Medical Journal Abstracts

Overview

The medical journal abstracts section provides healthcare professionals with access to key journal abstracts. Bringing together articles from a full range of sources, this resource aims to provide doctors with a starting point for their journal research.

The regularly updated journals can be sorted by disease/condition, source name and the date of publication. Alternatively they can be accessed within the relevant epgonline.org disease topic areas, via the collapsible menu at the top of each page of the epgonline.org website.

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Acta Paediatrica

Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents

Acta Paediatrica (Feb 2013)

Aim: This study was designed to evaluate the diagnostic value of B-type natriuretic peptide (BNP) in syncope in children and adolescents. Methods: Serum BNP concentration was measured by electrochemiluminescence assay in 62 consecutive children and adolescents hospitalized for syncope. Results: Of the 62 children and...

Have the boundaries of the ‘grey zone’ of perinatal resuscitation changed for extremely preterm infants over 20 years?

Acta Paediatrica (Jan 2013)

Aim: To determine the boundaries of the grey zone of discretionary resuscitation over the past 20 years. Background: As the likelihood of survival improves over time, the BW- and GA-specific boundaries of discretionary nonresuscitation should fall. Hypothesis: Between 1988 and 2008 reductions in BW- and GA-specific...

Early colour Doppler duct diameter and symptomatic patent ductus arteriosus in a cyclo-oxygenase inhibitor naïve population

Acta Paediatrica (Jan 2013)

Aims: To examine the relationship between early duct diameter and patent ductus arteriosus (PDA) symptoms. Methods: A retrospective study of infants <29 weeks of gestation with early colour Doppler assessment of PDA diameter, in whom PDA was managed conservatively, without cyclo-oxygenase inhibitor (COI) treatment....

Impact of nursing care on temperature environment in preterm newborns nursed in closed convective incubators

Acta Paediatrica (Jan 2013)

Aims: Very-low-birth-weight (VLBW) neonates require regular nursing procedures with frequent opening of the incubator resulting in a decrease in incubator air temperature. This study was designed to assess changes in the thermal status of VLBW neonates according to the type of nursing care and incubator openings....

Prospective antibody case finding of coeliac disease in type-1 diabetes children: need of biopsy revisited

Acta Paediatrica (Jan 2013)

Aim: To evaluate whether coeliac disease (CD) can be diagnosed by measuring autoantibodies without small-intestinal mucosal biopsies in children with type 1 diabetes. Methods: Case finding of CD was undertaken in 181 consecutive IgA-competent children with type 1 diabetes using transglutaminase 2 (TG2) and endomysial...

Congenital cataract screening in maternity wards is effective: evaluation of the Paediatric Cataract Register of Sweden

Acta Paediatrica (Dec 2012)

Aim: To study which eye-screening protocol prevails in Swedish maternity/neonatal wards, evaluate efficacy in a prospective study and compare results with earlier Swedish retrospective results. Methods: Surveys were sent in 2006 to maternity/neonatal and women's health departments regarding screening policy. Response...

Shared physical custody after family split-up: implications for health and well-being in Swedish schoolchildren

Acta Paediatrica (Dec 2012)

Aim: In Sweden, shared physical custody following a parental separation has emerged as means for children to keep close relationships with both parents. Previous studies show that children benefit from regular contact with both parents, who share responsibility for their social, emotional and economic welfare. In this...

Fatty liver is a good indicator of subclinical atherosclerosis risk in obese children and adolescents regardless of liver enzyme elevation

Acta Paediatrica (Dec 2012)

Aim: To investigate the presence of association between nonalcoholic fatty liver disease (NAFLD) and subclinical atherosclerosis using carotid intima media thickness (c-IMT) in obese children and adolescents. Additionally, we wished to investigate the relationship between fatty liver and elevated liver enzymes....

Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study

Acta Paediatrica (Dec 2012)

Aim: Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD). Methods: Any child <15 years hospitalized with an HD diagnosis of BJI, alone or in combination with sepsis or...

Self-perceived health status and mental health outcomes in young adults born with less than 1000 g

Acta Paediatrica (Dec 2012)

Aim: To assess self-perceived health status and mental health outcomes of former extremely low-birth-weight (ELBW) infants at young adulthood compared with community norms and to analyse predictors of poor outcome. Methods: Fifty-five ELBW adults, 18 men (33%), with median (range) gestational age of 28.7 (25.0–34.0)...

Extremely low birthweight infants: how neonatal intensive care unit teams can reduce postnatal malnutrition and prevent growth retardation

Acta Paediatrica (Dec 2012)

Aim: To evaluate the impact of an improved nutritional policy for extremely low birthweight (ELBW) infants on nutritional deficits and postnatal growth. Method: We compared two groups of 37 ELBW infants, born before and after the introduction of an improved nutritional policy in April 2006. Group A (born 2005 to early...

Hospital-wide breastfeeding rates vs. breastmilk provision for very-low-birth-weight infants

Acta Paediatrica (Dec 2012)

Aim: To investigate the relationship between breastmilk feeding in very-low-birth-weight infants in the neonatal intensive care unit and breastmilk feeding rates for all newborns by hospital. Methods: This was a cross-sectional study of 111 California hospitals in 2007 and 2008. Correlation coefficients were calculated...

Evolution of overweight prevalence among 5–6-year-old children according to socio-economic status

Acta Paediatrica (Dec 2012)

Aim: To assess time trends in overweight and obesity prevalence among 5–6-year-old children of Bordeaux city (France) over seven school years from 2004–2005 to 2010–2011. Methods: For each year, all 5–6-year-old children from 63 of the 69 schools of Bordeaux were included: 2005, 2100, 2010, 1952, 2040, 2017 and 2111...

Preterm birth and unintentional injuries: risks to children, adolescents and young adults show no consistent pattern

Acta Paediatrica (Dec 2012)

Aim: Preterm birth is associated with a number of physical and mental health issues. The aim of this study was to find out whether there was also any association between individuals born preterm in Sweden between 1984 and 2006 and the risk of unintentional injuries during childhood, adolescence and young adulthood....

Is there any correlation between HLA-DR expression in laryngeal mucosa and interleukin gene variation in sudden infant death syndrome?

Acta Paediatrica (Dec 2012)

Aim: The mucosal immune system and cytokines are activated in a large proportion of cases of sudden infant death syndrome (SIDS). Our aim was to search for a possible association between cytokine polymorphisms and immune stimulation of the laryngeal mucosal in SIDS. Methods: HLA-DR expression in laryngeal mucosal...

Self-rated and parent-rated quality of life (QoL) for community-based obese and overweight children

Acta Paediatrica (Dec 2012)

Aims: To determine the effects of being obese or overweight on quality of life (QoL) of children from a community-based sample and to compare their self-ratings of QoL with their parents' ratings for their children's QoL. Methods: Dyads of 8- to 12-year-old children [60 obese, 34 overweight and 127 normal weight (N =...

Physical and social functioning in adolescents with rheumatological conditions: a study of predictors

Acta Paediatrica (Dec 2012)

Aim: This study examines possible predictors of physical and social functioning in adolescents with rheumatological conditions. Condition-related variables and psychosocial variables were studied, and their relative contribution as predictors was examined. Methods: The study population was one hundred and twelve...

Neonatal and parental predictors of executive function in very preterm children

Acta Paediatrica (Dec 2012)

Aim: To examine neonatal and parental predictors of executive function in very preterm (gestational age ≤30 weeks) children aged 4.0–12.0 years. Methods: Two-hundred very preterm (mean age 8.2 ± 2.5 years) children without severe disabilities, born between 1996 and 2004, were assessed with measures of executive...

Secular trends in weight, height and BMI in young Swedes: The ‘Grow up Gothenburg’ Studies

Acta Paediatrica (Dec 2012)

Aim: This study aims to document secular differences in anthropometry (level and variability of weight, height, BMI) in two cohorts born around 1990 and 1974 and examined as young adults. Methods: Descriptive results are presented for the complete cohorts. The final analysis age-matched the cohorts (mean, 18.8 years)...

Use of heated humidified high-flow nasal cannula oxygen in neonates: a UK wide survey

Acta Paediatrica (Dec 2012)

Aim: Heated humidified high-flow nasal cannula (HHHFNC) oxygen is a relatively new form of respiratory support and is increasing in popularity despite lack of supportive evidence and amid safety concerns. We investigated the prevalence of its use in tertiary neonatal units in the UK. Method: Electronic survey. Results:...

Follow-up study of 2-year-olds born at very low gestational age in Estonia

Acta Paediatrica (Dec 2012)

Aim: To study very low gestational age (VLGA, <32 weeks) infants at 2 years of age and to identify the predictors of adverse outcomes. Methods: A population-based cohort of 155 surviving VLGA infants born in Estonia in 2007 was followed up and compared with a matched full-term (FT) control group. A logistic regression...

Addiction

Decline in incidence of HIV and Hepatitis C virus infection among injecting drug users in Amsterdam; evidence for harm reduction?

Addiction (Jan 2013)

Aims: In Amsterdam HIV prevalence has nearly halved among Injecting Drug Users (IDU) since 1990. Hepatitis C Virus (HCV) prevalence also declined, HIV and HCV incidence dropped to nearly zero. We examined possible explanations for these time trends, among which the implementation of harm reduction measures aimed at...

Global alcohol exposure estimates by country, territory and region for 2005 – a contribution to the Comparative Risk Assessment for the 2010 Global Burden of Disease Study

Addiction (Jan 2013)

Aims: This study aimed to estimate the prevalence of lifetime abstainers, former drinkers and current drinkers, adult per capita consumption of alcohol, and pattern of drinking scores, by country and Global Burden of Disease region for 2005, and to forecast these indicators for 2010. Design: Statistical modelling based...

Extended release methylphenidate for treatment of amphetamine/methamphetamine dependence: a randomised, double-blind, placebo controlled trial

Addiction (Jan 2013)

Aims: To assess the efficacy of methylphenidate as a substitution therapy for amphetamine/methamphetamine dependence in Finland and New Zealand. Design: parallel group, double-blind, randomised placebo controlled trial. Setting: outpatient care. Participants: amphetamine/methamphetamine dependent, aged 16-65....

Advances in experimental medicine and biology

Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1

Advances in experimental medicine and biology (Sep 2011)

The realization of a major role for events that occur during acute viremia that dictate the course of disease both in HIV-1 infected humans and susceptible SIV infected non-human primates has prompted an intense interest in studies of the contribution of innate immune effector mechanisms. It is reasoned that findings...

Advances in Urology

Circulating and disseminated tumor cells in the management of advanced prostate cancer.

Advances in Urology (Aug 2011)

Management of prostate cancer is recognized as one of the most important medical problems. Latest findings concerning the role of circulating (CTC) and disseminated tumor cells (DTC) have provided new insights into the biology of metastasis with important implications for the clinical management of prostate cancer...

Radiographic Evaluation of Children with Febrile Urinary Tract Infection: Bottom-Up, Top-Down, or None of the Above?

Advances in Urology (Aug 2011)

The proper algorithm for the radiographic evaluation of children with febrile urinary tract infection (FUTI) is hotly debated. Three studies are commonly administered: renal-bladder ultrasound (RUS), voiding cystourethrogram (VCUG), and dimercapto-succinic acid (DMSA) scan. However, the order in which these tests are...

Aesthetic Surgery Journal

The Efficacy and Safety of DepoFoam Bupivacaine in Patients Undergoing Bilateral, Cosmetic, Submuscular Augmentation Mammaplasty: A Randomized, Double-Blind, Active-Control Study

Aesthetic Surgery Journal (Dec 2011)

Background: Breast augmentation can result in significant postsurgical pain. Objectives: The authors evaluate the extent and duration of analgesia achieved with extended-release DepoFoam bupivacaine (Pacira Pharmaceuticals, Inc., Parsippany, New Jersey) in patients undergoing bilateral, cosmetic, submuscular...

Impact of the Current Economy on Facial Aesthetic Surgery

Aesthetic Surgery Journal (Aug 2011)

Background: American Society for Aesthetic Plastic Surgery (ASAPS) survey data showed a 16.7% decrease in the total number of aesthetic surgical procedures from 2008 to 2009, whereas plastic surgeons have seen an increase of 0.6% in their nonsurgical cosmetic procedures. Objective: The authors describe the results of...

Ageing and Society

How the lifecycle hypothesis explains volunteering during retirement

Ageing and Society (Nov 2011)

We suggest two supplements to Franco Modigliani's lifecycle model in order to explain why people who have retired from paid work choose either to start volunteering or increase the amount of time they devote to volunteer work. First, total consumption consists of both the material and immaterial products of work. While...

Ageing Cell

Deviation of innate circadian period from 24 hours reduces longevity in mice

Ageing Cell (Jun 2012)

The variation of individual life spans, even in highly inbred cohorts of animals and under strictly controlled environmental conditions, is substantial and not well understood. This variation in part could be due to epigenetic variation, which later affects the animal’s physiology and ultimately longevity....

High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer’s disease

Ageing Cell (Jun 2012)

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that impairs mnesic functions. The histopathology of the disease is manifested by the accumulation of intracellular β-amyloid (Aβ) and subsequent formation of neuritic plaques as well as the presence neurofibrillary tangles in specific brain regions...

AIDS Research and Treatment

The Direct Medical Costs of Late Presentation (<350/mm) of HIV Infection over a 15-Year Period.

AIDS Research and Treatment (Aug 2011)

We describe the immediate- and longer-term direct medical costs of care for individuals diagnosed with HIV at CD4 counts <350/mm3 (“late presenters”). We collected and stratified by initial CD4 count all inpatient, outpatient, and drug costs for all newly diagnosed patients accessing HIV care within Southern Alberta...

Allergy

The dynamics of herpesvirus reactivations during and after severe drug eruptions: their relation to the clinical phenotype and therapeutic outcome

Allergy (Apr 2014)

Background:

Drug–induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS) and Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represent contrasting poles of severe drug eruptions, and sequential reactivations of several herpesviruses have...

Systematic review on cashew nut allergy

Allergy (Apr 2014)

Recent studies on cashew nut allergy suggest that the prevalence of cashew nut allergy is increasing. Cashew nut consumption by allergic patients can cause severe reactions, including anaphylaxis. This review summarizes current knowledge on cashew nut allergy to facilitate timely clinical recognition and to promote...

Asthma control assessment in a pediatric population: comparison between GINA/NAEPP guidelines, Childhood Asthma Control Test (C–ACT), and physician's rating

Allergy (Apr 2014)

Background:

Guidelines recommend regular assessment of asthma control. The Childhood Asthma Control Test (C–ACT) is a clinically validated tool.

Aim:

To evaluate asthma control according to GINA2006, NAEPP, pediatrician's assessment (PA), and C–ACT in asthmatic children visiting their...

Job strain and the risk of severe asthma exacerbations: a meta–analysis of individual–participant data from 100 000 European men and women

Allergy (Apr 2014)

Background:

Many patients and healthcare professionals believe that work–related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in...

Biphasic anaphylactic reactions: occurrence and mortality

Allergy (Apr 2014)

Background:

Monitoring after complete resolution of anaphylactic reactions is recommended. The aim of this study was to define the occurrence of biphasic – and clinically important biphasic – anaphylactic reactions, the number of transfers to intensive care units (ICU) because of anaphylaxis, and...

Hypersensitivity and desensitization to antineoplastic agents: outcomes of 189 procedures with a new short protocol and novel diagnostic tools assessment

Allergy (May 2013)

Background: Desensitization to antineoplastic agents is becoming a standard of care. Efforts to establish and improve these techniques are being made at many institutions. Our aims are to evaluate a new rapid desensitization protocol designed to be shorter (approximately 4 h) and safer (reducing hazardous drugs...

Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models

Allergy (Dec 2012)

Background: Allergy is an acquired hypersensitivity reaction of the immune system mediated by cross-linking of allergen-specific IgE-bound high-affinity IgE receptors, leading to immediate mast cell degranulation. Artesunate is a semi-synthetic derivative of artemisinin, an active component of the medicinal plant...

Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model

Allergy (Dec 2012)

Background: Sphingosine-1-phosphate (S1P) plays a crucial role in homeostasis of the immune system by regulating lymphocyte recirculation and inflammatory cell recruitment. The levels of S1P are tightly controlled through regulated production and controlled breakdown by sphingosine-lyase (SL). The S1P analogue FTY720...

Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study

Allergy (Dec 2012)

Background: Vitamin D levels are known to be associated with atopic disease development; however, existing data are controversial. The aim of this study was to investigate whether corresponding maternal and cord blood vitamin D levels are associated with atopic outcomes in early infancy. Methods: Within the LINA cohort...

Characteristics of anaphylaxis-inducing IgG immune complexes triggering murine passive systemic anaphylaxis

Allergy (Dec 2012)

Background: With the broad and increasing application of therapeutic monoclonal antibodies (mAbs) in clinical settings, IgG-induced allergic reactions, including passive systemic anaphylaxis (PSA), have attracted significant attention. However, it is not clear which types of IgG mAb–antigen complexes or IgG aggregates...

Mechanisms of peripheral tolerance to allergens

Allergy (Dec 2012)

The immune system is regulated to protect the host from exaggerated stimulatory signals establishing a state of tolerance in healthy individuals. The disequilibrium in immune regulatory vs effector mechanisms results in allergic or autoimmune disorders in genetically predisposed subjects under certain environmental...

A multicenter, randomized, controlled trial testing the effects of acupuncture on allergic rhinitis

Allergy (Dec 2012)

Background: The aim of this study was to evaluate the efficacy and safety of acupuncture in the treatment for allergic rhinitis. Methods: This study was a multicenter, randomized, parallel-controlled study. Participants were randomized to either the active acupuncture, sham acupuncture, or waitlist groups. The active...

Substance P antagonist improves both obesity and asthma in a mouse model

Allergy (Nov 2012)

Background: Evidence suggests a causal relationship between obesity and asthma; however, the underlying mechanisms remain unknown. Substance P (SP), involved in neurogenic inflammation by acting through its receptor NK1-R, seems to participate in obese–asthma phenotype in mice. Objectives: To evaluate the effect of a...

Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA 2 LEN survey

Allergy (Nov 2012)

Background: Asthma and rhinitis have been related to insomnia. The aim of this study was to further analyse the association between asthma, nasal symptoms and insomnia and to identify risk factors for sleep disturbance among patients with asthma, in a large population-based set of material. Method: In 2008, a postal...

Asthma severity in childhood and metabolomic profiling of breath condensate

Allergy (Nov 2012)

Background: Asthma is a heterogeneous disease and its different phenotypes need to be better characterized from a biochemical-inflammatory standpoint. This study aimed to apply the metabolomic approach to exhaled breath condensate (breathomics) to discriminate different asthma phenotypes, with a particular focus on...

Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns

Allergy (Nov 2012)

Background: The remodeling patterns in different types of chronic rhinosinusitis (CRS) have rarely been compared, particularly the difference between eosinophilic and noneosinophilic CRS with nasal polyps (CRSwNP). Moreover, whether there is a link between remodeling and inflammation remains controversial. Objective:...

EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria

Allergy (Nov 2012)

An autoimmune subset of chronic spontaneous urticaria is increasingly being recognized internationally, based on laboratory and clinical evidence that has accrued over the last 20 years. This evidence has been reviewed by a taskforce of the Dermatology section of the European Academy of Allergy and Clinical Immunology....

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

Allergy (Nov 2012)

Background: Defects in keratinocyte differentiation and skin barrier are important features of inflammatory skin diseases like atopic dermatitis. Mast cells and their main mediator histamine are abundant in inflamed skin and thus may contribute to disease pathogenesis. Methods: Human primary keratinocytes were cultured...

Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps

Allergy (Nov 2012)

Background: Chronic rhinosinusitis with nasal polyps (NP) and allergic rhinitis (AR) is characterized by local Th2 inflammation and up-regulation of IgE; however, IgE in NP is ‘polyclonal’ and allergen specific, whereas IgE in AR is ‘oligoclonal’ and allergen specific. Germinal center (GC) reactions occur in AR, while...

Phosphodiesterase-4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress

Allergy (Nov 2012)

Background: Several clinical studies have shown that smoking in asthmatics and chronic obstructive pulmonary disease patients is closely associated with corticosteroid refractoriness. In this work, we have analyzed glucocorticoid insensitivity in human pulmonary artery endothelial cells (HPAECs) under cigarette smoke...

Recombinant human C1 inhibitor for the prophylaxis of hereditary angioedema attacks: a pilot study

Allergy (Nov 2012)

Background: Hereditary angioedema (HAE) is a disease characterized by recurrent tissue swelling affecting various body locations. Recent literature shows that patients with frequent attacks may benefit from long-term prophylaxis. This study evaluated the safety and prophylactic effect of weekly administrations of...

Novel insights into mechanisms of food allergy and allergic airway inflammation using experimental mouse models

Allergy (Oct 2012)

Over the last decades, considerable efforts have been undertaken in the development of animal models mimicking the pathogenesis of allergic diseases occurring in humans. The mouse has rapidly emerged as the animal model of choice, due to considerations of handling and costs and, importantly, due to the availability of...

Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine

Allergy (Oct 2012)

Atopic dermatitis (AD) is a paradigmatic inflammatory chronic skin disease. As for other chronic skin diseases, (i) the spectrum of the clinical phenotype and severity as well as (ii) the genetic background and (iii) the underlying mechanisms strongly suggest a high degree of pathophysiological heterogeneity yet...

IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization

Allergy (Oct 2012)

Background: There are no available clinical tests that can accurately predict peanut allergy (PA) and/or anaphylaxis. This study is aimed at evaluating whether the component-resolved diagnostic (CRD) IgE and IgG4 tests can (i) distinguish PA from asymptomatic peanut sensitization (PS) and (ii) differentiate...

An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE

Allergy (Oct 2012)

Background: Analyses of the molecular basis underlying allergenicity and allergen cross-reactivity, as well as improvement of allergy diagnostics and therapeutics, are hampered by the lack of human monoclonal IgE antibodies and knowledge about their epitopes. Here, we addressed the consecutive generation and epitope...

Short-term venom immunotherapy induces desensitization of FcεRI-mediated basophil response

Allergy (Oct 2012)

Background: The precise immunological mechanisms for the early clinical protection of venom immunotherapy (VIT) have not yet been explained. Our aim was to evaluate whether high-affinity IgE receptor (FcεRI) and the related basophil function have a role in the induction of short-term VIT protection. Methods: We...

Do mast cells link obesity and asthma?

Allergy (Oct 2012)

Asthma is a chronic inflammatory disease of the lungs. Both the number of cases and severity of asthma have been increasing without a clear explanation. Recent evidence suggests that obesity, which has also been increasing alarmingly, may worsen or precipitate asthma, but there is little evidence of how obesity may...

Protein tyrosine phosphatase SHP2 regulates TGF-β1 production in airway epithelia and asthmatic airway remodeling in mice

Allergy (Oct 2012)

Background: Transforming growth factor (TGF)-β1 produced in airway epithelia has been suggested as a contributor to the airway remodeling observed in asthma patients. The protein tyrosine phosphatase SHP2 is a demonstrable modulator of TGF-β1 production and thus a potential regulator of airway remodeling. Objectives:...

Systemic contact dermatitis to corticosteroids

Allergy (Oct 2012)

Background: Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic...

Microarray evaluation of specific IgE to allergen components in elite athletes

Allergy (Oct 2012)

Background: Allergic sensitization and diseases have been reported to have a very high and increasing prevalence in elite athletes. Over 80% of allergic athletes are poly-sensitized. Objective: This study aims at evaluating the potential diagnostic added value of a microarray technology (ImmunoCAP ISAC, Phadia AB [at...

Systemic contact dermatitis to corticosteroids

Allergy (Oct 2012)

Background: Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. Although the skin is the main sensitization and elicitation route, other routes, amongst them systemic...

Microarray evaluation of specific IgE to allergen components in elite athletes

Allergy (Oct 2012)

Background: Allergic sensitization and diseases have been reported to have a very high and increasing prevalence in elite athletes. Over 80% of allergic athletes are poly-sensitized. Objective: This study aims at evaluating the potential diagnostic added value of a microarray technology (ImmunoCAP ISAC, Phadia AB [at...

Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema

Allergy (Sep 2012)

Background: Hereditary angioedema is a rare autosomal dominant disease, and its correlation between genotype and phenotype seems not to exist. So far, there are very few studies on Chinese population. We aimed to establish a Chinese genetic database of hereditary angioedema and investigated the potential correlation...

Environmental bacteria and childhood asthma

Allergy (Sep 2012)

Background: We have previously found an inverse association of bacterial diversity with childhood asthma. It remains unclear whether certain bacteria account for the protective effect. Methods: The high variability of the bacterial 16S rRNA gene allows assessing diversity and specificity of bacterial communities by...

Validation of the modified allergic rhinitis and its impact on asthma (ARIA) severity classification in allergic rhinitis children: the PEDRIAL study

Allergy (Sep 2012)

Background: A modified allergic rhinitis and its impact on asthma (ARIA) (m-ARIA) criterion to classify the severity of allergic rhinitis (AR) has recently been validated in both treated and untreated adult patients; however, such information in children is lacking. The aim of this study was to validate this m-ARIA...

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment

Alzheimer's & Dementia: The Journal of the Alzheimer's Association (Feb 2013)

Background: Current hypothetical models of Alzheimer's disease (AD) pathogenesis emphasize the role of β-amyloid (Aβ), tau deposition, and neurodegenerative changes in the mesial temporal lobe, particularly the entorhinal cortex and hippocampus. However, many individuals with clinical AD who come to autopsy also...

Focal hemosiderin deposits and β-amyloid load in the ADNI cohort

Alzheimer's & Dementia: The Journal of the Alzheimer's Association (Feb 2013)

Background: Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD). Methods: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111),...

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF

Alzheimer's & Dementia: The Journal of the Alzheimer's Association (Feb 2013)

Background: Soluble oligomers of amyloid ß-protein (Aß) have been increasingly linked to synaptic dysfunction, tau alteration, and neuritic dystrophy in Alzheimer's disease (AD) and mouse models. There is a great need for assays that quantify Aß oligomers with high specificity and sensitivity. Methods: We designed and...

Diagnostic accuracy of markers for prodromal Alzheimer's disease in independent clinical series

Alzheimer's & Dementia: The Journal of the Alzheimer's Association (Feb 2013)

Objective: To capitalize on data from different clinical series to compare sensitivity and specificity of individual biomarkers for predicting mild cognitive impairment (MCI) progression to Alzheimer's disease (AD). Methods: Medial temporal atrophy, cortical hypometabolism, and cerebrospinal fluid biomarkers were...

