Dermatology Medical Journal Abstracts
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Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: Results from a nationwide survey
Journal of the American Academy of Dermatology
Nov 2012
Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: Results from a nationwide survey
Background: Detailed nationwide surveys of the epidemiologic and clinical characteristics of bullous congenital ichthyosiform erythroderma (BCIE) (novel synonym: keratinolytic ichthyosis) in a large population have not been performed previously to our knowledge. Objective: We sought to estimate the number of patients..Unknown primary Merkel cell carcinoma: 23 new cases and a review
Journal of the American Academy of Dermatology
Nov 2012
Unknown primary Merkel cell carcinoma: 23 new cases and a review
Background: Knowledge is limited regarding unknown primary Merkel cell carcinoma (UPMCC). Objective: We sought to document the characteristics and behavior of UPMCC, and determine the most appropriate treatment. Methods: A multicenter, retrospective, consecutive study reviewing patients given a diagnosis of UPMCC..Skin cancer surveillance behaviors among US Hispanic adults
Journal of the American Academy of Dermatology
Nov 2012
Skin cancer surveillance behaviors among US Hispanic adults
Background: Little skin cancer prevention research has focused on the US Hispanic population. Objective: This study examined the prevalence and correlates of skin cancer surveillance behaviors among Hispanic adults. Methods: A population-based sample of 788 Hispanic adults residing in 5 southern and western states..Pregnancy and dermatologic therapy
Journal of the American Academy of Dermatology
Nov 2012
Pregnancy and dermatologic therapy
Dermatologists should be familiar with medication safety in pregnancy to be able to prescribe safely and confidently to pregnant women or women who may become pregnant during the course of treatment for dermatologic conditions. Topical medications should be considered first-line therapy for pregnant women, but certain..Large congenital melanocytic nevi: Therapeutic management and melanoma risk: A systematic review
Journal of the American Academy of Dermatology
Nov 2012
Large congenital melanocytic nevi: Therapeutic management and melanoma risk: A systematic review
Background: Large congenital melanocytic nevi (LCMN) are defined as congenital melanocytic nevi having a projected adult size exceeding 20 cm in diameter. They occur in 1 in 20,000 to 1 in 500,000 newborns. Therapeutic management of LCMN remains controversial and is often decided according to melanoma risk. Objective:..Spring and summer eruption of the elbows: A peculiar localized variant of polymorphous light eruption
Journal of the American Academy of Dermatology
Nov 2012
Spring and summer eruption of the elbows: A peculiar localized variant of polymorphous light eruption
Background: Polymorphous light eruption (PLE) is the most common form of idiopathic photodermatosis. Several morphologic variants of PLE have been described, including a localized form of PLE primarily affecting the helices of the ears. To our knowledge, the presence of lesions on the elbows as the unique manifestation..Analysis of sentinel lymph node positivity in patients with thin primary melanoma
Journal of the American Academy of Dermatology
Nov 2012
Analysis of sentinel lymph node positivity in patients with thin primary melanoma
Background: A minority of patients with T1 melanoma will have a positive sentinel lymph node (SLN) biopsy (SLNB) finding. Identifying who will develop metastatic disease is important in determining prognosis and treatment. Objective: We sought to identify clinical and histologic features predictive of a positive SLNB..Factors associated with female pattern hair loss and its prevalence in Taiwanese women: A community-based survey
Journal of the American Academy of Dermatology
Nov 2012
Factors associated with female pattern hair loss and its prevalence in Taiwanese women: A community-based survey
Background: Although female pattern hair loss (FPHL) has been considered simply the female counterpart of male pattern hair loss in men, the risk factors may differ. Objective: We sought to evaluate factors associated with FPHL and to estimate its prevalence in women. Method: In total, 26,226 subjects aged 30 years and..Nodular melanoma: A distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia
Journal of the American Academy of Dermatology
Nov 2012
Nodular melanoma: A distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia
Background: There is a growing body of evidence that nodular melanoma (NM), because of its association with increased growth rate and thickness at diagnosis, accounts for a substantial proportion of melanoma deaths. Objective: We sought to assess the contribution of NM to melanoma deaths in comparison with other tumor..Management of nonsexually acquired genital ulceration using oral and topical corticosteroids followed by doxycycline prophylaxis
Journal of the American Academy of Dermatology
Nov 2012
Management of nonsexually acquired genital ulceration using oral and topical corticosteroids followed by doxycycline prophylaxis
Background: Data regarding the treatment of nonsexually acquired genital ulceration (NSAGU) are limited. Objective: We sought to provide evidence for the safety and efficacy of topical and systemic corticosteroids followed by doxycycline prophylaxis for acute and recurrent NSAGU. Methods: A retrospective chart review..Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution
Journal of the American Academy of Dermatology
Nov 2012
Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution
Background: Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe systemic hypersensitivity reaction caused by specific drugs, in which herpesvirus reactivations and organ dysfunction occur during the course of the disease. Although recent reports have..c-Jun N-terminal kinase (JNK)-phospho-c-JUN (ser63/73) pathway is essential for FOXP3 nuclear translocation in psoriasis
Journal of Dermatological Science
Nov 2012
c-Jun N-terminal kinase (JNK)-phospho-c-JUN (ser63/73) pathway is essential for FOXP3 nuclear translocation in psoriasis
Background: In some psoriatic patients, impaired function of FOXP3+ regulatory T cells has been identified without well-uncovered mechanism(s). Meanwhile, dysregulation of FOXP3 nuclear translocation has been observed in some autoimmune syndromes and in some cancer cells. Objective: To investigate whether there is..Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update
Journal of Dermatological Science
Nov 2012
Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update
Human hair disorders comprise a number of different types of alopecia, atrichia, hypotrichosis, distinct hair shaft disorders as well as hirsutism and hypertrichosis. Their causes vary from genodermatoses (e.g. hypotrichoses) via immunological disorders (e.g. alopecia areata, autoimmune cicatrical alopecias) to..Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts
Journal of Dermatological Science
Nov 2012
Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts
Background: Systemic sclerosis (SSc) is a systemic inflammatory and fibrotic disease characterized by activation of circulating T lymphocytes. Objective: To determine phenotypic abnormalities of γ/δ T cells and whether γ/δ T cells influence fibroblasts activation in SSc patients. Methods: Number and proportion of..In vivo and in vitro evaluation of the use of a newly developed melatonin loaded emulsion combined with UV filters as a protective agent against skin irradiation
Journal of Dermatological Science
Nov 2012
In vivo and in vitro evaluation of the use of a newly developed melatonin loaded emulsion combined with UV filters as a protective agent against skin irradiation
