevalence and risk factors among young preschool children in an urban community with water fluoridation
Background: Singapore is unique in that it is a 100% urban community with majority of the population living in a homogeneous physical environment. She, however, has diverse ethnicities and cultures as such; there may be caries risk factors that are unique to this population. Aim: The aims were to assess the oral health..Impact Of Pretransplant Conditioning Regimens On Outcomes Of Allogeneic Transplantation For Chemotherapy-Unresponsisve Diffuse Large B-Cell Lymphoma And Grade-Iii Follicular Lymphoma
Biology of Blood and Marrow Transplantation
Feb 2013
Impact Of Pretransplant Conditioning Regimens On Outcomes Of Allogeneic Transplantation For Chemotherapy-Unresponsisve Diffuse Large B-Cell Lymphoma And Grade-Iii Follicular Lymphoma
Patients with chemorefractory non-Hodgkin lymphomas (NHL) generally have a poor prognosis. We used the observational database of the CIBMTR to study the outcome of 533 patients with refractory diffuse large B-cell lymphoma (DLBCL) or grade-III follicular lymphoma (FL-III) who underwent allogeneic transplantation..Incidence and mortality of breast cancer in China, 2008
Thoracic Cancer
Feb 2013
Incidence and mortality of breast cancer in China, 2008
Background: Female breast cancer incidence and mortality data for the duration of 2008, in China, retrieved from the National Central Cancer Registry, was analyzed. Methods: In 2008, there were 56 registries that submitted cancer registration data. Based on the criteria of data quality, a total of 41 registries' data..Individualized vitamin A supplementation for patients with cystic fibrosis
Clinical Nutrition
Feb 2013
Individualized vitamin A supplementation for patients with cystic fibrosis
Background & aims: To determine the vitamin A status and appropriate supplementation dosage of cystic fibrosis (CF) patients who received vitamin A supplementation based on annual serum retinol measurements. Methods: Vitamin A food intake, supplementation dosage, and serum retinol levels were obtained for 32 CF..Influence of patient characteristics on survival following treatment with helical stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer
Thoracic Cancer
Feb 2013
Influence of patient characteristics on survival following treatment with helical stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer
Background: To determine the influence of patient and tumor characteristics on clinical outcomes in patients with early-stage non-small cell lung cancer (NSCLC) treated with helical intensity modulated stereotactic body radiotherapy (SBRT). Methods: From March 2005 to August 2010 a total of 62 patients with biopsy..Lung cancer incidence and mortality in China, 2008
Thoracic Cancer
Feb 2013
Lung cancer incidence and mortality in China, 2008
Background: To provide cancer statistics to health planners, researchers, and the public, we reported the incidence and mortality data of lung cancer in 2008 in Chinese registration areas by age, sex, and geographic area. Methods: In 2011, 56 population-based cancer registries reported the lung cancer incidence and..Managing Psychosocial Contributors in Low Back Pain Patients—A Randomised Controlled Trial
Journal of Orthopaedics, Trauma and Rehabilitation
Feb 2013
Managing Psychosocial Contributors in Low Back Pain Patients—A Randomised Controlled Trial
Introduction: The efficacy of integrated physiotherapy work rehabilitation program to occupational non-specific low back pain (NSLBP) patients triaged by Orebro Musculoskeletal Pain Questionnaire (OMPQ) for psychosocial risks was investigated. Methods: 47 subjects were recruited and randomly allocated to either the..Merkel cell carcinoma from 2008 to 2012: Reaching a new level of understanding
Cancer Treatment Reviews
Feb 2013
Merkel cell carcinoma from 2008 to 2012: Reaching a new level of understanding
Merkel cell carcinoma (MCC) is a rare primary cutaneous carcinoma of the skin who has high aggressiveness, high risk of locoregional and distant spread, a mortality rate considerably higher than that of cutaneous melanoma and a poor survival. Its incidence has increased during the past twenty years. The studies..nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice
Thoracic Cancer
Feb 2013
nm23-H1 gene driven by hTERT promoter induces inhibition of invasive phenotype and metastasis of lung cancer xenograft in mice
Background: Lung cancer is the leading cause of cancer death in both men and women worldwide. Tumor metastasis is an essential aspect of lung cancer progression and patient death. The nm23-H1 gene has been extensively investigated as a metastasis suppressor gene. Our previous studies have revealed: that a significant..Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Pediatric Blood & Cancer
Feb 2013
Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Background: Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study was to determine genes..Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations
Pediatric Blood & Cancer
Feb 2013
Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations
Background: Familial hemophagocytic lymphohistiocytosis (FHL) is a rare primary immune disorder defined by mutations in the syntaxin binding protein 2 (STXBP2) alias MUNC18-2. Despite defective immunity and a hyper-inflammatory state, clinical findings such as neurological, gastrointestinal, and bleeding disorders are..Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease
Biology of Blood and Marrow Transplantation
Feb 2013
Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease
Pre-engraftment syndrome (PES) is poorly characterized and its clinical significance and the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, we analyzed retrospectively the incidence, risk factors and clinical outcomes of PES in unrelated CBT recipients. Data of..Risk Factors for Acute Respiratory Morbidity in Moderately Preterm Infants
Paediatric and Perinatal Epidemiology
Feb 2013
Risk Factors for Acute Respiratory Morbidity in Moderately Preterm Infants
Background: Infants born preterm account for a substantial part of neonatal morbidity, with acute respiratory disorders being a dominating clinical problem. Whereas focus in recent studies has been on extremely and very preterm infants, less is known about contemporary rates and risk factors for acute respiratory..Safety and efficacy of paclitaxel liposome for elderly patients with advanced non-small cell lung cancer: A multi-center prospective study
Thoracic Cancer
Feb 2013
Safety and efficacy of paclitaxel liposome for elderly patients with advanced non-small cell lung cancer: A multi-center prospective study
Background: Lung cancer in elderly patients poses an increasingly challenge for oncologists. The optimal treatment needs to be explored. The purpose of this study was to evaluate the safety and efficacy of the novel form of paclitaxel liposome for elderly patients with non-small cell lung cancer (NSCLC). Methods: This..Seek and You Shall Find—But Then What Do You Do? Cold Agglutinins in Cardiopulmonary Bypass and a Single-Center Experience With Cold Agglutinin Screening Before Cardiac Surgery
Transfusion Medicine Reviews
Feb 2013
Seek and You Shall Find—But Then What Do You Do? Cold Agglutinins in Cardiopulmonary Bypass and a Single-Center Experience With Cold Agglutinin Screening Before Cardiac Surgery
Cardiopulmonary bypass (CPB) during cardiac surgery can involve deliberate hypothermia of the systemic (22-36°C) and coronary circulations (as low as 8-12°C). Adverse sequelae of cold-active antibodies have been feared and reported under such conditions, and some centers thus elect to screen for cold agglutinins before..Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk
Clinical Oncology
Feb 2013
Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk
The clinical applications of stereotactic body radiotherapy or stereotactic ablative radiotherapy (SABR) for the treatment of primary and metastatic tumours of different organ sites have been expanding rapidly in the recent decade. SABR requires advanced technology in radiotherapy planning and image guidance to deliver..Subcutaneous panniculitis-like T-cell lymphoma in the pediatric age group: A lymphoma of low malignant potential
Pediatric Blood & Cancer
Feb 2013
Subcutaneous panniculitis-like T-cell lymphoma in the pediatric age group: A lymphoma of low malignant potential
Background: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare neoplasm of mature αβ cytotoxic T-cells. Most commonly occurring in young adults, few reports are described in children. A separate analysis of a significant cohort of pediatric patients has not previously been performed. Procedure: We..Targeted therapy in metastatic colorectal cancer – An example of personalised medicine in action
Cancer Treatment Reviews
Feb 2013
Targeted therapy in metastatic colorectal cancer – An example of personalised medicine in action
In metastatic colorectal cancer (mCRC), an improved understanding of the underlying pathology and molecular biology has successfully merged with advances in diagnostic techniques and local/systemic therapies as well as improvements in the functioning of multidisciplinary teams, to enable tailored treatment regimens and..The safety of cefepime and ceftazidime in pediatric oncology patients
Pediatric Blood & Cancer
Feb 2013
The safety of cefepime and ceftazidime in pediatric oncology patients
Background: Concern has been raised about possible increased mortality associated with the use of cefepime. There are limited data available on the pragmatic use of beta-lactam antibiotics, especially in children. Procedure: This retrospective study included 532 pediatric oncology patients. The outcomes of patients..Tracking the source of cerebellar epilepsy: Hemifacial seizures associated with cerebellar cortical dysplasia
Epilepsy Research
Feb 2013
Tracking the source of cerebellar epilepsy: Hemifacial seizures associated with cerebellar cortical dysplasia
Traditionally, subcortical structures such as the cerebellum are supposed to exert a modulatory effect on epileptic seizures, rather than being the primary seizure generator. We report a 14-month old girl presenting, since birth, with seizures symptomatic of a right cerebellar dysplasia, manifested as paroxystic..Whole-body glucose oxidation rate during prolonged exercise in type 1 diabetic patients under usual life conditions
Metabolism
Feb 2013
Whole-body glucose oxidation rate during prolonged exercise in type 1 diabetic patients under usual life conditions
Objective: Fuel oxidation during exercise was studied in type 1 insulin-dependent (T1DM) patients mainly under quite constant insulin and glycemia; these protocols, however, likely do not reflect patients’ usual metabolic conditions. The glucose oxidation rate (GLUox) in T1DM patients under usual life conditions was..Cystatin C and albuminuria as predictors of long-term allograft outcomes in kidney transplant recipients
Clinical Transplantation
Feb 2013
Cystatin C and albuminuria as predictors of long-term allograft outcomes in kidney transplant recipients
Although cystatin C (Cys) and albuminuria (Alb) are predictors of end-stage renal disease in the general population, there are limited data about the performance of these markers alone or combined with respect to the prediction of the kidney transplant outcome. We assessed the ability of one-yr creatinine (Cr), MDRD..Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents
Acta Paediatrica
Feb 2013
Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents
Aim: This study was designed to evaluate the diagnostic value of B-type natriuretic peptide (BNP) in syncope in children and adolescents. Methods: Serum BNP concentration was measured by electrochemiluminescence assay in 62 consecutive children and adolescents hospitalized for syncope. Results: Of the 62 children and..Optimizing arousal to manage aggression: A pilot study of sensory modulation
International Journal of Mental Health Nursing
Feb 2013
Optimizing arousal to manage aggression: A pilot study of sensory modulation
The dominant model that informs clinical training for preventing violence and managing aggression posits arousal as mediated downwards from higher cortical structures. This view results in an often-misplaced reliance on verbal and cognitive techniques for de-escalation. The emergence of sensory modulation, via the Six..AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Feb 2013
AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
Objective: To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods: The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study..Balearic adults have low intakes of fruits and vegetables compared with the dietary guidelines for adults in Spain
Nutrition Research
Feb 2013
Balearic adults have low intakes of fruits and vegetables compared with the dietary guidelines for adults in Spain
Nutrition is recognized as one of the major health determinants, and so a healthy diet may contribute to the delay or prevention of an important number of chronic diseases. The aim of this study was to assess the current food consumption habits of the Balearic Islands adult population. A cross-sectional nutritional..Cancer screening in the United States, 2013
CA: A Cancer Journal for Clinicians
Feb 2013
Cancer screening in the United States, 2013
Each year the American Cancer Society (ACS) publishes a summary of its recommendations for early cancer detection, a report on data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, current ACS cancer screening guidelines are summarized, as are updated..Circulating tumor cells in colorectal cancer patients
Cancer Treatment Reviews
Feb 2013
Circulating tumor cells in colorectal cancer patients
The availability of sensitive methods has allowed the detailed study of circulating tumor cells only recently. Evolving evidence support the prognostic and predictive role of these cells in patients affected by several solid tumors, including colorectal cancer. Ongoing studies are aimed at confirming that the molecular..Diagnostic accuracy of markers for prodromal Alzheimer's disease in independent clinical series
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Feb 2013
Diagnostic accuracy of markers for prodromal Alzheimer's disease in independent clinical series
Objective: To capitalize on data from different clinical series to compare sensitivity and specificity of individual biomarkers for predicting mild cognitive impairment (MCI) progression to Alzheimer's disease (AD). Methods: Medial temporal atrophy, cortical hypometabolism, and cerebrospinal fluid biomarkers were..Disability in atypical parkinsonian syndromes is more dependent on memory dysfunction than motor symptoms
Parkinsonism and Related Disorders
Feb 2013
Disability in atypical parkinsonian syndromes is more dependent on memory dysfunction than motor symptoms
Background: There is a gap in the systematic description and investigation of functional disability in corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). Additionally, the relations between disability, apraxia, cognitive and behavioural changes are not well understood in atypical parkinsonian..Dynamic Change and Impact of Myeloid Derived Suppressor Cells in Allogeneic Bone Marrow Transplantation in Mice
Biology of Blood and Marrow Transplantation
Feb 2013
Dynamic Change and Impact of Myeloid Derived Suppressor Cells in Allogeneic Bone Marrow Transplantation in Mice
Myeloid-derived suppressor cells (MDSCs) are a group of myeloid cells comprised of hematopoietic progenitor cells, immature macrophages, dendritic cells and granulocytes, which accumulate in inflammatory diseases and various cancers. Here, we investigated the dynamic changes and effects of MDSCs in graft-versus-host..Establishing computed tomography–defined visceral fat area thresholds for use in obesity-related cancer research
Nutrition Research
Feb 2013
Establishing computed tomography–defined visceral fat area thresholds for use in obesity-related cancer research
Excess visceral adiposity is associated with increased gastrointestinal cancer risk. Evidence suggests that the systemic inflammation and dysmetabolism observed in visceral obesity underpins this association. Along with magnetic resonance imaging, computed tomography is a gold standard for abdominal fat quantification..Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Feb 2013
Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging
Objective: To evaluate the performance characteristics of florbetapir F18 positron emission tomography (PET) in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy control subjects (HCs). Methods: Florbetapir PET was acquired in 184 subjects (45 AD patients, 60 MCI patients, and 79 HCs)..Focal hemosiderin deposits and β-amyloid load in the ADNI cohort
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Feb 2013
Focal hemosiderin deposits and β-amyloid load in the ADNI cohort
Background: Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD). Methods: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111),..Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome
Nutrition Research
Feb 2013
Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome
Green tea, a popular polyphenol-containing beverage, has been shown to alleviate clinical features of the metabolic syndrome. However, its effects in endogenous antioxidant biomarkers are not clearly understood. Thus, we tested the hypothesis that green tea supplementation will upregulate antioxidant parameters..Improving dementia care: The role of screening and detection of cognitive impairment
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Feb 2013
Improving dementia care: The role of screening and detection of cognitive impairment
The value of screening for cognitive impairment, including dementia and Alzheimer's disease, has been debated for decades. Recent research on causes of and treatments for cognitive impairment has converged to challenge previous thinking about screening for cognitive impairment. Consequently, changes have occurred in..Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures
Epilepsy Research
Feb 2013
Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures
The aim of this study was to assess the anticonvulsant effect of carbon dioxide (CO2) on Scn1a mutation-related febrile seizures. We examined physiological changes in the blood gas levels after the induction of hyperthermia-induced seizures (HISs), which were associated with the Scn1a missense mutation. We determined..New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Feb 2013
New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF
Background: Soluble oligomers of amyloid ß-protein (Aß) have been increasingly linked to synaptic dysfunction, tau alteration, and neuritic dystrophy in Alzheimer's disease (AD) and mouse models. There is a great need for assays that quantify Aß oligomers with high specificity and sensitivity. Methods: We designed and..Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: Pharmacokinetic considerations and clinical implications
Cancer Treatment Reviews
Feb 2013
Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: Pharmacokinetic considerations and clinical implications
Identification of the role of biological pathways in metastatic renal cell carcinoma (mRCC) has led to the development of targeted agents for its treatment, in particular those that inhibit the vascular endothelial growth factor pathway, and inhibitors of mammalian target of rapamycin (mTOR). mTOR is central to..Reduced contribution of executive functions in impaired working memory performance in mild traumatic brain injury patients
Clinical Neurology and Neurosurgery
Feb 2013
Reduced contribution of executive functions in impaired working memory performance in mild traumatic brain injury patients
Aim: Mild traumatic brain injury (MTBI) is associated with often selective impairment of both working memory (WM) and the executive functions (EFs). Research indicates that one of the commonest deficits present in MTBI patients falls in the domain of WM. We aimed to investigate the role of EFs in WM impairment..Sarcopenia: prevalence and prognostic significance in hospitalized patients
Clinical Nutrition
Feb 2013
Sarcopenia: prevalence and prognostic significance in hospitalized patients
Background: Sarcopenia is prevalent in older populations with many causes and varying outcomes however information for use in clinical practice is still lacking. Aims: The aim of this report is to identify the clinical determinants and prognostic significance of sarcopenia in a cohort of hospitalized acutely ill older..Vitamin D metabolism in human bone marrow stromal (mesenchymal stem) cells
Metabolism
Feb 2013
Vitamin D metabolism in human bone marrow stromal (mesenchymal stem) cells
There are many human extra-renal tissues and cells that biosynthesize 1α,25-dihydroxyvitamin D (1α,25(OH)2D) by the action of CYP27B1/1α-hydroxylase. Human marrow stromal cells (hMSCs), also known as mesenchymal stem cells, were isolated from marrow discarded from well-characterized, consented subjects during common..White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Feb 2013
White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment
Background: Current hypothetical models of Alzheimer's disease (AD) pathogenesis emphasize the role of β-amyloid (Aβ), tau deposition, and neurodegenerative changes in the mesial temporal lobe, particularly the entorhinal cortex and hippocampus. However, many individuals with clinical AD who come to autopsy also..Highland Guatemalan women are extremely short of stature, and no lactation duration effects on body composition are observed in a cross-sectional survey
Nutrition Research
Jan 2013
Highland Guatemalan women are extremely short of stature, and no lactation duration effects on body composition are observed in a cross-sectional survey
Early linear growth in Guatemala has historically been compromised, resulting in adults of short stature. We hypothesized that the rate of short stature among mothers in the Western Highlands would have tracked from their own childhood when younger than 5 years, and that maternal weight declines progressively from..Outcomes of related donor HLA-identical or HLA-haploidentical allogeneic blood or marrow transplantation for peripheral T-cell lymphoma
Biology of Blood and Marrow Transplantation
Jan 2013
Outcomes of related donor HLA-identical or HLA-haploidentical allogeneic blood or marrow transplantation for peripheral T-cell lymphoma
Background: The role of allogeneic blood or marrow transplantation (alloBMT) for peripheral T-cell lymphoma (PTCL) remains to be defined. There is growing interest in reduced-intensity conditioning (RIC) regimens and/or utilization of HLA-haploidentical (haplo) grafts given concerns about treatment-associated..Premonitory urges for tics in adult patients with Tourette syndrome
Brain and Development
Jan 2013
Premonitory urges for tics in adult patients with Tourette syndrome
Objective: Patients with Tourette syndrome (TS) often report characteristic sensory experiences, also called premonitory urges (PUs), which precede tic expression and have high diagnostic relevance. This study investigated the usefulness of a scale developed and validated in children and adolescents–the Premonitory..Current practice in diagnosis and treatment of acute graft-versus-host disease – results from a survey among German-Austrian-Swiss HSCT centers
Biology of Blood and Marrow Transplantation
Jan 2013
Current practice in diagnosis and treatment of acute graft-versus-host disease – results from a survey among German-Austrian-Swiss HSCT centers
In order to assess current clinical practice in diagnosis and treatment of acute graft-versus-host disease (aGVHD) we performed a survey among German, Austrian and Swiss allogeneic hematopoietic stem cell transplant (alloHSCT) centers. Thirty-four (47%) of 72 contacted centers completed both the diagnostic and the..Epidemiology and trend of neurological diseases associated to HIV/AIDS. Experience of Mexican patients 1995–2009
Clinical Neurology and Neurosurgery
Jan 2013
Epidemiology and trend of neurological diseases associated to HIV/AIDS. Experience of Mexican patients 1995–2009
Objective: The aim of this study was to identify the main neurological conditions associated with HIV/AIDS in Mexican patients treated at the National Institute of Neurology and Neurosurgery (NINN) in Mexico city, the main referral center for patients with disorders of the central and peripheral nervous system...Genetic expression profiles of adult and pediatric ependymomas: Molecular pathways, prognostic indicators, and therapeutic targets
Clinical Neurology and Neurosurgery
Jan 2013
Genetic expression profiles of adult and pediatric ependymomas: Molecular pathways, prognostic indicators, and therapeutic targets
Ependymomas are tumors that can present within either the intracranial or spinal regions. While 90% of all pediatric ependymomas are intracranial, spinal cord ependymomas are more commonly found in patients 20–40 years old. Treatment for spinal lesions has achieved local control rates up to 100% following gross total..Characteristics of temporal lobe epilepsy with no ictal impairment of consciousness
Clinical Neurology and Neurosurgery
Jan 2013
Characteristics of temporal lobe epilepsy with no ictal impairment of consciousness
Introduction: The predominant manifestations of temporal lobe epilepsy (TLE) are partial seizures with impairment of consciousness (type I.B of ILAE classification), although consciousness impairment is not necessary in all seizures of patients with TLE. Nevertheless, there have been very few reports of TLE patients..Comparison of 5% versus 15% sucrose intakes as part of a eucaloric diet in overweight and obese subjects: Effects on insulin sensitivity, glucose metabolism, vascular compliance, body composition and lipid profile. A Randomised Controlled Trial
Metabolism
Jan 2013
Comparison of 5% versus 15% sucrose intakes as part of a eucaloric diet in overweight and obese subjects: Effects on insulin sensitivity, glucose metabolism, vascular compliance, body composition and lipid profile. A Randomised Controlled Trial
Aims: The effect of dietary sucrose on insulin resistance and the pathogenesis of diabetes and vascular disease is unclear. We assessed the effect of 5% versus 15% sucrose intakes as part of a weight maintaining, eucaloric diet in overweight/obese subjects. Methods: Thirteen subjects took part in a randomised..Ketamine use in the treatment of refractory status epilepticus
Epilepsy Research
Jan 2013
Ketamine use in the treatment of refractory status epilepticus
Refractory status epilepticus (RSE) occurs when status epilepticus (SE) fails to respond to appropriate therapy with typical antiepileptic drugs (AEDs). Animal studies have shown ketamine to be a highly efficacious agent in this setting, but very few case reports describe use of ketamine in human SE or RSE. We report a..Nocturnal carbon dioxide monitoring in patients with idiopathic intracranial hypertension
Clinical Neurology and Neurosurgery
Jan 2013
Nocturnal carbon dioxide monitoring in patients with idiopathic intracranial hypertension
Background: Idiopathic intracranial hypertension may be associated with sleep apnea. This study evaluated the incidence of sleep breathing disorders in patients with idiopathic intracranial hypertension. Materials and Methods: Overnight respiratory monitoring was performed in 22 untreated patients with idiopathic..Manifestations of interpersonal dependency and depressive subtypes in outpatient psychotherapy patients
Personality and Mental Health
Jan 2013
Manifestations of interpersonal dependency and depressive subtypes in outpatient psychotherapy patients
The present study investigated the relationship between normative and pathological dependency and anaclitic and introjective depressive experiences among 71 patients participating in outpatient psychotherapy at a university-based psychology clinic. We examined the interrelationships among the Relationship Profile Test..A cost effectiveness analysis of stepped care treatment for bulimia nervosa
International Journal of Eating Disorders
Jan 2013
A cost effectiveness analysis of stepped care treatment for bulimia nervosa
Background: The cost effectiveness of various treatment strategies for bulimia nervosa (BN) is unknown. Aims: To examine the cost effectiveness of stepped care treatment for BN. Method: Randomized trial conducted at four clinical centers with intensive measurement of direct medical costs and repeated measurement of..A rat in the labyrinth of anorexia nervosa: Contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa
International Journal of Eating Disorders
Jan 2013
A rat in the labyrinth of anorexia nervosa: Contributions of the activity-based anorexia rodent model to the understanding of anorexia nervosa
Activity-based anorexia (ABA) is an analogous animal model of anorexia nervosa where food-restricted rats develop excessive running activity when given free access to a running wheel; their body weight sharply decreases, and finally self-starvation and death ensue unless animals are removed from the experimental..Abducted by the illness: A qualitative study of traumatic stress in individuals with acute leukemia
Leukemia Research
Jan 2013
Abducted by the illness: A qualitative study of traumatic stress in individuals with acute leukemia
Symptoms of traumatic stress are common in acute leukemia. The goal of the present qualitative study was to understand this traumatic stress, as perceived by patients. Participants were 43 patients with acute leukemia in Toronto, Canada. Participants were asked in serial interviews about their experience of diagnosis..Cellular mechanisms regulating fuel metabolism in mammals: Role of adipose tissue and lipids during prolonged food deprivation
Metabolism
Jan 2013
Cellular mechanisms regulating fuel metabolism in mammals: Role of adipose tissue and lipids during prolonged food deprivation
Food deprivation in mammals results in profound changes in fuel metabolism and substrate regulation. Among these changes are decreased reliance on the counter-regulatory dynamics by insulin-glucagon due to reduced glucose utilization, and increased concentrations of lipid substrates in plasma to meet the energetic..Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia
Journal of Psychiatric Research
Jan 2013
Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia
Background: Schizophrenia (SZ) has been associated with an imbalance in the inflammatory cytokine TNF-α. The objectives of this study were to compare TNF-α and its soluble receptors' serum levels in individuals with SZ with the levels found in a group of healthy volunteers and to investigate the possible association..Clinical and neurocognitive markers of suicidality in young adults
Journal of Psychiatric Research
Jan 2013
Clinical and neurocognitive markers of suicidality in young adults
Background: Suicide represents a leading cause of death in young people, yet relatively little is known regarding the neurobiological sequelae of preceding suicidal thoughts and behaviours. Although some studies have reported cognitive deficits associated with suicidality, very few studies have been undertaken in young..Concurrent chemoradiotherapy for large-volume locally-advanced non-small cell lung cancer
Lung Cancer
Jan 2013
Concurrent chemoradiotherapy for large-volume locally-advanced non-small cell lung cancer
Purpose: Patients with large volume stage III non-small cell lung cancer (NSCLC) are often excluded from concurrent chemoradiotherapy (CRT) protocols due to fears about excessive toxicity and poor survival. Patients with N3 nodal disease may be excluded for the same reason. We have routinely accepted fit patients in..Dietary sodium intake and prevalence of overweight in adults
Metabolism
Jan 2013
Dietary sodium intake and prevalence of overweight in adults
Objective: There has been no convincing evidence for a direct relation between sodium intake and being overweight. Therefore, we investigated the independent relationship between overweight and sodium intake in human subjects. Methods: Of those aged 19 to 64years who participated in the 4th Korea National Health and..Does CA125 binding to mesothelin impact the detection of malignant mesothelioma?
Lung Cancer
Jan 2013
Does CA125 binding to mesothelin impact the detection of malignant mesothelioma?
The biomarker mesothelin is a useful diagnostic tool in malignant mesothelioma (MM) patients. It has high specificity but a sensitivity of only 50%. As mesothelin binds CA125, and as CA125 is often elevated in MM, we asked whether this binding affected measurable mesothelin levels in a relevant clinical setting...Effects of anesthetic agents on seizure-induction with intra-cortical injection of convulsants
Epilepsy Research
Jan 2013
Effects of anesthetic agents on seizure-induction with intra-cortical injection of convulsants
Rationale: Studies of partial or generalized seizure pathophysiology often require the use of intact animals. Additionally, anesthesia may be required for ethical reasons or paralysis if instrumental measures require immobilization. We examined three commonly used injected anesthetic for their impact on seizures..Evaluation of glycated hemoglobin and fetal hemoglobin-adjusted HbA1c measurements in infants
Pediatric Diabetes
Jan 2013
Evaluation of glycated hemoglobin and fetal hemoglobin-adjusted HbA1c measurements in infants
Background: As the presence of fetal hemoglobin (HbF) affects the accuracy of hemoglobin A1c (HbA1c) analysis methods, HbA1c measurement may not be a good indicator for patients with neonatal diabetes mellitus, whereas glycated albumin (GA) may be a good indicator. Objective: To investigate whether total glycated..Executive function in eating disorders: The role of state anxiety
International Journal of Eating Disorders
Jan 2013
Executive function in eating disorders: The role of state anxiety
Objective: We examined the influence of depression and anxiety on executive function in individuals with a DSM-IV diagnosis of anorexia nervosa-restricting type, anorexia nervosa-binge-eating/purging type, bulimia nervosa, or eating disorder not otherwise specified. Method: We assessed 106 women after their inpatient..Exogenous insulin requirements do not differ between youth and adults with cystic fibrosis related diabetes
Pediatric Diabetes
Jan 2013
Exogenous insulin requirements do not differ between youth and adults with cystic fibrosis related diabetes
Objective: To examine whether insulin requirements and diabetes control differ between adolescents and adults with cystic fibrosis related diabetes (CFRD). Methods: All CFRD patients on insulin therapy seen at the University of Minnesota outpatient clinic from 1 January 2011 to 1 June 2012 were identified. Hemoglobin..Expression of p27Kip1, a cell cycle repressor protein, is inversely associated with potential carcinogenic risk in the genetic rodent models of obesity and long-lived Ames dwarf mice
Metabolism
Jan 2013
Expression of p27Kip1, a cell cycle repressor protein, is inversely associated with potential carcinogenic risk in the genetic rodent models of obesity and long-lived Ames dwarf mice
Introduction: The association of genetic rodent models of obesity and cancer still remains a controversial issue. Although this controversy has largely been resolved in recent years for homozygous leptin receptor-deficient obese Zucker rats and homozygous long-lived Ames dwarf mice, it is still unresolved for..Familial hypercholesterolemia affects microvascular autoregulation in children
Metabolism
Jan 2013
Familial hypercholesterolemia affects microvascular autoregulation in children
Objective: Familial hypercholesterolemia (FH) impairs macrovascular endothelial function in childhood and causes an increase of cardiovascular risk in later life. Whether microvascular function is affected in children with FH is unknown. The aim of this study was to investigate the impact of FH on microvascular..Farletuzumab in lung cancer
Lung Cancer
Jan 2013
Farletuzumab in lung cancer
Folate is essential for proliferating cells and folate transport pathways and folate-dependent metabolic processes show promise as targets for anti-neoplastic therapy. Folate receptor α (FOLR1), a folate transporter, is an attractive target for anti-neoplastic therapy due to its high affinity for folate, restricted..High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
Leukemia Research
Jan 2013
High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m2 q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-risk..Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?
The Prostate
Jan 2013
Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?
Background: Advanced prostate cancer is treated by hormone ablation therapy. However, despite an initial response, the majority of men relapse to develop castration-resistant disease for which there are no effective treatments. We have previously shown that manipulating individual proteins has only minor alterations on..Ketogenic diet for infantile spasms refractory to first-line treatments: An open prospective study
Epilepsy Research
Jan 2013
Ketogenic diet for infantile spasms refractory to first-line treatments: An open prospective study
Ketogenic diet (KD) is an efficient treatment for refractory epilepsy including infantile spasms (IS). We evaluated the effect of a KD to treat IS as a third-line treatment, after vigabatrin (VGB) and steroids. We evaluated the efficacy and the tolerability of KD in IS using the rate of seizure-free patients at 1..Microsurgical clipping of previously coiled intracranial aneurysms
Clinical Neurology and Neurosurgery
Jan 2013
Microsurgical clipping of previously coiled intracranial aneurysms
Objective: Endovascular coiling techniques for the treatment of intracranial aneurysms have rapidly developed as an alternative option to surgical clipping. A distinct problem after endovascular coiling is the management of a residual aneurysm neck due to incomplete filling, compaction of coils or regrowth of the..Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy
Epilepsy Research
Jan 2013
Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy
It has been suggested that loss of the astrocytic water channel aquaporin-4 (AQP4) from perivascular endfeet in sclerotic hippocampi contributes to increased seizure propensity in human mesial temporal lobe epilepsy (MTLE). Whether this loss occurs prior to or as a consequence of epilepsy development remains to be..MRI findings after hyperbaric oxygen-induced seizures
Epilepsy Research
Jan 2013
MRI findings after hyperbaric oxygen-induced seizures
Hyperbaric oxygen-induced seizures are classified as generalized, tonic-clonic seizures. They are believed to cause no residual neurologic damage, although this has not been investigated in depth. We used different MRI sequences to determine whether hyperbaric oxygen-induced seizures in mice caused brain structural..Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients
Lung Cancer
Jan 2013
Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients
Lung adenocarcinoma is the most common type of primary lung cancer. The purpose of this study was to delineate gene expression patterns for survival prediction in lung adenocarcinoma. Gene expression profiles of 82 (discovery set) and 442 (validation set 1) lung adenocarcinoma tumor tissues were analyzed using a..Renin Inhibition and AT1R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling
Metabolism
Jan 2013
Renin Inhibition and AT1R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling
Objective: Strategies that block angiotensin II actions on its angiotensin type 1 receptor or inhibit actions of aldosterone have been shown to reduce myocardial hypertrophy and interstitial fibrosis in states of insulin resistance. Thereby, we sought to determine if combination of direct renin inhibition with..Rituximab Maintenance Therapy Until Progression After Rituximab and Chemotherapy Induction in Patients With Follicular Lymphoma
Clinical Lymphoma Myeloma and Leukemia
Jan 2013
Rituximab Maintenance Therapy Until Progression After Rituximab and Chemotherapy Induction in Patients With Follicular Lymphoma
Introduction The PRIMA (Primary Rituximab and Maintenance) study established 2 years of maintenance rituximab (MR) as a standard of care for follicular lymphoma (FL) patients who achieve an objective response after induction chemotherapy. A 17% improvement in progression-free survival (PFS) compared with those who did..Sex differences in health-related quality of life impairment associated with eating disorder features: A general population study
International Journal of Eating Disorders
Jan 2013
Sex differences in health-related quality of life impairment associated with eating disorder features: A general population study
Objective: To determine sex differences in the prevalence and impact of specific eating disorder features on health-related quality of life (HRQoL). Method: A general population sample of men (n = 1,479) and women (n = 1,555) completed interviews that assessed HRQoL (Medical Outcomes Study Short Form, SF-36), and..Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
Leukemia Research
Jan 2013
Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
Background: Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and..The involvement of 5-lipoxygenase activating protein in anxiety-like behavior
Journal of Psychiatric Research
Jan 2013
The involvement of 5-lipoxygenase activating protein in anxiety-like behavior
The 5-lipoxygenase is an enzyme widely expressed in the central nervous system, where its activity is dependent on the presence the 5-lipoxygenase activating protein (FLAP) for the formation of leukotrienes, potent bioactive lipid mediators. Emerging evidence has shown that the FLAP/leukotriene pathway may play a role..Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q)
Cancer Genetics
Jan 2013
Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q)
The isolated deletion of chromosome 20q [del(20q)] has been observed in both de novo and therapy-related cases of myelodysplastic syndrome (MDS). The clinicopathologic features of de novo MDS with isolated del(20q) are well characterized. However, relatively little is known about therapy-related myeloid neoplasms..White matter integrity is reduced in bulimia nervosa
International Journal of Eating Disorders
Jan 2013
White matter integrity is reduced in bulimia nervosa
Objective: To investigate brain white matter (WM) functionality in bulimia nervosa (BN) in relation to anxiety. Method: Twenty-one control women (CW, mean age 27 ± 7 years) and 20 BN women (mean age 25 ± 5 years) underwent brain diffusion tensor imaging to measure fractional anisotropy (FA; an indication of WM axon..A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer
Cancer Genetics
Jan 2013
A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer
Since the identification of the TMPRSS2-ERG rearrangement as the most common fusion event in prostate cancer, various methods have been developed to detect this rearrangement and to study its prognostic significance. We report a novel four-color fluorescence in situ hybridization (FISH) assay that detects not only the..A randomised trial of fluticasone furoate/vilanterol (50/25 μg; 100/25 μg) on lung function in COPD
Respiratory Medicine
Jan 2013
A randomised trial of fluticasone furoate/vilanterol (50/25 μg; 100/25 μg) on lung function in COPD
Background: Fluticasone furoate (FF)/vilanterol (VI) is a novel once-daily inhaled corticosteroid/long-acting β2-agonist combination therapy for COPD. We aimed to assess the efficacy and safety of two strengths of FF/VI (100/25 μg; 50/25 μg) vs. individual components (FF 100 μg, VI 25 μg) and placebo over 24 weeks...Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: Systematic review and meta-analysis of the literature
Lung Cancer
Jan 2013
Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: Systematic review and meta-analysis of the literature
Background: Not all patients with non-small cell lung carcinoma (NSCLC) have mediastinal lymph node involvement and development of less invasive methods for evaluating mediastinal lymph nodes is important. Sentinel node biopsy has been used for NSCLC since 1999 to decrease the need for mediastinal lymph node..Bronchiolitis in young female smokers
Respiratory Medicine
Jan 2013
Bronchiolitis in young female smokers
Background: Smoking is a growing concern among young women. However, the pulmonary effects of smoking in young female smokers in their 20's are unknown. Objective: The purpose of this study was to determine whether young female smokers demonstrate smoking-related lung abnormalities such as bronchiolitis in their 20's...Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation
Respiratory Medicine
Jan 2013
Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation
Aim: Lung function tests are essential for the diagnosis and management of bronchial asthma. Impulse oscillation (IOS) system is an alternative way to measure lung mechanics for some patients. We investigated the relative sensitivities of IOS, body plethysmography and spirometry in detecting allergen- and..Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer
Lung Cancer
Jan 2013
Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer
Lung cancer is sometimes difficult to differentiate from benign lung diseases expressing nodular shadow in imaging study. We assessed the diagnostic value of two commonly used tumor markers in distinguishing primary lung cancer from benign lung disease. The serum levels of carcinoembryonic antigen (CEA) and cytokeratin..Differentiation of pure vasogenic edema and tumor-infiltrated edema in patients with peritumoral edema by analyzing the relationship of axial and radial diffusivities on 3.0T MRI
Clinical Neurology and Neurosurgery
Jan 2013
Differentiation of pure vasogenic edema and tumor-infiltrated edema in patients with peritumoral edema by analyzing the relationship of axial and radial diffusivities on 3.0T MRI
Object: The purpose of this study was to analyze the relationship of axial diffusivity (AD) and radial diffusivity (RD) in peritumoral edema of high grade glioma, metastasis, and meningioma, and to differentiate tumor-infiltrated edema from pure vasogenic edema. Materials and methods: Twenty patients with high-grade..Improved glycemic control and acute complications among children with type 1 diabetes mellitus in Moshi, Tanzania
Pediatric Diabetes
Jan 2013
Improved glycemic control and acute complications among children with type 1 diabetes mellitus in Moshi, Tanzania
Objective: There are an estimated 1000 children with diabetes in Tanzania. Recently, the first two pediatric endocrinologists, trained in the European Society for Paediatric Endocrinology (ESPE)/International Society for Paediatric and Adolescent Diabetes (ISPAD) program in Nairobi, Kenya, entered practice. The purpose..Interventions for impaired bladders in paediatric renal transplant recipients with lower urinary tract dysfunction
Transplant International
Jan 2013
Interventions for impaired bladders in paediatric renal transplant recipients with lower urinary tract dysfunction
Dysfunctional bladders in paediatric patients were thought to be a contraindication for renal transplantation, but advances in surgical techniques have meant that surgical correction can allow safe transplantation. This study compares the outcomes of renal transplantation for different interventions, and the timing of..Maternal depressive symptoms predict acute hospitalization among children with type 1 diabetes
Pediatric Diabetes
Jan 2013
Maternal depressive symptoms predict acute hospitalization among children with type 1 diabetes
Objectives: The aim of this study is to examine the impact of a mother's depressive symptoms on the risk of hospital admission of her child due to severe hypoglycemia or diabetic ketoacidosis. Materials and methods: One hundred sixty-six mothers of children with type 1 diabetes (T1DM) were evaluated using the Hamilton..Midcarpal Joint Loose Body, Where Does It Come from?
Journal of Orthopaedics, Trauma and Rehabilitation
Jan 2013
Midcarpal Joint Loose Body, Where Does It Come from?
We report a case of intra-articular loose body in the mid-carpal joint following the fracture of the distal radius. The patient fell from a height of 5 ft. The radiographs and computed tomography scan showed a bony fragment in the midcarpal joint. It was associated with dorsal scapholunate ligament tear. The..Partial seizures during ACTH therapy in a cryptogenic West syndrome patient
Brain and Development
Jan 2013
Partial seizures during ACTH therapy in a cryptogenic West syndrome patient
Background: Partial seizures often develop during the clinical course of infantile spasms. Herein, we report a boy with cryptogenic West syndrome, who developed partial seizures that we suspected were induced by the ACTH therapy. Subject: The patient developed cryptogenic West syndrome at six months of age and ACTH..Prediction of early allograft dysfunction using serum phosphorus level in living donor liver transplantation
Transplant International
Jan 2013
Prediction of early allograft dysfunction using serum phosphorus level in living donor liver transplantation
Serum phosphorus is greatly affected by liver surgeries, but its change after liver transplantation has not yet been clarified. We investigated the predictive role of serum phosphorus for early allograft dysfunction (EAD) after living donor liver transplantation (LDLT). Perioperative factors, including serum phosphorus..Preventing COPD exacerbations with macrolides: A review and budget impact analysis
Respiratory Medicine
Jan 2013
Preventing COPD exacerbations with macrolides: A review and budget impact analysis
Long-term treatment with macrolides has recently been shown to reduce COPD exacerbations in doses lower than bactericidal doses. This article aims to critically review the international literature relating to the long-term effectiveness and safety of macrolides and to estimate the budget impact of preventing..Readmissions for COPD: propensity case-matched comparison between pulmonary and non-pulmonary departments
The Clinical Respiratory Journal
Jan 2013
Readmissions for COPD: propensity case-matched comparison between pulmonary and non-pulmonary departments
Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common cause of hospitalization, and the readmission rate is high. We aimed to determine whether patients discharged from a pulmonary department (PD) after an AECOPD episode had a lower COPD-related readmission rate during the next..Reliability of EGFR and KRAS mutation analysis on fine-needle aspiration washing in non-small cell lung cancer
Lung Cancer
Jan 2013
Reliability of EGFR and KRAS mutation analysis on fine-needle aspiration washing in non-small cell lung cancer
Introduction: Molecular profiling of advanced non-small cell lung cancer (NSCLC) has become essential for predicting customized medical treatment decision. In light of recent advances in non-invasive diagnostic procedures in NSCLC, we aimed to demonstrate the reliability of assessing molecular tests for epidermal..Systemic corticosteroids for community-acquired pneumonia: Reasons for use and lack of benefit on outcome
Respirology
Jan 2013
Systemic corticosteroids for community-acquired pneumonia: Reasons for use and lack of benefit on outcome
Background and Objective: Although the benefits of systemic corticosteroids in community-acquired pneumonia (CAP) are not clear, their use is frequent in clinical practice. We described the frequency of this practice, patients' characteristics and its clinical impact. Methods: We investigated all adult CAP patients..Transcapsular arterial neovascularization of liver transplants increases the risk of intraoperative bleeding during retransplantation
Transplant International
Jan 2013
Transcapsular arterial neovascularization of liver transplants increases the risk of intraoperative bleeding during retransplantation
Arterial neovascularization of liver grafts can be a source of significant blood loss during retransplantation. This study evaluated the effect of transcapsular arterial neovascularization on intraoperative blood loss during retransplantation and long-term follow-up. Eleven consecutive patients with transcapsular..3D culture model to distinguish normal from malignant human bronchial epithelial cells
European Respiratory Journal
Jan 2013
3D culture model to distinguish normal from malignant human bronchial epithelial cells
In the present study, we have developed an in vitro three-dimensional (3D) model to differentiate normal from lung cancer cells in order to study the mechanisms resulting in lung cancer. Using a reconstituted laminin-rich basement membrane (Matrigel), we were able to culture normal human bronchial epithelial cells..Airway and systemic inflammation in obese children with asthma
European Respiratory Journal
Jan 2013
Airway and systemic inflammation in obese children with asthma
Obese asthma presents via altered airway and systemic inflammation in adults. This has not been comprehensively described in children. To compare airway and systemic inflammation in obese and non-obese asthmatic children and controls. In a cross-sectional study, children aged 8–17 yr were assigned to one of four..Biomarker-enhanced triage in respiratory infections – a proof-of-concept feasibility trial
European Respiratory Journal
Jan 2013
Biomarker-enhanced triage in respiratory infections – a proof-of-concept feasibility trial
Concerns about inadequate performance and complexity limit routine use of clinical risk scores in lower respiratory tract infections (LRTIs). Our aim was to study feasibility and effects of adding the biomarker proadrenomedullin (ProADM) to the CURB65 score on triage decisions and length of stay (LOS). In a randomised..Decline in incidence of HIV and Hepatitis C virus infection among injecting drug users in Amsterdam; evidence for harm reduction?
Addiction
Jan 2013
Decline in incidence of HIV and Hepatitis C virus infection among injecting drug users in Amsterdam; evidence for harm reduction?