AD dementia risk in late MCI, in early MCI, and in subjective memory impairment

Alzheimer's & Dementia: The Journal of the Alzheimer's Association (Feb 2013)

Objective: To compare the risk of developing Alzheimer’s disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance. Methods: The baseline sample (n = 2892) of the prospective cohort study in nondemented individuals (German Study...

Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging

Alzheimer's & Dementia: The Journal of the Alzheimer's Association (Feb 2013)

Objective: To evaluate the performance characteristics of florbetapir F18 positron emission tomography (PET) in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy control subjects (HCs). Methods: Florbetapir PET was acquired in 184 subjects (45 AD patients, 60 MCI patients, and 79 HCs)...

Improving dementia care: The role of screening and detection of cognitive impairment

Alzheimer's & Dementia: The Journal of the Alzheimer's Association (Feb 2013)

The value of screening for cognitive impairment, including dementia and Alzheimer's disease, has been debated for decades. Recent research on causes of and treatments for cognitive impairment has converged to challenge previous thinking about screening for cognitive impairment. Consequently, changes have occurred in...

American Heart Journal

EPITOME–2: An open–label study assessing the transition to a new formulation of intravenous epoprostenol in patients with pulmonary arterial hypertension

American Heart Journal (Oct 2013)

Background:

Continuous infusion of epoprostenol is the treatment of choice in patients with pulmonary arterial hypertension in functional classes III to IV. However, this treatment's limitations include instability at room temperature. A new epoprostenol formulation offers improved storage conditions and...

Two formulations of epoprostenol sodium in the treatment of pulmonary arterial hypertension: EPITOME–1 (epoprostenol for injection in pulmonary arterial hypertension), a phase IV, open–label, randomized study

American Heart Journal (Oct 2013)

Background:

Epoprostenol sodium with arginine–mannitol excipients (epoprostenol AM; Veletri [Actelion Pharmaceuticals Ltd, Allschwil, Switzerland]) and epoprostenol sodium with glycine–mannitol excipients (epoprostenol GM; Flolan [GlaxoSmithKline, Triangle Park, NC]) are intravenous treatments for...

American Journal of Cardiology

Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatment Study (HATS), Armed Forces Regression Study (AFREGS), and Carotid Plaque Composition by MRI During Lipid-lowering (CPC) Study

American Journal of Cardiology (Nov 2012)

Although the effect of niacin on the glucose levels in subjects with diabetes mellitus has been investigated, niacin’s effects on the glucose levels and atherosclerosis in subjects with normal glucose levels have not been well established. We examined the effect of niacin on the glucose levels, coronary stenosis...

Desmin Mutations and Arrhythmogenic Right Ventricular Cardiomyopathy

American Journal of Cardiology (Nov 2012)

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease characterized by fibrofatty replacement of the myocardium and ventricular arrhythmias, associated with mutations in the desmosomal genes. Only a missense mutation in the DES gene coding for desmin, the intermediate filament...

Cardiovascular Risk Assessment of Pulmonary Embolism With the GRACE Risk Score

American Journal of Cardiology (Nov 2012)

Despite the existence of several risk scores, the accurate prediction of the prognosis in pulmonary embolism (PE) remains a challenge. The Global Registry of Acute Coronary Events (GRACE) risk score has a high diagnostic performance for adverse outcomes in acute coronary syndrome. We aimed to assess the applicability...

Refining the Role of Antiplatelet Therapy in Medically Managed Patients With Acute Coronary Syndrome

American Journal of Cardiology (Nov 2012)

Dual-antiplatelet therapy with aspirin plus a P2Y12 receptor inhibitor is recommended for use as first-line therapy in patients with acute coronary syndromes (ACS) who undergo high-risk percutaneous coronary intervention. However, revascularization may not be a beneficial option for some subgroups of patients with ACS....

Relation of Morbid Obesity and Female Gender to Risk of Procedural Complications in Patients Undergoing Atrial Fibrillation Ablation

American Journal of Cardiology (Nov 2012)

Obese patients with atrial fibrillation (AF) are frequently treated with AF ablation. We sought to examine whether a body mass index (BMI) threshold exists beyond which the odds of experiencing a complication from AF ablation increases. All patients enrolled in the Vanderbilt AF Registry who underwent catheter-based AF...

Influence of Gender on Ischemic Times and Outcomes After ST-Elevation Myocardial Infarction

American Journal of Cardiology (Nov 2012)

Previous studies investigating the influence of gender on ST-segment elevation myocardial infarction have reported conflicting results. The aim of this study was to assess the influence of gender on ischemic times and outcomes after ST-segment elevation myocardial infarction in patients treated with primary...

Temporal Trends in Medical Therapies for ST- and Non-ST Elevation Myocardial Infarction: (from the Atherosclerosis Risk in Communities [ARIC] Surveillance Study)

American Journal of Cardiology (Nov 2012)

Reports from large studies using administrative data sets and event registries have characterized recent temporal trends and treatment patterns for acute myocardial infarction. However, few were population based, and fewer examined differences in patterns of treatment for patients presenting with ST-segment elevation...

Real Incidence of Diabetes Mellitus in a Coronary Disease Population

American Journal of Cardiology (Nov 2012)

The high prevalence of unknown diabetes mellitus (DM) in patients with coronary disease and that the oral glucose tolerance test (OGTT) is the best diagnostic method in this context are well known. However, data about the incidence of DM in this population have not been well described. In the present study, we sought...

Comparison of Surgical Septal Myectomy to Medical Therapy Alone in Patients With Hypertrophic Cardiomyopathy and Syncope

American Journal of Cardiology (Nov 2012)

The presence of syncope despite medical therapy in patients with hypertrophic cardiomyopathy (HC) is considered an indication for surgical myectomy; however, no study has examined the long-term effects on recurrent syncope and survival after surgery in these patients. We examined 239 patients with HC and a history of...

Relation of Vitamin D and Parathyroid Hormone to Cardiac Biomarkers and to Left Ventricular Mass (from the Cardiovascular Health Study)

American Journal of Cardiology (Nov 2012)

Vitamin D and parathyroid hormone (PTH) may affect cardiovascular health in patients with kidney disease and in the general population. The aim of this study was to investigate associations of serum 25-hydroxyvitamin D (25(OH)D) and PTH concentrations with a comprehensive set of biochemical, electrocardiographic, and...

Indexes of von Willebrand Factor as Biomarkers of Aortic Stenosis Severity (from the Biomarkers of Aortic Stenosis Severity [BASS] Study)

American Journal of Cardiology (Nov 2012)

We correlated von Willebrand factor (VWF) activity indexes and brain natriuretic peptide (BNP) with measures of aortic stenosis (AS) severity, bleeding, symptoms, and freedom from death or aortic valve replacement. Patients with AS (n = 66 [16 mild, 20 moderate, and 30 severe]) and aortic valve replacement (n = 21)...

American Journal of Kidney Diseases

CKD Stage at Nephrology Referral and Factors Influencing the Risks of ESRD and Death

American Journal of Kidney Diseases (Jan 2014)

Background:

Patients with chronic kidney disease (CKD) stages 3–5 are at increased risk of progressing to end–stage renal disease (ESRD) or dying prior to the development of ESRD compared with patients with less severe CKD. The magnitude of these risks may vary by stage, which has important...

Alkaline Phosphatase: A Possible Treatment for Sepsis–Associated Acute Kidney Injury in Critically Ill Patients

American Journal of Kidney Diseases (Jan 2014)

Acute kidney injury (AKI) is a common disease in the intensive care unit and accounts for high morbidity and mortality. Sepsis, the predominant cause of AKI in this setting, involves a complex pathogenesis in which renal inflammation and hypoxia are believed to play an important role. A new therapy should be aimed...

Removal of Dabigatran by Hemodialysis

American Journal of Kidney Diseases (Dec 2012)

Dabigatran is a newly available oral direct thrombin inhibitor approved for anticoagulation therapy to prevent strokes in patients with nonvalvular atrial fibrillation. Unlike warfarin, dabigatran's observed therapeutic window and minimal drug-to-drug interaction suggest that invasive laboratory testing and dose...

MicroRNAs in Kidney Disease: An Emerging Understanding

American Journal of Kidney Diseases (Dec 2012)

MicroRNAs (miRNAs) are short noncoding RNA molecules that function by negatively regulating the expression of their target genes in a tightly controlled manner. Accumulating evidence, based in part on effects seen after miRNA overexpression and/or knockdown, points to the critical involvement of miRNAs in kidney...

Effect of a High-Protein Diet on Kidney Function in Healthy Adults: Results From the OmniHeart Trial

American Journal of Kidney Diseases (Dec 2012)

Background: Consumption of a diet high in protein can cause glomerular hyperfiltration, a potentially maladaptive response, which may accelerate the progression of kidney disease. Study Design: An ancillary study of the OmniHeart trial, a randomized 3-period crossover feeding trial testing the effects of partial...

Association Between Abnormal Myocardial Fatty Acid Metabolism and Cardiac-Derived Death Among Patients Undergoing Hemodialysis: Results From a Cohort Study in Japan

American Journal of Kidney Diseases (Dec 2012)

Background: Detecting myocardial ischemia in hemodialysis patients is crucial given the high incidence of silent ischemia and the high cardiovascular mortality rates. Abnormal myocardial fatty acid metabolism as determined by imaging with 123I-labeled BMIPP (β-methyl iodophenyl-pentadecanoic acid) might be associated...

Retinopathy and Cognitive Impairment in Adults With CKD

American Journal of Kidney Diseases (Dec 2012)

Background10:30 Retinal microvascular abnormalities have been associated with cognitive impairment, possibly serving as a marker of cerebral small-vessel disease. This relationship has not been evaluated in persons with chronic kidney disease (CKD), a condition associated with increased risk of both retinal pathology...

Evaluation of Hypomagnesemia: Lessons From Disorders of Tubular Transport

American Journal of Kidney Diseases (Dec 2012)

Hypomagnesemia is a highly prevalent clinical condition affecting a large number of hospitalized patients. A decrease in systemic magnesium concentration may lead to impaired function of both neurologic and cardiovascular systems. The kidney has a pivotal role in magnesium handling by adjusting the urinary excretion of...

IgG4-Related Tubulointerstitial Nephritis With Plasma Cell–Rich Renal Arteritis

American Journal of Kidney Diseases (Dec 2012)

Immunoglobulin G4 (IgG4)-related tubulointerstitial nephritis is a newly recognized clinicopathologic entity that may occur as an isolated renal lesion or as part of a multisystem disorder. It is characterized by plasma cell–rich interstitial nephritis with abundant IgG4-positive plasma cells and IgG-dominant...

Renal Cortical Infarction Following Treatment With Sumatriptan in a Kidney Allograft Recipient

American Journal of Kidney Diseases (Dec 2012)

Renal cortical infarction is a rare cause of acute kidney injury that results from inadequate blood flow to the kidney, most commonly as a consequence of thrombotic or embolic occlusion of the renal artery or profound hypoperfusion. We report the case of a 78-year-old female kidney transplant recipient who developed a...

Induction and Maintenance Treatment of Proliferative Lupus Nephritis: A Meta-Analysis of Randomized Controlled Trials

American Journal of Kidney Diseases (Nov 2012)

Background: Lupus nephritis accounts for ∼1% of patients starting dialysis therapy. Treatment regimens combining cyclophosphamide with steroids preserve kidney function but have significant side effects. Newer immunosuppressive agents may have improved toxicity profiles. Study Design: Systematic review and...

The Perspectives of Adults Living With Peritoneal Dialysis: Thematic Synthesis of Qualitative Studies

American Journal of Kidney Diseases (Nov 2012)

Background: Most patients with end-stage renal disease require dialysis to survive because they are unable to access kidney transplantation. Peritoneal dialysis (PD) is recommended by some clinical practice guidelines as the dialysis treatment of choice for adults without significant comorbid conditions or those with...

Estimating the Total Incidence of Kidney Failure in Australia Including Individuals Who Are Not Treated by Dialysis or Transplantation

American Journal of Kidney Diseases (Nov 2012)

Background: To date, incidence data for kidney failure in Australia have been available for only those who start renal replacement therapy (RRT). Information about the total incidence of kidney failure, including non–RRT-treated cases, is important to help understand the burden of kidney failure in the community and...

Anuric Acute Kidney Injury in Neurofibromatosis 1

American Journal of Kidney Diseases (Nov 2012)

Neurofibromatosis is one of several genetic disorders characterized by hyperpigmented skin spots (café au lait spots) and multiple neurofibromas. It was first reported by Friedrich Daniel von Recklinghausen in 1882. There are 2 types of neurofibromatosis described in the literature: von Recklinghausen disease, or...

Hemodialysis Access Usage Patterns in the Incident Dialysis Year and Associated Catheter-Related Complications

American Journal of Kidney Diseases (Nov 2012)

Background: Hemodialysis (HD) access is considered a critical and actionable determinant of morbidity, with a growing literature suggesting that initial HD access type is an important marker of long-term outcomes. Accordingly, we examined HD access during the incident dialysis period, focusing on infection risk and...

Hemoglobin Stability in Patients With Anemia, CKD, and Type 2 Diabetes: An Analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) Placebo Arm

American Journal of Kidney Diseases (Nov 2012)

Background: Sparse data are available about the natural history of hemoglobin (Hb) level trends in contemporary patients with anemia, chronic kidney disease (CKD), and type 2 diabetes mellitus. We intended to describe Hb level trends over time with no or minimal administration of erythropoiesis-stimulating agents....

Pulmonary Hypertension in CKD

American Journal of Kidney Diseases (Nov 2012)

Pulmonary arterial hypertension is a rare disease often associated with positive antinuclear antibody and high mortality. Pulmonary hypertension, which rarely is severe, occurs frequently in patients with chronic kidney disease (CKD). The prevalence of pulmonary hypertension ranges from 9%-39% in individuals with stage...

Abdominal Compartment Syndrome and Acute Kidney Injury Due to Excessive Auto–Positive End-Expiratory Pressure

American Journal of Kidney Diseases (Nov 2012)

Abdominal compartment syndrome is an under-recognized cause of acute kidney injury in critically ill patients. We report a case of a patient with severe obstructive lung disease who, while intubated for respiratory failure, developed abdominal compartment syndrome and oliguric acute kidney injury due to air-trapping...

Effect of Early Initiation of Dialysis on Cardiac Structure and Function: Results From the Echo Substudy of the IDEAL Trial

American Journal of Kidney Diseases (Nov 2012)

Background: Abnormalities of cardiac structure and function are common in patients undergoing dialysis, and cardiovascular disease is the major cause of mortality in this group. Heart failure is a common clinical manifestation of cardiovascular disease and is preceded by left ventricular hypertrophy (LVH). There are...

Effects of Sodium Intake and Diet on Racial Differences in Urinary Potassium Excretion: Results From the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial

American Journal of Kidney Diseases (Nov 2012)

Background: We previously showed that African Americans excreted less urinary potassium than whites, even while consuming similar diets in the Dietary Approaches to Stop Hypertension (DASH) trial. We hypothesized that a low-sodium diet may eliminate these differences. Study Design: Data from the DASH-Sodium randomized...

ANCA-Associated Glomerulonephritis in Systemic-Onset Juvenile Idiopathic Arthritis

American Journal of Kidney Diseases (Dec 2011)

Systemic-onset juvenile idiopathic arthritis is an inflammatory disease of unknown cause and is not commonly associated with kidney involvement. We describe 3 patients with systemic-onset juvenile idiopathic arthritis with high disease activity who developed antineutrophil cytoplasmic antibody (ANCA)-associated...

Managing Older Adults With CKD: Individualized Versus Disease-Based Approaches

American Journal of Kidney Diseases (Dec 2011)

The last decade has seen the evolution and ongoing refinement of a disease-oriented approach to chronic kidney disease (CKD). Disease-oriented models of care assume a direct causal association between observed signs and symptoms and underlying disease pathophysiologic processes. Treatment plans target underlying...

American Journal of Ophthalmology

Effect of Cornea Donor Graft Thickness on the Outcome of Descemet Stripping Automated Endothelial Keratoplasty Surgery

American Journal of Ophthalmology (Sep 2013)

Purpose:

To determine whether Descemet stripping automated endothelial keratoplasty (DSAEK) donor cornea graft thickness impacts measurements of best spectacle-corrected visual acuity (BSCVA), refractive error and intraocular pressure (IOP).

Design:

Retrospective chart review in a tertiary care...

Effects of Choroidal Vascular Hyperpermeability on Anti–Vascular Endothelial Growth Factor Treatment for Polypoidal Choroidal Vasculopathy

American Journal of Ophthalmology (Sep 2013)

Purpose:

To evaluate the effect of choroidal vascular hyperpermeability, as determined using indocyanine green angiography (ICGA), on the outcome of anti–vascular endothelial growth factor (VEGF) treatment for polypoidal choroidal vasculopathy (PCV).

Design:

Retrospective comparative...

Peripapillary Choroidal Thickness in Both Eyes of Glaucoma Patients With Unilateral Visual Field Loss

American Journal of Ophthalmology (Sep 2013)

Purpose:

To investigate whether peripapillary choroidal thickness in perimetrically affected eyes of primary open-angle glaucoma (POAG) patients differs from that in perimetrically unaffected fellow eyes and eyes of healthy controls.

Design:

Retrospective, comparative, cross-sectional...

Photodynamic Therapy Versus Combination Therapy in Polypoidal Choroidal Vasculopathy: Changes of Aqueous Vascular Endothelial Growth Factor

American Journal of Ophthalmology (May 2013)

Purpose: To investigate the influence of photodynamic therapy (PDT) and combination of PDT and ranibizumab on aqueous humor levels of vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV). Design: Prospective randomized clinical trial. Method: We included 20 eyes with treatment-naïve PCV...

Subfoveal Fibrosis in Eyes With Neovascular Age-Related Macular Degeneration Treated With Intravitreal Ranibizumab

American Journal of Ophthalmology (May 2013)

Purpose: To assess baseline and follow-up characteristics of choroidal neovascularization (CNV) lesions in age-related macular degeneration in relation to the development of subfoveal subretinal fibrosis. Design: Retrospective, observational case series. Methods: settings and study population: One hundred ninety-seven...

Accuracy and Speed of Electronic Health Record Versus Paper-Based Ophthalmic Documentation Strategies

American Journal of Ophthalmology (May 2013)

Purpose: To compare accuracy and speed of keyboard and mouse electronic health record (EHR) documentation strategies with those of a paper documentation strategy. Design: Prospective cohort study. Methods: Three documentation strategies were developed: (1) keyboard EHR, (2) mouse EHR, and (3) paper. Ophthalmology...

Assessment of Retinal Function Before and After Idiopathic Macular Hole Surgery

American Journal of Ophthalmology (May 2013)

Purpose: To evaluate preoperative and postoperative retinal function in patients who underwent macular surgery for idiopathic macular hole. Design: Prospective, comparative, interventional case series. Methods: Thirty eyes of 30 patients with idiopathic macular hole were included in the study. Patients underwent pars...

Short-Term Outcomes of Aflibercept for Neovascular Age-Related Macular Degeneration in Eyes Previously Treated With Other Vascular Endothelial Growth Factor Inhibitors

American Journal of Ophthalmology (May 2013)

Purpose: To report results of aflibercept therapy in eyes with neovascular age-related macular degeneration previously treated with bevacizumab, ranibizumab, or both. Design: Retrospective, interventional, noncomparative, consecutive case series. Methods: Ninety-six eyes from 85 patients with neovascular age-related...

Correction of Ocular Shape in Retinal Optical Coherence Tomography and Effect on Current Clinical Measures

American Journal of Ophthalmology (May 2013)

Purpose: To address the misrepresentation of the eye in retinal optical coherence tomography (OCT) images and to examine the effect of this misrepresentation on retinal thickness measurements. Design: Prospective case series. Methods: Five subjects with recent orbital magnetic resonance imaging (MRI) scans and normal...

Correction of Lower Lid Retraction Using TarSys Bioengineered Grafts for Graves Ophthalmopathy

American Journal of Ophthalmology (May 2013)

Purpose: To investigate the efficacy of decellularized porcine-derived membrane (tarSys; IOP Inc), a bioengineered eyelid spacer graft, for lower lid retraction correction in patients with Graves ophthalmopathy. Design: Retrospective observational case series study. Methods: This was a retrospective review of patients...

American Journal of Otolaryngology

Malignant head and neck paragangliomas: Treatment efficacy and prognostic indicators

American Journal of Otolaryngology (May 2013)

Purpose: Malignant head and neck paragangliomas (MHNPs) are rare and occur in 6%–19% of all HNPs. We sought to identify predictors of survival and compare efficacy of treatment modalities to inform management of this rare disease. Materials and methods: We performed a retrospective cohort study of MHNP cases in the...

Variance of melatonin and cortisol rhythm in patients with allergic rhinitis

American Journal of Otolaryngology (May 2013)

Objectve: Allergic rhinitis is an IgE-mediated inflammatory disease which effects 10%–50% of the normal population. The mechanism of its formation and the circadian rhythm of cortisol and melatonin in allergic rhinitis have not been investigated. Study design: Salivary levels of melatonin and cortisol were measured by...

Otosclerosis and vitamin D receptor gene polymorphism

American Journal of Otolaryngology (May 2013)

Objective: The possible genetic relationship between otosclerosis and Vitamin D Receptor (VDR) gene polymorphism is uncertain. The aim of this study is to assess association between otosclerosis and VDR gene polymorphisms. Study Design: Case–control Studies. Setting: Tertiary referral center. Subjects and Methods:...

Salvage surgery of vestibular schwannoma after failed radiotherapy: The Gruppo Otologico experience and review of the literature

American Journal of Otolaryngology (Nov 2012)

Objectives: The use of radiation therapy has largely widespread and becomes in many centers the preference modality of treatment for symptomatic patients who are old, medically unfit for surgical therapy, those who refuse surgery and in some recurrent or residual growing tumors. The risk of radiotherapy failure in the...

Cognitive behaviour therapy for chronic subjective dizziness: longer-term gains and predictors of disability

American Journal of Otolaryngology (Nov 2012)

Purpose: The study sought to evaluate the longer-term effects of a brief cognitive behaviour therapy (CBT) intervention for patients with chronic subjective dizziness (CSD). In addition, it sought to identify predictors of longer-term disability in this group. Materials and methods: Forty-four patients with CSD...

Design and evaluation of tinnitus synthesis methods: From spectral to spatial matching

American Journal of Otolaryngology (Nov 2012)

Purpose: This study was designed to investigate methods to help patients suffering from unilateral tinnitus synthesizing an auditory replica of their tinnitus. Materials and methods: Two semi-automatic methods (A and B) derived from the auditory threshold of the patient and a method (C) combining a pure tone and a...

Contemporary management of pediatric lateral sinus thrombosis: A twenty year review

American Journal of Otolaryngology (Nov 2012)

Objectives: A case of pediatric otogenic lateral sinus thrombosis is reported, followed by a substantive literature review. Design: 104 patients were reviewed, culled from published case reports from 1993 to 2011 on the PubMed database. Methods: All full text case reports on the PubMed database from 1993 to 2011 with...

Management of neck metastases in T2N0 lip squamous cell carcinoma

American Journal of Otolaryngology (Nov 2012)

Background: Prophylactic neck dissection (PND) is indicated when the chance of occult lymph node metastases from head and neck tumors is significant. There is no consensus regarding which tumor size PND would be indicated in cases of lip cancer. Methods: A total of 139 patients with surgically treated lip cancer were...

Intramuscular hemangioma of the scalene musculature masquerading as a paraganglioma: A case series

American Journal of Otolaryngology (Nov 2012)

Intramuscular hemangiomas (IMHs) are uncommon benign vascular lesions, which develop in skeletal muscle. Herein, two cases of IMHs involving the cervical scalene musculature are presented. Such lesions are exceedingly rare, and can be difficult to distinguish from vagal paragangliomas based on clinical presentation,...

A case of necrotizing sialometaplasia involving bilateral parotid glands

American Journal of Otolaryngology (Nov 2012)

Necrotizing sialometaplasia of the parotid gland is infrequent and can be mistaken as a malignant disease. Its etiology is thought to be an insufficient blood supply. Bilateral involvement of this disease in parotid glands has been rarely reported in the English literature. We report a case of necrotizing...

American Journal of Otolaryngology - Head and Neck Medicine and Surgery

Bilateral secondary neurolymphomatosis of the internal auditory canal nerves: A case report

American Journal of Otolaryngology - Head and Neck Medicine and Surgery (May 2013)

Background: Neurolymphomatosis describes the malignant lymphomatous infiltration of nerves. Methods: We encountered a unique case of a 47-year-old patient with non-Hodgkin's lymphoma presenting with bilateral sensorineural hearing loss, vestibular dysfunction and bilateral facial nerve palsy. Results: Magnetic...

A case of congenital agenesis of the common carotid artery associated with an ectopic parathyroid adenoma mimicking a carotid body tumor

American Journal of Otolaryngology - Head and Neck Medicine and Surgery (May 2013)

Ectopic parathyroid adenomas can be encountered during four gland explorations, but nearly 80% of adenomas are localized with ultrasound and sestamibi imaging. Ectopic adenomas are thought to arise from abnormal migration during development. As a cervical congenital anomaly, common carotid artery agenesis is an...

Cupulolithiasis of the posterior semicircular canal

American Journal of Otolaryngology - Head and Neck Medicine and Surgery (Apr 2013)

Background: We sometimes experience patients with persistent torsional/vertical (upbeating) positional nystagmus in the head-hanging position. We have been convinced of the existence of cupulolithiasis of the posterior semicircular canal because such cases reveal persistent torsional/vertical (downbeating) positional...

American Journal of Reproductive Immunology

Fetal Sex–Based Differences in Maternal Hormones, Angiogenic Factors, and Immune Mediators During Pregnancy and the Postpartum Period

American Journal of Reproductive Immunology (Aug 2014)

Problem:

Several pregnancy complications have disparities based on the sex of the fetus. It is unknown whether the sex of the fetus differentially alters the maternal immune milieu, potentially contributing to the observed differences.

Method of study:

Using maternal plasma collected during 38...

Expression Profiles of Antimicrobial Peptides in the Genital Tract of Women Using Progesterone Intrauterine Devices Versus Combined Oral Contraceptives

American Journal of Reproductive Immunology (Aug 2014)

Problem:

Sex hormones can influence the immune defenses of the female genital tract (FGT) and its susceptibility to infections. Here we investigated the effect of different hormonal contraceptives on the production of antimicrobial peptides (AMPs) in different compartments of the female genital mucosa (FGM),...