Background: Melatonin has attracted attention because of their high antioxidant and anticarcinogenic activity. Otherwise, the use of sunscreens is recommended for patients after chemotherapy and radiotherapy treatments or to prevent UV radiation-induced skin damages that may result in pre-cancerous and cancerous skin..Association of melanogenesis genes with skin color variation among Japanese females
Journal of Dermatological Science
Nov 2012
Association of melanogenesis genes with skin color variation among Japanese females
Background: Skin color mainly reflects pigmentation resulting from melanin. Although many of the detailed molecular mechanisms involved in melanin pigmentation are being revealed, little is understood about the genetic components responsible for variations in skin color within or between human populations. Objective:..MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells
Journal of Dermatological Science
Nov 2012
MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells
Background: MiRNAs remain at a constant level under physiological conditions. However, how the expression of miRNAs is regulated and what are the roles of miRNAs in response to UVB damage to skin cells is still not fully understood. In our preliminary study, we observed that miR-23a was upregulated following a..Associations between aberrant DNA methylation and transcript levels of DNMT1 and MBD2 in CD4+T cells from patients with systemic lupus erythematosus
Australasian Journal of Dermatology
Nov 2012
Associations between aberrant DNA methylation and transcript levels of DNMT1 and MBD2 in CD4+T cells from patients with systemic lupus erythematosus
Background/Objectives: It seems that global DNA hypomethylation in CD4+T cells is linked to the pathogenesis of systemic lupus erythematosus (SLE). However, the underlying mechanism by which SLE patients show hypomethylated DNA remains unclear. This study explored the relationship between DNA methylation patterns and..The protective effects of 6-CySeCD with GPx activity against UVB-induced injury in HaCaT cells
Australasian Journal of Dermatology
Oct 2012
The protective effects of 6-CySeCD with GPx activity against UVB-induced injury in HaCaT cells
Background: The generation of harmful reactive oxygen species (ROS) induced by UVB irradiation could induce cell apoptosis and change the cell cycle. 6A,6A′-dicyclohexylamine-6B,6B′-diselenide-bis-β-cyclodextrin (6-CySeCD) is a novel glutathione peroxidase (GPx; EC 1.11.1.9) mimic. The aim of this study was to..Cross-evaluation of facial hyperpigmented lesions based on fluorescence color image and cross-polarized color image
Skin Research and Technology
Oct 2012
Cross-evaluation of facial hyperpigmented lesions based on fluorescence color image and cross-polarized color image
Background/purpose: Hyperpigmentation is a common skin problem that looks darker than normal skin regions. Accurate evaluation of a hyperpigmented lesion (HPL) is of clinical importance because proper choice of treatment can be dependent on it. This study aimed to differentiate between epidermal and dermal HPLs...Venous malformations: Clinical course and management of vascular birthmark clinic cases
Australasian Journal of Dermatology
Oct 2012
Venous malformations: Clinical course and management of vascular birthmark clinic cases
Background/Objectives: Venous malformations (VM) are an uncommon vascular malformation with an estimated incidence of 1–2 per 10 000 births. The aim was to define the clinical characteristics and management of children with VM and develop a database for future research. Methods: A retrospective chart review of all..Frequency of positive patch test reactions to preservatives: The Australian experience
Australasian Journal of Dermatology
Oct 2012
Frequency of positive patch test reactions to preservatives: The Australian experience
Background/Objectives: Preservatives are important causes of allergic contact dermatitis. The frequency of allergy to preservatives in Australia has been unknown to date. Our objectives are to report the frequency of positive preservative patch test reactions in Australia, comparing them to the published international..Office based dermatological surgery and Mohs surgery: A prospective audit of surgical procedures and complications in a procedural dermatology practice
Australasian Journal of Dermatology
Oct 2012
Office based dermatological surgery and Mohs surgery: A prospective audit of surgical procedures and complications in a procedural dermatology practice
Background/Objectives: Dermatologists commonly perform surgical procedures, including Mohs micrographic surgery, in an outpatient, office-based setting. Although this may be widely perceived to be safe and effective, formal data on the practice are limited. The aim of this study was to examine the range of surgical..Exploratory study of the typology of various grades of mature skin
Skin Research and Technology
Oct 2012
Exploratory study of the typology of various grades of mature skin
Background: Post-menopausal skin aging has intrinsic as well as extrinsic origins, and this process induces important disparities of appearance and feeling within an age range. Objective: The objective of this study was to identify 3 grades of maturity of the facial skin of menopausal women. Material and Method: One..Biophysical measures of skin tissue water: variations within and among anatomical sites and correlations between measures
Skin Research and Technology
Oct 2012
Biophysical measures of skin tissue water: variations within and among anatomical sites and correlations between measures
Background: Biophysical measures to assess that skin water includes stratum corneum hydration via capacitance (SC), dermal water via tissue dielectric constant (TDC), and transepidermal water loss (TEWL). Since skin differs among anatomical sites and tissue depth we sought to determine the site and depth variability of..Chronic vulvovaginal candidiasis: What we know and what we have yet to learn
Australasian Journal of Dermatology
Sep 2012
Chronic vulvovaginal candidiasis: What we know and what we have yet to learn
Vulvovaginal candidiasis (VVC) is defined as vulvovaginitis, causally associated with Candida species in the vagina. It is seen commonly in vulval clinics as a cause of persistent vulvovaginitis and yet this chronic condition is yet to be formally defined and explained. The classic symptom complex of chronic itch, pain..Development of new in vivo imaging methodology and system for the rapid and quantitative evaluation of the visual appearance of facial skin firmness
Skin Research and Technology
Sep 2012
Development of new in vivo imaging methodology and system for the rapid and quantitative evaluation of the visual appearance of facial skin firmness
Background/aims: Lack of firmness is a key sign of skin aging, but there are no methods for quantifying the firmness of facial skin as perceived visually. The objective of this study was to develop a convenient and accurate method for this purpose. Methods: A compact imaging system (Magic Ring®) was developed to..The basic chromospheres of skin that might not be differentiated visually: observations on aneurysmal fibrous histiocytomas and malignant melanomas
Skin Research and Technology
Sep 2012
The basic chromospheres of skin that might not be differentiated visually: observations on aneurysmal fibrous histiocytomas and malignant melanomas
Aim: Aneurysmal fibrous histiocytoma (AFH) is a variant of fibrous histiocytoma, which has a cleft-like cavernous blood-filled space in the tumor. It appears as a single reddish black tumor with variable levels of pain and size from its bleeding. And, it must be differentiated from other similar looking malignant..High-resolution imaging of basal cell carcinoma: a comparison between multiphoton microscopy with fluorescence lifetime imaging and reflectance confocal microscopy
Skin Research and Technology
