Haematology Medical Journal Abstracts
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PedsQL™ Sickle Cell Disease Module: Feasibility, Reliability, and Validity
Pediatric Blood & Cancer
Feb 2013
PedsQL™ Sickle Cell Disease Module: Feasibility, Reliability, and Validity
Background: Sickle cell disease (SCD) is an inherited chronic disease that is characterized by complications such as recurrent painful vaso-occlusive events that require frequent hospitalizations and contribute to early mortality. The objective of the study was to report on the initial measurement properties of the new..Validation of Variants in SLC28A3 and UGT1A6 as Genetic Markers Predictive of Anthracycline-Induced Cardiotoxicity in Children
Pediatric Blood & Cancer
Feb 2013
Validation of Variants in SLC28A3 and UGT1A6 as Genetic Markers Predictive of Anthracycline-Induced Cardiotoxicity in Children
Background: The use of anthracyclines as effective antineoplastic drugs is limited by the occurrence of cardiotoxicity. Multiple genetic variants predictive of anthracycline-induced cardiotoxicity (ACT) in children were recently identified. The current study was aimed to assess replication of these findings in an..Blood Component Recalls and Market Withdrawals: Frequency, Reasons, and Management in the United States
Transfusion Medicine Reviews
Feb 2013
Blood Component Recalls and Market Withdrawals: Frequency, Reasons, and Management in the United States
In a previous article, we reviewed the management of blood component recalls and withdrawals (G. Ramsey. Transfusion Med Rev 2004;18:36–45). Since then, US rates of recall and biological product deviation for blood components have improved significantly, particularly with regard to reduced recalls for donor infectious..Seek and You Shall Find—But Then What Do You Do? Cold Agglutinins in Cardiopulmonary Bypass and a Single-Center Experience With Cold Agglutinin Screening Before Cardiac Surgery
Transfusion Medicine Reviews
Feb 2013
Seek and You Shall Find—But Then What Do You Do? Cold Agglutinins in Cardiopulmonary Bypass and a Single-Center Experience With Cold Agglutinin Screening Before Cardiac Surgery
Cardiopulmonary bypass (CPB) during cardiac surgery can involve deliberate hypothermia of the systemic (22-36°C) and coronary circulations (as low as 8-12°C). Adverse sequelae of cold-active antibodies have been feared and reported under such conditions, and some centers thus elect to screen for cold agglutinins before..Birth order and transplant outcome in HLA-identical sibling stem cell transplantation – an analysis on behalf of the Center for International Blood and Marrow Transplantation (CIBMTR)
Biology of Blood and Marrow Transplantation
Feb 2013
Birth order and transplant outcome in HLA-identical sibling stem cell transplantation – an analysis on behalf of the Center for International Blood and Marrow Transplantation (CIBMTR)
Background: Allogeneic stem cell transplantation is the most effective treatment option for many hematological malignancies, but graft-versus-host-disease (GvHD) remains a major cause of treatment failure. Besides well established risk factors for the outcome of transplantation, recent single-center studies have..Defining Incidence, Risk Factors, and Impact on Survival of Central Line-Associated Blood Stream Infections Following Hematopoietic Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome
Biology of Blood and Marrow Transplantation
Feb 2013
Defining Incidence, Risk Factors, and Impact on Survival of Central Line-Associated Blood Stream Infections Following Hematopoietic Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome
Central line-associated blood stream infections (CLABSI) commonly complicate the care of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients following allogeneic stem cell transplantation (HCT). We developed a modified CLABSI (MCLABSI) definition which attempts to exclude pathogens usually acquired..Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia
Biology of Blood and Marrow Transplantation
Feb 2013
Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia
We evaluated the outcome of children and adolescents with acquired severe aplastic anemia (SAA) who received haploidentical hematopoietic stem cell transplantation (HHCT) within vitro T cell-depleted peripheral blood stem cells. Twelve patients with acquired SAA received a total of 15 HHCTs within vitro CD3-depleted..Impact Of Pretransplant Conditioning Regimens On Outcomes Of Allogeneic Transplantation For Chemotherapy-Unresponsisve Diffuse Large B-Cell Lymphoma And Grade-Iii Follicular Lymphoma
Biology of Blood and Marrow Transplantation
Feb 2013
Impact Of Pretransplant Conditioning Regimens On Outcomes Of Allogeneic Transplantation For Chemotherapy-Unresponsisve Diffuse Large B-Cell Lymphoma And Grade-Iii Follicular Lymphoma
