Short Form 36-Item Health Survey test result on the empty nest elderly in China: A meta-analysisThe aim of this study was to evaluate the quality of life of the empty nest elderly in China using meta-analytic techniques. Electronic databases were searched for studies concerning the quality of life of the empty nest elderly published before December 2011. Pooled weighted mean difference (WMD) and 95% confidence..
Determinants of emergency medical utilization among the elderly population in Taiwan: A national longitudinal cohort study
Determinants of emergency medical utilization among the elderly population in Taiwan: A national longitudinal cohort studyThe aim of this study was to evaluate the potential determinants for emergency medical utilization by elderly patients in Taiwan. The data were drawn from the ‘Survey of Health and Living Status of the Elderly in Taiwan’, a population-based, longitudinal study of a nationally representative random sample of older..
Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages
Neurobiology of Aging
Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stagesAberrant complement activation is known to exacerbate the pathology in a spectrum of degenerative diseases of aging. We previously reported that aurin tricarboxylic acid (ATA) is an orally effective agent which prevents formation of the membrane attack complex of complement. It inhibits C9 attachment to tissue bound..
Neurobiology of Aging
Mapping creatinine- and cystatin C-related white matter brain deficits in the elderlyPoor kidney function is associated with increased risk of cognitive decline and generalized brain atrophy. Chronic kidney disease impairs glomerular filtration rate, and this deterioration is indicated by elevated blood levels of kidney biomarkers such as creatinine and cystatin C. Here we hypothesized that impaired..
Muscle strength is the main associated factor of physical performance in older adults with knee osteoarthritis regardless of radiographic severity
Muscle strength is the main associated factor of physical performance in older adults with knee osteoarthritis regardless of radiographic severityThe aim of the study is to compare factors associated with physical performance in older individuals with severe knee osteoarthritis and those with less-severe osteoarthritis. This is an ancillary cross-sectional study to a population-based cohort study focusing on Koreans age 65 years or older. The analysis included..
Neurobiology of Aging
APOE and neuroenergetics: an emerging paradigm in Alzheimer's diseaseAPOE is the major known genetic risk factor for late-onset Alzheimer's disease. Though relationships between APOE-encoded apolipoprotein E and β-amyloid are increasingly well described, mounting evidence supports wide-ranging effects of APOE on the brain. Specifically, APOE appears to affect brain network activity and..
Neurobiology of Aging
Lower cognitive reserve in the aging human immunodeficiency virus-infected brainMore HIV-infected individuals are living longer; however, how their brain function is affected by aging is not well understood. One hundred twenty-two men (56 seronegative control [SN] subjects, 37 HIV subjects with normal cognition [HIV+NC], 29 with HIV-associated neurocognitive disorder [HAND]) performed..
Neurobiology of Aging
Matrix metalloproteinase-12 contributes to neuroinflammation in the aged brainDuring aging the brain displays an increased proinflammatory status, which is associated with the pathogenesis of aging-related diseases such as Alzheimer's and Parkinson diseases. Matrix metalloproteinases (MMPs) facilitate the migration of inflammatory cells in tissues and modulate their inflammatory activity. In..
Neurobiology of Aging
Orally bioavailable small molecule drug protects memory in Alzheimer's disease modelsOligomers of beta-amyloid (Aβ) are implicated in the early memory impairment seen in Alzheimer's disease before to the onset of discernable neurodegeneration. Here, the capacity of a novel orally bioavailable, central nervous system-penetrating small molecule 5-aryloxypyrimidine, SEN1500, to prevent cell-derived (7PA2..
Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease
Neurobiology of Aging
Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's diseaseRecent evidence from cross-sectional in vivo imaging studies suggests that atrophy of the cholinergic basal forebrain (BF) in Alzheimer's disease (AD) can be distinguished from normal age-related degeneration even at predementia stages of the disease. Longitudinal study designs are needed to specify the dynamics of BF..
Insufficient Deep-Colored Vegetable Intake Is Associated With Higher Fragility Fracture Rate in Postmenopausal Taiwanese Women
Insufficient Deep-Colored Vegetable Intake Is Associated With Higher Fragility Fracture Rate in Postmenopausal Taiwanese WomenBackground: Osteoporosis-related fragility fracture is a major health issue in older adults. This study has been developed to investigate the relationship of lifestyle factors with fragility fracture prevalence in postmenopausal Taiwanese women. Methods: A total of 1050 postmenopausal women with a mean age of 66.7±8.6..
Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer’s disease
Neurobiology of Aging
Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer’s diseasePreviously, we reported a Ca2+/calmodulin (CaM)-dependent impairment of apoptosis induced by serum deprivation in Alzheimer’s disease (AD) lymphoblasts. These cell lines showed downregulation of extracellular signal-regulated kinase (ERK)1/2 activity and elevated content of p21 compared with control cells. The aim of..
Neurobiology of Aging
Supportive evidence for 11 loci from genome-wide association studies in Parkinson's diseaseGenome-wide association studies have identified a number of susceptibility loci in sporadic Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded the list of proposed association signals. We performed a case-control replication study in a Scandinavian population, analyzing samples from..
Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly
Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderlyPrognostic values of N-terminal pro-brain natriuretic peptide (NT-proBNP) in myriad diseases have been studied. During the natural progression of atherosclerotic renal artery disease (ARVD) changes of NT-proBNP levels and its significance is not understood. A prospective longitudinal follow-up study was conducted among..
Gender differences in factors influencing sexual satisfaction in Korean older adultsThis study investigates the sex lives of Korean older adults (i.e., those over 60 years) and attempts to identify gender-related factors influencing sexual satisfaction. It used data from the 2008 Korean National Survey on Older Adults conducted by the Ministry of Health, Welfare, and Families. Of the 15,146..
Change in sense of coherence (SOC) and symptoms of depression among old non-demented persons 12 months after hospitalization
Change in sense of coherence (SOC) and symptoms of depression among old non-demented persons 12 months after hospitalizationWe studied whether SOC of older adults (≥65 years) without cognitive impairment had changed 1-year after medical hospitalization (T2) and to examine what factors were associated with the change. At baseline (T1) and (T2), the 13-item version of the SOC scale assessed coping, and the Hospital Anxiety and Depression..
Correlation between moderate daily physical activity and neurocognitive variability in healthy elderly people
Correlation between moderate daily physical activity and neurocognitive variability in healthy elderly peopleRecent studies have reported that moderate physical activity in daily life contributes to maintenance of a proper state of cognitive function in elderly individuals. The present study investigated the validity of correlations between moderate physical activity and cognitive function using more objective and detailed..
Grip strength in a cohort of older medical inpatients in Malaysia: A pilot study to describe the range, determinants and association with length of hospital stay
Grip strength in a cohort of older medical inpatients in Malaysia: A pilot study to describe the range, determinants and association with length of hospital stayGrip strength is a marker of sarcopenia, the age-related decline in muscle mass and function, and has been little researched in Asian populations. We aimed to describe the feasibility and acceptability of measuring grip strength in hospitalized, older people in Malaysia and to explore its range, determinants and..
Homebound status increases death risk within two years in the elderly: Results from a national longitudinal survey
Homebound status increases death risk within two years in the elderly: Results from a national longitudinal surveyHomebound status is associated with poorer physical and mental health, as well as disability in the elderly. We aimed to examine the prevalence and the role of homebound status on mortality in a representative sample of the French non-institutionalized population. This study included 7497 people aged 65 and over who..
History of depression prior to Alzheimer's disease and vascular dementia verified post-mortemThe aim of this study was to analyze the medical history, with regards to previous remote depression, in patients with neuropathologically verified Alzheimer's disease (AD), vascular dementia (VaD) and mixed AD/VaD. The 201 patients included (115 AD, 44 VaD and 42 mixed AD/VaD) had been referred to the..
Health status and associated factors among the community-dwelling elderly in ChinaThe objective of this study was to evaluate the health status and associated factors of the elderly Chinese population. A cross-sectional survey was administered to 849 elderly people aged 60 years and over living in a certain district of Nanjing, China. A health rating scale based on the characteristics of the elderly..
Is increased red cell distribution width (RDW) indicating the inflammation in Alzheimer's disease (AD)?
Is increased red cell distribution width (RDW) indicating the inflammation in Alzheimer's disease (AD)?Increasing evidence indicates that inflammation has a substantial role in the pathogenesis and progression of AD. RDW, a measure of heterogeneity in the size of circulating erythrocytes, is associated with inflammatory markers in many numerous diseases. Present study was undertaken to assess the interrelationships..