Sep 2012
High-resolution imaging of basal cell carcinoma: a comparison between multiphoton microscopy with fluorescence lifetime imaging and reflectance confocal microscopy
Aims: The aim of this study was to compare morphological aspects of basal cell carcinoma (BCC) as assessed by two different imaging methods: in vivo reflectance confocal microscopy (RCM) and multiphoton tomography with fluorescence lifetime imaging implementation (MPT-FLIM). Methods: The study comprised 16 BCCs for..Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy
Skin Research and Technology
Sep 2012
Non-invasive identification of melanoma with near-infrared and skin impedance spectroscopy
Background/purpose: An early diagnosis of cutaneous malignant melanoma is of high importance for good prognosis. An objective, non-invasive instrument could improve the diagnostic accuracy of melanoma and decrease unnecessary biopsies. The aim of this study was to investigate the use of Near-infrared and skin impedance..Analysis of the temporal change in biophysical parameters after fractional laser treatments using reflectance confocal microscopy
Skin Research and Technology
Sep 2012
Analysis of the temporal change in biophysical parameters after fractional laser treatments using reflectance confocal microscopy
Background: Fractional photothermolysis is a popular treatment option for photorejuvenation. Previous literature studies have demonstrated the clinical effectiveness of fractional photothermolysis on cutaneous photoaging; however, the associated changes in biophysical properties of the skin following fractional..Influence of Stratum Corneum on the entire skin mechanical properties, as predicted by a computational skin model
Skin Research and Technology
Aug 2012
Influence of Stratum Corneum on the entire skin mechanical properties, as predicted by a computational skin model
Background/Purpose: Skin mechanical properties are globally well described. The aim of this paper is to evaluate, by means of a numerical model, the influence of Stratum Corneum (SC) on skin folding resulting from an in-plane compression. Methods: A computational skin model was developed where skin is divided into..Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation
Experimental Dermatology
Aug 2012
Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation
Cannabinoid receptors (CBR) 1 and 2 have been implicated in keratinocyte differentiation/proliferation. How CB receptors affect epidermal permeability barrier and stratum corneum structure and function remains unclear. Permeability barrier abrogation was induced by sequential tape-stripping of the SC and assessed in..Restricting dietary magnesium accelerates ectopic connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6-/-)
Experimental Dermatology
Aug 2012
Restricting dietary magnesium accelerates ectopic connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6-/-)
Ectopic mineralization, linked to a number of diseases, is a major cause of morbidity and mortality in humans. Pseudoxanthoma elasticum (PXE) is a heritable multisystem disorder characterized by calcium phosphate deposition in various tissues. The mineral content of diet has been suggested to modify the disease..Development and evaluation of an automatic acne lesion detection program using digital image processing
Skin Research and Technology
Aug 2012
Development and evaluation of an automatic acne lesion detection program using digital image processing
Background/purpose: Existing acne grading methods, which depend on overall impression, require a long training period and there is a high degree of variability among raters, including trained dermatologists. The use of lesion count provides fair reproducibility but the method is time consuming. New technologies in..Effect of Exercise-induced Sweating on facial sebum, stratum corneum hydration, and skin surface pH in normal population
Skin Research and Technology
Aug 2012
Effect of Exercise-induced Sweating on facial sebum, stratum corneum hydration, and skin surface pH in normal population
Background: Evidence demonstrated that sweat was an important factor affecting skin physiological properties. Aims: We intended to assess the effects of exercise-induced sweating on the sebum, stratum corneum (SC) hydration and skin surface pH of facial skin. Materials & Methods: 102 subjects (aged 5–60, divided into..The formation of friction blisters on the foot: the development of a laboratory-based blister creation model
Skin Research and Technology
Aug 2012
The formation of friction blisters on the foot: the development of a laboratory-based blister creation model
Background/Purpose: Friction blisters on the foot are a debilitating pathology that have an impact on activities of daily living and can severely impair function. The purpose of this study was to test the hypotheses that digital infrared thermographic imaging will reveal: 1) a correlation between load application to..In vivo measurement of breast skin elasticity and breast skin thickness
Skin Research and Technology
Aug 2012
In vivo measurement of breast skin elasticity and breast skin thickness
Background: The mechanical properties of the breast skin play an important role in explaining the changes associated with radiotherapy, tissue expansion, and breast reconstruction surgery. Quantitative measurement of mechanical properties of breast skin is essential for surgical preplanning and outcome prediction. We..In vitro prediction of in vivo skin damage associated with the wiping of dry tissue against skin
Skin Research and Technology
Aug 2012
In vitro prediction of in vivo skin damage associated with the wiping of dry tissue against skin
Background: The ideal gentle cleansing product is one that effectively removes soils while minimizing damage to the skin. Thus, measuring physical abrasion caused by cleansing tissues is critical to the continued development of gentle cleansing products. Current analysis of cleansing materials for skin gentleness is..A perceptually oriented method for contrast enhancement and segmentation of dermoscopy images
Skin Research and Technology
Aug 2012
A perceptually oriented method for contrast enhancement and segmentation of dermoscopy images
Background/Purpose: Dermoscopy images often suffer from low contrast caused by different light conditions, which reduces the accuracy of lesion border detection. Accordingly for lesion recognition, automatic melanoma border detection (MBD) is an initial as well as crucial task. Method: In this article, a novel..“Assessment of chronic sclerodermoid Graft-versus-Host Disease patients, using 20MHz high-frequency ultrasonography and cutometer methods”
Skin Research and Technology
Aug 2012
“Assessment of chronic sclerodermoid Graft-versus-Host Disease patients, using 20MHz high-frequency ultrasonography and cutometer methods”
The development of an adverse graft-versus-host disease (GvHD) is a major complication of stem cell transplantations, which are widely used to cure increasing number of hematologic malignancies. Patients with chronic GvHD are at risk of joint contractures secondary to sclerodermatous skin changes. Several clinical..Wild Plum: novel blue fluorescent compounds capable of luminosity restoration in sun-exposed skin
Skin Research and Technology
Aug 2012
Wild Plum: novel blue fluorescent compounds capable of luminosity restoration in sun-exposed skin
Background: Novel, blue fluorescent solids referred to as Wild Plum compounds can camouflage skin imperfections when incorporated into cosmetic products. We evaluated the relationship between sun exposure and skin fluorescence and determined if the application of Wild Plum formulations could restore lost fluorescence..Diagnosis of BCC by multiphoton laser tomography
Skin Research and Technology
Jul 2012
Diagnosis of BCC by multiphoton laser tomography