Patients with chemorefractory non-Hodgkin lymphomas (NHL) generally have a poor prognosis. We used the observational database of the CIBMTR to study the outcome of 533 patients with refractory diffuse large B-cell lymphoma (DLBCL) or grade-III follicular lymphoma (FL-III) who underwent allogeneic transplantation..Dynamic Change and Impact of Myeloid Derived Suppressor Cells in Allogeneic Bone Marrow Transplantation in Mice
Biology of Blood and Marrow Transplantation
Feb 2013
Dynamic Change and Impact of Myeloid Derived Suppressor Cells in Allogeneic Bone Marrow Transplantation in Mice
Myeloid-derived suppressor cells (MDSCs) are a group of myeloid cells comprised of hematopoietic progenitor cells, immature macrophages, dendritic cells and granulocytes, which accumulate in inflammatory diseases and various cancers. Here, we investigated the dynamic changes and effects of MDSCs in graft-versus-host..Outcomes of related donor HLA-identical or HLA-haploidentical allogeneic blood or marrow transplantation for peripheral T-cell lymphoma
Biology of Blood and Marrow Transplantation
Jan 2013
Outcomes of related donor HLA-identical or HLA-haploidentical allogeneic blood or marrow transplantation for peripheral T-cell lymphoma
Background: The role of allogeneic blood or marrow transplantation (alloBMT) for peripheral T-cell lymphoma (PTCL) remains to be defined. There is growing interest in reduced-intensity conditioning (RIC) regimens and/or utilization of HLA-haploidentical (haplo) grafts given concerns about treatment-associated..Rituximab Maintenance Therapy Until Progression After Rituximab and Chemotherapy Induction in Patients With Follicular Lymphoma
Clinical Lymphoma Myeloma and Leukemia
Jan 2013
Rituximab Maintenance Therapy Until Progression After Rituximab and Chemotherapy Induction in Patients With Follicular Lymphoma
Introduction The PRIMA (Primary Rituximab and Maintenance) study established 2 years of maintenance rituximab (MR) as a standard of care for follicular lymphoma (FL) patients who achieve an objective response after induction chemotherapy. A 17% improvement in progression-free survival (PFS) compared with those who did..Abducted by the illness: A qualitative study of traumatic stress in individuals with acute leukemia
Leukemia Research
Jan 2013
Abducted by the illness: A qualitative study of traumatic stress in individuals with acute leukemia
Symptoms of traumatic stress are common in acute leukemia. The goal of the present qualitative study was to understand this traumatic stress, as perceived by patients. Participants were 43 patients with acute leukemia in Toronto, Canada. Participants were asked in serial interviews about their experience of diagnosis..High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
Leukemia Research
Jan 2013
High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m2 q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-risk..Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
Leukemia Research
Jan 2013
Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
Background: Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and..Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria
Leukemia Research
Jan 2013
Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria
Hairy cell leukemia (HCL) and hairy cell leukemia-variant (HCL-v) are rare diseases with overlapping clinico-pathological features. We performed flow cytometry analysis (FCM) of 213 cases (169 HCL, 35 HCL-v, 9 splenic marginal zone lymphoma (SMZL)), correlating results with available corresponding clinical and..Is immune escape via human leukocyte antigen expression clinically relevant in chronic lymphocytic leukemia? Focus on the controversies
Leukemia Research
Jan 2013
Is immune escape via human leukocyte antigen expression clinically relevant in chronic lymphocytic leukemia? Focus on the controversies
Changes in classical and non-classical human leukocyte antigen expression by tumor cells can play a critical role in the generation of tumor antigen-specific immune responses and can modulate the interactions of natural killer cells and T cell subpopulations with target cells. Recently, several studies have..Pertinence of the Sysmex XE-5000™ parameters: rule of slide review in a context of ‘normal’ lymphocyte count (defined from control and mantle cell lymphoma blood specimens)
International Journal of Laboratory Hematology
Dec 2012
Pertinence of the Sysmex XE-5000™ parameters: rule of slide review in a context of ‘normal’ lymphocyte count (defined from control and mantle cell lymphoma blood specimens)
Introduction: As most hematology cell analyzers, the different parameters of Sysmex XE-5000™ are little informative in the qualitative analysis of lymphoid cells, and especially when the lymphocyte count is below 4 × 109/L (i.e., ‘normal’). The aim of our study was to investigate whether some parameters and/or ‘flags’..Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting
International Journal of Laboratory Hematology
Dec 2012
Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting
Introduction: The CELL-DYN Emerald is a compact bench-top hematology analyzer that can be used for a three-part white cell differential analysis. To determine its utility for analysis of human and mouse samples, we evaluated this machine against the larger CELL-DYN Sapphire and Sysmex XT2000iV hematology analyzers...Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Leukemia Research
Nov 2012
Prognostic significance of flow cytometric minimal residual disease assessment after the first induction course in Chinese childhood acute myeloid leukemia
Flow cytometry based minimal residual disease (MRD) was evaluated for outcome prediction in childhood acute myeloid leukemia (AML). The median levels of MRD in relapsed and nonrelapsed patients were different after the first induction (0.64% vs. 0.18%, P=0.030). A cutoff level of ≥0.25% after the first course of..Stroma-dependent development of two dendritic-like cell types with distinct antigen presenting capability
Experimental Hematology
Nov 2012
Stroma-dependent development of two dendritic-like cell types with distinct antigen presenting capability
Novel APC have been described in murine spleen. Cells have a distinct CD11cloCD11bhiMHC-II-CD8α- phenotype as highly endocytic dendritic-like cells which cross-present antigen to CD8+ T cells but fail to activate CD4+ T cells. They are named ‘L-DC’ since they reflect cells produced in longterm spleen cultures (LTC-DC)...Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice
Experimental Hematology
Nov 2012
Plerixafor (AMD3100) induces prolonged mobilization of acute lymphoblastic leukemia cells and increases the proportion of cycling cells in the blood in mice
The CXCR4 antagonist Plerixafor (AMD3100) induces the rapid mobilization of hematopoietic stem and progenitor cells into the blood in mice and humans. AMD3100 similarly induces the mobilization of human acute lymphoblastic leukemia (ALL) cells into the blood in mice. In this study, the temporal response of pre-B ALL..Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple Myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules
Experimental Hematology
Nov 2012
Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple Myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules
Multiple myeloma (MM)-induced osteoclast (OC) formation is mainly due to an imbalance of the receptor activator of NF-kappa-B ligand (RANKL)/osteoprotegerin (OPG) ratio in favor of RANKL in the bone microenvironment and to the CCL3 production by MM cells. The purpose of the study was to investigate the effect of the..Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1 driven T-ALL
Experimental Hematology
Nov 2012
Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1 driven T-ALL
Activating mutations of NOTCH1 and deletion of the INK4A-ARF (CDKN2A) tumor suppressor locus are two of the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL). In a murine model of T-ALL induced by the intracellular domain of Notch1 (ICN1), the genetic interaction between ICN1 signaling..Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Leukemia Research
Nov 2012
Birth weight in offspring and leukaemia risk in parents—A nation-wide register-based cohort study from Denmark
Spurred by previous observations we assessed the relationship between offspring birth weight and parental leukaemia risk in a register-based investigation including 2.4 million parents of 2 million Danish children. Regardless of analytical approach, offspring birth weight was not associated with parental risk of..Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
Leukemia Research
Nov 2012
Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review
The main objective of this systematic review is to quantify and to summarize all studies that have included health-related quality of life (HRQOL) or, any other type of patient-reported outcomes (PROs), in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Nine papers were..Genetics of graft-versus-host disease: The major histocompatibility complex
Blood Reviews
Nov 2012
Genetics of graft-versus-host disease: The major histocompatibility complex
Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but the best characterized genetic system is that of the human major histocompatibility complex (MHC) located on chromosome 6. Among the..Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
Leukemia Research
Nov 2012
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms, in which a stem cell lesion induces an autonomous proliferative advantage. In addition to the JAK2V617 mutation several other mutations have been described. Recently chronic inflammation has been proposed as a..Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Leukemia Research
Nov 2012
Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3
Multiple myeloma (MM) is an incurable plasma cell malignancy, which causes a significant morbidity due to organ damage and bone tissue destruction. In recent years, novel drugs have become available for MM therapy thanks to a more deepened knowledge of this disease's pathogenesis. The perspective of employing targeted..Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