American Journal of Transplantation

A Web-Based Application for Initial Screening of Living Kidney Donors: Development, Implementation and Evaluation

American Journal of Transplantation (Dec 2012)

Most centers utilize phone or written surveys to screen candidates who self-refer to be living kidney donors. To increase efficiency and reduce resource utilization, we developed a web-based application to screen kidney donor candidates. The aim of this study was to evaluate the use of this web-based application....

The Effect of Everolimus Versus Mycophenolate Upon Proteinuria Following Kidney Transplant and Relationship to Graft Outcomes

American Journal of Transplantation (Dec 2012)

Although mTOR inhibitor use has been associated with proteinuria in kidney transplant recipients, dose dependency and impact on allograft function are unknown. In a post hoc analysis, we compared rates of proteinuria 3 months posttransplant among everolimus (EVR) and mycophenolate (MPA) treatment arms and used a...

External Inosculation as a Feature of Revascularization Occurs After Free Transplantation of Murine Liver Grafts

American Journal of Transplantation (Dec 2012)

The induction of angiogenesis is essential for successful engraftment of freely transplanted cells or cellular composites. How to augment angiogenesis to ensure an appropriate viability of the grafts is still under investigation. This study evaluated the proangiogenic capability of different syngeneic free liver...

Late-Onset Cytomegalovirus (CMV) in Lung Transplant Recipients: Can CMV Serostatus Guide the Duration of Prophylaxis?

American Journal of Transplantation (Dec 2012)

Evidence supports the use of 12 months of cytomegalovirus prophylaxis in all at-risk lung transplants; whether cytomegalovirus serostatus can be used to further optimize this duration remains to be determined. The purpose of this retrospective study was to determine if cytomegalovirus serostatus of both donor and...

Anaesthesia

A prospective randomised controlled trial comparing tracheal intubation plus manual in–line stabilisation of the cervical spine using the Macintosh laryngoscope vs the McGrath® Series 5 videolaryngoscope

Anaesthesia (Aug 2014)

Cervical spine immobilisation can make direct laryngoscopy difficult, which might lead to airway complications. This randomised control trial compared the time to successful intubation using either the Macintosh laryngoscope or the McGrath® Series 5 videolaryngoscope in 128 patients who had cervical...

A nomogram for calculating the maximum dose of local anaesthetic

Anaesthesia (May 2014)

Toxic dose limits (mg.kg<sup>–1</sup>) for local anaesthetics based on body weight are well–established, but calculation of the maximum safe volume (ml) of a given agent and formulation is complex, and frequently results in errors. We therefore developed a nomogram to perform this calculation. We...

An analysis of patient safety incidents associated with medications reported from critical care units in the North West of England between 2009 and 2012

Anaesthesia (May 2014)

Incident reporting is promoted as a key tool for improving patient safety in healthcare. We analysed 2238 patient safety incidents involving medications submitted from up to 29 critical care units each year in the North West of England between 2009 and 2012; 452 (20%) of these incidents led to harm to patients....

The minimally invasive MitraClip procedure for mitral regurgitation under general anaesthesia: immediate effects on the pulmonary circulation and right ventricular function

Anaesthesia (May 2014)

A relatively new minimally invasive cardiological procedure, called the MitraClip<sup>™</sup>, does not require sternotomy and may have a number of advantages compared with open mitral valve surgery, but its acute impact on the pulmonary circulation and right ventricular function during general...

Evaluation of changes in tidal volume during mask ventilation following administration of neuromuscular blocking drugs

Anaesthesia (May 2014)

The practice of checking the ability to mask ventilate before administering neuromuscular blocking drugs remains controversial. We prospectively evaluated the changes in the expired tidal volume during pressure–controlled ventilation (two–handed mask ventilation technique) as a surrogate marker to assess...

Prevalence and implications of a difference in systolic blood pressure between one arm and the other in vascular surgical patients

Anaesthesia (Oct 2013)

Inter-arm differences in blood pressure may confound haemodynamic management in vascular surgery. We evaluated 898 patients in the vascular pre-assessment clinic to determine the prevalence of inter-arm differences in systolic and mean arterial pressure, quantify the consequent risk of clinical error in siting...

Influence of a modified propofol equilibration rate constant (ke0) on the effect-site concentration at loss and recovery of consciousness with the Marsh model

Anaesthesia (Sep 2013)

This study compared the predicted effect-site concentration of propofol at loss and recovery of consciousness when using target-controlled infusion devices with the same pharmacokinetic model (Marsh) but a different plasma effect-site equilibration rate constant (ke0), the Diprifusor™...

Management of arterial lines and blood sampling in intensive care: a threat to patient safety

Anaesthesia (Sep 2013)

In 2008, the UK National Patient Safety Agency (NPSA) made recommendations for safe arterial line management. Following a patient safety incident in our intensive care unit (ICU), we surveyed current practice in arterial line management and determined whether these recommendations had been adopted. We contacted all...

The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia

Anaesthesia (Aug 2013)

This randomised, controlled, double-blind study investigated the effects of intra-operative magnesium sulphate administration on the incidence of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia. Seventy children were randomly allocated to receive a 30 mg.kg−1...

Comparison of the Baska® mask with the single-use laryngeal mask airway in low-risk female patients undergoing ambulatory surgery

Anaesthesia (Jul 2013)

We compared the Baska® mask with the single-use classic laryngeal mask airway (cLMA) in 150 females at low risk for difficult tracheal intubation in a randomised, controlled clinical trial. We found that median (IQR [range]) seal pressure was significantly higher with the Baska mask compared with the...

Changes in cardiac index and blood pressure on positioning children prone for scoliosis surgery

Anaesthesia (May 2013)

In this prospective observational study we investigated the changes in cardiac index and mean arterial pressure in children when positioned prone for scoliosis correction surgery. Thirty children (ASA 1–2, aged 13–18 years) undergoing primary, idiopathic scoliosis repair were recruited. The cardiac index and mean...

Cardiopulmonary resuscitation in the pregnant patient: a manikin-based evaluation of methods for producing lateral tilt

Anaesthesia (May 2013)

The importance of minimising aortocaval compression during cardiopulmonary resuscitation in late pregnancy is widely accepted. Current European guidelines suggest employing manual displacement of the uterus with left lateral tilt to achieve this. Several methods for producing lateral tilt have been described; however,...

The immunomodulatory role of esmolol in patients undergoing laparoscopic gastrectomy due to gastric cancer

Anaesthesia (May 2013)

Esmolol has a beneficial effect on the T helper 1/T helper 2 balance in patients with heart failure. The aim of this study was to investigate the immunomodulatory role of esmolol during and after surgery. Patients undergoing laparoscopic gastrectomy due to gastric cancer were enrolled. Patients in the esmolol group (n...

Effect of epidural analgesia on change in Mallampati class during labour

Anaesthesia (May 2013)

Mallampati class has been shown to increase during labour. Epidural analgesia might influence this change. The aim of our study was to compare the change in Mallampati class during labour in parturients who did and did not receive epidural analgesia and study the association of these changes with pre-defined clinical...

Investigation of phthalate release from tracheal tubes

Anaesthesia (Dec 2012)

Phthalates are chemicals used extensively in the manufacture of plastics for their desirable physical characteristics. In addition to enhancing the performance of plastics, phthalates have a number of undesirable effects, principally endocrine disruptor effects, that may have adverse effects on reproductive development...

The effect of inner tube placement on resistance and work of breathing through tracheostomy tubes: a bench test

Anaesthesia (Dec 2012)

To reduce the risk of tracheostomy tube blockage, a removable inner tube can be used. However, this will reduce the size of the lumen and will increase airflow resistance and work of breathing. The magnitude of this increase in workload is unknown. We undertook a bench test to measure the effect. A lung model was...

A randomised comparison of variable-frequency automated mandatory boluses with a basal infusion for patient-controlled epidural analgesia during labour and delivery

Anaesthesia (Dec 2012)

This trial was conducted to compare the analgesic efficacy of administering variable-frequency automated boluses at a rate proportional to the patient's needs with fixed continuous basal infusion in patient-controlled epidural analgesia (PCEA) during labour and delivery. We recruited a total of 102 parturients in...

A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component

Anaesthesia (Dec 2012)

Persistent mechanical irritation of the nerve root sets up a series of events mediating sensitisation of the dorsal roots and dorsal horns in the spinal cord. Current evidence supports the role of magnesium in blocking central sensitisation through its effect on N-methyl–d-aspartate receptors. We studied the role of...

Effect of penehyclidine hydrochloride on the incidence of intra-operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia

Anaesthesia (Dec 2012)

Intra-operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double-blinded trial in 920 patients undergoing breast cancer surgery under bispectral index-guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on...

The effect of pre-procedure anxiety on sedative requirements for sedation during colonoscopy

Anaesthesia (Nov 2012)

This study investigated the effects of pre-procedural anxiety (assessed using the Beck Anxiety Inventory) on sedative requirements in 135 patients undergoing sedation for colonoscopy. Deep sedation was defined as loss of consciousness and no response to colonoscopy, and was achieved by target-controlled infusion of...

Patient-maintained propofol sedation using reaction time monitoring: a volunteer safety study

Anaesthesia (Nov 2012)

Previous volunteer studies of an effect-site controlled, patient-maintained sedation system using propofol have demonstrated a risk of over-sedation. We have incorporated a reaction-time monitor into the handset of the patient-maintained sedation system to add an individualised patient-feedback mechanism. This study...

The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia

Anaesthesia (Nov 2012)

Increasing the calculated plasma concentration of propofol has been shown to increase choice reaction time and visual and auditory response times. We studied the relationship of reaction to a vibrating handset as the effect-site target-controlled propofol concentration was incrementally increased in 20 patients during...

A randomised comparison of InnoScope and Macintosh laryngoscope in simulated difficult tracheal intubation in manikins

Anaesthesia (Nov 2012)

We conducted a crossover randomised study to evaluate the performance of a novel optical stylet, the InnoScope, for tracheal intubation in simulated normal and difficult airways. Twenty-five anaesthetists attempted tracheal intubation on a SimMan 3G simulator using the InnoScope first followed by the Macintosh...

The location of paravertebral catheters placed using the landmark technique

Anaesthesia (Nov 2012)

The aim of this prospective clinical study was to evaluate the location of paravertebral catheters that were placed using the classical landmark puncture technique and to correlate the distribution of contrast dye injected through the catheters with the extent of somatic block. Paravertebral catheter placement was...

Tracheal intubation with a camera embedded in the tube tip (Vivasight™)

Anaesthesia (Nov 2012)

We studied tracheal intubation in manikins and patients with a camera embedded in the tip of the tracheal tube (Vivasight™). Four people in two teams and two individuals attempted intubation of a manikin through an i-gel™ 10 times each. The tracheas of 12 patients with a Mallampati grade of 1 were intubated with a...

A comparison of clinical practice guidelines for proximal femoral fracture

Anaesthesia (Nov 2012)

Clinical practice guidelines are designed to assist clinical decision-making by summarising evidence and forming recommendations. The number of available guidelines is vast and they vary in relevance and quality. We reviewed guidelines relevant to the management of a patient with a fractured neck of femur and explored...

Peripartum outcomes and anaesthetic management of parturients with moderate to complex congenital heart disease or pulmonary hypertension*

Anaesthesia (Nov 2012)

We performed a retrospective cohort analysis of pregnancies among women with moderate to complex congenital heart disease or pulmonary hypertension over a 12-year period, resulting in a cohort of 107 cases in 65 women. Neuraxial analgesia or anaesthesia was provided in 84%, 89% and 95% of spontaneous vaginal, operative...

Arrhythmogenic risk of pulmonary artery catheterisation in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation

Anaesthesia (Nov 2012)

Many clinicians consider severe aortic stenosis to be a contraindication to pulmonary artery catheterisation, except during open heart surgery with cardiopulmonary bypass. This is due to the perceived high risk of arrhythmia, although the true incidence of ventricular tachycardia and fibrillation remains unclear. We...

The McGrath® Series 5 videolaryngoscope vs the Macintosh laryngoscope: a randomised, controlled trial in patients with a simulated difficult airway

Anaesthesia (Nov 2012)

We compared the McGrath® Series 5 videolaryngoscope with the Macintosh laryngoscope in a simulated difficult airway, using manual in-line stabilisation in 88 anaesthestised patients of ASA physical status 1-2. The primary outcome was laryngoscopic view. Secondary outcomes included rates of successful tracheal...

A review of enhanced recovery for thoracic anaesthesia and surgery

Anaesthesia (Nov 2012)

During the past decade, there has been a dramatic increase in the number of thoracic surgical procedures carried out in the UK. The current financial climate dictates that more efficient use of resources is necessary to meet escalating demands on healthcare. One potential means to achieve this is through the...

The association of pre-operative physical fitness and physical activity with outcome after scheduled major abdominal surgery

Anaesthesia (Nov 2012)

We studied whether reported physical activity and measurements of fitness (hand, leg and inspiration) were associated with postoperative in-hospital mortality, length of stay and discharge destination in 169 patients after major oncological abdominal surgery. In multivariate analysis, adequate activity level (OR 5.5,...

A randomised controlled trial of dexmedetomidine for suspension laryngoscopy

Anaesthesia (Oct 2012)

We randomly allocated 80 patients to intravenous dexmedetomidine (0.25, 0.5, or 1 μg.kg−1) or placebo 15 min before anaesthetic induction. Dexmedetomidine 0.5 and 1.0 μg.kg−1 significantly reduced the mean (95% CI) propofol effect-site concentrations by 0.83 (0.63–1.03) μg.ml−1, p = 0.001 and 1.29 (1.12–1.46) μg.ml−1,...

Comparison of peri-operative core temperature in obese and non-obese patients

Anaesthesia (Oct 2012)

Our aim was to compare peri-operative core temperatures and the incidence of hypothermia in obese and non-obese women with active forced-air warming. Twenty female patients scheduled for abdominal surgery were allocated to two groups according to body mass index. Ten obese (30.0–34.9 kg.m−2) and 10 non-obese (18.5–24.9...

Effect of table tilt on ligamentum flavum length measured using ultrasonography in pregnant women

Anaesthesia (Oct 2012)

The purpose of this study was to assess whether applying dorsal table tilt to a seated parturient positioned for neuraxial anaesthesia (i.e. facing laterally with her legs over the side of the table) increased the size of the target area for the neuraxial needle. We performed lumbar ultrasonography on 20 pregnant women...

Comparison of peri-operative core temperature in obese and non-obese patients

Anaesthesia (Oct 2012)

Our aim was to compare peri-operative core temperatures and the incidence of hypothermia in obese and non-obese women with active forced-air warming. Twenty female patients scheduled for abdominal surgery were allocated to two groups according to body mass index. Ten obese (30.0–34.9 kg.m−2) and 10 non-obese (18.5–24.9...

Evaluation of point-of-care haemoglobin measuring devices: a comparison of Radical-7™ pulse co-oximetry, HemoCue® and laboratory haemoglobin measurements in obstetric patients

Anaesthesia (Oct 2012)

We prospectively compared two point-of-care haemoglobin concentration measuring devices with laboratory measurements to determine their accuracy in women undergoing caesarean section delivery. The two devices were the Masimo Rainbow SET® Radical -7™ pulse co-oximeter and the HemoCue® HB 201+, which is a cuvette-type...

Effect of propofol on hypoxia re-oxygenation induced neuronal cell damage in vitro

Anaesthesia (Oct 2012)

Propofol may protect neuronal cells from hypoxia re-oxygenation injury, possibly via an antioxidant actions under hypoxic conditions. This study investigated the molecular effects of propofol on hypoxia-induced cell damage using a neuronal cell line. Cultured human IMR-32 cells were exposed to propofol (30 μm) and...

Comparison of the single-use Ambu® aScope™ 2 vs the conventional fibrescope for tracheal intubation in patients with cervical spine immobilisation by a semirigid collar

Anaesthesia (Oct 2012)

Fibreoptic intubation remains a key technique for the management of difficult intubation. We randomly compared the second generation single-use Ambu® aScope™ 2 videoscope with a standard re-usable flexible intubating fibrescope in 50 tracheal intubations in patients with a difficult airway simulated by a semirigid...

Assessment of block height for satisfactory spinal anaesthesia for caesarean section

Anaesthesia (Oct 2012)

We investigated block heights that anaesthetists considered adequate for caesarean section to proceed under spinal anaesthesia. During 3 months, 15 obstetric anaesthetists recorded block height to touch, pinprick or cold when spinal anaesthesia was considered satisfactory for caesarean section to proceed. Median (IQR...

Assessment of block height for satisfactory spinal anaesthesia for caesarean section

Anaesthesia (Oct 2012)

We investigated block heights that anaesthetists considered adequate for caesarean section to proceed under spinal anaesthesia. During 3 months, 15 obstetric anaesthetists recorded block height to touch, pinprick or cold when spinal anaesthesia was considered satisfactory for caesarean section to proceed. Median (IQR...

Modified patient-controlled remifentanil bolus delivery regimen for labour pain

Anaesthesia (Oct 2012)

To improve the analgesic efficiency and to simplify the administration of remifentanil for systemic analgesia in labour, we contrived a modified delivery regimen with a specific infusion profile and variable dosing and conducted a single-blind randomised crossover study to compare it with the previous ‘classical’...

The effect of intravenous lidocaine on laryngeal and respiratory reflex responses in anaesthetised children

Anaesthesia (Oct 2012)

We studied the effect of intravenous lidocaine on laryngeal and respiratory reflex responses in children anaesthetised with sevoflurane. We tested the hypothesis that the incidence of laryngospasm evoked by laryngeal stimulation is temporarily diminished after the administration of lidocaine. Forty children, aged...

Comparison of non-invasive and invasive blood pressure in aeromedical care

Anaesthesia (Oct 2012)

Blood pressure measurement is an essential physiological measurement for all critically ill patients. Previous work has shown that non-invasive blood pressure is not an accurate reflection of invasive blood pressure measurement. In a transport environment, the effects of motion and vibration may make non-invasive blood...

A meta-analysis of magnesium for tetanus

Anaesthesia (Oct 2012)

Uncontrolled studies suggest that magnesium sulphate controls spasms in patients with established tetanus. We performed a meta-analysis of controlled trials that compared magnesium sulphate with placebo or diazepam for the treatment of patients with tetanus. We searched PubMed, Scopus, Embase and the Cochrane clinical...

Comparison of non-invasive and invasive blood pressure in aeromedical care

Anaesthesia (Oct 2012)

Blood pressure measurement is an essential physiological measurement for all critically ill patients. Previous work has shown that non-invasive blood pressure is not an accurate reflection of invasive blood pressure measurement. In a transport environment, the effects of motion and vibration may make non-invasive blood...

Changes in the photoplethysmogram with tracheal intubation and remifentanil concentration

Anaesthesia (Sep 2012)

Autonomic sympathetic activation, for instance following noxious stimuli, decreases the size and flattens the shape of the photoplethysmographic peripheral pulse waveform. We report a simple measure of the waveform shape, the ratio of mean-to-peak wave amplitude, for measuring nociception level during general...

A randomised crossover trial comparing a single-use polyvinyl chloride laryngeal mask airway with a single-use silicone laryngeal mask airway

Anaesthesia (Sep 2012)

We compared insertion rates of single-use polyvinyl chloride laryngeal mask airways (LMAs) vs single-use silicone LMAs in 72 anaesthetised patients. Both airways were produced by Flexicare Medical. Laryngeal mask airway insertion was successful on the first attempt in 68/72 (94%) polyvinyl chloride LMAs vs 64/72 (89%)...

Closed-loop double-vasopressor automated system to treat hypotension during spinal anaesthesia for caesarean section: a preliminary study

Anaesthesia (Sep 2012)

Hypotension occurs in most caesarean sections under spinal anaesthesia, necessitating vasopressor administration. However, the optimal dosing regimen remains unclear. We have developed a novel vasopressor delivery system that automatically administers phenylephrine or ephedrine based on continuous non-invasive blood...

A comparison of the pelvic angle applied using lateral table tilt or a pelvic wedge at elective caesarean section

Anaesthesia (Sep 2012)

Lateral table tilt or a pelvic wedge are commonly used to reduce inferior vena cava compression during obstetric anaesthesia in the supine position. Direct measurement of pelvic angle allows individual assessment of the effectiveness of these manoeuvres in achieving a tilted position. We observed routine practice...

The impact on cardiac diagnosis and mortality of focused transthoracic echocardiography in hip fracture surgery patients with increased risk of cardiac disease: a retrospective cohort study

Anaesthesia (Sep 2012)

Hip fracture surgery is associated with a high rate of mortality and morbidity; heart disease is the leading cause and is often unrecognised and inadequately treated. Pre-operative focused transthoracic echocardiography by anaesthetists frequently influences management, but mortality outcome studies have not been...

A randomised comparison of two intranasal dexmedetomidine doses for premedication in children

Anaesthesia (Sep 2012)

We compared sedation levels in children following administration of intranasal dexmedetomidine. One hundred and sixteen children aged between 1 and 8 years were enrolled in this prospective, randomised trial. Children were assigned to receive either intranasal dexmedetomidine 1 μg.kg−1 (Group 1) or 2 μg.kg−1 (Group 2)....

A randomised comparison of two intranasal dexmedetomidine doses for premedication in children

Anaesthesia (Sep 2012)

We compared sedation levels in children following administration of intranasal dexmedetomidine. One hundred and sixteen children aged between 1 and 8 years were enrolled in this prospective, randomised trial. Children were assigned to receive either intranasal dexmedetomidine 1 μg.kg−1 (Group 1) or 2 μg.kg−1 (Group 2)....

The impact on cardiac diagnosis and mortality of focused transthoracic echocardiography in hip fracture surgery patients with increased risk of cardiac disease: a retrospective cohort study

Anaesthesia (Sep 2012)

Hip fracture surgery is associated with a high rate of mortality and morbidity; heart disease is the leading cause and is often unrecognised and inadequately treated. Pre-operative focused transthoracic echocardiography by anaesthetists frequently influences management, but mortality outcome studies have not been...

A comparison of intra-operative blood loss and acid–base balance between vasopressor and inotrope strategy during living donor liver transplantation: a randomised, controlled study

Anaesthesia (Sep 2012)

Administration of vasopressors or inotropes during liver transplant surgery is almost universal, as this procedure is often accompanied by massive haemorrhage, acid–base imbalance, and cardiovascular instability. However, the actual agents that should be used and the choice between a vasopressor and an inotrope...

A meta-analysis of the accuracy and precision of the ultrasonic cardiac output monitor (USCOM)

Anaesthesia (Aug 2012)

The ultrasonic cardiac output monitor is a non-invasive, continuous-wave Doppler monitor that can be used to measure cardiac output. Its accuracy and precision in peri-operative and critical care has been assessed with varied results. We conducted a meta-analysis to calculate a pooled mean bias, precision and...

A clinical evaluation of four non-Luer spinal needle and syringe systems

Anaesthesia (Aug 2012)

We performed an evaluation of non-Luer spinal devices supplied by four manufacturers or suppliers: Polymedic; Pajunk; Sarstedt; and Smiths. For each supplier, 100 evaluations were performed using a 25-G 90-mm spinal needle, 3-ml syringe, 5-ml syringe and filter needle; for comparison, 100 evaluations were performed...

The effect of beta-2 adrenergic receptor haplotype variations on the haemodynamic response following spinal anaesthesia for caesarean delivery

Anaesthesia (Aug 2012)

We investigated whether genetic variations of the beta-2 adrenergic receptor (ADRB2) modulate the haemodynamic response following spinal anaesthesia for caesarean delivery. We focused on the effects of haplotypes formed by combinations of the Arg16Gly and Gln27Glu polymorphisms. Clinical data from 143 healthy...

The effect of a cervical collar on the seal pressure of the LMA Supreme™: a prospective, crossover trial

Anaesthesia (Aug 2012)

For personnel inexperienced in airway management, supraglottic airway devices may be the first choice in an emergency. Changing head position is known to reduce the seal pressure of a laryngeal mask airway. The aim of this study was to investigate whether the use of a cervical collar improves the stability of airways...

A clinical evaluation of four non-Luer spinal needle and syringe systems

Anaesthesia (Aug 2012)

We performed an evaluation of non-Luer spinal devices supplied by four manufacturers or suppliers: Polymedic; Pajunk; Sarstedt; and Smiths. For each supplier, 100 evaluations were performed using a 25-G 90-mm spinal needle, 3-ml syringe, 5-ml syringe and filter needle; for comparison, 100 evaluations were performed...

The effect of beta-2 adrenergic receptor haplotype variations on the haemodynamic response following spinal anaesthesia for caesarean delivery

Anaesthesia (Aug 2012)

We investigated whether genetic variations of the beta-2 adrenergic receptor (ADRB2) modulate the haemodynamic response following spinal anaesthesia for caesarean delivery. We focused on the effects of haplotypes formed by combinations of the Arg16Gly and Gln27Glu polymorphisms. Clinical data from 143 healthy...

The effect of a cervical collar on the seal pressure of the LMA Supreme™: a prospective, crossover trial

Anaesthesia (Aug 2012)

For personnel inexperienced in airway management, supraglottic airway devices may be the first choice in an emergency. Changing head position is known to reduce the seal pressure of a laryngeal mask airway. The aim of this study was to investigate whether the use of a cervical collar improves the stability of airways...

Effect of hyperoxia and vascular occlusion on tissue oxygenation measured by near infra-red spectroscopy (InSpectra™): a volunteer study

Anaesthesia (Aug 2012)

Standard cardiorespiratory monitoring may fail to detect occult tissue ischaemia. This study assessed whether a near infra-red spectroscopy tissue oxygen saturation monitor (InSpectra™) could detect progressive peripheral tissue ischaemia and whether hyperoxia may confound tissue oxygen saturation measurement. Tissue...

Effect of hyperoxia and vascular occlusion on tissue oxygenation measured by near infra-red spectroscopy (InSpectra™): a volunteer study

Anaesthesia (Aug 2012)

Standard cardiorespiratory monitoring may fail to detect occult tissue ischaemia. This study assessed whether a near infra-red spectroscopy tissue oxygen saturation monitor (InSpectra™) could detect progressive peripheral tissue ischaemia and whether hyperoxia may confound tissue oxygen saturation measurement. Tissue...

