Eye Health and Disorders Medical Journal Abstracts
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Efficacy and safety of collagen matrix implants in phacotrabeculectomy, and comparison with mitomycin C augmented phacotrabeculetcomy at one year
Clinical & Experimental Ophthalmology
Dec 2012
Efficacy and safety of collagen matrix implants in phacotrabeculectomy, and comparison with mitomycin C augmented phacotrabeculetcomy at one year
Background: To assess the efficacy and safety of collagen matrix implant (Ologen TM) in phacotrabeculectomy surgeries in patients with primary glaucoma. Design: Prospective, non-randomized, comparative study. Participants: Sixty-six Asian patients undergoing phacotrabeculectomy. Methods: One eye of 33 consecutive..Is pre-operative ciliary body and iris anatomical configuration a predictor of malignant glaucoma development?
Clinical & Experimental Ophthalmology
Dec 2012
Is pre-operative ciliary body and iris anatomical configuration a predictor of malignant glaucoma development?
Background: To investigate anatomic configuration of ciliary body and iris, using ultrasound biomicroscopy (UBM), as a predictive factor for development of malignant glaucoma (MG). Design: Retrospective study in a tertiary care hospital. Participants: Cohort of 31 consecutive patients diagnosed with postsurgical MG...Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature
Clinical & Experimental Ophthalmology
Dec 2012
Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature
Background: Invasive fungal sinusitis is a rare condition that usually occurs in immuno-compromised patients and often presents as an orbital apex syndrome. It is frequently misdiagnosed on presentation and is almost always lethal without early treatment. Design: Retrospective case series of 14 consecutive patients..Systemic contact dermatitis to corticosteroids
Allergy
Oct 2012
Systemic contact dermatitis to corticosteroids
Background: Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic..Why do shape aftereffects increase with eccentricity?
Journal of Vision
Dec 2011
Why do shape aftereffects increase with eccentricity?
Studies have shown that spatial aftereffects increase with eccentricity. Here, we demonstrate that the shape-frequency and shape-amplitude aftereffects, which describe the perceived shifts in the shape of a sinusoidal-shaped contour following adaptation to a slightly different sinusoidal-shaped contour, also increase..Costimulatory molecule expression on human uveal melanoma cells: functional analysis of CD40 and B7-H1
Experimental Eye Research
Dec 2011
Costimulatory molecule expression on human uveal melanoma cells: functional analysis of CD40 and B7-H1
Costimulatory molecules play important roles in regulating T cell function in tumor immunity. In this study, we investigated costimulatory molecule expression on human uveal melanoma cells (a primary culture, and OCM-1, OMM-1 and 92-1 cell lines) and assessed the functional roles of selected costimulatory molecules...The deletion of Math5 disrupts retinal blood vessel and glial development in mice
Experimental Eye Research
Dec 2011
The deletion of Math5 disrupts retinal blood vessel and glial development in mice
Retinal vascular development is a complex process that is not yet fully understood. The majority of research in this area has focused on astrocytes and the template they form in the inner retina, which precedes endothelial cells in the mouse retina. In humans and dogs, however, astrocyte migration follows behind..Reflux of Drug During Intra-vitreal Anti-VEGF Therapies
Seminars in Ophthalmology
Nov 2011
Reflux of Drug During Intra-vitreal Anti-VEGF Therapies
Purpose: To report reflux of anti-VEGF drug during intravitreal injections. Method: Review of electronic case notes of patients undergoing intra-vitreal anti-VEGF treatments. Prospective data collection was performed with a specific emphasis on presence or absence of reflux. Results: 152 records of 102 eyes were..Review of Ranibizumab Trials for Neovascular Age-Related Macular Degeneration
Seminars in Ophthalmology
Nov 2011
Review of Ranibizumab Trials for Neovascular Age-Related Macular Degeneration
Ranibizumab, a recombinant, humanized, monoclonal antibody antigen-binding fragment that neutralizes all VEGF-A isoforms, is the first US FDA-approved therapy for neovascular age-related macular degeneration (AMD) to result in improvement in visual acuity. The benefit of intravitreal ranibizumab applies to all..Retinal oxygen saturation is altered in diabetic retinopathy
The British Journal of Ophthalmology
Nov 2011
Retinal oxygen saturation is altered in diabetic retinopathy
Aim Retinal oxygen metabolism is thought to be affected in diabetic retinopathy. The aim of this study was to test whether retinal vessel oxygen saturation is different in patients with diabetic retinopathy from that in healthy controls. Methods The retinal oximeter is based on a fundus camera. It estimates retinal..Retinal detachment repair by vitrectomy: simplified formulae to estimate the risk of failure
The British Journal of Ophthalmology
Feb 2011
Retinal detachment repair by vitrectomy: simplified formulae to estimate the risk of failure
Aim: Devise simplified formulae, using preoperative clinical data, to give risk estimates of (1) failure and (2) proliferative vitreoretinpathy (PVR) following primary retinal detachment repair by vitrectomy. Methods: 641 patients were analysed as part of an RCT investigating use of 5-fluorouracil and..Early diabetic changes in the nerve fibre layer at the macula detected by spectral domain optical coherence tomography
The British Journal of Ophthalmology
Jan 2011
Early diabetic changes in the nerve fibre layer at the macula detected by spectral domain optical coherence tomography
Aim: To detect early nerve fibre layer (NFL) changes around the optic disc and macula in diabetic patients using Cirrus HD-optical coherence tomography (OCT). Methods: Forty normal patients without any optic nerve or retinal disease, 37 patients with diabetes with no diabetic retinopathy (NDR) and 89 patients with..Effect of orbital bony decompression for Graves' orbitopathy on the volume of extraocular muscles
The British Journal of Ophthalmology
Jan 2011
Effect of orbital bony decompression for Graves' orbitopathy on the volume of extraocular muscles
Aim: To evaluate the change in the rectus muscle volume following orbital bony wall decompression for Graves' orbitopathy. Methods: We used a computer program (syngo Volume Evaluation) to measure the rectus muscles from the digital preoperative and postoperative orbital CT. Results: Of the 25 patients (20 women and..
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