Background/purpose: Multiphoton Laser Tomography (MPT) is a non-linear optical technique that gives access to morphology and structure of both cells and extracellular matrix of the skin through the combination of autofluorescence imaging and second harmonic generation (SHG). The aim of this study was to identify MPT..Safety and efficacy of a non–pesticide-based head lice treatment: Results of a randomised comparative trial in children
Australasian Journal of Dermatology
Jul 2012
Safety and efficacy of a non–pesticide-based head lice treatment: Results of a randomised comparative trial in children
Background/Objectives: Increasing resistance to pesticide-based head lice treatments has resulted in the need for alternative products to treat head lice infestations, but there are few clinical studies that have adequately tested these products. This multicentre, randomised, assessor-blind, parallel-group phase IV..Hypertrophy in port-wine stains: Prevalence and patient characteristics in a large patient cohort
Journal of the American Academy of Dermatology
Jul 2012
Hypertrophy in port-wine stains: Prevalence and patient characteristics in a large patient cohort
Background: Port-wine stains (PWS) may thicken and darken with age. Little is known about the pathogenesis and epidemiology of PWS hypertrophy because of the lack of large studies. Objective: We sought to assess the prevalence and characteristics of patients with hypertrophic PWS. Methods: Medical records and clinical..Influence of surface charge of gold nanorods on skin penetration
Skin Research and Technology
Jul 2012
Influence of surface charge of gold nanorods on skin penetration
Background/purpose: The skin plays an important role as a protective barrier against toxic environments and also is a route of drug administration. In spite of evidence for and interest in the skin penetration of nanoparticles, no study has examined the effect of nanoparticle surface charge on percutaneous absorption...Connective tissue nevi in children: Institutional experience and review
Journal of the American Academy of Dermatology
Jun 2012
Connective tissue nevi in children: Institutional experience and review
Background: Connective tissue nevi (CTN) are circumscribed hamartomas of the skin in which there is an abnormal mixture of normal components of the dermis that may be sporadic or associated with syndromes such as Buschke-Ollendorff, tuberous sclerosis, and Proteus. Objective: We sought to specify the clinical and..Efficacy of mycophenolate mofetil in severe mucocutaneous lichen planus: a retrospective review of 10 patients
British Journal of Dermatology
Jun 2012
Efficacy of mycophenolate mofetil in severe mucocutaneous lichen planus: a retrospective review of 10 patients
Background: Ulcerative lichen planus is an uncommon and severe subtype of lichen planus primarily affecting the oral mucosal surfaces. It may be associated with significant morbidity and often requires immunosuppressive therapy to achieve disease control. There have been no previous reports in which objective outcome..Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24
British Journal of Dermatology
Jun 2012
Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24
Background: Psoriasis is a Th17/Th1-mediated skin disease that often responds to antitumour necrosis factor (TNF)-α therapies, such as etanercept. Objectives: To better define mechanisms by which etanercept improves psoriasis and to gain insight into disease pathogenesis. Methods: We investigated the early biochemical..The relevance of patch testing in peristomal dermatitis
British Journal of Dermatology
Jun 2012
The relevance of patch testing in peristomal dermatitis
Background: Skin disorders are a common problem for ostomates, resulting in more than a third of visits to a stoma nurse. Irritant reactions, particularly irritant contact dermatitis, are the most frequently seen, accounting for > 50% of problems in some studies. Objectives: To report our experience in patch testing..Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration
British Journal of Dermatology
Jun 2012
Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration
Background: A short course of narrowband ultraviolet B (NB-UVB) exposures increases the serum 25-hydroxyvitamin D [25(OH)D] concentration in patients with psoriasis and healthy subjects. Objectives: To compare the effects of NB-UVB and oral vitamin D substitution in healthy subjects in winter. Methods: Healthy adult..Methotrexate polyglutamates as a marker of patient compliance and clinical response in psoriasis: a single-centre prospective study
British Journal of Dermatology
Jun 2012
Methotrexate polyglutamates as a marker of patient compliance and clinical response in psoriasis: a single-centre prospective study
Background: Methotrexate is activated by the sequential addition of glutamic acid residues to form methotrexate polyglutamates (MTXPG1–5). MTXPG1–5 inhibit enzymes of the folate–purine–pyrimidine pathways, and longer-chain MTXPG3–5 species are more active. Objectives: To determine the pattern of erythrocyte MTXPG1–5 in..Intralesional rituximab in the treatment of indolent primary cutaneous B-cell lymphomas: an epidemiological observational multicentre study. The Spanish Working Group on Cutaneous Lymphoma
British Journal of Dermatology
Jun 2012
Intralesional rituximab in the treatment of indolent primary cutaneous B-cell lymphomas: an epidemiological observational multicentre study. The Spanish Working Group on Cutaneous Lymphoma
Background: Intravenous rituximab is a safe and effective option for the treatment of systemic non-Hodgkin B-cell lymphoma. The effectiveness of intralesional rituximab (ILR) in primary cutaneous B-cell lymphomas (PCBL) has been described in a small number of patients. Objectives: To evaluate the effectiveness,..Psoriasis, hepatitis B, and the tumor necrosis factor-alpha inhibitory agents: A review and recommendations for management
Journal of the American Academy of Dermatology
Jun 2012
Psoriasis, hepatitis B, and the tumor necrosis factor-alpha inhibitory agents: A review and recommendations for management
Background: Tumor necrosis factor inhibitory agents are currently considered to be contraindicated in psoriatic patients with hepatitis B. Objective: We aim to provide guidance to dermatologists on the use of tumor necrosis factor inhibitor therapy in these patients. Methods: The current literature was reviewed..Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice
Journal of Dermatological Science
Jun 2012
Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice
Background: Melaleuca alternifolia (tea tree) oil (TTO) applied topically in a dilute (10%) dimethyl sulphoxide (DMSO) formulation exerts a rapid anti-cancer effect after a short treatment protocol. Tumour clearance is associated with skin irritation mediated by neutrophils which quickly and completely resolves upon..Glutamine suppresses dinitrophenol fluorobenzene-induced allergic contact dermatitis and itching: Inhibition of contact dermatitis by glutamine
Journal of Dermatological Science
Jun 2012
Glutamine suppresses dinitrophenol fluorobenzene-induced allergic contact dermatitis and itching: Inhibition of contact dermatitis by glutamine
Background: Cytoplasmic phospholipase A2 (cPLA2) is importantly implicated in a variety of inflammatory diseases by liberating arachidonic acid from phospholipids. The increased cPLA2 activities as well as increased levels of cPLA2 metabolites are associated with pathogenesis of many inflammatory skin disorders..N-acetyl-S-farnesyl-L-cysteine Suppresses Chemokine Production by Human Dermal Microvascular Endothelial Cells
Experimental Dermatology
Jun 2012
N-acetyl-S-farnesyl-L-cysteine Suppresses Chemokine Production by Human Dermal Microvascular Endothelial Cells