Usability testing of a prototype Phone Oximeter with healthcare providers in high- and low-medical resource environments

Anaesthesia (Aug 2012)

To increase the use of pulse oximetry by capitalise on the wide availability of mobile phones, we have designed, developed and evaluated a prototype pulse oximeter interfaced to a mobile phone. Usability of this Phone Oximeter was tested as part of a rapid prototyping process. Phase 1 of the study (20 subjects) was...

Evaluation of the CEL-100 videolaryngoscopeTM for double-lumen tracheal tube insertion after failure using the Macintosh laryngoscope

Anaesthesia (Jul 2012)

We prospectively evaluated the CEL-100 videolaryngoscopeTM for insertion of double-lumen tracheal tubes in 48 consecutive patients who had been found to have an unanticipated Cormack and Lehane grade 3 (n = 43) and grade 4 (n = 5) laryngeal view and in whom two attempts at tracheal intubation using the Macintosh...

Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass

Anaesthesia (Jul 2012)

We conducted a study to assess pharmacokinetics of high-dose tranexamic acid for 24 h after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary bypass. High-dose tranexamic acid involved a bolus of 30 mg.kg−1 infused over 15 min followed by a 16 mg.kg−1.h−1 infusion until chest...

Effects of sugammadex and rocuronium mast cell number and degranulation in rat liver

Anaesthesia (Jul 2012)

We investigated the effect of rocuronium- and sugammadex-induced mast cell increase and degranulation in rat portal triads. Forty-two rats, in six groups, received either rocuronium 1 mg.kg−1; sugammadex 15 mg.kg−1; sugammadex 100 mg.kg−1; rocuronium 1 mg.kg−1 and 5 min later, sugammadex 15 mg.kg−1; rocuronium 1...

Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass

Anaesthesia (Jul 2012)

We conducted a study to assess pharmacokinetics of high-dose tranexamic acid for 24 h after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary bypass. High-dose tranexamic acid involved a bolus of 30 mg.kg−1 infused over 15 min followed by a 16 mg.kg−1.h−1 infusion until chest...

Evaluation of the CEL-100 videolaryngoscopeTM for double-lumen tracheal tube insertion after failure using the Macintosh laryngoscope

Anaesthesia (Jul 2012)

We prospectively evaluated the CEL-100 videolaryngoscopeTM for insertion of double-lumen tracheal tubes in 48 consecutive patients who had been found to have an unanticipated Cormack and Lehane grade 3 (n = 43) and grade 4 (n = 5) laryngeal view and in whom two attempts at tracheal intubation using the Macintosh...

The pre-emptive analgesic effect of a cyclooxygenase-2 inhibitor in a rat model of acute postoperative pain

Anaesthesia (Jul 2012)

We examined the pre-emptive analgesic effect of a cyclooxygenase (COX)-2 inhibitor in a rat surgical pain model and characterised the changes in cutaneous COX-2 around a surgical site. Thermal hyperalgesia and mechanical allodynia were tested in the rats for three days after incision and skin tissues were collected for...

A multicentre observational study of intra-operative ventilatory management during general anaesthesia: tidal volumes and relation to body weight

Anaesthesia (Jul 2012)

We conducted an observational prospective multicenter study to describe the practices of mechanical ventilation, to determine the incidence of use of large intra-operative tidal volumes (≥ 10 ml.kg−1 of ideal body weight) and to identify patient factors associated with this practice. Of the 2960 patients studied in 97...

Platelet mapping as part of modified thromboelastography (TEG®) in patients undergoing cardiac surgery and cardiopulmonary bypass

Anaesthesia (Jul 2012)

The platelet-mapping assay of the thromboelastograph was used to measure platelet aggregation and to examine the effect of cardiopulmonary bypass on multiple platelet receptors and the role of altered receptor activity in postoperative bleeding. The percentage platelet aggregation for collagen, adenosine diphosphate...

An evaluation of the ability of leucocyte depletion filters to remove components of amniotic fluid

Anaesthesia (Jul 2012)

Haemorrhage remains an important cause of maternal mortality worldwide. Cell salvage carries a theoretical risk of amniotic fluid embolus syndrome and is too expensive for use in many parts of the world. To explore cheaper options, we investigated whether a leucocyte depletion filter alone removes components of pure...

Epidural catheter connectors: a laboratory-based comparison of the Portex Tuohy-Borst and EpiFuse™ designs

Anaesthesia (Jul 2012)

Disconnection of an epidural catheter from its connector may result in patient harm and commonly requires resiting of the epidural. Clamp-connector designs such as the novel Portex EpiFuse™ potentially offer an improved safety profile over screw-cap designs such as the Tuohy-Borst, but comparative studies are limited....

A national service evaluation of the impact of alcohol on admissions to Scottish intensive care units

Anaesthesia (Jul 2012)

Alcohol-related disease adversely affects the outcome of critically ill patients. The burden of this in Scotland is higher than elsewhere in the United Kingdom. In a prospective observational study of all patients admitted to the 24 intensive care units in Scotland we assessed the proportion of admissions in which...

Evaluation of radial and ulnar blood flow after radial artery cannulation with 20- and 22-gauge cannulae using duplex Doppler ultrasound

Anaesthesia (Jul 2012)

This study evaluated ulnar and radial artery blood flow after radial artery cannulation during general anaesthesia using Doppler ultrasound. A total of 80 patients were randomly assigned to receive radial artery cannulation with either a 20-G or 22-G cannula. Arterial diameter, peak systolic velocity, end-diastolic...

Modulation of pain sensation by stress-related testosterone and cortisol

Anaesthesia (Jul 2012)

Stress increases cortisol and decreases testosterone. It is not known whether pain is affected by stress-related testosterone. Therefore, we investigated whether stress can affect pain perception by decreasing testosterone and increasing cortisol. Pain thresholds, pain and anxiety ratings and salivary testosterone and...

The effect of the European Working Time Directive on anaesthetic working patterns and training

Anaesthesia (Jul 2012)

There is concern that the European Working Time Directive 2009 has led to reduced time available for training, and this study examined if this has been the case. For two identical six-month periods in 1999 (pre-Directive) and 2009 (post-Directive), weekly data were collected on the total number of sessions attended by...

A national service evaluation of the impact of alcohol on admissions to Scottish intensive care units

Anaesthesia (Jul 2012)

Alcohol-related disease adversely affects the outcome of critically ill patients. The burden of this in Scotland is higher than elsewhere in the United Kingdom. In a prospective observational study of all patients admitted to the 24 intensive care units in Scotland we assessed the proportion of admissions in which...

The effect of the European Working Time Directive on anaesthetic working patterns and training

Anaesthesia (Jul 2012)

There is concern that the European Working Time Directive 2009 has led to reduced time available for training, and this study examined if this has been the case. For two identical six-month periods in 1999 (pre-Directive) and 2009 (post-Directive), weekly data were collected on the total number of sessions attended by...

Modulation of pain sensation by stress-related testosterone and cortisol

Anaesthesia (Jul 2012)

Stress increases cortisol and decreases testosterone. It is not known whether pain is affected by stress-related testosterone. Therefore, we investigated whether stress can affect pain perception by decreasing testosterone and increasing cortisol. Pain thresholds, pain and anxiety ratings and salivary testosterone and...

Epidural catheter connectors: a laboratory-based comparison of the Portex Tuohy-Borst and EpiFuse™ designs

Anaesthesia (Jul 2012)

Disconnection of an epidural catheter from its connector may result in patient harm and commonly requires resiting of the epidural. Clamp-connector designs such as the novel Portex EpiFuse™ potentially offer an improved safety profile over screw-cap designs such as the Tuohy-Borst, but comparative studies are limited....

Evaluation of radial and ulnar blood flow after radial artery cannulation with 20- and 22-gauge cannulae using duplex Doppler ultrasound

Anaesthesia (Jul 2012)

This study evaluated ulnar and radial artery blood flow after radial artery cannulation during general anaesthesia using Doppler ultrasound. A total of 80 patients were randomly assigned to receive radial artery cannulation with either a 20-G or 22-G cannula. Arterial diameter, peak systolic velocity, end-diastolic...

A randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery

Anaesthesia (Jul 2012)

Deep neuromuscular blockade during certain surgical procedures may improve operating conditions. Sugammadex can be used to reverse deep neuromuscular blockade without waiting for spontaneous recovery. This randomised study compared recovery times from neuromuscular blockade induced by rocuronium 0.6 mg.kg−1, using...

A meta-analysis of prevention of postoperative nausea and vomiting: randomised controlled trials by Fujii et al. compared with other authors

Anaesthesia (Jun 2012)

The population sampling in randomised controlled trials by Fujii et al. have been shown to exhibit unusual distributions. This systematic review analysed the effectiveness of prophylactic antiemetics in trials by Fujii et al. compared with other authors. Granisetron was more effective in trials by Fujii et al.,...

Quantitative analysis of changes in blood concentrations and ‘presumed effect-site concentration’ of sevoflurane during one-lung ventilation

Anaesthesia (Jun 2012)

During one-lung ventilation, ventilation-perfusion mismatch decreases the arterial concentration of inhaled anaesthetics due to the arterial-to-venous concentration difference. This study tested the hypothesis that in humans, the ‘presumed effect-site concentration’ (taken as the mid-point between the arterial and...

Haemodynamics in women with untreated pre-eclampsia

Anaesthesia (Jun 2012)

This study aimed to compare the haemodynamics in healthy pregnant women with the haemodynamics in women with untreated pre-eclampsia, to determine the cardiovascular reason for hypertension in pre-eclampsia. 40 women with untreated pre-eclampsia, 40 matched healthy pregnant women and 20 non-pregnant women were studied...

Haemodynamics in women with untreated pre-eclampsia

Anaesthesia (Jun 2012)

This study aimed to compare the haemodynamics in healthy pregnant women with the haemodynamics in women with untreated pre-eclampsia, to determine the cardiovascular reason for hypertension in pre-eclampsia. 40 women with untreated pre-eclampsia, 40 matched healthy pregnant women and 20 non-pregnant women were studied...

A multicentre observational study of intra-operative ventilatory management during general anaesthesia: tidal volumes and relation to body weight

Anaesthesia (Jun 2012)

We conducted an observational prospective multicenter study to describe the practices of mechanical ventilation, to determine the incidence of use of large intra-operative tidal volumes (≥ 10 ml.kg−1 of ideal body weight) and to identify patient factors associated with this practice. Of the 2960 patients studied in 97...

A randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery

Anaesthesia (Jun 2012)

Deep neuromuscular blockade during certain surgical procedures may improve operating conditions. Sugammadex can be used to reverse deep neuromuscular blockade without waiting for spontaneous recovery. This randomised study compared recovery times from neuromuscular blockade induced by rocuronium 0.6 mg.kg−1, using...

A randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery

Anaesthesia (Jun 2012)

Deep neuromuscular blockade during certain surgical procedures may improve operating conditions. Sugammadex can be used to reverse deep neuromuscular blockade without waiting for spontaneous recovery. This randomised study compared recovery times from neuromuscular blockade induced by rocuronium 0.6 mg.kg−1, using...

A randomised controlled trial comparing two insertion techniques for the Laryngeal Mask Airway Flexible™ in patients undergoing dental surgery

Anaesthesia (Jun 2012)

The Laryngeal Mask Airway FlexibleTM (LMA Flexible) has been widely utilised for dental, ophthalmology and otorhinolaryngology-related procedures. Our study evaluates two different techniques of inserting the LMA Flexible for patients undergoing day-case dental surgery. One hundred and eight patients were randomly...

A new technique for percutaneous dilatational tracheostomy (G-Trach): preliminary experience in pigs

Anaesthesia (Jun 2012)

Tracheostomies are currently used for airway management in patients requiring long-term respiratory assistance. The dilatational percutaneous technique of forming tracheostomies is a valuable alternative to traditional surgical ‘open’ techniques. In this study, we tested a new dilatational percutaneous tracheostomy...

A randomised comparison of the self-pressurised air-QTM intubating laryngeal airway with the LMA UniqueTM in children*

Anaesthesia (Jun 2012)

We conducted a randomised trial comparing the self-pressurised air-QTM intubating laryngeal airway (air-Q SP) with the LMA-Unique in 60 children undergoing surgery. Outcomes measured were airway leak pressure, ease and time for insertion, fibreoptic examination, incidence of gastric insufflation and complications....

Comparison of Macintosh and AirtraqTM laryngoscopes in obese patients placed in the ramped position

Anaesthesia (Jun 2012)

This study compared intubation conditions produced by the Macintosh and AirtraqTM laryngoscopes when used in obese patients in the ramped position. One hundred and thirty-two patients having bariatric surgery were placed in the ramped position and randomly assigned to have their tracheas intubated using either the...

Effect of positioning from supine and left lateral positions to left lateral tilt on maternal blood flow velocities and waveforms in full-term parturients

Anaesthesia (May 2012)

Positioning the parturient from supine to the left lateral tilt position (supine-to-tilt) may not effectively displace the gravid uterus, but turning from the left lateral position to the left lateral tilt position (left lateral-to-tilt) may keep the gravid uterus displaced and prevent aortocaval compression. Fifty-one...

Anaphylaxis admissions to UK critical care units between 2005 and 2009

Anaesthesia (May 2012)

Anaphylaxis is a life-threatening emergency that may necessitate admission to a critical care unit. There are no reports of the frequency of admission to critical care units for patients with anaphylaxis or indeed any description of their demographic characteristics or outcomes. We analysed all physician-diagnosed...

Removal of the stylet from the tracheal tube: effect of lubrication

Anaesthesia (May 2012)

We compared the work needed to retract a non-lubricated and a lubricated stylet from a tracheal tube over 24 h. Stylets were lubricated with sterile water, silicone fluid, lidocaine spray, lidocaine gel, MedPro® lubricating gel or Lacri-Lube®. The mean (SD) work in joules needed to retract the stylet by 5 cm from the...

Utility of Nociceptive Flexion Reflex Threshold, Bispectral Index, Composite Variability Index and Noxious Stimulation Response Index as measures for nociception during general anaesthesia

Anaesthesia (May 2012)

Movement and haemodynamic responses to noxious stimuli during general anaesthesia are regarded as signs of nociception. We compared the Nociceptive Flexion Reflex Threshold (NFRT), Bispectral Index (BIS), Composite Variability Index (CVI), Noxious Stimulation Response Index (NSRI) and the calculated...

Extended release formulations for local anaesthetic agents

Anaesthesia (May 2012)

Systemic toxicity through overdose of local anaesthetic agents is a real concern. By encapsulating local anaesthetics in biodegradable carriers to produce a system for prolonged release, their duration of action can be extended. This encapsulation should also improve the safety profile of the local anaesthetic as it is...

Use of the pre-operative shuttle walk test to predict morbidity and mortality after elective major colorectal surgery

Anaesthesia (May 2012)

High-risk surgery is performed in every acute hospital. These patients often have increased peri-operative risk related to their poor cardiorespiratory reserve. Formal risk assessment is recommended for such patients; cardiopulmonary exercise testing is a well established triage tool, but is unavailable in many...

Fluid balance monitoring by cuff-occluded rate of rise of peripheral venous pressure in haemodialysis patients

Anaesthesia (May 2012)

Cuff-occluded rate of rise of peripheral venous pressure has been proposed to reflect volume changes in experimental studies. The aim of this study was to evaluate changes in cuff-occluded rate of rise of peripheral venous pressure associated with fluid removal by haemodialysis in six adult patients with chronic renal...

Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®)*

Anaesthesia (Apr 2012)

We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate...

Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m)

Anaesthesia (Apr 2012)

We present a randomised, controlled, crossover trial of the Caudwell Xtreme Everest (CXE) closed circuit breathing system vs an open circuit and ambient air control in six healthy, hypoxic volunteers at rest and exercise at Everest Base Camp, at 5300 m. Compared with control, arterial oxygen saturations were improved...

Is ‘starting on time’ useful (or useless) as a surrogate measure for ‘surgical theatre efficiency’?

Anaesthesia (Apr 2012)

We analysed more than 7000 theatre lists from two similar UK hospitals, to assess whether start times and finish times were correlated. We also analysed gap times (the time between patients when no anaesthesia or surgery occurs), to see whether these affected theatre efficiency. Operating list start and finish times...

Novice performance of ultrasound-guided needle advancement: standard 38-mm transducer vs 25-mm hockey stick transducer

Anaesthesia (Apr 2012)

The optimal method to develop expertise in ultrasound-guided regional anaesthesia is unknown. Studies of laryngoscopic expertise in novices demonstrate that the choice of laryngoscope affects performance. In this study, we aimed to compare the effect of two different linear array transducers (38-mm standard vs 25-mm...

Evaluation of a new analyser for rapid measurement of blood propofol concentration during cardiac surgery

Anaesthesia (Apr 2012)

We report laboratory and clinical evaluations of a blood propofol concentration analyser. Laboratory experiments used volunteer blood spiked with known propofol concentrations over the clinically relevant concentrations from 0.5 to 16 μg.ml−1 to assess linearity and the influence of haematocrit and concurrent drug...

A comparison of the Pentax Airway Scope™ with the Airtraq™ in an infant manikin

Anaesthesia (Apr 2012)

We compared the Pentax Airway ScopeTM with the AirtraqTM optical laryngoscope in an infant manikin. Twenty-three anaesthetists randomly performed tracheal intubation: at rest, (a) with the Airway Scope and (b) with the Airtraq; and during chest compressions, (c) with the Airway Scope and (d) with the Airtraq. The...

Anaesthesia and Intensive Care Medicine

Fluid balance and non-respiratory functions of the lung

Anaesthesia and Intensive Care Medicine (Dec 2011)

The primary function of the lung is gas exchange between alveolar gas and the blood flowing through the nearby capillaries. This stage of gas exchange takes place by diffusion. Because gases such as oxygen diffuse relatively slowly through liquids it is essential that the fluid barrier is kept as short as possible....

Andrology

Detection and quantification of human herpes viruses types 4–6 in sperm samples of patients with fertility disorders and chronic inflammatory urogenital tract diseases

Andrology (Jun 2014)

Acute and chronic infections of the seminal tract are among the most common causes of male infertility. As at least half of male infertility cases are classified as idiopathic, some of these cases might be attributed to asymptomatic infection. The detection and quantification of Epstein–Barr virus (EBV),...

Erectile dysfunction in heart failure patients: a critical reappraisal

Andrology (Jan 2013)

Heart failure (HF) is a complex clinical syndrome with a constantly increasing incidence and prevalence in western countries. Total absence of sexual activity is registered in 30% of HF patients. Moreover, HF-induced reduction in exercise tolerance, side effects of HF medications and the coexistence of shared risk...

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Andrology (Jan 2013)

Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and...

Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse

Andrology (Jan 2013)

The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8−/− mice lacking Sox9 in Sertoli cells fail to form testis cords and cannot establish spermatogenesis. Although genetic and histological data show an important...

A guanidinylated bioreducible polymer as a novel gene carrier to the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction

Andrology (Jan 2013)

A prerequisite for the successful clinical application of gene therapy in erectile dysfunction (ED) is the availability of safe and efficient gene delivery systems. The aim of this study was to examine the effectiveness of guanidinylated bioreducible polymer (GBP) polyplexes for gene delivery systems, which take...

Sexual intercourse with leucocytospermic men may be a possible booster of oxidative stress in female partners of infertile couples

Andrology (Jan 2013)

Human semen has undoubtedly significant influence on the organism of the female counterpart. At the same time there are no studies in English literature investigating the influence of sexual intercourse on oxidative stress level in women's organism. Seventeen infertile couples where male partners were with (n = 5) or...

On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid

Andrology (Jan 2013)

Oxidative stress is known to have a major impact on human sperm function and, as a result, there is a need to develop sensitive methods for measuring reactive oxygen species (ROS) generation by these cells. A variety of techniques have been developed for this purpose including chemiluminescence (luminol and lucigenin),...

Posthumous sperm utilization in men presenting for sperm banking: an analysis of patient choice

Andrology (Jan 2013)

The question remains as to whether or not men would agree to posthumous sperm use for pregnancy initiation. Often, these individuals' lives are suddenly interrupted and prior consent is rarely given. Therefore, post-mortem retrieval or use of these spermatozoa remains controversial and the incidence of consent for...

Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders

Andrology (Jan 2013)

Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whether...

Sperm counts may have declined in young university students in Southern Spain

Andrology (Jan 2013)

Several studies have investigated temporal trends in semen quality in Northern Europe, but none has examined this question in Southern Europe. A prior study conducted in Almeria Province (Southern Spain) reported higher sperm count and concentration among Spanish young men recruited from 2001 to 2002 compared with...

High variability in results of semen analysis in Andrology Laboratories in Tuscany (Italy): the experience of an external quality control (EQC) programme

Andrology (Jan 2013)

We report the results of the first three trials of an external quality control (EQC) programme performed in 71 laboratories executing semen analysis in Tuscany Region (Italy). At the end of the second trial, participants were invited to attend a teaching course illustrating and inviting to adhere to procedures...

A randomized, double-blind, crossover, placebo-controlled comparative clinical trial of arginine aspartate plus adenosine monophosphate for the intermittent treatment of male erectile dysfunction

Andrology (Dec 2012)

Efficacy and safety of l-arginine aspartate 8 g combined with 200 mg of adenosine monophosphate (AA) with placebo (PL) alone for intermittent treatment of mild-to-moderate erectile dysfunction (ED) were compared. The study design was a double-blind, PL-controlled, two-way crossover randomized clinical trial with 26...

Anesthesia and Analgesia

Perioperative Assessment of Diastolic Dysfunction

Anesthesia and Analgesia (Aug 2011)

Assessment of diastolic function should be a component of a comprehensive perioperative transesophageal echocardiographic examination. Abnormal diastolic function exists in > 50% of patients presenting for cardiac and high-risk noncardiac surgery, and has been shown to be an independent predictor of adverse...

An Intraoperative Small Dose of Ketamine Prevents Remifentanil-Induced Postanesthetic Shivering

Anesthesia and Analgesia (Aug 2011)

Patients undergoing gynecological laparotomy were randomized to receive either 0.5 mg/kg ketamine at induction of anesthesia followed by an infusion of 0.3 mg/kg/h until the end of surgery (ketamine group, n = 32), or an equivalent volume of normal saline (control group, n = 32). Anesthesia was maintained with IV...

An Exploration of Remifentanil-Propofol Combinations That Lead to a Loss of Response to Esophageal Instrumentation, a Loss of Responsiveness, and/or Onset of Intolerable Ventilatory Depression

Anesthesia and Analgesia (Mar 2011)

Background: Remifentanil and propofol are increasingly used for short-duration procedures in spontaneously breathing patients. In this setting, it is preferable to block the response to moderate stimuli while avoiding loss of responsiveness (LOR) and intolerable ventilatory depression (IVD). In this study, we explored...

Annals of Allergy, Asthma & Immunology

Childhood asthma and obesity—what is the true link?

Annals of Allergy, Asthma & Immunology (Aug 2014)

Obesity rates have increased significantly in children in many parts of the world, especially in North America.1 According to data from the most recent National Health and Nutrition Examination Survey, approximately 17% (or 12.5 million) of US children and adolescents 2 to 9 years old are...

Health–related quality of life in food–allergic adults from eight European countries

Annals of Allergy, Asthma & Immunology (May 2014)

Background:

Food allergy can impair health–related quality of life (HRQL). Food Allergy Quality of Life Questionnaires (FAQLQs) have been developed and validated, including an adult form (FAQLQ–AF). HRQL has not, to date, been measured across different European countries using a uniform...

Changing roles of eosinophils in health and disease

Annals of Allergy, Asthma & Immunology (May 2014)

Objective:

To review and highlight the unappreciated roles of eosinophils suggested by recent studies.

Data Sources:

The literature, unpublished observations, and insights by the authors.

Study Selections:

Basic studies of mouse models and patient–based clinical studies of...

Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium

Annals of Allergy, Asthma & Immunology (Nov 2012)

Background: Air pollution from road traffic is a serious public health problem. Epidemiologic studies have demonstrated adverse health effects associated with environmental pollution. Diesel exhaust is a major contributor to ambient particulate matter air pollution. We studied the effects of exposure to diesel exhaust...

The identification of potentially pathogenic and therapeutic epitopes from common human allergens

Annals of Allergy, Asthma & Immunology (Nov 2012)

Objectives: To outline the processes involved in large-scale T-cell epitope identification from common allergens and illustrate their relevance to development of allergy specific immunotherapy. Data Sources: A set of studies recently published by our laboratory illustrating high-throughput identification of allergen...

Atopic dermatitis in a high-risk cohort: natural history, associated allergic outcomes, and risk factors

Annals of Allergy, Asthma & Immunology (Nov 2012)

Background: Atopic dermatitis (AD) is commonly associated with asthma and other atopic disorders in childhood. Objective: To evaluate the natural history of AD and its association with other allergic outcomes in a high-risk cohort through the age of 7 years. Methods: A total of 373 high-risk infants, who had undergone...

Population-based study on association between birth weight and risk of asthma: A propensity score approach

Annals of Allergy, Asthma & Immunology (Nov 2012)

Background: Previous studies that assessed the role of birth weight in the risk of asthma have been limited because of selection bias and covariate imbalance. Objective: To assess the association between birth weight and risk of asthma by applying a propensity score approach. Methods: The study was designed as a...

Significance of Ara h 2 in clinical reactivity and effect of cooking methods on allergenicity

Annals of Allergy, Asthma & Immunology (Nov 2012)

Background: The prevalence and clinical severity of peanut allergy vary between Western countries and Asia. It has been suggested that cooking methods are responsible for this discrepancy. Objectives: To evaluate the specific IgE responses to major peanut allergens in peanut allergic Korean children and to examine the...

Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Anaphylaxis to egg or severe egg allergy has been considered a contraindication to receiving trivalent seasonal influenza vaccine (TIV). Objective: To evaluate the safety of TIV among severely egg allergic children. Methods: A 2-phase, multicenter study at 7 sites was conducted between October 2010 and...

Sensitivity of impulse oscillometry and spirometry in beta-blocker induced bronchoconstriction and beta-agonist bronchodilatation in asthma

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Impulse oscillometry (IOS) provides an alternative method of assessing pulmonary function to conventional spirometry. Objective: To compare the sensitivities of IOS and spirometry in assessing bronchoconstriction to propranolol and bronchodilation with salbutamol. Methods: A post-hoc analysis of a...

The prevalence and characteristics of food allergy in urban minority children

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Urban minority children are known to have high rates of asthma and allergic rhinitis, but little is known about food allergy in this population. Objective: To examine the prevalence and characteristics of food allergy in an urban pediatric population. Methods: A retrospective review of electronic medical...