Aims: In Amsterdam HIV prevalence has nearly halved among Injecting Drug Users (IDU) since 1990. Hepatitis C Virus (HCV) prevalence also declined, HIV and HCV incidence dropped to nearly zero. We examined possible explanations for these time trends, among which the implementation of harm reduction measures aimed at..Differences in resting corticolimbic functional connectivity in bipolar I euthymia
Bipolar Disorders
Jan 2013
Differences in resting corticolimbic functional connectivity in bipolar I euthymia
Objective: We examined resting state functional connectivity in the brain between key emotion regulation regions in bipolar I disorder to delineate differences in coupling from healthy subjects. Methods: Euthymic subjects with bipolar I disorder (n = 20) and matched healthy subjects (n = 20) participated in a resting..Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria
Leukemia Research
Jan 2013
Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria
Hairy cell leukemia (HCL) and hairy cell leukemia-variant (HCL-v) are rare diseases with overlapping clinico-pathological features. We performed flow cytometry analysis (FCM) of 213 cases (169 HCL, 35 HCL-v, 9 splenic marginal zone lymphoma (SMZL)), correlating results with available corresponding clinical and..Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults
Metabolism
Jan 2013
Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults
Objective: Olive oil (OO) is a rich source of monounsaturated fat and bioactive components that exert strong anti-oxidant and anti-inflammatory properties. Flaxseed oil (FO) is rich in α-linolenic n-3 fatty acid (ALA), which also exhibits anti-inflammatory effects. This randomized, cross-over study aimed at exploring..Global alcohol exposure estimates by country, territory and region for 2005 – a contribution to the Comparative Risk Assessment for the 2010 Global Burden of Disease Study
Addiction
Jan 2013
Global alcohol exposure estimates by country, territory and region for 2005 – a contribution to the Comparative Risk Assessment for the 2010 Global Burden of Disease Study
Aims: This study aimed to estimate the prevalence of lifetime abstainers, former drinkers and current drinkers, adult per capita consumption of alcohol, and pattern of drinking scores, by country and Global Burden of Disease region for 2005, and to forecast these indicators for 2010. Design: Statistical modelling based..Image guidance to improve reliability and data integrity of transcranial Doppler sonography
Clinical Neurology and Neurosurgery
Jan 2013
Image guidance to improve reliability and data integrity of transcranial Doppler sonography
Background: Principles and accuracy of image-guided transcranial Doppler (IG TCD) sonography have been published recently. However, it remains open whether combination of image guidance and TCD offers an additional clinical advantage. This study scores the accuracy of conventional TCD examinations and investigates the..Improved transplantation outcome through delivery of DNA encoding secretion signal peptide-linked glucagon-like peptide-1 into mouse islets
Transplant International
Jan 2013
Improved transplantation outcome through delivery of DNA encoding secretion signal peptide-linked glucagon-like peptide-1 into mouse islets
Glucagon-like peptide-1 (GLP-1) stimulates cell proliferation and has anti-apoptotic effects on pancreatic islet β cells. In our previous study, the transduction of mouse islets with a recombinant adenovirus containing GLP-1 cDNA enhanced islet graft survival. In this study, we sought to deliver the GLP-1 gene using a..Is immune escape via human leukocyte antigen expression clinically relevant in chronic lymphocytic leukemia? Focus on the controversies
Leukemia Research
Jan 2013
Is immune escape via human leukocyte antigen expression clinically relevant in chronic lymphocytic leukemia? Focus on the controversies
Changes in classical and non-classical human leukocyte antigen expression by tumor cells can play a critical role in the generation of tumor antigen-specific immune responses and can modulate the interactions of natural killer cells and T cell subpopulations with target cells. Recently, several studies have..Isolated brainstem cysticercosis: A review
Clinical Neurology and Neurosurgery
Jan 2013
Isolated brainstem cysticercosis: A review
Objective: Review of patients with isolated brainstem cysticercus to outline the features of this form of neurocysticercosis. Methods: MEDLINE and manual search of patients with isolated brainstem cysticercus. Abstracted data included: demographic profile, clinical manifestations, neuroimaging findings, evolutive stage..Liver transplantation for urea cycle disorders in pediatric patients: A single-center experience
Pediatric Transplantation
Jan 2013
Liver transplantation for urea cycle disorders in pediatric patients: A single-center experience
LT has emerged as a surgical treatment for UCDs. We hypothesize that LT can be safely and broadly utilized in the pediatric population to effectively prevent hyperammonemic crises and potentially improve neurocognitive outcomes. To determine the long-term outcomes of LT for UCDs, charts of children with UCD who..Parental refusal of vaccination and transplantation listing decisions: A nationwide survey
Pediatric Transplantation
Jan 2013
Parental refusal of vaccination and transplantation listing decisions: A nationwide survey
Many professional societies and research studies recommend complete vaccination before pediatric solid organ transplantation. Nevertheless, incompletely vaccinated children often receive transplants. As the number of parents refusing to vaccinate children for nonmedical reasons increases, pediatric transplantation..The impact of child sexual abuse on the course of bipolar disorder: a systematic review
Bipolar Disorders
Jan 2013
The impact of child sexual abuse on the course of bipolar disorder: a systematic review
Objectives: The aim of this review was to elucidate the impact of child sexual abuse on all clinical phenomena that occur after the onset of bipolar disorder, including associated clinical features that are not part of the diagnostic criteria for the disorder. Methods: Five databases were searched and supplemented with..The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children
Pediatric Diabetes
Jan 2013
The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children
Background: Nesfatin-1, a recently discovered anorexigenic neuropeptide, is expressed in several tissues including pancreatic islet cells and central nervous system. This peptide seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis. Objective: We aimed to investigate..A case of neonatal human parechovirus encephalitis with a favourable outcome
Brain and Development
Jan 2013
A case of neonatal human parechovirus encephalitis with a favourable outcome
Human parechoviruses (HPeVs) are a new family of neurotropic viruses that cause central nervous system (CNS) infections similar to enterovirus (EVs) meningoencephalitis in the neonatal period, resulting in white matter lesions that can be visualized with cranial ultrasonography and magnetic resonance imaging, and..Mental healthcare efforts for the public after the Great East Japan Earthquake: “Guide to Good Mental Health for Those Affected by Natural Disasters” published by the Cabinet Office
Brain and Development
Jan 2013
Mental healthcare efforts for the public after the Great East Japan Earthquake: “Guide to Good Mental Health for Those Affected by Natural Disasters” published by the Cabinet Office
One year after the Great East Japan Earthquake, the Office of Policy for Suicide Prevention of the Cabinet Office published and distributed three stages of pamphlets under the supervision of the National Center of Neurology and Psychiatry, promoting understanding about mental healthcare for those affected by natural..Erectile dysfunction in heart failure patients: a critical reappraisal
Andrology
Jan 2013
Erectile dysfunction in heart failure patients: a critical reappraisal
Heart failure (HF) is a complex clinical syndrome with a constantly increasing incidence and prevalence in western countries. Total absence of sexual activity is registered in 30% of HF patients. Moreover, HF-induced reduction in exercise tolerance, side effects of HF medications and the coexistence of shared risk..Protocol for the perfusion and angiography imaging sub-study of the Third International Stroke Trial (IST-3) of alteplase treatment within six-hours of acute ischemic stroke
International Journal of Stroke
Jan 2013
Protocol for the perfusion and angiography imaging sub-study of the Third International Stroke Trial (IST-3) of alteplase treatment within six-hours of acute ischemic stroke
Rationale: Intravenous thrombolysis with recombinant tissue Plasminogen Activator improves outcomes in patients treated early after stroke but at the risk of causing intracranial hemorrhage. Restricting recombinant tissue Plasminogen Activator use to patients with evidence of still salvageable tissue, or with definite..Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria
Cancer Letters
Jan 2013
Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria
Failure of anti-cancer therapy in colorectal cancer (CRC) cells involves resistance to death mechanisms. We investigated grape seed extract (GSE) ability to target CRC cells and delineated the mechanisms involved in GSE-induced CRC cell death. GSE selectively induced apoptotic death in human CRC cells; efficacy..Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification
Bone
Jan 2013
Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification
The role of Wnt signaling is extensively studied in skeletal development and postnatal bone remodeling, mostly based on the genetic approaches of β-catenin manipulation. However, given their independent function, a requirement for β-catenin is not the same as that for Wnt. Here, we investigated the effect of Wnt..Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy
BJU International
Jan 2013
Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy
What's known on the subject? and What does the study add? It is known that a prostate cancer gene 3 (PCA3) urine assay is superior to serum PSA level or PSA-related indices for predicting a positive biopsy result in European and US men. This is the first report on PCA3 in a large cohort of Japanese men. The diagnostic..Current status of long-term indwelling urinary catheter management by visiting nurses
International Journal of Urological Nursing
Jan 2013
Current status of long-term indwelling urinary catheter management by visiting nurses
Patients with indwelling catheters at home are more likely to receive home-visit nursing care. However, the condition of patients with indwelling catheters among those receiving home-visit nursing care, as well as the actual status of catheter management practised by visiting nurses, has not been studied. The aim of..Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma
Cancer Letters
Jan 2013
Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma
Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor prognosis. Current standard treatment includes chemotherapy using DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. However, GBM patients exhibit various levels of the elevated expression of..Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
Cancer Letters
Jan 2013
Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
Phytochemicals are well known to have cancer chemopreventive effects by induction of phase II detoxification enzymes including quinone reductase (NQO-1) and glutathione-S-transferases. These detoxification enzymes are commonly regulated by nuclear factor-E2 (Nrf2), which is a representative antioxidant and..Perioperative Complications and Mortality After Radical Cystectomy When Using a Standardized Reporting Methodology
Clinical Genitourinary Cancer
Jan 2013
Perioperative Complications and Mortality After Radical Cystectomy When Using a Standardized Reporting Methodology
Purpose: To evaluate, by using a standardized reporting methodology, the perioperative complications and mortality in patients who underwent radical cystectomy. Materials and Methods: We retrospectively reviewed all data of 404 consecutive patients who underwent radical cystectomy from 1995 to 2009 for nonmetastatic..Role of Conventional Chemosensitivity Test and Tissue Biomarker Expression in Predicting Response to Treatment of Peritoneal Carcinomatosis From Colon Cancer
Clinical Colorectal Cancer
Jan 2013
Role of Conventional Chemosensitivity Test and Tissue Biomarker Expression in Predicting Response to Treatment of Peritoneal Carcinomatosis From Colon Cancer
Background: 5-Fluorouracil- or oxaliplatin-based regimens are the treatments of choice in patients with PC from colon cancer. There are currently no useful preclinical evaluations to guide the decision-making process for tailored therapy. The aim of the present study was to compare the advantages and limits of a..Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to standardize protocols?
BJU International
Jan 2013
Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to standardize protocols?
What's known on the subject? and What does the study add?The topic of radiation safety has been hotly debated not only in the mainstream media, but also in the urological literature. Radiation exposure has been examined in urological diseases such as testicular cancer and urinary stone disease, with resultant..A New Method to Quantify Male Pelvic Floor Displacement From 2D Transperineal Ultrasound Images
Urology
Jan 2013
A New Method to Quantify Male Pelvic Floor Displacement From 2D Transperineal Ultrasound Images
Objective: To develop a method to quantify displacement of pelvic structures during contraction of the pelvic floor muscles from transperineal ultrasound images in men and investigate the reliability of the method between days. Methods: Ten healthy male volunteers (aged 28–41 years) attended 2 separate data collection..A novel canine model for prostate cancer
The Prostate
Jan 2013
A novel canine model for prostate cancer
Background: No existing animal model fully recapitulates all features of human prostate cancer. The dog is the only large mammal, besides humans, that commonly develops spontaneous prostate cancer. Canine prostate cancer features many similarities with its human counterpart. We sought to develop a canine model of..A novel tool to assess the risk of urinary incontinence after nerve-sparing radical prostatectomy
BJU International
Jan 2013
A novel tool to assess the risk of urinary incontinence after nerve-sparing radical prostatectomy
What's known on the subject? and What does the study add? Urinary incontinence is one of the most important morbidities after radical prostatectomy that has detrimental effect on the postoperative quality of life. The present study provides an accurate and dynamic multivariable risk stratification tool that predicts..Cancer statistics, 2013
CA: A Cancer Journal for Clinicians
Jan 2013
Cancer statistics, 2013
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and..Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases
The Prostate
Jan 2013
Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases
Background: Approximately 90% of patients who die of Prostate Cancer (PCa) have bone metastases, which promote a spectrum of osteoblastic, osteolytic or mixed bone responses. Numerous secreted proteins have been reported to promote osteoblastic or osteolytic bone responses. We determined whether previously identified..Consumption of deep-fried foods and risk of prostate cancer
The Prostate
Jan 2013
Consumption of deep-fried foods and risk of prostate cancer
Background: Evidence suggests that high-heat cooking methods may increase the risk of prostate cancer (PCa). The addition of oil/fat, as in deep-frying, may be of particular concern, and has not specifically been investigated in relation to PCa. Potential mechanisms include the formation of potentially carcinogenic..Differing risk of cancer death among patients with lymph node metastasis after radical prostatectomy and pelvic lymph node dissection: identification of risk categories according to number of positive nodes and Gleason score
BJU International
Jan 2013
Differing risk of cancer death among patients with lymph node metastasis after radical prostatectomy and pelvic lymph node dissection: identification of risk categories according to number of positive nodes and Gleason score
What's known on the subject? and What does the study add? Lymph node (LN) status is one of the most important prognostic variables in patients undergoing radical prostatectomy, but not all patients with node-positive PCa are at the same risk of recurrence and cancer-specific death. In this study we evaluated the role..Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications
BJU International
Jan 2013
Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications
What's known on the subject? and What does the study add? Receipt of androgen deprivation therapy (ADT) has been associated with an increased risk of skeletal-associated complications, such as a decrease in bone mineral density and an increase in fracture risk. Many men with pre-existing health conditions receive ADT..High-grade prostate cancer and biochemical recurrence after radical prostatectomy among men using 5α-reductase inhibitors and alpha-blockers
The Prostate
Jan 2013
High-grade prostate cancer and biochemical recurrence after radical prostatectomy among men using 5α-reductase inhibitors and alpha-blockers
Background: Two clinical trials have shown that users of 5α-reductase inhibitors finasteride and dutasteride (5-ARIs) have reduced overall prostate cancer risk, while the proportion of high-grade tumors is increased. We studied tumor characteristics, risk of biochemical recurrence and mortality after radical..Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell
The Prostate
Jan 2013
Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell
Background: The role of CXCL1 in prostate cancer (PCa) progression has been poorly investigated. A limitation of previous studies is linked to the use of human PCa cell lines PC3 and DU145, producing CXCL8 at levels strongly exceeding CXCL1 levels. Moreover, in mouse models the sharing of CXCR2 receptor by both ligands..Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow
Bone
Jan 2013
Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow
Long bone is an anatomically complicated tissue with trabecular-rich metaphyses at two ends and cortical-rich diaphysis at the center. The traditional flushing method isolates only mesenchymal progenitor cells from the central region of long bones and these cells are distant from the bone surface. We propose that..Phase II open label, multi-center clinical trial of modulation of intermediate endpoint biomarkers by 1α-hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
The Prostate
Jan 2013
Phase II open label, multi-center clinical trial of modulation of intermediate endpoint biomarkers by 1α-hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin
Background: Prostate cancer is the most common malignancy and second leading cause of cancer related deaths in American men supporting the study of prostate cancer chemoprevention. Major risk factors for this disease have been associated with low serum levels of vitamin D. Here, we evaluate the biologic activity of a..Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review
Urology
Jan 2013
Phosphodiesterase-5 Expression and Function in the Lower Urinary Tract: A Critical Review
Both clinical and preclinical studies have mostly shown beneficial effects for Phosphodiesterase-5 (PDE-5) inhibitors in the treatment of lower urinary tract symptoms. Molecular studies have consistently shown abundant PDE-5 expression in bladder smooth muscle. Data concerning urethral PDE-5 expression have been..Place of Residence and Primary Treatment of Prostate Cancer: Examining Trends in Rural and Nonrural Areas in Wisconsin
Urology
Jan 2013
Place of Residence and Primary Treatment of Prostate Cancer: Examining Trends in Rural and Nonrural Areas in Wisconsin
Objective: To determine whether rural residents were at a disadvantage compared with urban residents with regard to the receipt of curative therapy for prostate cancer. Materials and Methods: Using the Breast and Prostate Cancer Data Quality and Patterns of Care Study II, patients with prostate cancer who were..Pooled Analysis of Phase II Trials Evaluating Weekly or Conventional Cisplatin as First-Line Therapy for Advanced Urothelial Carcinoma
Clinical Genitourinary Cancer
Jan 2013
Pooled Analysis of Phase II Trials Evaluating Weekly or Conventional Cisplatin as First-Line Therapy for Advanced Urothelial Carcinoma
Background: Weekly gemcitabine with GC every 3-4 weeks is considered conventional first-line chemotherapy for advanced urothelial carcinoma (UC). Weekly split-dose cisplatin with wGC might be less toxic and have similar activity, but has not been compared with GC. We pooled published phase II trials of GC and wGC to..Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non-metastatic carcinoma invading bladder muscle: results from a nationwide case–control study
BJU International
Jan 2013
Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non-metastatic carcinoma invading bladder muscle: results from a nationwide case–control study
What's known on the subject? and What does the study add? Positive surgical margin (PSM) frequency after radical cystectomy has been estimated to be 4–15%. Studies that have not distinguished between the different sites of PSM have failed to show that they are an independent prognostic factor for disease-free survival...Prevalence of ST131 Among Fluoroquinolone-resistant Escherichia coli Obtained From Rectal Swabs Before Transrectal Prostate Biopsy
Urology
Jan 2013
Prevalence of ST131 Among Fluoroquinolone-resistant Escherichia coli Obtained From Rectal Swabs Before Transrectal Prostate Biopsy
Objective: To identify the prevalence and characteristics of fluoroquinolone-resistant (FQ-R) Escherichia coli ST131 isolates in men undergoing ultrasound-guided transrectal prostate biopsy (TPB). Materials and Methods: Twenty-seven FQ-R E coli isolates from rectal swabs from 136 men undergoing TPB at 3 institutions in..Prognostic value of ERG oncoprotein in prostate cancer recurrence and cause-specific mortality
The Prostate
Jan 2013
Prognostic value of ERG oncoprotein in prostate cancer recurrence and cause-specific mortality
Background: ETS-related gene (ERG) protein is present in 40–70% of prostate cancer and is correlated with TMPRSS2-ERG gene rearrangements. This study evaluated ERG expression at radical prostatectomy to determine whether it was predictive of earlier relapse or prostate cancer-specific mortality (PCSM). Methods: One..Schwann cell-mediated delivery of glial cell line-derived neurotrophic factor restores erectile function after cavernous nerve injury
International Journal of Urology
Jan 2013
Schwann cell-mediated delivery of glial cell line-derived neurotrophic factor restores erectile function after cavernous nerve injury
Objectives: To evaluate the time-course of functional recovery after cavernous nerve injury using glial cell line-derived neurotrophic factor-transduced Schwann cell-seeded silicon tubes. Methods: Sections of the cavernous nerves were excised bilaterally (5 mm), followed by immediate bilateral surgical repair. A total..Shock Wave Lithotripsy of Vesical Stones in Patients With Infravesical Obstruction: An Underused Noninvasive Approach
Urology
Jan 2013
Shock Wave Lithotripsy of Vesical Stones in Patients With Infravesical Obstruction: An Underused Noninvasive Approach
Objective: To evaluate the effectiveness and safety of shock wave lithotripsy in the management vesical stones in patients with infravesical obstruction. Materials and Methods: From March 2007 to April 2010, 59 male patients with infravesical obstruction were treated using the Dornier Compact Delta II Lithotriptor for..The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
The Prostate
Jan 2013
The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland
Background: The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20-fold). The geographical and ethnic extent of this recurrent allele has not yet been determined. Methods: We assayed for the presence of the G84E mutation in 3,515 prostate cancer..The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score
Urology
Jan 2013
The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score
Objective: To investigate the total prostate-specific antigen (tPSA), free PSA (fPSA), and free/total PSA (fPSA/tPSA) ratio in patients with liver cirrhosis (LC) according to the severity of hepatic insufficiency. Methods: Eighty-two male patients with LC were studied. The severity of liver disease was categorized by..Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model
The Prostate
Jan 2013
Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model
Background: Bone metastasis is a serious problem for individuals with prostate cancer, and the effects of the anticancer drug docetaxel (DTX) are insufficient. We therefore examined the therapeutic potential of magnetic cationic liposomes (MCL) in a novel rat model that allows the evaluation of tumor immunity. The..Transurethral Laser Surgery for Benign Prostate Hyperplasia in Octogenarians: Safety and Outcomes
Urology
Jan 2013
Transurethral Laser Surgery for Benign Prostate Hyperplasia in Octogenarians: Safety and Outcomes
Objective: To evaluate the morbidity and perioperative outcome of different laser prostate techniques among octogenarians. Methods: We performed a retrospective review of our prospectively maintained laser prostate surgery database between 1998 and 2012. We identified 264 octogenarians (16.5%) who underwent laser..Spindle cell rhabdomyosarcoma of the prostate
International Journal of Urology
Jan 2013
Spindle cell rhabdomyosarcoma of the prostate
The spindle cell rhabdomyosarcoma is a rare variant of the embryonal rhabdomyosarcoma, mostly occurring in childhood. Only a few cases are described in adults. To date, no case of the spindle cell subtype of the prostatic embryonal rhabdomyosarcoma has been published. We report on a 23-year-old man, initially..Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population
BJU International
Jan 2013
Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population
What's known on the subject? and What does the study add? The use of a single, elevated PSA level to screen for prostate cancer is controversial given its reported low specificity and the questionable benefits of PSA screening on prostate cancer mortality. Current guidelines in the USA recommend against screening using..Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort
BJU International
Jan 2013
Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort
What's known on the subject? and What does the study add? Family history (FH) is a major risk factor for the development of prostate cancer. The search for genetic variants has led to genome-wide association studies (GWAS), which have so far reported 47 susceptibility loci that predispose men to prostate cancer...Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer
BJU International
Jan 2013
Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer
What's known on the subject? and What does the study add? The use of MRI for prostate cancer diagnosis and staging is increasing. Indications for prostate MRI are not defined and many clinicians are unsure of how best to use MRI to aid clinical decisions. This evidence-based medicine article addresses the clinical..Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer?
BJU International
Jan 2013
Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer?
What's known on the subject? and What does the study add? Urothelial carcinoma of the bladder (UCB) is more prevalent in men than women; however, in women the tumour stage is generally more advanced at the time of the diagnosis and the prognosis is worse. Possible explanations include anatomical, genetic and..Pathological and biochemical outcomes after radical prostatectomy in men with low-risk prostate cancer meeting the Prostate Cancer International: Active Surveillance criteria
BJU International
Jan 2013
Pathological and biochemical outcomes after radical prostatectomy in men with low-risk prostate cancer meeting the Prostate Cancer International: Active Surveillance criteria
What's known on the subject? and What does the study add? Active surveillance has been widely accepted as a treatment tool for low-risk prostate cancer, and use of the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria can select smaller and less aggressive tumours in low-risk disease. The..A contemporary update on rates and management of toxicities of targeted therapies for metastatic renal cell carcinoma
Cancer Treatment Reviews
Jan 2013
A contemporary update on rates and management of toxicities of targeted therapies for metastatic renal cell carcinoma
Background: To provide an updated review of adverse events associated with sunitinib, pazopanib, bevacizumab, temsirolimus, axitinib, everolimus and sorafenib and their management. Materials and methods: We performed a PubMed and Cochrane-based review of side effects associated with the seven agents including product..Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma
Cancer Letters
Jan 2013
Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma
Aldehyde dehydrogenase 1 (ALDH1) activity has now been employed successfully as a cancer stem cells (CSCs) marker in various tumors. We wanted to investigate whether ALDH1 can be used as a putative CSCs marker and a powerful prognostic factor in nasopharyngeal carcinoma (NPC). Here, we isolated ALDH1-positive cells..Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover
Cancer Letters
Jan 2013
Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover
Store-operated Ca2+ entry (SOCE) is a main Ca2+ influx pathway controlling the intracellular Ca2+ concentration in normal hepatocytes and hepatocellular carcinoma (HCC) cells. Ca2+ influx has been demonstrated to be involved in liver oncogenesis. Stromal interacting molecule (STIM) 1 acts as a sensor for the level of..Comparison of Dietary and Lifestyle Habits Among Stage III and Metastatic Colorectal Cancer Patients: Findings from CALGB 89803 and CALGB 80405
Clinical Colorectal Cancer
Jan 2013
Comparison of Dietary and Lifestyle Habits Among Stage III and Metastatic Colorectal Cancer Patients: Findings from CALGB 89803 and CALGB 80405
Background: Cancer patients often pursue lifestyle and dietary changes with the aim to improve outcomes. Using data from 2 large National Cancer Institute-sponsored clinical trials, we report on the dietary and lifestyle practices of patients receiving therapy for stage III colon or metastatic colorectal cancer...Development and validation of a new questionnaire measuring eating disordered behaviours post bariatric surgery
Clinical Obesity
Jan 2013
Development and validation of a new questionnaire measuring eating disordered behaviours post bariatric surgery
Contextualization of post-surgery circumstances in terms of key behaviours and emotions related to eating is crucial for reliable screening. Disordered eating post surgery is characterized by frequent snacking and a sense of loss of control over food intake. The purpose of this study was to evaluate the psychometric..Integrating user perspectives into the development of a web-based weight management intervention
Clinical Obesity
Jan 2013
Integrating user perspectives into the development of a web-based weight management intervention
The objective of this study was to adapt the design of our weight management intervention to the needs, expectations and capabilities of potential users. In study 1, we interviewed 25 people about their experiences of weight management. The findings of these interviews were combined with findings from existing theory..Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor
Clinical Genitourinary Cancer
Jan 2013
Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor
Background: Our objective was to perform a long-term evaluation of conservative surgical treatment of Leydig cell tumors. Patients and Methods: A multicenter retrospective clinical study was performed at 6 European centers. Case files of all patients diagnosed with Leydig cell tumor and treated with conservative..Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer
Cancer Letters
Jan 2013
Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer
We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was..Socio-demographic and obstetrical correlates of pre-pregnancy body mass index and gestational weight gain
Clinical Obesity
Jan 2013
Socio-demographic and obstetrical correlates of pre-pregnancy body mass index and gestational weight gain
Both pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are important determinants of a healthy pregnancy outcome and may show important variation. To study the influence of socio-demographic and obstetrical correlates on pre-pregnancy BMI and GWG, data of 54 022 singleton term pregnancies were..Targeting triple negative breast cancer: Is p53 the answer?
Cancer Treatment Reviews
Jan 2013
Targeting triple negative breast cancer: Is p53 the answer?
Triple negative breast cancers, which are defined by lack of expression of estrogen, progesterone, or HER2 receptors, represent approximately 15% of all breast cancers, although they account for a much higher proportional of breast cancer mortality. This is due both to their innate aggressive biological..The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
Cancer Letters
Jan 2013
The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in..Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis
Cancer Letters
Jan 2013
Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis
The anti-tumor activity, metronomic chemotherapy sensitization potential and metastatic effects of the endogenous angiogenesis inhibitors thrombospondin-1 and PEDF were investigated in KM12 colon adenocarcinoma xenografts. Thrombospondin-1 and PEDF decreased KM12 tumor microvessel density, increased macrophage..A guanidinylated bioreducible polymer as a novel gene carrier to the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction
Andrology
Jan 2013
A guanidinylated bioreducible polymer as a novel gene carrier to the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction
A prerequisite for the successful clinical application of gene therapy in erectile dysfunction (ED) is the availability of safe and efficient gene delivery systems. The aim of this study was to examine the effectiveness of guanidinylated bioreducible polymer (GBP) polyplexes for gene delivery systems, which take..Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse
Andrology
Jan 2013
Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse
The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8−/− mice lacking Sox9 in Sertoli cells fail to form testis cords and cannot establish spermatogenesis. Although genetic and histological data show an important..On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid
Andrology
Jan 2013
On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid
Oxidative stress is known to have a major impact on human sperm function and, as a result, there is a need to develop sensitive methods for measuring reactive oxygen species (ROS) generation by these cells. A variety of techniques have been developed for this purpose including chemiluminescence (luminol and lucigenin),..Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders
Andrology
Jan 2013
Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders
Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whether..Posthumous sperm utilization in men presenting for sperm banking: an analysis of patient choice
Andrology
Jan 2013
Posthumous sperm utilization in men presenting for sperm banking: an analysis of patient choice
The question remains as to whether or not men would agree to posthumous sperm use for pregnancy initiation. Often, these individuals' lives are suddenly interrupted and prior consent is rarely given. Therefore, post-mortem retrieval or use of these spermatozoa remains controversial and the incidence of consent for..Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples
Andrology
Jan 2013
Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples
Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and..Sexual intercourse with leucocytospermic men may be a possible booster of oxidative stress in female partners of infertile couples
Andrology
Jan 2013
Sexual intercourse with leucocytospermic men may be a possible booster of oxidative stress in female partners of infertile couples
Human semen has undoubtedly significant influence on the organism of the female counterpart. At the same time there are no studies in English literature investigating the influence of sexual intercourse on oxidative stress level in women's organism. Seventeen infertile couples where male partners were with (n = 5) or..Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells
Clinical Colorectal Cancer
Jan 2013
Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells
Background: Colorectal cancer is the second leading cause of cancer-related mortality and frequently presents with locally advanced or metastatic disease. Adenovirus (Ad) vectors are important gene delivery agents because they offer efficient and broad tissue transduceability. However, their ability to penetrate..Air pollution and multiple acute respiratory outcomes
European Respiratory Journal
Jan 2013
Air pollution and multiple acute respiratory outcomes
Short-term effects of air pollutants on respiratory mortality and morbidity have been consistently reported but usually studied separately. To more completely assess air pollution effects, we studied hospitalisations for respiratory diseases together with out-of hospital respiratory deaths. A “time-stratified”..Climate change, extreme weather events, air pollution and respiratory health in Europe
European Respiratory Journal
Jan 2013
Climate change, extreme weather events, air pollution and respiratory health in Europe
Due to climate change, air pollution patterns are changing in several urbanized areas of the world, with a significant effect on respiratory health both independently and synergistically with weather conditions; climate scenarios show Europe as one of the most vulnerable regions. European studies on heat wave episodes..Fine and coarse particulate air pollution in relation to respiratory health in Sweden
European Respiratory Journal
Jan 2013
Fine and coarse particulate air pollution in relation to respiratory health in Sweden
Health effects have repeatedly been associated with residential levels of air pollution. However, it is difficult to disentangle effects of long-term exposure to locally generated and long-range transported pollutants as well as of exhaust emissions and wear particles from road traffic. We aimed to investigate effects..Fixed dose combination anti-tuberculosis therapy: a systematic review and meta-analysis
European Respiratory Journal
Jan 2013
Fixed dose combination anti-tuberculosis therapy: a systematic review and meta-analysis
Fixed-dose combination (FDC) formulations are currently recommended for treatment of active tuberculosis. We have conducted a systematic review to evaluate the risk of treatment failure or disease relapse, acquired drug resistance, bacterial conversion after two months of treatment, adverse events, adherence, and..High variability in results of semen analysis in Andrology Laboratories in Tuscany (Italy): the experience of an external quality control (EQC) programme
Andrology
Jan 2013
High variability in results of semen analysis in Andrology Laboratories in Tuscany (Italy): the experience of an external quality control (EQC) programme
We report the results of the first three trials of an external quality control (EQC) programme performed in 71 laboratories executing semen analysis in Tuscany Region (Italy). At the end of the second trial, participants were invited to attend a teaching course illustrating and inviting to adhere to procedures..Impact of bronchiectasis and trapped air on quality of life and exacerbations in CF
European Respiratory Journal
Jan 2013
Impact of bronchiectasis and trapped air on quality of life and exacerbations in CF
Cystic fibrosis (CF) is primarily characterized by bronchiectasis and trapped air on chest computed tomography (CT). The Cystic Fibrosis Questionnaire-Revised Respiratory Symptoms scale (CFQ-R RSS) measures health-related quality of life. To validate bronchiectasis, trapped air and CFQ-R RSS as outcome measures, we..Overexpressed PC1/3 induces an epithelial-mesenchymal transition in airway epithelium
European Respiratory Journal
Jan 2013
Overexpressed PC1/3 induces an epithelial-mesenchymal transition in airway epithelium
The proprotein convertases are serine proteases responsible for the proteolytic maturation of many precursor proteins involved in upper airway remodeling during nasal polyposis. We have previously found that proprotein convertase PC1/3 is expressed in human nasal mucosa. However, whether PC1/3 is related to nasal..Sperm counts may have declined in young university students in Southern Spain
Andrology
Jan 2013
Sperm counts may have declined in young university students in Southern Spain
Several studies have investigated temporal trends in semen quality in Northern Europe, but none has examined this question in Southern Europe. A prior study conducted in Almeria Province (Southern Spain) reported higher sperm count and concentration among Spanish young men recruited from 2001 to 2002 compared with..Thenar oxygen saturation (StO2) during weaning from mechanical ventilation: an observational study
European Respiratory Journal
Jan 2013
Thenar oxygen saturation (StO2) during weaning from mechanical ventilation: an observational study
To determine whether thenar tissue oxygen saturation (StO2) measured by non-invasive near-infrared spectroscopy, and its changes derived from an ischemic challenge, are associated to weaning outcome. Prospective observational study in a 26-bed medical-surgical intensive care unit. Patients receiving mechanical..TLR-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells
European Respiratory Journal
Jan 2013
TLR-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells
Haemorrhage-induced immunosuppression has been linked to nosocomial infections. We assessed the impact of MonoPhosphoryl Lipid A (MPLA), a TIR-domain-containing adaptor protein inducing Interferon-biased Toll Like Receptor 4 agonist currently used as a vaccine adjuvant in humans, on post-haemorrhage susceptibility to..Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: asthma versus controls
European Respiratory Journal
Jan 2013
Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: asthma versus controls
The cellular and molecular pathways in asthma are highly complex. Increased understanding can be obtained by unbiased transcriptomic analysis (RNA-Seq). We hypothesized that the transcriptomic profile of whole human endobronchial biopsies differs between asthma patients and controls. First, we investigated the..Extended release methylphenidate for treatment of amphetamine/methamphetamine dependence: a randomised, double-blind, placebo controlled trial
Addiction
Jan 2013
Extended release methylphenidate for treatment of amphetamine/methamphetamine dependence: a randomised, double-blind, placebo controlled trial
Aims: To assess the efficacy of methylphenidate as a substitution therapy for amphetamine/methamphetamine dependence in Finland and New Zealand. Design: parallel group, double-blind, randomised placebo controlled trial. Setting: outpatient care. Participants: amphetamine/methamphetamine dependent, aged 16-65...In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma
Prenatal Diagnosis
Jan 2013
In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma
Objectives: We aimed to demonstrate local thrombin generation by fetal membranes, as well as its ability to generate fibrin from fibrinogen concentrate. Furthermore, we aimed to investigate the efficacy of collagen plugs, soaked with plasma and fibrinogen, to seal iatrogenic fetal membrane defects. Methods: Thrombin..A case report of an incidental finding of a 46,XX, SRY-negative male with masculine phenotype during standard fertility workup with review of the literature and proposed immediate and long-term management guidance
Fertility and Sterility
Jan 2013
A case report of an incidental finding of a 46,XX, SRY-negative male with masculine phenotype during standard fertility workup with review of the literature and proposed immediate and long-term management guidance
Objective: To describe and explore the current literature on the rare genetic condition of 46,XX SRY-negative males. In addition, we propose comprehensive clinical guidelines in the management of this condition to aid fertility clinicians in their management of affected individuals. Design: Case report with expert..A rare tumor of the lung: Pulmonary sclerosing hemangioma (pneumocytoma)
Respiratory Medicine
Jan 2013
A rare tumor of the lung: Pulmonary sclerosing hemangioma (pneumocytoma)
A 67-year-old woman was referred to our department for further evaluation of her abnormal, chest radiogram. Thorax computed tomography revealed a well-circumscribed, round mass in the middle lobe of the right lung. A thoracotomy was performed and pulmonary sclerosing hemangioma was diagnosed. We herein present a rare..Abdominal adiposity and family income-to-poverty ratio in American women
Obesity Research & Clinical Practice
Jan 2013
Abdominal adiposity and family income-to-poverty ratio in American women
Objective: We examined (a) secular changes in abdominal fat accumulation (AFA) and family income-to-poverty ratio (PIR) across race/ethnicity, education and age in Mexican (MA), non-Hispanic Whites (NHW), non-Hispanic Black (NHB), and (b) association between PIR and AFA among American women. Methods: Data (n=9787) from..Are sperm DNA fragmentation, hyperactivation, and hyaluronan-binding ability predictive for fertilization and embryo development in in vitro fertilization and intracytoplasmic sperm injection?
Fertility and Sterility
Jan 2013
Are sperm DNA fragmentation, hyperactivation, and hyaluronan-binding ability predictive for fertilization and embryo development in in vitro fertilization and intracytoplasmic sperm injection?
Objective: To determine the diagnostic value of the following sperm function tests in predicting the fertilizing ability of spermatozoa in conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI): hyaluronan-binding assay (HBA), DNA fragmentation (Halosperm), and hyperactivity. Design:..Biomarkers for ectopic pregnancy and pregnancy of unknown location
Fertility and Sterility
Jan 2013
Biomarkers for ectopic pregnancy and pregnancy of unknown location
Early pregnancy failure is the most common complication of pregnancy, and 1% to 2% of all pregnancies will be ectopic. As one of the leading causes of maternal morbidity and mortality, diagnosing ectopic pregnancy and determining the fate of a pregnancy of unknown location are of great clinical concern. Several serum..Consecutive GnRH-antagonist IVF cycles: does the elapsed time interval between successive treatments affect outcomes?
Fertility and Sterility
Jan 2013
Consecutive GnRH-antagonist IVF cycles: does the elapsed time interval between successive treatments affect outcomes?
Objective: To determine whether patients who failed an IVF cycle can proceed with a subsequent IVF cycle after waiting only one menstrual cycle, or whether there is a benefit to allowing two or more menstrual cycles to elapse before proceeding. Design: Retrospective cohort study. Setting: Academic medical center...Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation
Fertility and Sterility
Jan 2013
Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation
Objective: To investigate the effects of cryoprotectants on the expression of AQP7 in oocytes. Design: Experimental animal study. Setting: University-based research laboratory. Animal(s): Adult female C57BL/6J mice. Intervention(s): In metaphase II (MII) oocytes obtained from adult female C57BL/6J mice and from..Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo-oxygenase inhibitor naïve population
Acta Paediatrica
Jan 2013
Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo-oxygenase inhibitor naïve population
Aims: To examine the relationship between early duct diameter and patent ductus arteriosus (PDA) symptoms. Methods: A retrospective study of infants <29 weeks of gestation with early colour Doppler assessment of PDA diameter, in whom PDA was managed conservatively, without cyclo-oxygenase inhibitor (COI) treatment...Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma
Respiratory Medicine
Jan 2013
Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma
Objective: To compare the efficacy of theophylline plus salmeterol/fluticasone propionate combination product (SFC) with SFC plus placebo in asthmatic patients. Methods: In this randomized, stratified, parallel-group study, 325 patients were randomized to receive either 200 mg theophylline plus 50/250 μg SFC or placebo..Expression of the pluripotent transcription factor OCT4 promotes cell migration in endometriosis
Fertility and Sterility
Jan 2013
Expression of the pluripotent transcription factor OCT4 promotes cell migration in endometriosis
Objective: To identify the impact of the pluripotent transcription factor OCT4 in endometrial cell migration and endometriosis. Design: The OCT4 expression and cell migration study. Setting: Research institution and reproductive medical clinic. Patient(s): Nine subjects with normal endometrium, 3 subjects with normal..Have the boundaries of the ‘grey zone’ of perinatal resuscitation changed for extremely preterm infants over 20 years?
Acta Paediatrica
Jan 2013
Have the boundaries of the ‘grey zone’ of perinatal resuscitation changed for extremely preterm infants over 20 years?