Isoprenylcysteine (IPC) molecules modulate G-protein-coupled receptor signalling. The archetype of this class is N-acetyl-S-farnesyl-l-cysteine (AFC). Topical application of AFC locally inhibits skin inflammation and elicitation of contact hypersensitivity in vivo. However, the mechanism of these anti-inflammatory..Analysis of aging effects on chemical property of human hair by Fourier transform infrared spectroscopy
Skin Research and Technology
Jun 2012
Analysis of aging effects on chemical property of human hair by Fourier transform infrared spectroscopy
Background: In the previous work, we investigated the aging effect on morphology and mechanical property of the hair by using atomic force microscopy. Objectives: The effects of aging on chemical properties of human hair were investigated by Fourier transform infrared (FT-IR) spectroscopy. Methods: Healthy hair samples..Pre-operative assessment of basal cell carcinoma dimensions using high frequency ultrasonography and its correlation with histopathology
Skin Research and Technology
Jun 2012
Pre-operative assessment of basal cell carcinoma dimensions using high frequency ultrasonography and its correlation with histopathology
Introduction: High frequency ultrasonography (HFUS) is a non-invasive, low risk method which can provide real-time visual information regarding different processes in cutaneous tissue. The goal of this study is to compare the accuracy of HFUS in determining depth and width of basal cell carcinoma (BCC) lesions compared..Discriminative power of visual attributes in dermatology
Skin Research and Technology
Jun 2012
Discriminative power of visual attributes in dermatology
Background/Purpose: Visual characteristics such as color and shape of skin lesions play an important role in the diagnostic process. In this contribution, we quantify the discriminative power of such attributes using an information theoretical approach. Methods: We estimate the probability of occurrence of each..Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear
Journal of Dermatological Science
Jun 2012
Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear
Background: Irritant contact dermatitis (ICD) is an inflammatory skin disease triggered by exposure to a chemical that is toxic or irritating to the skin. A major characteristic of chronic ICD is an inflammatory dry-skin condition with associated itching. Although glucosylceramide (GlcCer) is known to improve the skin..Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells
Journal of Dermatological Science
Jun 2012
Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells
Background: With the introduction of hair regeneration techniques using epidermal and dermal cells, hair follicle regeneration became much easier and faster. Current success has been dependent on the availability of cells from newborn or embryonic mice. We recently observed that the hair-inducing ability of newborn..Knockdown of paraoxonase 1 expression influences the ageing of human dermal microvascular endothelial cells
Experimental Dermatology
Jun 2012
Knockdown of paraoxonase 1 expression influences the ageing of human dermal microvascular endothelial cells
Skin is one of the most commonly studied tissues for microcirculation research owing to its close correlation of cutaneous vascular function, ageing and age-related cardiovascular events. To elucidate proteins that determine this correlation between endothelial cell function and ageing in the vascular environment of..Multiphoton laser tomography and fluorescence lifetime imaging of basal cell carcinoma: Morphologic Features for Non-Invasive Diagnostics
Experimental Dermatology
Jun 2012
Multiphoton laser tomography and fluorescence lifetime imaging of basal cell carcinoma: Morphologic Features for Non-Invasive Diagnostics
Multiphoton laser tomography (MPT) combined with fluorescence lifetime imaging (FLIM) is a non-invasive imaging technique, which gives access to the cellular and extracellular morphology of the skin. The aim of our study was to assess the sensitivity and specificity of MPT/FLIM descriptors for basal cell carcinoma..Protoporphyrin IX formation and photobleaching in different layers of normal human skin: Methyl- and hexylaminolevulinate and different light sources
Experimental Dermatology
Jun 2012
Protoporphyrin IX formation and photobleaching in different layers of normal human skin: Methyl- and hexylaminolevulinate and different light sources
Topical photodynamic therapy (PDT) is used for various skin disorders, and selective targeting of specific skin structures is desirable. The objective was to assess accumulation of PpIX fluorescence and photobleaching within skin layers using different photosensitizers and light sources. Normal human skin was..In vivo near-infrared autofluorescence imaging of pigmented skin lesions: methods, technical improvements and preliminary clinical results
Skin Research and Technology
Jun 2012
In vivo near-infrared autofluorescence imaging of pigmented skin lesions: methods, technical improvements and preliminary clinical results
Background/purposes: Fluorescence emission from in vivo cutaneous melanin was recently detected under near-infrared (NIR) excitation by our group. We then built a prototype NIR autofluorescence imaging system to observe and characterize the melanin distribution in human skin. In this article, we reported a new setup of..Analysis of clinical and dermoscopic features for basal cell carcinoma neural network classification
Skin Research and Technology
Jun 2012
Analysis of clinical and dermoscopic features for basal cell carcinoma neural network classification
Background: Basal cell carcinoma (BCC) is the most commonly diagnosed cancer in the USA. In this research, we examine four different feature categories used for diagnostic decisions, including patient personal profile (patient age, gender, etc.), general exam (lesion size and location), common dermoscopic (blue-gray..Investigation of the relationship between wrinkle formation and deformation of the skin using three-dimensional motion analysis
Skin Research and Technology
Jun 2012
Investigation of the relationship between wrinkle formation and deformation of the skin using three-dimensional motion analysis
Background: Although there have been many studies investigating facial movements using three-dimensional (3D) quantitative analysis, the possible relationship between the levels of wrinkles and the movement distance of facial skin has previously not been reported. Method: Forty-four healthy Japanese women (from 20 to..Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis
Journal of Dermatological Science
Jun 2012
Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis
Background: The pathophysiological mechanisms underlying chronic pruritic skin diseases, e.g. atopic dermatitis (AD), and effective therapies remain elusive due to the paucity of animal models. Recently, we rediscovered that injection of capsaicin into rat pups resulted in vigorous scratching behavior and chronically..Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes
Journal of Dermatological Science
Jun 2012
Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes
Background: Topical indigo naturalis ointment is clinically proved to be an effective therapy for plaque-type psoriasis. Indirubin, as the active component of indigo naturalis, inhibits cell proliferation of epidermal keratinocytes. However, the detailed underlying mechanism is not fully understood. Objective: To..Psoriasis: rationale for targeting IL-17
British Journal of Dermatology
Jun 2012
Psoriasis: rationale for targeting IL-17
The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin. The cytokine interleukin (IL)-17A plays a key role in host defence against extracellular bacteria and..Greying of the human hair. A worldwide survey, re-visiting the “50” rule of thumb.
British Journal of Dermatology
Jun 2012
Greying of the human hair. A worldwide survey, re-visiting the “50” rule of thumb.