Inappropriate home albuterol use during an acute asthma exacerbation

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Increased asthma morbidity and mortality is associated with inappropriate home self-management skills. Objectives: To examine the proportion of children presenting to the emergency department (ED) with an acute asthma exacerbation with incorrect home use of their albuterol inhaler and to identify factors...

Efficacy of venom immunotherapy given every 3 or 4 months: a prospective comparison with the conventional regimen

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Standard venom immunotherapy involves the administration of the maintenance dose every 4 to 6 weeks. This regimen may have adherence problems, especially in the long term; thus, extended intervals have been proposed. Objective: We prospectively compared the efficacy of 3- or 4-month extended maintenance...

Clarifying the transmission route of Staphylococcus aureus colonizing the skin in early childhood atopic dermatitis

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: We previously found that skin-colonizing Staphylococcus aureus in early childhood atopic dermatitis (AD) originates predominantly from the patient's nose, whereas maternal transmission did not contribute substantially to colonization. Objective: To investigate the transmission route and definitive source of...

Evaluation and validation of a bee venom sting challenge performed by a micro-syringe

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: The honeybee sting challenge is considered a reliable procedure to evaluate the efficacy of specific immunotherapy, but it is difficult and unpractical to perform in clinical practice, because live insects are required. Objective: To assess the feasibility and reliability of a challenge test using a...

Effect of oral administration with pravastatin and atorvastatin on airway hyperresponsiveness and allergic reactions in asthmatic mice

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Asthma is characterized by airway hyperresponsiveness and remodeling. Pravastatin and atorvastatin are used clinically as cholesterol-lowering agents but also exhibit anti-inflammatory and immunomodulating properties. Objective: To investigate the therapeutic effect of oral statins on airway...

Correlation of Der p 2 T-cell responses with clinical characteristics of children allergic to house dust mite

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: An understanding of the mechanisms responsible for the development and maintenance of allergic inflammation and their clinical implications is needed to develop specific and successful treatment for allergy. Objectives: To characterize in vitro T-cell responses to Der p 2, one of the major allergens of...

Dichlorophenol-containing pesticides and allergies: results from the US National Health and Nutrition Examination Survey 2005-2006

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Epidemiologic studies support the hypothesis that reduced microbial exposure in westernized societies promotes atopy. Dichlorophenols are widely used as pesticides and for chlorination of water. They have a strong bactericidal effect that could affect microflora in the environment. However, it is unknown...

Short-acting β-agonist use and its ability to predict future asthma-related outcomes

Annals of Allergy, Asthma & Immunology (Oct 2012)

Background: Short-acting β-agonist (SABA) use is well established in predicting asthma events in adults. However, this predictive ability has yet to be established in a pediatric population together with an assessment of amount of use. Objective: To identify the number of SABA canisters that best predicts future...

Early interventional treatment with intranasal corticosteroids compared with postonset treatment in pollinosis

Annals of Allergy, Asthma & Immunology (Sep 2012)

Background: The usefulness of early interventional treatment (EIT) with intranasal corticosteroids (INSs) compared with postonset treatment (POT) has not been clarified. Objectives: To study the efficacy and safety of EIT with INSs compared with POT and placebo in Japanese cedar/cypress pollinosis. Methods: We designed...

Neonatal vitamin D status and childhood peanut allergy: a pilot study

Annals of Allergy, Asthma & Immunology (Sep 2012)

Background: Although a number of factors have been proposed to explain the increase in food allergy during the last decade, the possibility that vitamin D status may play a pathogenic role has received recent attention. Objective: To determine whether lower levels of neonatal 25-hydroxyvitamin D (25[OH]D) would be...

Is Methacholine Challenge Sufficient to Rule out Bronchial Hyperresponsiveness in Patients with Suspected Asthma?

Annals of Allergy, Asthma & Immunology (Dec 2011)

Bronchial provocation challenges may be useful for establishing a definitive diagnosis of asthma in individuals with compatible symptoms and normal pulmonary function test results....

Successful C1 Inhibitor Prophylaxis During Zenker Diverticulum Repair in a Patient with Hereditary Angioedema

Annals of Allergy, Asthma & Immunology (Dec 2011)

Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by C1 inhibitor protein deficiency characterized by recurrent episodes of angioedema of the skin, laryngeal edema, or abdominal…...

Annals of Emergency Medicine

Critical Care Management of Verapamil and Diltiazem Overdose With a Focus on Vasopressors: A 25-Year Experience at a Single Center

Annals of Emergency Medicine (May 2013)

Study objective: Verapamil or diltiazem overdose can cause severe morbidity and death, and there exist limited human data describing management and outcome of a large number of such patients. This article describes the management and outcome of patients with nondihydropyridine calcium-channel blocker overdose, with an...

A Multicenter Study of the Risk of Intra-Abdominal Injury in Children After Normal Abdominal Computed Tomography Scan Results in the Emergency Department

Annals of Emergency Medicine (Apr 2013)

Study objective: We determine whether intra-abdominal injury is rarely diagnosed after a normal abdominal computed tomography (CT) scan result in a large, generalizable sample of children evaluated in the emergency department (ED) after blunt torso trauma. Methods: This was a planned analysis of data collected during a...

Poor Sensitivity of a Modified Alvarado Score in Adults With Suspected Appendicitis

Annals of Emergency Medicine (Apr 2013)

Study objective: A clinical decision rule that identifies patients at low risk for appendicitis may reduce the reliance on computed tomography (CT) for diagnosis. We seek to prospectively evaluate the accuracy of a low modified Alvarado score in emergency department (ED) patients with suspected appendicitis and compare...

Diagnostic Accuracy of Pulmonary Embolism Rule-Out Criteria: A Systematic Review and Meta-analysis

Annals of Emergency Medicine (Dec 2011)

Study objective:To perform a systematic review and meta-analysis to define the diagnostic performance of pulmonary embolism rule-out criteria (PERC) in deferring the need for D-dimer testing to rule out pulmonary embolism in the emergency department (ED). Methods: We searched EMBASE, MEDLINE, Scopus, Web of Knowledge,...

Annals of Oncology

A comparison of carboplatin and paclitaxel with cisplatinum and 5–fluorouracil in definitive chemoradiation in esophageal cancer patients

Annals of Oncology (Feb 2014)

Background:

In esophageal cancer (EC) patients who are not eligible for surgery, definitive chemoradiation (dCRT) with curative intent using cisplatinum with 5–fluorouracil (5–FU) is the standard chemotherapy regimen. Nowadays carboplatin/paclitaxel is also often used. In this study, we compared...

Late referrals to home palliative care service affecting death at home in advanced cancer patients in Japan: a nationwide survey

Annals of Oncology (Feb 2011)

Background: To identify factors influencing place of death among home palliative care patients with advanced cancer, focusing on the timing of referrals from hospital to home care settings. Methods: A cross-sectional nationwide questionnaire survey was conducted on home palliative care patients at 1000 randomly...

Annals of the Rheumatic Diseases

EULAR recommendations for vaccination in paediatric patients with rheumatic diseases

Annals of the Rheumatic Diseases (Aug 2011)

Evidence-based recommendations for vaccination of paediatric patients with rheumatic diseases (PaedRD) were developed by following the EULAR standardised procedures for guideline development. The EULAR task force consisted of (paediatric) rheumatologists/immunologists, one expert in vaccine evaluation, one expert in...

Annals of Vascular Surgery

Breast Cancer and Venous Disease: A Retrospective Cohort Study

Annals of Vascular Surgery (Jun 2013)

Background:

Breast cancer (BC) and chronic venous disease (CVD) are in some way related to hormonal effects, and often the clinical manifestations of CVD intersect with the clinical course of BC. This article describes the correlations between these clinical conditions.

Methods:

A total of 1138...

Patterns and Management of Blunt Abdominal Aortic Injury

Annals of Vascular Surgery (Jun 2013)

Background:

Blunt abdominal aortic injury (BAAI) is historically associated with significant morbidity and mortality. Our institutional experience was analyzed to define current patterns of injury and to help guide management.

Methods:

Adult patients with BAAI between January 2000 and July 2011...

Review of the Management of Blunt Thoracic Aortic Injuries According to Current Treatment Recommendations

Annals of Vascular Surgery (Jun 2013)

Background:

Blunt thoracic aortic injury (BTAI) is associated with high mortality. Recent Society for Vascular Surgery (SVS) guidelines recommend repair of all but SVS grade I injuries. This study's objective was to retrospectively determine guideline adherence at the authors' trauma center, and its impact on...

Endovascular Management of Severe Bleeding After Major Abdominal Surgery

Annals of Vascular Surgery (Jun 2013)

Background:

In this study we analyzed embolization and stent–graft results.

Methods:

Demographics, indications, procedures, and outcomes of patients treated with embolization or stent grafting for late postoperative bleeding after major abdominal surgery were retrospectively recorded....

A Practical Index to Predict 30-day Mortality After Major Amputation

Annals of Vascular Surgery (Jun 2013)

Background:

Patients at risk of mortality after amputation have not been well identified. We sought to devise a clinical index predicting 30–day mortality after amputation that would allow stratification of intensity of postoperative care.

Methods:

The National Surgical Quality Improvement...

Approaches to the Management of Spontaneous Isolated Visceral Artery Dissection

Annals of Vascular Surgery (Jun 2013)

Background:

Spontaneous isolated celiac and superior mesenteric artery dissection without aortic dissection is a rare disease. Recently, an increasing number of cases have been diagnosed and the prognosis has improved significantly because of technical progress in computed tomography (CT). However, management...

Open Conversion After Endovascular Aortic Aneurysm Repair: A Single-Center Experience

Annals of Vascular Surgery (Jun 2013)

Background:

The endovascular treatment of an abdominal aortic aneurysm (AAA) is a treatment with low risk and good reported results. This retrospective study analyzed experience with patients requiring surgical conversion after endovascular abdominal aortic aneurysm repair (EVAR).

Methods:

A total...

Clinical and Subclinical Varicocele Incidence in Patients with Primary Varicose Veins Requiring Surgery

Annals of Vascular Surgery (Jun 2013)

Background:

The purpose of this study was to analyze the incidence of clinical and subclinical varicocele in patients with primary varicose veins requiring surgery.

Methods:

A total of 100 patients with primary varicose veins requiring surgery were evaluated. Clinical varicocele was found in each...

Safety and Efficacy of Carotid Endarterectomy in Octogenarians

Annals of Vascular Surgery (Jun 2013)

Background:

To evaluate the outcome of carotid endarterectomy (CEA) in octogenarians.

Method:

Between January 2005 and July 2010, all CEA patients were prospectively recorded. Patients were categorized into those <80 and ≥80 years of age. Primary outcome measures were hospital duration of stay...

Endovascular Treatment of Thoracic Aortic Aneurysm: A Single-Center Experience

Annals of Vascular Surgery (Jun 2013)

Background:

We assess the effectiveness of thoracic endovascular aortic repair (TEVAR) in patients with thoracic artery aneurysm with a retrospective analysis of our experience and a review of the literature.

Methods:

Between January 2005 and December 2011, 53 patients with thoracic aortic aneurysm...

New Cerebral Ischemic Lesions After Carotid Endarterectomy

Annals of Vascular Surgery (Jun 2013)

Background:

We sought to investigate the incidence and location of new cerebral ischemic lesions after carotid endarterectomy (CEA) using diffusion-weighted magnetic resonance imaging (DW-MRI).

Methods:

Sixty-six consecutive patients (50 males with a mean [±SD] age of 69 ± 9 years) who underwent...

Thoracic Endovascular Aortic Repair with Visceral Arteries Intermittent Clamp Technique for Descending Thoracic Aortic Aneurysm with Shaggy Aorta

Annals of Vascular Surgery (Jun 2013)

Aortic repair for severely atheromatous aneurysm remains a challenge. We used an intermittent clamp technique for all visceral arteries during thoracic endovascular aortic repair (TEVAR) for a thoracic aortic aneurysm with a “shaggy aorta” to prevent systemic thromboembolism. In addition, we applied an...

Annuals of Rheumatic Diseases

Do non-steroidal anti-inflammatory drugs have a significant effect on detection and grading of ultrasound-detected synovitis in patients with rheumatoid arthritis? Results from a randomised study

Annuals of Rheumatic Diseases (Jul 2011)

Objectives: To determine whether non-steroidal anti-inflammatory drugs (NSAIDs) have a significant effect on ultrasonographic (US) grey scale (GS) and power Doppler (PD) assessment of synovitis in rheumatoid arthritis (RA). Methods: Patients with RA taking NSAIDs were randomised to either stopping (for a minimum of 5...

Effectiveness of intra-articular hyaluronan (Synvisc, hylan G-F 20) for the treatment of first metatarsophalangeal joint osteoarthritis: a randomised placebo-controlled trial

Annuals of Rheumatic Diseases (Jul 2011)

Objectives: To evaluate the effectiveness of a single intra-articular injection of hylan G-F 20 (Synvisc) for symptomatic first metatarsophalangeal joint (MTPJ) osteoarthritis (OA). Methods: Participants (n = 151) with symptomatic first MTPJ OA were randomly allocated to receive up to 1 ml intra-articular injection of...

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

Annuals of Rheumatic Diseases (Jun 2011)

Objective: Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population. Material and Methods: A cross-sectional...

Appetite

Explaining Dietary Intake in Adolescent Girls from Disadvantaged Secondary Schools: A Test of Social Cognitive Theory

Appetite (Dec 2011)

Much of the research on the determinants of dietary behavior has been guided by Bandura’s Social Cognitive Theory (SCT), yet few studies have tested the utility of its proposed structural paths. The aim of this paper was to test the capacity of SCT to explain dietary behaviors in a sample of 357 adolescent girls (13.2...

Applied Physiology

Current markers of the Athlete Blood Passport do not flag microdose EPO doping

Applied Physiology (Feb 2011)

The Athlete Blood Passport is the most recent tool adopted by anti-doping authorities to detect athletes using performance-enhancing drugs such as recombinant human erythropoietin (rhEPO). This strategy relies on detecting abnormal variations in haematological variables caused by doping, against a background of...

Archives of Gerontology and Geriatrics

Quality of life (QoL) in community-dwelling and institutionalized Alzheimer's disease (AD) patients

Archives of Gerontology and Geriatrics (May 2013)

The purpose of this study was to describe and compare QoL and its determinants in two groups of patients with AD that differed in place of residence: community or nursing home. This study covered 200 patients with AD (mean age 79.3±8.2 years, 74% female). Fifty-four per cent of the subjects were living in a nursing...

Interaction of white matter hyperintensities (WMHs) and apolipoprotein E (APOE) genotypes on cognition in patients with amnestic mild cognitive impairment (aMCI)

Archives of Gerontology and Geriatrics (May 2013)

The clinical implications of WMHs in aMCI are inconclusive. Moreover, clinical interactions between APOE genotypes and WMHs remain unclear. This study was conducted to investigate the relationship between WMHs and cognitive functions and how this relationship interacted with APOE genotype in people with aMCI. This...

Determinants of emergency medical utilization among the elderly population in Taiwan: A national longitudinal cohort study

Archives of Gerontology and Geriatrics (Nov 2012)

The aim of this study was to evaluate the potential determinants for emergency medical utilization by elderly patients in Taiwan. The data were drawn from the ‘Survey of Health and Living Status of the Elderly in Taiwan’, a population-based, longitudinal study of a nationally representative random sample of older...

Short Form 36-Item Health Survey test result on the empty nest elderly in China: A meta-analysis

Archives of Gerontology and Geriatrics (Nov 2012)

The aim of this study was to evaluate the quality of life of the empty nest elderly in China using meta-analytic techniques. Electronic databases were searched for studies concerning the quality of life of the empty nest elderly published before December 2011. Pooled weighted mean difference (WMD) and 95% confidence...

Muscle strength is the main associated factor of physical performance in older adults with knee osteoarthritis regardless of radiographic severity

Archives of Gerontology and Geriatrics (Nov 2012)

The aim of the study is to compare factors associated with physical performance in older individuals with severe knee osteoarthritis and those with less-severe osteoarthritis. This is an ancillary cross-sectional study to a population-based cohort study focusing on Koreans age 65 years or older. The analysis included...

Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly

Archives of Gerontology and Geriatrics (Nov 2012)

Prognostic values of N-terminal pro-brain natriuretic peptide (NT-proBNP) in myriad diseases have been studied. During the natural progression of atherosclerotic renal artery disease (ARVD) changes of NT-proBNP levels and its significance is not understood. A prospective longitudinal follow-up study was conducted among...

Gender differences in factors influencing sexual satisfaction in Korean older adults

Archives of Gerontology and Geriatrics (Nov 2012)

This study investigates the sex lives of Korean older adults (i.e., those over 60 years) and attempts to identify gender-related factors influencing sexual satisfaction. It used data from the 2008 Korean National Survey on Older Adults conducted by the Ministry of Health, Welfare, and Families. Of the 15,146...

Change in sense of coherence (SOC) and symptoms of depression among old non-demented persons 12 months after hospitalization

Archives of Gerontology and Geriatrics (Nov 2012)

We studied whether SOC of older adults (≥65 years) without cognitive impairment had changed 1-year after medical hospitalization (T2) and to examine what factors were associated with the change. At baseline (T1) and (T2), the 13-item version of the SOC scale assessed coping, and the Hospital Anxiety and Depression...

Correlation between moderate daily physical activity and neurocognitive variability in healthy elderly people

Archives of Gerontology and Geriatrics (Nov 2012)

Recent studies have reported that moderate physical activity in daily life contributes to maintenance of a proper state of cognitive function in elderly individuals. The present study investigated the validity of correlations between moderate physical activity and cognitive function using more objective and detailed...

Grip strength in a cohort of older medical inpatients in Malaysia: A pilot study to describe the range, determinants and association with length of hospital stay

Archives of Gerontology and Geriatrics (Oct 2012)

Grip strength is a marker of sarcopenia, the age-related decline in muscle mass and function, and has been little researched in Asian populations. We aimed to describe the feasibility and acceptability of measuring grip strength in hospitalized, older people in Malaysia and to explore its range, determinants and...

Homebound status increases death risk within two years in the elderly: Results from a national longitudinal survey

Archives of Gerontology and Geriatrics (Oct 2012)

Homebound status is associated with poorer physical and mental health, as well as disability in the elderly. We aimed to examine the prevalence and the role of homebound status on mortality in a representative sample of the French non-institutionalized population. This study included 7497 people aged 65 and over who...

History of depression prior to Alzheimer's disease and vascular dementia verified post-mortem

Archives of Gerontology and Geriatrics (Oct 2012)

The aim of this study was to analyze the medical history, with regards to previous remote depression, in patients with neuropathologically verified Alzheimer's disease (AD), vascular dementia (VaD) and mixed AD/VaD. The 201 patients included (115 AD, 44 VaD and 42 mixed AD/VaD) had been referred to the...

Health status and associated factors among the community-dwelling elderly in China

Archives of Gerontology and Geriatrics (Oct 2012)

The objective of this study was to evaluate the health status and associated factors of the elderly Chinese population. A cross-sectional survey was administered to 849 elderly people aged 60 years and over living in a certain district of Nanjing, China. A health rating scale based on the characteristics of the elderly...

Associations between sex hormones and cognitive and neuropsychiatric manifestations in vascular dementia (VaD)

Archives of Gerontology and Geriatrics (Oct 2012)

Although numerous studies have been carried out to determine the effects of sex hormones on Alzheimer's disease (AD), little is known about the associations between sex hormones and VaD. The aim of this study was to compare serum sex hormone levels between VaD patients and normal controls, and to further determine the...

Is increased red cell distribution width (RDW) indicating the inflammation in Alzheimer's disease (AD)?

Archives of Gerontology and Geriatrics (Oct 2012)

Increasing evidence indicates that inflammation has a substantial role in the pathogenesis and progression of AD. RDW, a measure of heterogeneity in the size of circulating erythrocytes, is associated with inflammatory markers in many numerous diseases. Present study was undertaken to assess the interrelationships...

Free wall rupture (FWR) in patients with acute ST-elevation myocardial infarction (STEMI) receiving fibrinolytic therapy (FT): A 7-year prospective study.

Archives of Gerontology and Geriatrics (Apr 2011)

Previous studies have shown a paradoxical increase in early mortality in older patients (>70 years) with acute STEMI treated with fibrinolytic therapy (FT), which has been attributed to the development of free wall rupture (FWR). Our aim was to assess occurrence of FWR in STEMI patients receiving FT. In this 7-year...

C-reactive protein (CRP): An important diagnostic and prognostic tool in nursing-home-associated pneumonia

Archives of Gerontology and Geriatrics (Mar 2011)

Pneumonia is the second most common infection in long term care (LTC) residents and is a leading cause of death from infection in those groups of patients. Atypical presentations and fewer presenting signs and symptoms in older patients complicate diagnosis and delay initiation of adequate treatment. The aim of this...

Prior antiplatelet drug use and short-term mortality in older patients with acute ischemic stroke (AIS)

Archives of Gerontology and Geriatrics (Feb 2011)

Some studies suggest that previous treatment with antiplatelet agents (AA) might reduce ischemic stroke severity and improve outcomes in terms of clinical deficits or mortality. We evaluated the effect of the prior chronic use of AA on short-term (30 days) mortality in a sample of consecutive patients with AIS. Four...

Malnutrition in an elderly demented population living at home

Archives of Gerontology and Geriatrics (Jan 2011)

Malnutrition is a frequent complication for elderly demented patients even if they live at their own home with the assistance of a caregiver. The present study evaluates nutritional characteristics of a population of 130 non-institutionalized demented patients. The results show that the mini nutritional assessment...

Dysfunction of pre- and post-operative cardiac autonomic nervous system in elderly patients with diabetes mellitus

Archives of Gerontology and Geriatrics (Jan 2011)

The pre- and post-operative cardiac autonomic nervous functions were compared in elderly, non-cardiac surgery patients with diabetes mellitus (DM) and without diabetes mellitus (NDM). A group of 30 unpremedicated elderly patients scheduled to undergo elective non-cardiac surgery were studied, including 15 DM patients...

Allergic rhinitis (AR) in geriatric patients

Archives of Gerontology and Geriatrics (Jan 2011)

Allergic rhinitis (AR) can be defined as an inflammatory disease of the nose and the paranasal sinuses, characterized by a specific IgE-mediated hypersensitivity reaction. The aim of this study was to evaluate the correlation between the symptoms of AR and the prick test results in geriatric patients presenting with...

How family support affects physical activity (PA) among middle-aged and elderly people before and after they suffer from chronic diseases

Archives of Gerontology and Geriatrics (Jan 2011)

The more support elderly people have from their family, the less likely they are to suffer from chronic diseases. The objective of this study is to investigate how family support affects the PA middle-aged and elderly people engage in before and after they suffer from chronic diseases. We interviewed 428 middle-aged...

Archives of Physical Medicine and Rehabilitation

Unsupervised Virtual Reality-Based Exercise Program Improves Hip Muscles Strength and Balance Control in the Elderly: A Pilot Study

Archives of Physical Medicine and Rehabilitation (Dec 2012)

Objective: To assess the effects of an unsupervised virtual reality (VR)-based exercise program on hip muscles strength and balance control in the elderly. Design: Controlled cohort repeated-measures experimental design, a pilot study Setting: University research laboratory Participants: Thirty-two ambulatory older...

Is it possible to individualize Intensity of Eccentric Cycling Exercise from Perceived Exertion on Concentric Test?

Archives of Physical Medicine and Rehabilitation (Dec 2012)

Objective: To assess the safety and acute effects of a procedure using perceived exertion during a prior submaximal concentric (CON) test to individualize eccentric (ECC) cycling exercise intensity. Design: Prospective monocentric open study. Setting: Technological Investigation Platform at the Physical Medicine and...

Usefulness of a Myofascial Trigger Point Injection for Groin Pain in patients with CP/CPPS: A Pilot Study

Archives of Physical Medicine and Rehabilitation (Dec 2012)

Objective: To investigate the therapeutic effectiveness of trigger point injection into the muscles around the groin in patients with a clinically diagnosed chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Design: Prospective, unicenter trial. Setting: University rehabilitation hospital. Participants:...

Emotional Vitality: Concept of Importance for Rehabilitation

Archives of Physical Medicine and Rehabilitation (Dec 2012)

Objective: To provide a framework for the conceptualization of emotional vitality as an important construct for rehabilitation professionals. The specific objectives are to outline the existing scope and breadth of knowledge currently available regarding the definition and measurement of emotional vitality in persons...

Satisfaction and problems experienced with transfemoral suspension systems: a comparison between common suction socket and Seal-In liner

Archives of Physical Medicine and Rehabilitation (Dec 2012)

Objective: To compare a seal-in liner with the common suction socket with regards to patient satisfaction and problems experienced with the prosthesis. Design: Retrospective survey. Setting: Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran and Department of Biomedical Engineering, Faculty of...

Comparison of the effects of vapocoolant spray and topical anesthetic cream on pain during needle electromyography in the medial gastrocnemius

Archives of Physical Medicine and Rehabilitation (Dec 2012)

Objective(s): To compare the effects of a vapocoolant spray and a eutectic mixture of local anesthetics (EMLA) cream in reducing pain during needle EMG examination. Design: A randomized controlled clinical trial. Setting: The Physical Medicine and Rehabilitation Department of a university hospital. Participants: In...

Radial Nerve Mobilization Decreases Pain Sensitivity and Improves Motor Performance in Patients With Thumb Carpometacarpal Osteoarthritis: A Randomized Controlled Trial

Archives of Physical Medicine and Rehabilitation (Jan 2012)

Objective: To examine the effects of radial nerve mobilization on pain sensitivity and motor performance in subjects with secondary thumb carpometacarpal osteoarthritis. Design: Randomized controlled trial. Treatment and placebo were given for 4 weeks. Measurements were taken before intervention, after 1 month (first...

Gait Training in Human Spinal Cord Injury Using Electromechanical Systems: Effect of Device Type and Patient Characteristics

Archives of Physical Medicine and Rehabilitation (Jan 2012)

Objective: To report the clinical improvements in spinal cord injury (SCI) patients associated with intensive gait training using electromechanical systems according to patient characteristics. Design: Prospective longitudinal study. Setting: Inpatient SCI rehabilitation center. Participants: Adults with SCI (n=130)....