Associations between sex hormones and cognitive and neuropsychiatric manifestations in vascular dementia (VaD)
Associations between sex hormones and cognitive and neuropsychiatric manifestations in vascular dementia (VaD)Although numerous studies have been carried out to determine the effects of sex hormones on Alzheimer's disease (AD), little is known about the associations between sex hormones and VaD. The aim of this study was to compare serum sex hormone levels between VaD patients and normal controls, and to further determine the..
Deviation of innate circadian period from 24 hours reduces longevity in miceThe variation of individual life spans, even in highly inbred cohorts of animals and under strictly controlled environmental conditions, is substantial and not well understood. This variation in part could be due to epigenetic variation, which later affects the animal’s physiology and ultimately longevity...
High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer’s disease
High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer’s diseaseAlzheimer’s disease (AD) is a progressive neurodegenerative disease that impairs mnesic functions. The histopathology of the disease is manifested by the accumulation of intracellular β-amyloid (Aβ) and subsequent formation of neuritic plaques as well as the presence neurofibrillary tangles in specific brain regions..
Identifying cognitive dysfunction using the nurses’ rapidly clinical judgment in elderly inpatientsBackground/Purpose: The aim of this study was to examine the relationship between nurses’ clinical judgment on cognitive function by fall risk assessment and mini-mental state examination (MMSE) scores in elderly inpatients. Methods: We studied 61 consecutive hospitalized patients who received both comprehensive..
Strength prior to endurance intra-session exercise sequence optimizes neuromuscular and cardiovascular gains in elderly men
Strength prior to endurance intra-session exercise sequence optimizes neuromuscular and cardiovascular gains in elderly menThis study investigated the effects of different intra-session exercise sequences in the cardiovascular and neuromuscular adaptations induced by concurrent training in elderly. Twenty-six healthy elderly men (64.7 ± 4.1 years), were randomly placed into two concurrent training groups: strength training prior to (SE, n..
Eight-point Compass Rose Underlay Technique in 72 Consecutive Elderly Patients with Large Incisional Hernia
Eight-point Compass Rose Underlay Technique in 72 Consecutive Elderly Patients with Large Incisional HerniaBackground: Repair of incisional hernia (IH) in the elderly is a challenge for the surgeon. Primary closure is preferable but is not always possible because of high recurrence rates of IH repaired without a prosthesis and/or possible respiratory and cardiovascular complications due to extreme tension of the margins. We..
Ageing and Society
How the lifecycle hypothesis explains volunteering during retirementWe suggest two supplements to Franco Modigliani's lifecycle model in order to explain why people who have retired from paid work choose either to start volunteering or increase the amount of time they devote to volunteer work. First, total consumption consists of both the material and immaterial products of work. While..
Systematic review of services providing information and/or advice to people with dementia and/or their caregivers
Systematic review of services providing information and/or advice to people with dementia and/or their caregiversBackground: Information is a key part of service provision to people with dementia and their carers, but there is no systematic review of the evidence. This study aimed to determine whether information services confer significant benefit for quality of life, neuropsychiatric symptoms and carer burden. Method: A..
Diagnostic accuracy of a new instrument for detecting cognitive dysfunctionBackground: Effective screening of cognitive disorders is limited by psychometric and practical properties of available instruments. The Brief Cognitive Screen (BCS) was developed to improve sensitivity and overall diagnostic accuracy of case detection for cognitive dysfunction in a quick and convenient format...
Malnutrition in an elderly demented population living at homeMalnutrition is a frequent complication for elderly demented patients even if they live at their own home with the assistance of a caregiver. The present study evaluates nutritional characteristics of a population of 130 non-institutionalized demented patients. The results show that the mini nutritional assessment..
Allergic rhinitis (AR) in geriatric patientsAllergic rhinitis (AR) can be defined as an inflammatory disease of the nose and the paranasal sinuses, characterized by a specific IgE-mediated hypersensitivity reaction. The aim of this study was to evaluate the correlation between the symptoms of AR and the prick test results in geriatric patients presenting with..
How family support affects physical activity (PA) among middle-aged and elderly people before and after they suffer from chronic diseases
How family support affects physical activity (PA) among middle-aged and elderly people before and after they suffer from chronic diseasesThe more support elderly people have from their family, the less likely they are to suffer from chronic diseases. The objective of this study is to investigate how family support affects the PA middle-aged and elderly people engage in before and after they suffer from chronic diseases. We interviewed 428 middle-aged..