Leukemia Research
Nov 2012
Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
In vivo effects of the DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) upon the epigenome of acute myeloid leukemia (AML) patients are scarcely studied in primary blasts. Here, we sequentially assessed DNA methylation and transcriptome changes in myeloblasts of DAC-treated AML patients. DNA methylation changes..Pilot Study of Comprehensive Geriatric Assessment (CGA) In Allogeneic Transplant: CGA Captures a High Prevalence of Vulnerabilities in Older Transplant Recipients
Biology of Blood and Marrow Transplantation
Nov 2012
Pilot Study of Comprehensive Geriatric Assessment (CGA) In Allogeneic Transplant: CGA Captures a High Prevalence of Vulnerabilities in Older Transplant Recipients
Comprehensive geriatric assessment (CGA) is frequently used in oncology to measure the health status of older adults with cancer, but it has not been studied in allogeneic hematopoietic cell transplantation (HCT). We conducted a prospective pilot study of CGA in allogeneic HCT recipients aged ≥50 years to examine the..Treosulfan-Thiotepa-Fludarabine based Conditioning Regimen for Allogeneic Transplantation in patients with Thalassaemia Major: A Single Centre Experience from North India
Biology of Blood and Marrow Transplantation
Nov 2012
Treosulfan-Thiotepa-Fludarabine based Conditioning Regimen for Allogeneic Transplantation in patients with Thalassaemia Major: A Single Centre Experience from North India
Hematopoietic stem cell transplantation (HSCT) is the definite treatment for thalassemia major. A busulfan (Bu) and cyclophosphamide (Cy)–based regimen has been the standard myeloablative chemotherapy, but is associated with higher treatment-related toxicity, particularly in patients classified as high risk by the..The role of the mycobiome in human acute graft-versus-host disease
Biology of Blood and Marrow Transplantation
Nov 2012
The role of the mycobiome in human acute graft-versus-host disease
A role for gut bacteria in the pathogenesis of graft-versus-host disease (GVHD) has been firmly established; however, the role of Candida spp, which form part of the mycobiome, remains unknown. In a homogenous group of patients who underwent allogeneic stem cell transplantation (SCT), we found a significant impact of..Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes
Leukemia Research
Nov 2012
Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes
Dendritic cells (DC) are antigen-presenting cells that play a pivotal role in coordinating functions of the immune system. Previous studies suggest that bone marrow (BM) failure in myelodysplastic syndromes (MDS) may be in part immune-mediated, and that the high propensity for relapse may reflect decreased immune..Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment
Leukemia Research
Nov 2012
Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment
Peripheral T-cell lymphomas (PTCL) are a diverse group of rare non-Hodgkin lymphomas (NHL) that carry a poor prognosis and are in need of effective therapies. Alisertib (MLN8237) an investigational agent that inhibits Aurora A Ser/Thr kinase has shown activity in PTCL patients. Here we demonstrate that aurora A and B..Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes
Leukemia Research
Nov 2012
Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes
We have previously demonstrated that two prognostic features of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), mutant NRAS and over-expressing BCL-2, cooperate physically and functionally in vivo. Screening of MDS patient bone marrow (BM) identified NRAS:BCL-2 co-localization in 64% cases,..Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation
Leukemia Research
Nov 2012
Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation
Activating mutations of the c-kit gene are frequently found in CBF (core binding factor) leukemias. We evaluated the effect of tyrosine kinase inhibitor dasatinib in leukemic cell lines bearing or not c-kit mutations. Our data demonstrate that in the AML Kasumi-1 cell line, bearing the N822K c-kit mutation, dasatinib..HLA-G5 in the blood of leukemia patients and healthy individuals
Leukemia Research
Nov 2012
HLA-G5 in the blood of leukemia patients and healthy individuals
In this work we focused on analysis of HLA-G5 molecules in the blood of patients with B-CLL leukemia and healthy individuals. Using sandwich ELISA, we found total soluble HLA-G, represented by sHLA-G1 and HLA-G5 in most of B-CLL patients while HLA-G5 alone was present only in few cases in both groups. These results..Expression and significance of vascular endothelial growth factor A and C in leukemia central nervous system metastasis
Leukemia Research
Nov 2012