Comparison of High- and Low-Dose Corticosteroid in Subacromial Injection for Periarticular Shoulder Disorder: A Randomized, Triple-Blind, Placebo-Controlled Trial

Archives of Physical Medicine and Rehabilitation (Nov 2011)

Objective: To determine whether subacromial injection with high-dose corticosteroid in patients with periarticular shoulder disorders is better than low-dose corticosteroid or placebo in improving pain, function, and active range of motion (AROM). Design: Multicenter, randomized, triple-blind, placebo-controlled trial....

A Randomized Controlled Trial to Investigate the Effects of Water-Based Exercise to Improve Falls Risk and Physical Function in Older Adults With Lower-Extremity Osteoarthritis

Archives of Physical Medicine and Rehabilitation (Oct 2011)

Objective: To investigate the efficacy of a water-based exercise program specifically targeting balance to reduce falls risk and improve measures of balance and physical function in older adults with osteoarthritis (OA). Design: Randomized controlled trial. Setting: Community. Participants: Persons (N=39; mean±SD age,...

Arteriosclerosis, Thrombosis and Vascular Biology

Role for the Guanine Nucleotide Exchange Factor Phosphatidylinositol-3,4,5-Trisphosphate–Dependent Rac Exchanger 1 in Platelet Secretion and Aggregation

Arteriosclerosis, Thrombosis and Vascular Biology (Dec 2011)

Objective: Recent studies have shown a role for Rac1 in regulating platelet functions, but how Rac1 is activated in platelets remains unclear. Phosphatidylinositol-3,4,5-trisphosphate–dependent Rac exchanger 1 (P-Rex1) was originally identified in neutrophils that regulates phagocyte functions. We sought to examine...

Arthritis & Rheumatism

Premature Cell Senescence and T Cell Receptor–Independent Activation of CD8+ T Cells in Juvenile Idiopathic Arthritis

Arthritis & Rheumatism (Jul 2013)

Background:

New strategies to prolong disease control warrant investigation in patients with metastatic pancreatic adenocarcinoma. This open-label, randomised, multi-centre phase II trial explored the role of maintenance sunitinib after first-lin...

Osteoprotegerin Causes Apoptosis of Endothelial Progenitor Cells by Induction of Oxidative Stress

Arthritis & Rheumatism (Jul 2013)

Objective:

Elevated serum osteoprotegerin (OPG) levels represent an independent risk factor for atherosclerotic disease, although the underlying mechanism is not clear. The aim of this study was to investigate the association of serum OPG levels and circulating endothelial progenitor cell (EPC) numbers, and to...

DNASE1L3 Mutations in Hypocomplementemic Urticarial Vasculitis Syndrome

Arthritis & Rheumatism (Jul 2013)

Objective:

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is characterized by recurrent urticaria along with dermal vasculitis, arthritis, and glomerulonephritis. Systemic lupus erythematosus (SLE) develops in >50% of patients with HUVS, although the pathogenesis is unknown. The aim of this study was...

The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis

Arthritis & Rheumatism (Jul 2013)

Objective:

Inflammatory arthritis is associated with systemic manifestations including alterations in metabolism. We used nuclear magnetic resonance (NMR) spectroscopy–based metabolomics to assess metabolic fingerprints in serum from patients with established rheumatoid arthritis (RA) and those with early...

Transcriptome Analysis of Injured Human Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration With Aging

Arthritis & Rheumatism (Jul 2013)

Objective:

Meniscus tears are associated with a heightened risk of osteoarthritis. This study aimed to advance our understanding of the metabolic state of injured human meniscus at the time of arthroscopic partial meniscectomy through transcriptome-wide analysis of gene expression in relation to the patient's...

Validation of the Methotrexate-First Strategy in Patients With Early, Poor-Prognosis Rheumatoid Arthritis: Results From a Two-Year Randomized, Double-Blind Trial

Arthritis & Rheumatism (Jul 2013)

Objective:

Methotrexate (MTX) taken as monotherapy is recommended as the initial disease-modifying antirheumatic drug for rheumatoid arthritis (RA). The purpose of this study was to examine outcomes of a blinded trial of initial MTX monotherapy with the option to step-up to combination therapy as compared to...

Sonographic Joint Assessment in Rheumatoid Arthritis: Associations With Clinical Joint Assessment During a State of Remission

Arthritis & Rheumatism (Jul 2013)

Objective:

Sonography, as compared with clinical assessment, is a sensitive tool for evaluating synovitis in rheumatoid arthritis (RA). However, differences between these assessment tools may depend on how joint activity (i.e., an active joint) is defined. The present study was undertaken to compare clinically...

Stimulation of Fibrotic Processes by the Infrapatellar Fat Pad in Cultured Synoviocytes From Patients With Osteoarthritis: A Possible Role for Prostaglandin F

Arthritis & Rheumatism (Jul 2013)

Objective:

Stiffening of the joint is a feature of knee osteoarthritis (OA) that can be caused by fibrosis of the synovium. The infrapatellar fat pad (IPFP) present in the knee joint produces immune-modulatory and angiogenic factors. The goal of the present study was to investigate whether the IPFP can...

Protein Kinase Cδ Deficiency Causes Mendelian Systemic Lupus Erythematosus With B Cell-Defective Apoptosis and Hyperproliferation

Arthritis & Rheumatism (Jul 2013)

Objective:

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that is assumed to occur via a complex interplay of environmental and genetic factors. Rare causes of monogenic SLE have been described, providing unique insights into fundamental mechanisms of immune tolerance. The aim of this...

Patellofemoral Joint Loading During Stair Ambulation in People With Patellofemoral Osteoarthritis

Arthritis & Rheumatism (Jul 2013)

Objective:

To determine whether people with patellofemoral (PF) joint osteoarthritis (OA) ascend and descend stairs with different PF joint loading, knee joint moments, lower limb kinematics, and muscle forces compared to healthy people.

Methods:

We recruited 17 participants with isolated PF joint...

Relatives Without Rheumatoid Arthritis Show Reactivity to Anti–Citrullinated Protein/Peptide Antibodies That Are Associated With Arthritis-Related Traits: Studies of the Etiology of Rheumatoid Arthritis

Arthritis & Rheumatism (Jul 2013)

Objective:

To examine reactivity to anti–citrullinated protein/peptide antibodies (ACPAs) and determine associations between ACPAs and other rheumatoid arthritis (RA)–related autoantibodies and clinically assessed swollen or tender joints in unaffected first-degree relatives of RA...

Angiogenesis in Rheumatoid Arthritis Is Fostered Directly by Toll-like Receptor 5 Ligation and Indirectly Through Interleukin-17 Induction

Arthritis & Rheumatism (Jul 2013)

Objective:

To examine the impact of Toll-like receptor 5 (TLR-5) on endothelial cell function in rheumatoid arthritis (RA) and vascularization in collagen-induced arthritis (CIA).

Methods:

Endothelial cell migration and tube formation assays were used to demonstrate the direct role of TLR-5...

Magnetic Resonance Imaging–Based Three-Dimensional Bone Shape of the Knee Predicts Onset of Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Arthritis & Rheumatism (Jul 2013)

Objective:

To examine whether magnetic resonance imaging (MRI)–based 3-dimensional (3-D) bone shape predicts the onset of radiographic knee osteoarthritis (OA).

Methods:

We conducted a case–control study using data from the Osteoarthritis Initiative by identifying knees that developed incident...

Baseline Predictors of Systemic Lupus Erythematosus Flares: Data From the Combined Placebo Groups in the Phase III Belimumab Trials

Arthritis & Rheumatism (Jul 2013)

Objective:

To identify predictors of moderate-to-severe systemic lupus erythematosus (SLE) flare in 562 patients treated with standard therapy alone in phase III belimumab trials, and to evaluate the impact of standard therapies on preventing flares.

Methods:

Post hoc analysis assessed baseline...

Transcription Factor Mohawk and the Pathogenesis of Human Anterior Cruciate Ligament Degradation

Arthritis & Rheumatism (Jul 2013)

Objective:

To investigate the expression and function of Mohawk (MKX) in human adult anterior cruciate ligament (ACL) tissue and ligament cells from normal and osteoarthritis (OA)–affected knees.

Methods:

Knee joints were obtained at autopsy (within 24–48 hours postmortem) from 13 donors with...

Effect of Renal Disease on the Standardized Mortality Ratio and Life Expectancy of Patients With Systemic Lupus Erythematosus

Arthritis & Rheumatism (Jul 2013)

Objective:

To study the effect of renal disease on the standardized mortality ratio (SMR) and life expectancy of patients with systemic lupus erythematosus (SLE).

Methods:

Patients whose diagnosis met ≥4 American College of Rheumatology criteria for SLE were longitudinally followed up from 1995 to...

Brain Morphometric Changes Associated With Childhood-Onset Systemic Lupus Erythematosus and Neurocognitive Deficit

Arthritis & Rheumatism (Jul 2013)

Objective:

To use structural magnetic resonance imaging (MRI) to characterize changes in gray matter and white matter volumes between patients with childhood-onset systemic lupus erythematosus (SLE) and matched controls, between patients with childhood-onset SLE with and those without neurocognitive deficit,...

Baseline predictors of systemic lupus erythematosus flares: Data from the combined placebo groups in the Phase 3 belimumab trials

Arthritis & Rheumatism (Jun 2013)

Objective: Identify predictors of moderate–severe systemic lupus erythematosus (SLE) flare in 562 patients treated with standard therapy alone in phase 3 belimumab trials and evaluate impact of standard therapies on preventing flares. Methods: Post-hoc analysis assessed baseline demographics, disease activity, and...

Clinical outcomes of remission induction therapy for severe ANCA-Associated vasculitis

Arthritis & Rheumatism (Jun 2013)

Objective: We analyzed the reasons for primary outcome failure in the Rituximab in ANCA-associated Vasculitis (RAVE) trial. Methods: Randomized trial comparing rituximab (RTX, n=99) to cyclophosphamide (CYC) followed by azathioprine (AZA, n=98) for remission induction. Glucocorticoids were tapered over 5 months. The...

Effect of renal disease on standardized mortality ratio and life expectancy of patients with systemic lupus erythematosus

Arthritis & Rheumatism (Jun 2013)

Objectives: To study the effect of renal disease on standardized mortality ratio (SMR) and life expectancy of patients with systemic lupus erythematosus (SLE). Method: Patients with ≥4 ACR criteria for SLE who were longitudinally followed from 1995 to 2011 were studied. The cumulative survival rate, SMR and life...

High resolution MRI of arthritic murine ankle joints discriminates inflammation and bone destruction in a quantifiable manner

Arthritis & Rheumatism (Jun 2013)

Background: The ability to non-invasively monitor the development of inflammatory arthritis longitudinally has become increasingly important in experimental rheumatology. Magnetic resonance imaging (MRI) allows for detailed examination of anatomical structures as well as the assessment of joint and soft tissue...

Efficacy and Safety of Ocrelizumab in Active Proliferative Lupus Nephritis: Results from the Randomized, Double-Blind Phase III BELONG Study

Arthritis & Rheumatism (Jun 2013)

Introduction: This study investigated the efficacy and safety of ocrelizumab (OCR) in patients with class III/IV lupus nephritis (LN). Methods: Patients received intravenous placebo, OCR 400 mg, or OCR 1,000 mg (days 1 and 15, week 16, then every 16 weeks) with background glucocorticoids plus either mycophenolate...

Survival and prognostic factors in systemic sclerosis-associated pulmonary hypertension: A systematic review and meta-analysis

Arthritis & Rheumatism (Jun 2013)

Objective: Pulmonary hypertension (PH) is a frequent and life-limiting complication of systemic sclerosis (SSc). However, there are still conflicting data on the survival rates, their evolution over time as well as on prognostic factors in this complication. Methods: We performed a systematic review and meta-analysis...

The impact of inflammation on metabolomic profiles in patients with arthritis

Arthritis & Rheumatism (Jun 2013)

Objectives: Inflammatory arthritis is associated with systemic manifestations including alterations in metabolism. We have used NMR spectroscopy-based metabolomics to assess metabolite fingerprints in serum from patients with established rheumatoid arthritis (RA) and early arthritis. Methods: Serum samples were...

Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation

Arthritis & Rheumatism (May 2013)

Objective: To investigate the expression and function of Mohawk (MKX) in human adult anterior cruciate ligament (ACL) tissues and ligament cells from normal and osteoarthritis-affected knees. Methods: Knee joints were obtained at autopsy within 24-48 hours postmortem from 13 normal donors (age 36.9±11.0 years), 16 OA...

Anti-cyclic citrullinated peptide assays differ in subjects at elevated risk for rheumatoid arthritis and subjects with established disease

Arthritis & Rheumatism (May 2013)

Objective: To compare commonly-available tests for antibodies to citrullinated protein antigens (ACPAs) for diagnostic accuracy and assay agreement in established rheumatoid arthritis (RA) and subjects at elevated risk for RA. Methods: ELISA testing for anti-cyclic citrullinated peptide (anti-CCP) antibodies was...

Sonographic joint assessment in rheumatoid arthritis: Associations with clinical joint assessment in remission

Arthritis & Rheumatism (May 2013)

Background: Sonography is a sensitive tool for evaluating synovitis in rheumatoid arthritis (RA) compared with clinical assessment. However, differences between these assessments may depend on how “joint activity” is defined. Therefore, we compared clinically vs. sonographically active joints in RA by different...

Premature cell senescence and T cell receptor-independent activation of CD8T cells in Juvenile Idiopathic Arthritis

Arthritis & Rheumatism (May 2013)

Objectives: CD8T cells lacking CD28 were originally reported by Wedderburn and colleagues as a characteristic feature of JIA, but the relevance of these unusual cells to JIA remains to be elucidated. Because of recent evidence that CD28 loss is typical of terminally differentiated lymphocytes, we examined for...

Validation of methotrexate-first strategy in early poor prognosis rheumatoid arthritis: Results from a randomized, double-blind, 2-year trial

Arthritis & Rheumatism (May 2013)

Objective: Methotrexate (MTX) monotherapy (MM) is recommended as the initial rheumatoid arthritis (RA) DMARD. We demonstrate for the first time in a blinded trial that initial MTX (IM) with the option to step-up to combination therapy results in similar outcomes to initial combination therapy (IC). Methods: The TEAR...

Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout; A pilot randomised controlled trial

Arthritis & Rheumatism (May 2013)

Objective: Studies in human volunteers have shown that vitamin C reduces serum urate (SU). The aim of this study was to determine effects of vitamin C on SU in patients with gout. Methods: Patients with gout and SU >0.36mmol/L were recruited. 20 patients already receiving allopurinol were randomised to an increase in...

Variants in RUNX3 Contribute to Susceptibility to Psoriatic Arthritis, Exhibiting Further Common Ground With Ankylosing Spondylitis

Arthritis & Rheumatism (Apr 2013)

Objective: Psoriatic arthritis (PsA) is a common inflammatory joint disease distinct from other chronic arthritides and frequently accompanied by psoriasis vulgaris. In a first genome-wide association study (GWAS), we were able to identify several genetic risk factors. However, even combined with previously identified...

Which Patients Are Most Likely to Benefit From Total Joint Arthroplasty?

Arthritis & Rheumatism (Apr 2013)

Objective: To evaluate patient predictors of good outcome following total joint arthroplasty (TJA). Methods: A population cohort with hip/knee arthritis (osteoarthritis [OA] or inflammatory arthritis) ages ≥55 years was recruited between 1996 and 1998 (baseline) and assessed annually for demographics, troublesome...

Circulating citrullinated vimentin fragments reflect disease burden in Ankylosing Spondylitis and has prognostic capacity for radiographic progression

Arthritis & Rheumatism (Dec 2012)

Objective: Ankylosing spondylitis (AS) is considered a seronegative disease indicated by absent or low levels of antibodies against citrullinated proteins. We evaluated whether a citrullinated and MMP degraded fragment of vimentin (VICM) could be a prognostic biomarker in AS. Methods: Serum VICM was measured in samples...

The fibromyalgia family study: A genome-scan linkage study

Arthritis & Rheumatism (Dec 2012)

Objective: Familial aggregation of fibromyalgia has been increasingly recognized. The goal of the current study was to conduct a genome wide linkage scan to identify susceptibility loci for fibromyalgia. Methods: We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free...

The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling

Arthritis & Rheumatism (Dec 2012)

Objective: To elucidate whether the microRNA (miRNA) cluster miR-17-92 contributes to the activated phenotype of rheumatoid arthritis synovial fibroblasts (RASF). Methods: RASF were stimulated with tumor necrosis factor alpha (TNFα? and expression and regulation of the miR-17-92 cluster were studied using quantitative...

TNF inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a TNF driven model of rheumatoid arthritis

Arthritis & Rheumatism (Dec 2012)

Objective: To investigate how TNF inhibiting therapy effects bone destruction and inflammation in a TNF-driven animal model of rheumatoid arthritis. Methods: To evaluate the influence of TNF on osteoclastogenesis in vitro, we added different concentrations of TNF to spleen cell derived monocytes in the absence or...

p53 controls autoimmune arthritis via the STAT3/STAT5-mediated regulation of the Th17–Treg balance

Arthritis & Rheumatism (Dec 2012)

Objective: To investigate the connection between p53 and interleukin (IL)-17–producing helper T (Th17)/regulatory T (Treg) balance in rheumatoid arthritis (RA). Methods: Th17 and Treg cell frequencies were analyzed by flow cytometry and cytokine levels in the supernatant were determined using enzyme-linked...

Neutrophil cannibalismtriggers TGF-β1 production andself-regulation of neutrophil inflammatory function in MSU crystal-induced inflammation

Arthritis & Rheumatism (Dec 2012)

Objectives: To identify macrophage-independent sources of transforming growth factor-β1 (TGF-β1) production during monosodium urate monohydrate (MSU) crystal-induced inflammation and determine how TGF-β1 alters MSU crystal-recruited neutrophil functions. Methods: C57BL/6J mice were injected intraperitoneally with MSU...

Arthritis & Rheumatology

Ankylosing Spondylitis, Psoriatic Arthritis, and Risk of Malignant Lymphoma: A Cohort Study Based on Nationwide Prospectively Recorded Data From Sweden

Arthritis & Rheumatology (Apr 2014)

Objective

Data on lymphoma risk in ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are scarce. This study was undertaken to assess the risk of lymphoma in AS and PsA overall and in relation to therapies, including tumor necrosis factor inhibitor (TNFi), for which lymphoma risks are a...

Fcγ Receptor IIIa Single–Nucleotide Polymorphisms and Haplotypes Affect Human IgG Binding and Are Associated With Lupus Nephritis in African Americans

Arthritis & Rheumatology (Apr 2014)

Objective:

To investigate whether the Fcγ receptor IIIa–66L/R/H (FcγRIIIa–66L/R/H) polymorphism influences net effective receptor function and to assess if the FCGR3A combined genotypes formed by FcγRIIIa–66L/R/H and FcγRIIIa–176F/V, as well as copy...

Arthritis and Rheumatism

CCL19, a B Cell Chemokine, Is Related to the Decrease of Blood Memory B Cells and Predicts the Clinical Response to Rituximab in Patients With Rheumatoid Arthritis

Arthritis and Rheumatism (Aug 2013)

Objective:

Migration of B cells from peripheral blood to the synovium in patients with rheumatoid arthritis (RA) may predict clinical response to rituximab (RTX). We undertook this study to investigate whether serum levels of chemokines involved in B cell trafficking are correlated with blood levels of memory...

Performance of Anti–Cyclic Citrullinated Peptide Assays Differs in Subjects at Increased Risk of Rheumatoid Arthritis and Subjects With Established Disease

Arthritis and Rheumatism (Aug 2013)

Objective:

To compare the diagnostic accuracy and agreement of commonly available assays for anti–citrullinated protein antibodies in patients with established rheumatoid arthritis (RA) and subjects at increased risk of RA.

Methods:

Tests for anti–cyclic citrullinated peptide (anti-CCP) antibodies...

Selective Blockade of Tumor Necrosis Factor Receptor I Inhibits Proinflammatory Cytokine and Chemokine Production in Human Rheumatoid Arthritis Synovial Membrane Cell Cultures

Arthritis and Rheumatism (Aug 2013)

Objective:

To determine whether selective blockade of tumor necrosis factor receptor I (TNFRI) affects spontaneous proinflammatory cytokine and chemokine production in ex vivo–cultured human rheumatoid arthritis synovial membrane mononuclear cells (MNCs) and to compare this response to that of TNF ligand...

Stress Doppler Echocardiography in Systemic Sclerosis: Evidence for a Role in the Prediction of Pulmonary Hypertension

Arthritis and Rheumatism (Aug 2013)

Objective:

Patients with systemic sclerosis (SSc) in whom pulmonary hypertension (PH) is not suspected have been reported to develop an inappropriate increase of pulmonary artery systolic pressure as estimated by Doppler echocardiography under conditions of exercise (pulmonary artery systolic pressure under...

Survival and Prognostic Factors in Systemic Sclerosis–Associated Pulmonary Hypertension: A Systematic Review and Meta-Analysis

Arthritis and Rheumatism (Aug 2013)

Objective:

Pulmonary hypertension (PH) is a frequent and life-limiting complication of systemic sclerosis (SSc). However, data on survival rates and their evolution over time, as well as prognostic factors in SSc complicated by PH, are still conflicting. The aim of this study was to conduct a systematic review...

Behçet's Disease and Pregnancy

Arthritis and Rheumatism (Aug 2013)

Objective:

To describe the interplay between Behçet's disease (BD) and pregnancy.

Methods:

This retrospective study included 76 pregnancies in 46 patients fulfilling the international criteria for BD. The median age of the patients at the time of entry into the study was 28.4 years (interquartile...

Long-Term Safety and Efficacy of Rilonacept in Patients With Systemic Juvenile Idiopathic Arthritis

Arthritis and Rheumatism (Aug 2013)

Objective:

To determine the long-term safety and efficacy of rilonacept, an anti–interleukin-1 fusion protein, in patients with active systemic juvenile idiopathic arthritis (JIA).

Methods:

In patients with systemic JIA, ages 4–20 years, the efficacy of rilonacept was evaluated using 30%, 50%, and...

Efficacy and Safety of Ocrelizumab in Active Proliferative Lupus Nephritis: Results From a Randomized, Double-Blind, Phase III Study

Arthritis and Rheumatism (Aug 2013)

Objective:

To investigate the efficacy and safety of ocrelizumab in patients with class III/IV lupus nephritis (LN).

Methods:

Patients were randomized 1:1:1 to receive placebo, 400 mg ocrelizumab, or 1,000 mg ocrelizumab given as an intravenous infusion on days 1 and 15, followed by a single...

Performance of Anti–Cyclic Citrullinated Peptide Assays Differs in Subjects at Increased Risk of Rheumatoid Arthritis and Subjects With Established Disease

Arthritis and Rheumatism (Aug 2013)

VLCD approaches for weight management in T2DM can achieve more than 90% of weight loss as compared with obese individuals without T2DM.

  • Identification of the need to investigate the full impact of this approach in patients with T2DM by assessing changes in glycaemia, liver function and...

  • Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis

    Arthritis and Rheumatism (Jul 2013)

    Objective: Hypothesis-generating study to identify skin transcripts correlating with severity of interstitial lung disease (ILD) in systemic sclerosis (SSc).

    Methods:

    Skin biopsy samples from 59 patients enrolled in the GENISOS cohort or an open label imatinib study (baseline visit) were examined by...

    Familial risks and heritability of RA in relation to RF/ACPA status, number and type of affected relatives, sex, and age

    Arthritis and Rheumatism (Jul 2013)

    Objective:

    To estimate the familial aggregation of RA in three large population-representative samples, and to test if the familial aggregation is modified by type of relative, sex, RF/ACPA-status, and age at RA onset.

    Methods:

    A Register-based nested case-control study was performed in the Swedish...

    ADAMTS4_v1 is a splice variant of ADAMTS4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain

    Arthritis and Rheumatism (Jul 2013)

    Objective:

    We have previously reported a mRNA variant of ADAMTS4 (ADAMTS4_v1) in human synovial cell co-cultures obtained from osteoarthritic patients. This RNA message has only been found in OA synovium and if translated would result in a protein identical to ADAMTS4 except that the C-terminal spacer domain...

    Arthritis and Rheumatology

    Rituximab for the treatment of relapses in ANCA–associated vasculitis

    Arthritis and Rheumatology (Jul 2014)

    Introduction:

    Disease relapses are frequent in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). We evaluated the outcomes of patients re–treated with rituximab (RTX) and prednisone for severe disease relapses.

    Methods:

    The Rituximab in AAV trial was a randomized,...

    Impaired suppressive capacity of activation–induced regulatory B cells in Systemic Lupus Erythematosus

    Arthritis and Rheumatology (Jun 2014)

    Objective:

    B–cells with immunoregulatory properties have been described in mice (Breg) but their role in control of human immune responses is ill defined. We recently identified a population of human activated FSChiB–cells which exhibited regulatory activity towards T–helper...

    Efficacy and safety of Adalimumab as first and second used biologic agent in juvenile idiopathic arthritis – the German Biologics JIA Registry (BiKeR)

    Arthritis and Rheumatology (Jun 2014)

    Objectives:

    To evaluate the efficacy and safety of adalimumab in patients with JIA.

    Methods:

    Baseline demographics, clinical characteristics and disease activity parameters have been prospectively documented in the German Biologics Registry (BiKeR). Efficacy was determined using the PedACR...

    Arthritis Care & Research

    Spinal mobility in patients with spondylitis is determined by age, structural damage, and inflammation

    Arthritis Care & Research (Jul 2014)

    Objective:

    To explore, in ankylosing spondylitis (AS), the association between mobility, inflammation, and structural damage.

    Methods:

    Patients with AS were included in a cross–sectional study in which spinal mobility was measured by the BASMI (Bath Ankylosing Spondylitis Metrology Index) and...

    Exercise therapy reduces pain sensitivity in patients with knee osteoarthritis: A randomized controlled trial

    Arthritis Care & Research (Jun 2014)

    Background:

    Exercise has beneficial effects on pain in knee osteoarthritis (OA), yet the underlying mechanisms are unclear. The purpose of this study was to investigate the effects of exercise on pressure pain sensitivity in patients with knee OA.

    Methods:

    In a randomized controlled trial...

    Functional impairments characterising mild, moderate and severe hallux valgus

    Arthritis Care & Research (Jun 2014)

    Objective:

    Hallux valgus has been linked to functional disability and increased falls risk, but mechanisms underpinning functional disability are unclear. This study investigated functional performance, muscle strength and plantar pressures in adults with mild, moderate, and severe HV compared to controls,...