Aim: To determine the boundaries of the grey zone of discretionary resuscitation over the past 20 years. Background: As the likelihood of survival improves over time, the BW- and GA-specific boundaries of discretionary nonresuscitation should fall. Hypothesis: Between 1988 and 2008 reductions in BW- and GA-specific..Impact of nursing care on temperature environment in preterm newborns nursed in closed convective incubators
Acta Paediatrica
Jan 2013
Impact of nursing care on temperature environment in preterm newborns nursed in closed convective incubators
Aims: Very-low-birth-weight (VLBW) neonates require regular nursing procedures with frequent opening of the incubator resulting in a decrease in incubator air temperature. This study was designed to assess changes in the thermal status of VLBW neonates according to the type of nursing care and incubator openings...Inhaler devices – From theory to practice
Respiratory Medicine
Jan 2013
Inhaler devices – From theory to practice
This brief overview of the factors determining lung deposition of aerosols provides background information required by health care providers when instructing patients to use their prescribed inhalers. We discuss differences in the optimal inhalation manoeuvres for each type of aerosol generator and the difficulties..Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach
Fertility and Sterility
Jan 2013
Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach
Objective: To estimate the prevalence of infertility using a current duration approach for comparison with a traditional constructed measure. Design: Cross-sectional survey. Setting: Not applicable. Patient(s): A nationally representative sample of females aged 15–44 years. Intervention(s): None. Main Outcome..Prospective antibody case finding of coeliac disease in type-1 diabetes children: need of biopsy revisited
Acta Paediatrica
Jan 2013
Prospective antibody case finding of coeliac disease in type-1 diabetes children: need of biopsy revisited
Aim: To evaluate whether coeliac disease (CD) can be diagnosed by measuring autoantibodies without small-intestinal mucosal biopsies in children with type 1 diabetes. Methods: Case finding of CD was undertaken in 181 consecutive IgA-competent children with type 1 diabetes using transglutaminase 2 (TG2) and endomysial..The effect of hereditary versus acquired thrombophilia on triple test Down's syndrome screening
Prenatal Diagnosis
Jan 2013
The effect of hereditary versus acquired thrombophilia on triple test Down's syndrome screening
Objective: To compare the profile of mid gestation triple test serum markers between a cohort of women with history of pregnancy complications with hereditary versus acquired thrombophilia. All were treated with low molecular weight heparin (LMWH) prior to 12 weeks' gestation. Methods: A retrospective analysis of..The pattern and time course of somatosensory changes in the human UVB sunburn model reveal the presence of peripheral and central sensitization
Pain
Jan 2013
The pattern and time course of somatosensory changes in the human UVB sunburn model reveal the presence of peripheral and central sensitization
The UVB sunburn model was characterized with a comprehensive battery of quantitative sensory testing (QST). Primary hyperalgesia in UVB-irradiated skin and secondary hyperalgesia in adjacent, non-irradiated skin were studied in 22 healthy subjects 24 h after irradiation with UVB at 3–fold minimal erythema dosis of a..The role of circulating sex hormones in menstrual cycle dependent modulation of pain-related brain activation
Pain
Jan 2013
The role of circulating sex hormones in menstrual cycle dependent modulation of pain-related brain activation
Sex differences in pain sensitivity have been consistently found but the basis for these differences is incompletely understood. The present study assessed how pain-related neural processing varies across the menstrual cycle in normally cycling, healthy females, and whether menstrual cycle effects are based on..High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults
Clinical Nutrition
Jan 2013
High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults
Background & aims: Iron overload is known to cause diabetes. However, the underlying mechanism is poorly understood. We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that..Increased autophagy in the placental territory of selective intrauterine growth-restricted monochorionic twins
Prenatal Diagnosis
Jan 2013
Increased autophagy in the placental territory of selective intrauterine growth-restricted monochorionic twins
Subject: This study investigates the placental autophagic activity in growth-restricted fetuses in the monochorionic (MC) twin model. Patients and methods: Forty MC twins were prospectively enrolled in this study, including 21 with and 19 without selective intrauterine growth restriction (sIUGR), defined as birth..A Case of Necrotizing Fasciitis with a LRINEC Score of Zero: Clinical Suspicion Should Trump Scoring Systems
Journal of Emergency Medicine
Jan 2013
A Case of Necrotizing Fasciitis with a LRINEC Score of Zero: Clinical Suspicion Should Trump Scoring Systems
Background: Necrotizing fasciitis (NF) is a potentially lethal infection involving the skin, subcutaneous tissue, and fascia. The Laboratory Risk Indicator for Necrotizing fasciitis (LRINEC) score has been proposed as a way of using abnormal laboratory values to distinguish between severe cellulitis and necrotizing..Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies
Respiratory Medicine
Jan 2013
Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies
Background: The role of lung function monitoring in subjects identified as having asymptomatic alpha-1 antitrypsin deficiency (AATD) is uncertain. We investigated for the first time the age these tests start to deviate from results expected in a healthy population with particular reference to the group with the best..Cascade testing in families of carriers identified through newborn screening in Western Brittany (France)
Journal of Cystic Fibrosis
Jan 2013
Cascade testing in families of carriers identified through newborn screening in Western Brittany (France)
Background: Newborn screening (NBS) for cystic fibrosis (CF) can lead to the detection of healthy carriers. We report a unique assessment of family testing following the identification of carriers by NBS for over 20years, in an area where CF is frequent. Methods: We reviewed all of the carriers identified by NBS..Changing thresholds and incidence of antibiotic treatment of cystic fibrosis pulmonary exacerbations, 1995–2005
Journal of Cystic Fibrosis
Jan 2013
Changing thresholds and incidence of antibiotic treatment of cystic fibrosis pulmonary exacerbations, 1995–2005
Background: Increased chronic therapy use and improved cystic fibrosis (CF) patient health should be accompanied by reduced pulmonary exacerbation-associated antibiotic treatment incidence. Methods: Treatment incidence rates and associated sign/symptom scores from 1995–2005 were studied in Epidemiologic Study of CF..Chronic Migraine and Chronic Tension-Type Headache Are Associated With Concomitant Low Back Pain: Results of the German Headache Consortium (GHC) Study
Pain
Jan 2013
Chronic Migraine and Chronic Tension-Type Headache Are Associated With Concomitant Low Back Pain: Results of the German Headache Consortium (GHC) Study
Objective: Evaluate the association between low and frequent low back pain and chronic migraine (CM) and chronic tension-type headache (CTTH) in a large, German population-based sample. Methods: Headaches diagnosed according ICHD-2 criteria and categorized according to frequency (episodic 1-14 days/month or chronic 15..Cognitive Behavioral Therapy, Self-Efficacy, and Depression in Persons with Chronic Pain
Pain Management Nursing
Jan 2013
Cognitive Behavioral Therapy, Self-Efficacy, and Depression in Persons with Chronic Pain
Chronic pain is a complex and often disabling condition compounded by depression and poor self-efficacy. The purpose of this evidence-based project was to explore the relationship of cognitive behavioral therapy (CBT)–focused groups with self-efficacy and depression in persons with chronic pain at an intensive..Development and validation of a cystic fibrosis genetic knowledge questionnaire within the general population of the United States
Journal of Cystic Fibrosis
Jan 2013
Development and validation of a cystic fibrosis genetic knowledge questionnaire within the general population of the United States
Background: There is no valid and reliable instrument to evaluate genetic education and counseling received by parents who have an infant with a positive newborn screen for cystic fibrosis (CF). Methods: This study assessed the validity and reliability of a new instrument designed to evaluate the effectiveness of..Distribution of CFTR mutations in the Czech population: Positive impact of integrated clinical and laboratory expertise, detection of novel/de novo alleles and relevance for related/derived populations
Journal of Cystic Fibrosis
Jan 2013
Distribution of CFTR mutations in the Czech population: Positive impact of integrated clinical and laboratory expertise, detection of novel/de novo alleles and relevance for related/derived populations
Background: This two decade long study presents a comprehensive overview of the CFTR mutation distribution in a representative cohort of 600 Czech CF patients derived from all regions of the Czech Republic. Methods: We examined the most common CF-causing mutations using the Elucigene CF-EU2v1™ assay, followed by MLPA,..High dietary fiber intake prevents stroke at a population level
Clinical Nutrition
Jan 2013
High dietary fiber intake prevents stroke at a population level
Background & aims: This research was aimed at clarifying whether high dietary fiber intake has an impact on incidence and risk of stroke at a population level. Methods: In 1647 unselected subjects, dietary fiber intake (DFI) was detected in a 12-year population-based study, using other dietary variables, anagraphics,..Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: A meta-analysis of randomized controlled trials
Clinical Nutrition
Jan 2013
Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: A meta-analysis of randomized controlled trials
Background & aims: The efficacy of homocysteine-lowering therapy with folic acid to lower homocysteine levels in an effort to reduce cardiovascular disease (CVD) risk in patients with kidney disease remains inconclusive. We conducted a meta-analysis of relevant randomized trials to further examine this issue. Methods:..Is the Pain Reducing Effects of Opioid Medication Reliable? A Psychophysical Study of Morphine and Pentazocine Analgesia
Pain
Jan 2013
Is the Pain Reducing Effects of Opioid Medication Reliable? A Psychophysical Study of Morphine and Pentazocine Analgesia
A number of laboratory studies have confirmed the efficacy of opioid medication in reducing pain generated by a number of psychophysical modalities. However, one implicit assumption of clinical and experimental pain testing of analgesics is that the analgesic response is stable and will be comparable across repeated..Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis
Journal of Cystic Fibrosis
Jan 2013
Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis
Background: Although there have been case reports of hypothalamic–pituitary–adrenal (HPA) axis suppression in patients with cystic fibrosis (CF) caused by the combination of oral itraconazole and inhaled fluticasone, to date no study has assessed the incidence of this potentially serious side effect. Methods: Synacthen..Jordanian Patients' Satisfaction with Pain Management
Pain Management Nursing
Jan 2013
Jordanian Patients' Satisfaction with Pain Management
Pain is still undertreated among hospitalized patients. Recently, patient satisfaction with pain management has received significant attention. This field has not yet been explored among Jordanian patients. The purpose of this study was to determine the knowledge regarding pain characteristics, beliefs, and..Large duplication in MTM1 associated with myotubular myopathy
Neuromuscular Disorders
Jan 2013
Large duplication in MTM1 associated with myotubular myopathy
Myotubular myopathy is a subtype of centronuclear myopathy with X-linked inheritance and distinctive clinical and pathologic features. Most boys with myotubular myopathy have MTM1 mutations. In remaining individuals, it is not clear if disease is due to an undetected alteration in MTM1 or mutation of another gene. We..Local Versus Epidural Anesthesia in Fast-Track Abdominal Aortic Surgery
Journal of Cardiothoracic and Vascular Anesthesia
Jan 2013
Local Versus Epidural Anesthesia in Fast-Track Abdominal Aortic Surgery
Objective: The aim of this study was to investigate a possible alternative to epidural anesthesia/analgesia. The authors compared thoracic epidural anesthesia/analgesia with continuous wound infiltration anesthesia/analgesia in patients scheduled for mini-invasive abdominal aortic surgery in a fast-track setting...Pertussis and Persistent Cough: Practical, Clinical and Epidemiologic Issues
Journal of Emergency Medicine
Jan 2013
Pertussis and Persistent Cough: Practical, Clinical and Epidemiologic Issues
Background: Epidemiologic issues of testing, treatment, prevention, immunization, mandated reporting, and post-exposure prophylaxis do not often intrude on the Emergency Department management of the well-appearing adolescent or adult with a couple of weeks of cough. Objectives: Considering that waning immunity to..Randomised placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors
Clinical Nutrition
Jan 2013
Randomised placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors
Background & aims: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health. Design: Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 1.7 mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1)..The assessment of inspiratory muscle fatigue in healthy individuals: A systematic review
Respiratory Medicine
Jan 2013
The assessment of inspiratory muscle fatigue in healthy individuals: A systematic review
Inspiratory muscle fatigue (IMF) may contribute to the development of exercise limitation and respiratory failure. Identifying fatigue of the inspiratory muscles requires a rigorous and integrative methodological approach. However, there is no consensus about an optimal protocol to induce and assess the fatigability of..The Effect of a Program to Promote Play to Reduce Children's Post-Surgical Pain: With Plush Toys, It Hurts Less
Pain Management Nursing
Jan 2013
The Effect of a Program to Promote Play to Reduce Children's Post-Surgical Pain: With Plush Toys, It Hurts Less
Various nonpharmacological strategies to relieve hospitalized children's pain propose play as a central element. Play is considered an essential resource to improve the negative psychosocial effects of the disease and the hospitalization itself. However, the empirical research of play in health settings has not..The Predictive Value of Attentional Bias Towards Pain-Related Information in Chronic Pain Patients: A Diary Study
Pain
Jan 2013
The Predictive Value of Attentional Bias Towards Pain-Related Information in Chronic Pain Patients: A Diary Study
Theoretical accounts of chronic pain hypothesize that attentional bias towards pain-related information is a maintaining or exacerbating factor, fuelling further pain, disability and distress. However, empirical research testing this idea is currently lacking. In the present study, we investigated whether attentional..The Rasch-built Pompe-specific Activity (R-PAct) scale
Neuromuscular Disorders
Jan 2013
The Rasch-built Pompe-specific Activity (R-PAct) scale
We constructed a patient-based interval scale using Rasch analysis, specifically suited to quantify the effects of Pompe disease on patient’s ability to carry out daily life activities and their social participation: Rasch-built Pompe-specific Activity scale. Between July 2005 and April 2011, 186 patients aged 16 or..β-Blockers and Volatile Anesthetics May Attenuate Cardioprotection by Remote Preconditioning in Adult Cardiac Surgery: A Meta-analysis of 15 Randomized Trials
Journal of Cardiothoracic and Vascular Anesthesia
Jan 2013
β-Blockers and Volatile Anesthetics May Attenuate Cardioprotection by Remote Preconditioning in Adult Cardiac Surgery: A Meta-analysis of 15 Randomized Trials
Objective: Clinical trials on cardioprotection by remote ischemic preconditioning (RIPC) for adult patients undergoing cardiac surgery revealed mixed results. Previous meta-analyses have been conducted and found marked heterogeneity among studies. The aim of this meta-analysis was to evaluate the factors affecting..Congenital cataract screening in maternity wards is effective: evaluation of the Paediatric Cataract Register of Sweden
Acta Paediatrica
Dec 2012
Congenital cataract screening in maternity wards is effective: evaluation of the Paediatric Cataract Register of Sweden
Aim: To study which eye-screening protocol prevails in Swedish maternity/neonatal wards, evaluate efficacy in a prospective study and compare results with earlier Swedish retrospective results. Methods: Surveys were sent in 2006 to maternity/neonatal and women's health departments regarding screening policy. Response..A Pilot Study of Prasugrel Followed by Post-Procedural Maintenance with Clopidogrel in Patients Receiving Percutaneous Coronary Intervention
Journal of Interventional Cardiology
Dec 2012
A Pilot Study of Prasugrel Followed by Post-Procedural Maintenance with Clopidogrel in Patients Receiving Percutaneous Coronary Intervention
Background: Dual anti-platelet therapy including clopidogrel or prasugrel is standard of care for patients receiving stents. Prasugrel has quicker onset so it can be loaded later than clopidogrel with greater efficacy. However, prasugrel is much more expensive than clopidogrel. Objectives: To describe the incidence of..Aortic Valve Stenosis: To the Gradient and Beyond—The Mismatch Between Area and Gradient Severity
Journal of Interventional Cardiology
Dec 2012
Aortic Valve Stenosis: To the Gradient and Beyond—The Mismatch Between Area and Gradient Severity
The clinical severity of aortic stenosis (AS) is based largely on symptoms. However, AS severity is primarily determined by estimating the aortic valve area (AVA) and pressure gradients (ΔP). Conditions may arise in which there is a mismatch in severity between AVA and ΔP determinations secondary to errors in..Frequency of Coronary Angiography and Revascularization among Men and Women with Myocardial Infarction and Their Relationship to Mortality at One Year: An Analysis of the Geisinger Myocardial Infarction Cohort
Journal of Interventional Cardiology
Dec 2012
Frequency of Coronary Angiography and Revascularization among Men and Women with Myocardial Infarction and Their Relationship to Mortality at One Year: An Analysis of the Geisinger Myocardial Infarction Cohort
Objectives: To determine sex bias in the selection of strategies to evaluate patients with acute myocardial infarction (AMI), and determine if the choice of strategy influences survival. Background: Controversy exists regarding the role of female sex in the use of invasive evaluation for AMI and its possible effect on..25-hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18,791 participants
Journal of Thrombosis and Haemostasis
Dec 2012
25-hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18,791 participants
Background: Vitamin D has potential antithrombotic effects suggesting that vitamin D analogs could be used as adjunctive antithrombotic agents. However, epidemiological evidence of an association between reduced 25-hydroxyvitamin D concentrations and risk of venous thromboembolism is lacking. Objectives: We tested the..Fatty liver is a good indicator of subclinical atherosclerosis risk in obese children and adolescents regardless of liver enzyme elevation
Acta Paediatrica
Dec 2012
Fatty liver is a good indicator of subclinical atherosclerosis risk in obese children and adolescents regardless of liver enzyme elevation
Aim: To investigate the presence of association between nonalcoholic fatty liver disease (NAFLD) and subclinical atherosclerosis using carotid intima media thickness (c-IMT) in obese children and adolescents. Additionally, we wished to investigate the relationship between fatty liver and elevated liver enzymes...Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study
Acta Paediatrica
Dec 2012
Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study
Aim: Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD). Methods: Any child <15 years hospitalized with an HD diagnosis of BJI, alone or in combination with sepsis or..Platelet dysfunction associated with the novel Trp29Cys thromboxane A2 receptor variant
Journal of Thrombosis and Haemostasis
Dec 2012
Platelet dysfunction associated with the novel Trp29Cys thromboxane A2 receptor variant
Background: Genetic variations that affect the structure of the thromboxane A2 (TP) receptor provide insights into the function of this key platelet and vascular receptor, but are very rare in unselected populations. Objectives: To determine the functional consequences of the TP receptor Trp29Cys (W29C) substitution...Shared physical custody after family split-up: implications for health and well-being in Swedish schoolchildren
Acta Paediatrica
Dec 2012
Shared physical custody after family split-up: implications for health and well-being in Swedish schoolchildren
Aim: In Sweden, shared physical custody following a parental separation has emerged as means for children to keep close relationships with both parents. Previous studies show that children benefit from regular contact with both parents, who share responsibility for their social, emotional and economic welfare. In this..A PRC2 Dependent Repressive role of PRDM14 in Human Embryonic Stem Cells and iPSC Reprogramming
Stem Cells
Dec 2012
A PRC2 Dependent Repressive role of PRDM14 in Human Embryonic Stem Cells and iPSC Reprogramming
PRDM14 is an important determinant of the human embryonic stem cell (ESC) identity and works in concert with the core ESC regulators to activate pluripotency associated genes. PRDM14 has been previously reported to exhibit repressive activity in mouse ESCs and primordial germ cells (PGC); and while PRDM14 has been..Circulating citrullinated vimentin fragments reflect disease burden in Ankylosing Spondylitis and has prognostic capacity for radiographic progression
Arthritis & Rheumatism
Dec 2012
Circulating citrullinated vimentin fragments reflect disease burden in Ankylosing Spondylitis and has prognostic capacity for radiographic progression
Objective: Ankylosing spondylitis (AS) is considered a seronegative disease indicated by absent or low levels of antibodies against citrullinated proteins. We evaluated whether a citrullinated and MMP degraded fragment of vimentin (VICM) could be a prognostic biomarker in AS. Methods: Serum VICM was measured in samples..Merkel cell carcinoma with divergent differentiation: histopathological and immunohistochemical study of 15 cases with pcr analysis for merkel cell polyomavirus
Histopathology
Dec 2012
Merkel cell carcinoma with divergent differentiation: histopathological and immunohistochemical study of 15 cases with pcr analysis for merkel cell polyomavirus
Aims: We report 15 cases of Merkel cell carcinoma (MCC) with divergent differentiation to characterise its clinico-pathological spectrum and its relationship with the Merkel cell Polyomavirus (MCV). Methods and Results: Fifteen patients with a mean age of 81 were included. Follow-up was available in 13 cases (range 12..Neutrophil cannibalismtriggers TGF-β1 production andself-regulation of neutrophil inflammatory function in MSU crystal-induced inflammation
Arthritis & Rheumatism
Dec 2012
Neutrophil cannibalismtriggers TGF-β1 production andself-regulation of neutrophil inflammatory function in MSU crystal-induced inflammation
Objectives: To identify macrophage-independent sources of transforming growth factor-β1 (TGF-β1) production during monosodium urate monohydrate (MSU) crystal-induced inflammation and determine how TGF-β1 alters MSU crystal-recruited neutrophil functions. Methods: C57BL/6J mice were injected intraperitoneally with MSU..p53 controls autoimmune arthritis via the STAT3/STAT5-mediated regulation of the Th17–Treg balance
Arthritis & Rheumatism
Dec 2012
p53 controls autoimmune arthritis via the STAT3/STAT5-mediated regulation of the Th17–Treg balance
Objective: To investigate the connection between p53 and interleukin (IL)-17–producing helper T (Th17)/regulatory T (Treg) balance in rheumatoid arthritis (RA). Methods: Th17 and Treg cell frequencies were analyzed by flow cytometry and cytokine levels in the supernatant were determined using enzyme-linked..Self-perceived health status and mental health outcomes in young adults born with less than 1000 g
Acta Paediatrica
Dec 2012
Self-perceived health status and mental health outcomes in young adults born with less than 1000 g
Aim: To assess self-perceived health status and mental health outcomes of former extremely low-birth-weight (ELBW) infants at young adulthood compared with community norms and to analyse predictors of poor outcome. Methods: Fifty-five ELBW adults, 18 men (33%), with median (range) gestational age of 28.7 (25.0–34.0)..The fibromyalgia family study: A genome-scan linkage study
Arthritis & Rheumatism
Dec 2012
The fibromyalgia family study: A genome-scan linkage study
Objective: Familial aggregation of fibromyalgia has been increasingly recognized. The goal of the current study was to conduct a genome wide linkage scan to identify susceptibility loci for fibromyalgia. Methods: We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free..The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling
Arthritis & Rheumatism
Dec 2012
The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling
Objective: To elucidate whether the microRNA (miRNA) cluster miR-17-92 contributes to the activated phenotype of rheumatoid arthritis synovial fibroblasts (RASF). Methods: RASF were stimulated with tumor necrosis factor alpha (TNFα? and expression and regulation of the miR-17-92 cluster were studied using quantitative..TNF inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a TNF driven model of rheumatoid arthritis
Arthritis & Rheumatism
Dec 2012
TNF inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a TNF driven model of rheumatoid arthritis
Objective: To investigate how TNF inhibiting therapy effects bone destruction and inflammation in a TNF-driven animal model of rheumatoid arthritis. Methods: To evaluate the influence of TNF on osteoclastogenesis in vitro, we added different concentrations of TNF to spleen cell derived monocytes in the absence or..Alcam Regulates Long-term Hematopoietic Stem Cell Engraftment and Self-Renewal
Stem Cells
Dec 2012
Alcam Regulates Long-term Hematopoietic Stem Cell Engraftment and Self-Renewal
Hematopoietic stem cells (HSCs) reside in a specialized bone marrow (BM) microenvironment that supports the maintenance and functional integrity of long-term (LT)-HSCs throughout postnatal life. The objective of this work is to study the role of activated leukocyte cell adhesion molecule (Alcam) in HSC differentiation..An in vitro model of mesenchymal stem cell targeting using magnetic particle labelling
Journal of Tissue Engineering and Regenerative Medicine
Dec 2012
An in vitro model of mesenchymal stem cell targeting using magnetic particle labelling
The specific targeting of cells to sites of tissue damage in vivo is a major challenge precluding the success of stem cell-based therapies. Magnetic particle-based targeting may provide a solution. Our aim was to provide a model system to study the trapping and potential targeting of human mesenchymal stem cells (MSCs)..An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment
Journal of Internal Medicine
Dec 2012
An MRI-based index to measure the severity of Alzheimer's disease-like structural pattern in subjects with mild cognitive impairment
Background: Structural magnetic resonance imaging (MRI) is sensitive to neurodegeneration and can be used to estimate the risk of converting to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Brain changes in AD and prodromal AD involve a pattern of widespread atrophy. The use of..Assessment of the Cerebral Circulation in Adults with Coarctation of the Aorta
Congenital Heart Disease
Dec 2012
Assessment of the Cerebral Circulation in Adults with Coarctation of the Aorta
Aims: There is a fivefold increase in the frequency of intracranial aneurysm (IA) in adults with coarctation of the aorta (CoA). Current guidelines for management of adults with CoA recommend computed tomography angiography (CTA) or magnetic resonance imaging of the intracranial vessels. However, this recommendation..Atrial Tachyarrhythmias and the Cox-maze Procedure in Congenital Heart Disease
Congenital Heart Disease
Dec 2012
Atrial Tachyarrhythmias and the Cox-maze Procedure in Congenital Heart Disease
Introduction: Atrial tachyarrhythmias, particularly atrial flutter and fibrillation, are commonly associated with congenital heart disease and are a major cause of morbidity and mortality. The Cox-maze procedure, introduced by Dr. James Cox in 1987, is effective at controlling atrial fibrillation in structurally normal..Coagulation and cancer: biological and clinical aspects
Journal of Thrombosis and Haemostasis
Dec 2012
Coagulation and cancer: biological and clinical aspects
Malignancy affects the haemostatic system and the haemostatic system affects malignancy. In cancer patients there are a number of coagulation abnormalities which provide the background for an increased tendency of these patients to both thrombosis and haemorrhages. The causes of this coagulation impairment rely on..Doppler study of the fetal vertebral and middle cerebral arteries in fetuses with normal and increased umbilical artery resistance indices
Journal of Clinical Ultrasound
Dec 2012
Doppler study of the fetal vertebral and middle cerebral arteries in fetuses with normal and increased umbilical artery resistance indices
Objective: To compare the brain sparing mechanism of the fetal vertebral artery (VA), with the one of the middle cerebral artery (MCA) in fetuses with increased umbilical artery (UA) Doppler impedance. Method: We retrospectively studied 1084 Doppler examinations of the VA, MCA and UA performed in 1084 fetuses between..Doppler Tissue Imaging Provides an Estimate of Pulmonary Arterial Pressure in Children with Pulmonary Hypertension Due to Congenital Intracardiac Shunts
Congenital Heart Disease
Dec 2012
Doppler Tissue Imaging Provides an Estimate of Pulmonary Arterial Pressure in Children with Pulmonary Hypertension Due to Congenital Intracardiac Shunts
Objective: The aim of this study is to determine the relationship between the cardiac catheterization findings and pulsed-wave (PW) Doppler and Doppler tissue imaging (DTI) in pulmonary arterial hypertension patients with congenital heart disease with intracardiac shunts. Design and Patients: The present study aims to..Evolution of overweight prevalence among 5–6-year-old children according to socio-economic status
Acta Paediatrica
Dec 2012
Evolution of overweight prevalence among 5–6-year-old children according to socio-economic status
Aim: To assess time trends in overweight and obesity prevalence among 5–6-year-old children of Bordeaux city (France) over seven school years from 2004–2005 to 2010–2011. Methods: For each year, all 5–6-year-old children from 63 of the 69 schools of Bordeaux were included: 2005, 2100, 2010, 1952, 2040, 2017 and 2111..Extremely low birthweight infants: how neonatal intensive care unit teams can reduce postnatal malnutrition and prevent growth retardation
Acta Paediatrica
Dec 2012
Extremely low birthweight infants: how neonatal intensive care unit teams can reduce postnatal malnutrition and prevent growth retardation
Aim: To evaluate the impact of an improved nutritional policy for extremely low birthweight (ELBW) infants on nutritional deficits and postnatal growth. Method: We compared two groups of 37 ELBW infants, born before and after the introduction of an improved nutritional policy in April 2006. Group A (born 2005 to early..Facilitators of and Barriers to Advance Care Planning in Adult Congenital Heart Disease
Congenital Heart Disease
Dec 2012
Facilitators of and Barriers to Advance Care Planning in Adult Congenital Heart Disease
Background: Most adults with congenital heart disease (CHD) are interested in discussing matters related to advance care planning (ACP) early in the disease course, yet few such conversations actually occur. We aimed to evaluate factors that impact these discussions between patients and adult CHD providers. Methods:..Hospital-wide breastfeeding rates vs. breastmilk provision for very-low-birth-weight infants
Acta Paediatrica
Dec 2012
Hospital-wide breastfeeding rates vs. breastmilk provision for very-low-birth-weight infants
Aim: To investigate the relationship between breastmilk feeding in very-low-birth-weight infants in the neonatal intensive care unit and breastmilk feeding rates for all newborns by hospital. Methods: This was a cross-sectional study of 111 California hospitals in 2007 and 2008. Correlation coefficients were calculated..Human pluripotent stem cell models of Fanconi Anaemia deficiency reveal an important role for Fanconi Anaemia proteins in cellular reprogramming and survival of haematopoietic progenitors
Stem Cells
Dec 2012
Human pluripotent stem cell models of Fanconi Anaemia deficiency reveal an important role for Fanconi Anaemia proteins in cellular reprogramming and survival of haematopoietic progenitors
Fanconi anemia (FA) is a genomic instability disorder caused by mutations in genes involved in replication-dependant-repair and removal of DNA crosslinks. Mouse models with targeted deletions of FA genes have been developed; however none of these exhibit the human bone marrow aplasia. Human embryonic stem cell (hESC)..Impaired Cognitive Function and Reduced Anxiety-Related Behavior in a Promyelocytic Leukemia (PML) Tumor Suppressor Protein-Deficient Mouse
Genes, Brain and Behavior
Dec 2012
Impaired Cognitive Function and Reduced Anxiety-Related Behavior in a Promyelocytic Leukemia (PML) Tumor Suppressor Protein-Deficient Mouse
The promyelocytic leukemia protein (PML) is a tumor suppressor factor mostly known by its involvement in acute promyelocytic leukemia (APL). Interestingly, recent studies have provided evidence that, in the central nervous system, PML is involved in neurogenesis. However, prospective studies of PML in brain are..Improving cellular uptake and in-vivo tumor suppression efficacy of liposomal oligonucleotides by urea as a chemical penetration enhancer
The Journal of Gene Medicine
Dec 2012
Improving cellular uptake and in-vivo tumor suppression efficacy of liposomal oligonucleotides by urea as a chemical penetration enhancer
Background: Liposomes are among the most widely used carriers for delivery of antisense oligonucleotides (AsODNs) to intracellular targets. Although different strategies have been employed, the question of how to improve liposomal uptake and enhance the release of AsODN into cytoplasm is still remained to be completely..Introduction of the German case tariff fee system and its effects on patient satisfaction in inpatient naturopathy
European Journal of Integrative Medicine
Dec 2012
Introduction of the German case tariff fee system and its effects on patient satisfaction in inpatient naturopathy
Introduction: For certain indications, methods of classical naturopathy are now being used in German hospitals originally dedicated to the treatment of acute conditions using orthodox medicine. Because the hospital sector currently represents the focal point of German healthcare, both professionally and economically,..Is there any correlation between HLA-DR expression in laryngeal mucosa and interleukin gene variation in sudden infant death syndrome?
Acta Paediatrica
Dec 2012
Is there any correlation between HLA-DR expression in laryngeal mucosa and interleukin gene variation in sudden infant death syndrome?
Aim: The mucosal immune system and cytokines are activated in a large proportion of cases of sudden infant death syndrome (SIDS). Our aim was to search for a possible association between cytokine polymorphisms and immune stimulation of the laryngeal mucosal in SIDS. Methods: HLA-DR expression in laryngeal mucosal..Microparticle-associated tissue factor activity in patients with pancreatic cancer: Correlation with clinicopathological features
European Journal of Clinical Investigation
Dec 2012
Microparticle-associated tissue factor activity in patients with pancreatic cancer: Correlation with clinicopathological features
Background: Patients with pancreatic cancer have an unfavorable prognosis. A central role in pancreatic cancer progression has been suggested for tissue factor (TF), the main initiator of the blood coagulation cascade. We hypothesized that elevated levels of plasma microparticle (MP)-associated TF activity might..New Developments in the Area of Factor XIII
Journal of Thrombosis and Haemostasis
Dec 2012
New Developments in the Area of Factor XIII
Coagulation factor XIII (FXIII) is best known for its role in fibrin stabilization and crosslinking of antifibrinolytic proteins to the fibrin clot. From patients with congenital FXIII deficiency it was known that FXIII also has important functions in wound healing and maintaning pregnancy. Over the last decade more..Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting
International Journal of Laboratory Hematology
Dec 2012
Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting
Introduction: The CELL-DYN Emerald is a compact bench-top hematology analyzer that can be used for a three-part white cell differential analysis. To determine its utility for analysis of human and mouse samples, we evaluated this machine against the larger CELL-DYN Sapphire and Sysmex XT2000iV hematology analyzers...Pertinence of the Sysmex XE-5000™ parameters: rule of slide review in a context of ‘normal’ lymphocyte count (defined from control and mantle cell lymphoma blood specimens)
International Journal of Laboratory Hematology
Dec 2012
Pertinence of the Sysmex XE-5000™ parameters: rule of slide review in a context of ‘normal’ lymphocyte count (defined from control and mantle cell lymphoma blood specimens)
Introduction: As most hematology cell analyzers, the different parameters of Sysmex XE-5000™ are little informative in the qualitative analysis of lymphoid cells, and especially when the lymphocyte count is below 4 × 109/L (i.e., ‘normal’). The aim of our study was to investigate whether some parameters and/or ‘flags’..Physical and social functioning in adolescents with rheumatological conditions: a study of predictors
Acta Paediatrica
Dec 2012
Physical and social functioning in adolescents with rheumatological conditions: a study of predictors
Aim: This study examines possible predictors of physical and social functioning in adolescents with rheumatological conditions. Condition-related variables and psychosocial variables were studied, and their relative contribution as predictors was examined. Methods: The study population was one hundred and twelve..Preterm birth and unintentional injuries: risks to children, adolescents and young adults show no consistent pattern
Acta Paediatrica
Dec 2012
Preterm birth and unintentional injuries: risks to children, adolescents and young adults show no consistent pattern
Aim: Preterm birth is associated with a number of physical and mental health issues. The aim of this study was to find out whether there was also any association between individuals born preterm in Sweden between 1984 and 2006 and the risk of unintentional injuries during childhood, adolescence and young adulthood...Rituximab for thrombotic thrombocytopenic purpura (TTP): benefit of early administration during acute episodes and use of prophylaxis to prevent relapse
Journal of Thrombosis and Haemostasis
Dec 2012
Rituximab for thrombotic thrombocytopenic purpura (TTP): benefit of early administration during acute episodes and use of prophylaxis to prevent relapse
Background: Rituximab has been documented in the treatment of acute (≤3 days from admission), relapsed/refractory TTP and given as prophylaxis in selected cases to prevent acute relapse. The precise timing of Rituximab in acute TTP has not been determined. Objective: To perform a retrospective analysis of rituximab use..Self-rated and parent-rated quality of life (QoL) for community-based obese and overweight children
Acta Paediatrica
Dec 2012
Self-rated and parent-rated quality of life (QoL) for community-based obese and overweight children
Aims: To determine the effects of being obese or overweight on quality of life (QoL) of children from a community-based sample and to compare their self-ratings of QoL with their parents' ratings for their children's QoL. Methods: Dyads of 8- to 12-year-old children [60 obese, 34 overweight and 127 normal weight (N =..The American Heart Association's Recent Scientific Statement on Cardiac Critical Care: Implications for Pediatric Practice
Congenital Heart Disease
Dec 2012
The American Heart Association's Recent Scientific Statement on Cardiac Critical Care: Implications for Pediatric Practice
A writing group sponsored by the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the Council on Quality of Care and Outcomes Research of The American Heart Association has recently formulated a roadmap to meet the..The combination of IKKβ inhibitor and everolimus modulates expression of IL-10 in HTLV-1-infected T cells
Immunology
Dec 2012
The combination of IKKβ inhibitor and everolimus modulates expression of IL-10 in HTLV-1-infected T cells
Adult T-cell leukemia-lymphoma (ATLL) is an aggressive malignancy of CD4+/CD25+ T lymphocytes, and characterized with severely compromised immunosystem in which the human T-cell lymphotropic virus type 1 (HTLV-1) has been recognized as the etiologic agent. This study found that an IκB kinase β (IKKβ) inhibitor..The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB/c mice
Parasite Immunology
Dec 2012
The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB/c mice
Toxoplasmosis is a world-wide zoonosis that causes significant public health and veterinary problems. The study of vaccines remains the most promising method for the future prevention and control of toxoplasmosis. Recombinant Toxoplasma gondii cyclophilin has been shown to have potent PPIase and IL-12-inducing..The use of placebo interventions in clinical practice
Complementary Therapies in Medicine
Dec 2012
The use of placebo interventions in clinical practice
Although a considerable number of mostly quantitative surveys have investigated the frequency and circumstances of the use of placebo interventions in clinical practice, it remains rather unclear what role placebo interventions really have outside clinical and laboratory research and why they are used. In this article..Thymosin Β4 Protects C57bl/6 Mice From Bleomycin-Induced Damage In The Lung
European Journal of Clinical Investigation
Dec 2012
Thymosin Β4 Protects C57bl/6 Mice From Bleomycin-Induced Damage In The Lung
Background: Thymosin β4 (Tβ4) was recently found at high concentration in the bronchoalveolar lavage fluid (BALF) of scleroderma patients with lung involvement. It has been hypothesized that Tβ4 may exert a cyto-protective effect during lung injury since lower Tβ4 levels were associated with interstitial lung disease..Transesophageal Echocardiography Probe Insertion Failure in Infants Undergoing Cardiac Surgery
Congenital Heart Disease
Dec 2012
Transesophageal Echocardiography Probe Insertion Failure in Infants Undergoing Cardiac Surgery
Background: The use of intraoperative transesophageal echocardiography (iTEE) in neonates ≤4 kg has not been systematically described. We sought to describe the use of and determine risk factors for iTEE probe insertion failure in small infants. We also sought to develop an algorithm for predicting the likelihood of..Phenolic composition and in vitro activity of the Brazilian fruit tree Caryocar coriaceum Wittm.
European Journal of Integrative Medicine
Dec 2012
Phenolic composition and in vitro activity of the Brazilian fruit tree Caryocar coriaceum Wittm.
Introduction: Caryocar coriaceum Wittm. (Caryocaraceae) is a plant found in the region of Araripe (Ceará State, Brazil) and is widely used in folk medicine. The present work aimed to evaluate the chemical composition and synergistic–antibiotic activity of a hydroethanol leaf extract (LECC) and a methanol fraction..Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice
European Journal of Immunology
Dec 2012
Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice
We previously established an IgG Fc receptor IIB (FcγRIIB)-deficient C57BL/6 (B6)-congenic mouse strain (KO1), which spontaneously develops rheumatoid arthritis (RA), but not systemic lupus erythematosus (SLE). Here we show that when Y chromosome-linked autoimmune acceleration (Yaa) mutation was introduced in KO1..Physical Activity Behavior Two to Six Years Following Cardiac Rehabilitation: A Socioecological Analysis
Clinical Cardiology
Dec 2012
Physical Activity Behavior Two to Six Years Following Cardiac Rehabilitation: A Socioecological Analysis
Background: Cardiac rehabilitation (CR) promotes long-term positive health behaviours, such as physical activity (PA), in patients following a cardiovascular event. We have limited knowledge of long-term PA and its correlates. Therefore, this research examined both PA behaviour and socioecological correlates among..Prospective, multicenter validation of prediction scores for major bleeding in elderly patients with venous thromboembolism
Journal of Thrombosis and Haemostasis
Dec 2012
Prospective, multicenter validation of prediction scores for major bleeding in elderly patients with venous thromboembolism
Background: The Outpatient Bleeding Risk Index (OBRI) and the Kuijer, RIETE, and Kearon scores are clinical prognostic scores for bleeding in patients receiving oral anticoagulants for venous thromboembolism (VTE). We prospectively compared the performance of these scores in elderly patients with VTE. Methods: In a..Public health ethics for complementary and alternative medicine
European Journal of Integrative Medicine
Dec 2012
Public health ethics for complementary and alternative medicine
CAMbrella (2010–2012), a EU-funded project on complementary and alternative medicine focused on, amongst other topics, EU citizens’ needs and attitudes to complementary and alternative medicine (CAM). Three important themes relating to this topic were identified: citizens’ access to CAM in European countries,..Randomised controlled trials of homeopathy in humans: characterising the research journal literature for systematic review
Homeopathy
Dec 2012
Randomised controlled trials of homeopathy in humans: characterising the research journal literature for systematic review
Introduction: A new programme of systematic reviews of randomised controlled trials (RCTs) in homeopathy will distinguish important attributes of RCT records, including: placebo controlled versus other-than-placebo (OTP) controlled; individualised versus non-individualised homeopathy; peer-reviewed (PR) versus non..Rebound exacerbation multiple sclerosis following cessation of oral treatment
Multiple Sclerosis and Related Disorders
Dec 2012
Rebound exacerbation multiple sclerosis following cessation of oral treatment
Background: Multiple sclerosis (MS) management is changing, revolutionized by oral agents. Immune Reconstitution Inflammatory Syndrome (IRIS) describes exaggerated response to both exogenous (infective) and endogenous (non-infective) antigens. Methods: This paper reports two cases of MS “rebound” following withdrawal..Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome
Clinical & Experimental Immunology
Dec 2012
Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome
Primary Sjögren's syndrome (pSS) is characterised by the presence of autoantibodies against the ribonucleoprotein (RNP) particles Ro/SSA and La/SS-B, and mononuclear cell infiltration of exocrine tissues, especially salivary and lachrymal glands. Low numbers of autoantigen-specific memory B cells and elevated levels of..Roles of repressive epigenetic machinery in lineage decision of T cells
Immunology
Dec 2012
Roles of repressive epigenetic machinery in lineage decision of T cells
DNA methylation and histone modifications are central to epigenetic gene regulation, which has been shown to play a crucial role in development. Epigenetics has often been discussed in the context of the maintenance of cell identity due to its heritable nature of gene expression status. Indeed, crucial roles of the..Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome
European Journal of Immunology
Dec 2012
Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome
In a recent report we demonstrated that distinct members of the secreted aspartic protease (Sap) family of Candida albicans are able to induce secretion of proinflammatory cytokines by human monocytes, independently of their proteolytic activity and specific pH optima. In particular, Sap2 and Sap6 potently induced..Severe Sepsis in Do-not-resuscitate Patients: Intervention and Mortality Rates
Journal of Emergency Medicine
Dec 2012
Severe Sepsis in Do-not-resuscitate Patients: Intervention and Mortality Rates
Background: Severe sepsis is a high-mortality disease, and early resuscitation decreases mortality. Do-not-resuscitate (DNR) status may influence physician decisions beyond cardiopulmonary resuscitation, but this has not been investigated in sepsis. Objective: Among Emergency Department (ED) severe sepsis patients,..Sevoflurane Confers Additive Cardioprotection to Ethanol Preconditioning Associated With Enhanced Phosphorylation of Glycogen Synthase Kinase-3β and Inhibition of Mitochondrial Permeability Transition Pore Opening
Journal of Cardiothoracic and Vascular Anesthesia
Dec 2012
Sevoflurane Confers Additive Cardioprotection to Ethanol Preconditioning Associated With Enhanced Phosphorylation of Glycogen Synthase Kinase-3β and Inhibition of Mitochondrial Permeability Transition Pore Opening
Objective: The purposes of this study were to investigate whether sevoflurane (SEVO) enhances moderate-dose ethanol (EtOH) preconditioning and whether this additional cardioprotection is associated with glycogen synthase kinase-3β (GSK-3β), protein kinase B (Akt), mammalian target of rapamycin (mTOR), 70-kDa ribosomal..Short-term evaluation of electromagnetic field pretreatment of adipose-derived stem cells to improve bone healing
Journal of Tissue Engineering and Regenerative Medicine
Dec 2012
Short-term evaluation of electromagnetic field pretreatment of adipose-derived stem cells to improve bone healing
An electromagnetic field is an effective stimulation tool because it promotes bone defect healing, albeit in an unknown way. Although electromagnetic fields are used for treatment after surgery, many patients prefer cell-based tissue regeneration procedures that do not require daily treatments. This study addressed the..Th17 cells contribute to anti-tumor immunity and promote the recruitment of th1 cells to the tumor
Immunology
Dec 2012
Th17 cells contribute to anti-tumor immunity and promote the recruitment of th1 cells to the tumor
T helper 17 lymphocytes (Th17) are found in high frequency in tumor-burdened animals and cancer patients. These lymphocytes, characterized by the production of IL-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies, however their function in..The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation
Clinical & Experimental Immunology
Dec 2012
The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation
Recent studies indicate that chemotherapeutic agents may increase the anti-tumoral immune response. Based on the pivotal role of dendritic cells (DCs) in host tumour-specific immune responses, we investigated the effect of commonly used chemotherapeutic drugs Dexamethasone, Doxorubicin, Cisplatin and Irinotecan and..Unsupervised Virtual Reality-Based Exercise Program Improves Hip Muscles Strength and Balance Control in the Elderly: A Pilot Study
Archives of Physical Medicine and Rehabilitation
Dec 2012
Unsupervised Virtual Reality-Based Exercise Program Improves Hip Muscles Strength and Balance Control in the Elderly: A Pilot Study
Objective: To assess the effects of an unsupervised virtual reality (VR)-based exercise program on hip muscles strength and balance control in the elderly. Design: Controlled cohort repeated-measures experimental design, a pilot study Setting: University research laboratory Participants: Thirty-two ambulatory older..Usefulness of a Myofascial Trigger Point Injection for Groin Pain in patients with CP/CPPS: A Pilot Study
Archives of Physical Medicine and Rehabilitation
Dec 2012
Usefulness of a Myofascial Trigger Point Injection for Groin Pain in patients with CP/CPPS: A Pilot Study
Objective: To investigate the therapeutic effectiveness of trigger point injection into the muscles around the groin in patients with a clinically diagnosed chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Design: Prospective, unicenter trial. Setting: University rehabilitation hospital. Participants:..A randomized, double-blind, crossover, placebo-controlled comparative clinical trial of arginine aspartate plus adenosine monophosphate for the intermittent treatment of male erectile dysfunction
Andrology
Dec 2012
A randomized, double-blind, crossover, placebo-controlled comparative clinical trial of arginine aspartate plus adenosine monophosphate for the intermittent treatment of male erectile dysfunction
Efficacy and safety of l-arginine aspartate 8 g combined with 200 mg of adenosine monophosphate (AA) with placebo (PL) alone for intermittent treatment of mild-to-moderate erectile dysfunction (ED) were compared. The study design was a double-blind, PL-controlled, two-way crossover randomized clinical trial with 26..Active management of selective intrauterine growth restriction with abnormal Doppler in monochorionic diamniotic twin pregnancies diagnosed in the second trimester of pregnancy
Prenatal Diagnosis
Dec 2012
Active management of selective intrauterine growth restriction with abnormal Doppler in monochorionic diamniotic twin pregnancies diagnosed in the second trimester of pregnancy
Objective: This study aims to compare outcomes of active management of monochorionic diamniotic twin pregnancies complicated with severe intrauterine growth restriction (IUGR) of one twin before 24 weeks with continuous or intermittent absent or reversed end-diastolic flow (AREDF) in the umbilical artery, with or..Auricular cartilage repair using cryogel scaffolds loaded with BMP-7-expressing primary chondrocytes
Journal of Tissue Engineering and Regenerative Medicine
Dec 2012
Auricular cartilage repair using cryogel scaffolds loaded with BMP-7-expressing primary chondrocytes
The loss of cartilage tissue due to trauma, tumour surgery or congenital defects, such as microtia and anotia, is one of the major concerns in head and neck surgery. Recently tissue-engineering approaches, including gene delivery, have been proposed for the regeneration of cartilage tissue. In this study, primary..B-cell receptor signal strength influences terminal differentiation
European Journal of Immunology
Dec 2012
B-cell receptor signal strength influences terminal differentiation
B-cell terminal differentiation into antibody secreting plasma cells (PCs) features a transcriptional shift driven by the activation of plasma cell lineage determinants such as Blimp-1 and Xbp-1, together with the extinction of Pax5. Little is known about the signals inducing this change in transcriptional networks and..CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant natural killer T (iNKT) cells
European Journal of Immunology
Dec 2012
CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant natural killer T (iNKT) cells
Isoglobotrihexosylceramide (iGb3) has been identified as a potent CD1d-presented self-antigen for mouse iNKT cells. The role of iGb3 in humans remains unresolved, however, as there have been conflicting reports about iGb3-dependent human iNKT-cell activation, and humans lack iGb3 synthase, a key enzyme for iGb3..Chemokine Programming Dendritic Cell Antigen Response: Part I – Select Chemokine Programming of Antigen Uptake Even After Maturation
Immunology
Dec 2012
Chemokine Programming Dendritic Cell Antigen Response: Part I – Select Chemokine Programming of Antigen Uptake Even After Maturation
Here, we report on the successful of programming of dendritic cells (DCs) using selectively applied mixtures of chemokines as a novel protocol for engineering vaccine efficiency. Antigen internalization of DCs is a pivotal step in antigen uptake/presentation for bridging innate and adaptive immunity and in exogenous..Chemokine Programming Dendritic Cell Antigen Response: Part II - Programming Antigen Presentation to T Lymphocytes by Partially Maintaining Immature Dendritic Cell Phenotype
Immunology
Dec 2012
Chemokine Programming Dendritic Cell Antigen Response: Part II - Programming Antigen Presentation to T Lymphocytes by Partially Maintaining Immature Dendritic Cell Phenotype
In a companion article to this study,1 the successful programming of a JAWSII dendritic cell (DC) line's antigen uptake and processing was demonstrated based on pre-treatment of DCs with a specific “cocktail” of select chemokines. Chemokine pre-treatment modulated cytokine production before and after DC maturation (by..Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases
European Journal of Immunology
Dec 2012
Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases
Conditional ligands have enabled the high-throughput production of Human Leukocyte Antigen (HLA) libraries that present defined peptides. Immunomonitoring platforms typically concentrate on restriction elements associated with European ancestry, and such tools are scarce for Asian HLA variants. We report thirty novel..CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner
European Journal of Immunology
Dec 2012
CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner
Macrophages provide a first line of defense against bacterial infection by engulfing and killing invading bacteria, but intracellular bacteria such as Listeria monocytogenes (LM) can survive in macrophages by various mechanisms of evasion. CRIg, a C3b receptor, binds to C3b on opsonized bacteria and facilitates..Cytomegalovirus-specific T cells are detectable in early childhood and allow assignment of the infection status in children with passive maternal antibodies
European Journal of Immunology
Dec 2012
Cytomegalovirus-specific T cells are detectable in early childhood and allow assignment of the infection status in children with passive maternal antibodies
Serological identification of the cytomegalovirus (CMV) status in children <18 months of age is complicated by the variable persistence of maternal antibodies. As T cells are not passively transferred, we attempted to assess whether CMV-specific cellular immunity may be superior to determine the actual CMV-status; we..Dendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cells
Immunology
Dec 2012
Dendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cells
Plasmacytoid dendritic cells (pDC) in mesenteric lymph nodes (MLN) may be important regulators of both inflammatory and non-inflammatory mucosal immune responses but human studies are rare. Here we compare pDC from human MLN and peripheral blood (PB) by phenotype and function. MLN from patients with or without..Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli
Clinical & Experimental Immunology
Dec 2012
Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli
Probiotics are live microorganisms, which have beneficial effects on the host when ingested in adequate amounts. Probiotic bacteria may stimulate immune effector functions in a strain specific manner. In this blind placebo-controlled trial, we investigated the effects on the immune system following daily intake of six..Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation
European Journal of Immunology
Dec 2012
Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation
The roles of Th17 cells and IL-21 in the pathogenesis of chronic graft-versus-host disease (cGVHD) in patients who undergo allogeneic transplantation are still unknown. Here, we examined this question by monitoring eight patients with new-onset cGVHD for the presence of Th17 cells, Th1 cells and IL-21. Allografts from..Dual role of IL-10 in the regulation of Respiratory Syncitial Virus (RSV)-induced lung inflammation
Clinical & Experimental Immunology
Dec 2012
Dual role of IL-10 in the regulation of Respiratory Syncitial Virus (RSV)-induced lung inflammation
RSV lower respiratory tract infections (LRTI) are among the most common diseases necessitating hospital admission in children. In addition to causing acute respiratory failure, RSV infections are associated with sequelae such as secondary bacterial infections and reactive airway disease. One characteristic host..Effects of woodland walking on salivary stress markers cortisol and chromogranin A
Complementary Therapies in Medicine
Dec 2012
Effects of woodland walking on salivary stress markers cortisol and chromogranin A
Objective: We investigated the effect of walking through woodland on salivary endocrinological stress markers, cortisol and chromogranin A (CgA). Design: From 20 healthy males, saliva samples were collected immediately before and after the walk, and 20min and 40min after that. In addition, using visual analog scales,..Emergency Department Management of Pediatric Patients with Cyanotic Heart Disease and Fever
Journal of Emergency Medicine
Dec 2012
Emergency Department Management of Pediatric Patients with Cyanotic Heart Disease and Fever
Background: Children with cyanotic congenital heart disease (CCHD) are living longer and presenting to the Emergency Department (ED) in larger numbers. A greater understanding of their diagnoses and appropriate management strategies can improve outcomes. Objective: Our objective was to describe the ED diagnoses,..Emergency Department Vancomycin Use: Dosing Practices and Associated Outcomes
Journal of Emergency Medicine
Dec 2012
Emergency Department Vancomycin Use: Dosing Practices and Associated Outcomes
Background: Emergency Department (ED) dosing of vancomycin and its effect on outcomes has not been examined. Study Objective: To describe current vancomycin dosing practices for ED patients, focusing on patient factors associated with administration, dosing accuracy based on patient body weight, and clinical outcomes...Emotional Vitality: Concept of Importance for Rehabilitation
Archives of Physical Medicine and Rehabilitation
Dec 2012
Emotional Vitality: Concept of Importance for Rehabilitation
Objective: To provide a framework for the conceptualization of emotional vitality as an important construct for rehabilitation professionals. The specific objectives are to outline the existing scope and breadth of knowledge currently available regarding the definition and measurement of emotional vitality in persons..Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or ‘when stochasticity completes randomness’
Immunology
Dec 2012
Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or ‘when stochasticity completes randomness’
To perform their specific functional role, B and T lymphocytes, cells of the adaptive immune system of jawed vertebrates, need to express one (and, preferably, only one) form of antigen receptor, i.e., the immunoglobulin (Ig) or T cell receptor (TCR), respectively. This end goal depends initially on a series of DNA..Glass Intact Assures Safe Cervical Spine Protocol
Journal of Emergency Medicine
Dec 2012
Glass Intact Assures Safe Cervical Spine Protocol
Background: Selective cervical spine immobilization performed by Emergency Medical Services (EMS) is being utilized with increasing frequency. These protocols, although very sensitive, still include subjective data such as “mild cervical discomfort.” The aim of this study is to create an objective clinical decision..Hepatitis B Screening in US Travelers Seen at the Boston Area Travel Medicine Network
Journal of Travel Medicine
Dec 2012
Hepatitis B Screening in US Travelers Seen at the Boston Area Travel Medicine Network
Background: Persons born in countries with hepatitis B surface antigen (HBsAg) prevalence ≥2% have increased risk for unrecognized hepatitis B virus (HBV) infection. Testing at pre-travel consultations is a strategy to identify previously undiagnosed HBV infections. Using records of travelers seen at the Boston Area..Human Mesenchymal Stem Cells suppress donor CD4+ T cell proliferation and reduce pathology in a humanised mouse model of acute Graft versus Host Disease
Clinical & Experimental Immunology
Dec 2012
Human Mesenchymal Stem Cells suppress donor CD4+ T cell proliferation and reduce pathology in a humanised mouse model of acute Graft versus Host Disease
Acute graft versus host disease (aGvHD) is a life threatening complication following allogeneic haematopoietic stem cell transplantation (HSCT), occurring in up to 30-50% of patients who receive HLA-matched sibling transplants. Current therapies for steroid refractory aGvHD are limited, with the prognosis of patients..IL-21 synergises with IL-2 to enhance TCR-induced human T cell proliferation and counteracts IL-2/TGF-β-induced regulatory T cell development
Immunology
Dec 2012
IL-21 synergises with IL-2 to enhance TCR-induced human T cell proliferation and counteracts IL-2/TGF-β-induced regulatory T cell development
IL-2 is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T cells (Treg) development. IL-21 is a type-I cytokine acting as a potent T cell co-mitogen but less efficient than IL-2 in sustaining T cell proliferation...Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study
Journal of Cardiothoracic and Vascular Anesthesia
Dec 2012
Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study
Objective: Acidosis produces a negative inotropic effect on cardiac muscle against which catecholamines and phosphodiesterase III inhibitors have limited therapeutic effects. This study evaluated the effects of colforsin, which directly activates adenylate cyclase without β-adrenergic receptor activation, in isolated..Inhaled Dornase alfa (Pulmozyme) as a noninvasive treatment of atelectasis in mechanically ventilated patients
Journal of Critical Care
Dec 2012
Inhaled Dornase alfa (Pulmozyme) as a noninvasive treatment of atelectasis in mechanically ventilated patients
Background: Lobar or segmental collapse of the lung in mechanically ventilated patients is a common occurrence in the intensive care unit. Management is labor and time intensive and not highly effective. Methods: We conducted a randomized, placebo-controlled, double-blind pilot study to determine whether nebulized..Is it possible to individualize Intensity of Eccentric Cycling Exercise from Perceived Exertion on Concentric Test?
Archives of Physical Medicine and Rehabilitation
Dec 2012
Is it possible to individualize Intensity of Eccentric Cycling Exercise from Perceived Exertion on Concentric Test?
Objective: To assess the safety and acute effects of a procedure using perceived exertion during a prior submaximal concentric (CON) test to individualize eccentric (ECC) cycling exercise intensity. Design: Prospective monocentric open study. Setting: Technological Investigation Platform at the Physical Medicine and..Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components
Journal of Thrombosis and Haemostasis
Dec 2012
Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components
Background: Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate CS, dermatan sulfate DS) and expose extracellular matrix (ECM) proteins (e.g. decorin) at sites of fibrin formation. Objective: Here we address the effect of these vessel wall..Mechanism of the Inhibitory Effect of Electroacupuncture on Experimental Arrhythmias
Journal of Acupuncture and Meridian Studies
Dec 2012
Mechanism of the Inhibitory Effect of Electroacupuncture on Experimental Arrhythmias
Clinical observations reported that acupuncture can alleviate several kinds of arrhythmias. To explore its efficacy and mechanism, we have studied the electroacupuncture (EA) inhibition on experimental arrhythmias in rabbits since 1980s and analyzed its mechanism. These studies were mostly conducted in the Department..Naturopaths and Western herbalists’ attitudes to evidence, regulation, information sources and knowledge about popular complementary medicines
Complementary Therapies in Medicine
Dec 2012
Naturopaths and Western herbalists’ attitudes to evidence, regulation, information sources and knowledge about popular complementary medicines
Background: The practice of naturopathy and Western herbal medicine (WHM) was built on traditional evidence but may be undergoing change with the advent of scientific evidence. The aims of this research were to provide a better understanding of practitioners’ attitudes towards evidence, information sources,..Non-cardiac chest pain: time to extend the rapid access chest pain clinic?
International Journal of Clinical Practicece
Dec 2012
Non-cardiac chest pain: time to extend the rapid access chest pain clinic?
Non-cardiac chest pain is common. It has a low risk of coronary events, but causes considerable physical and social disability and inappropriate health-care usage. It is a heterogeneous condition, which may be caused by or associated with gastro-oesophageal, musculoskeletal or psychiatric abnormalities and sustained by..Osteocyte apoptosis
Bone
Dec 2012
Osteocyte apoptosis
Apoptotic death of osteocytes was recognized over 15years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen..Efficacy and safety of collagen matrix implants in phacotrabeculectomy, and comparison with mitomycin C augmented phacotrabeculetcomy at one year
Clinical & Experimental Ophthalmology
Dec 2012
Efficacy and safety of collagen matrix implants in phacotrabeculectomy, and comparison with mitomycin C augmented phacotrabeculetcomy at one year
Background: To assess the efficacy and safety of collagen matrix implant (Ologen TM) in phacotrabeculectomy surgeries in patients with primary glaucoma. Design: Prospective, non-randomized, comparative study. Participants: Sixty-six Asian patients undergoing phacotrabeculectomy. Methods: One eye of 33 consecutive..Is pre-operative ciliary body and iris anatomical configuration a predictor of malignant glaucoma development?