Background: While numerous papers have reported on the biological mechanisms of human hair pigmentation and greying, epidemiological descriptions of both natural hair colour and the greying process, worldwide, remain scarce. Objectives: To assess hair colour and greying in a large world sample of human subjects, and to..Study of oral, ear, nose and throat involvement in pemphigus vulgaris by endoscopic examination
British Journal of Dermatology
Jun 2012
Study of oral, ear, nose and throat involvement in pemphigus vulgaris by endoscopic examination
Background: Pemphigus vulgaris (PV) is an autoimmune blistering skin disorder characterized by the presence of suprabasal acantholysis and autoantibodies against desmoglein 3. There are two different clinical forms: mucocutaneous (MCPV) and mucosal (MPV). However, little is known about PV lesions in oral, ear, nose and..Influence of the timing of ultrasound application on the penetration of corticosteroids
Skin Research and Technology
Jun 2012
Influence of the timing of ultrasound application on the penetration of corticosteroids
Background: The application of ultrasound to enhance the transdermal transport of drugs is often referred to as ‘sonophoresis’. In physiotherapy sonophoresis is applied to the skin through two different procedures: (1) the pre-treatment procedure where the skin is treated with ultrasound irradiation prior to the drug..Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations
Skin Research and Technology
Jun 2012
Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations
Objective: The goal of the described study was complex assessment of age-specific morphofunctional features of skin of different anatomic localization using optical coherence tomography (OCT). Methods: Forty-three healthy volunteers aging from 4 to 74 years were enrolled in the study. Optical and functional skin..Influence of gravity on the skin thermal behavior: experimental study using dynamic infrared thermography
Skin Research and Technology
Jun 2012
Influence of gravity on the skin thermal behavior: experimental study using dynamic infrared thermography
Background/Aim: To better understand the thermomechanical behavior of the skin and its direct environment, we present an experimental study using dynamic infrared thermography. This experimental study aims to highlight quantitatively some effects of blood flow on the heat diffusion. Methods: The originality of this..Quantification of skin lesions with a 3D stereovision camera system: validation and clinical applications
Skin Research and Technology
Jun 2012
Quantification of skin lesions with a 3D stereovision camera system: validation and clinical applications
Background/Purpose: Three-dimensional (3D) imaging of the skin is a challenging technique. A new 3D digital camera system has been developed that enables 3D reconstruction of the skin and subsequently allows volumetric quantification. Herein we present validation data on calibrated phantoms and the clinical application..Systemic sclerosis: an ultrasonographic study of skin and subcutaneous tissue in relation to clinical findings
Skin Research and Technology
Jun 2012
Systemic sclerosis: an ultrasonographic study of skin and subcutaneous tissue in relation to clinical findings
Background: Skin thickening and tightness are characteristic manifestations of systemic sclerosis (SSc) and the only major diagnostic criterion. The aim of this study is to compare the results of high frequency ultrasound of skin and subcutaneous tissue (SC) in SSc patients and healthy control subjects and also to..Treatment-Refractory Actinic Keratoses Successfully Treated Using Simultaneous Combination Topical 5-Fluorouracil Cream and Imiquimod Cream: A Case–Control Study
Dermatologic Surgery
Jun 2012
Treatment-Refractory Actinic Keratoses Successfully Treated Using Simultaneous Combination Topical 5-Fluorouracil Cream and Imiquimod Cream: A Case–Control Study
Background: Most actinic keratoses (AKs) respond to standard treatments, but a subset persist and require further intervention. We report a series of 10 patients with AKs that failed to respond to conventional treatment with cryotherapy and topical monotherapy but responded completely to simultaneous therapy with..Tretinoin Microsphere Gel 0.04% Pump for Treating Acne Vulgaris in Preadolescents: A Randomized, Controlled Study
Pediatric Dermatology
Jun 2012
Tretinoin Microsphere Gel 0.04% Pump for Treating Acne Vulgaris in Preadolescents: A Randomized, Controlled Study
Although acne vulgaris is common in preadolescents (<13 yrs), few acne treatments are currently approved for children. This study assessed the safety and efficacy of tretinoin microsphere gel (TMG) 0.04% pump in children aged 9–11 with acne vulgaris. In this multicenter, randomized, double-blind, vehicle-controlled..Repair of Full-Thickness Alar Defects
Dermatologic Surgery
Jun 2012
Repair of Full-Thickness Alar Defects
Background: A basal cell carcinoma can invade the cartilage in the nasal ala and can reach the nasal vestibule skin. A full-thickness reconstruction of the nasal ala is required to repair the tissue damage after tumor removal. We combined an auricular composite graft with a nasolabial flap to repair the defects in the..Direct primary closure without undermining in the repair of vermilionectomy defects of the lower lip
British Journal of Dermatology
Jun 2012
Direct primary closure without undermining in the repair of vermilionectomy defects of the lower lip
Background: Vermilionectomy is an excisional technique for the treatment of lower lip squamous cell carcinoma and actinic cheilitis. The vermilionectomy defect is usually repaired by a labial mucosal advancement flap. Traditionally, the mucosal wound margins are widely undermined but this can be associated with..An educational programme for patients with psoriasis and atopic dermatitis: a prospective randomized controlled trial
British Journal of Dermatology
Jun 2012
An educational programme for patients with psoriasis and atopic dermatitis: a prospective randomized controlled trial
Background: Patient education in addition to standard treatment, with the aim of affecting care through courses, is a relatively new concept in dermatology. Here we introduce a randomized controlled trial (RCT) regarding a previously described 12-week educational programme for chronic skin diseases. Objectives: The..A randomized, half-side comparative study of aminolevulinate photodynamic therapy versus CO2 laser ablation in immunocompetent patients with multiple actinic keratoses
British Journal of Dermatology
Jun 2012
A randomized, half-side comparative study of aminolevulinate photodynamic therapy versus CO2 laser ablation in immunocompetent patients with multiple actinic keratoses
Background: Photodynamic therapy (PDT) and laser ablation (LA) are frequently used treatment options for multiple actinic keratoses (AK), yet they have not been compared head to head. Objectives: To compare PDT and carbon dioxide (CO2) LA in the management of multiple AK using objective and subjective outcome measures...Genetic predictors of susceptibility to cutaneous fungal infections: A pilot genome wide association study to refine a candidate gene search
Journal of Dermatological Science
Jun 2012
Genetic predictors of susceptibility to cutaneous fungal infections: A pilot genome wide association study to refine a candidate gene search
Background: Trichophyton tonsurans is the foremost fungal pathogen of minority children in the U.S. Despite overwhelming infection rates, it does not appear that this fungus infects children in a non-specific manner. Objective: This study was designed to identify genes that may predispose or protect a child from T...Mucocutaneous complications of smoking cessation
Journal of the American Academy of Dermatology
Jun 2012
Mucocutaneous complications of smoking cessation
Despite widespread knowledge of the morbidity and mortality associated with smoking, this addictive practice continues to be quite prevalent throughout the United States, as about one-fifth of the population smokes cigarettes. Because of the financial burden, and the significant psychosocial and health implications of..A modified method using the SonoPrep® ultrasonic skin permeation system for sampling human interstitial fluid is compatible with proteomic techniques