    Predictors and outcome of pain–related avoidance of activities in persons with early symptomatic knee osteoarthritis: A 5–year follow–up study

    Arthritis Care & Research (Jun 2014)

    Objective:

    It has been hypothesized (i) that pain and low vitality lead to an increase in avoidance of activities in persons with early symptomatic knee osteoarthritis (OA), and (ii) that avoidance of activities leads to an increase in activity limitations. The present study aimed to evaluate these...

    Systemic Lupus Prevalence in Sweden in 2010: What do national registers say?

    Arthritis Care & Research (Apr 2014)

    Objective:

    Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3–207 per 100,000 depending on region and population, SLE definition, case sources and other methodological considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010 using...

    Hallux valgus and lesser toe deformities are highly heritable in adult men and women: The Framingham foot study

    Arthritis Care & Research (May 2013)

    Objective: To estimate heritability of three common disorders affecting the forefoot: hallux valgus, lesser toe deformities and plantar forefoot soft tissue atrophy in adult Caucasian men and women. Methods: Between 2002-2008, a trained examiner used a validated foot exam to document presence of hallux valgus, lesser...

    Clinical Features and Outcomes of Posterior Reversible Encephalopathy Syndrome in Patients with Systemic Lupus Erythematosus

    Arthritis Care & Research (May 2013)

    Objective: To analyze the clinical features and outcomes of patients with posterior reversible encephalopathy syndrome (PRES), the risk factors of PRES-related intracranial hemorrhage (ICH), and all-cause mortality in patients with systemic lupus erythematosus (SLE). Methods: Twenty-six episodes of PRES were identified...

    The utility of the PedsQL™ Rheumatology Module as an outcome measure in juvenile fibromyalgia

    Arthritis Care & Research (May 2013)

    Objective: The PedsQL™ Rheumatology Module is currently the only available measure of disease-specific Quality of Life (QOL) for children and adolescents with juvenile fibromyalgia (JFM) but limited information has been published about the psychometric properties of the instrument specifically in JFM. The objective of...

    Arthritis Care and Research

    Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin or pregabalin

    Arthritis Care and Research (Jul 2013)

    Background:

    Fibromyalgia is a common chronic pain disorder with unclear etiology. No definitive treatment is available for fibromyalgia and treatment with antidepressants or antiepileptics is often used for symptom management.

    Methods:

    Using US health care utilization data, a large population-based...

    Atherosclerosis

    Circumferential evaluation of the neointima by optical coherence tomography after ABSORB bioresorbable vascular scaffold implantation: Can the scaffold cap the plaque?

    Atherosclerosis (Jan 2012)

    Objective: To quantify the circumferential healing process at 6 and 12 months following scaffold implantation. Background: The healing process following stent implantation consists of tissue growing on the top of and in the space between each strut. With the ABSORB bioresorbable vascular scaffold (BVS), the outer...

    Auris Nasus Larynx

    Role of dynamic MRI in differentiating benign from malignant follicular thyroid nodule

    Auris Nasus Larynx (May 2011)

    Objectives: Thyroid nodular swellings are very common, consisting of both benign and malignant ones. Fine needle aspiration cytology is an excellent diagnostic modality for papillary cancers, medullary cancers, colloid goiter and lymphoma but fails in differentiating follicular adenomas from carcinomas. The purpose of...

    Management of intraoral needle migration into the posterior cervical space

    Auris Nasus Larynx (Feb 2011)

    Foreign bodies within the deep spaces of the neck pose infrequent but substantial risks involving migration, including infection, pseudoaneurysm formation, pneumothorax, hemopericardium, and embolization to the central circulation. A rare case of foreign body migration through the parapharyngeal space into the...

    Australasian Journal of Dermatology

    Associations between aberrant DNA methylation and transcript levels of DNMT1 and MBD2 in CD4+T cells from patients with systemic lupus erythematosus

    Australasian Journal of Dermatology (Nov 2012)

    Background/Objectives: It seems that global DNA hypomethylation in CD4+T cells is linked to the pathogenesis of systemic lupus erythematosus (SLE). However, the underlying mechanism by which SLE patients show hypomethylated DNA remains unclear. This study explored the relationship between DNA methylation patterns and...

    The protective effects of 6-CySeCD with GPx activity against UVB-induced injury in HaCaT cells

    Australasian Journal of Dermatology (Oct 2012)

    Background: The generation of harmful reactive oxygen species (ROS) induced by UVB irradiation could induce cell apoptosis and change the cell cycle. 6A,6A′-dicyclohexylamine-6B,6B′-diselenide-bis-β-cyclodextrin (6-CySeCD) is a novel glutathione peroxidase (GPx; EC 1.11.1.9) mimic. The aim of this study was to...

    Venous malformations: Clinical course and management of vascular birthmark clinic cases

    Australasian Journal of Dermatology (Oct 2012)

    Background/Objectives: Venous malformations (VM) are an uncommon vascular malformation with an estimated incidence of 1–2 per 10 000 births. The aim was to define the clinical characteristics and management of children with VM and develop a database for future research. Methods: A retrospective chart review of all...

    Frequency of positive patch test reactions to preservatives: The Australian experience

    Australasian Journal of Dermatology (Oct 2012)

    Background/Objectives: Preservatives are important causes of allergic contact dermatitis. The frequency of allergy to preservatives in Australia has been unknown to date. Our objectives are to report the frequency of positive preservative patch test reactions in Australia, comparing them to the published international...

    Office based dermatological surgery and Mohs surgery: A prospective audit of surgical procedures and complications in a procedural dermatology practice

    Australasian Journal of Dermatology (Oct 2012)

    Background/Objectives: Dermatologists commonly perform surgical procedures, including Mohs micrographic surgery, in an outpatient, office-based setting. Although this may be widely perceived to be safe and effective, formal data on the practice are limited. The aim of this study was to examine the range of surgical...

    Chronic vulvovaginal candidiasis: What we know and what we have yet to learn

    Australasian Journal of Dermatology (Sep 2012)

    Vulvovaginal candidiasis (VVC) is defined as vulvovaginitis, causally associated with Candida species in the vagina. It is seen commonly in vulval clinics as a cause of persistent vulvovaginitis and yet this chronic condition is yet to be formally defined and explained. The classic symptom complex of chronic itch, pain...

    Safety and efficacy of a non–pesticide-based head lice treatment: Results of a randomised comparative trial in children

    Australasian Journal of Dermatology (Jul 2012)

    Background/Objectives: Increasing resistance to pesticide-based head lice treatments has resulted in the need for alternative products to treat head lice infestations, but there are few clinical studies that have adequately tested these products. This multicentre, randomised, assessor-blind, parallel-group phase IV...

    Food allergy testing in infantile eczema: A clinical approach and algorithm

    Australasian Journal of Dermatology (Jun 2012)

    The complex relationship between food allergy and infantile eczema has prompted divergent approaches to investigating potential food triggers in eczematous patients. It is well recognised that a significant proportion of infants with eczema have immunoglobulin E-mediated food allergy, reported to range between 20–80%....

    Bangladesh Medical Research Council Bulletin

    Immature reticulocyte fraction as a predictor of bone marrow recovery in children with acute lymphoblastic leukaemia on remission induction phase

    Bangladesh Medical Research Council Bulletin (Sep 2011)

    Immature reticulocyte fraction a new routine parameter in the hematology analyzer can give the idea of the earliest morphologic change of bone marrow recovery before other test become positive after chemotherapy. A prospective observational study was carried out in the Department of Clinical Pathology in collaboration...

    Behavioural Brain Research

    Bone marrow derived mesenchymal stem cell transplantation in cerebellar degeneration: A behavioral study

    Behavioural Brain Research (Jun 2011)

    In addition to its key role in complex motor function, the cerebellum is increasingly recognized to have a role in cognition. Thus, motor and cognitive deficits can be associated with cerebellar degeneration. After unilateral lesion in cerebellum (folia VI) was caused by Quinolinic acid, CM-DiI labeled mesenchymal stem...

    Biological Psychiatry

    Cocaine Hydrolase Encoded in Viral Vector Blocks the Reinstatement of Cocaine Seeking in Rats for 6 Months

    Biological Psychiatry (Jan 2012)

    Background: Cocaine dependence is a pervasive disorder with high rates of relapse. In a previous study, direct administration of a quadruple mutant albumin-fused butyrylcholinesterase that efficiently catalyzes hydrolysis of cocaine to benzoic acid and ecgonine methyl ester acutely blocked cocaine seeking in an animal...

    Biology of Blood and Marrow Transplantation

    Hematopoietic Stem Cell Transplantation in Patients with Lymphomatoid Granulomatosis: A European Group for Blood and Marrow Transplantation (EBMT) Report

    Biology of Blood and Marrow Transplantation (Aug 2013)

    Lymphomatoid granulomatosis (LG) is a very rare, EBV-associated lymphoproliferative disorder of B-cells. Prognosis is poor particularly after relapse and no curative treatment exists. We report the results of high-dose therapy and autologous (ASCT) or reduced-intensity and allogeneic stem cell transplantation...

    Host Lymphocyte Depletion as a Strategy to Facilitate Early Engraftment Following Reduced Intensity Allogeneic Stem Cell Transplantation

    Biology of Blood and Marrow Transplantation (Aug 2013)

    Reduced intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (RIC-alloHSCT) is associated with lower toxicity but higher rates of prolonged mixed chimerism than myeloablative conditioning. Decreased pre-transplant host T-cell numbers are associated with less graft rejection and early full...

    Immunologic recovery in children after alternative donor allogeneic transplantation for hematologic malignancies: comparison of recipients of partially T-cell depleted peripheral blood stem cells and umbilical cord blood

    Biology of Blood and Marrow Transplantation (Aug 2013)

    Impaired immunologic recovery (IR) after hematopoietic stem cell transplantation (HSCT) is associated with increased risk for infections and relapse. Stem cell source and graft manipulation influence the kinetics of IR. Partial T-cell depletion (TCD) of peripheral blood stem cell (PBSC) grafts is a novel alternative...

    Trends in Utilization and Outcomes of Autologous Transplantation as Early Therapy for Multiple Myeloma

    Biology of Blood and Marrow Transplantation (Aug 2013)

    The impact of novel multiple myeloma (MM) drugs on the utilization and outcomes of autologous hematopoietic progenitor cell transplantation (AHPCT) is unknown. We reviewed characteristics and outcomes of 20,278 patients undergoing AHPCT within 12 months of MM diagnosis in the US and Canada and registered at the...

    Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease

    Biology of Blood and Marrow Transplantation (Aug 2013)

    We recently demonstrated that expression of α-defensins, the major antimicrobial peptides produced by Paneth cells was severely suppressed in mice with graft-versus-host disease (GVHD). In this study, we found that antibacterial lectin, regenerating islet-derived IIIγ (RegIIIγ) was upregulated in villous...

    IL-17 Gene Ablation Does Not Impact Treg-Mediated Suppression of Graft-Versus-Host Disease Following Bone Marrow Transplantation

    Biology of Blood and Marrow Transplantation (Aug 2013)

    Regulatory T cell immunotherapy is a promising strategy for the treatment of graft rejection responses and autoimmune disorders. Our and other laboratories have shown that the transfer of highly purified CD4+CD25+Foxp3+ natural regulatory T cells (Treg) can prevent lethal graft-versus host disease (GVHD)...

    Clostridium difficile Infection after Adult Autologous Stem Cell Transplantation: A Multicenter Study of Epidemiology and Risk Factors

    Biology of Blood and Marrow Transplantation (Aug 2013)

    We sought to describe the epidemiology of Clostridium difficile infection (CDI) among adult recipients of autologous hematopoietic stem cell transplantation (auto-HSCT) within the first year after HSCT in centers with variable epidemiology of hypertoxigenic strains. A multicenter, retrospective nested case-control...

    Enrichment of IL-12 producing plasmacytoid dendritic cells in donor bone marrow grafts enhances graft versus leukemia activity in allogeneic hematopoietic stem cell transplant

    Biology of Blood and Marrow Transplantation (Jun 2013)

    A critical question in the field of allogeneic hematopoietic stem cell transplantation (HSCT) is how to enhance graft-versus-leukemia (GvL) activity while limiting graft-versus-host-disease (GvHD). We have previously reported that donor bone marrow precursors of plasmacytoid dendritic cells (pre-pDC) can polarize...

    Unrelated Donor Allogeneic Hematopoietic Cell Transplant is Under-Utilized as a Curative Therapy in Eligible Patients from the United States

    Biology of Blood and Marrow Transplantation (Jun 2013)

    Background:

    Allogeneic hematopoietic cell transplant (alloHCT) is a curative therapy for hematologic disorders including acute lymphoblastic and myeloid leukemia (ALL/AML), chronic lymphocytic and myeloid leukemia (CLL/CML), Hodgkin and non-Hodgkin lymphoma (HL/NHL), multiple myeloma (MM) and myelodysplastic...

    Intermittent Zolendronic Acid Prevents Bone Loss in Adults after Allogeneic Hematopoietic Cell Transplantation

    Biology of Blood and Marrow Transplantation (Jun 2013)

    Bone mineral density (BMD) loss is common in survivors of allogeneic hematopoietic cell transplantation (alloHCT). We performed a multi center phase II randomized open label trial of intravenous zolendronic acid (ZA) to prevent BMD loss in adult recipients of alloHCT with osteopenia prior to HCT. The treatment group...

    Low levels of Interleukin-1 Receptor Antagonist (IL-1RA) predict for Engraftment Syndrome after autologous stem cell transplantation in POEMS Syndrome and other plasma cell neoplasms

    Biology of Blood and Marrow Transplantation (Jun 2013)

    A rare, multisystem plasma cell neoplasm, POEMS (polyradiculoneuropathy, organomegaly, endocrinopathy, M-spike, skin changes) syndrome is characterized by an abundance in pro-inflammatory and angiogenic cytokines. Patients with POEMS are known to have a high incidence of engraftment syndrome following autologous...

    The Expression of Th17 -Associated Cytokines in Human Acute Graft-versus-Host Disease

    Biology of Blood and Marrow Transplantation (Jun 2013)

    The role of Th17 cells and Th17-associated cytokines in the development of acute graft-versus-host disease (aGVHD) in clinical allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients is not well established. In the current study, a cohort of 69 allo-HSCT patients was examined for the percentages of...

    Fludarabine and 2 Gy TBI is Superior to 2 Gy TBI as Conditioning for HLA-Matched Related Hematopoietic Cell Transplantation: A Phase III Randomized Trial

    Biology of Blood and Marrow Transplantation (Jun 2013)

    The risk and benefit of adding fludarabine to a 2 Gy total body irradiation (TBI) nonmyeloablative regimen are unknown. For this reason, we conducted a prospective randomized trial comparing 2 Gy TBI alone or in combination with 90 mg/m2 fludarabine (FLU/TBI) before transplantation of peripheral blood stem cells...

    Temporal Changes in Plerixafor Administration and Hematopoietic Stem Cell Mobilization Efficacy: Results of a Prospective Clinical Trial in Multiple Myeloma

    Biology of Blood and Marrow Transplantation (Jun 2013)

    Plerixafor with granulocyte colony-stimulating factor (G-CSF) is effective for hematopoietic stem cell (HSC) mobilization in patients with non-Hodgkin Lymphoma and myeloma; however, labeling requires dosing 11 hours before apheresis. Pharmacodynamic studies show peak blood CD34+ cell counts at 10 to 14 hours;...

    Incidence of Supraventricular Arrhythmias during Autologous Peripheral Blood Stem Cell Transplantation

    Biology of Blood and Marrow Transplantation (Jun 2013)

    Arrhythmias, especially supraventricular arrhythmias, often complicate the clinical course during autologous hematopoietic cell transplantation (AHCT). We wanted to determine the incidence and risk factors for cardiac arrhythmias during AHCT. The study included 983 patients (median age, 58 years [range, 19 to 77];...

    Significance of Ethnicity in the Risk of Acute Graft-versus-Host Disease and Leukemia Relapse after Unrelated Donor Hematopoietic Stem Cell Transplantation

    Biology of Blood and Marrow Transplantation (Jun 2013)

    The significance of patient and donor ethnicity on risk of acute graft-versus-host disease (GVHD) and disease relapse after unrelated donor hematopoietic cell transplantation (HCT) is not known. A total of 4335 patient–donor pairs from the International Histocompatibility Working Group in HCT met the following 3...

    Impact of t(11;14)(q13;q32) on the Outcome of Autologous Hematopoietic Cell Transplantation in Multiple Myeloma

    Biology of Blood and Marrow Transplantation (Jun 2013)

    The t(11;14)(q13;q32) translocation is seen in 15%-20% patients with multiple myeloma (MM). It generally is not associated with worse outcomes. We studied the impact of t(11;14)(q13;q32) on outcome in patients with MM who received high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation...

    Birth order and transplant outcome in HLA-identical sibling stem cell transplantation – an analysis on behalf of the Center for International Blood and Marrow Transplantation (CIBMTR)

    Biology of Blood and Marrow Transplantation (Feb 2013)

    Background: Allogeneic stem cell transplantation is the most effective treatment option for many hematological malignancies, but graft-versus-host-disease (GvHD) remains a major cause of treatment failure. Besides well established risk factors for the outcome of transplantation, recent single-center studies have...

    Defining Incidence, Risk Factors, and Impact on Survival of Central Line-Associated Blood Stream Infections Following Hematopoietic Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome

    Biology of Blood and Marrow Transplantation (Feb 2013)

    Central line-associated blood stream infections (CLABSI) commonly complicate the care of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients following allogeneic stem cell transplantation (HCT). We developed a modified CLABSI (MCLABSI) definition which attempts to exclude pathogens usually acquired...

    Impact Of Pretransplant Conditioning Regimens On Outcomes Of Allogeneic Transplantation For Chemotherapy-Unresponsisve Diffuse Large B-Cell Lymphoma And Grade-Iii Follicular Lymphoma

    Biology of Blood and Marrow Transplantation (Feb 2013)

    Patients with chemorefractory non-Hodgkin lymphomas (NHL) generally have a poor prognosis. We used the observational database of the CIBMTR to study the outcome of 533 patients with refractory diffuse large B-cell lymphoma (DLBCL) or grade-III follicular lymphoma (FL-III) who underwent allogeneic transplantation...

    Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease

    Biology of Blood and Marrow Transplantation (Feb 2013)

    Pre-engraftment syndrome (PES) is poorly characterized and its clinical significance and the prognostic impact after unrelated cord blood transplantation (CBT) are unclear. To address these issues, we analyzed retrospectively the incidence, risk factors and clinical outcomes of PES in unrelated CBT recipients. Data of...

    CMV-specific cytotoxic T lymphocytes can be efficiently expanded from G-CSF mobilised haemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplant recipients

    Biology of Blood and Marrow Transplantation (Feb 2013)

    Uncontrolled cytomegalovirus (CMV) reactivation following allogeneic haemopoietic stem cell transplantation causes significant morbidity and mortality. Adoptive transfer of CMV-specific cytotoxic T lymphocytes (CTL) is a promising therapy to treat reactivation and prevent viral disease. In this study we describe the...

    Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia

    Biology of Blood and Marrow Transplantation (Feb 2013)

    We evaluated the outcome of children and adolescents with acquired severe aplastic anemia (SAA) who received haploidentical hematopoietic stem cell transplantation (HHCT) within vitro T cell-depleted peripheral blood stem cells. Twelve patients with acquired SAA received a total of 15 HHCTs within vitro CD3-depleted...

    Dynamic Change and Impact of Myeloid Derived Suppressor Cells in Allogeneic Bone Marrow Transplantation in Mice

    Biology of Blood and Marrow Transplantation (Feb 2013)

    Myeloid-derived suppressor cells (MDSCs) are a group of myeloid cells comprised of hematopoietic progenitor cells, immature macrophages, dendritic cells and granulocytes, which accumulate in inflammatory diseases and various cancers. Here, we investigated the dynamic changes and effects of MDSCs in graft-versus-host...

    Outcomes of related donor HLA-identical or HLA-haploidentical allogeneic blood or marrow transplantation for peripheral T-cell lymphoma

    Biology of Blood and Marrow Transplantation (Jan 2013)

    Background: The role of allogeneic blood or marrow transplantation (alloBMT) for peripheral T-cell lymphoma (PTCL) remains to be defined. There is growing interest in reduced-intensity conditioning (RIC) regimens and/or utilization of HLA-haploidentical (haplo) grafts given concerns about treatment-associated...

    Current practice in diagnosis and treatment of acute graft-versus-host disease – results from a survey among German-Austrian-Swiss HSCT centers

    Biology of Blood and Marrow Transplantation (Jan 2013)

    In order to assess current clinical practice in diagnosis and treatment of acute graft-versus-host disease (aGVHD) we performed a survey among German, Austrian and Swiss allogeneic hematopoietic stem cell transplant (alloHSCT) centers. Thirty-four (47%) of 72 contacted centers completed both the diagnostic and the...

    Folinic acid supplementation in higher doses is associated with graft rejection in pediatric hematopoietic stem cell transplantation

    Biology of Blood and Marrow Transplantation (Nov 2012)

    Folinic acid is widely used in hematopoietic stem cell transplantation (SCT), mainly to reverse antifolate effects of such drugs as methotrexate and cotrimoxazole, but also empirically to reduce toxicity and support hematopoietic recovery. However, concerns have been raised in oncohematology about reduced curative...

    Outcome of allogeneic peripheral blood stem cell transplantation by donor graft CD3+/Tregs ratio: a single centre experience

    Biology of Blood and Marrow Transplantation (Nov 2012)

    The therapeutic efficacy of allogeneic peripheral blood stem cell transplantation (PBSCT) for hematological malignancies relies largely on the graft-versus-leukemia (GVL) effects exerted by the donor CD3 cells, but there is a risk of onset of uncontrolled graft-versus-host disease (GVHD). T regs cells (CD4+CD25high...

    Autologous and allogeneic transplantation for burkitt lymphoma outcomes and changes in utilization: a report from the center for international blood and marrow transplant research

    Biology of Blood and Marrow Transplantation (Nov 2012)

    Trends in utilization and outcomes after autologous or allogeneic hematopoietic cell transplantation (HCT) for Burkitt Lymphoma (BL) were analyzed in 241 recipients reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) between 1985 and 2007. The autologous HCT cohort had a higher...

    Autologous stem cell transplantation: An effective salvage therapy in multiple myeloma

    Biology of Blood and Marrow Transplantation (Nov 2012)

    Eighty-one patients treated with high-dose therapy and autologous stem cell transplantion (ASCT) as part of salvage therapy after a frontline ASCT were included in a retrospective analysis. The median time between the first and the salvage ASCT was 47 months. Following salvage ASCT, 75 patients (93%) achieved at least...

    Updated experience with inolimomab as treatment for corticosteroid-refractory acute graft versus host disease

    Biology of Blood and Marrow Transplantation (Nov 2012)

    Refractory acute graft-versus-host disease (aGVHD) remains an important cause of mortality after allogeneic stem cell transplantation. No standard therapy exists once steroids fail to obtain a good response. In 2006 our group published a series of patients who received inolimomab, an anti–interleukin-2 receptor...

    The role of the mycobiome in human acute graft-versus-host disease

    Biology of Blood and Marrow Transplantation (Nov 2012)

    A role for gut bacteria in the pathogenesis of graft-versus-host disease (GVHD) has been firmly established; however, the role of Candida spp, which form part of the mycobiome, remains unknown. In a homogenous group of patients who underwent allogeneic stem cell transplantation (SCT), we found a significant impact of...

    Pilot Study of Comprehensive Geriatric Assessment (CGA) In Allogeneic Transplant: CGA Captures a High Prevalence of Vulnerabilities in Older Transplant Recipients

    Biology of Blood and Marrow Transplantation (Nov 2012)

    Comprehensive geriatric assessment (CGA) is frequently used in oncology to measure the health status of older adults with cancer, but it has not been studied in allogeneic hematopoietic cell transplantation (HCT). We conducted a prospective pilot study of CGA in allogeneic HCT recipients aged ≥50 years to examine the...

    Treosulfan-Thiotepa-Fludarabine based Conditioning Regimen for Allogeneic Transplantation in patients with Thalassaemia Major: A Single Centre Experience from North India

    Biology of Blood and Marrow Transplantation (Nov 2012)

    Hematopoietic stem cell transplantation (HSCT) is the definite treatment for thalassemia major. A busulfan (Bu) and cyclophosphamide (Cy)–based regimen has been the standard myeloablative chemotherapy, but is associated with higher treatment-related toxicity, particularly in patients classified as high risk by the...

    Biomaterials

    Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue

    Biomaterials (Oct 2011)

    In this study, the obtainment and characterization of decellularized rat tracheal grafts are described. The detergent-enzymatic method, already used to develop bioengineered pig and human trachea scaffolds, has been applied to rat tracheae in order to obtain airway grafts suitable to be used to improve our knowledge on...

    Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin-like growth factor binding protein 4 with elastin-like polypeptides

    Biomaterials (Oct 2011)

    The establishment of cardiomyocyte differentiation of embryonic stem cells (ESCs) is a useful strategy for cardiovascular regenerative medicine. Here, we report a strategy for cardiomyocyte differentiation of ESCs using substrate immobilization of insulin-like growth factor binding protein 4 (IGFBP4) with elastin-like...

    The use of BDNF to enhance the patency rate of small-diameter tissue-engineered blood vessels through stem cell homing mechanisms

    Biomaterials (Oct 2011)

    The patency rate of small-diameter tissue-engineered blood vessels is the determinant for their application in coronary artery bypass grafting. The coronary artery is innervated by vagus nerves. The origin of vagus nerves is rich in brain-derived neurotrophic factors (BDNF). We have investigated whether BDNF could...

    Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves

    Biomaterials (Oct 2011)

    Percutaneous heart valves are revolutionizing valve replacement surgery by offering a less invasive treatment option for high-risk patient populations who have previously been denied the traditional open chest procedure. Percutaneous valves need to be crimped to accommodate a small-diameter catheter during deployment,...

    The stimulation of an osteogenic response by classical monocyte activation.

    Biomaterials (Aug 2011)

    The monocyte/macrophage system plays a central role in host defense, wound healing and immune regulation at biomaterial surfaces. Monocytes can be classically and alternatively activated, and can be stimulated differently in response to variations in biomaterial surface properties. In this study, human monocytes,...