Clinical & Experimental Ophthalmology
Dec 2012
Is pre-operative ciliary body and iris anatomical configuration a predictor of malignant glaucoma development?
Background: To investigate anatomic configuration of ciliary body and iris, using ultrasound biomicroscopy (UBM), as a predictive factor for development of malignant glaucoma (MG). Design: Retrospective study in a tertiary care hospital. Participants: Cohort of 31 consecutive patients diagnosed with postsurgical MG...Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature
Clinical & Experimental Ophthalmology
Dec 2012
Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature
Background: Invasive fungal sinusitis is a rare condition that usually occurs in immuno-compromised patients and often presents as an orbital apex syndrome. It is frequently misdiagnosed on presentation and is almost always lethal without early treatment. Design: Retrospective case series of 14 consecutive patients..Adenosine and cAMP signaling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity
Immunology
Dec 2012
Adenosine and cAMP signaling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity
Multiple endogenous mechanisms that regulate immune and inflammatory processes contribute to the maintenance of peripheral tolerance and prevent chronic inflammation in mammals. Yet pathogens and tumors are able to exploit these homeostatic pathways to foster immunosuppressive microenvironments and evade immune..CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim
Immunology
Dec 2012
CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim
Extensive studies on CD4+CD25+ regulatory T (Treg) cells suggest they are important in regulating immune responses. However, mechanisms of peripheral Treg cell homeostasis are unknown. We found that stromal cells isolated from secondary lymphoid organs such as spleen and lymph nodes could support the survival of Treg..Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial
Clinical & Experimental Allergy
Dec 2012
Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial
Background: Obesity and asthma are associated conditions; however, the mechanisms linking the two remain unclear. Few studies have examined the effects of weight loss on inflammation and clinical outcomes in obese–asthma. Objective: To compare the effects of weight loss achieved by dietary restriction, exercise or..Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study
Clinical & Experimental Allergy
Dec 2012
Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study
Background: Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age. Objective: To explore the effects of geohelminth infections and age on atopy,..Heterogeneity in the responses of human lung mast cells to stem cell factor
Clinical & Experimental Allergy
Dec 2012
Heterogeneity in the responses of human lung mast cells to stem cell factor
Background: Stem cell factor (SCF) is a growth factor that is involved in mast cell differentiation and proliferation. SCF primes human lung mast cells for enhanced responses to IgE-directed activation but is not generally recognized as a direct activator. SCF mediates its effects through c-kit. Objective: The aim of..Impaired macrophage phagocytosis in non-eosinophilic asthma
Clinical & Experimental Allergy
Dec 2012
Impaired macrophage phagocytosis in non-eosinophilic asthma
Background: Many patients with non-eosinophilic asthma have increased numbers of neutrophils in the airways. The explanation for this chronic inflammation remains unclear, but may result from an impaired ability of alveolar macrophages to phagocytose apoptotic cells (a process termed ‘efferocytosis’), as we have shown..Local use of geographic information systems to improve data utilisation and health services: mapping caesarean section coverage in rural Rwanda
Tropical Medcine and International Health
Dec 2012
Local use of geographic information systems to improve data utilisation and health services: mapping caesarean section coverage in rural Rwanda
Objectives: To show the utility of combining routinely collected data with geographic location using a Geographic Information System (GIS) in order to facilitate a data-driven approach to identifying potential gaps in access to emergency obstetric care within a rural Rwandan health district. Methods: Total expected..Occupational exposures to aluminum and iron and risk of lung epithelium atypia in sudan
Diagnostic Cytopathology
Dec 2012
Occupational exposures to aluminum and iron and risk of lung epithelium atypia in sudan
This study investigated the risk of lung cytological atypical changes in regards to occupational exposure to aluminum and iron. Detailed job histories were elicited from 130 incident cases with confirmed exposure to aluminum (50) or iron (80) and 157 population controls (nonexposed). Cytological atypia in sputum..Peamaclein – A new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3
Clinical & Experimental Allergy
Dec 2012
Peamaclein – A new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3
Background: Among the peach-derived allergens which are already known, the lipid transfer protein (Pru p 3) seems to be the one to exert severe allergic reactions. Objective: To identify and characterize a new peach allergen causing a clinical picture similar to that of Pru p 3. Methods: Patients were selected on the..Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection
Clinical & Experimental Allergy
Dec 2012
Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection
Background: Modulation of the host immune response by helminths has been reported to be essential for parasite survival and also to benefit the host by suppressing inflammatory diseases such as allergies. We have previously shown that excretory-secretory products of Trichinella spiralis muscle larvae have..Ragweed pollen extract intensifies LPS-induced priming of NLRP3 inflammasome in human macrophages
Immunology
Dec 2012
Ragweed pollen extract intensifies LPS-induced priming of NLRP3 inflammasome in human macrophages
Ragweed pollen extract (RWE) has been described to possess intrinsic NADPH oxidase activity that induces oxidative stress by initiating the production of intracellular reactive oxygen species (ROS). ROS are important contributors to the manifestation of the allergic inflammation, furthermore, concomitant exposure to an..Specific Antibody Deficiency in Children with Recurrent Respiratory Infections: a Controlled Study with Follow-Up
Clinical & Experimental Immunology
Dec 2012
Specific Antibody Deficiency in Children with Recurrent Respiratory Infections: a Controlled Study with Follow-Up
Results: Specific antibody deficiency (SAD) to unconjugated pneumococcal vaccine (PPV) is an established primary B cell immunodeficiency. The occurrence and natural history of SAD in children is unclear. Background: We conducted an observational study to identify SAD in children with recurrent respiratory infections...Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: A double-blind, randomized, placebo-controlled trial
Stem Cells
Dec 2012
Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: A double-blind, randomized, placebo-controlled trial
Allogeneic umbilical cord blood (UCB) has therapeutic potential for cerebral palsy (CP). Concomitant administration of recombinant human erythropoietin (rhEPO) may boost the efficacy of UCB, as it has neurotrophic effects. The objectives of this study were to assess the safety and efficacy of allogeneic UCB potentiated..ALOX5 Polymorphism Associates with Increased Leukotriene Production and Reduced Lung Function and Asthma Control in Children with Poorly Controlled Asthma
Clinical & Experimental Allergy
Dec 2012
ALOX5 Polymorphism Associates with Increased Leukotriene Production and Reduced Lung Function and Asthma Control in Children with Poorly Controlled Asthma
Background: Identification of risk factors for reduced asthma control could improve the understanding and treatment of asthma. A promoter polymorphism in the 5-lipoxygenase gene affects gene expression and response to asthma therapy but its impact on disease control remains unclear. Objective: We sought to determine if..Levels of prostaglandin E2 and Cysteinyl-leukotrienes in sputum supernatant of patients with asthma: The effect of smoking
Clinical & Experimental Allergy
Dec 2012
Levels of prostaglandin E2 and Cysteinyl-leukotrienes in sputum supernatant of patients with asthma: The effect of smoking
Background: Smoking is associated with worse asthma outcomes and may modify airways inflammation. Such modification may be mediated through an effect on prostaglandin E2 (PGE2) and cysteinyl leukotrienes (Cyst-LTs). Objective: We aimed to determine the levels of both PGE2 and Cyst-LTs in sputum supernatants of patients..Neonatal and parental predictors of executive function in very preterm children
Acta Paediatrica
Dec 2012
Neonatal and parental predictors of executive function in very preterm children
Aim: To examine neonatal and parental predictors of executive function in very preterm (gestational age ≤30 weeks) children aged 4.0–12.0 years. Methods: Two-hundred very preterm (mean age 8.2 ± 2.5 years) children without severe disabilities, born between 1996 and 2004, were assessed with measures of executive..A randomised comparison of variable-frequency automated mandatory boluses with a basal infusion for patient-controlled epidural analgesia during labour and delivery
Anaesthesia
Dec 2012
A randomised comparison of variable-frequency automated mandatory boluses with a basal infusion for patient-controlled epidural analgesia during labour and delivery
This trial was conducted to compare the analgesic efficacy of administering variable-frequency automated boluses at a rate proportional to the patient's needs with fixed continuous basal infusion in patient-controlled epidural analgesia (PCEA) during labour and delivery. We recruited a total of 102 parturients in..A structured educational intervention to improve targeted temperature management utilization after cardiac arrest
Journal of Critical Care
Dec 2012
A structured educational intervention to improve targeted temperature management utilization after cardiac arrest
Purpose: Post-arrest targeted temperature management (TTM) has been shown to dramatically improve outcomes after resuscitation, yet studies have revealed inconsistent and slow adoption. Little is known about barriers to TTM implementation and methods to increase adoption. We hypothesized that a structured educational..Clinical epidemiology of central venous catheter–related bloodstream infections in an intensive care unit in China
Journal of Critical Care
Dec 2012
Clinical epidemiology of central venous catheter–related bloodstream infections in an intensive care unit in China
Background: Central venous catheters (CVCs) are universally used during the treatment of critically ill patients. Their use, however, is associated with a substantial infection risk. At present, there are few studies on catheter-related bloodstream infections (CRBSIs) that are comparable with international similar..Comparison of the effects of vapocoolant spray and topical anesthetic cream on pain during needle electromyography in the medial gastrocnemius
Archives of Physical Medicine and Rehabilitation
Dec 2012
Comparison of the effects of vapocoolant spray and topical anesthetic cream on pain during needle electromyography in the medial gastrocnemius
Objective(s): To compare the effects of a vapocoolant spray and a eutectic mixture of local anesthetics (EMLA) cream in reducing pain during needle EMG examination. Design: A randomized controlled clinical trial. Setting: The Physical Medicine and Rehabilitation Department of a university hospital. Participants: In..Depression before and after cardiac surgery: Do all patients respond the same?
The Journal of Thoracic and Cardiovascular Surgery
Dec 2012
Depression before and after cardiac surgery: Do all patients respond the same?
Objective: To characterize the prevalence, incidence, and risk factors for depression before and after cardiac surgery. Methods: Patients awaiting nonemergent surgery (N = 436), completed the Patient Health Questionnaire-9 for depression, as well as the International Physical Activity Questionnaire short version..Determinants of renal function at hospital discharge of patients treated with renal replacement therapy in the intensive care unit
Journal of Critical Care
Dec 2012
Determinants of renal function at hospital discharge of patients treated with renal replacement therapy in the intensive care unit
Purpose: Identification of risk factors for impaired renal function at hospital discharge in critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT). Methods: A single-center retrospective cohort study was performed evaluating demographic and clinical parameters as potential..Efficacy of cranial electric stimulation for the treatment of insomnia: A randomized pilot study
Complementary Therapies in Medicine
Dec 2012
Efficacy of cranial electric stimulation for the treatment of insomnia: A randomized pilot study
Objectives: This pilot study examined the potential efficacy of cranial electric stimulation for the treatment of insomnia. Design: The researchers tested the hypothesis through a randomized, double-blind, and placebo controlled clinical trial. The researchers approached eligible subjects who scored 21 or above on the..Hypereosinophilic obliterative bronchiolitis: a distinct, unrecognised syndrome
European Respiratory Journal
Dec 2012
Hypereosinophilic obliterative bronchiolitis: a distinct, unrecognised syndrome
Background: Only isolated biopsy-proven cases of eosinophilic bronchiolitis have been reported, all from Japan. Methods: We present 6 patients with hypereosinophilic obliterative bronchiolitis (HOB), defined by the following criteria: 1-blood eosinophil cell count>1 G·L−1 and/or BAL eosinophil count>25%, 2-persistent..Hypophosphatemia in critically ill patients
Journal of Critical Care
Dec 2012
Hypophosphatemia in critically ill patients
Purpose: The aim of this study was to assess the association of phosphate concentration with key clinical outcomes in a heterogeneous cohort of critically ill patients. Materials and Methods: This was a retrospective observational study at a general intensive care unit (ICU) of an Australian university teaching..Improving the 2007 Infectious Disease Society of America/American Thoracic Society severe community-acquired pneumonia criteria to predict intensive care unit admission
Journal of Critical Care
Dec 2012
Improving the 2007 Infectious Disease Society of America/American Thoracic Society severe community-acquired pneumonia criteria to predict intensive care unit admission
Purpose: To improve 2007 Infectious Disease Society of America/American Thoracic Society (IDSA/ATS) severity criteria to predict intensive care unit (ICU) admission in patients hospitalized with pneumonia. Methods: A composite score that included the 2007 IDSA/ATS criteria for severe pneumonia and additional..Investigation of phthalate release from tracheal tubes
Anaesthesia
Dec 2012
Investigation of phthalate release from tracheal tubes
Phthalates are chemicals used extensively in the manufacture of plastics for their desirable physical characteristics. In addition to enhancing the performance of plastics, phthalates have a number of undesirable effects, principally endocrine disruptor effects, that may have adverse effects on reproductive development..Local and systemic cytokine profiles in non-severe and severe community-acquired pneumonia
European Respiratory Journal
Dec 2012
Local and systemic cytokine profiles in non-severe and severe community-acquired pneumonia
Local inflammatory responses in community-acquired pneumonia (CAP) remain insufficiently elucidated, especially in patients with non-severe CAP. In this study we determined local and systemic cytokine responses in CAP patients and correlated these with disease severity and other clinical parameters. Levels of..Nurse-driven, protocol-directed weaning from mechanical ventilation improves clinical outcomes and is well accepted by intensive care unit physicians
Journal of Critical Care
Dec 2012
Nurse-driven, protocol-directed weaning from mechanical ventilation improves clinical outcomes and is well accepted by intensive care unit physicians
Purpose: Ventilator weaning protocols can improve clinical outcomes, but their impact may vary depending on intensive care unit (ICU) structure, staffing, and acceptability by ICU physicians. This study was undertaken to examine their relationship. Design/Methods: We prospectively examined outcomes of 102 mechanically..Promoting Transplantation Tolerance; Adoptive Treg Cell Therapy
Clinical & Experimental Immunology
Dec 2012
Promoting Transplantation Tolerance; Adoptive Treg Cell Therapy
Transplantation is a successful treatment for end-stage organ failure. Despite improvements in short term outcome, long-term survival remains suboptimal because of the morbidity and mortality associated with long term use of immunosuppression. There is, therefore, a pressing need to devise protocols that induce..Satisfaction and problems experienced with transfemoral suspension systems: a comparison between common suction socket and Seal-In liner
Archives of Physical Medicine and Rehabilitation
Dec 2012
Satisfaction and problems experienced with transfemoral suspension systems: a comparison between common suction socket and Seal-In liner
Objective: To compare a seal-in liner with the common suction socket with regards to patient satisfaction and problems experienced with the prosthesis. Design: Retrospective survey. Setting: Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran and Department of Biomedical Engineering, Faculty of..The effect of inner tube placement on resistance and work of breathing through tracheostomy tubes: a bench test
Anaesthesia
Dec 2012
The effect of inner tube placement on resistance and work of breathing through tracheostomy tubes: a bench test
To reduce the risk of tracheostomy tube blockage, a removable inner tube can be used. However, this will reduce the size of the lumen and will increase airflow resistance and work of breathing. The magnitude of this increase in workload is unknown. We undertook a bench test to measure the effect. A lung model was..Tirone David valve-sparing aortic root replacement and cusp repair for bicuspid aortic valve disease
The Journal of Thoracic and Cardiovascular Surgery
Dec 2012
Tirone David valve-sparing aortic root replacement and cusp repair for bicuspid aortic valve disease
Objectives: The durability of valve-sparing aortic root replacement with or without cusp repair in patients with bicuspid aortic valve (BAV) disease is questioned. We analyzed the results of 75 patients with a BAV undergoing Tirone David reimplantation valve-sparing aortic root replacement. Methods: Average age was 45..ALK5 Inhibition Reverses Impairment of Endothelial Cell Viability by Endogenous Islet Mesenchymal Stromal Cells
Stem Cells
Dec 2012
ALK5 Inhibition Reverses Impairment of Endothelial Cell Viability by Endogenous Islet Mesenchymal Stromal Cells
Following islet transplantation, islet graft revascularization is compromised due to loss of endothelial cells (ECs) during islet culture. TGF-β signaling pathways are essential for vascular homeostasis but their importance for islet EC function is unclear. We have identified a population of multipotent mesenchymal..Automated liver stiffness measurements with magnetic resonance elastography
Journal of Magnetic Resonance Imaging
Dec 2012
Automated liver stiffness measurements with magnetic resonance elastography
Purpose: To provide a fully automated algorithm for obtaining stiffness measurements from hepatic magnetic resonance elastography (MRE) images that are consistent with measurements performed by expert readers. Materials and Methods: An initial liver contour was found using an adaptive threshold and expanded using an..Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM
Journal of Magnetic Resonance Imaging
Dec 2012
Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM
Purpose: To evaluate which common post-processing method applied to gradient-echo DSC-MRI data, acquired with a single gadolinium injection and low flip-angle, most accurately reflects microvascular histopathology for patients with de novo, treatment-naive glioblastoma multiforme (GBM). Materials and Methods:..Direct in vitro comparison of six three-dimensional positive contrast methods for susceptibility marker imaging
Journal of Magnetic Resonance Imaging
Dec 2012
Direct in vitro comparison of six three-dimensional positive contrast methods for susceptibility marker imaging
Purpose: To compare different techniques for positive contrast imaging of susceptibility markers with MRI for three-dimensional visualization. As several different techniques have been reported, the choice of the suitable method depends on its properties with regard to the amount of positive contrast and the desired..Epigenetic Regulation of Nanog by miR-302 cluster-MBD2 Completes iPS Cell Reprogramming
Stem Cells
Dec 2012
Epigenetic Regulation of Nanog by miR-302 cluster-MBD2 Completes iPS Cell Reprogramming
While most somatic cells undergoing iPS cell reprogramming with Yamanaka factors accumulate at stable partially reprogrammed stages, the molecular mechanisms required to achieve full reprogramming are unknown. MicroRNAs (miRNAs) fine-tune mRNA translation and are implicated in reprogramming, but miRNA functional..Gadoxetic acid-enhanced MRI with MR cholangiography for the preoperative evaluation of bile duct cancer
Journal of Magnetic Resonance Imaging
Dec 2012
Gadoxetic acid-enhanced MRI with MR cholangiography for the preoperative evaluation of bile duct cancer
Purpose: To assess the diagnostic accuracy of gadoxetic acid-enhanced biliary MRI with MR cholangiography (MRC) in the preoperative evaluation of bile duct cancer (BDC) staging and resectability. Materials and Methods: Seventy-three patients with BDC who underwent gadoxetic acid-enhanced biliary MRI and MRC, were..Induction of Pluripotent Stem Cells from Primordial Germ Cells by Single Reprogramming Factors
Stem Cells
Dec 2012
Induction of Pluripotent Stem Cells from Primordial Germ Cells by Single Reprogramming Factors
Germ cells are similar to pluripotent stem cells in terms of gene expression patterns and the capacity to convert to pluripotent stem cells in culture. The factors involved in germ cell development are also able to reprogram somatic cells. This suggests that germ cells are useful tools for investigating the mechanisms..One thousand genomes imputation in the national cancer institute breast and prostate cancer cohort consortium aggressive prostate cancer genome-wide association study
The Prostate
Dec 2012
One thousand genomes imputation in the national cancer institute breast and prostate cancer cohort consortium aggressive prostate cancer genome-wide association study
Background: Genotype imputation substantially increases available markers for analysis in genome-wide association studies (GWAS) by leveraging linkage disequilibrium from a reference panel. We sought to (i) investigate the performance of imputation from the August 2010 release of the 1000 Genomes Project (1000GP) in an..Prostate specific membrane antigen (PSMA): A novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells
The Prostate
Dec 2012
Prostate specific membrane antigen (PSMA): A novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells
Background: Regulated activation of p38 is crucial for cell proliferation, survival, and metabolism. Our previous studies had showed that prostate specific membrane antigen (PSMA) can facilitate the proliferation, migration, survival of the LNCaP prostate cancer cell line, but the mechanisms are poorly defined...Role of diffusion-weighted magnetic resonance imaging in the diagnosis of gallbladder cancer
Journal of Magnetic Resonance Imaging
Dec 2012
Role of diffusion-weighted magnetic resonance imaging in the diagnosis of gallbladder cancer
Purpose: To determine the additional diagnostic value of high b-value diffusion-weighted imaging (DWI) compared to conventional biliary magnetic resonance imaging (MRI) for differentiating gallbladder (GB) cancer from benign GB diseases with wall thickening. Materials and Methods: Thirty-nine patients with GB cancers..The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport
European Journal of Clinical Investigation
Dec 2012
The impact of gender and serum estradiol levels on HDL-mediated reverse cholesterol transport
Objective: Premenopausal women have a lower incidence of cardiovascular disease compared to men of the same age. Endogenous estrogens, especially estradiol, presumably protect against atherosclerosis by a variety of mechanisms. Reverse cholesterol transport (RCT) mechanisms also provide protection against this disease...A multicenter, randomized, controlled trial testing the effects of acupuncture on allergic rhinitis
Allergy
Dec 2012
A multicenter, randomized, controlled trial testing the effects of acupuncture on allergic rhinitis
Background: The aim of this study was to evaluate the efficacy and safety of acupuncture in the treatment for allergic rhinitis. Methods: This study was a multicenter, randomized, parallel-controlled study. Participants were randomized to either the active acupuncture, sham acupuncture, or waitlist groups. The active..Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models
Allergy
Dec 2012
Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models
Background: Allergy is an acquired hypersensitivity reaction of the immune system mediated by cross-linking of allergen-specific IgE-bound high-affinity IgE receptors, leading to immediate mast cell degranulation. Artesunate is a semi-synthetic derivative of artemisinin, an active component of the medicinal plant..Characteristics of anaphylaxis-inducing IgG immune complexes triggering murine passive systemic anaphylaxis
Allergy
Dec 2012
Characteristics of anaphylaxis-inducing IgG immune complexes triggering murine passive systemic anaphylaxis
Background: With the broad and increasing application of therapeutic monoclonal antibodies (mAbs) in clinical settings, IgG-induced allergic reactions, including passive systemic anaphylaxis (PSA), have attracted significant attention. However, it is not clear which types of IgG mAb–antigen complexes or IgG aggregates..Homeopathic treatment of premenstrual syndrome: a case series
Homeopathy
Dec 2012
Homeopathic treatment of premenstrual syndrome: a case series
Objective: Observational, prospective study to describe the homeopathic management of premenstrual syndrome (PMS) by a group of French physicians. Method: Women with PMS for >3 months were prescribed individualized homeopathic treatment. The intensity of 10 clinical symptoms of PMS was scored individually at inclusion..Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study
Allergy
Dec 2012
Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study
Background: Vitamin D levels are known to be associated with atopic disease development; however, existing data are controversial. The aim of this study was to investigate whether corresponding maternal and cord blood vitamin D levels are associated with atopic outcomes in early infancy. Methods: Within the LINA cohort..Mechanisms of peripheral tolerance to allergens
Allergy
Dec 2012
Mechanisms of peripheral tolerance to allergens
The immune system is regulated to protect the host from exaggerated stimulatory signals establishing a state of tolerance in healthy individuals. The disequilibrium in immune regulatory vs effector mechanisms results in allergic or autoimmune disorders in genetically predisposed subjects under certain environmental..Persistent undifferentiated arthritis successfully treated with the Japanese herbal medicine “Eppikajutsuto”
European Journal of Integrative Medicine
Dec 2012
Persistent undifferentiated arthritis successfully treated with the Japanese herbal medicine “Eppikajutsuto”
Objective: Undifferentiated arthritis (UA) is a rheumatic disease that is difficult to handle because there are still no standard guidelines for the treatment of patients with persistent UA. We encountered 3 patients with persistent UA successfully treated with the Japanese herbal (Kampo) medicine “Eppikajutsuto”...Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects
Homeopathy
Dec 2012
Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects
Key concepts of the Nanoparticle-Allostatic Cross-Adaptation-Sensitization (NPCAS) Model for the action of homeopathic remedies in living systems include source nanoparticles as low level environmental stressors, heterotypic hormesis, cross-adaptation, allostasis (stress response network), time-dependent sensitization..Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model
Allergy
Dec 2012
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model
Background: Sphingosine-1-phosphate (S1P) plays a crucial role in homeostasis of the immune system by regulating lymphocyte recirculation and inflammatory cell recruitment. The levels of S1P are tightly controlled through regulated production and controlled breakdown by sphingosine-lyase (SL). The S1P analogue FTY720..A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component
Anaesthesia
Dec 2012
A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component
Persistent mechanical irritation of the nerve root sets up a series of events mediating sensitisation of the dorsal roots and dorsal horns in the spinal cord. Current evidence supports the role of magnesium in blocking central sensitisation through its effect on N-methyl–d-aspartate receptors. We studied the role of..Clinical verification in homeopathy and allergic conditions
Homeopathy
Dec 2012
Clinical verification in homeopathy and allergic conditions
Background: The literature on clinical research in allergic conditions treated with homeopathy includes a meta-analysis of randomised controlled trials (RCT) for hay fever with positive conclusions and two positive RCTs in asthma. Cohort surveys using validated Quality of Life questionnaires have shown improvement in..Dynamized follicle-stimulating hormone affects the development of ovine preantral follicles cultured in vitro
Homeopathy
Dec 2012
Dynamized follicle-stimulating hormone affects the development of ovine preantral follicles cultured in vitro
Objective: To evaluate the effect of dynamized follicle-stimulating hormone (FSH) on the survival, activation and growth of ovine preantral follicles (PFs) in vitro. Methods: Ovarian fragments were cultured for 1 or 7 days in alpha minimum essential medium (α-MEM+) control in the absence or presence of alcohol (Al..Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress
Homeopathy
Dec 2012
Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress
Objective: To analyze the effect of homeopathic Arnica on mitochondrial oxidative stress induced by Ca2+ plus inorganic phosphate and/or Fe2+-citrate-mediated lipid peroxidation through changes in oxygen consumption rates. Methods: Mitochondria were isolated by differential centrifugation from the livers of adult male..H3N2 homeopathic influenza virus solution modifies cellular and biochemical aspects of MDCK and J774G8 cell lines
Homeopathy
Dec 2012
H3N2 homeopathic influenza virus solution modifies cellular and biochemical aspects of MDCK and J774G8 cell lines
Background: Influenza viruses cause highly contagious acute respiratory illnesses with significant mortality, especially among young children, elderly people, and individuals with serious medical conditions. This encourages the development of new treatments for human flu. Biotherapies are diluted solutions prepared..Human fetal sacrococcygeal extension or ‘tail’ in the second trimester: prenatal diagnosis, associated findings, and clinical outcome
Prenatal Diagnosis
Dec 2012
Human fetal sacrococcygeal extension or ‘tail’ in the second trimester: prenatal diagnosis, associated findings, and clinical outcome
Background: There are over 30 cases of prenatally diagnosed sacral extensions or human ‘tails’ in the literature, including isolated and syndromic etiologies. Most cases were reported to resolve by the second trimester and postnatal course was benign. Our objective was to describe the prenatal findings, associated..Effect of penehyclidine hydrochloride on the incidence of intra-operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia
Anaesthesia
Dec 2012
Effect of penehyclidine hydrochloride on the incidence of intra-operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia
Intra-operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double-blinded trial in 920 patients undergoing breast cancer surgery under bispectral index-guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on..Is Resternotomy a Risk for Continuous-Flow Left Ventricular Assist Device Outcomes?
Journal of Cardiac Surgery
Dec 2012
Is Resternotomy a Risk for Continuous-Flow Left Ventricular Assist Device Outcomes?
Background: The number of patients undergoing resternotomy continues to rise. Although catastrophic hemorrhage remains a dreaded complication, most published data suggest that sternal reentrance is safe, with negligible postoperative morbidity and mortality. A significant proportion of left ventricular assist device..Secular trends in weight, height and BMI in young Swedes: The ‘Grow up Gothenburg’ Studies
Acta Paediatrica
Dec 2012
Secular trends in weight, height and BMI in young Swedes: The ‘Grow up Gothenburg’ Studies
Aim: This study aims to document secular differences in anthropometry (level and variability of weight, height, BMI) in two cohorts born around 1990 and 1974 and examined as young adults. Methods: Descriptive results are presented for the complete cohorts. The final analysis age-matched the cohorts (mean, 18.8 years)..The Role of Computed Tomography Coronary Angiography in the Management of Coronary Anomalies
Journal of Cardiac Surgery
Dec 2012
The Role of Computed Tomography Coronary Angiography in the Management of Coronary Anomalies
Congenital abnormalities of coronary arteries are an uncommon cause of sudden cardiac death and are difficult to detect at coronary angiography. We describe two patients with acute coronary syndrome and non-occlusive coronary artery disease in which a 64-multidetector computed tomography (MDCT) coronary angiography..Left Main Coronary Atresia
Journal of Cardiac Surgery
Dec 2012
Left Main Coronary Atresia
Left main coronary artery atresia (LMCAA) is one of the least frequently observed congenital coronary anomalies. We describe a case series of LMCAA, highlighting the clinical presentation, characteristic, and treatment...Maternal Hypertensive Disorders during Pregnancy and Mild Cognitive Limitations in the Offspring
Paediatric and Perinatal Epidemiology
Dec 2012
Maternal Hypertensive Disorders during Pregnancy and Mild Cognitive Limitations in the Offspring
Background: It remains unclear whether maternal hypertensive disorders could impact cognitive development of the child. The aim of this study was to explore the association between hypertensive disorders and other maternal biological and social factors on the risk of mild cognitive limitations (intelligence quotient..α-Glucosidase and α-Amylase Inhibitory Activity of Senna surattensis
Journal of Acupuncture and Meridian Studies
Dec 2012
α-Glucosidase and α-Amylase Inhibitory Activity of Senna surattensis
In this study, we investigated the inhibitory effects of ethanolic extract of the leaves of Senna surattensis (EESS) on α-glucosidase and α-amylase. We also studied the in vitro antidiabetic activity of S. surattensis using the glucose uptake by isolated rat hemidiaphragm model. In vitro studies using mammalian..Follow-up study of 2-year-olds born at very low gestational age in Estonia
Acta Paediatrica
Dec 2012
Follow-up study of 2-year-olds born at very low gestational age in Estonia
Aim: To study very low gestational age (VLGA, <32 weeks) infants at 2 years of age and to identify the predictors of adverse outcomes. Methods: A population-based cohort of 155 surviving VLGA infants born in Estonia in 2007 was followed up and compared with a matched full-term (FT) control group. A logistic regression..Risk factors associated with the metabolic syndrome in abdominal obesity
Clinical Obesity
Dec 2012
Risk factors associated with the metabolic syndrome in abdominal obesity
Obesity is associated with the metabolic syndrome. However, not all obese individuals have cardiovascular risk factors (CVRF). It is not clear how many abdominally obese individuals are free of CVRF and what distinguishes them from the group of obese individuals with CVRF. In this study, we aimed to assess the..Use of heated humidified high-flow nasal cannula oxygen in neonates: a UK wide survey
Acta Paediatrica
Dec 2012
Use of heated humidified high-flow nasal cannula oxygen in neonates: a UK wide survey
Aim: Heated humidified high-flow nasal cannula (HHHFNC) oxygen is a relatively new form of respiratory support and is increasing in popularity despite lack of supportive evidence and amid safety concerns. We investigated the prevalence of its use in tertiary neonatal units in the UK. Method: Electronic survey. Results:..A Comparative Study of the Efficacy of Endovenous Laser Treatment of the Incompetent Great Saphenous Under General Anesthesia with External Air Cooling with and Without Tumescent Anesthesia
Dermatologic Surgery
Dec 2012
A Comparative Study of the Efficacy of Endovenous Laser Treatment of the Incompetent Great Saphenous Under General Anesthesia with External Air Cooling with and Without Tumescent Anesthesia
Background: This clinical study reports our experience with endovenous laser treatment (ELT) in which external air cooling is used without classic tumescent anesthesia. Methods: Two hundred thirty-two patients underwent ELT under general sedation. In group A (n = 192), ELT was performed with air cooling but without the..Banana Leaves As an Alternative Wound Dressing
Dermatologic Surgery
Dec 2012
Banana Leaves As an Alternative Wound Dressing
Background: There is a need for cheap and efficacious wound dressings in developing countries. Banana leaves have been described as an excellent, inexpensive, easily available dressing material in tropical countries. As a natural product, banana leaves are heavily contaminated with various pathogens that must be..Comparison of Effectiveness of Electrocautery and Cryotherapy in Partial Matrixectomy After Partial Nail Extraction in the Treatment of Ingrown Nails
Dermatologic Surgery
Dec 2012
Comparison of Effectiveness of Electrocautery and Cryotherapy in Partial Matrixectomy After Partial Nail Extraction in the Treatment of Ingrown Nails
Objective: To determine an effective mode of therapy of ingrown nail using two different methods. Methods: Patients with the diagnosis of stage 2 or 3 ingrown nails were included and divided into two groups. In the first group, partial matrixectomy was performed using electrocautery after partial nail extraction; in..Effect of erythropoietin on liver regeneration in an experimental model of partial hepatectomy
International Journal of Surgery
Dec 2012
Effect of erythropoietin on liver regeneration in an experimental model of partial hepatectomy
Background and Aim: The liver shows remarkable regeneration ability after damage or resection. The main stimulant for hepatic regeneration is resection. Erythropoietin (EPO), which was initially used for anemia therapy, is today known as a general tissue protector owing to its anti-inflammatory, anti-oxidant,..Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study
International Journal of Obstetric Anesthesia
Dec 2012
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study
Background: Most patients undergoing caesarean delivery with general anaesthesia require systemic opioid administration. Due to its rapid onset and long duration of action, intravenous methadone may make it suitable for analgesia after caesarean delivery. Intraoperative methadone combined with postoperative intravenous..Great Saphenous Vein Diameter at the Saphenofemoral Junction and Proximal Thigh as Parameters of Venous Disease Class
European Journal of Vascular and Endovascular Surgery
Dec 2012
Great Saphenous Vein Diameter at the Saphenofemoral Junction and Proximal Thigh as Parameters of Venous Disease Class
Background: Great saphenous vein (GSV) incompetence is involved in the majority of cases of varicose disease. Standardised pre-interventional assessment is required to analyse the relative merit of treatment modalities. We weighed GSV diameter measurement at the sapheno-femoral junction (SFJ) against measurement at the..Hepatic cytokine response can be modulated using the Kupffer cell blocker gadolinium chloride in obstructive jaundice
International Journal of Surgery
Dec 2012
Hepatic cytokine response can be modulated using the Kupffer cell blocker gadolinium chloride in obstructive jaundice
Introduction: Depletion of Kupffer cells by gadolinium chloride (GdCl3) reduces the systemic response during sepsis. The study aim was to investigate the effect of this depletion on hepatic proinflammatory cytokine response to portal endotoxaemia. Methods: Sixteen Wistar rats were randomised to receive either saline IV..Lengthening osteotomy of the calcaneus and flexor digitorum longus tendon transfer in flexible flatfoot deformity improves talo-1st metatarsal-Index, clinical outcome and pedographic parameter
Foot and Ankle Surgery
Dec 2012
Lengthening osteotomy of the calcaneus and flexor digitorum longus tendon transfer in flexible flatfoot deformity improves talo-1st metatarsal-Index, clinical outcome and pedographic parameter
Lengthening osteotomy of the calcaneus (LO) and flexor digitorum longus tendon (FDL) transfer to the navicular is one option for the treatment of flexible flatfoot deformity (FD). The aim of the study was to analyse the amount of correction and clinical outcome including pedographic assessment. In a prospective..Long-term critical issues in pediatric renal transplant recipients: a single-center experience
Transplant International
Dec 2012
Long-term critical issues in pediatric renal transplant recipients: a single-center experience
Data on long-term outcomes after pediatric renal transplantation (Tx) are still limited. We report on a 20-year single-center experience. Medical charts of all consecutive pediatric Tx performed between 1987 and 2007 were reviewed. Data of patients who had been transferred to adult units were extracted from the French..Nationwide Prospective Study of Outcomes after Elective Incisional Hernia Repair
Journal of the American College of Surgeons
Dec 2012
Nationwide Prospective Study of Outcomes after Elective Incisional Hernia Repair
Background: Incisional hernia repair is a frequent surgical procedure, but perioperative risk factors and outcomes have not been prospectively assessed in large-scale studies. The aim of this nationwide study was to analyze surgical risk factors for early and late outcomes after incisional hernia repair. Study Design:..The Effect of Pregnancy Intention on Maternal Prenatal Behaviours and Parent and Child Health: Results of an Irish Cohort Study
Paediatric and Perinatal Epidemiology
Dec 2012
The Effect of Pregnancy Intention on Maternal Prenatal Behaviours and Parent and Child Health: Results of an Irish Cohort Study
Background: Unintended pregnancy is associated with increased risk for adverse neonatal and early childhood outcomes spanning an array of indicators, but it remains unclear whether these risks hold independent of other biological, social and environmental risk factors. Methods: This study uses data from the first wave..Using Parent Questionnaires to Assess Neurodevelopment in Former Preterm Infants: A Validation Study
Paediatric and Perinatal Epidemiology
Dec 2012
Using Parent Questionnaires to Assess Neurodevelopment in Former Preterm Infants: A Validation Study
Background: Former preterm and very low birthweight infants require close neurodevelopmental surveillance after hospital discharge, but in-person professional testing is resource-intensive and inconvenient for families. A standardised developmental questionnaire completed by parents offers an alternative to in-person..Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study
Transplant International
Dec 2012
Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study
The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs..Effects of a cost-effective surgical workflow on cosmesis and patient's satisfaction in open thyroid surgery
International Journal of Surgery
Dec 2012
Effects of a cost-effective surgical workflow on cosmesis and patient's satisfaction in open thyroid surgery
Purpose: In thyroid surgery, minimally invasive procedures are thought to improve cosmesis and patient's satisfaction. However, studies using standardized tools are scarce, and results are controversial. Moreover, minimally invasive techniques raise the question of material costs in a context of health spending cuts...Kinetic Growth Rate after Portal Vein Embolization Predicts Posthepatectomy Outcomes: Toward Zero Liver-Related Mortality in Patients with Colorectal Liver Metastases and Small Future Liver Remnant
Journal of the American College of Surgeons
Dec 2012
Kinetic Growth Rate after Portal Vein Embolization Predicts Posthepatectomy Outcomes: Toward Zero Liver-Related Mortality in Patients with Colorectal Liver Metastases and Small Future Liver Remnant
Background: Standardized future liver remnant (sFLR) volume and degree of hypertrophy after portal vein embolization (PVE) have been recognized as important predictors of surgical outcomes after major liver resection. However, the regeneration rate of the FLR after PVE varies among individuals and its clinical..Laparo-endoscopic single-site (LESS) pyeloplasty for recurrent pelvic-uretero junction obstruction (PUJO)
Surgical Practice
Dec 2012
Laparo-endoscopic single-site (LESS) pyeloplasty for recurrent pelvic-uretero junction obstruction (PUJO)
Pelvic-uretero junction obstruction (PUJO) is most often a congenital problem, but it can present clinically at any time of life. After diagnosis of PUJO was confirmed anatomically with CT scan and functionally with isotope diuretic renography, surgical treatment should be offered when symptoms or complications..MicroRNAs in Kidney Disease: An Emerging Understanding
American Journal of Kidney Diseases
Dec 2012
MicroRNAs in Kidney Disease: An Emerging Understanding
MicroRNAs (miRNAs) are short noncoding RNA molecules that function by negatively regulating the expression of their target genes in a tightly controlled manner. Accumulating evidence, based in part on effects seen after miRNA overexpression and/or knockdown, points to the critical involvement of miRNAs in kidney..Removal of Dabigatran by Hemodialysis
American Journal of Kidney Diseases
Dec 2012
Removal of Dabigatran by Hemodialysis
Dabigatran is a newly available oral direct thrombin inhibitor approved for anticoagulation therapy to prevent strokes in patients with nonvalvular atrial fibrillation. Unlike warfarin, dabigatran's observed therapeutic window and minimal drug-to-drug interaction suggest that invasive laboratory testing and dose..Repair of large and giant incisional hernia with onlay mesh: Perspective of a tertiary care hospital of a developing country
International Journal of Surgery
Dec 2012
Repair of large and giant incisional hernia with onlay mesh: Perspective of a tertiary care hospital of a developing country
Purpose: Ventral incisional hernias, especially large and giant, carry significant post repair complications. This retrospective review is undertaken to determine the outcomes of large and giant incisional hernia repair as well as the risk factors of recurrence and surgical site infection at a tertiary care hospital in..Single Port Video-Assisted Thoracoscopic Lobectomy for Early Stage Non-Small Cell Lung Carcinoma
Surgical Practice
Dec 2012
Single Port Video-Assisted Thoracoscopic Lobectomy for Early Stage Non-Small Cell Lung Carcinoma
Single port or uniport video-assisted thoracic surgery (VATS) has been gaining popularity in simple thoracic surgical procedures such as sympathectomy, and pleural or lung biopsies. Only recently has a Spanish group reported the successful attempt in performing single port major lung resections, including lobectomy and..Effect of a High-Protein Diet on Kidney Function in Healthy Adults: Results From the OmniHeart Trial
American Journal of Kidney Diseases
Dec 2012
Effect of a High-Protein Diet on Kidney Function in Healthy Adults: Results From the OmniHeart Trial
Background: Consumption of a diet high in protein can cause glomerular hyperfiltration, a potentially maladaptive response, which may accelerate the progression of kidney disease. Study Design: An ancillary study of the OmniHeart trial, a randomized 3-period crossover feeding trial testing the effects of partial..Insertion of an intrathecal catheter following accidental dural puncture: a meta-analysis
International Journal of Obstetric Anesthesia
Dec 2012
Insertion of an intrathecal catheter following accidental dural puncture: a meta-analysis
Background: Inserting an intrathecal catheter after accidental dural puncture in parturients to prevent postdural puncture headache is becoming increasingly popular. We aimed to identify relevant published articles investigating this intervention and subject data to a meta-analysis. Methods: A systematic literature..Splenic abscesses at a tertiary medical center in northern Taiwan
Journal of Microbiology, Immunology and Infection
Dec 2012
Splenic abscesses at a tertiary medical center in northern Taiwan
Background/Purpose: Splenic abscesses are uncommon. This study aimed at assembling the demographics, clinical features, microbiologic etiologies, imaging, treatments, and outcomes of patients with splenic abscesses at a tertiary medical center in northern Taiwan. Methods: The diagnosis of splenic abscess was made..Biochemical and functional characterization of a recombinant monomeric Factor VIII-Fc fusion protein
Journal of Thrombosis and Haemostasis
Dec 2012
Biochemical and functional characterization of a recombinant monomeric Factor VIII-Fc fusion protein
Background: Hemophilia A results from a deficiency in FVIII activity. Current treatment regimens require frequent dosing owing to the short half-life of FVIII. A recombinant FVIII-Fc fusion protein (rFVIIIFc) was molecularly engineered to increase the half-life of FVIII, 1.5–2-fold in several preclinical animal models..Business Travelers' Risk Perception of Infectious Diseases: Where Are the Knowledge Gaps, and How Serious Are They?
Journal of Travel Medicine
Dec 2012
Business Travelers' Risk Perception of Infectious Diseases: Where Are the Knowledge Gaps, and How Serious Are They?
Background: Many studies have explored the risk perception of frequent business travelers (FBT) toward malaria. However, less is known about their knowledge of other infectious diseases. This study aimed to identify knowledge gaps by determining the risk perception of FBT toward 11 infectious diseases. Methods: Our..A Web-Based Application for Initial Screening of Living Kidney Donors: Development, Implementation and Evaluation
American Journal of Transplantation
Dec 2012
A Web-Based Application for Initial Screening of Living Kidney Donors: Development, Implementation and Evaluation
Most centers utilize phone or written surveys to screen candidates who self-refer to be living kidney donors. To increase efficiency and reduce resource utilization, we developed a web-based application to screen kidney donor candidates. The aim of this study was to evaluate the use of this web-based application...Are health professionals responsible for the shortage of organs from deceased donors in Malaysia?
Transplant International
Dec 2012
Are health professionals responsible for the shortage of organs from deceased donors in Malaysia?
The rate of organ donations from deceased donors in Malaysia is among the lowest in the world. This may be because of the passivity among health professionals in approaching families of potential donors. A questionnaire-based study was conducted amongst health professionals in two tertiary hospitals in Kuala Lumpur,..Association Between Abnormal Myocardial Fatty Acid Metabolism and Cardiac-Derived Death Among Patients Undergoing Hemodialysis: Results From a Cohort Study in Japan
American Journal of Kidney Diseases
Dec 2012
Association Between Abnormal Myocardial Fatty Acid Metabolism and Cardiac-Derived Death Among Patients Undergoing Hemodialysis: Results From a Cohort Study in Japan
Background: Detecting myocardial ischemia in hemodialysis patients is crucial given the high incidence of silent ischemia and the high cardiovascular mortality rates. Abnormal myocardial fatty acid metabolism as determined by imaging with 123I-labeled BMIPP (β-methyl iodophenyl-pentadecanoic acid) might be associated..Elderly infection in the community due to ST5/SCCmecII methicillin-resistant Staphylococcus aureus (the New York/Japan clone) in Japan: Panton–Valentine leukocidin-negative necrotizing pneumonia
Journal of Microbiology, Immunology and Infection
Dec 2012
Elderly infection in the community due to ST5/SCCmecII methicillin-resistant Staphylococcus aureus (the New York/Japan clone) in Japan: Panton–Valentine leukocidin-negative necrotizing pneumonia
An 89-year-old man suffered from and died of necrotizing pneumonia with rapid progression and cavity formation due to methicillin-resistant Staphylococcus aureus (MRSA). He was at no risk for hospital-acquired MRSA infection. His MRSA exhibited genotype ST5/spa2(t002)/agr2/SCCmecII/coagulaseII and was negative for..Epidemiology of cervico-facial pediatric lymphadenitis as a result of nontuberculous mycobacteria
International Journal of Mycobacteriology
Dec 2012
Epidemiology of cervico-facial pediatric lymphadenitis as a result of nontuberculous mycobacteria
Cervical lymphadenitis as a result of nontuberculous mycobacteria, otherwise known as scrofula, is a disease occurring almost exclusively in immunocompetent young children. The most frequent mycobacterial species responsible is Mycobacterium avium, but a large number of other species may also be involved. The..Evaluation of Hypomagnesemia: Lessons From Disorders of Tubular Transport
American Journal of Kidney Diseases
Dec 2012
Evaluation of Hypomagnesemia: Lessons From Disorders of Tubular Transport
Hypomagnesemia is a highly prevalent clinical condition affecting a large number of hospitalized patients. A decrease in systemic magnesium concentration may lead to impaired function of both neurologic and cardiovascular systems. The kidney has a pivotal role in magnesium handling by adjusting the urinary excretion of..External Inosculation as a Feature of Revascularization Occurs After Free Transplantation of Murine Liver Grafts
American Journal of Transplantation
Dec 2012
External Inosculation as a Feature of Revascularization Occurs After Free Transplantation of Murine Liver Grafts
The induction of angiogenesis is essential for successful engraftment of freely transplanted cells or cellular composites. How to augment angiogenesis to ensure an appropriate viability of the grafts is still under investigation. This study evaluated the proangiogenic capability of different syngeneic free liver..IgG4-Related Tubulointerstitial Nephritis With Plasma Cell–Rich Renal Arteritis
American Journal of Kidney Diseases
Dec 2012
IgG4-Related Tubulointerstitial Nephritis With Plasma Cell–Rich Renal Arteritis
Immunoglobulin G4 (IgG4)-related tubulointerstitial nephritis is a newly recognized clinicopathologic entity that may occur as an isolated renal lesion or as part of a multisystem disorder. It is characterized by plasma cell–rich interstitial nephritis with abundant IgG4-positive plasma cells and IgG-dominant..Induction of platelet aggregation following direct physical interaction with diesel exhaust particles
Journal of Thrombosis and Haemostasis
Dec 2012
Induction of platelet aggregation following direct physical interaction with diesel exhaust particles
Background: There is a proven link between exposure to traffic-derived particulate air pollution and the incidence of platelet-driven cardiovascular diseases. It is suggested that inhalation of small, nanosized particles increases cardiovascular risk via toxicological and inflammatory processes and translocation of..Intravenous immunoglobulin replacement therapy to prevent pulmonary infection in a patient with Good's syndrome
Journal of Microbiology, Immunology and Infection
Dec 2012
Intravenous immunoglobulin replacement therapy to prevent pulmonary infection in a patient with Good's syndrome
Good's syndrome is an acquired immunodeficiency state associated with thymoma and characterized by recurrent pulmonary infections. We describe a 67-year-old woman who presented with respiratory symptoms caused by concomitant disseminated cytomegalovirus infection and Pneumocystis jiroveci pneumonia 38 months after..Intraventricular antimicrobial therapy in postneurosurgical Gram-negative bacillary meningitis or ventriculitis: A hospital-based retrospective study
Journal of Microbiology, Immunology and Infection
Dec 2012
Intraventricular antimicrobial therapy in postneurosurgical Gram-negative bacillary meningitis or ventriculitis: A hospital-based retrospective study
Background: Postneurosurgical Gram-negative bacillary meningitis (GNBM) or ventriculitis is a serious issue. Intraventricular (IVT) therapy has been applied; however, its effectiveness remains controversial, and the adverse drug effects are considerable. Methods: The demographic data, treatment strategies, and clinical..Late-Onset Cytomegalovirus (CMV) in Lung Transplant Recipients: Can CMV Serostatus Guide the Duration of Prophylaxis?
