Immunology Medical Journal Abstracts
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The combination of IKKβ inhibitor and everolimus modulates expression of IL-10 in HTLV-1-infected T cells
Immunology
Dec 2012
The combination of IKKβ inhibitor and everolimus modulates expression of IL-10 in HTLV-1-infected T cells
Adult T-cell leukemia-lymphoma (ATLL) is an aggressive malignancy of CD4+/CD25+ T lymphocytes, and characterized with severely compromised immunosystem in which the human T-cell lymphotropic virus type 1 (HTLV-1) has been recognized as the etiologic agent. This study found that an IκB kinase β (IKKβ) inhibitor..The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB/c mice
Parasite Immunology
Dec 2012
The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB/c mice
Toxoplasmosis is a world-wide zoonosis that causes significant public health and veterinary problems. The study of vaccines remains the most promising method for the future prevention and control of toxoplasmosis. Recombinant Toxoplasma gondii cyclophilin has been shown to have potent PPIase and IL-12-inducing..Dual role of IL-10 in the regulation of Respiratory Syncitial Virus (RSV)-induced lung inflammation
Clinical & Experimental Immunology
Dec 2012
Dual role of IL-10 in the regulation of Respiratory Syncitial Virus (RSV)-induced lung inflammation
RSV lower respiratory tract infections (LRTI) are among the most common diseases necessitating hospital admission in children. In addition to causing acute respiratory failure, RSV infections are associated with sequelae such as secondary bacterial infections and reactive airway disease. One characteristic host..The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation
Clinical & Experimental Immunology
Dec 2012
The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation
Recent studies indicate that chemotherapeutic agents may increase the anti-tumoral immune response. Based on the pivotal role of dendritic cells (DCs) in host tumour-specific immune responses, we investigated the effect of commonly used chemotherapeutic drugs Dexamethasone, Doxorubicin, Cisplatin and Irinotecan and..Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome
Clinical & Experimental Immunology
Dec 2012
Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome
Primary Sjögren's syndrome (pSS) is characterised by the presence of autoantibodies against the ribonucleoprotein (RNP) particles Ro/SSA and La/SS-B, and mononuclear cell infiltration of exocrine tissues, especially salivary and lachrymal glands. Low numbers of autoantigen-specific memory B cells and elevated levels of..Human Mesenchymal Stem Cells suppress donor CD4+ T cell proliferation and reduce pathology in a humanised mouse model of acute Graft versus Host Disease
Clinical & Experimental Immunology
Dec 2012
Human Mesenchymal Stem Cells suppress donor CD4+ T cell proliferation and reduce pathology in a humanised mouse model of acute Graft versus Host Disease
Acute graft versus host disease (aGvHD) is a life threatening complication following allogeneic haematopoietic stem cell transplantation (HSCT), occurring in up to 30-50% of patients who receive HLA-matched sibling transplants. Current therapies for steroid refractory aGvHD are limited, with the prognosis of patients..Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli
Clinical & Experimental Immunology
Dec 2012
Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli
Probiotics are live microorganisms, which have beneficial effects on the host when ingested in adequate amounts. Probiotic bacteria may stimulate immune effector functions in a strain specific manner. In this blind placebo-controlled trial, we investigated the effects on the immune system following daily intake of six..Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice
European Journal of Immunology
Dec 2012
Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice
We previously established an IgG Fc receptor IIB (FcγRIIB)-deficient C57BL/6 (B6)-congenic mouse strain (KO1), which spontaneously develops rheumatoid arthritis (RA), but not systemic lupus erythematosus (SLE). Here we show that when Y chromosome-linked autoimmune acceleration (Yaa) mutation was introduced in KO1..CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant natural killer T (iNKT) cells
European Journal of Immunology
Dec 2012
CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant natural killer T (iNKT) cells
Isoglobotrihexosylceramide (iGb3) has been identified as a potent CD1d-presented self-antigen for mouse iNKT cells. The role of iGb3 in humans remains unresolved, however, as there have been conflicting reports about iGb3-dependent human iNKT-cell activation, and humans lack iGb3 synthase, a key enzyme for iGb3..B-cell receptor signal strength influences terminal differentiation
European Journal of Immunology
Dec 2012
B-cell receptor signal strength influences terminal differentiation
B-cell terminal differentiation into antibody secreting plasma cells (PCs) features a transcriptional shift driven by the activation of plasma cell lineage determinants such as Blimp-1 and Xbp-1, together with the extinction of Pax5. Little is known about the signals inducing this change in transcriptional networks and..CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner
European Journal of Immunology
Dec 2012
CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner
Macrophages provide a first line of defense against bacterial infection by engulfing and killing invading bacteria, but intracellular bacteria such as Listeria monocytogenes (LM) can survive in macrophages by various mechanisms of evasion. CRIg, a C3b receptor, binds to C3b on opsonized bacteria and facilitates..Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation
European Journal of Immunology
Dec 2012
Donor Th17 cells and IL-21 may contribute to the development of chronic graft-versus-host disease after allogeneic transplantation
The roles of Th17 cells and IL-21 in the pathogenesis of chronic graft-versus-host disease (cGVHD) in patients who undergo allogeneic transplantation are still unknown. Here, we examined this question by monitoring eight patients with new-onset cGVHD for the presence of Th17 cells, Th1 cells and IL-21. Allografts from..Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome
European Journal of Immunology
Dec 2012
Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome
In a recent report we demonstrated that distinct members of the secreted aspartic protease (Sap) family of Candida albicans are able to induce secretion of proinflammatory cytokines by human monocytes, independently of their proteolytic activity and specific pH optima. In particular, Sap2 and Sap6 potently induced..Cytomegalovirus-specific T cells are detectable in early childhood and allow assignment of the infection status in children with passive maternal antibodies
European Journal of Immunology
Dec 2012
Cytomegalovirus-specific T cells are detectable in early childhood and allow assignment of the infection status in children with passive maternal antibodies
Serological identification of the cytomegalovirus (CMV) status in children <18 months of age is complicated by the variable persistence of maternal antibodies. As T cells are not passively transferred, we attempted to assess whether CMV-specific cellular immunity may be superior to determine the actual CMV-status; we..Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases
European Journal of Immunology
Dec 2012
Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases
Conditional ligands have enabled the high-throughput production of Human Leukocyte Antigen (HLA) libraries that present defined peptides. Immunomonitoring platforms typically concentrate on restriction elements associated with European ancestry, and such tools are scarce for Asian HLA variants. We report thirty novel..IL-21 synergises with IL-2 to enhance TCR-induced human T cell proliferation and counteracts IL-2/TGF-β-induced regulatory T cell development
Immunology
Dec 2012
IL-21 synergises with IL-2 to enhance TCR-induced human T cell proliferation and counteracts IL-2/TGF-β-induced regulatory T cell development
IL-2 is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T cells (Treg) development. IL-21 is a type-I cytokine acting as a potent T cell co-mitogen but less efficient than IL-2 in sustaining T cell proliferation...Dendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cells
Immunology
Dec 2012
Dendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cells
Plasmacytoid dendritic cells (pDC) in mesenteric lymph nodes (MLN) may be important regulators of both inflammatory and non-inflammatory mucosal immune responses but human studies are rare. Here we compare pDC from human MLN and peripheral blood (PB) by phenotype and function. MLN from patients with or without..Chemokine Programming Dendritic Cell Antigen Response: Part II - Programming Antigen Presentation to T Lymphocytes by Partially Maintaining Immature Dendritic Cell Phenotype
Immunology
Dec 2012
Chemokine Programming Dendritic Cell Antigen Response: Part II - Programming Antigen Presentation to T Lymphocytes by Partially Maintaining Immature Dendritic Cell Phenotype
In a companion article to this study,1 the successful programming of a JAWSII dendritic cell (DC) line's antigen uptake and processing was demonstrated based on pre-treatment of DCs with a specific “cocktail” of select chemokines. Chemokine pre-treatment modulated cytokine production before and after DC maturation (by..Chemokine Programming Dendritic Cell Antigen Response: Part I – Select Chemokine Programming of Antigen Uptake Even After Maturation
Immunology
Dec 2012
Chemokine Programming Dendritic Cell Antigen Response: Part I – Select Chemokine Programming of Antigen Uptake Even After Maturation
Here, we report on the successful of programming of dendritic cells (DCs) using selectively applied mixtures of chemokines as a novel protocol for engineering vaccine efficiency. Antigen internalization of DCs is a pivotal step in antigen uptake/presentation for bridging innate and adaptive immunity and in exogenous..Roles of repressive epigenetic machinery in lineage decision of T cells
Immunology
Dec 2012
Roles of repressive epigenetic machinery in lineage decision of T cells
DNA methylation and histone modifications are central to epigenetic gene regulation, which has been shown to play a crucial role in development. Epigenetics has often been discussed in the context of the maintenance of cell identity due to its heritable nature of gene expression status. Indeed, crucial roles of the..Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or ‘when stochasticity completes randomness’
Immunology
Dec 2012
Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or ‘when stochasticity completes randomness’
To perform their specific functional role, B and T lymphocytes, cells of the adaptive immune system of jawed vertebrates, need to express one (and, preferably, only one) form of antigen receptor, i.e., the immunoglobulin (Ig) or T cell receptor (TCR), respectively. This end goal depends initially on a series of DNA..Th17 cells contribute to anti-tumor immunity and promote the recruitment of th1 cells to the tumor
Immunology
Dec 2012
Th17 cells contribute to anti-tumor immunity and promote the recruitment of th1 cells to the tumor
T helper 17 lymphocytes (Th17) are found in high frequency in tumor-burdened animals and cancer patients. These lymphocytes, characterized by the production of IL-17 and other pro-inflammatory cytokines, have a well-defined role in the development of inflammatory and autoimmune pathologies, however their function in..Impaired macrophage phagocytosis in non-eosinophilic asthma
Clinical & Experimental Allergy
Dec 2012
Impaired macrophage phagocytosis in non-eosinophilic asthma
Background: Many patients with non-eosinophilic asthma have increased numbers of neutrophils in the airways. The explanation for this chronic inflammation remains unclear, but may result from an impaired ability of alveolar macrophages to phagocytose apoptotic cells (a process termed ‘efferocytosis’), as we have shown..Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial
Clinical & Experimental Allergy
Dec 2012
Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial
Background: Obesity and asthma are associated conditions; however, the mechanisms linking the two remain unclear. Few studies have examined the effects of weight loss on inflammation and clinical outcomes in obese–asthma. Objective: To compare the effects of weight loss achieved by dietary restriction, exercise or..Heterogeneity in the responses of human lung mast cells to stem cell factor
Clinical & Experimental Allergy
Dec 2012
Heterogeneity in the responses of human lung mast cells to stem cell factor
Background: Stem cell factor (SCF) is a growth factor that is involved in mast cell differentiation and proliferation. SCF primes human lung mast cells for enhanced responses to IgE-directed activation but is not generally recognized as a direct activator. SCF mediates its effects through c-kit. Objective: The aim of..Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study
Clinical & Experimental Allergy
Dec 2012
Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study
Background: Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age. Objective: To explore the effects of geohelminth infections and age on atopy,..Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test
Clinical & Experimental Allergy
Dec 2012
Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test
