Angiology Medical Journal Abstracts
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Local Versus Epidural Anesthesia in Fast-Track Abdominal Aortic Surgery
Journal of Cardiothoracic and Vascular Anesthesia
Jan 2013
Local Versus Epidural Anesthesia in Fast-Track Abdominal Aortic Surgery
Objective: The aim of this study was to investigate a possible alternative to epidural anesthesia/analgesia. The authors compared thoracic epidural anesthesia/analgesia with continuous wound infiltration anesthesia/analgesia in patients scheduled for mini-invasive abdominal aortic surgery in a fast-track setting...β-Blockers and Volatile Anesthetics May Attenuate Cardioprotection by Remote Preconditioning in Adult Cardiac Surgery: A Meta-analysis of 15 Randomized Trials
Journal of Cardiothoracic and Vascular Anesthesia
Jan 2013
β-Blockers and Volatile Anesthetics May Attenuate Cardioprotection by Remote Preconditioning in Adult Cardiac Surgery: A Meta-analysis of 15 Randomized Trials
Objective: Clinical trials on cardioprotection by remote ischemic preconditioning (RIPC) for adult patients undergoing cardiac surgery revealed mixed results. Previous meta-analyses have been conducted and found marked heterogeneity among studies. The aim of this meta-analysis was to evaluate the factors affecting..Frequency of Coronary Angiography and Revascularization among Men and Women with Myocardial Infarction and Their Relationship to Mortality at One Year: An Analysis of the Geisinger Myocardial Infarction Cohort
Journal of Interventional Cardiology
Dec 2012
Frequency of Coronary Angiography and Revascularization among Men and Women with Myocardial Infarction and Their Relationship to Mortality at One Year: An Analysis of the Geisinger Myocardial Infarction Cohort
Objectives: To determine sex bias in the selection of strategies to evaluate patients with acute myocardial infarction (AMI), and determine if the choice of strategy influences survival. Background: Controversy exists regarding the role of female sex in the use of invasive evaluation for AMI and its possible effect on..Aortic Valve Stenosis: To the Gradient and Beyond—The Mismatch Between Area and Gradient Severity
Journal of Interventional Cardiology
Dec 2012
Aortic Valve Stenosis: To the Gradient and Beyond—The Mismatch Between Area and Gradient Severity
The clinical severity of aortic stenosis (AS) is based largely on symptoms. However, AS severity is primarily determined by estimating the aortic valve area (AVA) and pressure gradients (ΔP). Conditions may arise in which there is a mismatch in severity between AVA and ΔP determinations secondary to errors in..A Pilot Study of Prasugrel Followed by Post-Procedural Maintenance with Clopidogrel in Patients Receiving Percutaneous Coronary Intervention
Journal of Interventional Cardiology
Dec 2012
A Pilot Study of Prasugrel Followed by Post-Procedural Maintenance with Clopidogrel in Patients Receiving Percutaneous Coronary Intervention
Background: Dual anti-platelet therapy including clopidogrel or prasugrel is standard of care for patients receiving stents. Prasugrel has quicker onset so it can be loaded later than clopidogrel with greater efficacy. However, prasugrel is much more expensive than clopidogrel. Objectives: To describe the incidence of..25-hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18,791 participants
Journal of Thrombosis and Haemostasis
Dec 2012
25-hydroxyvitamin D concentrations and risk of venous thromboembolism in the general population with 18,791 participants
Background: Vitamin D has potential antithrombotic effects suggesting that vitamin D analogs could be used as adjunctive antithrombotic agents. However, epidemiological evidence of an association between reduced 25-hydroxyvitamin D concentrations and risk of venous thromboembolism is lacking. Objectives: We tested the..Platelet dysfunction associated with the novel Trp29Cys thromboxane A2 receptor variant
Journal of Thrombosis and Haemostasis
Dec 2012
Platelet dysfunction associated with the novel Trp29Cys thromboxane A2 receptor variant
Background: Genetic variations that affect the structure of the thromboxane A2 (TP) receptor provide insights into the function of this key platelet and vascular receptor, but are very rare in unselected populations. Objectives: To determine the functional consequences of the TP receptor Trp29Cys (W29C) substitution...Rituximab for thrombotic thrombocytopenic purpura (TTP): benefit of early administration during acute episodes and use of prophylaxis to prevent relapse
Journal of Thrombosis and Haemostasis
Dec 2012