Dermatologic Surgery
Jun 2012
A modified method using the SonoPrep® ultrasonic skin permeation system for sampling human interstitial fluid is compatible with proteomic techniques
Background: The use of biomarkers in skin is a novel diagnostic tool. Interstitial fluid (ISF) from skin provides a snapshot of proteins secreted at the time of sampling giving insights into the patient's health status. Methods: A minimally invasive technique for the transdermal collection of human ISF proteins. A low..Analysis of human skin tissue by millimeter-wave reflectometry
Dermatologic Surgery
Jun 2012
Analysis of human skin tissue by millimeter-wave reflectometry
Background/Purpose: Millimeter-wave reflectometry is a potentially interesting technique to analyze the human skin in vivo in order to determine the water content locally in the skin. Purpose of this work is to investigate the possibility of skin-tissue differentiation. In addition, it addresses the influence of the..Hyperspectroscopic screening of melanoma on acral volar skin
Dermatologic Surgery
Jun 2012
Hyperspectroscopic screening of melanoma on acral volar skin
Background/Purpose: Early detection and proper excision of the primary lesions of melanoma are crucial for reducing melanoma-related deaths. To support the early detection of melanoma, automated melanoma-screening systems have been extensively studied and developed. In this article, a previously reported hyperspectral..Epidemiology of Dermatofibrosarcoma Protuberans in Alberta, Canada, from 1988 to 2007
Dermatologic Surgery
Jun 2012
Epidemiology of Dermatofibrosarcoma Protuberans in Alberta, Canada, from 1988 to 2007
Background: There have only been a few population-based, epidemiologic studies assessing dermatofibrosarcoma protuberans (DFSP). Objective: To assess the epidemiology of DFSP in Alberta, Canada, over a 20-year period. Methods: A population-based, retrospective analysis of all cases of DFSP in Alberta was conducted..Diagnostic Utility of Cytokeratin 17 Immunostaining in Morpheaform Basal Cell Carcinoma and for Facilitating the Detection of Tumor Cells at the Surgical Margins
Dermatologic Surgery
Jun 2012
Diagnostic Utility of Cytokeratin 17 Immunostaining in Morpheaform Basal Cell Carcinoma and for Facilitating the Detection of Tumor Cells at the Surgical Margins
Background: The morpheaform subtype of basal cell carcinoma (BCC) often presents a diagnostic histological challenge, and its true margin may be difficult to determine with accuracy. This tumor may also be difficult to distinguish from other adnexal neoplasms having a benign clinical course. Previous work has shown..Food allergy testing in infantile eczema: A clinical approach and algorithm
Australasian Journal of Dermatology
Jun 2012
Food allergy testing in infantile eczema: A clinical approach and algorithm
The complex relationship between food allergy and infantile eczema has prompted divergent approaches to investigating potential food triggers in eczematous patients. It is well recognised that a significant proportion of infants with eczema have immunoglobulin E-mediated food allergy, reported to range between 20–80%...Successful treatment of moderate to severe plaque psoriasis with the PEGylated Fab′ certolizumab pegol: results of a phase II randomized, placebo-controlled trial with a re-treatment extension
British Journal of Dermatology
Jun 2012
Successful treatment of moderate to severe plaque psoriasis with the PEGylated Fab′ certolizumab pegol: results of a phase II randomized, placebo-controlled trial with a re-treatment extension
Background: Certolizumab pegol (CZP) is a PEGylated antitumour necrosis factor agent. Objectives: To evaluate the efficacy and safety of CZP in patients with plaque psoriasis. Methods: In a randomized, placebo-controlled, double-blind study, 176 patients with moderate to severe psoriasis received placebo or CZP 400 mg..Effect of biologic therapies targeting tumour necrosis factor-α on cutaneous mesenchymal stem cells in psoriasis
British Journal of Dermatology
Jun 2012
Effect of biologic therapies targeting tumour necrosis factor-α on cutaneous mesenchymal stem cells in psoriasis
Background: Psoriasis is a Th1 immune-mediated, inflammatory disease, in which skin lesions appear many years before the related metabolic and cardiovascular comorbidities, according to the theory of the ‘psoriatic march’. Inducible nitric oxide synthetase (iNOS), tumour necrosis factor (TNF)-α and vascular endothelial..Topical vitamin D3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions
British Journal of Dermatology
Jun 2012
Topical vitamin D3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions
Background: Psoriasis is a chronic inflammatory skin disease of unknown aetiology, and an active form of vitamin D3 (1α,25-dihydroxyvitamin D3) and its analogues (VD3As) are widely used topical reagents for psoriasis treatment. Besides their well-known calcium homeostasis functions, VD3As have been shown to have..Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit
British Journal of Dermatology
Jun 2012
Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit
Background: There is a lack of published evidence for treatment and outcome measures for vulval erosive lichen planus (ELPV). Objectives: To conduct a multicentre case note review to examine real-life management of ELPV comparing current U.K. practice against an agreed audit standard. Methods: Criteria for standards of..The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions
British Journal of Dermatology
Jun 2012
The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions
Background: Leprosy is complicated by immunological reactions which can occur before, during and after successful completion of multidrug therapy. Genetic studies have suggested that polymorphisms in toll-like receptors (TLRs) may affect the susceptibility of an individual with leprosy to developing Type 1 reactions...An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case–control study
British Journal of Dermatology
Jun 2012
An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case–control study
Background: Acne vulgaris is a disorder of the sebaceous follicles. Propionibacterium acnes can be involved in inflammatory acne. Objectives: This case–control study aimed at investigating the occurrence and localization of P. acnes in facial biopsies in acne and to characterize the P. acnes phylotype in skin..The south-east Scotland dermatology workload study: 30 years’ analysis
British Journal of Dermatology
Jun 2012
The south-east Scotland dermatology workload study: 30 years’ analysis
Background: Dermatological activity data have been collected for the same region of south-east Scotland (population 1·24 million), approximately every 5 years, since 1981. This has allowed assessment of trends in demand from primary and secondary care, and activity within secondary care dermatology services, assisting..Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy
British Journal of Dermatology
Jun 2012
Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy
Background: The field cancerization concept in photodamaged patients suggests that the entire sun-exposed surface of the skin has an increased risk for the development of (pre)-malignant lesions, mainly epithelial tumours. Topical photodynamic therapy (PDT) is a noninvasive therapeutic method for multiple actinic..The influence of treatments in daily clinical practice on the Children’s Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry
British Journal of Dermatology
May 2012
The influence of treatments in daily clinical practice on the Children’s Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry
Background: Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study. Objectives: To assess the Children’s Dermatology Life Quality Index (CDLQI) in a cohort of patients with..Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study
British Journal of Dermatology
May 2012
Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study