Background: Strict avoidance is the only accepted management for cow's milk (CM) allergy. CM oral immunotherapy (CM-OIT) is under investigation. Objectives: To evaluate long-term safety of CM-OIT. To identify clinical/immunological predictors of adverse events. Methods: Prospective longitudinal epidemiological..Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection
Clinical & Experimental Allergy
Dec 2012
Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection
Background: Modulation of the host immune response by helminths has been reported to be essential for parasite survival and also to benefit the host by suppressing inflammatory diseases such as allergies. We have previously shown that excretory-secretory products of Trichinella spiralis muscle larvae have..In silico prediction of Ara h 2 T cell epitopes in peanut-allergic children
Clinical & Experimental Allergy
Dec 2012
In silico prediction of Ara h 2 T cell epitopes in peanut-allergic children
Background: Despite the frequency and severity of peanut allergy, the only approved treatment is strict avoidance. Different types of immunotherapy with crude peanut extract are not universally effective and have been associated with relatively high adverse reaction rates. Objective: We sought to determine whether in..Peamaclein – A new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3
Clinical & Experimental Allergy
Dec 2012
Peamaclein – A new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3
Background: Among the peach-derived allergens which are already known, the lipid transfer protein (Pru p 3) seems to be the one to exert severe allergic reactions. Objective: To identify and characterize a new peach allergen causing a clinical picture similar to that of Pru p 3. Methods: Patients were selected on the..Specific Antibody Deficiency in Children with Recurrent Respiratory Infections: a Controlled Study with Follow-Up
Clinical & Experimental Immunology
Dec 2012
Specific Antibody Deficiency in Children with Recurrent Respiratory Infections: a Controlled Study with Follow-Up
Results: Specific antibody deficiency (SAD) to unconjugated pneumococcal vaccine (PPV) is an established primary B cell immunodeficiency. The occurrence and natural history of SAD in children is unclear. Background: We conducted an observational study to identify SAD in children with recurrent respiratory infections...Adenosine and cAMP signaling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity
Immunology
Dec 2012
Adenosine and cAMP signaling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity
Multiple endogenous mechanisms that regulate immune and inflammatory processes contribute to the maintenance of peripheral tolerance and prevent chronic inflammation in mammals. Yet pathogens and tumors are able to exploit these homeostatic pathways to foster immunosuppressive microenvironments and evade immune..CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim
Immunology
Dec 2012
CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim
Extensive studies on CD4+CD25+ regulatory T (Treg) cells suggest they are important in regulating immune responses. However, mechanisms of peripheral Treg cell homeostasis are unknown. We found that stromal cells isolated from secondary lymphoid organs such as spleen and lymph nodes could support the survival of Treg..Ragweed pollen extract intensifies LPS-induced priming of NLRP3 inflammasome in human macrophages
Immunology
Dec 2012
Ragweed pollen extract intensifies LPS-induced priming of NLRP3 inflammasome in human macrophages
Ragweed pollen extract (RWE) has been described to possess intrinsic NADPH oxidase activity that induces oxidative stress by initiating the production of intracellular reactive oxygen species (ROS). ROS are important contributors to the manifestation of the allergic inflammation, furthermore, concomitant exposure to an..Levels of prostaglandin E2 and Cysteinyl-leukotrienes in sputum supernatant of patients with asthma: The effect of smoking
Clinical & Experimental Allergy
Dec 2012
Levels of prostaglandin E2 and Cysteinyl-leukotrienes in sputum supernatant of patients with asthma: The effect of smoking
Background: Smoking is associated with worse asthma outcomes and may modify airways inflammation. Such modification may be mediated through an effect on prostaglandin E2 (PGE2) and cysteinyl leukotrienes (Cyst-LTs). Objective: We aimed to determine the levels of both PGE2 and Cyst-LTs in sputum supernatants of patients..ALOX5 Polymorphism Associates with Increased Leukotriene Production and Reduced Lung Function and Asthma Control in Children with Poorly Controlled Asthma
Clinical & Experimental Allergy
Dec 2012
ALOX5 Polymorphism Associates with Increased Leukotriene Production and Reduced Lung Function and Asthma Control in Children with Poorly Controlled Asthma
Background: Identification of risk factors for reduced asthma control could improve the understanding and treatment of asthma. A promoter polymorphism in the 5-lipoxygenase gene affects gene expression and response to asthma therapy but its impact on disease control remains unclear. Objective: We sought to determine if..Promoting Transplantation Tolerance; Adoptive Treg Cell Therapy
Clinical & Experimental Immunology
Dec 2012
Promoting Transplantation Tolerance; Adoptive Treg Cell Therapy
Transplantation is a successful treatment for end-stage organ failure. Despite improvements in short term outcome, long-term survival remains suboptimal because of the morbidity and mortality associated with long term use of immunosuppression. There is, therefore, a pressing need to devise protocols that induce..Characteristics of anaphylaxis-inducing IgG immune complexes triggering murine passive systemic anaphylaxis
Allergy
Dec 2012
Characteristics of anaphylaxis-inducing IgG immune complexes triggering murine passive systemic anaphylaxis
Background: With the broad and increasing application of therapeutic monoclonal antibodies (mAbs) in clinical settings, IgG-induced allergic reactions, including passive systemic anaphylaxis (PSA), have attracted significant attention. However, it is not clear which types of IgG mAb–antigen complexes or IgG aggregates..Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model
Allergy
Dec 2012
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model
Background: Sphingosine-1-phosphate (S1P) plays a crucial role in homeostasis of the immune system by regulating lymphocyte recirculation and inflammatory cell recruitment. The levels of S1P are tightly controlled through regulated production and controlled breakdown by sphingosine-lyase (SL). The S1P analogue FTY720..Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models
Allergy
Dec 2012
Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models
Background: Allergy is an acquired hypersensitivity reaction of the immune system mediated by cross-linking of allergen-specific IgE-bound high-affinity IgE receptors, leading to immediate mast cell degranulation. Artesunate is a semi-synthetic derivative of artemisinin, an active component of the medicinal plant..Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study
Allergy
Dec 2012
Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study
Background: Vitamin D levels are known to be associated with atopic disease development; however, existing data are controversial. The aim of this study was to investigate whether corresponding maternal and cord blood vitamin D levels are associated with atopic outcomes in early infancy. Methods: Within the LINA cohort..Mechanisms of peripheral tolerance to allergens
Allergy
Dec 2012
Mechanisms of peripheral tolerance to allergens
The immune system is regulated to protect the host from exaggerated stimulatory signals establishing a state of tolerance in healthy individuals. The disequilibrium in immune regulatory vs effector mechanisms results in allergic or autoimmune disorders in genetically predisposed subjects under certain environmental..A multicenter, randomized, controlled trial testing the effects of acupuncture on allergic rhinitis
Allergy
Dec 2012
A multicenter, randomized, controlled trial testing the effects of acupuncture on allergic rhinitis
Background: The aim of this study was to evaluate the efficacy and safety of acupuncture in the treatment for allergic rhinitis. Methods: This study was a multicenter, randomized, parallel-controlled study. Participants were randomized to either the active acupuncture, sham acupuncture, or waitlist groups. The active..Substance P antagonist improves both obesity and asthma in a mouse model
Allergy
Nov 2012
Substance P antagonist improves both obesity and asthma in a mouse model
Background: Evidence suggests a causal relationship between obesity and asthma; however, the underlying mechanisms remain unknown. Substance P (SP), involved in neurogenic inflammation by acting through its receptor NK1-R, seems to participate in obese–asthma phenotype in mice. Objectives: To evaluate the effect of a..Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA 2 LEN survey
Allergy
Nov 2012
Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA 2 LEN survey
Background: Asthma and rhinitis have been related to insomnia. The aim of this study was to further analyse the association between asthma, nasal symptoms and insomnia and to identify risk factors for sleep disturbance among patients with asthma, in a large population-based set of material. Method: In 2008, a postal..Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice
Journal of Allergy and Clinical Immunology
Nov 2012
Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice
Background: The prevalence of peanut allergies is increasing. Peanuts and many other allergen sources contain significant amounts of triglycerides, which affect absorption of antigens but have unknown effects on sensitization and anaphylaxis. We recently reported that dietary medium-chain triglycerides (MCTs), which..DJ-1 regulates mast cell activation and IgE-mediated allergic responses
Journal of Allergy and Clinical Immunology
Nov 2012
DJ-1 regulates mast cell activation and IgE-mediated allergic responses
Background: DJ-1 is an antioxidant protein known to reduce levels of reactive oxygen species (ROS), but its presence or function in mast cells and allergic diseases is unknown. Objectives: We sought to determine the role and mechanism of DJ-1 in allergic responses in vitro and in vivo. Methods: ROS and DJ-1 levels in..Timing of infant feeding in relation to childhood asthma and allergic diseases
Journal of Allergy and Clinical Immunology
Nov 2012
Timing of infant feeding in relation to childhood asthma and allergic diseases
Background: Emerging evidence questions current recommendations on the timing of infant feeding for the prevention of childhood allergies. The evidence for asthma is inconclusive. Objective: We sought to investigate the associations between the duration of breast-feeding and timing of introduction of complementary..Primary Prevention of Allergic Disease Through Nutritional Interventions
Journal of Allergy and Clinical Immunology
Nov 2012
Primary Prevention of Allergic Disease Through Nutritional Interventions
With the rising prevalence of atopic disease, primary prevention may play a role in reducing its burden, especially in high-risk infants. With this in mind, the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology was charged with the task of developing recommendations for..Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment
Clinical & Experimental Allergy
Nov 2012
Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment
Background: Plasmacytoid dendritic cells (pDCs) infiltrate sites of acute Th2-dominant inflammation but their role in allergic asthma remains unclear. Objective: To characterise circulating pDCs from patients with allergic asthma outside their respective allergen season. Methods: Adhesion molecules, co-stimulatory..Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants
Clinical & Experimental Allergy
Nov 2012
Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants
Background: Culture-dependent methods have shown that meconium, the newborn's first intestinal discharge, is not sterile, but the diversity of bacteria present in this material needs to be further characterized by means of more sensitive molecular techniques. Objective: Our aims were to characterize molecularly the..Identifying infants at high risk of peanut allergy: The Learning Early About Peanut Allergy (LEAP) screening study
Journal of Allergy and Clinical Immunology
Nov 2012
Identifying infants at high risk of peanut allergy: The Learning Early About Peanut Allergy (LEAP) screening study
Background: Peanut allergy (PA) is rare in countries in which peanuts are introduced early into infants’ diets. Learning Early About Peanut Allergy (LEAP) is an interventional study aiming to assess whether PA can be prevented by oral tolerance induction. Objective: We sought to characterize a population screened for..Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity
Journal of Allergy and Clinical Immunology
Nov 2012
Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity
Background: Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying physiologic and immunologic processes are not fully understood. Objective: The aim of this study was to determine whether TH9 cells develop in vivo in a model of chronic airway hyperreactivity (AHR) and what factors..IL-22 suppresses IFN-γ–mediated lung inflammation in asthmatic patients
Journal of Allergy and Clinical Immunology
Nov 2012
IL-22 suppresses IFN-γ–mediated lung inflammation in asthmatic patients
Background: IL-22 controls tissue homeostasis by both proinflammatory and anti-inflammatory effects. However, the anti-inflammatory mechanisms of IL-22 remain poorly investigated. Objective: We sought to investigate the anti-inflammatory role for IL-22 in human asthma. Methods: T-cell lines derived from lung biopsy..Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