American Journal of Transplantation
Dec 2012
Late-Onset Cytomegalovirus (CMV) in Lung Transplant Recipients: Can CMV Serostatus Guide the Duration of Prophylaxis?
Evidence supports the use of 12 months of cytomegalovirus prophylaxis in all at-risk lung transplants; whether cytomegalovirus serostatus can be used to further optimize this duration remains to be determined. The purpose of this retrospective study was to determine if cytomegalovirus serostatus of both donor and..Mild hypothermia during global cardiac ischemia opens a window of opportunity to develop heart donation after cardiac death
Transplant International
Dec 2012
Mild hypothermia during global cardiac ischemia opens a window of opportunity to develop heart donation after cardiac death
Although heart donation after cardiac death (DCD) could greatly improve graft availability, concerns regarding warm ischemic damage typically preclude transplantation. Improving tolerance to warm ischemia may thus open a window of opportunity for DCD hearts. We investigated the hypothesis that, compared with..Platelets express and release osteocalcin and co-localize in human calcified atherosclerotic plaques
Journal of Thrombosis and Haemostasis
Dec 2012
Platelets express and release osteocalcin and co-localize in human calcified atherosclerotic plaques
Background: Although vascular-calcification mechanisms are only partially understood, the role of circulating calcifying cells and non-collagenous bone matrix proteins in the bone-vascular axis is emerging. Despite that platelets represent a cellular interface between hemostasis, inflammation, and atherosclerosis and..Renal Cortical Infarction Following Treatment With Sumatriptan in a Kidney Allograft Recipient
American Journal of Kidney Diseases
Dec 2012
Renal Cortical Infarction Following Treatment With Sumatriptan in a Kidney Allograft Recipient
Renal cortical infarction is a rare cause of acute kidney injury that results from inadequate blood flow to the kidney, most commonly as a consequence of thrombotic or embolic occlusion of the renal artery or profound hypoperfusion. We report the case of a 78-year-old female kidney transplant recipient who developed a..Retinopathy and Cognitive Impairment in Adults With CKD
American Journal of Kidney Diseases
Dec 2012
Retinopathy and Cognitive Impairment in Adults With CKD
Background10:30 Retinal microvascular abnormalities have been associated with cognitive impairment, possibly serving as a marker of cerebral small-vessel disease. This relationship has not been evaluated in persons with chronic kidney disease (CKD), a condition associated with increased risk of both retinal pathology..The Effect of Everolimus Versus Mycophenolate Upon Proteinuria Following Kidney Transplant and Relationship to Graft Outcomes
American Journal of Transplantation
Dec 2012
The Effect of Everolimus Versus Mycophenolate Upon Proteinuria Following Kidney Transplant and Relationship to Graft Outcomes
Although mTOR inhibitor use has been associated with proteinuria in kidney transplant recipients, dose dependency and impact on allograft function are unknown. In a post hoc analysis, we compared rates of proteinuria 3 months posttransplant among everolimus (EVR) and mycophenolate (MPA) treatment arms and used a..Inactivation of enveloped and non-enveloped viruses in the process of chemical treatment and gamma irradiation of bovine-derived grafting materials
Xenotransplantation
Dec 2012
Inactivation of enveloped and non-enveloped viruses in the process of chemical treatment and gamma irradiation of bovine-derived grafting materials
Background: Xenografts, unlike other grafting products, cannot be commercialized unless they conform to stringent safety regulations. Particularly with bovine-derived materials, it is essential to remove viruses and inactivate infectious factors because of the possibility that raw materials are imbrued with infectious..Regional, institutional and individual factors affecting selection of minimally invasive nephroureterectomy in Japan: A national database analysis
International Journal of Urology
Dec 2012
Regional, institutional and individual factors affecting selection of minimally invasive nephroureterectomy in Japan: A national database analysis
Objectives: To reveal individual, institutional and regional factors affecting selection of minimally invasive nephroureterectomy in Japan. Methods: The Japanese Diagnosis Procedure Combination database was queried to retrieve cases of nephroureterectomy for pelvic or ureter malignancies carried out between 2007 and..Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+ and Ba2+
Xenotransplantation
Dec 2012
Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+ and Ba2+
Background: The main hurdles to the widespread use of islet transplantation for the treatment of type 1 diabetes continue to be the insufficient number of appropriate donors and the need for immunosuppression. Microencapsulation has been proposed as a means to protect transplanted islets from the host’s immune system...The role of belataceptin transplantation: results and implications of clinical trials in the context of other new biological immunosuppressant agents
Clinical Transplantation
Dec 2012
The role of belataceptin transplantation: results and implications of clinical trials in the context of other new biological immunosuppressant agents
Although conventional immunosuppressive agents such as calcineurin inhibitors, have substantially reduced the risk of acute rejection, they have had less impact on the long-term survival. This is likely to be related to the adverse effects of such agents in terms of impaired renal function, hypertension, and..Impact of donor age on long-term outcomes after delayed graft function: 10-year follow-up
Transplant International
Dec 2012
Impact of donor age on long-term outcomes after delayed graft function: 10-year follow-up
Delayed graft function (DGF) has a negative impact on graft survival in donation after brain death (DBD) but not for donation after cardiac death (DCD) kidneys. However, older donor age is associated with graft loss in DCD transplants. We sought to examine the interaction between donor age and DGF in DBD kidneys. This..Living organ donation practices in Europe – results from an online survey
Transplant International
Dec 2012
Living organ donation practices in Europe – results from an online survey
In Europe, living organ donation (LOD) is increasingly accepted as a valuable solution to overcome the organ shortage. However, considerable differences exist between European countries regarding frequency, practices and acceptance of donor–recipient relations. As a response, the Coordination Action project ‘Living..The impact of wait list body mass index changes on the outcome after liver transplantation
Transplant International
Dec 2012
The impact of wait list body mass index changes on the outcome after liver transplantation
Obesity is associated with poor health outcomes in the general population, but the evidence surrounding the effect of body mass index (BMI) on postliver transplantation survival is contradictory. The aim of this study was to assess the impact of wait list BMI and BMI changes on the outcomes after liver transplantation...The impact of wait list body mass index changes on the outcome after liver transplantation
Transplant International
Dec 2012
The impact of wait list body mass index changes on the outcome after liver transplantation
Obesity is associated with poor health outcomes in the general population, but the evidence surrounding the effect of body mass index (BMI) on postliver transplantation survival is contradictory. The aim of this study was to assess the impact of wait list BMI and BMI changes on the outcomes after liver transplantation...Adherence to miltefosine treatment for visceral leishmaniasis under routine conditions in Nepal
Tropical Medcine and International Health
Nov 2012
Adherence to miltefosine treatment for visceral leishmaniasis under routine conditions in Nepal
Objective To assess patient adherence to unsupervised single-drug miltefosine treatment for visceral leishmaniasis and to identify the factors influencing adherence. Methods This is a prospective cohort study of 171 patients with Visceral leishmaniasis (VL) in three healthcare settings in Nepal. Adherence was assessed..Adrenoceptor Function and Expression in Bladder Urothelium and Lamina Propria
Urology
Nov 2012
Adrenoceptor Function and Expression in Bladder Urothelium and Lamina Propria
Objective: To investigate the role of adrenoceptor subtypes in regulating the spontaneous contractile activity of the inner lining of the urinary bladder (urothelium/lamina propria). Materials and Methods: The responses of isolated strips of porcine urothelium/lamina propria to noradrenaline, phenylephrine, and..Biobreeding rat islets exhibit reduced anti-oxidative defense and N-acetyl cysteine treatment delays Type 1 diabetes
Journal of Endocrinology
Nov 2012
Biobreeding rat islets exhibit reduced anti-oxidative defense and N-acetyl cysteine treatment delays Type 1 diabetes
Islet-level oxidative stress has been proposed as a trigger for Type 1 diabetes (T1D) and release of cytokines by infiltrating immune cells further elevates reactive oxygen species (ROS), exacerbating beta cell duress. To identify genes/mechanisms involved with diabetogenesis at the beta cell level, gene expression..Body mass index and its effect on outcome in children after lung transplantation
The Journal of Heart and Lung Transplantation
Nov 2012
Body mass index and its effect on outcome in children after lung transplantation
Background: Malnutrition is common in children undergoing lung transplantation, particularly among those with cystic fibrosis (CF). However, the effect of body habitus on outcome after pediatric lung transplantation is unknown. We studied body mass index (BMI) and its effect on outcome in pediatric lung..Determinants of Urolithiasis in Patients With Intestinal Fat Malabsorption
Urology
Nov 2012
Determinants of Urolithiasis in Patients With Intestinal Fat Malabsorption
Objective: To investigate the determinants of urinary stone formation in patients with fat malabsorption, because, although the prevalence of urolithiasis is greater in patients with intestinal diseases, the pathogenetic mechanisms and risk factors associated with urolithiasis in this population remain partially..Effect of Tamsulosin on Bladder Microcirculation in Rat Model of Bladder Outlet Obstruction Using Pencil Lens Charge-coupled Device Microscopy System
Urology
Nov 2012
Effect of Tamsulosin on Bladder Microcirculation in Rat Model of Bladder Outlet Obstruction Using Pencil Lens Charge-coupled Device Microscopy System
Objective: To determine the effect of tamsulosin hydrochloride on blood flow in the submucosal capillaries of the bladder (SCB) in a rat model of bladder outlet obstruction (BOO) using a pencil lens charge-coupled device microscopy system. Materials and Methods: BOO was established in rats by partial ligature of the..Is Urinary Kidney Injury Molecule-1 a Noninvasive Marker for Renal Scarring in Children With Vesicoureteral Reflux?
Urology
Nov 2012
Is Urinary Kidney Injury Molecule-1 a Noninvasive Marker for Renal Scarring in Children With Vesicoureteral Reflux?
Objective: To examine whether (1) levels of urinary kidney injury molecule-1 (KIM-1), a transmembrane protein and biomarker for renal tubular damage, increase in children with of vesicoureteral reflux (VUR), and (2) if KIM-1 predicts the grade of renal scarring in children with VUR. Methods: The study included 59 VUR..Molecular surveillance and clinical outcomes of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae infections
Journal of Microbiology, Immunology and Infection
Nov 2012
Molecular surveillance and clinical outcomes of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae infections
Background/Purpose: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) is a cause for great concern. The aim of this study was to evaluate antimicrobial susceptibility, mechanisms of carbapenem-resistance in two members of the Enterobacteriaceae family (Escherichia coli and Klebsiella pneumoniae), and..Nature and Fate of Supranormal Differential Renal Function: Lessons From Long-term Follow-up After Pyeloplasty
Urology
Nov 2012
Nature and Fate of Supranormal Differential Renal Function: Lessons From Long-term Follow-up After Pyeloplasty
Objective: To understand the nature and long-term fate of supranormal differential renal function (snDRF), analysis of a post-pyeloplasty database was performed. Materials and Methods: Preoperative diethylenetriaminepentaacetic acid (DTPA) diuretic renal scans (DRS) identified 33 children with snDRF (>55%)...Needles as Urethral Foreign Body in a Child: Successful Removal Using a New Method With a Laparoscopic Needle Holder
Urology
Nov 2012
Needles as Urethral Foreign Body in a Child: Successful Removal Using a New Method With a Laparoscopic Needle Holder
Self-inserted foreign bodies in the lower urinary tract are rare among children. The treatment of foreign bodies in the urethra is determined by their type, size, location, shape, and mobility. We describe here a 13-year-old boy who had self-inserted a needle into his urethra out of curiosity. Initial attempts to..Preliminary studies developing methods for the control of Chrysomya putoria, the African latrine fly, in pit latrines in The Gambia
Tropical Medcine and International Health
Nov 2012
Preliminary studies developing methods for the control of Chrysomya putoria, the African latrine fly, in pit latrines in The Gambia
Objective: To explore ways of controlling Chrysomya putoria, the African latrine fly, in pit latrines. As pit latrines are a major source of these flies, eliminating these important breeding sites is likely to reduce village fly populations, and may reduce the spread of diarrhoeal pathogens. Methods: We treated 24..Prevalence and aetiology of juvenile skeletal fluorosis in the south-west of the Hai district, Tanzania – a community-based prevalence and case–control study
Tropical Medcine and International Health
Nov 2012
Prevalence and aetiology of juvenile skeletal fluorosis in the south-west of the Hai district, Tanzania – a community-based prevalence and case–control study
Introduction: Fluorosis is endemic throughout the East African Rift valley, including parts of Tanzania. The aim of the study was to identify all cases of deforming juvenile skeletal fluorosis (JSF) in a northern Tanzanian village and to document the extent of dental fluorosis (DF). Methods: Door-to-door prevalence..Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Leukemia Research
Nov 2012
Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Flow cytometry based minimal residual disease (MRD) was evaluated for outcome prediction in childhood acute myeloid leukemia (AML). The median levels of MRD in relapsed and nonrelapsed patients were different after the first induction (0.64% vs. 0.18%, P=0.030). A cutoff level of ≥0.25% after the first course of..Randomized Clinical Trial Comparing Effectiveness of Intracorpus Spongiosum Block Versus Topical Anesthesia for Performing Visual Internal Urethrotomy for Urethral Stricture Disease
Urology
Nov 2012
Randomized Clinical Trial Comparing Effectiveness of Intracorpus Spongiosum Block Versus Topical Anesthesia for Performing Visual Internal Urethrotomy for Urethral Stricture Disease
Objective: To compare the efficacy and safety of intracorpus spongiosum block (ICSB) over topical anesthesia for performing visual internal urethrotomy (VIU) in a randomized clinical trial. Methods: VIU for urethral stricture can be performed under various types of anesthesia, including topical anesthesia. Although..Stage of change and motivation to healthier lifestyle in nonalcoholic fatty liver disease
Journal of Hepatology
Nov 2012
Stage of change and motivation to healthier lifestyle in nonalcoholic fatty liver disease
Backgrounds & aims: Healthy diet and physical activity are the treatment cornerstones of nonalcoholic fatty liver disease (NAFLD); their effectiveness is however limited by difficulties in implementing lifestyle changes. We aimed to determine the stage of change and associated psychological factors as a prerequisite to..Symptomatic Bilateral Delayed Partial Ureteral Obstruction After Bilateral Endoscopic Correction of Vesicoureteral Reflux With Dextranomer/Hyaluronic Acid Polymer
Urology
Nov 2012
Symptomatic Bilateral Delayed Partial Ureteral Obstruction After Bilateral Endoscopic Correction of Vesicoureteral Reflux With Dextranomer/Hyaluronic Acid Polymer
Endoscopic correction of vesicoureteral reflux using dextranomer/hyaluronic acid copolymer (Deflux) is a widely used technique. Complications are uncommon, and ureteral obstruction occurs particularly infrequently. We present a case of delayed symptomatic partial bilateral ureteral obstruction after bilateral..The Mononuclear Phagocyte System in Kidney Disease and Repair
Nephrology
Nov 2012
The Mononuclear Phagocyte System in Kidney Disease and Repair
The mononuclear phagocyte system is comprised of circulating monocytes, tissue macrophages and dendritic cells (DCs) that play key roles in tissue homeostasis, immune surveillance, and immune and non-immune-mediated tissue injury and repair. This review summarises the various subsets within this system that exhibit..Transvaginal Mesh Kits—How “Serious” Are the Complications and Are They Reversible?
Urology
Nov 2012
Transvaginal Mesh Kits—How “Serious” Are the Complications and Are They Reversible?
Objective: To review the merit of the U.S. Food and Drug Administration-issued warnings on the use of transvaginal mesh in women with pelvic organ prolapse because of escalating complications. Materials and Methods: On institutional review board approval, we reviewed the data from 2 tertiary institutions managing..Tuberculosis and the risk of opportunistic infections and cancers in HIV-infected patients starting ART in Southern Africa
Tropical Medcine and International Health
Nov 2012
Tuberculosis and the risk of opportunistic infections and cancers in HIV-infected patients starting ART in Southern Africa
Objectives: To investigate the incidence of selected opportunistic infections (OIs) and cancers and the role of a history of tuberculosis (TB) as a risk factor for developing these conditions in HIV-infected patients starting antiretroviral treatment (ART) in Southern Africa. Methods: Five ART programmes from Zimbabwe,..Vaginal Symptoms and Sexual Function After Tension-free Vaginal Tape-obturator Placement: Minimum 12-Month Follow-up
Urology
Nov 2012
Vaginal Symptoms and Sexual Function After Tension-free Vaginal Tape-obturator Placement: Minimum 12-Month Follow-up
Objective: To examine the effect of the tension-free vaginal tape-obturator (TVT-O) on sexual function and vaginal symptoms. The effect of anti-incontinence surgery on vaginal symptoms and sexual function is controversial; these assessments are increasingly important given the Food and Drug Administration warning..Association between Sex Hormones and Colorectal Cancer Risk in Men and Women
Clinical Gastroenterology and Hepatology
Nov 2012
Association between Sex Hormones and Colorectal Cancer Risk in Men and Women
Background & Aims: There is observational and clinical evidence that indicate that sex hormones affect development of colorectal cancer (CRC) in men and women. However, the relationship between endogenous sex hormone levels and CRC is unclear. Methods: We collected data on lifestyle, medical history, and diet etc...Autologous and allogeneic transplantation for burkitt lymphoma outcomes and changes in utilization: a report from the center for international blood and marrow transplant research
Biology of Blood and Marrow Transplantation
Nov 2012
Autologous and allogeneic transplantation for burkitt lymphoma outcomes and changes in utilization: a report from the center for international blood and marrow transplant research
Trends in utilization and outcomes after autologous or allogeneic hematopoietic cell transplantation (HCT) for Burkitt Lymphoma (BL) were analyzed in 241 recipients reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) between 1985 and 2007. The autologous HCT cohort had a higher..Can Renal Nutrition Education Improve Adherence to a Low-Protein Diet in Patients With Stages 3 to 5 Chronic Kidney Disease?
Journal of Renal Nutrition
Nov 2012
Can Renal Nutrition Education Improve Adherence to a Low-Protein Diet in Patients With Stages 3 to 5 Chronic Kidney Disease?
Objective: Low adherence is frequently observed in patients with chronic kidney disease (CKD) who are following a low-protein diet. We have evaluated whether a specific nutrition education program motivates patients with CKD who do not yet receive dialysis to reduce their protein intake and whether such a program..Folinic acid supplementation in higher doses is associated with graft rejection in pediatric hematopoietic stem cell transplantation
Biology of Blood and Marrow Transplantation
Nov 2012
Folinic acid supplementation in higher doses is associated with graft rejection in pediatric hematopoietic stem cell transplantation
Folinic acid is widely used in hematopoietic stem cell transplantation (SCT), mainly to reverse antifolate effects of such drugs as methotrexate and cotrimoxazole, but also empirically to reduce toxicity and support hematopoietic recovery. However, concerns have been raised in oncohematology about reduced curative..Hepatitis B-core Antibody Positive Donors in Liver Transplantation and Their Impact on Graft Survival: Evidence From The Liver Match Cohort Study
Journal of Hepatology
Nov 2012
Hepatitis B-core Antibody Positive Donors in Liver Transplantation and Their Impact on Graft Survival: Evidence From The Liver Match Cohort Study
Background: The appropriate allocation of grafts from HBcAb positive donors in liver transplantation is crucial; yet a consensus is still lacking. Methods: We evaluated this issue within Liver Match; a prospective observational Italian study. Data from 1437 consecutive; first transplants performed in 2007-2009 using..Insulin Resistance and Protein Metabolism in Chronic Hemodialysis Patients
Journal of Renal Nutrition
Nov 2012
Insulin Resistance and Protein Metabolism in Chronic Hemodialysis Patients
Objective: Loss of lean body mass (sarcopenia) is associated with increased morbidity and mortality in patients receiving chronic hemodialysis (CHD). Insulin resistance (IR), which is highly prevalent in patients receiving CHD, has been proposed to play a critical role in the development of sarcopenia. The aim of this..Long-term results for living donor liver transplant recipients with hepatocellular carcinoma using intraoperative blood salvage with leukocyte depletion filter
Transplant International
Nov 2012
Long-term results for living donor liver transplant recipients with hepatocellular carcinoma using intraoperative blood salvage with leukocyte depletion filter
Massive intraoperative bleeding during liver transplantation often requires large amounts of blood products. The goal of this study was to investigate long-term outcomes of living donor liver transplantation (LDLT) recipients with hepatocellular carcinoma (HCC) who underwent intraoperative use of intraoperative blood..Measures of general and central obesity and risk of type 2 diabetes in a Ghanaian population
Tropical Medcine and International Health
Nov 2012
Measures of general and central obesity and risk of type 2 diabetes in a Ghanaian population
Objective: The epidemic of obesity and type 2 diabetes is evident in sub-Saharan Africa (SSA). However, their associations have hardly been examined in this region. Methods: A hospital-based case–control study in urban Ghana consisting of 1221 adults (542 cases and 679 controls) investigated the role of anthropometric..Model for end-stage liver disease-sodium and survival benefit in liver transplantation
Transplant International
Nov 2012
Model for end-stage liver disease-sodium and survival benefit in liver transplantation
There are currently no studies calculating the survival benefit of liver transplantation (LT) according to model for end-stage liver disease-sodium (MELD-Na) and based on the competing risk (CR) method. We enrolled consecutive adult patients with chronic end-stage liver disease entering the waiting list (WL) for..Mutant TP53 in Duodenal Samples of Pancreatic Juice from Patients with Pancreatic Cancer or High-Grade Dysplasia
Clinical Gastroenterology and Hepatology
Nov 2012
Mutant TP53 in Duodenal Samples of Pancreatic Juice from Patients with Pancreatic Cancer or High-Grade Dysplasia
Background & Aims: Imaging tests can identify patients with pancreatic neoplastic cysts but not microscopic dysplasia. We investigated wither mutant TP53 can be detected in duodenal samples of secretin-stimulated pancreatic juice, and whether this assay can be used to screen for high-grade dysplasia and invasive..Outcome of allogeneic peripheral blood stem cell transplantation by donor graft CD3+/Tregs ratio: a single centre experience
Biology of Blood and Marrow Transplantation
Nov 2012
Outcome of allogeneic peripheral blood stem cell transplantation by donor graft CD3+/Tregs ratio: a single centre experience
The therapeutic efficacy of allogeneic peripheral blood stem cell transplantation (PBSCT) for hematological malignancies relies largely on the graft-versus-leukemia (GVL) effects exerted by the donor CD3 cells, but there is a risk of onset of uncontrolled graft-versus-host disease (GVHD). T regs cells (CD4+CD25high..Placental Transfer of Anti-Tumor Necrosis Factor Agents in Pregnant Patients with Inflammatory Bowel Disease
Clinical Gastroenterology and Hepatology
Nov 2012
Placental Transfer of Anti-Tumor Necrosis Factor Agents in Pregnant Patients with Inflammatory Bowel Disease
Background & Aims: Some women with inflammatory bowel disease (IBD) require therapy with tumor necrosis factor (TNF) antagonists during pregnancy. It is not clear whether these drugs are transferred to the fetus, via the placenta, and then cleared, or whether structurally different TNF antagonists have different rates..Prognostic interest to discriminate muscularis mucosae invasion (T1a vs. T1b) in non-muscle-invasive bladder carcinomas: results from a French national multicentre study with a central pathology review
Journal of Urology
Nov 2012
Prognostic interest to discriminate muscularis mucosae invasion (T1a vs. T1b) in non-muscle-invasive bladder carcinomas: results from a French national multicentre study with a central pathology review
Purpose: Predictive factors of T1 non-muscle-invasive bladder cancer (NMIBC) evolution that could guide treatment decision making are lacking. Our aim was to assess the prognostic value of Muscularis mucosae (MM) invasion in NMIBC. Materials and methods: A national multicentric study recruited patients with primary T1..Proton Pump Inhibitors Reduce the Risk of Neoplastic Progression in Patients with Barrett’s Esophagus
Clinical Gastroenterology and Hepatology
Nov 2012
Proton Pump Inhibitors Reduce the Risk of Neoplastic Progression in Patients with Barrett’s Esophagus
Background & Aims: Acid exposure contributes to the development of Barrett's esophagus (BE) and its progression toward esophageal adenocarcinoma. Patients with BE are frequently treated with acid suppressants, but it is unclear whether these prevent the development of BE-related cancer. We investigated therefore..Role of microsatellite instability in the management of colorectal cancers
Digestive and Liver Disease
Nov 2012
Role of microsatellite instability in the management of colorectal cancers
Microsatellite instability is the consequence of a deficient mismatch repair system. It has a key role in the diagnostic strategy of Lynch syndrome, where tumours are all characterized by the presence of this phenotype. Microsatellite instability is therefore essential in the selection of colorectal cancer patients in..Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan
Journal of Clinical Virology
Nov 2012
Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan
Background: Every year, an estimated 200–500 children in Japan develop influenza-associated encephalopathy (IAE), and 10–30% of these children die. Objective: To clarify the clinical features of a severe form of acute encephalopathy seen with 2009 pandemic influenza A (H1N1). Study design: This retrospective survey..Socioeconomic burden of lymphatic filariasis in Georgetown, Guyana
Tropical Medcine and International Health
Nov 2012
Socioeconomic burden of lymphatic filariasis in Georgetown, Guyana
Objective: To assess the socioeconomic impact of lymphatic filariasis (LF) in Guyana. Methods: Observational, cross-sectional study of 50 persons with chronic LF attending the Filariasis Clinic who were selected as the cases; and 50 persons with chronic skin conditions but no chronic LF, attending the Skin Clinic who..Surgically-induced chronic kidney disease may be associated with lesser risk of progression and mortality than medical chronic kidney disease
Journal of Urology
Nov 2012
Surgically-induced chronic kidney disease may be associated with lesser risk of progression and mortality than medical chronic kidney disease
Purpose: CKD from medical causes (CKD-M) is present in 25-30% prior to surgery for renal cancer. Although CKD-M is typically associated with 2-5% annual renal functional decline (RFD) and reduced overall survival, reduced GFR occurring only after surgery (CKD-S) may not have the same negative consequences. Methods: All..Temporary intraoperative porto-caval shunt: useless or beneficial in piggy back liver transplantation?
Transplant International
Nov 2012
Temporary intraoperative porto-caval shunt: useless or beneficial in piggy back liver transplantation?
The role of intraoperative porto-caval shunts in orthotopic liver transplantation (OLT) is controversial. Aim of this study was to analyze the effects of an intraoperative, porto-caval catheter-shunt on graft function and survival following cava sparing OLT. Four hundred and forty-eight piggy back liver..The effects of calcineurin inhibitors on prostanoid synthesis: a randomized cross-over study in healthy humans
Transplant International
Nov 2012
The effects of calcineurin inhibitors on prostanoid synthesis: a randomized cross-over study in healthy humans
The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus (Tac) are implicated in post-transplant complications such as cardiovascular morbidity. Prostanoids are fatty acid-derived compounds essential for controlling cardiovascular homeostasis. We tested the hypothesis that CNIs suppress cyclooxygenase..The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival
Xenotransplantation
Nov 2012
The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival
Background: Various groups have reported prolonged diabetes reversal and graft function after porcine islet transplantation into diabetic macaques using different experimental designs (macaque source, islet source, type of immunosuppression): subsequently, the International Xenotransplantation Association has published..Urge perception index: a quantitative measure of bladder hyper-sensitivity in analysis of a bladder diary with a self-reported grading of urinary perception
Journal of Urology
Nov 2012
Urge perception index: a quantitative measure of bladder hyper-sensitivity in analysis of a bladder diary with a self-reported grading of urinary perception
Purpose: In analysis of a bladder diary with the patient’s self-reported urinary perception grades, we developed a quantitative measure of bladder hypersensitivity, which we refer to as the urge perception index (UPI). The aim of this study was to evaluate the impact of the UPI on defining the severity of overactive..A monoclonal expansion of Epstein–Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation
Journal of Clinical Virology
Nov 2012
A monoclonal expansion of Epstein–Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation
Here, we describe a Japanese woman showing a monoclonal expansion of EBV-infected natural killer (NK) cells after receiving allogeneic peripheral blood stem cell transplantation (PBSCT). The patient initially had T-cell-type chronic active EBV disease (CAEBV) and subsequently developed liver T-cell lymphoma...Androgen receptor expression relationship with semen variables in infertile men with varicocele
Journal of Urology
Nov 2012
Androgen receptor expression relationship with semen variables in infertile men with varicocele
Background: Androgen receptor (AR), a member of the nuclear receptor superfamily, plays important roles in male reproductive functions being required for sexual differentiation, pubertal development, regulation of spermatogenesis, completion of meiosis and transition of spermatocytes to haploid round spermatids...Anti-TNF-alpha treatments and obstructive symptoms in Crohn's Disease: A prospective study
Digestive and Liver Disease
Nov 2012
Anti-TNF-alpha treatments and obstructive symptoms in Crohn's Disease: A prospective study
Background: The development of symptomatic strictures in Crohn's Disease after anti-Tumour Necrosis Factor-α antibodies is undefined. Aim: To assess, in a prospective longitudinal study, the frequency of sub/obstructions in Crohn's Disease patients after treatment with Infliximab or Adalimumab. Changes of small bowel..Assisted reproductive techniques and the risk of the exstrophy-epispadias complex: a German case-control study
Journal of Urology
Nov 2012
Assisted reproductive techniques and the risk of the exstrophy-epispadias complex: a German case-control study
Purpose: To assess the risk for the exstrophy-epispadias-complex (EEC) following treatment for infertility with in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), two assisted reproductive techniques (ART). Materials and methods: Data of the German Network for Congenital Uro-REctal malformations..Circumcision and Lifetime Risk of Urinary Tract Infection: A Systematic Review and Meta-analysis
Journal of Urology
Nov 2012
Circumcision and Lifetime Risk of Urinary Tract Infection: A Systematic Review and Meta-analysis
Purpose: Urinary tract infection (UTI) is common in infant males who are uncircumcised and can lead to renal parenchymal disease of the still-growing pediatric kidney. Although the rate of UTI is highest in the first year of life, the cumulative incidence over the rest of the lifetime is under-recognized, but is..Cluster of leptospirosis cases among military personnel in Rio de Janeiro, Brazil
International Journal of Infectious Diseases
Nov 2012
Cluster of leptospirosis cases among military personnel in Rio de Janeiro, Brazil
We report two cases of leptospirosis in military personnel in southeastern Brazil. The cases were hospitalized following field training exercises, and presented with acute meningoencephalitis, respiratory illnesses, and skin rash. Leptospira interrogans serovars icterohaemorrhagiae, hebdomadis, patoc, and cynopteri..Combinations of urinary biomarkers for surveillance of patients with incident non-muscle invasive bladder cancer: The European FP7 UROMOL Project
Journal of Urology
Nov 2012
Combinations of urinary biomarkers for surveillance of patients with incident non-muscle invasive bladder cancer: The European FP7 UROMOL Project
Purpose: To determine a combination of markers with optimal sensitivity for detection of recurrences in voided urine after resection of an incident low-grade non-muscle invasive bladder tumor (NMIBC). Materials and methods: Patients with NMIBC G1/G2 (n=136) were included at trans-urethral resection of the incident..Duration of colonization and risk factors for prolonged carriage of vancomycin-resistant enterococci after discharge from the hospital
International Journal of Infectious Diseases
Nov 2012
Duration of colonization and risk factors for prolonged carriage of vancomycin-resistant enterococci after discharge from the hospital
Background: There are no available studies on the duration and risk factors of vancomycin-resistant enterococci (VRE) carriage after hospital discharge. In this study we investigated the duration of colonization with VRE and the risk factors for prolonged carriage in the outpatient clinic after discharge from the..Extracorporeal shock wave lithotripsy is effective in treating single melamine-induced urolithiasis in infants and young children
Journal of Urology
Nov 2012
Extracorporeal shock wave lithotripsy is effective in treating single melamine-induced urolithiasis in infants and young children
Purpose: To evaluate the efficacy of extracorporeal shock wave lithotripsy (ESWL) in treating infant melamine-induced single urolithiasis. Materials and Methods: Between March 2009 and July 2010, 189 infants and young children with single melamine-induced urolithiasis were referred to our center for treatment by ESWL...Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection
Journal of Hepatology
Nov 2012
Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection
Background & Aims: In the last decade pegylated interferon-α (Peg-INF-α) plus ribavirin (RBV) was the standard treatment of chronic hepatitis C for genotype 1, and it remains the standard for genotypes 2 and 3. Recent studies reported associations between RBV-induced anemia and genetic polymorphisms of concentrative..In Vitro Study of the Revised Ultrasound Based Real-Time Tracking of Renal Stones for Shock Wave Lithotripsy: Part 1
Journal of Urology
Nov 2012
In Vitro Study of the Revised Ultrasound Based Real-Time Tracking of Renal Stones for Shock Wave Lithotripsy: Part 1
Purpose: Extracorporeal Shock Wave Lithotripsy has been popular since 1980s. Of all the conventional lithotriptors, only 30% to 50% of shock waves are focused on stones. We developed an ultrasound based real-time stone tracking system (1st version) to improve accuracy and treatment efficiency. Yet, some problems..Infections of cerebrospinal fluid diversion devices in adults: The role of intraventricular antimicrobial therapy
Journal of Infection
Nov 2012
Infections of cerebrospinal fluid diversion devices in adults: The role of intraventricular antimicrobial therapy
Objectives: The precise role for intraventricular (IVT) antimicrobials in combination with systemic antibiotics in management of cerebrospinal fluid (CSF) diversion device-associated infections is uncertain. We evaluated our current practice, comparing dual therapy against systemic antimicrobials alone. Methods: All..Is the appearance of the Deflux Mound predictive of Reflux Resolution?
Journal of Urology
Nov 2012
Is the appearance of the Deflux Mound predictive of Reflux Resolution?