Rituximab for thrombotic thrombocytopenic purpura (TTP): benefit of early administration during acute episodes and use of prophylaxis to prevent relapse
Background: Rituximab has been documented in the treatment of acute (≤3 days from admission), relapsed/refractory TTP and given as prophylaxis in selected cases to prevent acute relapse. The precise timing of Rituximab in acute TTP has not been determined. Objective: To perform a retrospective analysis of rituximab use..Coagulation and cancer: biological and clinical aspects
Journal of Thrombosis and Haemostasis
Dec 2012
Coagulation and cancer: biological and clinical aspects
Malignancy affects the haemostatic system and the haemostatic system affects malignancy. In cancer patients there are a number of coagulation abnormalities which provide the background for an increased tendency of these patients to both thrombosis and haemorrhages. The causes of this coagulation impairment rely on..New Developments in the Area of Factor XIII
Journal of Thrombosis and Haemostasis
Dec 2012
New Developments in the Area of Factor XIII
Coagulation factor XIII (FXIII) is best known for its role in fibrin stabilization and crosslinking of antifibrinolytic proteins to the fibrin clot. From patients with congenital FXIII deficiency it was known that FXIII also has important functions in wound healing and maintaning pregnancy. Over the last decade more..Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components
Journal of Thrombosis and Haemostasis
Dec 2012
Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components
Background: Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate CS, dermatan sulfate DS) and expose extracellular matrix (ECM) proteins (e.g. decorin) at sites of fibrin formation. Objective: Here we address the effect of these vessel wall..Prospective, multicenter validation of prediction scores for major bleeding in elderly patients with venous thromboembolism
Journal of Thrombosis and Haemostasis
Dec 2012
Prospective, multicenter validation of prediction scores for major bleeding in elderly patients with venous thromboembolism
Background: The Outpatient Bleeding Risk Index (OBRI) and the Kuijer, RIETE, and Kearon scores are clinical prognostic scores for bleeding in patients receiving oral anticoagulants for venous thromboembolism (VTE). We prospectively compared the performance of these scores in elderly patients with VTE. Methods: In a..Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study
Journal of Cardiothoracic and Vascular Anesthesia
Dec 2012
Influence of Acidosis on Cardiotonic Effects of Colforsin and Epinephrine: A Dose-Response Study
Objective: Acidosis produces a negative inotropic effect on cardiac muscle against which catecholamines and phosphodiesterase III inhibitors have limited therapeutic effects. This study evaluated the effects of colforsin, which directly activates adenylate cyclase without β-adrenergic receptor activation, in isolated..Sevoflurane Confers Additive Cardioprotection to Ethanol Preconditioning Associated With Enhanced Phosphorylation of Glycogen Synthase Kinase-3β and Inhibition of Mitochondrial Permeability Transition Pore Opening
Journal of Cardiothoracic and Vascular Anesthesia
Dec 2012
Sevoflurane Confers Additive Cardioprotection to Ethanol Preconditioning Associated With Enhanced Phosphorylation of Glycogen Synthase Kinase-3β and Inhibition of Mitochondrial Permeability Transition Pore Opening
Objective: The purposes of this study were to investigate whether sevoflurane (SEVO) enhances moderate-dose ethanol (EtOH) preconditioning and whether this additional cardioprotection is associated with glycogen synthase kinase-3β (GSK-3β), protein kinase B (Akt), mammalian target of rapamycin (mTOR), 70-kDa ribosomal..Quantification of circulating CD34+/KDR+/CD45dim endothelial progenitor cells: Analytical considerations
International Journal of Cardiology
Nov 2012
Quantification of circulating CD34+/KDR+/CD45dim endothelial progenitor cells: Analytical considerations
The discovery of peripheral circulating cells that contribute to vasculogenesis and endothelial repair was one of the most fascinating breakthroughs in the domain of vascular research during the last two decades. The population of vasculogenic cells however, is heterogeneous and can be analyzed using different..Drug adherence and the incidence of coronary heart disease- and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication: A five-year cohort study
International Journal of Cardiology
Nov 2012
Drug adherence and the incidence of coronary heart disease- and stroke-specific mortality among 218,047 patients newly prescribed an antihypertensive medication: A five-year cohort study