Journal of Allergy and Clinical Immunology
Nov 2012
Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients
Background: The D-prostanoid receptor and the chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) are implicated in asthma pathogenesis. AMG 853 is a potent, selective, orally bioavailable, small-molecule dual antagonist of human D-prostanoid and CRTH2. Objective: We sought to determine the..The identification of potentially pathogenic and therapeutic epitopes from common human allergens
Annals of Allergy, Asthma & Immunology
Nov 2012
The identification of potentially pathogenic and therapeutic epitopes from common human allergens
Objectives: To outline the processes involved in large-scale T-cell epitope identification from common allergens and illustrate their relevance to development of allergy specific immunotherapy. Data Sources: A set of studies recently published by our laboratory illustrating high-throughput identification of allergen..Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium
Annals of Allergy, Asthma & Immunology
Nov 2012
Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium
Background: Air pollution from road traffic is a serious public health problem. Epidemiologic studies have demonstrated adverse health effects associated with environmental pollution. Diesel exhaust is a major contributor to ambient particulate matter air pollution. We studied the effects of exposure to diesel exhaust..Asthma severity in childhood and metabolomic profiling of breath condensate
Allergy
Nov 2012
Asthma severity in childhood and metabolomic profiling of breath condensate
Background: Asthma is a heterogeneous disease and its different phenotypes need to be better characterized from a biochemical-inflammatory standpoint. This study aimed to apply the metabolomic approach to exhaled breath condensate (breathomics) to discriminate different asthma phenotypes, with a particular focus on..Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns
Allergy
Nov 2012
Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns
Background: The remodeling patterns in different types of chronic rhinosinusitis (CRS) have rarely been compared, particularly the difference between eosinophilic and noneosinophilic CRS with nasal polyps (CRSwNP). Moreover, whether there is a link between remodeling and inflammation remains controversial. Objective:..Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Journal of Allergy and Clinical Immunology
Nov 2012
Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Background: Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis. Objectives: We sought to gather clinical data of IL-10/IL-10R–deficient patients and devise guidelines for diagnosis and management, including hematopoietic stem cell..Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Journal of Allergy and Clinical Immunology
Nov 2012
Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Background: Inherited deficiencies of IL-10 or IL-10 receptor (IL-10R) lead to immune dysregulation with life-threatening early-onset enterocolitis. Objectives: We sought to gather clinical data of IL-10/IL-10R–deficient patients and devise guidelines for diagnosis and management, including hematopoietic stem cell..EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria
Allergy
Nov 2012
EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria
An autoimmune subset of chronic spontaneous urticaria is increasingly being recognized internationally, based on laboratory and clinical evidence that has accrued over the last 20 years. This evidence has been reviewed by a taskforce of the Dermatology section of the European Academy of Allergy and Clinical Immunology...Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
Allergy
Nov 2012
Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
Background: Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis. Methods: Human primary keratinocytes were cultured..Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
Allergy
Nov 2012
Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps
Background: Chronic rhinosinusitis with nasal polyps (NP) and allergic rhinitis (AR) is characterized by local Th2 inflammation and up-regulation of IgE; however, IgE in NP is ‘polyclonal’ and allergen specific, whereas IgE in AR is ‘oligoclonal’ and allergen specific. Germinal center (GC) reactions occur in AR, while..Hypersensitivity reactions to the Sabin vaccine in children with cow's milk allergy
Clinical & Experimental Allergy
Nov 2012
Hypersensitivity reactions to the Sabin vaccine in children with cow's milk allergy
Background: The Sabin vaccine is used worldwide, and most children with food allergies receive it without incident. However, in the 2009 vaccination campaign conducted in Argentina, four children experienced immediate-type hypersensitivity reactions following vaccination. Objective: We aimed to review the medical..Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility
Clinical & Experimental Allergy
Nov 2012
Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility
Background: Genetic studies have identified numerous genes reproducibly associated with asthma, yet these studies have focused almost entirely on single nucleotide polymorphisms (SNPs), and virtually ignored another highly prevalent form of genetic variation: Copy Number Variants (CNVs). Objective: To survey the..Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes
Journal of Allergy and Clinical Immunology
Nov 2012
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes
Background: Genome-wide association studies have identified associations of genetic variants at 17q21 near ORMDL3 with childhood asthma. Objectives: We sought to determine whether associations in this region are specific to particular asthma phenotypes and specific to ORMDL3. Methods: We examined associations between..Anaphylaxis from ingestion of mites: Pancake anaphylaxis
Journal of Allergy and Clinical Immunology
Nov 2012
Anaphylaxis from ingestion of mites: Pancake anaphylaxis
Oral mite anaphylaxis is a new syndrome characterized by severe allergic symptoms occurring immediately after eating foods made with mite-contaminated wheat flour. This syndrome, which is more prevalent in tropical environments, is triggered more often by pancakes, and for that reason, it has been designated “the..Obesity impairs apoptotic cell clearance in asthma
Journal of Allergy and Clinical Immunology
Nov 2012
Obesity impairs apoptotic cell clearance in asthma
Background: Asthma in obese adults is typically more severe and less responsive to glucocorticoids than asthma in nonobese adults. Objective: We sought to determine whether the clearance of apoptotic inflammatory cells (efferocytosis) by airway macrophages was associated with altered inflammation and reduced..Examination of the relationship between variation at 17q21 and childhood wheeze phenotypestionship between variation at 17q21 and childhood wheeze phenotypes
Journal of Allergy and Clinical Immunology
Nov 2012
Examination of the relationship between variation at 17q21 and childhood wheeze phenotypestionship between variation at 17q21 and childhood wheeze phenotypes
Background: Genome-wide association studies have identified associations of genetic variants at 17q21 near ORMDL3 with childhood asthma. Objectives: We sought to determine whether associations in this region are specific to particular asthma phenotypes and specific to ORMDL3. Methods: We examined associations between..Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children
Journal of Allergy and Clinical Immunology
Nov 2012
Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children
Background: We previously showed that impulse oscillometry (IOS) indices of peripheral airway function are associated with asthma control in children. However, little data exist on whether dysfunction in the peripheral airways can predict loss of asthma control. Objective: We sought to determine the utility of..Gender differences in the bronchoalveolar lavage cell proteome of patients with chronic obstructive pulmonary disease
Journal of Allergy and Clinical Immunology
Nov 2012
Gender differences in the bronchoalveolar lavage cell proteome of patients with chronic obstructive pulmonary disease
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and is increasing, primarily among women. Underdiagnosis is common, and because of the heterogeneous disease characteristics, molecular markers of specific disease phenotypes and more efficacious treatment..Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease
Journal of Allergy and Clinical Immunology
Nov 2012
Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease
Background: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation that persists after the cessation of smoking. T cells have a major role in driving inflammation in patients with COPD and are activated by specific antigens to produce mediators, such as cytokines. The antigens that..A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations
Journal of Allergy and Clinical Immunology
Nov 2012
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations
Background: IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. Objective: We sought to identify the genetic predictors of serum total..Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades
Journal of Allergy and Clinical Immunology
Nov 2012
Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades
Background: Human rhinoviruses (HRVs) cause common colds, and the recently discovered HRV-C is increasingly associated with lower respiratory illness among populations such as children and asthmatic patients. Objective: To determine how HRV-C is associated with respiratory illness and to evaluate changes in prevalence..Parent cough-specific quality of life: Development and validation of a short form
Journal of Allergy and Clinical Immunology
Nov 2012
Parent cough-specific quality of life: Development and validation of a short form
Background: Cough is a distressing symptom and has a significant effect on many children and their families. Quality-of-life (QOL) measures provide important outcome indicators for clinicians and aid in evaluating the efficacy of interventions. Objective: The aim of this study was to develop and validate a short..Budesonide Inhalation Suspension Versus Montelukast in Children Aged 2 to 4 Years with Mild Persistent Asthma
Journal of Allergy and Clinical Immunology: In Practice
Nov 2012
Budesonide Inhalation Suspension Versus Montelukast in Children Aged 2 to 4 Years with Mild Persistent Asthma
Background: Budesonide inhalation suspension (BIS) and montelukast provide acceptable asthma control, whereas overall measures favored BIS in children aged 2 to 8 years with mild persistent asthma. Objective: We compared BIS and montelukast over a 1-year period in children aged 2 to 4 years with asthma. Methods: Data..Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors
Annals of Allergy, Asthma & Immunology
Nov 2012
Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors
Background: Atopic dermatitis (AD) is commonly associated with asthma and other atopic disorders in childhood. Objective: To evaluate the natural history of AD and its association with other allergic outcomes in a high-risk cohort through the age of 7 years. Methods: A total of 373 high-risk infants, who had undergone..Population-based study on association between birth weight and risk of asthma: A propensity score approach
Annals of Allergy, Asthma & Immunology
Nov 2012
Population-based study on association between birth weight and risk of asthma: A propensity score approach
Background: Previous studies that assessed the role of birth weight in the risk of asthma have been limited because of selection bias and covariate imbalance. Objective: To assess the association between birth weight and risk of asthma by applying a propensity score approach. Methods: The study was designed as a..Significance of Ara h 2 in clinical reactivity and effect of cooking methods on allergenicity
Annals of Allergy, Asthma & Immunology
Nov 2012
Significance of Ara h 2 in clinical reactivity and effect of cooking methods on allergenicity
Background: The prevalence and clinical severity of peanut allergy vary between Western countries and Asia. It has been suggested that cooking methods are responsible for this discrepancy. Objectives: To evaluate the specific IgE responses to major peanut allergens in peanut allergic Korean children and to examine the..Budesonide Inhalation Suspension Versus Montelukast in Children Aged 2 to 4 Years with Mild Persistent Asthma
Journal of Allergy and Clinical Immunology: In Practice
Nov 2012
Budesonide Inhalation Suspension Versus Montelukast in Children Aged 2 to 4 Years with Mild Persistent Asthma
Background: Budesonide inhalation suspension (BIS) and montelukast provide acceptable asthma control, whereas overall measures favored BIS in children aged 2 to 8 years with mild persistent asthma. Objective: We compared BIS and montelukast over a 1-year period in children aged 2 to 4 years with asthma. Methods: Data..Functional variants in the thromboxane A2 receptor gene are associated with lung function in childhood-onset asthma
Clinical & Experimental Allergy
Nov 2012
Functional variants in the thromboxane A2 receptor gene are associated with lung function in childhood-onset asthma
Background: The thromboxane A2 receptor (TBXA2R) gene is associated with asthma, but no functional genetic variations are known to associate with the disease or its related phenotypes. Objective: To investigate the association of TBXA2R polymorphisms with asthma susceptibility and related phenotypes and to identify..Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens
Journal of Allergy and Clinical Immunology
Nov 2012
Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens
Background: Kiwifruit is a common cause of food allergy. Symptoms range from mild to anaphylactic reactions. Objective: We sought to elucidate geographic differences across Europe regarding clinical patterns and sensitization to kiwifruit allergens. Factors associated with the severity of kiwifruit allergy were..Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency
Journal of Allergy and Clinical Immunology
Nov 2012
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency
Background: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP) expression, resulting in defective function of many immune cell lineages and susceptibility to severe bacterial, viral, and fungal infections. Despite a significant..Component resolved diagnosis of wasp (yellow jacket) venom allergy
Clinical & Experimental Allergy
Nov 2012
Component resolved diagnosis of wasp (yellow jacket) venom allergy
Background: Wasp venom allergy is a potentially life-threatening condition with serious consequences of diagnostic error. Objective: To assess whether component resolved diagnosis, using non-glycosylated recombinant allergen components from yellow jacket can add to the diagnosis of wasp venom allergy. Methods: In total..Tropomyosin from tilapia (Oreochromis mossambicus) as an allergen
Clinical & Experimental Allergy
Nov 2012
Tropomyosin from tilapia (Oreochromis mossambicus) as an allergen
Background: Tilapia is among the most common fresh water fish species raised by fish farms and can cause allergic reactions upon ingestion. Objective: Investigate important allergens in Tilapia (Oreochromis mossambicus). Methods: Allergens were detected using immunoblotting. An important allergen was purified to..Benefits of progestin contraception in non-allergic angioedema
Clinical & Experimental Allergy
Nov 2012
Benefits of progestin contraception in non-allergic angioedema
Background: Hereditary angioedema attacks can be induced or worsened by oral contraceptive containing estrogens. Objectives: The purpose of this study was to assess the impact of progestin contraceptives on angioedema attacks. Methods: We conducted a French retrospective, multicenter study of progestin contraception in..Genome-wide association study of body mass index in 23,000 individuals with and without asthma
Clinical & Experimental Allergy
Nov 2012
Genome-wide association study of body mass index in 23,000 individuals with and without asthma
Background: Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co-morbidity between these conditions. Objective: To identify genetic variants that are..Leukotriene Receptor Antagonists in Allergic Eye Disease: A Systematic Review and Meta-analysis
Journal of Allergy and Clinical Immunology: In Practice
Nov 2012
Leukotriene Receptor Antagonists in Allergic Eye Disease: A Systematic Review and Meta-analysis
Background: Allergic eye diseases are common and cause significant morbidity. Leukotrienes are implicated in the pathogenesis of seasonal and perennial allergic conjunctivitis (AC), commonly seen in conjunction with allergic rhinitis, and in vernal keratoconjunctivitis and atopic keratoconjunctivitis. Objectives: To..Use of Metered-Dose Inhaler Electronic Monitoring in a Real-World Asthma Randomized Controlled Trial Published
Journal of Allergy and Clinical Immunology: In Practice
Nov 2012
Use of Metered-Dose Inhaler Electronic Monitoring in a Real-World Asthma Randomized Controlled Trial Published
Background: Electronic monitoring of inhaled asthma medications is one method to measure medication adherence and patterns of use. Information on the performance of monitors in a randomized controlled trial allows researchers and clinicians to understand their utility and limitations. The Smartinhaler Tracker is an..Association Between Consistent Omalizumab Treatment and Asthma Control
Journal of Allergy and Clinical Immunology: In Practice
Nov 2012
Association Between Consistent Omalizumab Treatment and Asthma Control
Background: Omalizumab is indicated for patients with moderate-to-severe allergic asthma with inadequately controlled symptoms. Objective: We evaluated the association between consistent omalizumab treatment and asthma control. Methods: Health insurance claims from the MarketScan database (2002Q1-2011Q2) were analyzed...Non-Allergic, Mastocytosis Associated Rhinitis
Clinical & Experimental Allergy
Nov 2012
Non-Allergic, Mastocytosis Associated Rhinitis
Background: Systemic mastocytosis (SM) is a clonal proliferative disorder of mast cells (MC) that causes pathological accumulation of mast cells in various tissues, which results in clinical symptoms (e.g. diarrhoea, urticaria) due to MC mediator release. Previous studies have shown that up to fifty percent of rhinitis..Phosphodiesterase-4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress
Allergy
Nov 2012
Phosphodiesterase-4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress
Background: Several clinical studies have shown that smoking in asthmatics and chronic obstructive pulmonary disease patients is closely associated with corticosteroid refractoriness. In this work, we have analyzed glucocorticoid insensitivity in human pulmonary artery endothelial cells (HPAECs) under cigarette smoke..Recombinant human C1 inhibitor for the prophylaxis of hereditary angioedema attacks: a pilot study
Allergy
Nov 2012
Recombinant human C1 inhibitor for the prophylaxis of hereditary angioedema attacks: a pilot study
Background: Hereditary angioedema (HAE) is a disease characterized by recurrent tissue swelling affecting various body locations. Recent literature shows that patients with frequent attacks may benefit from long-term prophylaxis. This study evaluated the safety and prophylactic effect of weekly administrations of..Specific Patterns of Allergic Sensitization in Early Childhood and Asthma & Rhinitis Risk
Clinical & Experimental Allergy
Nov 2012
Specific Patterns of Allergic Sensitization in Early Childhood and Asthma & Rhinitis Risk
Background: Specific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk. Objective: To define relationships among established sensitization to particular aeroallergens, quantitative analyses..Clinical efficacy of 300IR 5-grass pollen sublingual tablet in a US study: The importance of allergen-specific serum IgE
Journal of Allergy and Clinical Immunology
Nov 2012
Clinical efficacy of 300IR 5-grass pollen sublingual tablet in a US study: The importance of allergen-specific serum IgE
Background: Previous trials have demonstrated the efficacy, safety, and optimal dosage of the 5-grass pollen sublingual tablet for adults and children with grass pollen–induced allergic rhinoconjunctivitis. Objectives: We sought to evaluate the efficacy and safety of 300 index of reactivity (IR) 5-grass pollen..Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine
Allergy
Oct 2012
Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine
Atopic dermatitis (AD) is a paradigmatic inflammatory chronic skin disease. As for other chronic skin diseases, (i) the spectrum of the clinical phenotype and severity as well as (ii) the genetic background and (iii) the underlying mechanisms strongly suggest a high degree of pathophysiological heterogeneity yet..Novel insights into mechanisms of food allergy and allergic airway inflammation using experimental mouse models
Allergy
Oct 2012
Novel insights into mechanisms of food allergy and allergic airway inflammation using experimental mouse models
Over the last decades, considerable efforts have been undertaken in the development of animal models mimicking the pathogenesis of allergic diseases occurring in humans. The mouse has rapidly emerged as the animal model of choice, due to considerations of handling and costs and, importantly, due to the availability of..Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients
Journal of Allergy and Clinical Immunology
Oct 2012
Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening cutaneous reactions caused by drugs or infections and exhibiting widespread epidermal necrosis. Currently, there is no animal model that reproduces SJS/TEN symptoms. Objective: We sought to develop a novel mouse model..Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity
Journal of Allergy and Clinical Immunology
Oct 2012
Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity
Background: IL-10–treated dendritic cells (DCs) have been shown to inhibit T-cell responses through induction of anergy and regulatory T cells in various model systems, including allergic inflammation, but the factors being involved in this inhibition are still unclear. Objective: This study set out to analyze such..Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease
Journal of Allergy and Clinical Immunology
Oct 2012
Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease
Background: Allergic asthma is a TH2-promoted hyperreactivity with an immediate, IgE, and mast cell–dependent response followed by eosinophil-dominated inflammation and airway obstruction. Objective: Because costimulation by CD28 is essential for TH2 but not TH1 responses, we investigated the effect of selective..Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life
Clinical & Experimental Allergy
Oct 2012
Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life
Background: Oral supplementation with probiotic bacteria can protect against the development of allergic and inflammatory diseases. Objective: The aim of this study was to investigate potential immunomodulatory and allergy protective effects of processed Lactobacillus rhamnosus GG (LGG)-derived supernatants early in..Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood
Clinical & Experimental Allergy
Oct 2012
Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood
Background: Epigenetic modifications may have a role in asthma susceptibility. Objective: To investigate whether epigenetic modification at birth of a CpG site necessary for regulation of IL-2 transcription (IL-2 Site1) is associated with the development of asthma during childhood. Methods: Methylation of IL-2 Site1..IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization
Allergy
Oct 2012
IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization
Background: There are no available clinical tests that can accurately predict peanut allergy (PA) and/or anaphylaxis. This study is aimed at evaluating whether the component-resolved diagnostic (CRD) IgE and IgG4 tests can (i) distinguish PA from asymptomatic peanut sensitization (PS) and (ii) differentiate..Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy
Annals of Allergy, Asthma & Immunology
Oct 2012
Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy
Background: Anaphylaxis to egg or severe egg allergy has been considered a contraindication to receiving trivalent seasonal influenza vaccine (TIV). Objective: To evaluate the safety of TIV among severely egg allergic children. Methods: A 2-phase, multicenter study at 7 sites was conducted between October 2010 and..Sensitivity of impulse oscillometry and spirometry in beta-blocker induced bronchoconstriction and beta-agonist bronchodilatation in asthma
Annals of Allergy, Asthma & Immunology
Oct 2012
Sensitivity of impulse oscillometry and spirometry in beta-blocker induced bronchoconstriction and beta-agonist bronchodilatation in asthma
Background: Impulse oscillometry (IOS) provides an alternative method of assessing pulmonary function to conventional spirometry. Objective: To compare the sensitivities of IOS and spirometry in assessing bronchoconstriction to propranolol and bronchodilation with salbutamol. Methods: A post-hoc analysis of a..Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant
Journal of Allergy and Clinical Immunology
Oct 2012
Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant
Background: Probiotics have shown promising potential in reducing the risk of eczema in infants. Optimal probiotic intervention regimen remains to be determined. Objective: We investigated whether maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of developing eczema in high-risk..The prevalence and characteristics of food allergy in urban minority children
Annals of Allergy, Asthma & Immunology
Oct 2012
The prevalence and characteristics of food allergy in urban minority children
Background: Urban minority children are known to have high rates of asthma and allergic rhinitis, but little is known about food allergy in this population. Objective: To examine the prevalence and characteristics of food allergy in an urban pediatric population. Methods: A retrospective review of electronic medical..An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE
Allergy
Oct 2012
An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE
Background: Analyses of the molecular basis underlying allergenicity and allergen cross-reactivity, as well as improvement of allergy diagnostics and therapeutics, are hampered by the lack of human monoclonal IgE antibodies and knowledge about their epitopes. Here, we addressed the consecutive generation and epitope..Short-term venom immunotherapy induces desensitization of FcεRI-mediated basophil response
Allergy
Oct 2012
Short-term venom immunotherapy induces desensitization of FcεRI-mediated basophil response
Background: The precise immunological mechanisms for the early clinical protection of venom immunotherapy (VIT) have not yet been explained. Our aim was to evaluate whether high-affinity IgE receptor (FcεRI) and the related basophil function have a role in the induction of short-term VIT protection. Methods: We..Do mast cells link obesity and asthma?