Expression and significance of vascular endothelial growth factor A and C in leukemia central nervous system metastasis
Metastasis to the central nervous system (CNS) is an obstacle for leukemia treatment, the mechanisms of which remain to be elucidated. VEGF-A and VEGF-C are suspected to participate in this process. Paired of cerebrospinal fluid (CSF) and serum samples were collected from leukemia and control cases. Levels of VEGF-A..Molecular characterization of chromosomal band 5p15.33: A recurrent breakpoint region in mantle cell lymphoma involving the TERT–CLPTM1L locus
Leukemia Research
Nov 2012
Molecular characterization of chromosomal band 5p15.33: A recurrent breakpoint region in mantle cell lymphoma involving the TERT–CLPTM1L locus
Secondary chromosomal aberrations may contribute to the development of a malignant phenotype in mantle cell lymphoma. Chromosomal band 5p15.33 represents a new recurrent breakpoint in B-cell malignancies. We present a molecular cytogenetic study of 8 mantle cell lymphoma (MCL) cell lines and 23 patients with MCL to..Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome
Leukemia Research
Nov 2012
Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome
Chromosomal translocations typically impair cell differentiation and often require secondary mutations for malignant transformation. However, the role of a primary translocation in the development of collaborating mutations is debatable. To delineate the role of leukemic translocation NUP98-HOXD13 (NHD13) in secondary..Identification of the genomic BCR-ABL1 fusion sequence from blood specimen stored on filter paper
Leukemia Research
Nov 2012
Identification of the genomic BCR-ABL1 fusion sequence from blood specimen stored on filter paper
Chronic myeloid leukaemia (CML) is characterized by the Philadelphia chromosome resulting in the BCR-ABL1 gene whose mRNA transcript detection is commonly used for diagnosis and monitoring of therapeutic response. However, in collected blood specimen degradation of mRNA has to be considered during storage and transport..Aberrant hypomethylation of SALL4 gene in patients with myelodysplastic syndrome
Leukemia Research
Nov 2012
Aberrant hypomethylation of SALL4 gene in patients with myelodysplastic syndrome
The abnormalities of SALL4 gene, which encodes a zinc-finger transcription factor and is essential for developmental events, have been found to be involved in tumorigenesis. In this study, we investigated the methylation status of the CpG island of SALL4 promoter region in myelodysplastic syndrome (MDS) using..Validation and proposals for a refinement of the WHO 2008 classification of myelodysplastic syndromes without excess of blasts
Leukemia Research
Nov 2012
Validation and proposals for a refinement of the WHO 2008 classification of myelodysplastic syndromes without excess of blasts
In 2008, the WHO proposed changes in the classification of MDS regarding RCUD and MDS unclassifiable. We validated these proposals by using 2032 patients of the Düsseldorf MDS Registry. 10% of the patients had RCUD and 6% MDS-U. Among patients with RCUD, only 9% had RN and 6% had RT. There was no correlation between..Health-related quality of life in chronic myeloid leukemia
Leukemia Research
Oct 2012
Health-related quality of life in chronic myeloid leukemia
The increased survival associated with treatments for CML emphasize the importance of understanding the HRQOL of newly diagnosed and previously treated CML patients with all phases of disease. Functional Assessment of Cancer Therapy-Leukemia results from a phase 3 and a phase 2 trial are reported for over 900 1st, 2nd,..A therapeutic vaccine using Salmonella-modified tumor cells combined with interleukin-2 induces enhanced antitumor immunity in B-cell lymphoma
Leukemia Research
Oct 2012
A therapeutic vaccine using Salmonella-modified tumor cells combined with interleukin-2 induces enhanced antitumor immunity in B-cell lymphoma
Therapeutic vaccination holds potential as complementary treatment for non-Hodgkin's lymphoma (NHL). B-NHL cells are antigen-presenting cells, but they cannot elicit proper antitumor responses because they lack expression of co-stimulatory molecules. Here, we report a novel approach to design improved whole tumor cell..Anti-phospholipid antibodies contribute to arteriosclerosis in patients with systemic lupus erythematosus through induction of tissue factor expression and cytokine production from peripheral blood mononuclear cells
Thrombosis Research
Dec 2011
Anti-phospholipid antibodies contribute to arteriosclerosis in patients with systemic lupus erythematosus through induction of tissue factor expression and cytokine production from peripheral blood mononuclear cells
Introduction: In systemic lupus erythematosus (SLE) patients, the prevalence of arteriosclerosis obliterans (ASO) is high despite a lack of common risk factors for ASO. The main objective of this study was to investigate a possible direct role of anti-phospholipid antibodies (aPLs), which are frequently detected in SLE..The pan-histone deacetylase inhibitor CR2408 disrupts cell cycle progression, diminishes proliferation and causes apoptosis in multiple myeloma cells