Background: Randomized trials have shown that optimal adherence to antihypertensive agents could protect against cardiovascular diseases, but whether adherence reduces cardiovascular deaths in community settings has not been explored so fully. This study evaluates the association between antihypertensive adherence and..Anterior ECG changes following iatrogenic dissection of the right coronary artery into the aortic root: Exclusion of left coronary obstruction with transoesophageal echocardiography
Cardiovascular Revascularization Medicine
Nov 2012
Anterior ECG changes following iatrogenic dissection of the right coronary artery into the aortic root: Exclusion of left coronary obstruction with transoesophageal echocardiography
One of the most troublesome complications of percutaneous coronary intervention (PCI) or angiography is retrograde dissection of the artery into the aortic root. We report a case involving the right coronary artery (RCA) which was treated with prompt deployment of stents. Recurrent chest pain and ST segment elevation..Real Incidence of Diabetes Mellitus in a Coronary Disease Population
American Journal of Cardiology
Nov 2012
Real Incidence of Diabetes Mellitus in a Coronary Disease Population
The high prevalence of unknown diabetes mellitus (DM) in patients with coronary disease and that the oral glucose tolerance test (OGTT) is the best diagnostic method in this context are well known. However, data about the incidence of DM in this population have not been well described. In the present study, we sought..Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-lowering (CPC) Study
American Journal of Cardiology
Nov 2012
Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-lowering (CPC) Study
Although the effect of niacin on the glucose levels in subjects with diabetes mellitus has been investigated, niacin’s effects on the glucose levels and atherosclerosis in subjects with normal glucose levels have not been well established. We examined the effect of niacin on the glucose levels, coronary stenosis..Relation of Morbid Obesity and Female Gender to Risk of Procedural Complications in Patients Undergoing Atrial Fibrillation Ablation
American Journal of Cardiology
Nov 2012
Relation of Morbid Obesity and Female Gender to Risk of Procedural Complications in Patients Undergoing Atrial Fibrillation Ablation
Obese patients with atrial fibrillation (AF) are frequently treated with AF ablation. We sought to examine whether a body mass index (BMI) threshold exists beyond which the odds of experiencing a complication from AF ablation increases. All patients enrolled in the Vanderbilt AF Registry who underwent catheter-based AF..Indexes of von Willebrand Factor as Biomarkers of Aortic Stenosis Severity (from the Biomarkers of Aortic Stenosis Severity [BASS] Study)
American Journal of Cardiology
Nov 2012
Indexes of von Willebrand Factor as Biomarkers of Aortic Stenosis Severity (from the Biomarkers of Aortic Stenosis Severity [BASS] Study)
We correlated von Willebrand factor (VWF) activity indexes and brain natriuretic peptide (BNP) with measures of aortic stenosis (AS) severity, bleeding, symptoms, and freedom from death or aortic valve replacement. Patients with AS (n = 66 [16 mild, 20 moderate, and 30 severe]) and aortic valve replacement (n = 21)..Refining the Role of Antiplatelet Therapy in Medically Managed Patients With Acute Coronary Syndrome
American Journal of Cardiology
Nov 2012
Refining the Role of Antiplatelet Therapy in Medically Managed Patients With Acute Coronary Syndrome
Dual-antiplatelet therapy with aspirin plus a P2Y12 receptor inhibitor is recommended for use as first-line therapy in patients with acute coronary syndromes (ACS) who undergo high-risk percutaneous coronary intervention. However, revascularization may not be a beneficial option for some subgroups of patients with ACS...Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score
American Journal of Cardiology
Nov 2012
Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score
Despite the existence of several risk scores, the accurate prediction of the prognosis in pulmonary embolism (PE) remains a challenge. The Global Registry of Acute Coronary Events (GRACE) risk score has a high diagnostic performance for adverse outcomes in acute coronary syndrome. We aimed to assess the applicability..Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: Results from the COMPERA registry
International Journal of Cardiology
Nov 2012
Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: Results from the COMPERA registry