Allergy
Oct 2012
Do mast cells link obesity and asthma?
Asthma is a chronic inflammatory disease of the lungs. Both the number of cases and severity of asthma have been increasing without a clear explanation. Recent evidence suggests that obesity, which has also been increasing alarmingly, may worsen or precipitate asthma, but there is little evidence of how obesity may..Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes
Journal of Allergy and Clinical Immunology
Oct 2012
Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes
Background: Control of HIV is suggested to depend on potent effector functions of the virus-specific CD8+ T-cell response. Antigen opsonization can modulate the capture of antigen, its presentation, and the priming of specific CD8+ T-cell responses. Objective: We have previously shown that opsonization of retroviruses..A population analysis of prescriptions for asthma medications during pregnancy
Journal of Allergy and Clinical Immunology
Oct 2012
A population analysis of prescriptions for asthma medications during pregnancy
Background: It is important to control asthma during pregnancy. However, some studies indicate that women stop or change their asthma medications when they become pregnant. Objective: We used a population database to analyze changes in prescriptions for asthma medications to patients before, during, and after..The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts
Journal of Allergy and Clinical Immunology
Oct 2012
The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts
Background: IL-13 is key mediator of allergic inflammation in asthmatic patients. We have previously shown that the decoy receptor IL-13 receptor (IL-13R) α2 attenuates responses of fibroblasts to IL-13. Because the expression of IL-13Rα2 can be regulated by IFN-γ, a type II interferon, we hypothesized that innate..Can a school-based hand hygiene program reduce asthma exacerbations among elementary school children?
Journal of Allergy and Clinical Immunology
Oct 2012
Can a school-based hand hygiene program reduce asthma exacerbations among elementary school children?
Background: Viral upper respiratory tract infections have been implicated as a major cause of asthma exacerbations among school-aged children. Regular hand washing is the most effective method to prevent the spread of viral respiratory tract infections, but effective hand-washing practices are difficult to establish in..Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma
Journal of Allergy and Clinical Immunology
Oct 2012
Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma
Background: There are large and persisting disparities in severe asthma exacerbations by race-ethnicity, and African American subjects are among those at greatest risk. It is unclear whether this increased risk solely represents differences in environmental exposures and health care or whether there is a predisposing..Increased airway smooth muscle in preschool wheezers who have asthma at school age
Journal of Allergy and Clinical Immunology
Oct 2012
Increased airway smooth muscle in preschool wheezers who have asthma at school age
Background: Increased airway smooth muscle (ASM) is a feature of established asthma in schoolchildren, but nothing is known about ASM in preschool wheezers. Objective: We sought to determine endobronchial biopsy specimen ASM area fraction in preschool wheezers and its association with asthma at school age. Methods: ASM..Inappropriate home albuterol use during an acute asthma exacerbation
Annals of Allergy, Asthma & Immunology
Oct 2012
Inappropriate home albuterol use during an acute asthma exacerbation
Background: Increased asthma morbidity and mortality is associated with inappropriate home self-management skills. Objectives: To examine the proportion of children presenting to the emergency department (ED) with an acute asthma exacerbation with incorrect home use of their albuterol inhaler and to identify factors..Efficacy of venom immunotherapy given every 3 or 4 months: a prospective comparison with the conventional regimen
Annals of Allergy, Asthma & Immunology
Oct 2012
Efficacy of venom immunotherapy given every 3 or 4 months: a prospective comparison with the conventional regimen
Background: Standard venom immunotherapy involves the administration of the maintenance dose every 4 to 6 weeks. This regimen may have adherence problems, especially in the long term; thus, extended intervals have been proposed. Objective: We prospectively compared the efficacy of 3- or 4-month extended maintenance..Clarifying the transmission route of Staphylococcus aureus colonizing the skin in early childhood atopic dermatitis
Annals of Allergy, Asthma & Immunology
Oct 2012
Clarifying the transmission route of Staphylococcus aureus colonizing the skin in early childhood atopic dermatitis
Background: We previously found that skin-colonizing Staphylococcus aureus in early childhood atopic dermatitis (AD) originates predominantly from the patient's nose, whereas maternal transmission did not contribute substantially to colonization. Objective: To investigate the transmission route and definitive source of..Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice
Allergy
Oct 2012
Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice
Background: Transforming growth factor (TGF)-β1 produced in airway epithelia has been suggested as a contributor to the airway remodeling observed in asthma patients. The protein tyrosine phosphatase SHP2 is a demonstrable modulator of TGF-β1 production and thus a potential regulator of airway remodeling. Objectives:..Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes
Journal of Allergy and Clinical Immunology
Oct 2012
Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes
Background: The innate immune system is essential for host survival because of its ability to recognize invading pathogens and mount defensive responses. Objectives: We sought to identify genetic associations of innate immunity genes with atopy and asthma and interactions with early viral infections (first 12 months of..Evaluation and validation of a bee venom sting challenge performed by a micro-syringe
Annals of Allergy, Asthma & Immunology
Oct 2012
Evaluation and validation of a bee venom sting challenge performed by a micro-syringe
Background: The honeybee sting challenge is considered a reliable procedure to evaluate the efficacy of specific immunotherapy, but it is difficult and unpractical to perform in clinical practice, because live insects are required. Objective: To assess the feasibility and reliability of a challenge test using a..The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis
Journal of Allergy and Clinical Immunology
Oct 2012
The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis
Background: Currently, the cornerstone of asthma management is the achievement and maintenance of optimal asthma control, but the diagnostic performances of the Asthma Control Test (ACT) and Asthma Control Questionnaire (ACQ) have not been evaluated systematically. Objective: We explored the diagnostic performances of..Work-exacerbated asthma and occupational asthma: Do they really differ?
Journal of Allergy and Clinical Immunology
Oct 2012
Work-exacerbated asthma and occupational asthma: Do they really differ?