Purpose: To correlate the appearance of the Deflux mound after endoscopic correction of vesicoureteral reflux with the outcome. Material and Methods: We created an online survey based on 11 primary vesicoureteral reflux(VUR) cases (15 renal units, 6 failed and 9 successful procedures). Cases were selected randomly from..Mycobacterium tuberculosis genotype Beijing: About 15 strains and their part in MDR-TB outbreaks in Algeria
International Journal of Mycobacteriology
Nov 2012
Mycobacterium tuberculosis genotype Beijing: About 15 strains and their part in MDR-TB outbreaks in Algeria
Within the framework of epidemiological surveillance by molecular typing tools conducted in the NRL on multi-resistant strains, the application of spoligotyping on a group of 390 strains consisting of 389 DR-MTB strains and 1 susceptible strain isolated from patients made it possible to detect the presence of 15..Mycobacterium tuberculosis genotype Beijing: About 15 strains and their part in MDR-TB outbreaks in Algeria
International Journal of Mycobacteriology
Nov 2012
Mycobacterium tuberculosis genotype Beijing: About 15 strains and their part in MDR-TB outbreaks in Algeria
Within the framework of epidemiological surveillance by molecular typing tools conducted in the NRL on multi-resistant strains, the application of spoligotyping on a group of 390 strains consisting of 389 DR-MTB strains and 1 susceptible strain isolated from patients made it possible to detect the presence of 15..Natural History of Asymptomatic Renal Stones and Prediction of Stone-related Events
Journal of Urology
Nov 2012
Natural History of Asymptomatic Renal Stones and Prediction of Stone-related Events
Purpose: The appropriate management for asymptomatic renal stones remains unclear. The natural history and progression rate of such stones were assessed. Clinical factors associated with an increased risk of stone-related events were identified. Materials and Methods: Medical records of 347 (201 male and 146 female)..Outcome of pediatric heart transplantation recipients treated with ventricular assist device
Pediatric Transplantation
Nov 2012
Outcome of pediatric heart transplantation recipients treated with ventricular assist device
This study was conducted to evaluate the long-term prognosis of pediatric HTx patients treated with VAD before transplantation. The clinical data of six patients bridged to HTx with Berlin Heart EXCOR pediatric device were analyzed retrospectively. Information about graft function, CA results, and EMB findings as well..Pediatric Primary Urolithiasis: 12 Year Experience in a Mid-Western Children’s Hospital
Journal of Urology
Nov 2012
Pediatric Primary Urolithiasis: 12 Year Experience in a Mid-Western Children’s Hospital
Purpose: Due to environmental and social changes, including obesity, as new risk factors for stone formation in adults, and changes in imaging techniques utilized, the aims of this study were to assess if changes in etiologies of primary pediatric urolithiasis have occurred and if relationships exist between it and..Prophylactic magnesium for improving neurologic outcome after aneurysmal subarachnoid hemorrhage: Systematic review and meta-analysis
Journal of Critical Care
Nov 2012
Prophylactic magnesium for improving neurologic outcome after aneurysmal subarachnoid hemorrhage: Systematic review and meta-analysis
Purpose: Neurologic disability is common after aneurysmal subarachnoid hemorrhage (aSAH). Our objective was to systematically review the prophylactic use of magnesium to improve neurologic outcomes in these patients. Methods: We searched MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials to..Sensitive and rapid detection of viruses associated with hand foot and mouth disease using multiplexed MALDI-TOF analysis
Journal of Clinical Virology
Nov 2012
Sensitive and rapid detection of viruses associated with hand foot and mouth disease using multiplexed MALDI-TOF analysis
Background: Human enterovirus (HEV) is the major cause of hand foot and mouth disease (HFMD). A powerful method for detecting HEVs associated with HFMD can provide results in a clinically relevant time frame. However, the limitations of the current enterovirus test make it difficult to identify multiple genotypes on..Sixty- versus thirty-seconds papillary balloon dilation after sphincterotomy for the treatment of large bile duct stones: A randomized controlled trial
Digestive and Liver Disease
Nov 2012
Sixty- versus thirty-seconds papillary balloon dilation after sphincterotomy for the treatment of large bile duct stones: A randomized controlled trial
Background: Endoscopic biliary sphincterotomy followed by endoscopic papillary balloon dilation is a promising method for large stones. However, there are no data on the optimal duration of papillary balloon dilation after a biliary sphincterotomy. Aims: To compare the effectiveness and complications of the endoscopic..The prevalence and trends of transfusion-transmissible infectious pathogens among first-time, voluntary blood donors in Xi’an, China between 1999 and 2009
International Journal of Infectious Diseases
Nov 2012
The prevalence and trends of transfusion-transmissible infectious pathogens among first-time, voluntary blood donors in Xi’an, China between 1999 and 2009
Objectives: The prevalence of infectious diseases is increasing in developing countries, and this may threaten the biological safety of donated blood. This study analyzed trends in the prevalence of transfusion-transmissible infectious pathogens among Chinese, first-time, voluntary blood donors from 1999 to 2009 to..Body mass index influences prostate cancer risk at biopsy in Japanese men
International Journal of Urology
Nov 2012
Body mass index influences prostate cancer risk at biopsy in Japanese men
Objectives: To determine the relationship between body mass index and prostate cancer risk at biopsy in Japanese men, and to compared the risk with that of Caucasian men. Methods: We retrospectively evaluated 3966 men with prostate-specific antigen levels from 2.5 to 19.9 ng/mL who underwent an initial extended..Characteristics and Clinical Outcomes of Hyponatremia in Peritoneal Dialysis Patients
Nephrology
Nov 2012
Characteristics and Clinical Outcomes of Hyponatremia in Peritoneal Dialysis Patients
Aim: There are few reports on the incidence, etiology, and mortality of peritoneal dialysis (PD) patients with hyponatremia. Methods: We identified all adults (>18-years-of-age) who received PD between May 2001 and March 2010. The patients were divided into two groups according to the presence of hyponatremia (<135..Early results of a European multicentre experience with a new self-anchoring adjustable transobturator system for treatment of stress urinary incontinence in men
BJU International
Nov 2012
Early results of a European multicentre experience with a new self-anchoring adjustable transobturator system for treatment of stress urinary incontinence in men
What's known on the subject? and What does the study add? Surgical treatment options for male stress urinary incontinence (SUI) include collagen injection, artificial urinary sphincter, or male sling placement. In recent years, various minimally invasive sling systems have been investigated as treatment options for..Image-guided biopsy of small renal masses in the era of ablative therapies
International Journal of Urology
Nov 2012
Image-guided biopsy of small renal masses in the era of ablative therapies
Objective: To further evaluate the accuracy, safety, and impact of image-guided renal biopsies on clinical decision making and management of the indeterminate small renal masses. Methods: A total of 145 patients (males 99, females 46) with small renal masses suspicious for malignancy were evaluated during the study..Intrarenal reflux in primary vesicoureteral reflux
International Journal of Urology
Nov 2012
Intrarenal reflux in primary vesicoureteral reflux
Objectives: To elucidate the significance of intrarenal reflux. Methods: We retrospectively analyzed 276 patients (age <5 years) with grade III to V vesicoureteral reflux. They were divided into two groups: 55 patients with intrarenal reflux and 221 patients without intrarenal reflux (control group). All patients..Local recurrence after retropubic radical prostatectomy for prostate cancer does not exclusively occur at the anastomotic site
BJU International
Nov 2012
Local recurrence after retropubic radical prostatectomy for prostate cancer does not exclusively occur at the anastomotic site
What's known on the subject? and What does the study add? Local recurrence after radical prostatectomy (RP) for clinically organ-confined prostate cancer is largely assumed to occur at the anastomotic site, as reflected in European and North American guidelines for adjuvant and salvage radiotherapy after RP. However,..Optimal strategy for penile rehabilitation after robot-assisted radical prostatectomy based on preoperative erectile function
BJU International
Nov 2012
Optimal strategy for penile rehabilitation after robot-assisted radical prostatectomy based on preoperative erectile function
What's known on the subject? and What does the study add? Removing of prostate for the treatment of localized prostate cancer is associated with a variable loss of erectile function due to injury of the nerves of erection during operation. Some researchers have reported that after nerve-sparing radical prostatectomy..Preoperative masked renal damage in Japanese patients with primary aldosteronism: Identification of predictors for chronic kidney disease manifested after adrenalectomy
International Journal of Urology
Nov 2012
Preoperative masked renal damage in Japanese patients with primary aldosteronism: Identification of predictors for chronic kidney disease manifested after adrenalectomy
Objective: Correct interpretation of renal function in patients with primary aldosteronism is difficult before adrenalectomy, because subtle kidney impairment is often masked by glomerular hyperfiltration peculiar to primary aldosteronism. The aim of this study was to investigate postoperative changes in renal function..Risk factors for chronic kidney disease after chemotherapy for testicular cancer
International Journal of Urology
Nov 2012
Risk factors for chronic kidney disease after chemotherapy for testicular cancer
Objective: To elucidate the patterns of and risk factors for deterioration of renal function after chemotherapy in metastatic testicular cancer survivors using the estimated glomerular filtration rate. Methods: A total of 96 patients who were treated with cisplatin-based chemotherapy for metastatic testicular cancer..Typhoid Fever in an Inner City Hospital: A 5-Year Retrospective Review
Journal of Travel Medicine
Nov 2012
Typhoid Fever in an Inner City Hospital: A 5-Year Retrospective Review
Background: Typhoid is a leading cause of fever in returning travelers. The prevalence is highest in migrants visiting friends and relatives (VFR travelers) in the Indian subcontinent, where reports of resistance have been of concern. This study is a retrospective analysis of patients with typhoid, seen over a 5-year..Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1 driven T-ALL
Experimental Hematology
Nov 2012
Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1 driven T-ALL
Activating mutations of NOTCH1 and deletion of the INK4A-ARF (CDKN2A) tumor suppressor locus are two of the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL). In a murine model of T-ALL induced by the intracellular domain of Notch1 (ICN1), the genetic interaction between ICN1 signaling..Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple Myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules
Experimental Hematology
Nov 2012
Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple Myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules
Multiple myeloma (MM)-induced osteoclast (OC) formation is mainly due to an imbalance of the receptor activator of NF-kappa-B ligand (RANKL)/osteoprotegerin (OPG) ratio in favor of RANKL in the bone microenvironment and to the CCL3 production by MM cells. The purpose of the study was to investigate the effect of the..In the shadow of terror: Posttraumatic stress and psychiatric co-morbidity following bombing in Iraq: The role of shattered world assumptions and altered self-capacities
Journal of Psychiatric Research
Nov 2012
In the shadow of terror: Posttraumatic stress and psychiatric co-morbidity following bombing in Iraq: The role of shattered world assumptions and altered self-capacities
Whilst research has looked at posttraumatic stress disorder (PTSD) and psychiatric co-morbidity among civilians exposed to bombing, there is a lack of longitudinal data on the development of these outcomes and the psychological factors associated with them, particularly among Iraqi civilians. This study aimed to:..Induction and Maintenance Treatment of Proliferative Lupus Nephritis: A Meta-Analysis of Randomized Controlled Trials
American Journal of Kidney Diseases
Nov 2012
Induction and Maintenance Treatment of Proliferative Lupus Nephritis: A Meta-Analysis of Randomized Controlled Trials
Background: Lupus nephritis accounts for ∼1% of patients starting dialysis therapy. Treatment regimens combining cyclophosphamide with steroids preserve kidney function but have significant side effects. Newer immunosuppressive agents may have improved toxicity profiles. Study Design: Systematic review and..Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma
Digestive and Liver Disease
Nov 2012
Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma
Hepatocellular carcinoma and cholangiocarcinoma are primary liver cancers, both represent a growing challenge for clinicians due to their increasing morbidity and mortality. In the last few years a number of in vivo models of hepatocellular carcinoma and cholangiocarcinoma have been developed. The study of these models..Magnesium and the obstetric anaesthetist
International Journal of Obstetric Anesthesia
Nov 2012
Magnesium and the obstetric anaesthetist
Magnesium is one of the most abundant cations in the human body. It is utilised extensively within the medical world and its role in the treatment of various conditions in both mother and fetus is increasing. This review focuses on the importance of magnesium for the obstetric anaesthetist and looks at the most recent..miR-133a mediates TGF-β-dependent de-repression of collagen-synthesis in hepatic stellate cells during liver fibrosis
Journal of Hepatology
Nov 2012
miR-133a mediates TGF-β-dependent de-repression of collagen-synthesis in hepatic stellate cells during liver fibrosis
Background & Aims: miRNAs are novel regulators of organ fibrosis. miR-133a plays a role in cardiac and muscle remodeling, but its function in the liver is unclear. We therefore aimed at evaluating a possible function of miR-133a in hepatofibrogenesis. Methods: miR-133a levels were measured in whole liver samples from..Molecular epidemiology of hepatitis C virus genotypes in different geographical regions of Punjab Province in Pakistan and a phylogenetic analysis
International Journal of Infectious Diseases
Nov 2012
Molecular epidemiology of hepatitis C virus genotypes in different geographical regions of Punjab Province in Pakistan and a phylogenetic analysis
Background: Hepatitis C virus (HCV) is a causative agent of chronic liver disease, cirrhosis, and hepatocellular carcinoma. In Pakistan, more than 10 million people are living with HCV. Very little is known about the genotype distribution in Punjab Province, the largest province of Pakistan. Pretreatment genotype..Mouse KLF11 regulates hepatic lipid metabolism
Journal of Hepatology
Nov 2012
Mouse KLF11 regulates hepatic lipid metabolism
Background & Aims: Missense mutations in human Krüppel-like factor 11 (KLF11) lead to the development of diabetes as a result of impaired insulin synthesis in the pancreas. However, the role of KLF11 in peripheral tissues is largely unknown. The objective of this study is to evaluate the role of KLF11 in the regulation..Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins
Journal of Hepatology
Nov 2012
Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins
Non-alcoholic steatohepatitis (NASH) is hallmarked by lipid accumulation in the liver (steatosis) along with inflammation (hepatitis). The transition from simple steatosis towards NASH represents a key step in pathogenesis, as it will set the stage for further severe liver damage. Yet, the pathogenesis behind hepatic..Non-Invasive Diagnosis of Non-Alcoholic Fatty Liver Disease – A Critical Appraisal
Journal of Hepatology
Nov 2012
Non-Invasive Diagnosis of Non-Alcoholic Fatty Liver Disease – A Critical Appraisal
Non-alcoholic fatty liver disease (NAFLD) affects one in every three subjects in the occidental world. The vast majority will not progress, but a relevant minority will develop liver cirrhosis and its complications. The classical gold-standard for diagnosing and staging NAFLD and assessing fibrosis is liver biopsy..Performance of rapid tests for detection of HBsAg and anti-HBsAb in a large cohort, France
Journal of Hepatology
Nov 2012
Performance of rapid tests for detection of HBsAg and anti-HBsAb in a large cohort, France
Background and Aims: The systematic use of rapid tests performed at points-of-care may facilitate hepatitis B virus (HBV) screening and substantially increase HBV infection awareness. The objective of this study was to evaluate the effectiveness of such tests for HBsAg and anti-HBsAb detection among individuals..Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice
Experimental Hematology
Nov 2012
Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice
The CXCR4 antagonist Plerixafor (AMD3100) induces the rapid mobilization of hematopoietic stem and progenitor cells into the blood in mice and humans. AMD3100 similarly induces the mobilization of human acute lymphoblastic leukemia (ALL) cells into the blood in mice. In this study, the temporal response of pre-B ALL..Primary Prevention of Allergic Disease Through Nutritional Interventions
Journal of Allergy and Clinical Immunology
Nov 2012
Primary Prevention of Allergic Disease Through Nutritional Interventions
With the rising prevalence of atopic disease, primary prevention may play a role in reducing its burden, especially in high-risk infants. With this in mind, the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology was charged with the task of developing recommendations for..Quantification of cytomegalovirus DNA by a fully automated real-time PCR for early diagnosis and monitoring of active viral infection in solid organ transplant recipients
Journal of Clinical Virology
Nov 2012
Quantification of cytomegalovirus DNA by a fully automated real-time PCR for early diagnosis and monitoring of active viral infection in solid organ transplant recipients
Background: Quantification of cytomegalovirus (CMV) DNA by real-time PCR is currently considered an alternative diagnostic approach for the evaluation of active infection in transplant patients. The pp65 antigenemia assay has been used as reference test for monitoring active CMV infection and guiding preemptive therapy..Re-evaluation of the VIDAS® cytomegalovirus (CMV) IgG avidity assay: Determination of new cut-off values based on the study of kinetics of CMV–IgG maturation
Journal of Clinical Virology
Nov 2012
Re-evaluation of the VIDAS® cytomegalovirus (CMV) IgG avidity assay: Determination of new cut-off values based on the study of kinetics of CMV–IgG maturation
Background: In case of cytomegalovirus (CMV) infection, differentiation between primary and non-primary CMV infection can be of major importance for the correct management of pregnant women or immunocompromised patients. Besides CMV–IgM and IgG, CMV–IgG avidity measurement is now commonly used to distinguish primary..Relationship between hospital antibiotic use and quinolone resistance in Escherichia coli
International Journal of Infectious Diseases
Nov 2012
Relationship between hospital antibiotic use and quinolone resistance in Escherichia coli
Background: The relationship between the hospital use of various classes of antibiotics and resistance of Escherichia coli to quinolones remains debated. Our aim was to study the relationship between the hospital use of 16 classes of antibacterial agents and the incidence of quinolone-resistant E. coli isolates...Review of Streptococcal Bloodstream Infections at a Comprehensive Cancer Care Center, 2000-2011
Journal of Infection
Nov 2012
Review of Streptococcal Bloodstream Infections at a Comprehensive Cancer Care Center, 2000-2011
Objectives: To determine the comparative rates, clinical characteristics, and outcomes of invasive infections due to specific streptococcal types in patients with cancer. Methods: Review of electronic medical records of patients with non-viridans group streptococcal bloodstream infection (BSI) at the MD Anderson Cancer..Risk Perception of Travelers to Tropical and Subtropical Countries Visiting a Swiss Travel Health Center
Journal of Travel Medicine
Nov 2012
Risk Perception of Travelers to Tropical and Subtropical Countries Visiting a Swiss Travel Health Center
Background: This study assessed the risk perception ratings of travelers pre- and post-travel and in comparison to the ratings by travel health experts. While most surveys on travel health knowledge, attitudes, and practices focus on malaria and vaccine-preventable diseases, noninfectious travel risks were included in..Salvage surgery of vestibular schwannoma after failed radiotherapy: The Gruppo Otologico experience and review of the literature
American Journal of Otolaryngology
Nov 2012
Salvage surgery of vestibular schwannoma after failed radiotherapy: The Gruppo Otologico experience and review of the literature
Objectives: The use of radiation therapy has largely widespread and becomes in many centers the preference modality of treatment for symptomatic patients who are old, medically unfit for surgical therapy, those who refuse surgery and in some recurrent or residual growing tumors. The risk of radiotherapy failure in the..Short parenteral antibiotic treatment for adult septic arthritis after successful drainage
International Journal of Infectious Diseases
Nov 2012
Short parenteral antibiotic treatment for adult septic arthritis after successful drainage
Objectives: To assess the risk factors for recurrence of septic arthritis with an emphasis on the duration of antibiotic treatment, to gather data for a prospective study on an optimized antibiotic treatment in adults with septic arthritis. Methods: This was a retrospective single-center study conducted for the period..Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: a randomized, 28-day, dose-ranging trial
Journal of Hepatology
Nov 2012
Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: a randomized, 28-day, dose-ranging trial
Background and Aims: Sofosbuvir (formerly GS-7977) is a pyrimidine nucleotide analog inhibitor of the hepatitis C virus (HCV) NS5B polymerase. We assessed the safety, tolerability, antiviral activity, and pharmacokinetics of sofosbuvir plus pegylated-interferon (peg-IFN)/ribavirin (RBV) in a 28-day, dose-ranging trial..Stroma-dependent development of two dendritic-like cell types with distinct antigen presenting capability
Experimental Hematology
Nov 2012
Stroma-dependent development of two dendritic-like cell types with distinct antigen presenting capability
Novel APC have been described in murine spleen. Cells have a distinct CD11cloCD11bhiMHC-II-CD8α- phenotype as highly endocytic dendritic-like cells which cross-present antigen to CD8+ T cells but fail to activate CD4+ T cells. They are named ‘L-DC’ since they reflect cells produced in longterm spleen cultures (LTC-DC)...Substance P antagonist improves both obesity and asthma in a mouse model
Allergy
Nov 2012
Substance P antagonist improves both obesity and asthma in a mouse model
Background: Evidence suggests a causal relationship between obesity and asthma; however, the underlying mechanisms remain unknown. Substance P (SP), involved in neurogenic inflammation by acting through its receptor NK1-R, seems to participate in obese–asthma phenotype in mice. Objectives: To evaluate the effect of a..Sustained virologic response rates with telaprevir by response after 4 weeks of lead-in therapy in patients with prior treatment failure
Journal of Hepatology
Nov 2012
Sustained virologic response rates with telaprevir by response after 4 weeks of lead-in therapy in patients with prior treatment failure
Background & Aims: For hepatitis C virus (HCV)-infected patients who have not responded to previous peginterferon/ribavirin treatment, it is unclear whether subsequent direct-acting antiviral therapy outcomes are better predicted by prior treatment response or by on-treatment response to a peginterferon/ribavirin..The impact of spinal anaesthesia for caesarean delivery on coagulation assessed by thromboelastography
International Journal of Obstetric Anesthesia
Nov 2012
The impact of spinal anaesthesia for caesarean delivery on coagulation assessed by thromboelastography
Background: Pregnancy and puerperium are associated with a hypercoagulable state. The aim of the study was to assess the impact of spinal anaesthesia on coagulation using thromboelastography in healthy term pregnant women undergoing elective caesarean delivery. Methods: Thromboelastography was performed on 60 women..Timing of infant feeding in relation to childhood asthma and allergic diseases
Journal of Allergy and Clinical Immunology
Nov 2012
Timing of infant feeding in relation to childhood asthma and allergic diseases
Background: Emerging evidence questions current recommendations on the timing of infant feeding for the prevention of childhood allergies. The evidence for asthma is inconclusive. Objective: We sought to investigate the associations between the duration of breast-feeding and timing of introduction of complementary..Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
Leukemia Research
Nov 2012
Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
The main objective of this systematic review is to quantify and to summarize all studies that have included health-related quality of life (HRQOL) or, any other type of patient-reported outcomes (PROs), in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Nine papers were..Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection
Journal of Hepatology
Nov 2012
Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection
Background & Aims: The relationship between vitamin D status and response to antiviral therapy and liver histology in hepatitis C virus genotype 1 (HCV-1) infection remains unclear with studies to date yielding inconsistent results and failing to use reference assay methodology. We therefore analyzed pre-treatment..A dose–response study of remifentanil for attenuation of the hypertensive response to laryngoscopy and tracheal intubation in severely preeclamptic women undergoing caesarean delivery under general anaesthesia
International Journal of Obstetric Anesthesia
Nov 2012
A dose–response study of remifentanil for attenuation of the hypertensive response to laryngoscopy and tracheal intubation in severely preeclamptic women undergoing caesarean delivery under general anaesthesia
Background: Remifentanil is known to attenuate the cardiovascular responses to tracheal intubation. We determined effective doses (ED50/ED95) of remifentanil to prevent the pressor response to tracheal intubation in patients with severe preeclampsia. Methods: Seventy-five women with severe preeclampsia were randomly..Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA 2 LEN survey
Allergy
Nov 2012
Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA 2 LEN survey
Background: Asthma and rhinitis have been related to insomnia. The aim of this study was to further analyse the association between asthma, nasal symptoms and insomnia and to identify risk factors for sleep disturbance among patients with asthma, in a large population-based set of material. Method: In 2008, a postal..Autologous stem cell transplantation: An effective salvage therapy in multiple myeloma
Biology of Blood and Marrow Transplantation
Nov 2012
Autologous stem cell transplantation: An effective salvage therapy in multiple myeloma
Eighty-one patients treated with high-dose therapy and autologous stem cell transplantion (ASCT) as part of salvage therapy after a frontline ASCT were included in a retrospective analysis. The median time between the first and the salvage ASCT was 47 months. Following salvage ASCT, 75 patients (93%) achieved at least..BCG vaccination is associated with decreased severity of tuberculosis in Pakistan
International Journal of Mycobacteriology
Nov 2012
BCG vaccination is associated with decreased severity of tuberculosis in Pakistan
Vaccination with Bacille Calmette–Guérin (BCG) is given at birth to protect against tuberculosis (TB) in Pakistan. The country ranks 6th amongst high-burden countries worldwide and has an incidence of 231/100,000 pyopulation. This was a cross-sectional multi-center hospital-based study. TB patients (n=218) with..Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Leukemia Research
Nov 2012
Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Spurred by previous observations we assessed the relationship between offspring birth weight and parental leukaemia risk in a register-based investigation including 2.4 million parents of 2 million Danish children. Regardless of analytical approach, offspring birth weight was not associated with parental risk of..Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course
Journal of Psychiatric Research
Nov 2012
Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course
Background: Gene–environment interactions may contribute to bipolar disorder (BD) clinical course variability. We examined effects of brain-derived neurotrophic factor (BDNF) val66met genotype and early life stress (ELS) upon illness severity and chronicity in adult BD patients. Methods: 80 patients (43 BD I, 33 BD II,..Cognitive behaviour therapy for chronic subjective dizziness: longer-term gains and predictors of disability
American Journal of Otolaryngology
Nov 2012
Cognitive behaviour therapy for chronic subjective dizziness: longer-term gains and predictors of disability
Purpose: The study sought to evaluate the longer-term effects of a brief cognitive behaviour therapy (CBT) intervention for patients with chronic subjective dizziness (CSD). In addition, it sought to identify predictors of longer-term disability in this group. Materials and methods: Forty-four patients with CSD..Design and evaluation of tinnitus synthesis methods: From spectral to spatial matching
American Journal of Otolaryngology
Nov 2012
Design and evaluation of tinnitus synthesis methods: From spectral to spatial matching
Purpose: This study was designed to investigate methods to help patients suffering from unilateral tinnitus synthesizing an auditory replica of their tinnitus. Materials and methods: Two semi-automatic methods (A and B) derived from the auditory threshold of the patient and a method (C) combining a pure tone and a..Detection and genotyping of human papillomavirus by real-time PCR assay
Journal of Clinical Virology
Nov 2012
Detection and genotyping of human papillomavirus by real-time PCR assay
Background: Diagnosis of human papillomavirus (HPV) disease remains a challenge due to several factors related to the cost, the workload of available commercial assays to detect and genotype HPV, and to the low prevalence of infected patients. Objective: Our study aimed to develop a real-time PCR, based on SPF10..Diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small-bowel disease: Results of the Italian multicentre study
Digestive and Liver Disease
Nov 2012
Diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small-bowel disease: Results of the Italian multicentre study
Background: Limited data are available on the clinical impact of single balloon enteroscopy. Aims: To evaluate the diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small bowel disease. Methods: Data on patients with suspected small bowel disease based on non-invasive imaging,..Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice
Journal of Allergy and Clinical Immunology
Nov 2012
Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice
Background: The prevalence of peanut allergies is increasing. Peanuts and many other allergen sources contain significant amounts of triglycerides, which affect absorption of antigens but have unknown effects on sensitization and anaphylaxis. We recently reported that dietary medium-chain triglycerides (MCTs), which..DJ-1 regulates mast cell activation and IgE-mediated allergic responses
Journal of Allergy and Clinical Immunology
Nov 2012
DJ-1 regulates mast cell activation and IgE-mediated allergic responses
Background: DJ-1 is an antioxidant protein known to reduce levels of reactive oxygen species (ROS), but its presence or function in mast cells and allergic diseases is unknown. Objectives: We sought to determine the role and mechanism of DJ-1 in allergic responses in vitro and in vivo. Methods: ROS and DJ-1 levels in..Dual Oral Therapy with Daclatasvir and Asunaprevir for Patients with HCV Genotype 1b Infection and Limited Treatment Options
Journal of Hepatology
Nov 2012
Dual Oral Therapy with Daclatasvir and Asunaprevir for Patients with HCV Genotype 1b Infection and Limited Treatment Options
Background & Aims: Improved therapeutic options for chronic hepatitis C virus (HCV) infection are needed for patients who are poor candidates for treatment with current regimens due to anticipated intolerability or low likelihood of response. Methods: In this open-label, phase 2a study of Japanese patients with chronic..Efficacy and Safety of Boceprevir plus Peginterferon-Ribavirin in Patients with HCV G1 Infection and Advanced Fibrosis/Cirrhosis
Journal of Hepatology
Nov 2012
Efficacy and Safety of Boceprevir plus Peginterferon-Ribavirin in Patients with HCV G1 Infection and Advanced Fibrosis/Cirrhosis
Background and Aims: We assessed the safety and efficacy of boceprevir (BOC) plus peginterferon-ribavirin (PR) in patients with HCV-G1 infection and advanced fibrosis/cirrhosis (Metavir F3/F4). Methods: In two randomized controlled studies in previously untreated and previous treatment-failures, patients received a..Albumin Infusion Improves Outcomes of Patients with Spontaneous Bacterial Peritonitis: A Meta-Analysis of Randomized Trials
Clinical Gastroenterology and Hepatology
Nov 2012
Albumin Infusion Improves Outcomes of Patients with Spontaneous Bacterial Peritonitis: A Meta-Analysis of Randomized Trials
Background & Aims: Renal impairment increases mortality among patients with spontaneous bacterial peritonitis (SBP), despite administration of non-nephrotoxic antibiotics. Albumin infusion has been reported to reduce renal impairment and mortality in patients with SBP. We performed a meta-analysis of randomized..Aspergillus meningitis : a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases
Journal of Infection
Nov 2012
Aspergillus meningitis : a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases
Objectives: To describe the pathogenesis, clinical presentation, cerebrospinal fluid findings and outcome of Aspergillus meningitis, meningoencephalitis and arachnoiditis. Methods: A case of Aspergillus meningitis is described. A comprehensive review of the English-language literature was conducted to identify all..Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
Journal of Hepatology
Nov 2012
Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with a twofold greater risk of developing cardiovascular disease than those without. Despite this, little is known about the effect of NAFLD upon cardiac function, limiting our ability to identify therapeutic strategies. This study aimed to..Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir
Journal of Hepatology
Nov 2012
Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir
Background and Aims: Daclatasvir and asunaprevir are NS5A- and NS3 protease-targeted antivirals currently under development for treatment of chronic hepatitis C virus infection. Clinical data on baseline and on-treatment correlates of drug resistance and response to these agents are currently limited. Methods:..Comparison of resection and ablation for hepatocellular carcinoma: a cohort study based on a Japanese nationwide survey
Journal of Hepatology
Nov 2012
Comparison of resection and ablation for hepatocellular carcinoma: a cohort study based on a Japanese nationwide survey
Background & Aims: The treatment of choice for early or moderately advanced hepatocellular carcinoma (HCC) with good liver function remains controversial. We evaluated the therapeutic impacts of surgical resection (SR), percutaneous ethanol injection (PEI), and radiofrequency ablation (RFA) on long-term outcomes in..Contemporary management of pediatric lateral sinus thrombosis: A twenty year review
American Journal of Otolaryngology
Nov 2012
Contemporary management of pediatric lateral sinus thrombosis: A twenty year review
Objectives: A case of pediatric otogenic lateral sinus thrombosis is reported, followed by a substantive literature review. Design: 104 patients were reviewed, culled from published case reports from 1993 to 2011 on the PubMed database. Methods: All full text case reports on the PubMed database from 1993 to 2011 with..Estimating the Total Incidence of Kidney Failure in Australia Including Individuals Who Are Not Treated by Dialysis or Transplantation
American Journal of Kidney Diseases
Nov 2012
Estimating the Total Incidence of Kidney Failure in Australia Including Individuals Who Are Not Treated by Dialysis or Transplantation
Background: To date, incidence data for kidney failure in Australia have been available for only those who start renal replacement therapy (RRT). Information about the total incidence of kidney failure, including non–RRT-treated cases, is important to help understand the burden of kidney failure in the community and..Evaluation of 4 immunochromatographic tests for rapid detection of norovirus in faecal samples
Journal of Clinical Virology
Nov 2012
Evaluation of 4 immunochromatographic tests for rapid detection of norovirus in faecal samples
Background: The rapid detection of noroviruses is essential to implement measures to reduce the rapid spread of gastroenteritis infections they cause, notably in institutions. Objectives: To evaluate 4 rapid immunochromatographic tests: RIDA®QUICK Norovirus, ImmunoCardSTAT!® Norovirus, NOROTOP® and SD BIOLINE NOROVIRUS..HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters
Journal of Psychiatric Research
Nov 2012
HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters
Decision-making impairment is found in several neuropsychiatric disorders, including suicidal behavior, and has been shown to be modulated by genes. On the other hand, early trauma have/has been associated with poor mental health outcome in adulthood, in interaction with genetic factors, possibly through sustained..Influence of Maternal and Paternal Birthweight on Offspring Birthweight – a Population-based Intergenerational Study
Paediatric and Perinatal Epidemiology
Nov 2012
Influence of Maternal and Paternal Birthweight on Offspring Birthweight – a Population-based Intergenerational Study
Background The correlation between infant birthweight and parental birthweight has received substantial interest. However, fewer studies including the birthweight of the father have had access to large sets of population-based data. The objective of this study is to examine the influence of maternal and paternal..Lymphadenectomy around the left renal vein in Siewert type II adenocarcinoma of the oesophagogastric junction
British Journal of Surgery
Nov 2012
Lymphadenectomy around the left renal vein in Siewert type II adenocarcinoma of the oesophagogastric junction
Background: The extent of lymphadenectomy in patients with Siewert type II adenocarcinoma of the oesophagogastric junction is controversial. The aim of this study was to investigate lymph node involvement around the left renal vein. Methods: Lymph node involvement and prognosis in patients with Siewert type II cancers..Lymphopenia as a novel marker of Clostridium difficile infection recurrence
Journal of Infection
Nov 2012
Lymphopenia as a novel marker of Clostridium difficile infection recurrence
Background: Treatment of Clostridium difficile infection (CDI) is often limited by recurrence in 25% of cases. The objective of this study was to determine risk factors of CDI recurrence during a provincial endemic. Methods: Data was prospectively collected for 1 year in a Montréal hospital. Inclusion criteria were:..Modelling the cost-effectiveness of carotid endarterectomy for asymptomatic stenosis
British Journal of Surgery
Nov 2012
Modelling the cost-effectiveness of carotid endarterectomy for asymptomatic stenosis
Background: The aim of this study was to model the cost-effectiveness of carotid endarterectomy for asymptomatic stenosis versus medical therapy based on 10-year data from the Asymptomatic Carotid Surgery Trial (ACST). Methods: This was a cost–utility analysis based on clinical effectiveness data from the ACST with..Recurrence pattern in patients with a pathologically complete response after neoadjuvant chemoradiotherapy and surgery for oesophageal cancer
British Journal of Surgery
Nov 2012
Recurrence pattern in patients with a pathologically complete response after neoadjuvant chemoradiotherapy and surgery for oesophageal cancer
Background: Little is known about recurrence patterns in patients with a pathologically complete response (pCR) or an incomplete response after neoadjuvant chemoradiotherapy (CRT) followed by resection for oesophageal cancer. This study was performed to determine the pattern of recurrence in patients with a pCR after..The added value of quality of life (QoL) for prognoses of overall survival in patients with palliative hepatocellular carcinoma
Journal of Hepatology
Nov 2012
The added value of quality of life (QoL) for prognoses of overall survival in patients with palliative hepatocellular carcinoma
Background: Several prognostic classifications (PCs) have been developed for use in palliative care for patients with hepatocellular carcinoma (HCC). We recently suggested that CLIP combined with WHO PS had the greatest discriminative power. We evaluated the prognostic value of quality of life (QoL) data and whether..The incidence and magnitude of fibrinolytic activation in trauma patients
Journal of Thrombosis and Haemostasis
Nov 2012
The incidence and magnitude of fibrinolytic activation in trauma patients
Background: Trauma is a global disease with over 2.5 million deaths annually from haemorrhage and coagulopathy. Overt hyperfibrinolysis is rare in trauma and associated with massive fatal injuries. Paradoxically, clinical trials suggest a much broader indication for antifibrinolytics. Objective: To determine the..The Perspectives of Adults Living With Peritoneal Dialysis: Thematic Synthesis of Qualitative Studies
American Journal of Kidney Diseases
Nov 2012
The Perspectives of Adults Living With Peritoneal Dialysis: Thematic Synthesis of Qualitative Studies
Background: Most patients with end-stage renal disease require dialysis to survive because they are unable to access kidney transplantation. Peritoneal dialysis (PD) is recommended by some clinical practice guidelines as the dialysis treatment of choice for adults without significant comorbid conditions or those with..A 64,489-patient full-disclosure database of cardiovascular risk factors and events status analysed in a Bayesian framework: A unique contribution to predictive science
International Journal of Cardiology
Nov 2012
A 64,489-patient full-disclosure database of cardiovascular risk factors and events status analysed in a Bayesian framework: A unique contribution to predictive science
Today in the International Journal of Cardiology Liu et al. [1] publish an unusual exercise in open science which should set a pioneering trend for future knowledge sharing. They present both the principle and a large fully-analysed real world dataset to show how Bayesian reasoning can be practically helpful for..Achievement of deep remission during scheduled maintenance therapy with TNFα-blocking agents in IBD
Journal of Crohn's and Colitis
Nov 2012
Achievement of deep remission during scheduled maintenance therapy with TNFα-blocking agents in IBD
Background and Aims: Deep remission, meaning clinical remission with mucosal healing (MH), with anti-tumor necrosis factor-alpha (TNF-α) agents is a new target for therapy in inflammatory bowel disease (IBD). Our aim was to study how often patients on TNF-α blocking therapy actually achieve deep remission. Methods: The..Acupuncture for neurogenic bladder after spinal cord injury: A systematic review and meta-analysis
European Journal of Integrative Medicine
Nov 2012
Acupuncture for neurogenic bladder after spinal cord injury: A systematic review and meta-analysis
Introduction: The objective of this study is to evaluate the efficacy and safety of acupuncture for neurogenic bladder after spinal cord injury (SCI). Methods: Data up to September 2012 were from 7 databases. Randomized-controlled clinical trials (RCTs) on acupuncture for neurogenic bladder after SCI were included...Age-dependent inequalities in improvements in mortality occur early after acute myocardial infarction in 478,242 patients in the Myocardial Ischaemia National Audit Project (MINAP) registry
International Journal of Cardiology
Nov 2012
Age-dependent inequalities in improvements in mortality occur early after acute myocardial infarction in 478,242 patients in the Myocardial Ischaemia National Audit Project (MINAP) registry
Background: Mortality rates after acute myocardial infarction (AMI) have declined, but there is uncertainty regarding the extent of improvements in early mortality in the elderly. Methods: Mixed-effects regression analysis of 30-day mortality using data from 478,242 patients with AMI at 215 hospitals in England and..Anuric Acute Kidney Injury in Neurofibromatosis 1
American Journal of Kidney Diseases
Nov 2012
Anuric Acute Kidney Injury in Neurofibromatosis 1
Neurofibromatosis is one of several genetic disorders characterized by hyperpigmented skin spots (café au lait spots) and multiple neurofibromas. It was first reported by Friedrich Daniel von Recklinghausen in 1882. There are 2 types of neurofibromatosis described in the literature: von Recklinghausen disease, or..Are we overlooking infections owing to non-tuberculous mycobacteria during routine conventional laboratory investigations?
International Journal of Mycobacteriology
Nov 2012
Are we overlooking infections owing to non-tuberculous mycobacteria during routine conventional laboratory investigations?
A large number of potentially pathogenic non-tuberculous mycobacteria (NTM) encountered in the clinical laboratory makes it necessary to identify their species to ensure appropriate treatment. However, labor-intensive conventional methods of speciation are not used in every laboratory, and hence NTM infections are..Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages
Neurobiology of Aging
Nov 2012
Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages
Aberrant complement activation is known to exacerbate the pathology in a spectrum of degenerative diseases of aging. We previously reported that aurin tricarboxylic acid (ATA) is an orally effective agent which prevents formation of the membrane attack complex of complement. It inhibits C9 attachment to tissue bound..Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
Leukemia Research
Nov 2012
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms, in which a stem cell lesion induces an autonomous proliferative advantage. In addition to the JAK2V617 mutation several other mutations have been described. Recently chronic inflammation has been proposed as a..Comparisons among the diagnostic methods used for the detection of extra-pulmonary tuberculosis in Bangladesh
International Journal of Mycobacteriology
Nov 2012
Comparisons among the diagnostic methods used for the detection of extra-pulmonary tuberculosis in Bangladesh
The present study was an attempt to establish a suitable method for the effective diagnosis of extra-pulmonary tuberculosis in Bangladesh. In this regard, detection of Mycobacterium tuberculosis from 390 different extra-pulmonary specimens was performed by Bright-Field microscopy, light-emitting diode fluorescence..Determinants of emergency medical utilization among the elderly population in Taiwan: A national longitudinal cohort study
Archives of Gerontology and Geriatrics
Nov 2012
Determinants of emergency medical utilization among the elderly population in Taiwan: A national longitudinal cohort study
The aim of this study was to evaluate the potential determinants for emergency medical utilization by elderly patients in Taiwan. The data were drawn from the ‘Survey of Health and Living Status of the Elderly in Taiwan’, a population-based, longitudinal study of a nationally representative random sample of older..Effect of Isoflavone on Balloon Catheter-Induced Neointimal Hyperplasia in Ovariectomised Rabbit Carotid Artery
Heart, Lung and Circulation
Nov 2012
Effect of Isoflavone on Balloon Catheter-Induced Neointimal Hyperplasia in Ovariectomised Rabbit Carotid Artery
Background: This study was designed to investigate the effects of phytoestrogen isoflavone on balloon catheter-induced hyperplasia of carotid artery. Methods: Forty-eight female New Zealand rabbits were randomly divided into four groups: control (balloon-induced carotid artery injury only); ovariectomy control..Genetics of graft-versus-host disease: The major histocompatibility complex
Blood Reviews
Nov 2012
Genetics of graft-versus-host disease: The major histocompatibility complex
Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but the best characterized genetic system is that of the human major histocompatibility complex (MHC) located on chromosome 6. Among the..Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology
International Journal of Cardiology
Nov 2012
Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology
Sarcopenia and cachexia are significant medical problems with a high disease related burden in cardiovascular illness. Muscle wasting and weight loss are very frequent particularly in chronic heart failure and they relate to poor prognosis. Although clinically largely underestimated, the fields of cachexia and..HIV-1 co-receptor expression and epithelial immune cells of the cervix in asymptomatic women attending a genitourinary medicine clinic
HIV Medicine
Nov 2012
HIV-1 co-receptor expression and epithelial immune cells of the cervix in asymptomatic women attending a genitourinary medicine clinic
Objectives: The aim of the study was to qualitatively and semiquantitatively characterize the expression of the principal HIV co-receptors chemokine (C-C motif) receptor 5 (CCR5) and chemokine (C-X-C motif) receptor 4 (CXCR4) on susceptible CD4 T-helper cell, monocyte/macrophage and Langerhans dendritic cell..Impact of baseline HIV-1 RNA levels on initial highly active antiretroviral therapy outcome: a meta-analysis of 12,370 patients in 21 clinical trials
HIV Medicine
Nov 2012
Impact of baseline HIV-1 RNA levels on initial highly active antiretroviral therapy outcome: a meta-analysis of 12,370 patients in 21 clinical trials
Background: Individual randomized trials of first-line antiretroviral treatment do not consistently show an association between higher baseline HIV-1 RNA and lower efficacy. Methods: A MEDLINE search identified 21 HIV clinical trials with published analyses of antiretroviral efficacy by baseline HIV-1 RNA, using a..Impact of obesity on the cost of major colorectal surgery
British Journal of Surgery
Nov 2012
Impact of obesity on the cost of major colorectal surgery
Background: The incidence of obesity is increasing in New Zealand. The aim of the study was to determine whether obesity impacts on the cost of treating patients undergoing major colorectal surgery. Methods: Between 1 February 2008 and 31 July 2009, consecutive patients undergoing major colorectal surgery at..Infliximab as a rescue-treatment in difficult-to-treat autoimmune hepatitis
Journal of Hepatology
Nov 2012
Infliximab as a rescue-treatment in difficult-to-treat autoimmune hepatitis
Background: Autoimmune hepatitis is a chronic inflammatory liver disease that leads to liver cirrhosis and corresponding complications if left untreated. Current standard treatment with azathioprine and prednisolone induces remission in the vast majority of patients. However, for those patients not responding to..Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment
British Journal of Surgery
Nov 2012
Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment
Background: Clinical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap reconstruction in relation to complications and adjuvant..miR-122 Regulates Collagen Production via Targeting Hepatic Stellate Cells and Suppressing P4HA1 Expression
Journal of Hepatology
Nov 2012
miR-122 Regulates Collagen Production via Targeting Hepatic Stellate Cells and Suppressing P4HA1 Expression
Background & Aims: MicroRNAs (miRNAs) have been shown to be involved in many biological processes by affecting their target gene expression. miR-122 has been extensively studied in hepatocarcinogenesis. However, a role of miR-122 in liver fibrosis remains unknown. Methods: The mRNA expression levels of miR-122, prolyl..Multidrug-Resistant Bacteria Among Patients Treated in Foreign Hospitals: Management Considerations During Medical Repatriation
Journal of Travel Medicine
Nov 2012
Multidrug-Resistant Bacteria Among Patients Treated in Foreign Hospitals: Management Considerations During Medical Repatriation
Background: The repatriation of patients from foreign hospitals can foster the emergence and spread of multidrug-resistant bacteria (MRB). We aimed to evaluate the incidence of MRB in patients treated in foreign hospitals and repatriated by international inter-hospital air transport in order to better manage these..Pharmacodynamic modelling of intravenous antibiotic prophylaxis in elective colorectal surgery
International Journal of Antimicrobial Agents
Nov 2012
Pharmacodynamic modelling of intravenous antibiotic prophylaxis in elective colorectal surgery
Surgical-site infections are the leading cause of post-operative morbidity and mortality as well as increased costs following colorectal surgery. The purpose of this study was to evaluate different β-lactam antimicrobial dosing regimens currently used for prophylaxis in elective colorectal procedures with the aim of..Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection
Journal of Infection
Nov 2012
Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection
Objectives: To analyse cytokines and chemokines from unstimulated plasma samples for detection of active TB disease, latent TB, discriminating active TB cases from latently infected contacts and for monitoring anti TB treatment. Method: We analysed ex vivo plasma samples from 33 TB patients (17 HIV negative and 16 HIV..Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment
Clinical & Experimental Allergy
Nov 2012
Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment
Background: Plasmacytoid dendritic cells (pDCs) infiltrate sites of acute Th2-dominant inflammation but their role in allergic asthma remains unclear. Objective: To characterise circulating pDCs from patients with allergic asthma outside their respective allergen season. Methods: Adhesion molecules, co-stimulatory..Predictive factors for an uncomplicated long-term course of Crohn's disease: A retrospective analysis
Journal of Crohn's and Colitis
Nov 2012
Predictive factors for an uncomplicated long-term course of Crohn's disease: A retrospective analysis
Background: Predictive factors for a mild course of Crohn's disease (CD) may have therapeutic consequences, but as yet have not been identified. Aims: To identify baseline factors that predict mild CD and design a predictive scoring system. Methods: A retrospective, multicenter study of newly diagnosed CD patients..Prognostic Values of Serum Tenascin-C in Patients with Ischaemic Heart Disease and Heart Failure
Heart, Lung and Circulation
Nov 2012
Prognostic Values of Serum Tenascin-C in Patients with Ischaemic Heart Disease and Heart Failure
Objective: The aim of this study was to evaluate the prognostic values of serum tenascin-C in patients with heart failure and ischaemic heart disease. Methods: Serum tenascin-C levels were assessed in 83 patients with heart failure and in 30 healthy subjects. The correlations between serum tenascin-C levels and left..Short Form 36-Item Health Survey test result on the empty nest elderly in China: A meta-analysis
Archives of Gerontology and Geriatrics
Nov 2012
Short Form 36-Item Health Survey test result on the empty nest elderly in China: A meta-analysis
The aim of this study was to evaluate the quality of life of the empty nest elderly in China using meta-analytic techniques. Electronic databases were searched for studies concerning the quality of life of the empty nest elderly published before December 2011. Pooled weighted mean difference (WMD) and 95% confidence..The impact of patient and tumour baseline characteristics on the overall survival of patients with advanced hepatocellular carcinoma treated with sorafenib
Digestive and Liver Disease
Nov 2012
The impact of patient and tumour baseline characteristics on the overall survival of patients with advanced hepatocellular carcinoma treated with sorafenib
Background: Impact of patient and tumour baseline characteristics on the overall survival is not well characterized in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Aims/Methods: Univariate/multivariate analyses were conducted to identify retrospectively the impact of baseline..Traditional Korean medicine practitioners’ attitudes toward evidence based medicine: A qualitative study