Background: Imiquimod 5% cream can reduce or clear superficial and small nodular basal cell carcinoma (BCC). It could be used as a pretreatment of Mohs micrographic surgery (MMS) to decrease defect size. Objectives: To study if a pretreatment with imiquimod 5% cream decreases defect size after MMS. In addition, to..A new concept of a multidisciplinary lymphoedema centre: established in connection to a department of dermatology and the Copenhagen Wound Healing Center
British Journal of Dermatology
May 2012
A new concept of a multidisciplinary lymphoedema centre: established in connection to a department of dermatology and the Copenhagen Wound Healing Center
Background: Lymphoedema is increasingly recognized as a significant problem in healthcare. The number of patients is growing, posing a future challenge to healthcare systems and economics. Over the past decade, specialized lymphoedema management has been established around the world to accommodate the growing demands...Detection of a rare CDKN2A intronic mutation in a Hungarian melanoma-prone family and its role in splicing regulation
British Journal of Dermatology
May 2012
Detection of a rare CDKN2A intronic mutation in a Hungarian melanoma-prone family and its role in splicing regulation
Background: The major locus for melanoma predisposition is the cell cycle regulatory CDKN2A gene on chromosome 9p21. However, the frequency of germline coding mutations of the CDKN2A gene is lower than expected in melanoma-prone families linked to chromosome 9p21. Objectives: To investigate whether the rare IVS1+37 G/C..Epitopes, avidity and IgG subclasses of tyrosine hydroxylase autoantibodies in vitiligo and alopecia areata patients
British Journal of Dermatology
May 2012
Epitopes, avidity and IgG subclasses of tyrosine hydroxylase autoantibodies in vitiligo and alopecia areata patients
Background: We previously detected antibodies against tyrosine hydroxylase (TH) in 23% of patients with nonsegmental vitiligo and in 19% of patients with alopecia areata (AA). Objectives: To identify TH epitopes recognized by TH antibodies in patients with vitiligo and AA. Methods: Recombinant plasmids containing..Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology
British Journal of Dermatology
May 2012
Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology
Background: AEC (ankyloblepharon–ectodermal defects–clefting) syndrome is an autosomal dominant ectodermal dysplasia disorder caused by mutations in the transcription factor p63. Clinically, the skin is dry and often fragile; other features can include partial eyelid fusion (ankyloblepharon), hypodontia, orofacial..The neuropeptide galanin is a novel inhibitor of human hair growth
British Journal of Dermatology
May 2012
The neuropeptide galanin is a novel inhibitor of human hair growth
Background: Galanin is a trophic factor of the central and peripheral nervous system that shows widespread distribution in human skin. However, the exact localization and the role of galanin in the hair follicle (HF) remain to be clarified. Objectives: To characterize galanin expression in human scalp HFs and to..Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong
British Journal of Dermatology
May 2012
Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong
Background: Allopurinol has been reported as a common cause of severe cutaneous adverse reactions (SCARs). Recent studies in various populations suggest that HLA-B*58:01 is a strong genetic marker for allopurinol-induced SCAR, especially in populations with a high frequency of HLA-B*58:01. Objectives: To confirm the..Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can)
British Journal of Dermatology
Apr 2012
Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can)
Background: Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC). Objectives: To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and..Assessment of serum leptin, insulin resistance and metabolic syndrome in patients with skin tags
Journal of the European Academy of Dermatology and Venereology
Dec 2011
Assessment of serum leptin, insulin resistance and metabolic syndrome in patients with skin tags
Background: Skin tags are common cutaneous lesions with an indefinite aetiology. Objectives: To assess serum leptin, insulin resistance and metabolic syndrome in different body mass index (BMI) patients with skin tags. Methods: Three equally distributed groups of patients with multiple skin tags: 30 normal BMI, 30..A randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus
Journal of the European Academy of Dermatology and Venereology
Dec 2011
A randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus
Background: To look into new potential indications for physical plasma and because some reports suggest plasma having antipruritic effects, we investigated the treatment of pruritus that often represents a therapeutic challenge. Objectives: To assess the efficacy and safety of cold atmospheric argon plasma as..Acrochordons as a cutaneous sign of impaired carbohydrate metabolism, hyperlipidemia, liver enzyme abnormalities and hypertension: a case–control study
Journal of the European Academy of Dermatology and Venereology
Dec 2011
Acrochordons as a cutaneous sign of impaired carbohydrate metabolism, hyperlipidemia, liver enzyme abnormalities and hypertension: a case–control study
Background: Acrochordons are common and benign skin tumours. A few studies with contradictory results have been reported regarding the abnormalities of carbohydrate and/or lipid metabolisms in patients with acrochordons. Objectives: We aimed to determine if the presence of acrochordons could be a marker of diabetes,..Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?
Dermatology Research and Practice
Oct 2011
Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?
Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. Immunotherapy is another targeted option. Ipilimumab, a monoclonal antibody directed to CTLA-4 present..RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy
Dermatology Research and Practice
Oct 2011
RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy
Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes. In human..Implicit processes in pathological skin picking: Responses to skin irregularities predict symptom severity and treatment susceptibility.
Journal of Behavior Therapy and Experimental Psychiatry
Sep 2011
Implicit processes in pathological skin picking: Responses to skin irregularities predict symptom severity and treatment susceptibility.
Implicit cognitive processes are relevant in understanding the development and maintenance of psychopathology and dysfunctional behaviours. The present study investigated the role of implicit processes in pathological skin picking (PSP). Using an Approach-Avoidance Task (AAT), we examined automatic response tendencies..Diagnosis of drug-induced skin reactions: a future role for computer-aided systems?
Current opinion in allergy and clinical immunology
Sep 2011
Diagnosis of drug-induced skin reactions: a future role for computer-aided systems?
Purpose of review: The diagnosis of drug-induced hypersensitivity reactions is a common clinical challenge and the skin is considered a signal organ for a large percentage of these reactions. In order to assure clinical improvement of the patient, nondermatologists in primary or intensive care settings attending to..Tumor necrosis factor biologics beyond psoriasis in dermatology
Expert opinion on biological therapy
Jun 2011
Tumor necrosis factor biologics beyond psoriasis in dermatology
Introduction: TNF-α is a cytokine essential for immune response and its receptors has been shown to be dysregulated in a variety of diseases including psoriasis vulgaris. There are a number of TNF-α inhibitors approved for psoriasis, however there is a growing body of literature supporting their use in a wide variety..Melanocortin 1 receptor and risk of cutaneous melanoma: A meta-analysis and estimates of population burden
International Journal of Cancer
Apr 2011
Melanocortin 1 receptor and risk of cutaneous melanoma: A meta-analysis and estimates of population burden
Polymorphisms in the melanocortin 1 receptor (MC1R) gene have been associated with increased risks of melanoma, but different approaches to study design, analysis, and reporting have hindered comparisons of findings. We aimed to harmonize the published data by conducting a systematic review and meta-analysis of MC1R..
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