Background: Originally reported to occur predominantly in younger women, idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients. We aimed to describe the characteristics of such patients and their survival under clinical practice conditions. Methods: Prospective registry in 28..Intravascular ultrasound assessed incomplete stent apposition and stent fracture in stent thrombosis after bare metal versus drug-eluting stent treatment the Nordic Intravascular Ultrasound Study (NIVUS)
International Journal of Cardiology
Nov 2012
Intravascular ultrasound assessed incomplete stent apposition and stent fracture in stent thrombosis after bare metal versus drug-eluting stent treatment the Nordic Intravascular Ultrasound Study (NIVUS)
Background: This prospective multicenter registry used intravascular ultrasound (IVUS) in patients with definite stent thrombosis (ST) to compare rates of incomplete stent apposition (ISA), stent fracture and stent expansion in patients treated with drug-eluting (DES) versus bare metal (BMS) stents. ST is a rare, but..Early intravenous beta-blockers in patients with acute coronary syndrome—A meta-analysis of randomized trials
International Journal of Cardiology
Nov 2012
Early intravenous beta-blockers in patients with acute coronary syndrome—A meta-analysis of randomized trials
Background: Intravenous (IV) beta-blockade is currently a Class IIa recommendation in early management of patients with acute coronary syndromes (ACS) without obvious contraindications. Methods: We searched the PubMed, EMBASE and the Cochrane Register for Controlled Clinical Trials for randomized clinical trials from..Validation of contemporary stroke and bleeding risk stratification scores in non-anticoagulated Chinese patients with atrial fibrillation
International Journal of Cardiology
Nov 2012
Validation of contemporary stroke and bleeding risk stratification scores in non-anticoagulated Chinese patients with atrial fibrillation
Background: Risk stratification schemes assessing stroke and thromboembolism (stroke/TE) and bleeding relating to atrial fibrillation (AF) have largely been derived and validated in Western populations. We assessed risk factors that constitute scores for assessing stroke/TE (CHADS2, CHA2DS2-VASc) and bleeding..CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-γ-dependent autophagy
International Journal of Cardiology
Nov 2012
CXCR6 deficiency ameliorated myocardial ischemia/reperfusion injury by inhibiting infiltration of monocytes and IFN-γ-dependent autophagy
Background: Emerging evidence shows that the chemokine CXCL16 plays an important role in the pathogenesis of myocardial remodeling and development of heart failure following ischemia/reperfusion (I/R) injury. CXCR6, the receptor for CXCL16, is also critically involved. However, the underlying mechanism remained..Risk Modelling in Quality Clinical Registries: Monitoring Lesion Treatment Failure Rate in Percutaneous Coronary Interventions
Heart, Lung and Circulation
Nov 2012
Risk Modelling in Quality Clinical Registries: Monitoring Lesion Treatment Failure Rate in Percutaneous Coronary Interventions
Aims: This paper describes the development of a risk adjustment (RA) model predictive of individual lesion treatment failure in percutaneous coronary interventions (PCI) for use in a quality monitoring and improvement program. Methods and results: Prospectively collected data for 3972 consecutive revascularisation..The identification and management of heparin-induced thrombocytopenia in the vascular patient
Journal of Vascular Surgery
Dec 2011
The identification and management of heparin-induced thrombocytopenia in the vascular patient
Heparin-induced thrombocytopenia (HIT) is a serious, acquired, prothrombotic disorder caused by an antibody response to the heparin-platelet factor 4 complex, which can precipitate arterial as well as venous thromboembolic complications. HIT should be suspected in patients exposed to heparin who present with an..Angiogenesis between coronary grafts through the aortic wall
International Journal of Cardiology
Dec 2011
Angiogenesis between coronary grafts through the aortic wall
Following a total coronary occlusion, residual perfusion to the myocardium persists through native coronary collateral channels. ..Left ventricular dynamic gradient and pericardial effusion. A life threatening combination in patients with apical ballooning syndrome
International Journal of Cardiology
Dec 2011
Left ventricular dynamic gradient and pericardial effusion. A life threatening combination in patients with apical ballooning syndrome