European Journal of Integrative Medicine
Nov 2012
Traditional Korean medicine practitioners’ attitudes toward evidence based medicine: A qualitative study
Introduction: Practitioners of complementary and alternative medicine (CAM) are willing to use EBM as guidance for their practice. Through semi-structured interviews with physicians of traditional Korean medicine (TKM), this study sought to identify the barriers to the implementation of EBM in CAM, and solutions...Updated experience with inolimomab as treatment for corticosteroid-refractory acute graft versus host disease
Biology of Blood and Marrow Transplantation
Nov 2012
Updated experience with inolimomab as treatment for corticosteroid-refractory acute graft versus host disease
Refractory acute graft-versus-host disease (aGVHD) remains an important cause of mortality after allogeneic stem cell transplantation. No standard therapy exists once steroids fail to obtain a good response. In 2006 our group published a series of patients who received inolimomab, an anti–interleukin-2 receptor..A nomogram for perioperative prognostic risk-assessment in twin–twin transfusion syndrome
Prenatal Diagnosis
Nov 2012
A nomogram for perioperative prognostic risk-assessment in twin–twin transfusion syndrome
Objective: Prognostic assessment in twin-to-twin transfusion syndrome (TTTS) is ill-defined. The objective of this study is to define a perioperative prognostic score for TTTS treated by percutaneous laser coagulation. Methods: Consecutive cases of TTTS treated by percutaneous fetoscopic laser coagulation over a 6-year..Analysis of sentinel lymph node positivity in patients with thin primary melanoma
Journal of the American Academy of Dermatology
Nov 2012
Analysis of sentinel lymph node positivity in patients with thin primary melanoma
Background: A minority of patients with T1 melanoma will have a positive sentinel lymph node (SLN) biopsy (SLNB) finding. Identifying who will develop metastatic disease is important in determining prognosis and treatment. Objective: We sought to identify clinical and histologic features predictive of a positive SLNB..Analytical goal setting in aneuploidy screening: within person biological variability of first trimester biochemical markers
Prenatal Diagnosis
Nov 2012
Analytical goal setting in aneuploidy screening: within person biological variability of first trimester biochemical markers
Objective: To determine the average within person biological variability of free-β human chorionic gonadotrophin (free hCGβ), intact hCG and pregnancy-associated plasma protein A (PAPP-A), and to establish analytical goals for the measurement of these markers when used in first trimester screening. Methods: Free hCGβ,..Anterior ECG changes following iatrogenic dissection of the right coronary artery into the aortic root: Exclusion of left coronary obstruction with transoesophageal echocardiography
Cardiovascular Revascularization Medicine
Nov 2012
Anterior ECG changes following iatrogenic dissection of the right coronary artery into the aortic root: Exclusion of left coronary obstruction with transoesophageal echocardiography
One of the most troublesome complications of percutaneous coronary intervention (PCI) or angiography is retrograde dissection of the artery into the aortic root. We report a case involving the right coronary artery (RCA) which was treated with prompt deployment of stents. Recurrent chest pain and ST segment elevation..c-Jun N-terminal kinase (JNK)-phospho-c-JUN (ser63/73) pathway is essential for FOXP3 nuclear translocation in psoriasis
Journal of Dermatological Science
Nov 2012
c-Jun N-terminal kinase (JNK)-phospho-c-JUN (ser63/73) pathway is essential for FOXP3 nuclear translocation in psoriasis
Background: In some psoriatic patients, impaired function of FOXP3+ regulatory T cells has been identified without well-uncovered mechanism(s). Meanwhile, dysregulation of FOXP3 nuclear translocation has been observed in some autoimmune syndromes and in some cancer cells. Objective: To investigate whether there is..Changes in End-Tidal Carbon Dioxide and Volumetric Carbon Dioxide as Predictors of Volume Responsiveness in Hemodynamically Unstable Patients
Journal of Cardiothoracic and Vascular Anesthesia
Nov 2012
Changes in End-Tidal Carbon Dioxide and Volumetric Carbon Dioxide as Predictors of Volume Responsiveness in Hemodynamically Unstable Patients
Objective: The purpose of this study was to determine whether changes in PETCO2 and exhaled CO2 (VCO2) can predict fluid responsiveness after a preload challenge. Design: A retrospective review of prospectively recorded data. Setting: A medical intensive care unit of a university-affiliated tertiary care hospital...Community-associated methicillin-resistant Staphylococcus aureus necrotizing pneumonia in a healthy neonate
Journal of Microbiology, Immunology and Infection
Nov 2012
Community-associated methicillin-resistant Staphylococcus aureus necrotizing pneumonia in a healthy neonate
The number of cases of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia has increased since the late 1990s, with skin and soft tissue infections predominant among neonates. Herein, we present a rare case of CA-MRSA necrotizing pneumonia with empyema following respiratory syncytial..Costs of inpatient treatment for multi-drug-resistant tuberculosis in South Africa
Tropical Medcine and International Health
Nov 2012
Costs of inpatient treatment for multi-drug-resistant tuberculosis in South Africa
Background: In South Africa, patients with multi-drug-resistant tuberculosis (MDR-TB) are hospitalised from MDR-TB treatment initiation until culture conversion. Although MDR-TB accounts for <3% of incident TB in South Africa, 55% of the public sector TB budget is spent on MDR-TB. To inform new strategies for MDR-TB..Double integration band of HTLV-1 in a young patient with infective dermatitis who developed an acute form of adult T-cell leukemia/lymphoma
Journal of Clinical Virology
Nov 2012
Double integration band of HTLV-1 in a young patient with infective dermatitis who developed an acute form of adult T-cell leukemia/lymphoma
Few cases of acute adult T-cell leukemia/lymphoma (ATL) have been diagnosed in young patients. This report is the first to describe a young girl with infective dermatitis associated with HTLV-1 that progressed to acute ATL with Southern blot hybridization and gamma-TCR-rearrangement revealing a monoclonal pattern with..Drug adherence and the incidence of coronary heart disease- and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication: A five-year cohort study
International Journal of Cardiology
Nov 2012
Drug adherence and the incidence of coronary heart disease- and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication: A five-year cohort study
Background: Randomized trials have shown that optimal adherence to antihypertensive agents could protect against cardiovascular diseases, but whether adherence reduces cardiovascular deaths in community settings has not been explored so fully. This study evaluates the association between antihypertensive adherence and..Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: Results from a nationwide survey
Journal of the American Academy of Dermatology
Nov 2012
Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: Results from a nationwide survey
Background: Detailed nationwide surveys of the epidemiologic and clinical characteristics of bullous congenital ichthyosiform erythroderma (BCIE) (novel synonym: keratinolytic ichthyosis) in a large population have not been performed previously to our knowledge. Objective: We sought to estimate the number of patients..Factors associated with female pattern hair loss and its prevalence in Taiwanese women: A community-based survey
Journal of the American Academy of Dermatology
Nov 2012
Factors associated with female pattern hair loss and its prevalence in Taiwanese women: A community-based survey
Background: Although female pattern hair loss (FPHL) has been considered simply the female counterpart of male pattern hair loss in men, the risk factors may differ. Objective: We sought to evaluate factors associated with FPHL and to estimate its prevalence in women. Method: In total, 26,226 subjects aged 30 years and..Identifying infants at high risk of peanut allergy: The Learning Early About Peanut Allergy (LEAP) screening study
Journal of Allergy and Clinical Immunology
Nov 2012
Identifying infants at high risk of peanut allergy: The Learning Early About Peanut Allergy (LEAP) screening study
Background: Peanut allergy (PA) is rare in countries in which peanuts are introduced early into infants’ diets. Learning Early About Peanut Allergy (LEAP) is an interventional study aiming to assess whether PA can be prevented by oral tolerance induction. Objective: We sought to characterize a population screened for..IL-22 suppresses IFN-γ–mediated lung inflammation in asthmatic patients
Journal of Allergy and Clinical Immunology
Nov 2012
IL-22 suppresses IFN-γ–mediated lung inflammation in asthmatic patients
Background: IL-22 controls tissue homeostasis by both proinflammatory and anti-inflammatory effects. However, the anti-inflammatory mechanisms of IL-22 remain poorly investigated. Objective: We sought to investigate the anti-inflammatory role for IL-22 in human asthma. Methods: T-cell lines derived from lung biopsy..Inequalities in HIV disease management and progression in migrants from Latin America and sub-Saharan Africa living in Spain
HIV Medicine
Nov 2012
Inequalities in HIV disease management and progression in migrants from Latin America and sub-Saharan Africa living in Spain
Objectives: The objective of the study was to analyse key HIV-related outcomes in migrants originating from Latin America and the Spanish-speaking Caribbean (LAC) or sub-Saharan Africa (SSA) living in Spain compared with native Spaniards (NSP). Methods: The Cohort of the Spanish AIDS Research Network (CoRIS) is an..Large congenital melanocytic nevi: Therapeutic management and melanoma risk: A systematic review
Journal of the American Academy of Dermatology
Nov 2012
Large congenital melanocytic nevi: Therapeutic management and melanoma risk: A systematic review
Background: Large congenital melanocytic nevi (LCMN) are defined as congenital melanocytic nevi having a projected adult size exceeding 20 cm in diameter. They occur in 1 in 20,000 to 1 in 500,000 newborns. Therapeutic management of LCMN remains controversial and is often decided according to melanoma risk. Objective:..Mammary, testicular and adnexal tuberculosis diagnosed by histology in a rural hospital in Southern Ethiopia
International Journal of Mycobacteriology
Nov 2012
Mammary, testicular and adnexal tuberculosis diagnosed by histology in a rural hospital in Southern Ethiopia
This study describes the experience of mammary, testicle and adnexal tuberculosis (TB) diagnosed by histological characteristics in a rural district hospital in Southern Ethiopia over a period of 7years. During the same period, a total of 5589 TB cases were diagnosed. Fourteen cases of breast TB with a prevalence of..Management of nonsexually acquired genital ulceration using oral and topical corticosteroids followed by doxycycline prophylaxis
Journal of the American Academy of Dermatology
Nov 2012
Management of nonsexually acquired genital ulceration using oral and topical corticosteroids followed by doxycycline prophylaxis
Background: Data regarding the treatment of nonsexually acquired genital ulceration (NSAGU) are limited. Objective: We sought to provide evidence for the safety and efficacy of topical and systemic corticosteroids followed by doxycycline prophylaxis for acute and recurrent NSAGU. Methods: A retrospective chart review..Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly
Neurobiology of Aging
Nov 2012
Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly
Poor kidney function is associated with increased risk of cognitive decline and generalized brain atrophy. Chronic kidney disease impairs glomerular filtration rate, and this deterioration is indicated by elevated blood levels of kidney biomarkers such as creatinine and cystatin C. Here we hypothesized that impaired..Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants
Clinical & Experimental Allergy
Nov 2012
Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants
Background: Culture-dependent methods have shown that meconium, the newborn's first intestinal discharge, is not sterile, but the diversity of bacteria present in this material needs to be further characterized by means of more sensitive molecular techniques. Objective: Our aims were to characterize molecularly the..Nodular melanoma: A distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia
Journal of the American Academy of Dermatology
Nov 2012
Nodular melanoma: A distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia
Background: There is a growing body of evidence that nodular melanoma (NM), because of its association with increased growth rate and thickness at diagnosis, accounts for a substantial proportion of melanoma deaths. Objective: We sought to assess the contribution of NM to melanoma deaths in comparison with other tumor..Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Leukemia Research
Nov 2012
Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Multiple myeloma (MM) is an incurable plasma cell malignancy, which causes a significant morbidity due to organ damage and bone tissue destruction. In recent years, novel drugs have become available for MM therapy thanks to a more deepened knowledge of this disease's pathogenesis. The perspective of employing targeted..Pregnancy and dermatologic therapy
Journal of the American Academy of Dermatology
Nov 2012
Pregnancy and dermatologic therapy
Dermatologists should be familiar with medication safety in pregnancy to be able to prescribe safely and confidently to pregnant women or women who may become pregnant during the course of treatment for dermatologic conditions. Topical medications should be considered first-line therapy for pregnant women, but certain..Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity
Journal of Allergy and Clinical Immunology
Nov 2012
Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity
Background: Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying physiologic and immunologic processes are not fully understood. Objective: The aim of this study was to determine whether TH9 cells develop in vivo in a model of chronic airway hyperreactivity (AHR) and what factors..Quantification of circulating CD34+/KDR+/CD45dim endothelial progenitor cells: Analytical considerations
International Journal of Cardiology
Nov 2012
Quantification of circulating CD34+/KDR+/CD45dim endothelial progenitor cells: Analytical considerations
The discovery of peripheral circulating cells that contribute to vasculogenesis and endothelial repair was one of the most fascinating breakthroughs in the domain of vascular research during the last two decades. The population of vasculogenic cells however, is heterogeneous and can be analyzed using different..Risk factors and outcomes of candida krusei bloodstream infection: a matched, case-control study
Journal of Infection
Nov 2012
Risk factors and outcomes of candida krusei bloodstream infection: a matched, case-control study
Objectives: To investigate the risk factors and outcomes associated with Candida krusei bloodstream. Methods: We performed a case control study of patients with C. krusei bloodstream infection at the University of Pennsylvania from 1982 to 2010. Controls were without candidemia, and matched to cases on duration of..Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
Journal of Allergy and Clinical Immunology
Nov 2012
Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
Background: The D-prostanoid receptor and the chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) are implicated in asthma pathogenesis. AMG 853 is a potent, selective, orally bioavailable, small-molecule dual antagonist of human D-prostanoid and CRTH2. Objective: We sought to determine the..Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution
Journal of the American Academy of Dermatology
Nov 2012
Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution
Background: Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe systemic hypersensitivity reaction caused by specific drugs, in which herpesvirus reactivations and organ dysfunction occur during the course of the disease. Although recent reports have..Skin cancer surveillance behaviors among US Hispanic adults
Journal of the American Academy of Dermatology
Nov 2012
Skin cancer surveillance behaviors among US Hispanic adults
Background: Little skin cancer prevention research has focused on the US Hispanic population. Objective: This study examined the prevalence and correlates of skin cancer surveillance behaviors among Hispanic adults. Methods: A population-based sample of 788 Hispanic adults residing in 5 southern and western states..Spring and summer eruption of the elbows: A peculiar localized variant of polymorphous light eruption
Journal of the American Academy of Dermatology
Nov 2012
Spring and summer eruption of the elbows: A peculiar localized variant of polymorphous light eruption
Background: Polymorphous light eruption (PLE) is the most common form of idiopathic photodermatosis. Several morphologic variants of PLE have been described, including a localized form of PLE primarily affecting the helices of the ears. To our knowledge, the presence of lesions on the elbows as the unique manifestation..Telbivudine in the treatment of hepatitis B-associated cryoglobulinemia
Journal of Clinical Virology
Nov 2012
Telbivudine in the treatment of hepatitis B-associated cryoglobulinemia
Background: Hepatitis C virus (HCV) infection is often associated to extrahepatic manifestations while these are less common in HBV infections. Reported cases of mixed cryoglobulinemia (MC) related to HBV infection are very rare: the exact prevalence of this extrahepatic manifestation has not yet been established and..The diagnostic efficiency of QuantiFERONTB®-Gold test in the diagnosis of tuberculous pleurisy
International Journal of Mycobacteriology
Nov 2012
The diagnostic efficiency of QuantiFERONTB®-Gold test in the diagnosis of tuberculous pleurisy
Background: Diagnosis of tuberculous pleurisy is difficult and better diagnostic tools are needed. Interferon gamma release assays (IGRAs) are in vitro immunologic diagnostic tests used to identify Mycobacterium TB infections. They cannot differentiate between latent and active infections. As IGRA tests have recently..Unknown primary Merkel cell carcinoma: 23 new cases and a review
Journal of the American Academy of Dermatology
Nov 2012
Unknown primary Merkel cell carcinoma: 23 new cases and a review
Background: Knowledge is limited regarding unknown primary Merkel cell carcinoma (UPMCC). Objective: We sought to document the characteristics and behavior of UPMCC, and determine the most appropriate treatment. Methods: A multicenter, retrospective, consecutive study reviewing patients given a diagnosis of UPMCC..Correction of first trimester biochemical aneuploidy screening markers for smoking status: influence of gestational age, maternal ethnicity and cigarette dosage
Prenatal Diagnosis
Nov 2012
Correction of first trimester biochemical aneuploidy screening markers for smoking status: influence of gestational age, maternal ethnicity and cigarette dosage
Objective: To examine the gestational age, maternal ethnicity and cigarette dosage effects of the reduction of maternal serum pregnancy-associated plasma protein A (PAPP-A) and free-β human chorionic gonadotrophin (free hCGβ) in smokers. Methods: Maternal serum PAPP-A and free hCGβ corrected for confounders, excluding..Qualitative content analysis of online news media coverage of weight loss surgery and related reader comments
Clinical Obesity
Nov 2012
Qualitative content analysis of online news media coverage of weight loss surgery and related reader comments
The media has the ability to affect public opinion and policy direction. Prevalence of morbid obesity in Canada is increasing; as is the only effective long-term treatment, weight loss surgery (WLS). Limited research has explored media re/presentations of WLS. The purpose of this study was to examine national online..Single-blind randomized controlled trial of surfactant vs hypertonic saline irrigation following endoscopic endonasal surgery
International Forum of Allergy & Rhinology
Nov 2012
Single-blind randomized controlled trial of surfactant vs hypertonic saline irrigation following endoscopic endonasal surgery
Background: Recent discussion has revolved around formulations of irrigation in the postoperative functional endoscopic sinus surgery patient, specifically the efficacy of emulsion based nasal irrigations. Methods: Forty adult candidates for endoscopic endonasal surgery with chronic rhinosinusitis (CRS) were..The effect of pre-procedure anxiety on sedative requirements for sedation during colonoscopy
Anaesthesia
Nov 2012
The effect of pre-procedure anxiety on sedative requirements for sedation during colonoscopy
This study investigated the effects of pre-procedural anxiety (assessed using the Beck Anxiety Inventory) on sedative requirements in 135 patients undergoing sedation for colonoscopy. Deep sedation was defined as loss of consciousness and no response to colonoscopy, and was achieved by target-controlled infusion of..A case of membranous nephropathy associated with relapsing polychondritis
Kidney Research and Clinical Practice
Nov 2012
A case of membranous nephropathy associated with relapsing polychondritis
Relapsing polychondritis (RP) is a rare, chronic, and potentially fatal multisystemic inflammatory disorder targeting cartilaginous structures. This disorder is frequently associated with rheumatoid arthritis, systemic vasculitis, connective tissue diseases, and hematologic disorders, but renal involvement is unusual...A gender perspective on short- and long term mortality in ST-elevation myocardial infarction — A report from the SWEDEHEART register
International Journal of Cardiology
Nov 2012
A gender perspective on short- and long term mortality in ST-elevation myocardial infarction — A report from the SWEDEHEART register
Background: Previous studies of patients admitted for ST-elevation myocardial infarction [STEMI] have indicated that women have a higher risk of early mortality than do men. These studies have presented limited information on gender related differences in the short term and almost no information on the long term...A multilevel approach for assessing the variability of hepatitis C prevalence in injection drug users by their gathering places
International Journal of Infectious Diseases
Nov 2012
A multilevel approach for assessing the variability of hepatitis C prevalence in injection drug users by their gathering places
Objectives: The aim of this study was to investigate the variation in hepatitis C virus (HCV) prevalence in injection drug users (IDUs) by their gathering places, using a multilevel approach. Methods: IDUs recruited from their gathering places were invited to respond to a questionnaire on demographics, drug use..A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol
Journal of Crohn's and Colitis
Nov 2012
A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol
Background and Aims: A skewed thiopurine metabolism is a phenomenon associated with both poor treatment response and toxicity. Our aim was to evaluate the frequency of this phenomenon and the relationship to thiopurine methyltransferase (TPMT) function. Methods: All thiopurine metabolite measurements in adult patients..Accurate assessment of load-independent right ventricular systolic function in patients with pulmonary hypertension
Heart, Lung and Circulation
Nov 2012
Accurate assessment of load-independent right ventricular systolic function in patients with pulmonary hypertension
Background: End-systolic elastance (Ees), a load-independent measure of ventricular function, is of clinical interest for studies of the right ventricle (RV) in patients with pulmonary arterial hypertension (PAH). The objective of this study was to determine whether, in PAH patients, Ees can be estimated from mean..Acute kidney injury following transcatheter aortic valve implantation: incidence, predictors and clinical outcome
International Journal of Cardiology
Nov 2012
Acute kidney injury following transcatheter aortic valve implantation: incidence, predictors and clinical outcome
Background: Limited data exist on renal complications of transcatheter aortic valve implantation (TAVI) within a comprehensive program using different valves with transfemoral, transapical, and trans-subclavian approach. Methods: Prospective single-center registry of 102 consecutive patients undergoing TAVI using both..APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease
Neurobiology of Aging
Nov 2012
APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease
APOE is the major known genetic risk factor for late-onset Alzheimer's disease. Though relationships between APOE-encoded apolipoprotein E and β-amyloid are increasingly well described, mounting evidence supports wide-ranging effects of APOE on the brain. Specifically, APOE appears to affect brain network activity and..Association of melanogenesis genes with skin color variation among Japanese females
Journal of Dermatological Science
Nov 2012
Association of melanogenesis genes with skin color variation among Japanese females
Background: Skin color mainly reflects pigmentation resulting from melanin. Although many of the detailed molecular mechanisms involved in melanin pigmentation are being revealed, little is understood about the genetic components responsible for variations in skin color within or between human populations. Objective:..Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score
American Journal of Cardiology
Nov 2012
Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score
Despite the existence of several risk scores, the accurate prediction of the prognosis in pulmonary embolism (PE) remains a challenge. The Global Registry of Acute Coronary Events (GRACE) risk score has a high diagnostic performance for adverse outcomes in acute coronary syndrome. We aimed to assess the applicability..Catheter-based renal sympathetic denervation exerts acute and chronic effects on renal hemodynamics in swine
International Journal of Cardiology
Nov 2012
Catheter-based renal sympathetic denervation exerts acute and chronic effects on renal hemodynamics in swine
Objectives: We investigated the acute and chronic effects of catheter-based renal sympathetic denervation (RSD) on renal hemodynamics assessed by average peak velocity (APV), renal blood flow (RBF), renal flow reserve (RFR) and resistive index (RI). Background: Sympathetic overdrive is accompanied by impaired RBF,..Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: Relationship with endosomal lipid trafficking genes
Journal of Psychiatric Research
Nov 2012
Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: Relationship with endosomal lipid trafficking genes
Cholesterol (CHL) and phospholipid (PL) levels in synaptosomal membranes in particular can have an impact on cell signalling. Alterations in peripheral CHL measures have been consistently reported in suicidal behaviour. As CHL and PL turnover in the brain are important in synapse maintenance and function, the objective..Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts
Journal of Dermatological Science
Nov 2012
Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts
Background: Systemic sclerosis (SSc) is a systemic inflammatory and fibrotic disease characterized by activation of circulating T lymphocytes. Objective: To determine phenotypic abnormalities of γ/δ T cells and whether γ/δ T cells influence fibroblasts activation in SSc patients. Methods: Number and proportion of..Comparison of Surgical Septal Myectomy to Medical Therapy Alone in Patients With Hypertrophic Cardiomyopathy and Syncope
American Journal of Cardiology
Nov 2012
Comparison of Surgical Septal Myectomy to Medical Therapy Alone in Patients With Hypertrophic Cardiomyopathy and Syncope
The presence of syncope despite medical therapy in patients with hypertrophic cardiomyopathy (HC) is considered an indication for surgical myectomy; however, no study has examined the long-term effects on recurrent syncope and survival after surgery in these patients. We examined 239 patients with HC and a history of..Comparisons of detailed arterial healing response at seven months following implantation of an everolimus- or sirolimus-eluting stent in patients with ST-segment elevation myocardial infarction
International Journal of Cardiology
Nov 2012
Comparisons of detailed arterial healing response at seven months following implantation of an everolimus- or sirolimus-eluting stent in patients with ST-segment elevation myocardial infarction
Background: The difference of arterial healing response following everolimus-eluting stent (EES) or sirolimus-eluting stent (SES) implantation in patients with ST-segment elevated myocardial infarction (STEMI) has not been compared in detail. Methods: Thirty-five patients with STEMI were randomly implanted with an EES..Congenital valvular aortic stenosis in young adults: Predictors for rate of progression of stenosis and aortic dilatation
International Journal of Cardiology
Nov 2012
Congenital valvular aortic stenosis in young adults: Predictors for rate of progression of stenosis and aortic dilatation
Background: Congenital aortic stenosis (AS) is the most common obstructive left-sided cardiac lesion in young adults, however little is known about the progression in adults. Therefore, we aimed to evaluate the progression rate of AS and aortic dilatation in a large multicenter retrospective cohort of asymptomatic..CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-γ-dependent autophagy
International Journal of Cardiology
Nov 2012
CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-γ-dependent autophagy
Background: Emerging evidence shows that the chemokine CXCL16 plays an important role in the pathogenesis of myocardial remodeling and development of heart failure following ischemia/reperfusion (I/R) injury. CXCR6, the receptor for CXCL16, is also critically involved. However, the underlying mechanism remained..Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
Leukemia Research
Nov 2012
Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
In vivo effects of the DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) upon the epigenome of acute myeloid leukemia (AML) patients are scarcely studied in primary blasts. Here, we sequentially assessed DNA methylation and transcriptome changes in myeloblasts of DAC-treated AML patients. DNA methylation changes..Defensive active coping facilitates chronic hyperglycaemia and endothelial dysfunction in African men: The SABPA study
International Journal of Cardiology
Nov 2012
Defensive active coping facilitates chronic hyperglycaemia and endothelial dysfunction in African men: The SABPA study
Background: Dissociation between behavioural defensive active coping (AC) control albeit physiological “loss of control” responses was associated with silent ischaemia and structural wall abnormalities in African men. Whether it applies to structural alterations and endothelial dysfunction is uncertain. We therefore..Desmin Mutations and Arrhythmogenic Right Ventricular Cardiomyopathy
American Journal of Cardiology
Nov 2012
Desmin Mutations and Arrhythmogenic Right Ventricular Cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease characterized by fibrofatty replacement of the myocardium and ventricular arrhythmias, associated with mutations in the desmosomal genes. Only a missense mutation in the DES gene coding for desmin, the intermediate filament..Determinants and clinical significance of flow via the fenestration in the Fontan pathway: A multimodality study
International Journal of Cardiology
Nov 2012
Determinants and clinical significance of flow via the fenestration in the Fontan pathway: A multimodality study
Background: The use of a fenestration in the Fontan pathway remains controversial, partly because its hemodynamic effects and clinical consequences are insufficiently understood. The objective of this study was to quantify the magnitude of fenestration flow and to characterize its hemodynamic consequences after an..Disseminated tuberculosis in a kidney transplant patient: Diagnostic significance of reversed circadian temperature rhythm
International Journal of Mycobacteriology
Nov 2012
Disseminated tuberculosis in a kidney transplant patient: Diagnostic significance of reversed circadian temperature rhythm
Presently, clinicians often forget important aspects of fever patterns. This study presents the case of disseminated tuberculosis in a 64-year-old man whose chief complaint was morning fever. He was a kidney transplant patient and presented with productive cough, reverse fever pattern and a nodular pattern in chest..Early intravenous beta-blockers in patients with acute coronary syndrome—A meta-analysis of randomized trials
International Journal of Cardiology
Nov 2012
Early intravenous beta-blockers in patients with acute coronary syndrome—A meta-analysis of randomized trials
Background: Intravenous (IV) beta-blockade is currently a Class IIa recommendation in early management of patients with acute coronary syndromes (ACS) without obvious contraindications. Methods: We searched the PubMed, EMBASE and the Cochrane Register for Controlled Clinical Trials for randomized clinical trials from..Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium
Annals of Allergy, Asthma & Immunology
Nov 2012
Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium
Background: Air pollution from road traffic is a serious public health problem. Epidemiologic studies have demonstrated adverse health effects associated with environmental pollution. Diesel exhaust is a major contributor to ambient particulate matter air pollution. We studied the effects of exposure to diesel exhaust..Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-lowering (CPC) Study
American Journal of Cardiology
Nov 2012
Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-lowering (CPC) Study
Although the effect of niacin on the glucose levels in subjects with diabetes mellitus has been investigated, niacin’s effects on the glucose levels and atherosclerosis in subjects with normal glucose levels have not been well established. We examined the effect of niacin on the glucose levels, coronary stenosis..Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-lowering (CPC) Study
American Journal of Cardiology
Nov 2012
Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-lowering (CPC) Study
Although the effect of niacin on the glucose levels in subjects with diabetes mellitus has been investigated, niacin’s effects on the glucose levels and atherosclerosis in subjects with normal glucose levels have not been well established. We examined the effect of niacin on the glucose levels, coronary stenosis..Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: Results from the COMPERA registry
International Journal of Cardiology
Nov 2012
Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: Results from the COMPERA registry
Background: Originally reported to occur predominantly in younger women, idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients. We aimed to describe the characteristics of such patients and their survival under clinical practice conditions. Methods: Prospective registry in 28..Endothelial progenitor cells in relation to endothelin-1 and endothelin receptor blockade: A randomized, controlled trial
International Journal of Cardiology
Nov 2012
Endothelial progenitor cells in relation to endothelin-1 and endothelin receptor blockade: A randomized, controlled trial
Aims: Endothelial progenitor cells (EPC) represent an endogenous repair mechanism involving rendothelialization and neoangiogenesis. Patients with both diabetes and vascular disease have low numbers of circulating EPC. The endothelium-derived peptide, endothelin-1 (ET-1), is increased in patients with type 2 diabetes..Feasibility limits of transradial primary percutaneous coronary intervention in acute myocardial infarction in the real life (TRAP-AMI)
International Journal of Cardiology
Nov 2012
Feasibility limits of transradial primary percutaneous coronary intervention in acute myocardial infarction in the real life (TRAP-AMI)
Background: There is growing evidence that transradial (TRI) as compared to transfemoral (TFI) percutaneous coronary intervention (PCI) is associated with improved clinical outcome driven by less hemorrhagic complications, in particular in STEMI patients receiving aggressive antithrombotic treatment. Feasibility rate..Five-year outcomes of surgical or percutaneous myocardial revascularization in diabetic patients
International Journal of Cardiology
Nov 2012
Five-year outcomes of surgical or percutaneous myocardial revascularization in diabetic patients
Background: The study compares five-year clinical outcomes of CABG vs PCI in a real world population of diabetic patients with multivessel coronary disease since it is not clear whether to prefer surgical or percutaneous revascularization. Methods: Between July 2002 and December 2008, 2885 multivessel coronary diabetic..Hemodialysis Access Usage Patterns in the Incident Dialysis Year and Associated Catheter-Related Complications
American Journal of Kidney Diseases
Nov 2012
Hemodialysis Access Usage Patterns in the Incident Dialysis Year and Associated Catheter-Related Complications
Background: Hemodialysis (HD) access is considered a critical and actionable determinant of morbidity, with a growing literature suggesting that initial HD access type is an important marker of long-term outcomes. Accordingly, we examined HD access during the incident dialysis period, focusing on infection risk and..Hemoglobin Stability in Patients With Anemia, CKD, and Type 2 Diabetes: An Analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) Placebo Arm
American Journal of Kidney Diseases
Nov 2012
Hemoglobin Stability in Patients With Anemia, CKD, and Type 2 Diabetes: An Analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) Placebo Arm
Background: Sparse data are available about the natural history of hemoglobin (Hb) level trends in contemporary patients with anemia, chronic kidney disease (CKD), and type 2 diabetes mellitus. We intended to describe Hb level trends over time with no or minimal administration of erythropoiesis-stimulating agents...Hoarding and the multi-faceted construct of impulsivity: A cross-cultural investigation
Journal of Psychiatric Research
Nov 2012
Hoarding and the multi-faceted construct of impulsivity: A cross-cultural investigation
The proposed hoarding disorder represents a serious psychiatric condition and considerable public health burden. Although tremendous strides have been made in understanding the phenomenology and treatment of this condition, many features regarding the etiology and nosology remain unclear. In particular, the association..How patients choose osteopaths: A mixed methods study
Complementary Therapies in Medicine
Nov 2012
How patients choose osteopaths: A mixed methods study
Objectives: To explore how patients choose individual osteopaths to consult; to test whether patients’ preferences for osteopaths depend on gender, the osteopath's qualifications, and the cost of treatment; to explore patients’ perspectives. Design: An explanatory mixed methods design incorporating a quasi-experimental..Hyperfibrinolysis diagnosed by rotational thromboelastometry in a case of suspected amniotic fluid embolism
International Journal of Obstetric Anesthesia
Nov 2012
Hyperfibrinolysis diagnosed by rotational thromboelastometry in a case of suspected amniotic fluid embolism
Rotational thromboelastometry is a viscoelastomeric, point-of-care method for testing haemostasis in whole blood which can be visualised rapidly, in real time, in the operating theatre. Advantages over traditional coagulation tests relate to the rapid feedback of results and the ability to visualise hyperfibrinolysis...Impact of gene polymorphisms of interleukin-18, transforming growth factor-β, and vascular endothelial growth factor on development of IgA nephropathy and thin glomerular basement membrane disease
Kidney Research and Clinical Practice
Nov 2012
Impact of gene polymorphisms of interleukin-18, transforming growth factor-β, and vascular endothelial growth factor on development of IgA nephropathy and thin glomerular basement membrane disease
Background: We investigated the effects of gene polymorphisms on the development of IgA nephropathy and thin glomerular basement membrane (GBM) disease by analyzing polymorphisms in the interleukin (IL)-18, transforming growth factor (TGF)-β, and vascular endothelial growth factor (VEGF) genes in Korean patients...Impaired arm development after Blalock–Taussig shunts in adults with repaired tetralogy of Fallot
International Journal of Cardiology
Nov 2012
Impaired arm development after Blalock–Taussig shunts in adults with repaired tetralogy of Fallot
Background: Many adults with repaired tetralogy of Fallot have had prior Blalock–Taussig shunts. These shunts may theoretically hinder growth and development of the ipsilateral arm. Methods: We prospectively enrolled consecutive patients with tetralogy of Fallot in a cross-sectional study to measure arm length and..In vivo and in vitro evaluation of the use of a newly developed melatonin loaded emulsion combined with UV filters as a protective agent against skin irradiation
Journal of Dermatological Science
Nov 2012
In vivo and in vitro evaluation of the use of a newly developed melatonin loaded emulsion combined with UV filters as a protective agent against skin irradiation
Background: Melatonin has attracted attention because of their high antioxidant and anticarcinogenic activity. Otherwise, the use of sunscreens is recommended for patients after chemotherapy and radiotherapy treatments or to prevent UV radiation-induced skin damages that may result in pre-cancerous and cancerous skin..Indexes of von Willebrand Factor as Biomarkers of Aortic Stenosis Severity (from the Biomarkers of Aortic Stenosis Severity [BASS] Study)
American Journal of Cardiology
Nov 2012
Indexes of von Willebrand Factor as Biomarkers of Aortic Stenosis Severity (from the Biomarkers of Aortic Stenosis Severity [BASS] Study)
We correlated von Willebrand factor (VWF) activity indexes and brain natriuretic peptide (BNP) with measures of aortic stenosis (AS) severity, bleeding, symptoms, and freedom from death or aortic valve replacement. Patients with AS (n = 66 [16 mild, 20 moderate, and 30 severe]) and aortic valve replacement (n = 21)..Indicators of domestic/intimate partner violence are structured by genetic and nonshared environmental influences
Journal of Psychiatric Research
Nov 2012
Indicators of domestic/intimate partner violence are structured by genetic and nonshared environmental influences
One of the most consistent findings to emerge from domestic/intimate partner violence (IPV) research is that IPV tends to “run in the family.” Social learning theories appear to be consistent with empirical data, but almost no attention has been given to alternative explanations, including that genetic factors explain..Influence of Gender on Ischemic Times and Outcomes After ST-Elevation Myocardial Infarction
American Journal of Cardiology
Nov 2012
Influence of Gender on Ischemic Times and Outcomes After ST-Elevation Myocardial Infarction
Previous studies investigating the influence of gender on ST-segment elevation myocardial infarction have reported conflicting results. The aim of this study was to assess the influence of gender on ischemic times and outcomes after ST-segment elevation myocardial infarction in patients treated with primary..Insufficient Deep-Colored Vegetable Intake Is Associated With Higher Fragility Fracture Rate in Postmenopausal Taiwanese Women
International Journal of Gerontology
Nov 2012
Insufficient Deep-Colored Vegetable Intake Is Associated With Higher Fragility Fracture Rate in Postmenopausal Taiwanese Women
Background: Osteoporosis-related fragility fracture is a major health issue in older adults. This study has been developed to investigate the relationship of lifestyle factors with fragility fracture prevalence in postmenopausal Taiwanese women. Methods: A total of 1050 postmenopausal women with a mean age of 66.7±8.6..Intrathecal morphine 100 and 200μg for post-cesarean delivery analgesia: a trade-off between analgesic efficacy and side effects
International Journal of Obstetric Anesthesia
Nov 2012
Intrathecal morphine 100 and 200μg for post-cesarean delivery analgesia: a trade-off between analgesic efficacy and side effects
Introduction: Intrathecal morphine is highly effective for post-cesarean analgesia; however, the optimal dose is yet to be established. The aim of this study was to compare analgesia and side effects after a change in institutional practice to give 200μg rather than 100μg. Methods: We conducted a retrospective chart..Intravascular ultrasound assessed incomplete stent apposition and stent fracture in stent thrombosis after bare metal versus drug-eluting stent treatment the Nordic Intravascular Ultrasound Study (NIVUS)
International Journal of Cardiology
Nov 2012
Intravascular ultrasound assessed incomplete stent apposition and stent fracture in stent thrombosis after bare metal versus drug-eluting stent treatment the Nordic Intravascular Ultrasound Study (NIVUS)
Background: This prospective multicenter registry used intravascular ultrasound (IVUS) in patients with definite stent thrombosis (ST) to compare rates of incomplete stent apposition (ISA), stent fracture and stent expansion in patients treated with drug-eluting (DES) versus bare metal (BMS) stents. ST is a rare, but..Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
Neurobiology of Aging
Nov 2012
Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
Recent evidence from cross-sectional in vivo imaging studies suggests that atrophy of the cholinergic basal forebrain (BF) in Alzheimer's disease (AD) can be distinguished from normal age-related degeneration even at predementia stages of the disease. Longitudinal study designs are needed to specify the dynamics of BF..Lower cognitive reserve in the aging human immunodeficiency virus-infected brain
Neurobiology of Aging
Nov 2012
Lower cognitive reserve in the aging human immunodeficiency virus-infected brain
More HIV-infected individuals are living longer; however, how their brain function is affected by aging is not well understood. One hundred twenty-two men (56 seronegative control [SN] subjects, 37 HIV subjects with normal cognition [HIV+NC], 29 with HIV-associated neurocognitive disorder [HAND]) performed..Management of neck metastases in T2N0 lip squamous cell carcinoma
American Journal of Otolaryngology
Nov 2012
Management of neck metastases in T2N0 lip squamous cell carcinoma
Background: Prophylactic neck dissection (PND) is indicated when the chance of occult lymph node metastases from head and neck tumors is significant. There is no consensus regarding which tumor size PND would be indicated in cases of lip cancer. Methods: A total of 139 patients with surgically treated lip cancer were..Matrix metalloproteinase-12 contributes to neuroinflammation in the aged brain
Neurobiology of Aging
Nov 2012
Matrix metalloproteinase-12 contributes to neuroinflammation in the aged brain
During aging the brain displays an increased proinflammatory status, which is associated with the pathogenesis of aging-related diseases such as Alzheimer's and Parkinson diseases. Matrix metalloproteinases (MMPs) facilitate the migration of inflammatory cells in tissues and modulate their inflammatory activity. In..Muscle strength is the main associated factor of physical performance in older adults with knee osteoarthritis regardless of radiographic severity
Archives of Gerontology and Geriatrics
Nov 2012
Muscle strength is the main associated factor of physical performance in older adults with knee osteoarthritis regardless of radiographic severity
The aim of the study is to compare factors associated with physical performance in older individuals with severe knee osteoarthritis and those with less-severe osteoarthritis. This is an ancillary cross-sectional study to a population-based cohort study focusing on Koreans age 65 years or older. The analysis included..Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update
Journal of Dermatological Science
Nov 2012
Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update
Human hair disorders comprise a number of different types of alopecia, atrichia, hypotrichosis, distinct hair shaft disorders as well as hirsutism and hypertrichosis. Their causes vary from genodermatoses (e.g. hypotrichoses) via immunological disorders (e.g. alopecia areata, autoimmune cicatrical alopecias) to..Orally bioavailable small molecule drug protects memory in Alzheimer's disease models
Neurobiology of Aging
Nov 2012
Orally bioavailable small molecule drug protects memory in Alzheimer's disease models
Oligomers of beta-amyloid (Aβ) are implicated in the early memory impairment seen in Alzheimer's disease before to the onset of discernable neurodegeneration. Here, the capacity of a novel orally bioavailable, central nervous system-penetrating small molecule 5-aryloxypyrimidine, SEN1500, to prevent cell-derived (7PA2..Patients with low compared with high body mass index gain more weight after implantation of a continuous-flow left ventricular assist device
Heart, Lung and Circulation
Nov 2012
Patients with low compared with high body mass index gain more weight after implantation of a continuous-flow left ventricular assist device
Background: Patterns of weight change after implantation of a continuous-flow left ventricular assist device (CF-LVAD) can affect transplant candidacy and may influence outcomes. We evaluated changes in weight over a 24-month period from a national LVAD clinical trial database. Methods: A retrospective analysis was..Pilot Study of Comprehensive Geriatric Assessment (CGA) In Allogeneic Transplant: CGA Captures a High Prevalence of Vulnerabilities in Older Transplant Recipients
Biology of Blood and Marrow Transplantation
Nov 2012
Pilot Study of Comprehensive Geriatric Assessment (CGA) In Allogeneic Transplant: CGA Captures a High Prevalence of Vulnerabilities in Older Transplant Recipients
Comprehensive geriatric assessment (CGA) is frequently used in oncology to measure the health status of older adults with cancer, but it has not been studied in allogeneic hematopoietic cell transplantation (HCT). We conducted a prospective pilot study of CGA in allogeneic HCT recipients aged ≥50 years to examine the..Population trends and inequalities in incidence and short-term outcome of acute myocardial infarction between 1998 and 2007
International Journal of Cardiology
Nov 2012
Population trends and inequalities in incidence and short-term outcome of acute myocardial infarction between 1998 and 2007
Objective: We studied time trends in acute myocardial infarction (AMI) incidence, including out-of-hospital mortality proportions and hospitalized case-fatality rates. In addition, we compared AMI trends by age, gender and socioeconomic status. Methods: We linked the national Dutch hospital discharge register with the..Potentially important considerations in choosing specific statin treatments to reduce overall morbidity and mortality
International Journal of Cardiology
Nov 2012
Potentially important considerations in choosing specific statin treatments to reduce overall morbidity and mortality
Hypercholesterolemia and dyslipidemia are independent risk factors for cardiovascular disease and death. Statins are the drugs of choice to decrease plasma cholesterol and have other beneficial actions beyond lipid-lowering leading to substantial improvements in cardiovascular morbidity and mortality. However,..Pulmonary Hypertension in CKD
American Journal of Kidney Diseases
Nov 2012
Pulmonary Hypertension in CKD
Pulmonary arterial hypertension is a rare disease often associated with positive antinuclear antibody and high mortality. Pulmonary hypertension, which rarely is severe, occurs frequently in patients with chronic kidney disease (CKD). The prevalence of pulmonary hypertension ranges from 9%-39% in individuals with stage..QiShenYiQi Pills® prevents cardiac ischemia–reperfusion injury via energy modulation
International Journal of Cardiology
Nov 2012
QiShenYiQi Pills® prevents cardiac ischemia–reperfusion injury via energy modulation
Background: QiShenYiQi Pills® (QSYQ) is a compound Chinese medicine used in China for alleviating cardiac function. The present study was designed to explore the effect and mechanism of QSYQ on ischemia–reperfusion (I/R)-induced disorders in myocardial structure and function, with particularly focusing on the..Real Incidence of Diabetes Mellitus in a Coronary Disease Population
American Journal of Cardiology
Nov 2012
Real Incidence of Diabetes Mellitus in a Coronary Disease Population
The high prevalence of unknown diabetes mellitus (DM) in patients with coronary disease and that the oral glucose tolerance test (OGTT) is the best diagnostic method in this context are well known. However, data about the incidence of DM in this population have not been well described. In the present study, we sought..Refining the Role of Antiplatelet Therapy in Medically Managed Patients With Acute Coronary Syndrome
American Journal of Cardiology
Nov 2012
Refining the Role of Antiplatelet Therapy in Medically Managed Patients With Acute Coronary Syndrome
Dual-antiplatelet therapy with aspirin plus a P2Y12 receptor inhibitor is recommended for use as first-line therapy in patients with acute coronary syndromes (ACS) who undergo high-risk percutaneous coronary intervention. However, revascularization may not be a beneficial option for some subgroups of patients with ACS...Relation of Morbid Obesity and Female Gender to Risk of Procedural Complications in Patients Undergoing Atrial Fibrillation Ablation
American Journal of Cardiology
Nov 2012
Relation of Morbid Obesity and Female Gender to Risk of Procedural Complications in Patients Undergoing Atrial Fibrillation Ablation
Obese patients with atrial fibrillation (AF) are frequently treated with AF ablation. We sought to examine whether a body mass index (BMI) threshold exists beyond which the odds of experiencing a complication from AF ablation increases. All patients enrolled in the Vanderbilt AF Registry who underwent catheter-based AF..Relation of Vitamin D and Parathyroid Hormone to Cardiac Biomarkers and to Left Ventricular Mass (from the Cardiovascular Health Study)
American Journal of Cardiology
Nov 2012
Relation of Vitamin D and Parathyroid Hormone to Cardiac Biomarkers and to Left Ventricular Mass (from the Cardiovascular Health Study)
Vitamin D and parathyroid hormone (PTH) may affect cardiovascular health in patients with kidney disease and in the general population. The aim of this study was to investigate associations of serum 25-hydroxyvitamin D (25(OH)D) and PTH concentrations with a comprehensive set of biochemical, electrocardiographic, and..Response of infantile airway and facial hemangiomas to propranolol in a patient with PHACE syndrome
International Journal of Pediatric Otorhinolaryngology Extra
Nov 2012
Response of infantile airway and facial hemangiomas to propranolol in a patient with PHACE syndrome
PHACE syndrome is a neurocutaneous syndrome defined by posterior fossa malformations (P), hemangiomas (H), arterial anomalies (A), cardiac defects and coarctation of the aorta (C), and eye abnormalities (E). Propranolol is currently first line therapy for treatment of head and neck hemangiomas that cause functional..Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease
Journal of Crohn's and Colitis
Nov 2012
Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease
Background: Metabolic risk factors are associated with non-alcoholic fatty liver disease (NAFLD), but they are less frequent in inflammatory bowel disease (IBD). Aim: This study evaluates the frequency of NAFLD and its risk factors among IBD patients including anti-TNF-α therapy. Methods: IBD patients who underwent..Secondary salutogenic effects in veterans whose parents were Holocaust survivors?
Journal of Psychiatric Research
Nov 2012
Secondary salutogenic effects in veterans whose parents were Holocaust survivors?
Addressing the ongoing controversy over inter-generational transmission of trauma, we examined the impact of the Nazi Holocaust on PTSD course and co-morbid symptoms (e.g., depression, anxiety) among offspring of survivors following their own adversity in two longitudinal studies. Two samples of Israeli war veterans..Successful Treatment by Transcatheter Aortic Valve Implantation of Severe Aortic Regurgitation in a Patient with Ascending Aorta Prosthesis
Heart, Lung and Circulation
Nov 2012
Successful Treatment by Transcatheter Aortic Valve Implantation of Severe Aortic Regurgitation in a Patient with Ascending Aorta Prosthesis
Severe aortic regurgitation (AR), when intervention is required, is managed by surgical aortic valve replacement (SAVR). Recently, transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS) has shown non-inferiority to SAVR and superiority to medical management. TAVR could be a valid “off label”..Symptomatic duodenal Crohn's disease: Is strictureplasty the right choice?
Journal of Crohn's and Colitis
Nov 2012
Symptomatic duodenal Crohn's disease: Is strictureplasty the right choice?
