Gastroenterology Medical Journal Abstracts
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Prospective antibody case finding of coeliac disease in type-1 diabetes children: need of biopsy revisited
Acta Paediatrica
Jan 2013
Prospective antibody case finding of coeliac disease in type-1 diabetes children: need of biopsy revisited
Aim: To evaluate whether coeliac disease (CD) can be diagnosed by measuring autoantibodies without small-intestinal mucosal biopsies in children with type 1 diabetes. Methods: Case finding of CD was undertaken in 181 consecutive IgA-competent children with type 1 diabetes using transglutaminase 2 (TG2) and endomysial..Placental Transfer of Anti-Tumor Necrosis Factor Agents in Pregnant Patients with Inflammatory Bowel Disease
Clinical Gastroenterology and Hepatology
Nov 2012
Placental Transfer of Anti-Tumor Necrosis Factor Agents in Pregnant Patients with Inflammatory Bowel Disease
Background & Aims: Some women with inflammatory bowel disease (IBD) require therapy with tumor necrosis factor (TNF) antagonists during pregnancy. It is not clear whether these drugs are transferred to the fetus, via the placenta, and then cleared, or whether structurally different TNF antagonists have different rates..Association between Sex Hormones and Colorectal Cancer Risk in Men and Women
Clinical Gastroenterology and Hepatology
Nov 2012
Association between Sex Hormones and Colorectal Cancer Risk in Men and Women
Background & Aims: There is observational and clinical evidence that indicate that sex hormones affect development of colorectal cancer (CRC) in men and women. However, the relationship between endogenous sex hormone levels and CRC is unclear. Methods: We collected data on lifestyle, medical history, and diet etc...Proton Pump Inhibitors Reduce the Risk of Neoplastic Progression in Patients with Barrett’s Esophagus
Clinical Gastroenterology and Hepatology
Nov 2012
Proton Pump Inhibitors Reduce the Risk of Neoplastic Progression in Patients with Barrett’s Esophagus
Background & Aims: Acid exposure contributes to the development of Barrett's esophagus (BE) and its progression toward esophageal adenocarcinoma. Patients with BE are frequently treated with acid suppressants, but it is unclear whether these prevent the development of BE-related cancer. We investigated therefore..Mutant TP53 in Duodenal Samples of Pancreatic Juice from Patients with Pancreatic Cancer or High-Grade Dysplasia
Clinical Gastroenterology and Hepatology
Nov 2012
Mutant TP53 in Duodenal Samples of Pancreatic Juice from Patients with Pancreatic Cancer or High-Grade Dysplasia
Background & Aims: Imaging tests can identify patients with pancreatic neoplastic cysts but not microscopic dysplasia. We investigated wither mutant TP53 can be detected in duodenal samples of secretin-stimulated pancreatic juice, and whether this assay can be used to screen for high-grade dysplasia and invasive..Role of microsatellite instability in the management of colorectal cancers
Digestive and Liver Disease
Nov 2012
Role of microsatellite instability in the management of colorectal cancers
Microsatellite instability is the consequence of a deficient mismatch repair system. It has a key role in the diagnostic strategy of Lynch syndrome, where tumours are all characterized by the presence of this phenotype. Microsatellite instability is therefore essential in the selection of colorectal cancer patients in..Anti-TNF-alpha treatments and obstructive symptoms in Crohn's Disease: A prospective study
Digestive and Liver Disease
Nov 2012
Anti-TNF-alpha treatments and obstructive symptoms in Crohn's Disease: A prospective study
Background: The development of symptomatic strictures in Crohn's Disease after anti-Tumour Necrosis Factor-α antibodies is undefined. Aim: To assess, in a prospective longitudinal study, the frequency of sub/obstructions in Crohn's Disease patients after treatment with Infliximab or Adalimumab. Changes of small bowel..Sixty- versus thirty-seconds papillary balloon dilation after sphincterotomy for the treatment of large bile duct stones: A randomized controlled trial