Although most complications of apical ballooning syndrome (ABS) are known, data regarding its incidence in series of patients is scanty...Coronary collateral growth—back to the future
Journal of Molecular and Cellular Cardiology
Dec 2011
Coronary collateral growth—back to the future
The coronary collateral circulation is critically important as an adaptation of the heart to prevent the damage from ischemic insults. In their native state, collaterals in the heart would be classified as part of the microcirculation, existing as arterial-arterial anastomotic connections in the range of 30 to 100μM in..Balloon angioplasty vs nitinol stent placement in the treatment of venous anastomotic stenoses of hemodialysis grafts after surgical thrombectomy
Journal of Vascular Surgery
Dec 2011
Balloon angioplasty vs nitinol stent placement in the treatment of venous anastomotic stenoses of hemodialysis grafts after surgical thrombectomy
Objective: Most arteriovenous hemodialysis grafts fail ≤18 months after implantation, most commonly due to intimal hyperplasia at the venous anastomosis. This open prospective study compared balloon angioplasty vs nitinol stent placement in the treatment of venous anastomotic stenosis after thrombectomy of prosthetic..Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against Ischemia/Reperfusion Injury
Experimental Diabetes Research
Nov 2011
Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against Ischemia/Reperfusion Injury
Ischemic preconditioning (IPC) or postconditioning (Ipost) is proved to efficiently prevent ischemia/reperfusion injuries. Mortality of diabetic patients with acute myocardial infarction was found to be 2-6 folds higher than that of non-diabetic patients with same myocardial infarction, which may be in part due to..The chylomicron: relationship to atherosclerosis
International Journal of Vascular Medicine
Oct 2011
The chylomicron: relationship to atherosclerosis
The B-containing lipoproteins are the transporters of cholesterol, and the evidence suggests that the apo B48-containing postprandial chylomicron particles and the triglyceride-rich very low density lipoprotein (VLDL) particles play an important part in the development of the plaque both directly and indirectly by..The Course of Fatigue during the First 18 Months after First-Ever Stroke: A Longitudinal Study
Stroke Research and Treatment
Oct 2011
The Course of Fatigue during the First 18 Months after First-Ever Stroke: A Longitudinal Study
Background: Little is known about the course of poststroke fatigue. Objectives: To describe the course of poststroke fatigue in relation to the patient's level of physical functioning, depressive symptoms, and self-reported history of prestroke fatigue. Methods: A longitudinal study using structured face-to-face..Altered resting-state effective connectivity of fronto-parietal motor control systems on the primary motor network following stroke
NeuroImage
Aug 2011
Altered resting-state effective connectivity of fronto-parietal motor control systems on the primary motor network following stroke
Previous brain imaging work suggests that stroke alters the effective connectivity (the influence neural regions exert upon each other) of motor execution networks. The present study examines the intrinsic effective connectivity of top-down motor control in stroke survivors (n=13) relative to healthy participants..Free wall rupture (FWR) in patients with acute ST-elevation myocardial infarction (STEMI) receiving fibrinolytic therapy (FT): A 7-year prospective study.
Archives of Gerontology and Geriatrics
Apr 2011
Free wall rupture (FWR) in patients with acute ST-elevation myocardial infarction (STEMI) receiving fibrinolytic therapy (FT): A 7-year prospective study.
Previous studies have shown a paradoxical increase in early mortality in older patients (>70 years) with acute STEMI treated with fibrinolytic therapy (FT), which has been attributed to the development of free wall rupture (FWR). Our aim was to assess occurrence of FWR in STEMI patients receiving FT. In this 7-year..Prior antiplatelet drug use and short-term mortality in older patients with acute ischemic stroke (AIS)
Archives of Gerontology and Geriatrics
Feb 2011
Prior antiplatelet drug use and short-term mortality in older patients with acute ischemic stroke (AIS)
Some studies suggest that previous treatment with antiplatelet agents (AA) might reduce ischemic stroke severity and improve outcomes in terms of clinical deficits or mortality. We evaluated the effect of the prior chronic use of AA on short-term (30 days) mortality in a sample of consecutive patients with AIS. Four..
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