Background: Although work-exacerbated asthma (WEA) is a prevalent condition likely to have an important societal burden, there are limited data on this condition. Objectives: The aims of this study were (1) to compare the clinical, functional, and inflammatory characteristics of workers with WEA and occupational asthma..Prevalence and abundance of Staphylococcus aureus in the middle meatus of patients with chronic rhinosinusitis, nasal polyps, and asthma
International Forum of Allergy & Rhinology
Oct 2012
Prevalence and abundance of Staphylococcus aureus in the middle meatus of patients with chronic rhinosinusitis, nasal polyps, and asthma
Background: Chronic rhinosinusitis (CRS) is an idiosyncratic and multifactorial disease process. Bacteria play a role in some patients, by infection or stimulation of inflammation. Staphylococcus aureus (SA) appears to be implicated in a number of infectious and inflammatory mechanisms, and may be particularly relevant..Safety of intradermal skin tests for inhalants and foods: a prospective study
International Forum of Allergy & Rhinology
Oct 2012
Safety of intradermal skin tests for inhalants and foods: a prospective study
Background: Intradermal skin testing is a useful allergy diagnostic tool. Although considered safe when properly performed, systemic reactions have been reported. This is the first large, prospective study to record and evaluate all systemic reactions from intradermal skin testing (IDT) to inhalant or food antigens...Efficacy and safety of a once-daily sublingual immunotherapy without escalation regimen in house dust mite–induced allergic rhinitis
International Forum of Allergy & Rhinology
Oct 2012
Efficacy and safety of a once-daily sublingual immunotherapy without escalation regimen in house dust mite–induced allergic rhinitis
Background: The conventional escalation regimen for sublingual immunotherapy (SLIT) in patients with allergic rhinitis has been proven to be safe and successful in reducing allergic symptoms. However, few studies compared the efficacy and safety between a conventional escalation regimen for SLIT and once-daily SLIT...Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs
Journal of Allergy and Clinical Immunology
Oct 2012
Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs
Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified AR as..Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans
Journal of Allergy and Clinical Immunology
Oct 2012
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans
Background: Genome-wide association studies of asthma have implicated many genetic risk factors, with well-replicated associations at approximately 10 loci that account for only a small proportion of the genetic risk. Objectives: We aimed to identify additional asthma risk loci by performing an extensive replication..Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes
Journal of Allergy and Clinical Immunology
Oct 2012
Long-term safety of mepolizumab for the treatment of hypereosinophilic syndromes
Background: Hypereosinophilic syndromes (HESs) are chronic disorders that require long-term therapy to suppress eosinophilia and clinical manifestations. Corticosteroids are usually effective, yet many patients become corticosteroid refractory or develop corticosteroid toxicity. Mepolizumab, a humanized monoclonal..Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes
Journal of Allergy and Clinical Immunology
Oct 2012
Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes
Background: Both leukotriene D4 (LTD4) and methacholine bronchial provocation tests are measurements of airway responsiveness; however, their correlation and distinction remain unexplored. Objectives: We sought to compare the 2 tests and classify leukotriene-responsiveness subtypes in asthmatic patients. Methods: In..Efficacy and safety of a once-daily sublingual immunotherapy without escalation regimen in house dust mite–induced allergic rhinitis
International Forum of Allergy & Rhinology
Oct 2012
Efficacy and safety of a once-daily sublingual immunotherapy without escalation regimen in house dust mite–induced allergic rhinitis
Background: The conventional escalation regimen for sublingual immunotherapy (SLIT) in patients with allergic rhinitis has been proven to be safe and successful in reducing allergic symptoms. However, few studies compared the efficacy and safety between a conventional escalation regimen for SLIT and once-daily SLIT...Paranasal sinus cholesterol granuloma: systematic review of diagnostic and management aspects
International Forum of Allergy & Rhinology
Oct 2012
Paranasal sinus cholesterol granuloma: systematic review of diagnostic and management aspects
Background: Cholesterol granuloma (CG) is an expansile, cystic lesion most commonly observed in the temporal bone. CG is rarely encountered in the paranasal sinuses. Given its paucity in this region, the diagnostic and management aspects remain to be elucidated. Methods: Systematic review of the literature yielded 66..Intravenous tranexamic acid and intraoperative visualization during functional endoscopic sinus surgery: a double-blind randomized controlled trial
International Forum of Allergy & Rhinology
Oct 2012
Intravenous tranexamic acid and intraoperative visualization during functional endoscopic sinus surgery: a double-blind randomized controlled trial
Background: Bleeding during endoscopic sinus surgery (ESS) can hinder surgical progress and may be associated with increased complications. Tranexamic acid is an antifibrinolytic that is known to reduce operative bleeding. The current study was designed to assess the effect of adjunctive intravenous tranexamic acid on..Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations
International Forum of Allergy & Rhinology
Oct 2012
Topical therapies in the management of chronic rhinosinusitis: an evidence-based review with recommendations
Background: Topical therapies have become an integral component in the management plan for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based..Effect of oral administration with pravastatin and atorvastatin on airway hyperresponsiveness and allergic reactions in asthmatic mice
Annals of Allergy, Asthma & Immunology
Oct 2012
Effect of oral administration with pravastatin and atorvastatin on airway hyperresponsiveness and allergic reactions in asthmatic mice
Background: Asthma is characterized by airway hyperresponsiveness and remodeling. Pravastatin and atorvastatin are used clinically as cholesterol-lowering agents but also exhibit anti-inflammatory and immunomodulating properties. Objective: To investigate the therapeutic effect of oral statins on airway..Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species
Journal of Allergy and Clinical Immunology
Oct 2012
Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species
Signal transducer and activator of transcription (STAT) proteins are key components of the innate and adaptive immune responses to pathogenic microorganisms. Recent research on primary immunodeficiency disorders and the identification of patients carrying germline mutations in STAT1, STAT3, and STAT5B have highlighted..Systemic contact dermatitis to corticosteroids
Allergy
Oct 2012
Systemic contact dermatitis to corticosteroids
Background: Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic..Microarray evaluation of specific IgE to allergen components in elite athletes
Allergy
Oct 2012
Microarray evaluation of specific IgE to allergen components in elite athletes
Background: Allergic sensitization and diseases have been reported to have a very high and increasing prevalence in elite athletes. Over 80% of allergic athletes are poly-sensitized. Objective: This study aims at evaluating the potential diagnostic added value of a microarray technology (ImmunoCAP ISAC, Phadia AB [at..Staphylococcus aureus prevalence in allergic fungal rhinosinusitis vs other subsets of chronic rhinosinusitis with nasal polyps
International Forum of Allergy & Rhinology
Oct 2012
Staphylococcus aureus prevalence in allergic fungal rhinosinusitis vs other subsets of chronic rhinosinusitis with nasal polyps
Background: The pathogenesis of allergic fungal rhinosinusitis (AFRS) is thought to represent an immunological reaction to fungal antigens. Recent studies have implicated superantigens and non-immunoglobulin E (IgE)-mediated mechanisms in the development of AFRS. The objective of this study is to assess the prevalence..Sinonasal epithelial cells synthesize active vitamin D, augmenting host innate immune function
International Forum of Allergy & Rhinology
Oct 2012
Sinonasal epithelial cells synthesize active vitamin D, augmenting host innate immune function
Background: Vitamin D, long recognized for its role in bone metabolism and calcium homeostasis, has been increasingly shown to augment innate immunity. 1-α-Hydroxylase, the enzyme responsible for the synthesis of active vitamin D, has been shown to have extrarenal expression in multiple cell types, including airway..Systemic contact dermatitis to corticosteroids
Allergy
Oct 2012
Systemic contact dermatitis to corticosteroids
Background: Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic..Microarray evaluation of specific IgE to allergen components in elite athletes
Allergy
Oct 2012
Microarray evaluation of specific IgE to allergen components in elite athletes
Background: Allergic sensitization and diseases have been reported to have a very high and increasing prevalence in elite athletes. Over 80% of allergic athletes are poly-sensitized. Objective: This study aims at evaluating the potential diagnostic added value of a microarray technology (ImmunoCAP ISAC, Phadia AB [at..Maximal medical therapy for chronic rhinosinusitis: a survey of otolaryngology consultants in the United Kingdom
International Forum of Allergy & Rhinology
Oct 2012
Maximal medical therapy for chronic rhinosinusitis: a survey of otolaryngology consultants in the United Kingdom
Background: The management of chronic rhinosinusitis is based on a trial of “maximal medical therapy” before surgery is considered. Ear-Nose-Throat (ENT) UK consultant members were surveyed to determine the role and variability of UK-wide practices. Methods: A survey was posted to all ENT UK consultant members (n =..Staphylococcus aureus prevalence in allergic fungal rhinosinusitis vs other subsets of chronic rhinosinusitis with nasal polyps
International Forum of Allergy & Rhinology
Oct 2012
Staphylococcus aureus prevalence in allergic fungal rhinosinusitis vs other subsets of chronic rhinosinusitis with nasal polyps
Background: The pathogenesis of allergic fungal rhinosinusitis (AFRS) is thought to represent an immunological reaction to fungal antigens. Recent studies have implicated superantigens and non-immunoglobulin E (IgE)-mediated mechanisms in the development of AFRS. The objective of this study is to assess the prevalence..The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH)
International Forum of Allergy & Rhinology
Oct 2012
The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH)
Background: Sinonasal respiratory epithelial adenomatoid hamartoma (REAH) is a benign glandular proliferation with ciliated epithelium. Little is known about REAH, with only a few published case reports appearing since its original description in 1995. Classically described as an isolated polypoid lesion arising from..Clinical severity and epithelial endotypes in chronic rhinosinusitis
International Forum of Allergy & Rhinology
Oct 2012
Clinical severity and epithelial endotypes in chronic rhinosinusitis
Background: Chronic rhinosinusitis (CRS) is a heterogeneous disease defined by epithelial inflammation. The link between measures of traditional disease severity and markers of epithelial inflammation is poorly understood as prior research has focused on presence of polyps or degree of eosinophilia. The expression of 3..Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis
Journal of Allergy and Clinical Immunology
Oct 2012
Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis
Background: Platelet-activating factor (PAF) is an important mediator and correlates with anaphylaxis severity. How well PAF correlates with severity relative to histamine or tryptase is not known. Objective: To analyze the levels of PAF, histamine, and tryptase as a function of severity in patients with acute allergic..Short-acting β-agonist use and its ability to predict future asthma-related outcomes
Annals of Allergy, Asthma & Immunology
Oct 2012
Short-acting β-agonist use and its ability to predict future asthma-related outcomes
Background: Short-acting β-agonist (SABA) use is well established in predicting asthma events in adults. However, this predictive ability has yet to be established in a pediatric population together with an assessment of amount of use. Objective: To identify the number of SABA canisters that best predicts future..Correlation of Der p 2 T-cell responses with clinical characteristics of children allergic to house dust mite
Annals of Allergy, Asthma & Immunology
Oct 2012
Correlation of Der p 2 T-cell responses with clinical characteristics of children allergic to house dust mite
Background: An understanding of the mechanisms responsible for the development and maintenance of allergic inflammation and their clinical implications is needed to develop specific and successful treatment for allergy. Objectives: To characterize in vitro T-cell responses to Der p 2, one of the major allergens of..Dichlorophenol-containing pesticides and allergies: results from the US National Health and Nutrition Examination Survey 2005-2006
Annals of Allergy, Asthma & Immunology
Oct 2012