Digestive and Liver Disease
Nov 2012
Sixty- versus thirty-seconds papillary balloon dilation after sphincterotomy for the treatment of large bile duct stones: A randomized controlled trial
Background: Endoscopic biliary sphincterotomy followed by endoscopic papillary balloon dilation is a promising method for large stones. However, there are no data on the optimal duration of papillary balloon dilation after a biliary sphincterotomy. Aims: To compare the effectiveness and complications of the endoscopic..Diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small-bowel disease: Results of the Italian multicentre study
Digestive and Liver Disease
Nov 2012
Diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small-bowel disease: Results of the Italian multicentre study
Background: Limited data are available on the clinical impact of single balloon enteroscopy. Aims: To evaluate the diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small bowel disease. Methods: Data on patients with suspected small bowel disease based on non-invasive imaging,..Albumin Infusion Improves Outcomes of Patients with Spontaneous Bacterial Peritonitis: A Meta-Analysis of Randomized Trials
Clinical Gastroenterology and Hepatology
Nov 2012
Albumin Infusion Improves Outcomes of Patients with Spontaneous Bacterial Peritonitis: A Meta-Analysis of Randomized Trials
Background & Aims: Renal impairment increases mortality among patients with spontaneous bacterial peritonitis (SBP), despite administration of non-nephrotoxic antibiotics. Albumin infusion has been reported to reduce renal impairment and mortality in patients with SBP. We performed a meta-analysis of randomized..Predictive factors for an uncomplicated long-term course of Crohn's disease: A retrospective analysis
Journal of Crohn's and Colitis
Nov 2012
Predictive factors for an uncomplicated long-term course of Crohn's disease: A retrospective analysis
Background: Predictive factors for a mild course of Crohn's disease (CD) may have therapeutic consequences, but as yet have not been identified. Aims: To identify baseline factors that predict mild CD and design a predictive scoring system. Methods: A retrospective, multicenter study of newly diagnosed CD patients..Achievement of deep remission during scheduled maintenance therapy with TNFα-blocking agents in IBD
Journal of Crohn's and Colitis
Nov 2012
Achievement of deep remission during scheduled maintenance therapy with TNFα-blocking agents in IBD
Background and Aims: Deep remission, meaning clinical remission with mucosal healing (MH), with anti-tumor necrosis factor-alpha (TNF-α) agents is a new target for therapy in inflammatory bowel disease (IBD). Our aim was to study how often patients on TNF-α blocking therapy actually achieve deep remission. Methods: The..Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease
Journal of Crohn's and Colitis
Nov 2012
Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease
Background: Metabolic risk factors are associated with non-alcoholic fatty liver disease (NAFLD), but they are less frequent in inflammatory bowel disease (IBD). Aim: This study evaluates the frequency of NAFLD and its risk factors among IBD patients including anti-TNF-α therapy. Methods: IBD patients who underwent..A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol
Journal of Crohn's and Colitis
Nov 2012
A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol
Background and Aims: A skewed thiopurine metabolism is a phenomenon associated with both poor treatment response and toxicity. Our aim was to evaluate the frequency of this phenomenon and the relationship to thiopurine methyltransferase (TPMT) function. Methods: All thiopurine metabolite measurements in adult patients..Symptomatic duodenal Crohn's disease: Is strictureplasty the right choice?
Journal of Crohn's and Colitis
Nov 2012
Symptomatic duodenal Crohn's disease: Is strictureplasty the right choice?