Primary duodenal localization of Crohn's disease (CD) is rare. Medical therapy can control symptoms, but surgery is required when progressive obstructive symptoms occur. Surgical options include bypass, resection, or strictureplasty, but it is still not clear which should be the treatment of choice. Reviewing the..Temporal Trends in Medical Therapies for ST- and Non-ST Elevation Myocardial Infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study)
American Journal of Cardiology
Nov 2012
Temporal Trends in Medical Therapies for ST- and Non-ST Elevation Myocardial Infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study)
Reports from large studies using administrative data sets and event registries have characterized recent temporal trends and treatment patterns for acute myocardial infarction. However, few were population based, and fewer examined differences in patterns of treatment for patients presenting with ST-segment elevation..The changing pattern of bacterial meningitis in adult patients at a large tertiary university hospital in Barcelona, Spain (1982 - 2010)
Journal of Infection
Nov 2012
The changing pattern of bacterial meningitis in adult patients at a large tertiary university hospital in Barcelona, Spain (1982 - 2010)
Background: We conducted a prospective, observational study in Barcelona (Spain) to determine changes in the spectrum of adult patients with bacterial meningitis (BM) over a 29-year period. Methods: The observation was divided into two periods: 1982–1995 (I) and 1996–2010 (II). All patients underwent clinical..The identification of potentially pathogenic and therapeutic epitopes from common human allergens
Annals of Allergy, Asthma & Immunology
Nov 2012
The identification of potentially pathogenic and therapeutic epitopes from common human allergens
Objectives: To outline the processes involved in large-scale T-cell epitope identification from common allergens and illustrate their relevance to development of allergy specific immunotherapy. Data Sources: A set of studies recently published by our laboratory illustrating high-throughput identification of allergen..The predictive validity of Expressed Emotions (EE) in schizophrenia. A 20-year prospective study
Journal of Psychiatric Research
Nov 2012
The predictive validity of Expressed Emotions (EE) in schizophrenia. A 20-year prospective study
Background: The level of expressed emotions in the family (EE) and components thereof (emotional over-involvement EOI, and critical comments CC) have been found to be related to treatment outcomes in psychotic patients. One point of interest is the dynamic of various outcomes in relation to initial EE, CC and EOI..The prognosis of periprocedural myocardial infarction after percutaneous coronary interventions
Cardiovascular Revascularization Medicine
Nov 2012
The prognosis of periprocedural myocardial infarction after percutaneous coronary interventions
An increase of biomarkers of myocardial necrosis is observed frequently after percutaneous coronary interventions (PCI) even when the procedure seems angiographically successful and otherwise uncomplicated. The recently updated Universal Definition of Myocardial infarction (MI) arbitrarily defined periprocedural MI..The role of the mycobiome in human acute graft-versus-host disease
Biology of Blood and Marrow Transplantation
Nov 2012
The role of the mycobiome in human acute graft-versus-host disease
A role for gut bacteria in the pathogenesis of graft-versus-host disease (GVHD) has been firmly established; however, the role of Candida spp, which form part of the mycobiome, remains unknown. In a homogenous group of patients who underwent allogeneic stem cell transplantation (SCT), we found a significant impact of..Thigh circumference and low ankle brachial index in US adults: Results from the National Health and Nutrition Examination Survey 1999–2004
International Journal of Cardiology
Nov 2012
Thigh circumference and low ankle brachial index in US adults: Results from the National Health and Nutrition Examination Survey 1999–2004
Objective: Recent studies have suggested that smaller thighs are a disadvantage for health and survival, but the association of thigh circumference with atherosclerosis remains uncertain. The purpose of this study was to investigate the association between thigh circumference and peripheral arterial disease (PAD), as..Treosulfan-Thiotepa-Fludarabine based Conditioning Regimen for Allogeneic Transplantation in patients with Thalassaemia Major: A Single Centre Experience from North India
Biology of Blood and Marrow Transplantation
Nov 2012
Treosulfan-Thiotepa-Fludarabine based Conditioning Regimen for Allogeneic Transplantation in patients with Thalassaemia Major: A Single Centre Experience from North India
Hematopoietic stem cell transplantation (HSCT) is the definite treatment for thalassemia major. A busulfan (Bu) and cyclophosphamide (Cy)–based regimen has been the standard myeloablative chemotherapy, but is associated with higher treatment-related toxicity, particularly in patients classified as high risk by the..Tuberculosis Skin Test, but not Interferon-γ-releasing assays is affected by BCG Vaccination in HIV patients
Journal of Infection
Nov 2012
Tuberculosis Skin Test, but not Interferon-γ-releasing assays is affected by BCG Vaccination in HIV patients
Objective: Of this study was to compare the results of tuberculin skin test (TST) with two interferon-γ releasing-assays (IGRA) in a cohort of HIV positive patients, to analyze impact of prior Bacille-Calmette–Guérin (BCG)-vaccination. Methods: Prospective cross sectional study, enrolling only asymptomatic adult HIV..Validation of contemporary stroke and bleeding risk stratification scores in non-anticoagulated Chinese patients with atrial fibrillation
International Journal of Cardiology
Nov 2012
Validation of contemporary stroke and bleeding risk stratification scores in non-anticoagulated Chinese patients with atrial fibrillation
Background: Risk stratification schemes assessing stroke and thromboembolism (stroke/TE) and bleeding relating to atrial fibrillation (AF) have largely been derived and validated in Western populations. We assessed risk factors that constitute scores for assessing stroke/TE (CHADS2, CHA2DS2-VASc) and bleeding..Women hospitalized with atrial fibrillation: Gender differences, trends and outcome from a 20-year registry in a middle eastern country (1991–2010)
International Journal of Cardiology
Nov 2012
Women hospitalized with atrial fibrillation: Gender differences, trends and outcome from a 20-year registry in a middle eastern country (1991–2010)
Background: Most of the published research on atrial fibrillation (AF) is limited to studies in the developed world and included mainly Caucasian patients. Data about women with AF among other ethnicities is very limited. Objectives: The aim of this study was to compare the clinical characteristics, treatment and..A bedside communication tool did not improve the alignment of a multidisciplinary team's goals for intensive care unit patients
Journal of Critical Care
Nov 2012
A bedside communication tool did not improve the alignment of a multidisciplinary team's goals for intensive care unit patients
Purpose: Establishing well-understood daily patient care goals should improve healthcare team (HCT) communication, reduce errors, and improve patient outcomes. The purpose of this study was to test the hypothesis that implementation of a daily goals “Door Communication Card” (DCC) would improve goal alignment between..A comparison of the rapid shallow breathing index and complexity measures during spontaneous breathing trials after cardiac surgery
Journal of Critical Care
Nov 2012
A comparison of the rapid shallow breathing index and complexity measures during spontaneous breathing trials after cardiac surgery
Purpose: Extubation failure is associated with worse outcomes. Physicians use respiratory parameters to help them to decide to extubate or not. The purpose of this study is to determine if novel measures of respiratory physiology such as complexity and variability can identify patients who will tolerate extubation...A conceptual approach to improving care in pandemics and beyond: Severe lung injury centers
Journal of Critical Care
Nov 2012
A conceptual approach to improving care in pandemics and beyond: Severe lung injury centers
The events of the 2009 influenza pandemic sparked discussion regarding the need to optimize delivery of care to those most severely ill. We propose in this conceptual study that a tiered regionalization care system be instituted for patients with severe acute respiratory distress syndrome. Such system would be a..Abdominal Compartment Syndrome and Acute Kidney Injury Due to Excessive Auto–Positive End-Expiratory Pressure
American Journal of Kidney Diseases
Nov 2012
Abdominal Compartment Syndrome and Acute Kidney Injury Due to Excessive Auto–Positive End-Expiratory Pressure
Abdominal compartment syndrome is an under-recognized cause of acute kidney injury in critically ill patients. We report a case of a patient with severe obstructive lung disease who, while intubated for respiratory failure, developed abdominal compartment syndrome and oliguric acute kidney injury due to air-trapping..Antipyretic therapy in febrile critically ill adults: A systematic review and meta-analysis
Journal of Critical Care
Nov 2012
Antipyretic therapy in febrile critically ill adults: A systematic review and meta-analysis
Purpose: To determine whether fever control with antipyretic therapy effects the mortality of febrile critically ill adults. Methods: Systematic review using MEDLINE, EMBASE, Cochrane Central Register for Controlled Trials, CINAHL, Google Scholar, and 2 clinical trial registries from inception to April 2012. Randomized..Asthma severity in childhood and metabolomic profiling of breath condensate
Allergy
Nov 2012
Asthma severity in childhood and metabolomic profiling of breath condensate
Background: Asthma is a heterogeneous disease and its different phenotypes need to be better characterized from a biochemical-inflammatory standpoint. This study aimed to apply the metabolomic approach to exhaled breath condensate (breathomics) to discriminate different asthma phenotypes, with a particular focus on..Beneficial effect of splenic artery ligation on bacterial translocation after major liver resection in rats
Digestive and Liver Disease
Nov 2012
Beneficial effect of splenic artery ligation on bacterial translocation after major liver resection in rats
Objective: In major liver resection, bacterial translocation appears to be an important mechanism in the pathogenesis of spontaneous infection. This study was designed to investigate the effects of splenic artery ligation on bacterial translocation after major liver resection. Materials and methods: Rats were divided..C-reactive protein induces expression of matrix metalloproteinase-9: A possible link between inflammation and plaque rupture
International Journal of Cardiology
Nov 2012
C-reactive protein induces expression of matrix metalloproteinase-9: A possible link between inflammation and plaque rupture
Background: Matrix metalloproteases (MMPs) have been implicated in the pathogenesis of acute coronary syndromes (ACS). However, little is known about the mechanisms responsible for MMP expression in ACS. C-reactive protein (CRP) not only is an independent risk factor for cardiovascular events, but also may exert direct..Cardiac output responses in a flow-driven protocol of resuscitation following cardiac surgery
Journal of Critical Care
Nov 2012
Cardiac output responses in a flow-driven protocol of resuscitation following cardiac surgery
Objective: Determine the role of cardiac output and central venous pressure (CVP) measurements in the clinical decisions that were based on the algorithm used in a randomized trial that compared a colloid to a crystalloid solution in the management of patients early after cardiac surgery (FACS trial, NCT00337805, Crit..Cerebral desaturation events in the intensive care unit following cardiac surgery
Journal of Critical Care
Nov 2012
Cerebral desaturation events in the intensive care unit following cardiac surgery
Purpose: Patients may be at high risk for hemodynamic instability in the early postoperative period, with subsequent poor cerebral perfusion and the development of postoperative cerebral oxygen desaturation events (CDEs). Intraoperative CDEs have been associated with postoperative adverse events. However, none of these..Cerebral herniation associated with central venous catheter insertion: Risk assessment
Journal of Critical Care
Nov 2012
Cerebral herniation associated with central venous catheter insertion: Risk assessment
Purpose: Central venous catheters (CVCs) are often necessary to treat acute brain-injured patients. Four cases of cerebral herniation immediately following central venous catheterization were the impetus for an investigation of clinical and radiologic parameters associated with this complication. Materials and Methods:..Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Journal of Allergy and Clinical Immunology
Nov 2012
Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Background: Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis. Objectives: We sought to gather clinical data of IL-10/IL-10R–deficient patients and devise guidelines for diagnosis and management, including hematopoietic stem cell..Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: A prospective study
Journal of Critical Care
Nov 2012
Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: A prospective study
Purpose: The aim of this study was to assess associations between consecutive thrombelastography (TEG) profiles and standard coagulation tests and disease severity and mortality in patients with severe sepsis. Materials and Methods: This was a prospective observational study of adults with severe sepsis admitted to the..Contributions of tele–intensive care unit (Tele-ICU) technology to quality of care and patient safety
Journal of Critical Care
Nov 2012
Contributions of tele–intensive care unit (Tele-ICU) technology to quality of care and patient safety
The deployment of remote monitoring of intensive care unit (ICU) patients, known as tele-ICU technology, promotes the efficient use of critical care resources. Although tele-ICU use has spread rapidly, the benefits vary widely among studies, and little is known about the specific characteristics of tele-ICU that..Delirium assessment using Confusion Assessment Method for the Intensive Care Unit in Chinese critically ill patients
Journal of Critical Care
Nov 2012
Delirium assessment using Confusion Assessment Method for the Intensive Care Unit in Chinese critically ill patients
Purpose: The aim of this study was to provide a method for delirium evaluation in simplified Chinese for patients speaking this language via validation of a translation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Materials and Methods: Two phases were conducted including initial..Effect of Early Initiation of Dialysis on Cardiac Structure and Function: Results From the Echo Substudy of the IDEAL Trial
American Journal of Kidney Diseases
Nov 2012
Effect of Early Initiation of Dialysis on Cardiac Structure and Function: Results From the Echo Substudy of the IDEAL Trial
Background: Abnormalities of cardiac structure and function are common in patients undergoing dialysis, and cardiovascular disease is the major cause of mortality in this group. Heart failure is a common clinical manifestation of cardiovascular disease and is preceded by left ventricular hypertrophy (LVH). There are..Effects of Sodium Intake and Diet on Racial Differences in Urinary Potassium Excretion: Results From the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial
American Journal of Kidney Diseases
Nov 2012
Effects of Sodium Intake and Diet on Racial Differences in Urinary Potassium Excretion: Results From the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial
Background: We previously showed that African Americans excreted less urinary potassium than whites, even while consuming similar diets in the Dietary Approaches to Stop Hypertension (DASH) trial. We hypothesized that a low-sodium diet may eliminate these differences. Study Design: Data from the DASH-Sodium randomized..Evaluation of agreement between clinical and histopathological data for classifying leprosy
International Journal of Infectious Diseases
Nov 2012
Evaluation of agreement between clinical and histopathological data for classifying leprosy
Background: The diversity of clinical manifestations of leprosy has given rise to different classification systems. However, there are important differences in the sensitivity and specificity of these classifications. The objective of this study was to evaluate the agreement between clinical and histopathological data..Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns
Allergy
Nov 2012
Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns
Background: The remodeling patterns in different types of chronic rhinosinusitis (CRS) have rarely been compared, particularly the difference between eosinophilic and noneosinophilic CRS with nasal polyps (CRSwNP). Moreover, whether there is a link between remodeling and inflammation remains controversial. Objective:..Futility Rules for Telaprevir Combination Treatment for Patients with Hepatitis C Virus Infection
Clinical Gastroenterology and Hepatology
Nov 2012
Futility Rules for Telaprevir Combination Treatment for Patients with Hepatitis C Virus Infection
For patients treated with telaprevir, peginterferon, and ribavirin, futility rules have been developed to prevent needless drug exposure and minimize development of drug-resistant variants for patients who have little or no chance of achieving a sustained virologic response. We performed retrospective analyses of data..Impact of serum C-reactive protein measurements in the first 2 days on the 30-day mortality in hospitalized patients with severe community-acquired pneumonia: A cohort study
Journal of Critical Care
Nov 2012
Impact of serum C-reactive protein measurements in the first 2 days on the 30-day mortality in hospitalized patients with severe community-acquired pneumonia: A cohort study
Introduction: The purpose of the study is to evaluate the impact of daily consecutive measurements of C-reactive protein (CRP) in the initial 2 days of hospitalization on the 30-day all-cause mortality in patients with severe community-acquired pneumonia (CAP). Methods: We used 4 different thresholds of fractional..MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells
Journal of Dermatological Science
Nov 2012
MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells
Background: MiRNAs remain at a constant level under physiological conditions. However, how the expression of miRNAs is regulated and what are the roles of miRNAs in response to UVB damage to skin cells is still not fully understood. In our preliminary study, we observed that miR-23a was upregulated following a..Molecular analysis of the carbapenem and metronidazole resistance mechanisms of Bacteroides strains reported in a Europe-wide antibiotic resistance survey
International Journal of Antimicrobial Agents
Nov 2012
Molecular analysis of the carbapenem and metronidazole resistance mechanisms of Bacteroides strains reported in a Europe-wide antibiotic resistance survey
Here we examine the carbapenem and metronidazole resistance mechanisms of 640 Bacteroides strains reported in the 2008–2009 European antibiotic susceptibility survey. Of the 22 strains with elevated imipenem minimum inhibitory concentrations (≥4μg/mL), 10 were cfiA-positive and out of these 5 carried activating..Motivation and job satisfaction of Tele-ICU nurses
Journal of Critical Care
Nov 2012
Motivation and job satisfaction of Tele-ICU nurses
Introduction: Although the first tele-ICU has been in existence for more than 12 years, little is known about the work of tele-ICU nurses. This study examines sources of motivation and satisfaction of tele-ICU nurses. Methods: A total of 50 nurses in 5 tele-ICUs were interviewed about reasons for working as a tele-ICU..Outbreak of skin and soft tissue infections in a hospital newborn nursery in Italy due to community-acquired meticillin-resistant Staphylococcus aureus USA300 clone
Journal of Hospital Infection
Nov 2012
Outbreak of skin and soft tissue infections in a hospital newborn nursery in Italy due to community-acquired meticillin-resistant Staphylococcus aureus USA300 clone
Background: Community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) is responsible for severe infections in previously healthy people acquired in the community in different areas of the world. Aim: To report an outbreak of CA-MRSA in a hospital newborn nursery in northern Italy in September–October..Residual risk of cardiovascular mortality in patients with coronary heart disease: The EUROASPIRE Risk Categories
International Journal of Cardiology
Nov 2012
Residual risk of cardiovascular mortality in patients with coronary heart disease: The EUROASPIRE Risk Categories
Background: The EUROASPIRE I, II and III surveys revealed high prevalences of modifiable risk factors in the high priority group of coronary patients all over Europe. The potential to further reduce coronary heart disease (CHD) morbidity and mortality rates is still considerable. We report here on the relative risk of..Ribotyping in the detection of Clostridium difficile outbreaks in a single university hospital
Journal of Hospital Infection
Nov 2012
Ribotyping in the detection of Clostridium difficile outbreaks in a single university hospital
Clostridium difficile infection (CDI) is the most important bacterial cause of hospital-acquired diarrhoea. Although reports of deaths associated with CDI have been decreasing since a peak in 2007 in England and Northern Ireland, it remains a major cause of morbidity and mortality. The Health Protection..Risk of in-hospital mortality identified according to the typology of patients with acute heart failure: Classification tree analysis on data from the Acute Heart Failure Database–Main registry
Journal of Critical Care
Nov 2012
Risk of in-hospital mortality identified according to the typology of patients with acute heart failure: Classification tree analysis on data from the Acute Heart Failure Database–Main registry
Purpose: The purposes of this study are to identify the strongest clinical parameters in relation to in-hospital mortality, which are available in the earliest phase of the hospitalization of patients, and to create an easy tool for the early identification of patients at risk. Materials and Methods: The classification..Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study
Journal of Critical Care
Nov 2012
Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study
Purpose: Determine whether there are unique patterns to the urine biochemistry profile in septic compared with non-septic acute kidney injury (AKI) and whether urinary biochemistry predicts worsening AKI, need for renal replacement therapy and mortality. Materials and Methods: Prospective cohort study of critically ill..A case of necrotizing sialometaplasia involving bilateral parotid glands
American Journal of Otolaryngology
Nov 2012
A case of necrotizing sialometaplasia involving bilateral parotid glands
Necrotizing sialometaplasia of the parotid gland is infrequent and can be mistaken as a malignant disease. Its etiology is thought to be an insufficient blood supply. Bilateral involvement of this disease in parotid glands has been rarely reported in the English literature. We report a case of necrotizing..A randomised comparison of InnoScope and Macintosh laryngoscope in simulated difficult tracheal intubation in manikins
Anaesthesia
Nov 2012
A randomised comparison of InnoScope and Macintosh laryngoscope in simulated difficult tracheal intubation in manikins
We conducted a crossover randomised study to evaluate the performance of a novel optical stylet, the InnoScope, for tracheal intubation in simulated normal and difficult airways. Twenty-five anaesthetists attempted tracheal intubation on a SimMan 3G simulator using the InnoScope first followed by the Macintosh..Anaphylaxis from ingestion of mites: Pancake anaphylaxis
Journal of Allergy and Clinical Immunology
Nov 2012
Anaphylaxis from ingestion of mites: Pancake anaphylaxis
Oral mite anaphylaxis is a new syndrome characterized by severe allergic symptoms occurring immediately after eating foods made with mite-contaminated wheat flour. This syndrome, which is more prevalent in tropical environments, is triggered more often by pancakes, and for that reason, it has been designated “the..Blood glucose levels in children with Type 1 diabetes attending a residential diabetes camp: a 2-year review
Diabetic Medicine
Nov 2012
Blood glucose levels in children with Type 1 diabetes attending a residential diabetes camp: a 2-year review
Aims: The objective of this retrospective analysis of blood glucose values at a week-long residential summer camp for children with Type 1 diabetes was to provide experiential data to reinforce current summer camp guidelines and to determine if specific interventions implemented between 2009 and 2010 were effective in..Cardioprotective molecules are enriched in beating cardiomyocytes derived from human embryonic stem cells
International Journal of Cardiology
Nov 2012
Cardioprotective molecules are enriched in beating cardiomyocytes derived from human embryonic stem cells
Background: Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) have attracted attention because of their cardiac regenerative potential in vivo. Differentiated CMs can be distinguished into two different phenotypic populations: beating and non-beating CMs. A thorough understanding of the different..Characterizing the transition from paediatric to adult care among emerging adults with Type 1 diabetes
Diabetic Medicine
Nov 2012
Characterizing the transition from paediatric to adult care among emerging adults with Type 1 diabetes
Aims: The goals of the study were to describe the transition of youth with Type 1 diabetes from paediatric to adult healthcare services, examine the link of this transition with self care and glycaemic control, and distinguish youth who received medical treatment from different physicians in terms of demographic and..Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility
Clinical & Experimental Allergy
Nov 2012
Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility
Background: Genetic studies have identified numerous genes reproducibly associated with asthma, yet these studies have focused almost entirely on single nucleotide polymorphisms (SNPs), and virtually ignored another highly prevalent form of genetic variation: Copy Number Variants (CNVs). Objective: To survey the..Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation
International Journal of Cardiology
Nov 2012
Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation
Background: Hyperglycemia is an important risk factor for cardiovascular diseases no matter if it resulted from type I or type II diabetes mellitus. High glucose-induced generation of reactive oxygen species (ROS) can lead to diabetic cardiomyopathy. In our previous study, we showed that NADPH oxidase-related..Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer’s disease
Neurobiology of Aging
Nov 2012
Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer’s disease
Previously, we reported a Ca2+/calmodulin (CaM)-dependent impairment of apoptosis induced by serum deprivation in Alzheimer’s disease (AD) lymphoblasts. These cell lines showed downregulation of extracellular signal-regulated kinase (ERK)1/2 activity and elevated content of p21 compared with control cells. The aim of..EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria
Allergy
Nov 2012
EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria
An autoimmune subset of chronic spontaneous urticaria is increasingly being recognized internationally, based on laboratory and clinical evidence that has accrued over the last 20 years. This evidence has been reviewed by a taskforce of the Dermatology section of the European Academy of Allergy and Clinical Immunology...Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes
Journal of Allergy and Clinical Immunology
Nov 2012
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes
Background: Genome-wide association studies have identified associations of genetic variants at 17q21 near ORMDL3 with childhood asthma. Objectives: We sought to determine whether associations in this region are specific to particular asthma phenotypes and specific to ORMDL3. Methods: We examined associations between..Family history of Type 1 diabetes affects insulin secretion in patients with ‘Type 2’ diabetes
Diabetic Medicine
Nov 2012
Family history of Type 1 diabetes affects insulin secretion in patients with ‘Type 2’ diabetes
Aims: The aim was to evaluate the impact of family history of diabetes on the phenotype of patients diagnosed with Type 2 diabetes and the frequency of susceptibility genotypes. Methods: Patients with Type 2 diabetes with family history for both Type 1 and Type 2 diabetes (FHMIX, n = 196) or Type 2 diabetes only (FHT2,..High in vitro antimicrobial activity of β-peptoid–peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
International Journal of Antimicrobial Agents
Nov 2012
High in vitro antimicrobial activity of β-peptoid–peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis
An array of β-peptoid–peptide hybrid oligomers displaying different amino acid/peptoid compositions and chain lengths was studied with respect to antimicrobial activity against Staphylococcus epidermidis both in planktonic and biofilm cultures, comparing the effects with those of the common antibiotic vancomycin...Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
Allergy
Nov 2012
Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
Background: Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis. Methods: Human primary keratinocytes were cultured..Hypersensitivity reactions to the Sabin vaccine in children with cow's milk allergy
Clinical & Experimental Allergy
Nov 2012
Hypersensitivity reactions to the Sabin vaccine in children with cow's milk allergy
Background: The Sabin vaccine is used worldwide, and most children with food allergies receive it without incident. However, in the 2009 vaccination campaign conducted in Argentina, four children experienced immediate-type hypersensitivity reactions following vaccination. Objective: We aimed to review the medical..Improved Inflammatory Activity With Peginterferon Alfa-2b Maintenance Therapy in Non-cirrhotic Prior Nonresponders: a Randomized Study
Journal of Hepatology
Nov 2012
Improved Inflammatory Activity With Peginterferon Alfa-2b Maintenance Therapy in Non-cirrhotic Prior Nonresponders: a Randomized Study
Background and Aims: Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC3 included a prospective trial assessing long-term peginterferon alfa-2b (PEG-IFN alfa-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment...Intramuscular hemangioma of the scalene musculature masquerading as a paraganglioma: A case series
American Journal of Otolaryngology
Nov 2012
Intramuscular hemangioma of the scalene musculature masquerading as a paraganglioma: A case series
Intramuscular hemangiomas (IMHs) are uncommon benign vascular lesions, which develop in skeletal muscle. Herein, two cases of IMHs involving the cervical scalene musculature are presented. Such lesions are exceedingly rare, and can be difficult to distinguish from vagal paragangliomas based on clinical presentation,..Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
Allergy
Nov 2012
Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
Background: Chronic rhinosinusitis with nasal polyps (NP) and allergic rhinitis (AR) is characterized by local Th2 inflammation and up-regulation of IgE; however, IgE in NP is ‘polyclonal’ and allergen specific, whereas IgE in AR is ‘oligoclonal’ and allergen specific. Germinal center (GC) reactions occur in AR, while..Obesity impairs apoptotic cell clearance in asthma
Journal of Allergy and Clinical Immunology
Nov 2012
Obesity impairs apoptotic cell clearance in asthma
Background: Asthma in obese adults is typically more severe and less responsive to glucocorticoids than asthma in nonobese adults. Objective: We sought to determine whether the clearance of apoptotic inflammatory cells (efferocytosis) by airway macrophages was associated with altered inflammation and reduced..Outcomes after listing with a requirement for a prospective crossmatch in pediatric heart transplantation
Heart, Lung and Circulation
Nov 2012
Outcomes after listing with a requirement for a prospective crossmatch in pediatric heart transplantation
Background: Allosensitization is associated with inferior waitlist outcomes in pediatric heart transplant candidates, presumably because of the requirement for a negative prospective crossmatch. However, there are no reports of heart transplant candidate outcomes according to prospective crossmatch requirements...Patient-maintained propofol sedation using reaction time monitoring: a volunteer safety study
Anaesthesia
Nov 2012
Patient-maintained propofol sedation using reaction time monitoring: a volunteer safety study
Previous volunteer studies of an effect-site controlled, patient-maintained sedation system using propofol have demonstrated a risk of over-sedation. We have incorporated a reaction-time monitor into the handset of the patient-maintained sedation system to add an individualised patient-feedback mechanism. This study..Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease
Neurobiology of Aging
Nov 2012
Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease
Genome-wide association studies have identified a number of susceptibility loci in sporadic Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded the list of proposed association signals. We performed a case-control replication study in a Scandinavian population, analyzing samples from..The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia
Anaesthesia
Nov 2012
The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia
Increasing the calculated plasma concentration of propofol has been shown to increase choice reaction time and visual and auditory response times. We studied the relationship of reaction to a vibrating handset as the effect-site target-controlled propofol concentration was incrementally increased in 20 patients during..Vascular access strategy for delivering long-term antimicrobials to patients with infective endocarditis: device type, risk of infection and mortality
Journal of Hospital Infection
Nov 2012
Vascular access strategy for delivering long-term antimicrobials to patients with infective endocarditis: device type, risk of infection and mortality
Background: This paper reports the use of different vascular access devices and the incidence of intravascular catheter-related infection (CRI) in patients receiving intravenous antibiotics for infective endocarditis (IE). Aim: To examine whether rates of infection vary with type of vascular access device, and assess..Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment
Leukemia Research
Nov 2012
Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment
Peripheral T-cell lymphomas (PTCL) are a diverse group of rare non-Hodgkin lymphomas (NHL) that carry a poor prognosis and are in need of effective therapies. Alisertib (MLN8237) an investigational agent that inhibits Aurora A Ser/Thr kinase has shown activity in PTCL patients. Here we demonstrate that aurora A and B..Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences
Journal of Psychiatric Research
Nov 2012
Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences
Objective: People with schizophrenia show a high incidence of metabolic syndrome, which is associated with a high mortality from cardiovascular disease. The aetiology of the metabolic syndrome in schizophrenia is multi-factorial and may involve antipsychotic treatment, high levels of stress and unhealthy lifestyle,..Better Irrigation Delivers Better Vision: An Exploratory Study of a Novel Continuous Irrigation Sheath for a Flexible Cystoscope
Urology
Nov 2012
Better Irrigation Delivers Better Vision: An Exploratory Study of a Novel Continuous Irrigation Sheath for a Flexible Cystoscope
Objective: To evaluate the effectiveness of a novel continuous irrigation sheath (NCIS) for improving the vision of a flexible cystoscope under gross hematuria and to investigate whether this NCIS increases patient discomfort. Methods: A model was designed and a trial was conducted to quantitatively evaluate the..Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes
Leukemia Research
Nov 2012
Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes
Dendritic cells (DC) are antigen-presenting cells that play a pivotal role in coordinating functions of the immune system. Previous studies suggest that bone marrow (BM) failure in myelodysplastic syndromes (MDS) may be in part immune-mediated, and that the high propensity for relapse may reflect decreased immune..Contemporary Urethral Stricture Characteristics in the Developed World
Urology
Nov 2012
Contemporary Urethral Stricture Characteristics in the Developed World
Objective: To assess the current etiology, features, and natural history of urethral stricture disease in the developed world. Materials and Methods: We analyzed the data from 1439 male patients with urethral stricture, who had undergone surgical treatment in our referral urethral center from 2000 to 2010. The..Early Identification of Asymptomatic Subjects at Increased Risk of Heart Failure and Cardiovascular Events—Progress and Future Directions
Heart, Lung and Circulation
Nov 2012
Early Identification of Asymptomatic Subjects at Increased Risk of Heart Failure and Cardiovascular Events—Progress and Future Directions
Increasing evidence for a latent, preclinical phase of cardiac pathology prior to the development of symptomatic heart failure has fuelled interest in the potential of developing a screening program for early disease detection and intervention. Cardiac biomarkers have shown promise in identifying subjects with..Effect of Diabetes on the Ion Pumps of the Bladder
Urology
Nov 2012
Effect of Diabetes on the Ion Pumps of the Bladder
Objective: To establish whether the activities of Na+/K+-adenosine triphosphatase (ATPase) and Ca2+-ATPases ion pumps in bladder smooth muscle are altered as a consequence of diabetes and, if so, how this might contribute to bladder cystopathy. Urinary bladder dysfunction is a common occurrence in patients with..Endoscopic craniofacial resection for pediatric esthesioneuroblastoma
International Journal of Pediatric Otorhinolaryngology Extra
Nov 2012
Endoscopic craniofacial resection for pediatric esthesioneuroblastoma
Pediatric esthesioneuroblastomas are rare tumors with only about 100 reported cases. Standard surgical treatment is the open craniofacial resection. Pre-treatment imaging is critical for planning, and surgery remains the primary treatment modality followed by adjuvant therapy. We report a 12-year-old female who..Gender differences in factors influencing sexual satisfaction in Korean older adults
Archives of Gerontology and Geriatrics
Nov 2012
Gender differences in factors influencing sexual satisfaction in Korean older adults
This study investigates the sex lives of Korean older adults (i.e., those over 60 years) and attempts to identify gender-related factors influencing sexual satisfaction. It used data from the 2008 Korean National Survey on Older Adults conducted by the Ministry of Health, Welfare, and Families. Of the 15,146..Hypertension in Pediatric Patients With Renal Scarring in Association With Vesicoureteral Reflux
Urology
Nov 2012
Hypertension in Pediatric Patients With Renal Scarring in Association With Vesicoureteral Reflux
Objective: To examine the reflux nephropathy rate and severity as well as the hypertension rate in pediatric patients with vesicoureteral reflux (VUR). Methods: The study included 240 patients with VUR. Renal scarring (RS) was demonstrated by renal parenchymal examination using technetium-99m–labeled dimercaptosuccinic..Impact evaluation of a sexually transmitted disease preventive intervention among female sex workers in Hohhot, China
International Journal of Infectious Diseases
Nov 2012
Impact evaluation of a sexually transmitted disease preventive intervention among female sex workers in Hohhot, China
Objectives: The aim of this study was to evaluate the impact of HIV and sexually transmitted disease (STD) prevention interventions among female sex workers (FSWs) in the city of Hohhot in northern China. Methods: Three serial cross-sectional surveys were conducted in 2006, 2007, and 2008 among FSWs. A questionnaire..Incidence, Risk Factors, and Complications of Postoperative Delirium in Elderly Patients Undergoing Radical Cystectomy
Urology
Nov 2012
Incidence, Risk Factors, and Complications of Postoperative Delirium in Elderly Patients Undergoing Radical Cystectomy
Objective: To identify the risk factors for, and complications associated with, the development of delirium after radical cystectomy. Materials and Methods: From July 2008 to December 2009, 59 patients, aged ≥65 years and undergoing radical cystectomy, were prospectively enrolled. The baseline cognitive status was..Inducing Cell Proliferation Inhibition, Apoptosis, and Motility Reduction by Silencing Long Noncoding Ribonucleic Acid Metastasis-associated Lung Adenocarcinoma Transcript 1 in Urothelial Carcinoma of the Bladder
Urology
Nov 2012
Inducing Cell Proliferation Inhibition, Apoptosis, and Motility Reduction by Silencing Long Noncoding Ribonucleic Acid Metastasis-associated Lung Adenocarcinoma Transcript 1 in Urothelial Carcinoma of the Bladder
Objective: To study the expression patterns of long noncoding ribonucleic acid (RNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the cell proliferation inhibition, apoptosis, and motility changes induced by silencing MALAT1 in urothelial carcinoma of the bladder. Materials and Methods: The..Is hepatitis B virus transmitted via the male germ line? A seroepidemiological study in fetuses
International Journal of Infectious Diseases
Nov 2012
Is hepatitis B virus transmitted via the male germ line? A seroepidemiological study in fetuses
Objectives: To detect father-to-fetus transmission of hepatitis B virus (HBV) in utero. Methods: We conducted a study at the prenatal diagnosis center of Taizhou City. Fetuses with one or both parents carrying the hepatitis B surface antigen (HBsAg) were identified before genetic testing during the period 2008–2010...Knowledge and Attitude of European Urology Residents About Ionizing RadiationKnowledge and Attitude of European Urology Residents About Ionizing Radiation
Urology
Nov 2012
Knowledge and Attitude of European Urology Residents About Ionizing RadiationKnowledge and Attitude of European Urology Residents About Ionizing Radiation
Objective To evaluate the attitude and knowledge of urology residents concerning ionizing radiation, we undertook a survey of European urology residents. Methods The questionnaire was sent to 1184 urology residents within the database of the European Society of Residents in Urology (ESRU) by e-mail between November..Laparoendoscopic Single Site (LESS) In Vivo Suturing Using a Magnetic Anchoring and Guidance System (MAGS) Camera in a Porcine Model: Impact on Ergonomics and Workload
Urology
Nov 2012
Laparoendoscopic Single Site (LESS) In Vivo Suturing Using a Magnetic Anchoring and Guidance System (MAGS) Camera in a Porcine Model: Impact on Ergonomics and Workload
Objective: To compare the ergonomics and workload of the surgeon during single-site suturing while using the magnetic anchoring and guidance system (MAGS) camera vs a conventional laparoscope. Methods: Seven urologic surgeons were enrolled and divided into an expert group (n = 2) and a novice group (n = 5) according to..Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes
Leukemia Research
Nov 2012
Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes
We have previously demonstrated that two prognostic features of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), mutant NRAS and over-expressing BCL-2, cooperate physically and functionally in vivo. Screening of MDS patient bone marrow (BM) identified NRAS:BCL-2 co-localization in 64% cases,..Occurrence of Dysplasia and Human Papilloma Virus Typing in Penile Condylomas
Urology
Nov 2012
Occurrence of Dysplasia and Human Papilloma Virus Typing in Penile Condylomas
Objective: To determine the incidence of dysplasia as a preneoplastic change and high-risk human papilloma virus (HPV) infection in penile condylomas, which are common HPV-related lesions and considered a risk factor for penile cancer. Methods: Histologic analysis was done of 58 consecutive penile condylomas with..Probability of Downsizing Primary Tumors of Renal Cell Carcinoma by Targeted Therapies Is Related to Size at Presentation
Urology
Nov 2012
Probability of Downsizing Primary Tumors of Renal Cell Carcinoma by Targeted Therapies Is Related to Size at Presentation
Objective: To evaluate the probability of downsizing primary renal tumors by targeted therapy in correlation to size. Methods: A literature search was conducted and our own data were pooled with data of retrospective series and prospective trials in which patients were treated with tyrosine kinase inhibitors (TKIs) and..Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly
Archives of Gerontology and Geriatrics
Nov 2012
Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly
Prognostic values of N-terminal pro-brain natriuretic peptide (NT-proBNP) in myriad diseases have been studied. During the natural progression of atherosclerotic renal artery disease (ARVD) changes of NT-proBNP levels and its significance is not understood. A prospective longitudinal follow-up study was conducted among..Protective Effects of Reducing Renal Ischemia-reperfusion Injury During Renal Hilar Clamping: Use of Allopurinol as a Nephroprotective Agent
Urology
Nov 2012
Protective Effects of Reducing Renal Ischemia-reperfusion Injury During Renal Hilar Clamping: Use of Allopurinol as a Nephroprotective Agent
Objective: To investigate the relationship between renal ischemia injury and concentrations of 8-isoprostane in a rat kidney model during renal hilar clamping and their correlation with the administration of allopurinol before clamping. Materials and Methods: Reperfusion injury occurs after the reintroduction of blood..Randomised clinical trial of moxifloxacin versus ertapenem in complicated intra-abdominal infections: results of the PROMISE study
International Journal of Antimicrobial Agents
Nov 2012
Randomised clinical trial of moxifloxacin versus ertapenem in complicated intra-abdominal infections: results of the PROMISE study
Antibiotic therapy for complicated intra-abdominal infections (cIAIs) should provide broad-spectrum coverage both Gram-positive and Gram-negative microorganisms. The PROMISE study compared the clinical and bacteriological efficacy and safety of moxifloxacin versus ertapenem for the treatment of cIAIs. This randomised,..Resistance training improves cardiac output, exercise capacity and tolerance to positive airway pressure in Fontan physiology
International Journal of Cardiology
Nov 2012
Resistance training improves cardiac output, exercise capacity and tolerance to positive airway pressure in Fontan physiology
Background: Subjects with Fontan-type circulation have no sub-pulmonary ventricle and thus depend exquisitely on the respiratory bellows and peripheral muscle pump for cardiac filling. We hypothesised that resistance training to augment the peripheral muscle pump might improve cardiac filling, reduce..Risk Modelling in Quality Clinical Registries: Monitoring Lesion Treatment Failure Rate in Percutaneous Coronary Interventions
Heart, Lung and Circulation
Nov 2012
Risk Modelling in Quality Clinical Registries: Monitoring Lesion Treatment Failure Rate in Percutaneous Coronary Interventions
Aims: This paper describes the development of a risk adjustment (RA) model predictive of individual lesion treatment failure in percutaneous coronary interventions (PCI) for use in a quality monitoring and improvement program. Methods and results: Prospectively collected data for 3972 consecutive revascularisation..Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Urology
Nov 2012
Robotic Partial Nephrectomy for Solitary Kidney: A Multi-institutional Analysis
Objective: To evaluate the outcomes of robotic partial nephrectomy (RPN) for solitary kidney in a large multicenter series. Materials and Methods: Medical records of 886 consecutive patients who underwent RPN at 5 academic institutions from May 2007 to May 2012 were retrospectively analyzed. Data were prospectively..Simvastatin Suppresses Cyclophosphamide-induced Changes in Urodynamics and Bladder Inflammation
Urology
Nov 2012
Simvastatin Suppresses Cyclophosphamide-induced Changes in Urodynamics and Bladder Inflammation
Objective: To assess the ability of daily oral simvastatin administration to reduce the negative urodynamic changes associated with cyclophosphamide (CP)-induced cystitis and to prevent bladder inflammation. Patients undergoing CP chemotherapy frequently develop cystitis, leading to urinary dysfunction and hemorrhage...Standardized outpatient management of Klebsiella pneumoniae liver abscesses
International Journal of Infectious Diseases
Nov 2012
Standardized outpatient management of Klebsiella pneumoniae liver abscesses
Objectives: Community-acquired Klebsiella pneumoniae has emerged as a major cause of liver abscess in Asia. Using a standardized protocol, we conducted a prospective cohort study of all cases of K. pneumoniae liver abscess treated from 2005 to 2011 at two outpatient parenteral antimicrobial therapy (OPAT) centers in..The dietary pattern of patients with schizophrenia: A systematic review
Journal of Psychiatric Research
Nov 2012
The dietary pattern of patients with schizophrenia: A systematic review
Objective: People with schizophrenia show a high incidence of metabolic syndrome, which is associated with a high mortality from cardiovascular disease. The aetiology of the metabolic syndrome in schizophrenia is multi-factorial and may involve antipsychotic treatment, high levels of stress and unhealthy lifestyle,..The value of CMV IgG avidity and immunoblot for timing the onset of primary CMV infection in pregnancy
Journal of Clinical Virology
Nov 2012
The value of CMV IgG avidity and immunoblot for timing the onset of primary CMV infection in pregnancy
Background: Primary CMV infections in pregnancy are usually asymptomatic and only detected by serology. Estimating the onset of infection is a major diagnostic goal, since primary infections around conception and in early gestation hold a higher risk for congenital disease than those in later pregnancy. Objectives: To..β-Lactam therapeutic drug monitoring in the critically ill: optimising drug exposure in patients with fluctuating renal function and hypoalbuminaemia
International Journal of Antimicrobial Agents
Nov 2012
β-Lactam therapeutic drug monitoring in the critically ill: optimising drug exposure in patients with fluctuating renal function and hypoalbuminaemia
β-Lactams are routinely prescribed in the treatment of serious infections. Empirical dosing schedules are typically derived from studies in healthy volunteers and largely fail to consider the significant changes in antibacterial pharmacokinetics often encountered in the critically ill. These changes are primarily..A norovirus outbreak in a nursing home: Norovirus shedding time associated with age
Journal of Clinical Virology
Nov 2012
A norovirus outbreak in a nursing home: Norovirus shedding time associated with age
Background: Norovirus (NoV) GII.4 has been identified as predominant in outbreaks in the long-term health-care facilities. Objectives: NoV excretion during an outbreak of gastroenteritis affecting 19/42 residents and 12/33 employees was investigated in a Taiwan nursing home. Study design: Real-time reverse..A novel human enterovirus C (EV-C118) identified in two children hospitalised because of acute otitis media and community-acquired pneumonia in Israel
Journal of Clinical Virology
Nov 2012
A novel human enterovirus C (EV-C118) identified in two children hospitalised because of acute otitis media and community-acquired pneumonia in Israel
We report the discovery of a novel enterovirus C (EV-C118) identified in two Israeli children hospitalised for acute otitis media and community-acquired pneumonia. The highest pair-wise sequence identity scores with the EV-C109 and EV-C117 reference strains were, respectively, 63.5% and 63.6% nucleotide identity, and..Antimicrobial susceptibility and resistance mechanisms of clinical Clostridium difficile from a Chinese tertiary hospital
International Journal of Antimicrobial Agents
Nov 2012
Antimicrobial susceptibility and resistance mechanisms of clinical Clostridium difficile from a Chinese tertiary hospital
Clostridium difficile is a predominant cause of antibiotic-associated diarrhoea. It is increasingly difficult to treat C. difficile infection efficiently owing to its multidrug resistance. In the present study, 60 clinical C. difficile isolates were collected and analysed for their genotype, antimicrobial..Carbapenem-associated multidrug-resistant Acinetobacter baumannii are sensitised by aztreonam in combination with polyamines
International Journal of Antimicrobial Agents
Nov 2012
Carbapenem-associated multidrug-resistant Acinetobacter baumannii are sensitised by aztreonam in combination with polyamines
Carbapenem-associated multidrug-resistant Acinetobacter baumannii (MDR-Ab) are common among clinical isolates worldwide and are a major therapeutic challenge. Previously it was shown that exogenous polyamines (spermine and spermidine) enhanced susceptibility to β-lactams but induced resistance to polymyxins in..Efficacy and side effects of intravenous remifentanil patient-controlled analgesia used in a stepwise approach for labour: an observational study
International Journal of Obstetric Anesthesia
Nov 2012
Efficacy and side effects of intravenous remifentanil patient-controlled analgesia used in a stepwise approach for labour: an observational study
Background: Remifentanil has a suitable pharmacological profile for labour analgesia. In this prospective, observational study, intravenous patient-controlled analgesia with remifentanil, using stepwise bolus doses without background infusion, was examined during the first and second stages of labour. Outcomes were..Hemodynamic adaptation to pregnancy in women with structural heart disease
International Journal of Cardiology
Nov 2012
Hemodynamic adaptation to pregnancy in women with structural heart disease
Background: Many women with structural heart disease reach reproductive age and contemplate motherhood. Pregnancy induces and requires major hemodynamic changes. Pregnant women with structural heart disease may have a reduced cardiac reserve. There are no longitudinal data on cardiovascular adaptation throughout..Long-term outcome after extensive intestinal resection for chronic radiation enteritis
Digestive and Liver Disease
Nov 2012
Long-term outcome after extensive intestinal resection for chronic radiation enteritis
Introduction: Management of chronic radiation enteritis is often controversial, particularly due to the risk of short bowel syndrome. Methods: One hundred and seven chronic radiation enteritis patients with short bowel syndrome were studied retrospectively between 1980 and 2009. Survival and home parenteral nutrition..A case of membranous nephropathy as a manifestation of graft-versus-host disease
Kidney Research and Clinical Practice
Nov 2012
A case of membranous nephropathy as a manifestation of graft-versus-host disease
Nephrotic syndrome (NS) rarely occurs after hematopoietic stem cell transplantation (HSCT) as a late manifestation of graft-versus-host disease (GVHD). Herein, we report a case of HSCT-associated membranous nephropathy in a female patient with aplastic anemia. The patient received an allogeneic HSCT from her human..A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations
Journal of Allergy and Clinical Immunology
Nov 2012
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations
Background: IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective: We sought to identify the genetic predictors of serum total..Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis
International Journal of Antimicrobial Agents
Nov 2012
Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis
Tuberculosis (TB) is a major worldwide health problem in part due to the lack of development of new treatments and the emergence of new strains such as multidrug-resistant (MDR) and extensively drug-resistant strains that are threatening and impairing the control of this disease. In this study, the efficacy of natural..Anti-anaerobic potential of ranbezolid: insight into its mechanism of action against Bacteroides fragilis
International Journal of Antimicrobial Agents
Nov 2012
Anti-anaerobic potential of ranbezolid: insight into its mechanism of action against Bacteroides fragilis
This study reports the anti-anaerobic properties of ranbezolid, a new investigational oxazolidinone. A time–kill kinetics study against anaerobes showed that ranbezolid was superior to linezolid and killed the anaerobic pathogens at 4–8h, except forBacteroides fragilis where killing was observed at 24h. In addition,..Anti-viral triple therapy with telaprevir in haemodialysed HCV patients: Is it feasible?
Journal of Clinical Virology
Nov 2012
Anti-viral triple therapy with telaprevir in haemodialysed HCV patients: Is it feasible?
Introduction: Chronic hepatitis C virus (HCV) infection is the most common chronic liver disease in patients with end stage renal disease (ESRD) and is well known as a frequent cause of mortality and graft loss among haemodialysed and kidney transplant patients. Up to now, there are no data on antiviral efficacy and..Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors
Annals of Allergy, Asthma & Immunology
Nov 2012
Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors
Background: Atopic dermatitis (AD) is commonly associated with asthma and other atopic disorders in childhood. Objective: To evaluate the natural history of AD and its association with other allergic outcomes in a high-risk cohort through the age of 7 years. Methods: A total of 373 high-risk infants, who had undergone..Budesonide Inhalation Suspension Versus Montelukast in Children Aged 2 to 4 Years with Mild Persistent Asthma
Journal of Allergy and Clinical Immunology: In Practice
Nov 2012
Budesonide Inhalation Suspension Versus Montelukast in Children Aged 2 to 4 Years with Mild Persistent Asthma
Background: Budesonide inhalation suspension (BIS) and montelukast provide acceptable asthma control, whereas overall measures favored BIS in children aged 2 to 8 years with mild persistent asthma. Objective: We compared BIS and montelukast over a 1-year period in children aged 2 to 4 years with asthma. Methods: Data..Cannabis withdrawal in chronic cannabis users with schizophrenia
Journal of Psychiatric Research
Nov 2012
Cannabis withdrawal in chronic cannabis users with schizophrenia
Background: Chronic users of cannabis often report withdrawal symptoms after abstinence from use, but little is known about cannabis withdrawal in people with schizophrenia. Methods: Cannabis use patterns and withdrawal symptoms in adults with schizophrenia who had at least weekly cannabis use before attempting to quit..Carbapenemase-producing Enterobacteriaceae in Irish critical care units: results of a pilot prevalence survey, June 2011
Journal of Hospital Infection
Nov 2012
Carbapenemase-producing Enterobacteriaceae in Irish critical care units: results of a pilot prevalence survey, June 2011
The epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in Ireland is changing, with an increase in the number of reported cases in late 2010 and early 2011. Reported cases were predominantly linked to critical care units. In June 2011, a four-week national pilot survey took place in 40 Irish critical care..Change in sense of coherence (SOC) and symptoms of depression among old non-demented persons 12 months after hospitalization
Archives of Gerontology and Geriatrics
Nov 2012
Change in sense of coherence (SOC) and symptoms of depression among old non-demented persons 12 months after hospitalization
We studied whether SOC of older adults (≥65 years) without cognitive impairment had changed 1-year after medical hospitalization (T2) and to examine what factors were associated with the change. At baseline (T1) and (T2), the 13-item version of the SOC scale assessed coping, and the Hospital Anxiety and Depression..CMV antigenemia and quantitative viral load assessments in hematopoietic stem cell transplant recipients
Journal of Clinical Virology
Nov 2012
CMV antigenemia and quantitative viral load assessments in hematopoietic stem cell transplant recipients
Background: Sensitive and reliable diagnostic tests are essential for the prevention of cytomegalovirus (CMV) disease after hematopoietic stem cell transplantation (HSCT). pp65 antigenemia and polymerase chain reaction (PCR) assays are commonly used to monitor CMV in HSCT recipients. However, there is considerable..Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species
Xenotransplantation
Nov 2012
Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species
Background: The increasing availability of genetically engineered pigs is steadily improving the results of pig organ and cell transplantation in non-human primates (NHPs). Current techniques offer knockout of pig genes and/or knockin of human genes. Knowledge of normal values of hematologic, biochemical, coagulation,..Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness
Journal of Clinical Virology
Nov 2012
Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness
Background: Congenital cytomegalovirus (CMV) infection is the leading cause of non-genetic congenital hearing loss. The contribution of congenital CMV to prelingual deafness and the pathophysiology is largely unknown. Objective: (1) To analyze the prevalence of congenital CMV among cochlear implant (CI) recipients with..Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation
Leukemia Research
Nov 2012
Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation
Activating mutations of the c-kit gene are frequently found in CBF (core binding factor) leukemias. We evaluated the effect of tyrosine kinase inhibitor dasatinib in leukemic cell lines bearing or not c-kit mutations. Our data demonstrate that in the AML Kasumi-1 cell line, bearing the N822K c-kit mutation, dasatinib..Gender differences in the bronchoalveolar lavage cell proteome of patients with chronic obstructive pulmonary disease
Journal of Allergy and Clinical Immunology
Nov 2012
Gender differences in the bronchoalveolar lavage cell proteome of patients with chronic obstructive pulmonary disease
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and is increasing, primarily among women. Underdiagnosis is common, and because of the heterogeneous disease characteristics, molecular markers of specific disease phenotypes and more efficacious treatment..HLA-G5 in the blood of leukemia patients and healthy individuals
Leukemia Research
Nov 2012
HLA-G5 in the blood of leukemia patients and healthy individuals
In this work we focused on analysis of HLA-G5 molecules in the blood of patients with B-CLL leukemia and healthy individuals. Using sandwich ELISA, we found total soluble HLA-G, represented by sHLA-G1 and HLA-G5 in most of B-CLL patients while HLA-G5 alone was present only in few cases in both groups. These results..Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades
Journal of Allergy and Clinical Immunology
Nov 2012
Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades
Background: Human rhinoviruses (HRVs) cause common colds, and the recently discovered HRV-C is increasingly associated with lower respiratory illness among populations such as children and asthmatic patients. Objective: To determine how HRV-C is associated with respiratory illness and to evaluate changes in prevalence..Is craniosacral therapy effective for migraine? Tested with HIT-6 Questionnaire
Complementary Therapies in Clinical Practice
Nov 2012
Is craniosacral therapy effective for migraine? Tested with HIT-6 Questionnaire
Objective: To determine whether or not craniosacral therapy alleviates migraine symptoms. Methods: A cross-over experimental design was used with twenty participants, aged between 20 and 50 years, who suffered from at least two migraine attacks per month. Participants were randomly assigned to two equal-sized groups, A..Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease
Journal of Allergy and Clinical Immunology
Nov 2012
Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease
Background: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation that persists after the cessation of smoking. T cells have a major role in driving inflammation in patients with COPD and are activated by specific antigens to produce mediators, such as cytokines. The antigens that..Medical Service Encounters and Payments Associated with Topical Adjunctive Therapy Use of Timolol for Glaucoma
Clinical Drug Investigation
Nov 2012
Medical Service Encounters and Payments Associated with Topical Adjunctive Therapy Use of Timolol for Glaucoma
Background: Topical [beta]-blockers are commonly prescribed for primary open-angle glaucoma. Existing research is limited regarding respiratory or cardiovascular events that may result from using these topical [beta]-blockers. Objective: To evaluate inpatient and outpatient service encounters and payments associated..Mycobacterium fortuitum causing infection of a biventricular pacemaker/implantable cardioverter defibrillator
International Journal of Mycobacteriology
Nov 2012
Mycobacterium fortuitum causing infection of a biventricular pacemaker/implantable cardioverter defibrillator
Increased utilization of cardiovascular implantable electronic devices (CIED) has seen a corresponding rise in related infections. Non-tuberculosis mycobacteria (NTM) are rarely the cause. Treatment involves susceptibilities, antimicrobials, and device removal. This study presents a patient who underwent a..Nosocomial myiasis in a patient with diabetes
Journal of Hospital Infection
Nov 2012
Nosocomial myiasis in a patient with diabetes
This report describes a case of nosocomial myiasis caused by larvae of Sarcophaga (Bercaea) africa. The parasitosis developed in an ulcer on the heel of a patient with type 2 diabetes. The ulcer was dressed when the deposition occurred. An experiment was performed in order to demonstrate the ability of Sarcophaga..Novel DNA gyrase inhibitors: Microbiological characterisation of pyrrolamides
International Journal of Antimicrobial Agents
Nov 2012
Novel DNA gyrase inhibitors: Microbiological characterisation of pyrrolamides
Pyrrolamides are a novel class of antibacterial agents that target DNA gyrase, resulting in inhibition of DNA synthesis and bacterial cell death. In these studies, advanced compounds were shown to have potent in vitro activity against selected Gram-positive and Gram-negative pathogens, including..Parent cough-specific quality of life: Development and validation of a short form
Journal of Allergy and Clinical Immunology
Nov 2012
Parent cough-specific quality of life: Development and validation of a short form
Background: Cough is a distressing symptom and has a significant effect on many children and their families. Quality-of-life (QOL) measures provide important outcome indicators for clinicians and aid in evaluating the efficacy of interventions. Objective: The aim of this study was to develop and validate a short..Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children
Journal of Allergy and Clinical Immunology
Nov 2012
Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children
Background: We previously showed that impulse oscillometry (IOS) indices of peripheral airway function are associated with asthma control in children. However, little data exist on whether dysfunction in the peripheral airways can predict loss of asthma control. Objective: We sought to determine the utility of..Permeability factors in nephrotic syndrome and focal segmental glomerulosclerosis
Kidney Research and Clinical Practice
Nov 2012
Permeability factors in nephrotic syndrome and focal segmental glomerulosclerosis
Circulating permeability factors have been identified in the plasma of patients with focal segmental glomerulosclerosis (FSGS). Post-transplant recurrence of proteinuria, improvement of proteinuria after treatment with plasmapheresis, and induction of proteinuria in experimental animals by plasma fractions each provide..Population-based study on association between birth weight and risk of asthma: A propensity score approach
Annals of Allergy, Asthma & Immunology
Nov 2012
Population-based study on association between birth weight and risk of asthma: A propensity score approach
Background: Previous studies that assessed the role of birth weight in the risk of asthma have been limited because of selection bias and covariate imbalance. Objective: To assess the association between birth weight and risk of asthma by applying a propensity score approach. Methods: The study was designed as a..Prediction of fluid responsiveness in patients admitted to the medical intensive care unit
Journal of Critical Care
Nov 2012
Prediction of fluid responsiveness in patients admitted to the medical intensive care unit
Purpose: Accurate prediction of fluid responsiveness is of importance in the treatment of patients admitted to the intensive care unit (ICU). We investigated whether physical examination, central venous pressure (CVP), central venous oxygen saturation (ScvO2), passive leg raising (PLR) test, and transpulmonary..Severe stroke: patient profile and predictors of favourable outcome
Journal of Thrombosis and Haemostasis
Nov 2012
Severe stroke: patient profile and predictors of favourable outcome
Background: Severe stroke carries a high rate of mortality and morbidity. The aims of this study are to determine the characteristics of patients that initially presented with severe ischaemic stroke, and to identify acute and subacute predictors of favourable clinical outcome in these patients. Methodology: An..Significance of Ara h 2 in clinical reactivity and effect of cooking methods on allergenicity
Annals of Allergy, Asthma & Immunology
Nov 2012
Significance of Ara h 2 in clinical reactivity and effect of cooking methods on allergenicity
Background: The prevalence and clinical severity of peanut allergy vary between Western countries and Asia. It has been suggested that cooking methods are responsible for this discrepancy. Objectives: To evaluate the specific IgE responses to major peanut allergens in peanut allergic Korean children and to examine the..Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients
Transplant International
Nov 2012
Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients
Protocols for recipient desensitization may allow for successful kidney transplantation across major immunological barriers. Desensitized recipients, however, still face a considerable risk of antibody-mediated rejection (AMR), which underscores the need for risk stratification tools to individually tailor treatment...Testing the WHO Hand Hygiene Self-Assessment Framework for usability and reliability
Journal of Hospital Infection
Nov 2012
Testing the WHO Hand Hygiene Self-Assessment Framework for usability and reliability
Background: The World Health Organization (WHO) Hand Hygiene Self-Assessment Framework (HHSAF) was conceived as a structured self-assessment tool to provide a situation analysis of hand hygiene resources, promotion and practices within healthcare facilities. Aim: To perform usability pretesting and reliability testing..Underlying mechanisms of carbapenem resistance in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli isolates at a tertiary care centre in Lebanon: role of OXA-48 and NDM-1 carbapenemases
International Journal of Antimicrobial Agents
Nov 2012
Underlying mechanisms of carbapenem resistance in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli isolates at a tertiary care centre in Lebanon: role of OXA-48 and NDM-1 carbapenemases
A recent increase in carbapenem resistance among extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli isolates at a major tertiary care centre in Lebanon prompted the initiation of this study. Consecutive ESBL-producing isolates were tested for resistance to carbapenems, with..Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients
Journal of Diabetes and its Complications
Nov 2012
Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients
Xanthine oxidase (XOD) is a prooxidant enzyme possibly implicated in diabetic lens injury and genesis of senile cataract (SC). We evaluated the impact of diabetes on XOD activity and its relationships with lens oxidative stress markers in patients operated on for SC. Serum and lens XOD activities, lens malondialdehyde..Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase
International Journal of Antimicrobial Agents
Nov 2012
Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase
The ATP synthase of Mycobacterium tuberculosis is a validated drug target against which a diarylquinoline drug is under clinical trials. The enzyme is crucial for the viability both of actively replicating and non-replicating/dormant M. tuberculosis. Enzyme levels drop drastically as the bacilli enter dormancy and..Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms
Journal of Psychiatric Research
Nov 2012
Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms
Background: BDNF Val66Met by chronic stress interaction has been studied using childhood stress as a moderator, but has not been widely studied using chronic stress in adulthood. Methods: Two independent samples were used: Duke-CG (238 Caucasians) and MESA (5524 Caucasians, African Americans and Hispanics). Chronic..