Dichlorophenol-containing pesticides and allergies: results from the US National Health and Nutrition Examination Survey 2005-2006
Background: Epidemiologic studies support the hypothesis that reduced microbial exposure in westernized societies promotes atopy. Dichlorophenols are widely used as pesticides and for chlorination of water. They have a strong bactericidal effect that could affect microflora in the environment. However, it is unknown..Warts and all: Human papillomavirus in primary immunodeficiencies
Journal of Allergy and Clinical Immunology
Oct 2012
Warts and all: Human papillomavirus in primary immunodeficiencies
Infection with human papillomavirus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in EVER1, EVER2, GATA2, CXCR4, and dedicator of cytokinesis..Distinct TLR-mediated pathways regulate house dust mite–induced allergic disease in the upper and lower airways
Journal of Allergy and Clinical Immunology
Oct 2012
Distinct TLR-mediated pathways regulate house dust mite–induced allergic disease in the upper and lower airways
Background: Allergic rhinitis (AR) and asthma are 2 entities of allergic airway diseases that frequently occur together, which is referred to as united airways. In contrast to this general concept, we hypothesized that innate immunity of the upper and lower airways is respectively distinctive, because the immunologic..The Asthma Disease Activity Score: A discriminating, responsive measure predicts future asthma attacks
Journal of Allergy and Clinical Immunology
Oct 2012
The Asthma Disease Activity Score: A discriminating, responsive measure predicts future asthma attacks
Background: Classifying asthma severity or activity has evolved, but there are no published weighted composite measures of asthma disease activity that account for the relative importance of the many individual clinical variables that are widely used. Objectives: We sought to develop a weighted and responsive measure..Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand
Journal of Allergy and Clinical Immunology
Oct 2012
Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand
Background: Recent studies revealed a critical role for thymic stromal lymphopoietin (TSLP) released from epithelial cells and OX40 ligand (OX40L) expressed on dendritic cells (DCs) in TH2 priming and polarization. Objectives: We sought to determine the importance of the TSLP-OX40L axis in neonatal respiratory..The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model
Journal of Allergy and Clinical Immunology
Oct 2012
The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model
Background: A diagnostic prediction model for peanut allergy in children was recently published, using 6 predictors: sex, age, history, skin prick test, peanut specific immunoglobulin E (sIgE), and total IgE minus peanut sIgE. Objectives: To validate this model and update it by adding allergic rhinitis, atopic..Epigenetic mechanisms and the development of asthma
Journal of Allergy and Clinical Immunology
Oct 2012
Epigenetic mechanisms and the development of asthma
Asthma is heritable, influenced by the environment, and modified by in utero exposures and aging; all of these features are also common to epigenetic regulation. Furthermore, the transcription factors that are involved in the development of mature T cells that are critical to the TH2 immune phenotype in asthmatic..Asthma Symptom Utility Index: Reliability, validity, responsiveness, and the minimal important difference in adult asthmatic patients
Journal of Allergy and Clinical Immunology
Oct 2012
Asthma Symptom Utility Index: Reliability, validity, responsiveness, and the minimal important difference in adult asthmatic patients
Background: The evaluation of asthma symptoms is a core outcome measure in asthma clinical research. The Asthma Symptom Utility Index (ASUI) was developed to assess the frequency and severity of asthma symptoms. The psychometric properties of the ASUI are not well characterized, and a minimal important difference (MID)..Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data
Journal of Allergy and Clinical Immunology
Sep 2012
Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data
Background: The atopic march hypothesis proposes that eczema precedes the development of asthma and allergic rhinitis. Objective: We sought to assess the evidence for a causal effect of infantile eczema on childhood hay fever, asthma, or both. Methods: We used parental reports on infantile eczema and childhood asthma..Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
Journal of Allergy and Clinical Immunology
Sep 2012
Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
Background: Adult patients with nasal polyps often have comorbid asthma, adding to the serious effect on the quality of life of these patients. Nasal polyps and asthma might represent a therapeutic challenge; inflammation in both diseases shares many features, such as airway eosinophilia, local IgE formation, and a TH2..IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years
Journal of Allergy and Clinical Immunology
Sep 2012
IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years
Background: IL10 encodes for IL-10, an important anti-inflammatory cytokine with pleiotropic effects. It is crucial for development of immune tolerance, downregulates expression of TH1 cytokines, and is relevant for T-cell regulation. Several IL10 single nucleotide polymorphisms (SNPs) were associated with inflammatory..Modeling asthma exacerbations through lung function in children
Journal of Allergy and Clinical Immunology
Sep 2012
Modeling asthma exacerbations through lung function in children
Background: Formal economic evaluation using a model-based approach is playing an increasingly important role in health care decision making. Objective: To develop a model by using an objective measure of lung function— prebronchodilator FEV1 as a percent of predicted (FEV1% predicted)—as the primary independent factor..Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis–based comparison
Journal of Allergy and Clinical Immunology
Sep 2012
Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis–based comparison
Background: Subcutaneous (SCIT) and sublingual (SLIT) immunotherapy are the 2 most prescribed routes for administering allergen-specific immunotherapy. They were shown to be effective in control of symptoms and in reducing rescue medication use in patients with allergic diseases, but their effectiveness has to be..Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies
Journal of Allergy and Clinical Immunology
Sep 2012
Birch pollen immunotherapy results in long-term loss of Bet v 1–specific TH2 responses, transient TR1 activation, and synthesis of IgE-blocking antibodies
Background: Early events of specific immunotherapy (SIT) are induction of allergen-specific IL-10–producing TR1 cells and production of IgG antibodies, but there is little knowledge about the long-term immune mechanisms responsible for sustained allergen tolerance. Objective: Bet v 1–specific immune responses of 16..Early interventional treatment with intranasal corticosteroids compared with postonset treatment in pollinosis
Annals of Allergy, Asthma & Immunology
Sep 2012
Early interventional treatment with intranasal corticosteroids compared with postonset treatment in pollinosis
Background: The usefulness of early interventional treatment (EIT) with intranasal corticosteroids (INSs) compared with postonset treatment (POT) has not been clarified. Objectives: To study the efficacy and safety of EIT with INSs compared with POT and placebo in Japanese cedar/cypress pollinosis. Methods: We designed..IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
Journal of Allergy and Clinical Immunology
Sep 2012
IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
Background: Allergen exposure at lung and gut mucosae can lead to aberrant TH2 immunity and allergic disease. The epithelium-associated cytokines thymic stromal lymphopoietin (TSLP), IL-25, and IL-33 are suggested to be important for the initiation of these responses. Objective: We sought to investigate the..Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production
Journal of Allergy and Clinical Immunology
Sep 2012
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production
Background: The exact pathogenesis of the pediatric disorder periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome is unknown. Objectives: We hypothesized that PFAPA might be due to dysregulated monocyte IL-1β production linked to genetic variants in proinflammatory genes. Methods:..Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma
Journal of Allergy and Clinical Immunology
Sep 2012
Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma
Background: Protectin D1 (PD1) is an anti-inflammatory and proresolving lipid mediator biosynthesized from the omega-3 fatty acid docosahexaenoic acid (DHA). Exogenous PD1 conferred protection against eosinophilic inflammation in animals with experimental asthma, although its endogenous cellular source and functions in..Neonatal vitamin D status and childhood peanut allergy: a pilot study
Annals of Allergy, Asthma & Immunology
Sep 2012
Neonatal vitamin D status and childhood peanut allergy: a pilot study
Background: Although a number of factors have been proposed to explain the increase in food allergy during the last decade, the possibility that vitamin D status may play a pathogenic role has received recent attention. Objective: To determine whether lower levels of neonatal 25-hydroxyvitamin D (25[OH]D) would be..Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema
Allergy
Sep 2012
Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema
Background: Hereditary angioedema is a rare autosomal dominant disease, and its correlation between genotype and phenotype seems not to exist. So far, there are very few studies on Chinese population. We aimed to establish a Chinese genetic database of hereditary angioedema and investigated the potential correlation..Environmental bacteria and childhood asthma
Allergy
Sep 2012
Environmental bacteria and childhood asthma
Background: We have previously found an inverse association of bacterial diversity with childhood asthma. It remains unclear whether certain bacteria account for the protective effect. Methods: The high variability of the bacterial 16S rRNA gene allows assessing diversity and specificity of bacterial communities by..Value of the clinical history in the diagnosis of urticaria/angioedema induced by NSAIDs with cross-intolerance
Clinical & Experimental Allergy
Sep 2012
Value of the clinical history in the diagnosis of urticaria/angioedema induced by NSAIDs with cross-intolerance
Background: Multiple NSAID-induced urticaria/angioedema is the most common manifestation of hypersensitivity reactions to NSAIDs. Diagnostic evaluation is based on the clinical history and a drug provocation test. Objective: To evaluate the role of the clinical history in the diagnosis of multiple NSAID-induced..Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test
Clinical & Experimental Allergy
Sep 2012
Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test
Background: Strict avoidance is the only accepted management for cow's milk (CM) allergy. CM oral immunotherapy (CM-OIT) is under investigation. Objectives: To evaluate long-term safety of CM-OIT. To identify clinical/immunological predictors of adverse events. Methods: Prospective longitudinal epidemiological..Mechanisms of Tolerance Induction in Allergic Disease: Integrating Current and Emerging Concepts
Clinical & Experimental Allergy
Sep 2012
Mechanisms of Tolerance Induction in Allergic Disease: Integrating Current and Emerging Concepts
The prevalence of atopy and allergic disease continues to escalate worldwide. Defining immune mechanisms that suppress the underlying Th2-driven inflammatory processes is critical for the rational design of new treatments to prevent or attenuate disease. Allergen immunotherapy has provided a useful framework for..Nonhistaminergic Angioedema: Focus on Bradykinin-Mediated Angioedema
Clinical & Experimental Allergy
Sep 2012
Nonhistaminergic Angioedema: Focus on Bradykinin-Mediated Angioedema
Angioedema is a result of increased vascular permeability, with subsequent extravasation of intravascular fluid into the surrounding tissues. Angioedema may be mediated by histamine, bradykinin, or other mediators. Histaminergic angioedema generally presents with urticaria and/or pruritus and will respond to..In silico prediction of Ara h 2 T cell epitopes in peanut allergic children
Clinical & Experimental Allergy
Sep 2012
In silico prediction of Ara h 2 T cell epitopes in peanut allergic children
Background: Despite the frequency and severity of peanut allergy, the only approved treatment is strict avoidance. Different types of immunotherapy with crude peanut extract are not universally effective and have been associated with relatively high adverse reaction rates. Objective: We sought to determine whether in..Validation of the modified allergic rhinitis and its impact on asthma (ARIA) severity classification in allergic rhinitis children: the PEDRIAL study
Allergy
Sep 2012
Validation of the modified allergic rhinitis and its impact on asthma (ARIA) severity classification in allergic rhinitis children: the PEDRIAL study
Background: A modified allergic rhinitis and its impact on asthma (ARIA) (m-ARIA) criterion to classify the severity of allergic rhinitis (AR) has recently been validated in both treated and untreated adult patients; however, such information in children is lacking. The aim of this study was to validate this m-ARIA..Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17
Journal of Allergy and Clinical Immunology
Sep 2012
Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17
Background: Studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic inflammation, but in vivo evidence for this phenotype in human asthma is lacking. Objective: To characterize the phenotype of lung macrophages from asthmatic..Fel d 1–derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: A randomized, placebo-controlled study
Journal of Allergy and Clinical Immunology
Sep 2012
Fel d 1–derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: A randomized, placebo-controlled study
Background: Allergic rhinoconjunctivitis is an increasingly common source of morbidity, with sensitivity to cats accounting for 10% to 15% of disease burden. Allergy to cats is also a major risk factor for the development of asthma. Objectives: We sought to probe the persistence of the treatment effect of a novel Fel d..Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency
Journal of Allergy and Clinical Immunology
Sep 2012
Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency
Background: Signals emanating from the antigen T-cell receptor (TCR) are required for T-cell development and function. The T lymphocyte–specific protein tyrosine kinase (Lck) is a key component of the TCR signaling machinery. On the basis of its function, we considered LCK a candidate gene in patients with combined..Thymic stromal lymphopoietin is induced by respiratory syncytial virus–infected airway epithelial cells and promotes a type 2 response to infection
Journal of Allergy and Clinical Immunology
Sep 2012
Thymic stromal lymphopoietin is induced by respiratory syncytial virus–infected airway epithelial cells and promotes a type 2 response to infection
Background: Respiratory viral infection, including respiratory syncytial virus (RSV) and rhinovirus, has been linked to respiratory disease in pediatric patients, including severe acute bronchiolitis and asthma exacerbation. Objective: The study examined the role of the epithelial-derived cytokine thymic stromal..Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma
Journal of Allergy and Clinical Immunology
Sep 2012
Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma
Background: Asthma is a chronic inflammatory disease characterized by airways hyperresponsiveness (AHR), reversible airflow obstruction, airway remodeling, and episodic exacerbations caused by air pollutants, such as particulate matter (PM; PM <2.5 μm in diameter [PM2.5]) and ozone (O3). Spleen tyrosine kinase (Syk),..Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma
Journal of Allergy and Clinical Immunology
Sep 2012
Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma
Background: Impaired immune response to viral infections in atopic asthmatic patients has been recently reported and debated. Whether this condition is present in childhood and whether it is affected by atopy per se deserves further investigation. Objective: We sought to investigate airway interferon production in..Safety, Efficacy and Pharmacokinetics of a New 10% Liquid Intravenous Immunoglobulin (IVIG) in Patients with Primary Immunodeficiency
Journal of Clinical Immunology
Aug 2012
Safety, Efficacy and Pharmacokinetics of a New 10% Liquid Intravenous Immunoglobulin (IVIG) in Patients with Primary Immunodeficiency
Introduction: An investigational 10% liquid intravenous immunoglobulin (IVIG) was studied in 63 patients with primary immunodeficiency (PID) at 15 study sites. Methods: Patients were treated every 3 or 4 weeks with 254–1029 mg/kg/infusion of IVIG. Results: Overall, Biotest-IVIG infusions were well tolerated. The..Impact of tobacco smoke on chronic rhinosinusitis: a review of the literature
International Forum of Allergy & Rhinology
Jun 2012
Impact of tobacco smoke on chronic rhinosinusitis: a review of the literature
Background: Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS). The objectives of this review are to summarize prior studies that describe the correlation between active smoking and secondhand smoke..Risk factors for development of chronic rhinosinusitis in patients with allergic rhinitis
International Forum of Allergy & Rhinology
May 2012
Risk factors for development of chronic rhinosinusitis in patients with allergic rhinitis
Background: Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition of the sinonasal cavity. CRS may be preceded by other sinonasal inflammatory diseases including allergic rhinitis (AR). It is unclear what factors may predispose patients with AR to develop CRS. Methods: We performed a retrospective..Risk factors for development of chronic rhinosinusitis in patients with allergic rhinitis
International Forum of Allergy & Rhinology
May 2012
Risk factors for development of chronic rhinosinusitis in patients with allergic rhinitis
Background: Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory condition of the sinonasal cavity. CRS may be preceded by other sinonasal inflammatory diseases including allergic rhinitis (AR). It is unclear what factors may predispose patients with AR to develop CRS. Methods: We performed a retrospective..The effect of augmented real-time image guidance on task workload during endoscopic sinus surgery
International Forum of Allergy & Rhinology
May 2012
The effect of augmented real-time image guidance on task workload during endoscopic sinus surgery
Background: Due to proximity to critical structures, the need for spatial awareness during endoscopic sinus surgery (ESS) is essential. We have developed an augmented, real-time image-guided surgery (ART-IGS) system that provides live navigational data and proximity alerts to the operating surgeon during ablation. We..Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis
International Forum of Allergy & Rhinology
May 2012
Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis
Background: Inflammatory dysfunction is considered an important part of chronic rhinosinusitis (CRS). Corticosteroid therapy has been widely used in CRS. Effective topical delivery has been previously problematic. The post–endoscopic sinus surgery (ESS) corridor is essential for adequate topical drug access. Devices..Chronic rhinosinusitis symptoms and computed tomography staging: improved correlation by incorporating radiographic density
International Forum of Allergy & Rhinology
Apr 2012
Chronic rhinosinusitis symptoms and computed tomography staging: improved correlation by incorporating radiographic density
Background: Traditional methods for staging of chronic rhinosinusitis (CRS) by computed tomography (CT) have not proven to be predictive of subjective reports of patients' symptoms. An objective measure of CRS severity that correlates well with patients' symptoms, particularly if available from CT data, would be a..Efficacy of the pedicled nasoseptal flap without cerebrospinal fluid (CSF) diversion for repair of skull base defects: incidence of postoperative CSF leaks
International Forum of Allergy & Rhinology
Apr 2012
Efficacy of the pedicled nasoseptal flap without cerebrospinal fluid (CSF) diversion for repair of skull base defects: incidence of postoperative CSF leaks
Background: The advances in endoscopic skull base surgery have led to the resection of increasingly larger cranial base lesions and the creation of larger skull base defects with the potential for increased postoperative high-flow cerebrospinal fluid (CSF) leaks. These concerns led to the development of the..Endonasal repair of septal perforations using a rotational mucosal flap and acellular dermal interposition graft
International Forum of Allergy & Rhinology
Apr 2012
Endonasal repair of septal perforations using a rotational mucosal flap and acellular dermal interposition graft
Background: The closure of nasal septal perforations can be challenging based on the etiology, location, and method of closure. We report on a novel method of closure for nasal septal perforations using a unilateral mucosal rotational flap and acellular dermal interposition graft. Methods: Twenty patients with nasal..Structured histopathology profiling of chronic rhinosinusitis in routine practice
International Forum of Allergy & Rhinology
Mar 2012
Structured histopathology profiling of chronic rhinosinusitis in routine practice
Background: Tissue eosinophilia in chronic rhinosinusitis (CRS) is a marker of inflammatory disorders recalcitrant to surgical intervention. Eosinophilic chronic rhinosinusitis (ECRS) is traditionally associated with asthma, polyps, aspirin sensitivity, high serum eosinophilia, and elevated immunoglobulin E (IgE)...IL-31 regulates differentiation and filaggrin expression in human organotypic skin models
The Journal of Allergy and Clinical Immunology
Dec 2011
IL-31 regulates differentiation and filaggrin expression in human organotypic skin models
Background: Atopic dermatitis (AD) is an inflammatory skin disease affecting 10% to 20% of children and 1% to 3% of adults in industrialized countries. Enhanced expression of IL-31 is detected in skin samples of patients with AD, but its physiological relevance is not known. Objective: We sought to determine the role..Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis
The Journal of Allergy and Clinical Immunology
Dec 2011
Dendritic cells from X-linked hyper-IgM patients present impaired responses to Candida albicans and Paracoccidioides brasiliensis
Background: Patients with X-linked hyper-IgM syndrome (X-HIGM) due to CD40 ligand (CD40L) mutations are susceptible to fungal pathogens; however, the underlying susceptibility mechanisms remain poorly understood. Objective: To determine whether monocyte-derived dendritic cells (DCs) from patients with X-HIGM exhibit..Association of polymorphisms in the promoter region of FCER1A gene with Atopic dermatitis, Chronic uticaria, Asthma and serum IgE levels in a Han Chinese population
Human Immunology
Dec 2011
Association of polymorphisms in the promoter region of FCER1A gene with Atopic dermatitis, Chronic uticaria, Asthma and serum IgE levels in a Han Chinese population
The high-affinity receptor for IgE plays a central role in allergy diseases. Previous studies have reported the association of variants in the proximal promoter of FCER1A with IgE levels as well as allergy disorders. Another promoter gene polymorphism that is located upstream of exon 1 has not been investigated. We..A protocol for risk stratification of patients with carboplatin-induced hypersensitivity reactions
The Journal of Allergy and Clinical Immunology
Nov 2011
A protocol for risk stratification of patients with carboplatin-induced hypersensitivity reactions
Background: Management of patients with carboplatin-induced hypersensitivity reactions (HSR) has been complicated by high false-negative rates of carboplatin skin test (ST) results. These patients might be at risk for future carboplatin-induced HSRs. In this article we identify a strategy to improve risk stratification..Toll-like receptor 4–, 7–, and 8–activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines
The Journal of Allergy and Clinical Immunology
Nov 2011
Toll-like receptor 4–, 7–, and 8–activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines
Background: Bruton tyrosine kinase (BTK) is a component of signaling pathways downstream from Toll-like receptors (TLRs) 2, 4, 7, 8, and 9. Previous work in BTK-deficient mice, cell lines, and cultured cells from patients with X-linked agammaglobulinemia (XLA) suggested defective TLR-driven cytokine production...Three novel alleles at HLA-DRB1 locus identified by Sequence Based Typing
Human Immunology
Nov 2011
Three novel alleles at HLA-DRB1 locus identified by Sequence Based Typing
We describe here the sequences of 3 HLA-DRB1 new variants officially named DRB1*03:05:03, DRB1*11:10:02, DRB1*14:86. These novel alleles have been detected in three Caucasoid individuals by sequence-based typing (SBT). The first allele and the second one are the result of a silent mutation, which does not imply any..The stimulation of an osteogenic response by classical monocyte activation.
Biomaterials
Aug 2011
The stimulation of an osteogenic response by classical monocyte activation.
The monocyte/macrophage system plays a central role in host defense, wound healing and immune regulation at biomaterial surfaces. Monocytes can be classically and alternatively activated, and can be stimulated differently in response to variations in biomaterial surface properties. In this study, human monocytes,..Proteomic analysis of psoriatic skin tissue for identification of differentially expressed proteins: Up-regulation of GSTP1, SFN and PRDX2 in psoriatic skin
International Journal of Molecular Medicine
Jul 2011
Proteomic analysis of psoriatic skin tissue for identification of differentially expressed proteins: Up-regulation of GSTP1, SFN and PRDX2 in psoriatic skin
Psoriasis is a chronic inflammatory skin disease, characterized by a combination of abnormal proliferation of keratinocytes, immunology and vascular proliferation. Proteomic analyses have revealed some clues regarding the pathogenesis of psoriasis. In the present study, we conducted an investigation of different..C-reactive protein (CRP): An important diagnostic and prognostic tool in nursing-home-associated pneumonia
Archives of Gerontology and Geriatrics
Mar 2011
C-reactive protein (CRP): An important diagnostic and prognostic tool in nursing-home-associated pneumonia
Pneumonia is the second most common infection in long term care (LTC) residents and is a leading cause of death from infection in those groups of patients. Atypical presentations and fewer presenting signs and symptoms in older patients complicate diagnosis and delay initiation of adequate treatment. The aim of this..
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