British Journal of Haematology
Dec 2011
The pan-histone deacetylase inhibitor CR2408 disrupts cell cycle progression, diminishes proliferation and causes apoptosis in multiple myeloma cells
In view of the fact that histone deacetylases (HDACs) are promising targets for myeloma therapy, we investigated the effects of the HDAC inhibitor CR2408 on multiple myeloma (MM) cells in vitro. CR2408 is a direct pan-HDAC inhibitor and inhibits all known 11 HDACs with a 50% inhibitory concentration (IC50) of 12 nmol/l..The hematopoietic cell transplantation comorbidity index is a predictor of early death and survival in adult acute myeloid leukemia patients
Leukemia Research
Dec 2011
The hematopoietic cell transplantation comorbidity index is a predictor of early death and survival in adult acute myeloid leukemia patients
The hematopoietic cell transplantation comorbidity index (HCT-CI) is predictive of early death and survival in elderly patients with acute myeloid leukemia (AML). The aim of this study was to determine the prognostic role of the HCT-CI for early death and survival in adult AML patients. In the single-center..Therapy-related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy
European Journal of Haematology
Nov 2011
Therapy-related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy
Therapy-related acute promyelocytic leukemia (t-APL) is a well-recognized form of APL for which the underlying etiology has been well characterized. The pathogenesis of de novo (dn-APL) remains unknown; but epidemiologic studies have consistently identified increased body mass index (BMI), younger age, and ethnicity as..Profiling of immune-related microRNA expression in human cord blood and adult peripheral blood cells upon proinflammatory stimulation
European Journal of Haematology
Nov 2011
Profiling of immune-related microRNA expression in human cord blood and adult peripheral blood cells upon proinflammatory stimulation
Objectives: Cord blood (CB) transplantation has advantages in terms of incidence and severity of acute graft-versus-host disease (GVHD), while it has disadvantages in terms of infection. Our aim is to elucidate the molecular mechanism underlying the immune response of CB-derived cells during acute GVHD and infection..Clot lysis time and the risk of myocardial infarction and ischaemic stroke in young women; results from the RATIO case–control study
British Journal of Haematology
Nov 2011
Clot lysis time and the risk of myocardial infarction and ischaemic stroke in young women; results from the RATIO case–control study
Reduced overall fibrinolytic capacity increases the risk of myocardial infarction (MI), as demonstrated in studies with predominantly male participants. We determined the influence of altered fibrinolysis on the risk of MI and ischaemic stroke (IS) in young women. The RATIO (Risk of Arterial Thrombosis In relation to..Immature reticulocyte fraction as a predictor of bone marrow recovery in children with acute lymphoblastic leukaemia on remission induction phase
Bangladesh Medical Research Council Bulletin
Sep 2011
Immature reticulocyte fraction as a predictor of bone marrow recovery in children with acute lymphoblastic leukaemia on remission induction phase
Immature reticulocyte fraction a new routine parameter in the hematology analyzer can give the idea of the earliest morphologic change of bone marrow recovery before other test become positive after chemotherapy. A prospective observational study was carried out in the Department of Clinical Pathology in collaboration..Platelet transfusions for patients with haematological malignancies: who needs them?
British Journal of Haematology
May 2011
Platelet transfusions for patients with haematological malignancies: who needs them?
The goal of platelet transfusions is to prevent severe and life-threatening bleeding in patients with thrombocytopenia. This aim needs to be balanced against the risks associated with platelet transfusions as well as the challenge of maintaining an adequate supply. This review summarizes the recent evidence regarding..Haematological malignancy: are patients appropriately referred for specialist palliative and hospice care? A systematic review and meta-analysis of published data
Palliative Medicine
Jan 2011
Haematological malignancy: are patients appropriately referred for specialist palliative and hospice care? A systematic review and meta-analysis of published data
Haematological malignancies are complex diseases, affecting the entire age spectrum, and having marked differences in presentation, treatment, progression and outcome. Patients have a significant symptom burden and despite treatment improvements for some sub-types, many patients die from their disease. We carried out a..
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