Primary duodenal localization of Crohn's disease (CD) is rare. Medical therapy can control symptoms, but surgery is required when progressive obstructive symptoms occur. Surgical options include bypass, resection, or strictureplasty, but it is still not clear which should be the treatment of choice. Reviewing the..Beneficial effect of splenic artery ligation on bacterial translocation after major liver resection in rats
Digestive and Liver Disease
Nov 2012
Beneficial effect of splenic artery ligation on bacterial translocation after major liver resection in rats
Objective: In major liver resection, bacterial translocation appears to be an important mechanism in the pathogenesis of spontaneous infection. This study was designed to investigate the effects of splenic artery ligation on bacterial translocation after major liver resection. Materials and methods: Rats were divided..Long-term outcome after extensive intestinal resection for chronic radiation enteritis
Digestive and Liver Disease
Nov 2012
Long-term outcome after extensive intestinal resection for chronic radiation enteritis
Introduction: Management of chronic radiation enteritis is often controversial, particularly due to the risk of short bowel syndrome. Methods: One hundred and seven chronic radiation enteritis patients with short bowel syndrome were studied retrospectively between 1980 and 2009. Survival and home parenteral nutrition..The Membrane-Bound Mucin Muc1 Regulates Th17-Cell Responses and Colitis in Mice
Gastroenterology
Dec 2011
The Membrane-Bound Mucin Muc1 Regulates Th17-Cell Responses and Colitis in Mice
Background & Aims: T helper (Th) 17 cells produce the effector cytokine interleukin (IL)-17, along with IL-22, which stimulates colonic epithelial cells to produce a membrane-bound mucin, Muc1. Muc1 is a component of the colonic mucus, which functions as a lubricant and a physiological barrier between luminal contents..Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin activity in Colon Cancer Cells
Gastroenterology
Dec 2011
Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin activity in Colon Cancer Cells
Background & Aims: The intestine-specific homeobox transcription factor Cdx2 is an important determinant of intestinal identity in the embryonic endoderm and regulates the balance between proliferation and differentiation in the adult intestinal epithelium. Human colon tumors often lose Cdx2 expression, and..Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation
Journal of Hepatology
Dec 2011
Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation
Background & aims: Oxaliplatin-based chemotherapy for colorectal liver metastases (CRLM) can result in vascular liver lesions such as sinusoidal dilatations. Physiopathology remains unclear and variability between patients suggests that there is individual susceptibility. A better understanding of the molecular..EUS-Guided Biliary Drainage
Gastroenterology Research and Practice
Nov 2011
EUS-Guided Biliary Drainage
The echoendoscopic biliary drainage is an option to treat obstructive jaundices when ERCP drainage fails. These procedures compose alternative methods to the side of surgery and percutaneous transhepatic biliary drainage, and it was only possible by the continuous development and improvement of echoendoscopes and..Heterogeneity in tumor cell energetic metabolome at different cell cycle phases of human colon cancer cell lines
Metabolomics
Nov 2011
Heterogeneity in tumor cell energetic metabolome at different cell cycle phases of human colon cancer cell lines
In this present study, the efficacy of metabolomics as a tool for tumor cell energetics for in vitro cell cultures was demonstrated with full competence for the first time by elucidating the anabolic and energy-yielding segments of glycolysis and glutaminolysis, which constitute a part of energy metabolism in tumor..TWIST1 Promoter Methylation in Primary Colorectal Carcinoma
Pathology and Oncology Research
Nov 2011
TWIST1 Promoter Methylation in Primary Colorectal Carcinoma
TWIST1 gene, a transcription factor that belongs to the family of basic helix–loop–helix proteins, has been related to tumor progression and metastasis in different cancers. The aim of our study was to investigate TWIST1 promoter methylation in patients with primary colorectal carcinoma and determine its correlation..Hepatitis E virus infection in patients infected with the human immunodeficiency virus
Journal of Medical Virology
Aug 2011
Hepatitis E virus infection in patients infected with the human immunodeficiency virus
Hepatitis E virus (HEV) is a newly-identified causative agent of acute and chronic hepatitis in severely immunocompromized patients. The present study sought to assess the prevalences of past, recent, on-going, and chronic HEV infections in patients infected with human immunodeficiency virus (HIV) in Marseille,..Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients
International Journal of Cancer
Mar 2011
Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients
In the majority of colorectal cancers (CRCs) under clinical suspicion for a hereditary cause, the disease-causing genetic factors are still to be discovered. To identify such genetic factors we stringently selected a discovery cohort of 41 CRC index patients with microsatellite-stable tumors. All patients were below 40..A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
International Journal of Cancer
Mar 2011
A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135..
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