    Biophysical Chemistry

    Probing the efficacy of peptide-based inhibitors against acid- and zinc-promoted oligomerization of amyloid-β peptide via single-oligomer spectroscopy

    Biophysical Chemistry (Sep 2011)

    One avenue for prevention and treatment of Alzheimer's disease involves inhibiting the aggregation of amyloid-β peptide (Aβ). Given the deleterious effects reported for Aβ dimers and trimers, it is important to investigate inhibition of the earliest association steps. We have employed quantized photobleaching of...

    Bipolar Disorders

    A five–year follow–up study of neurocognitive functioning in bipolar disorder

    Bipolar Disorders (Jun 2014)

    Objectives:

    Cognitive dysfunction in bipolar disorder has been well–established in cross–sectional studies; however, there are few data regarding the longitudinal course of cognitive performance in bipolar disorder. The aim of this study was to examine the course of cognitive function in a sample...

    The impact of child sexual abuse on the course of bipolar disorder: a systematic review

    Bipolar Disorders (Jan 2013)

    Objectives: The aim of this review was to elucidate the impact of child sexual abuse on all clinical phenomena that occur after the onset of bipolar disorder, including associated clinical features that are not part of the diagnostic criteria for the disorder. Methods: Five databases were searched and supplemented with...

    Differences in resting corticolimbic functional connectivity in bipolar I euthymia

    Bipolar Disorders (Jan 2013)

    Objective: We examined resting state functional connectivity in the brain between key emotion regulation regions in bipolar I disorder to delineate differences in coupling from healthy subjects. Methods: Euthymic subjects with bipolar I disorder (n = 20) and matched healthy subjects (n = 20) participated in a resting...

    Birth

    The use of complementary and alternative medicine during pregnancy: a longitudinal study of Australian women.

    Birth (May 2011)

    Background: The use of complementary and alternative medicine is increasingly prevalent in contemporary Western societies. The objective of this study was to explore trends and patterns in complementary and alternative medicine practitioner consultations and the use of complementary and alternative medicine consumption...

    BJU International

    Preoperative Serum Albumin Is Associated With Mortality and Complications After Radical Cystectomy

    BJU International (Aug 2013)

    Objective:

    To determine the association between preoperative serum albumin and mortality and postoperative complications after radical cystectomy and urinary diversion.

    Patients and Methods:

    We conducted a retrospective review of 1097 radical cystectomies performed for the treatment of bladder...

    Oncological Outcomes after Robot-Assisted Radical Prostatectomy: Long Term Follow-up in 4,803 patients

    BJU International (Aug 2013)

    Objective:

    To evaluate oncologic outcomes in patients undergoing robot-assisted radical prostatectomy (RARP) at a high-volume tertiary center with focus on biochemical recurrence (BCR). Previous studies on oncologic outcomes for patients undergoing RARP for prostate cancer (PCa) are limited to small...

    Progression to detrusor muscle invasion during Urothelial carcinoma surveillance is associated with poor prognosis

    BJU International (Aug 2013)

    Objective:

    To evaluate survival in cystectomy patients who presented with non-muscle-invasive urothelial carcinoma and progressed to muscle invasion during surveillance. Our secondary objective was to evaluate the association between pre-cystectomy clinical factors and survival.

    Patients and...

    Urinary Tract Stone Raises Subsequent Risk for Urinary Tract Cancer: A Population-based Cohort Study

    BJU International (Aug 2013)

    Objectives:

    The results of epidemiologic studies about the relationship between urinary tract stone (UTS) and the development of urinary tract cancer (UTC) remain inconclusive. This study evaluated the association between UTS and UTC in Taiwanese patients.

    Subjects/Patients:

    We conducted a...

    Functional and oncological outcomeS of patients younger than 50 years treated with radical prostatectomy for localized prostate cancer in A European population

    BJU International (Aug 2013)

    Objectives:

    To addressed the biochemical and functional outcomes after radical prostatectomy (RP) of men <50 years of age in a large European population.

    Patients and Methods:

    Among 13268 patients who underwent RP for clinically localized prostate cancer (PCa) at our centre (1992-2011), 443 (3.3%)...

    Impact of smoking status and cumulative exposure on intravesical recurrence of upper tract urothelial carcinoma after radical nephroureterectomy

    BJU International (Aug 2013)

    Objectives:

    To assess the impact of cigarette smoking status, cumulative smoking exposure, and time from cessation on intravesical recurrence (IVR) outcomes in patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC).

    Patients and methods:

    A total of 519...

    Empiric antibiotics for an elevated prostate-specific antigen (PSA) level: a randomised, prospective, controlled multi-institutional trial

    BJU International (Jul 2013)

    Objective:

    • To determine the impact of empiric antibiotics on men with an elevated prostate-specific antigen (PSA) level.

    Subjects/Patients and Methods:

    • Men of any age with a PSA level of >2.5 ng/mL and normal digital rectal examination undergoing their first prostate biopsy were...

    Development of renal cell carcinoma (RCC) diagnostics and impact on prognosis

    BJU International (Jul 2013)

    Objective:

    • To evaluate imaging methods and prognoses between small renal cell carcinomas (RCCs) and larger tumours according to the era of diagnostics.

    Patients and Methods:

    • In all, 784 consecutive patients diagnosed with RCC between 1964 and 1997 at the Pirkanmaa Hospital District in...

    The association of preoperative serum albumin level and American Society of Anesthesiologists (ASA) score on early complications and survival of patients undergoing radical cystectomy for urothelial bladder cancer

    BJU International (Jul 2013)

    Objective:

    • To evaluate the impact of the preoperative American Society of Anesthesiologists (ASA) score and serum albumin level on complications, recurrences and survival rates of patients who underwent radical cystectomy (RC) for urothelial bladder cancer (UBC).

    Patients and Methods:

    Risk of in-hospital complications after radical cystectomy for urinary bladder carcinoma: population-based follow-up study of 7608 patients

    BJU International (Jul 2013)

    Objective:

    • To evaluate the risk of different in-hospital complications for patients undergoing a radical cystectomy (RC), as limited nationwide population data on short- and long-term complications after RC is available, despite it being the standard treatment for localised muscle-invasive urinary bladder...

    Predictive factors for worse pathological outcomes of upper tract urothelial carcinoma: experience from a nationwide high-volume centre in China

    BJU International (Jul 2013)

    Objectives:

    • To analyse the predictive factors for worse pathological outcome (muscle invasive pT2+, non-organ-confined pT3+ or N+ and histological Grade 3) of upper tract urothelial carcinoma (UTUC) in a Chinese population from a nationwide high-volume centre in China.

    Patients and...

    Examining long term outcomes of Bladder Exstrophy: A 20 year follow up

    BJU International (Jul 2013)

    Objective:

    Examine long term quality of life, urinary continence, and sexual function outcomes in patients with a diagnosis of bladder exstrophy (BE). Patients: 65 patients with BE and follow up for at least twenty years were identified

    Methods:

    The patients were identified and mailed study...

    Transcorporal artificial urinary sphincter implantation as a salvage surgical procedure for challenging cases of male SUI: surgical technique and functional outcomes in a contemporary series

    BJU International (Jul 2013)

    Objective:

    To describe the surgical technique of transcorporal AUS implantation and assess its efficacy on continence and erectile function.Patients and methods:

    A prospective evaluation was conducted between December 2007 and October 2012 in a tertiary reference center. All male patients treated by...

    “Adjustable Anchored Single Incision Mini Slings (SIMS-Ajust®) compared to Standard Mid-Urethral Slings (SMUS), Tension-free Vaginal Tapes (TVT-OTM); A health economic evaluation”

    BJU International (Jul 2013)

    Objectives:

    To assess the cost, quality of life (QoL) and cost-effectiveness of Single Incision Mini Slings (SIMS-Ajust®) compared to Standard Mid Urethral Slings (SMUS)- Tension-free Vaginal Tapes (TVT-OTM) in surgical management of female stress urinary incontinence (SUI).

    Patients and...

    Urinary Tract Abnormalities In Patients With Recurrent Urinary Tract Infections (UTI) After Hypospadias Repair

    BJU International (Jul 2013)

    Purpose:

    Hypospadias repair is commonly performed by pediatric urologists with established complications. Little is known about the development of recurrent UTIs in patients after hypospadias repair. Herein, we attempt to shed light on this poorly understood topic.

    Materials and Methods:

    We...

    Clinical Trial Risk in Castration Resistant Prostate Cancer: Immunotherapies Show Promise

    BJU International (Jun 2013)

    Objective: To determine the risk of failure during drug development in castration resistant prostate cancer (CRPC) and see what factors can improve outcomes. While several studies have performed similar methods for the industry as a whole, this is one of the first dealing exclusively with a single disease indication....

    Hereditary-like urothelial carcinomas of the upper urinary tract benefit more from adjuvant cisplatin-based chemotherapy after radical nephroureterectomy than sporadic tumors

    BJU International (Jun 2013)

    Objective: To evaluate the impact of the “hereditary-like” status in upper tract urothelial carcinoma (UTUC) on the survival of patients who have undergone radical nephroureterectomy (RNU) and adjuvant chemotherapy. Patients and methods: A multicenter retrospective study was performed on all patients with high-risk...

    Cost-effectiveness analysis of tension-free vaginal tape vs burch colposuspension for female stress urinary incontinence in the USA

    BJU International (Jun 2013)

    Objective: To compare the cost-effectiveness (CE) of tension-free vaginal tape (TVT) with that of burch colposuspension (BC) for the treatment of female stress urinary incontinence (SUI). Materials and Methods: A Markov-chain decision model was created to simulate treatment of SUI with TVT or BC using Treeage Pro...

    Recurrence and complications after transperineal bulboprostatic anastomosis for posterior urethral strictures resulting from pelvic fracture: a retrospective study from a urethral referral centre

    BJU International (Jun 2013)

    Objective: To describe the complications of transperineal end-to-end anastomotic urethroplasty in patients with posterior urethral strictures resulting from pelvic fracture. Materials and Methods: A total of 573 patients, who underwent bulboprostatic anastomosis for posterior urethral strictures, were enrolled in...

    No small slam: increasing incidents of genitourinary injury from toilets and toilet seats

    BJU International (Jun 2013)

    Objective: To describe the epidemiology of genitourinary (GU) injury from toilets that present to USA Emergency rooms (ERs). Materials and Methods: The National Electronic Injury Surveillance System (NEISS) is a stratified probability sample of hospital ER visits for USA consumer product-related injuries. NEISS was...

    Short-term patient reported health-related quality of life (HRQL) outcomes after robot-assisted radical cystectomy (RARC)

    BJU International (Jun 2013)

    Objective: To determine short-term health-related quality of life (HRQL) outcomes after robot-assisted radical cystectomy (RARC) using the Bladder Cancer Index (BCI) and European Organisation for Research and Treatment of Cancer (EORTC) Body Image Scale (BIS). Patients and Methods: All patients undergoing RARC were...

    Prospective evaluation of irrigation fluid absorption during pure transurethral bipolar plasma vaporisation of the prostate using expired-breath ethanol measurements

    BJU International (Jun 2013)

    Objectives: To investigate if absorption of irrigation fluid occurs during bipolar plasma vaporisation (BPV) of the prostate. To examine the clinical predictors of increased risk of fluid absorption and to assess if changes in serum electrolytes, venous pH, haemoglobin or haematocrit are able to detect intra-operative...

    Eligibility for Neoadjuvant/Adjuvant Cisplatin-Based Chemotherapy among Radical Cystectomy Patients

    BJU International (Jun 2013)

    Objective: To evaluate the serial changes in renal function by investigating various clinical factors after radical nephrectomy (RN). Patients and Methods: The study population consisted of 2068 consecutive patients who were treated at multiple institutions by RN for renal cortical tumor without metastasis between...

    Trends in renal function after radical nephrectomy: A multicenter analysis

    BJU International (Jun 2013)

    Objective: To evaluate the serial changes in renal function by investigating various clinical factors after radical nephrectomy (RN). Patients and Methods: The study population consisted of 2068 consecutive patients who were treated at multiple institutions by RN for renal cortical tumor without metastasis between...

    Benefit in Regionalization of Care for Patients Treated with Radical Cystectomy: A Nationwide inpatient Sample Analyses

    BJU International (Jun 2013)

    Objective: To quantify in absolute terms the potential benefit of regionalization of care from low- to high-volume hospitals. Materials and Methods: Patients with a primary diagnosis of bladder cancer treated with RC were identified within the Nationwide Inpatient Sample, a retrospective observational population-based...

    Paucity of evidence regarding urinary tract outcomes in closed spinal dysraphism: a systematic review.

    BJU International (Jun 2013)

    Objectives: To describe the long term upper and lower urinary tract outcomes in patients with closed spinal dysraphism. Closed spinal dysraphism (CSD) differs from open spinal dysraphism (OSD) by its long asymptomatic course and consequent later diagnosis. The outcome of upper and lower urinary tract function in adults...

    A cohort study of digoxin exposure and mortality in men with prostate cancer

    BJU International (Jun 2013)

    Objectives: To examine the association between digoxin exposure and mortality in men with prostate cancer using linked Irish national cancer registry and pharmacy claims data. Digoxin users were matched to non-users using a propensity score to identify men with similar cardiovascular comorbidity. Patients and Methods:...

    Nerve growth factor (NGF): a potential urinary biomarker for overactive bladder syndrome (OAB)?

    BJU International (Feb 2013)

    What's known on the subject? and What does the study add? The search for a biomarker in overactive bladder syndrome (OAB) is an emerging field of interest, as bladder dysfunction is a common complaint that causes significant morbidity. A biomarker may give us insight as a diagnostic tool, and also inform us about how...

    Lack of predictive correlation between peripheral arterial tone and colour flow Doppler parameters in men with erectile dysfunction

    BJU International (Feb 2013)

    Objective To evaluate whether peripheral arterial tone (PAT) can predict the results of penile colour flow Doppler in the evaluation of erectile dysfunction (ED). Patients and Methods Fifty men presenting to an ED clinic were tested with an Endo-PAT2000 machine (Itamar Medical, Caesarea, Israel), which assessed...

    Refractory chronic pelvic pain syndrome in men: can transcutaneous electrical nerve stimulation help?

    BJU International (Feb 2013)

    Objective: To evaluate the effect of transcutaneous electrical nerve stimulation (TENS) for treating men with refractory chronic pelvic pain syndrome (CPPS). Patients and Methods: A consecutive series of 60 men treated with TENS for refractory CPPS was evaluated prospectively at an academic tertiary referral centre....

    Antidiuretic effect of antimuscarinic agents in rat model depends on C-fibre afferent nerves in the bladder

    BJU International (Feb 2013)

    What's known on the subject? and What does the study add? Antichollnergic agents are anticipated to diminish storage symptoms, as well as nocturia. Nevertheless, the effect of this treatment on polyuria related to nocturia is not clear. By subgroup analysis of the data set from a phase III clinical trial of...

    Does obesity affect the accuracy of prostate-specific antigen (PSA) for predicting prostate cancer among men undergoing prostate biopsy

    BJU International (Feb 2013)

    What's known on the subject? and What does the study add? As most urologist known, obesity significantly lowers serum PSA levels. So there is some concern about delayed diagnosis of prostate cancer in obese men. In the present study, we found that the accuracy level of PSA for detecting prostate cancer was not...

    Urodynamic evaluation: can it prevent the need for surgical intervention in women with apparent pure stress urinary incontinence?

    BJU International (Feb 2013)

    Objectives: To identify how many patients with symptoms of pure stress urinary incontinence (SUI) do not require any surgical treatment on the basis of urodynamics (UDS) and how many patients still do not require surgery 1 year after UDS. To assess the outcomes of these patients at 12-month follow-up. Patients and...

    Tamm-Horsfall protein-associated nucleotides in patients with interstitial cystitis

    BJU International (Feb 2013)

    What's known on the subject? and What does the study add? The nucleotides associated with Tamm-Horsfall protein (THP) identified in this study are 2′(3′) isomers, which are uncommon and very little is known about their biochemical pathway and role in interstitial cystitis (IC). The current study provides additional...

    Predictors of the use of orthotopic bladder reconstruction after radical cystectomy for bladder cancer: data from a pilot study of 1756 cases 2004–2011

    BJU International (Feb 2013)

    What's known on the subject? and What does the study add? How often orthotopic reconstruction should be used after radical cystectomy is uncertain. Male sex, younger age, affluence, white ethnicity and treatment in specialist hospitals may be associated with more frequent use. More evidence about the level and likely...

    Pathological response to neoadjuvant chemotherapy for muscle-invasive micropapillary bladder cancer

    BJU International (Feb 2013)

    What's known on the subject? and What does the study add? Micropapillary bladder cancer is a high grade variant with poor prognosis. There is no consensus about patients with micropapillary bladder cancer receiving neoadjuvant chemotherapy, but many suggest that radical cystectomy should not be delayed. Data from this...

    Male circumcision decreases penile sensitivity as measured in a large cohort

    BJU International (Feb 2013)

    What's known on the subject? and What does the study add? The sensitivity of the foreskin and its importance in erogenous sensitivity is widely debated and controversial. This is part of the actual public debate on circumcision for non-medical reason. Today some studies on the effect of circumcision on sexual function...

    Clinical utility of the prostate cancer gene 3 (PCA3) urine assay in Japanese men undergoing prostate biopsy

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? It is known that a prostate cancer gene 3 (PCA3) urine assay is superior to serum PSA level or PSA-related indices for predicting a positive biopsy result in European and US men. This is the first report on PCA3 in a large cohort of Japanese men. The diagnostic...

    Significant variability in 10-year cumulative radiation exposure incurred on different surveillance regimens after surgery for pT1 renal cancers: yet another reason to standardize protocols?

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add?The topic of radiation safety has been hotly debated not only in the mainstream media, but also in the urological literature. Radiation exposure has been examined in urological diseases such as testicular cancer and urinary stone disease, with resultant...

    Differing risk of cancer death among patients with lymph node metastasis after radical prostatectomy and pelvic lymph node dissection: identification of risk categories according to number of positive nodes and Gleason score

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? Lymph node (LN) status is one of the most important prognostic variables in patients undergoing radical prostatectomy, but not all patients with node-positive PCa are at the same risk of recurrence and cancer-specific death. In this study we evaluated the role...

    Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non-metastatic carcinoma invading bladder muscle: results from a nationwide case–control study

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? Positive surgical margin (PSM) frequency after radical cystectomy has been estimated to be 4–15%. Studies that have not distinguished between the different sites of PSM have failed to show that they are an independent prognostic factor for disease-free survival....

    Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? Receipt of androgen deprivation therapy (ADT) has been associated with an increased risk of skeletal-associated complications, such as a decrease in bone mineral density and an increase in fracture risk. Many men with pre-existing health conditions receive ADT...

    A novel tool to assess the risk of urinary incontinence after nerve-sparing radical prostatectomy

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? Urinary incontinence is one of the most important morbidities after radical prostatectomy that has detrimental effect on the postoperative quality of life. The present study provides an accurate and dynamic multivariable risk stratification tool that predicts...

    Pathological and biochemical outcomes after radical prostatectomy in men with low-risk prostate cancer meeting the Prostate Cancer International: Active Surveillance criteria

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? Active surveillance has been widely accepted as a treatment tool for low-risk prostate cancer, and use of the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria can select smaller and less aggressive tumours in low-risk disease. The...

    Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? Family history (FH) is a major risk factor for the development of prostate cancer. The search for genetic variants has led to genome-wide association studies (GWAS), which have so far reported 47 susceptibility loci that predispose men to prostate cancer....

    Changes in serum prostate-specific antigen levels and the identification of prostate cancer in a large managed care population

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? The use of a single, elevated PSA level to screen for prostate cancer is controversial given its reported low specificity and the questionable benefits of PSA screening on prostate cancer mortality. Current guidelines in the USA recommend against screening using...

    Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? The use of MRI for prostate cancer diagnosis and staging is increasing. Indications for prostate MRI are not defined and many clinicians are unsure of how best to use MRI to aid clinical decisions. This evidence-based medicine article addresses the clinical...

    Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer?

    BJU International (Jan 2013)

    What's known on the subject? and What does the study add? Urothelial carcinoma of the bladder (UCB) is more prevalent in men than women; however, in women the tumour stage is generally more advanced at the time of the diagnosis and the prognosis is worse. Possible explanations include anatomical, genetic and...

    Local recurrence after retropubic radical prostatectomy for prostate cancer does not exclusively occur at the anastomotic site

    BJU International (Nov 2012)

    What's known on the subject? and What does the study add? Local recurrence after radical prostatectomy (RP) for clinically organ-confined prostate cancer is largely assumed to occur at the anastomotic site, as reflected in European and North American guidelines for adjuvant and salvage radiotherapy after RP. However,...

    Optimal strategy for penile rehabilitation after robot-assisted radical prostatectomy based on preoperative erectile function

    BJU International (Nov 2012)

    What's known on the subject? and What does the study add? Removing of prostate for the treatment of localized prostate cancer is associated with a variable loss of erectile function due to injury of the nerves of erection during operation. Some researchers have reported that after nerve-sparing radical prostatectomy...

    Early results of a European multicentre experience with a new self-anchoring adjustable transobturator system for treatment of stress urinary incontinence in men

    BJU International (Nov 2012)

    What's known on the subject? and What does the study add? Surgical treatment options for male stress urinary incontinence (SUI) include collagen injection, artificial urinary sphincter, or male sling placement. In recent years, various minimally invasive sling systems have been investigated as treatment options for...

    Treatment with curative intent and survival in men with high-risk prostate cancer. A population-based study of 11 380 men with serum PSA level 20–100 ng/mL

    BJU International (Jul 2012)

    What's known on the subject? and What does the study add? There are two randomized controlled trials showing that radiotherapy can be beneficial for men with locally advanced prostate cancer. The present study confirms the importance of curative treatment for men with high-risk prostate cancer. Objective: To...

    Blood Reviews

    Genetics of graft-versus-host disease: The major histocompatibility complex

    Blood Reviews (Nov 2012)

    Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but the best characterized genetic system is that of the human major histocompatibility complex (MHC) located on chromosome 6. Among the...

    BMC Family Practice

    General practitioners' and practice nurses' views and experience of managing depression in coronary heart disease: a qualitative interview study.

    BMC Family Practice (Jan 2012)

    Background: Depression is common in coronary heart disease (CHD). Affected patients have an increased incidence of coronary symptoms and death. Little is known about how best to manage primary care patients with both CHD and depression. This study is part of the UPBEAT-UK programme of research and was designed to...

    BMC Urology

    Efficacy of mirabegron in patients with and without prior antimuscarinic therapy for overactive bladder: a post hoc analysis of a randomized European-Australian Phase 3 trial

    BMC Urology (Sep 2013)

    Background:

    Antimuscarinic agents are currently the predominant treatment option for the clinical management of the symptoms of overactive bladder (OAB). However, low rates of persistence with these agents highlight the need for novel, effective and better-tolerated oral pharmacological agents. Mirabegron is a...

    Bone

    Modeling hepatic osteodystrophy in Abcb4 deficient mice

    Bone (May 2013)

    Hepatic osteodystrophy (HOD) denotes the alterations in bone morphology and metabolism frequently observed in patients with chronic liver diseases, in particular in case of cholestatic conditions. The molecular mechanisms underlying HOD are only partially understood. In the present study, we characterized the bone...

    Proposed pathogenesis for atypical femoral fractures: Lessons from materials research

    Bone (May 2013)

    Atypical femoral fractures (AFFs) have been well defined clinically and epidemiologically. Less clear are the underlying mechanisms responsible. This commentary points out the likely sources of decreased resistance to fracture using lessons from bone material studies and biomechanics. We hypothesize that the key...

    Cortical porosity in children is determined by age-dependent osteonal morphology

    Bone (May 2013)

    Introduction: Fracture rates in children are high. Cortical bone makes a major contribution to bone strength, determined by cortical geometry, mineralization and porosity. Of these, porosity remains least well explored. Since most cortical canals are part of an osteon, we examined osteons and their canals for...

    Nrp2 deficiency leads to trabecular bone loss and is accompanied by enhanced osteoclast and reduced osteoblast numbers

    Bone (May 2013)

    Neuropilin 1 (Nrp1) and Nrp2 are transmembrane receptors that can bind class 3 semaphorins (Sema3A-G) in addition to VEGF family members to play important roles in axonal guidance, vascularization and angiogenesis, as well as immune responses. Moreover, recent evidence implicates Sema3A/Nrp-mediated signaling in bone...

    MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix

    Bone (May 2013)

    Osterix (Osx) is an osteoblast-specific transcription factor that is essential for osteoblast differentiation and bone formation. Osx-null mice, which exhibit a complete absence of bone formation and arrested osteoblast differentiation, die immediately after birth. However, our understanding of the regulatory mechanism...

    Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification

    Bone (Jan 2013)

    The role of Wnt signaling is extensively studied in skeletal development and postnatal bone remodeling, mostly based on the genetic approaches of β-catenin manipulation. However, given their independent function, a requirement for β-catenin is not the same as that for Wnt. Here, we investigated the effect of Wnt...

    Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow

    Bone (Jan 2013)

    Long bone is an anatomically complicated tissue with trabecular-rich metaphyses at two ends and cortical-rich diaphysis at the center. The traditional flushing method isolates only mesenchymal progenitor cells from the central region of long bones and these cells are distant from the bone surface. We propose that...

    Osteocyte apoptosis

    Bone (Dec 2012)

    Apoptotic death of osteocytes was recognized over 15years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen...

    Krüppel-like factors KLF2 and 6 and Ki-67 are direct targets of zoledronic acid in MCF-7 cells

    Bone (Jan 2012)

    Bisphosphonates (BP) are used for the treatment of osteoporosis and bone metastases due to breast and prostate cancer. Recent clinical studies indicated a benefit in survival and tumor relapse with the supportive treatment of breast cancer using zoledronic acid (ZA), thus stimulating the debate about its putative...

    Independent predictors of all osteoporosis-related fractures among healthy Saudi postmenopausal women: The CEOR Study

    Bone (Jan 2012)

    This study was designed to identify independent predictors of all osteoporosis-related fractures (ORFs) among healthy Saudi postmenopausal women. We prospectively followed a cohort of 707 healthy postmenopausal women (mean age, 61.3±7.2years) for 5.2±1.3years. Data were collected on demographic characteristics, medical...

    Increased proportion of hypermineralized osteocyte lacunae in osteoporotic and osteoarthritic human trabecular bone: Implications for bone remodeling

    Bone (Dec 2011)

    Hypermineralized osteocyte lacunae (micropetrosis) have received little research attention. While they are a known aspect of the aging human skeleton, no data are available for pathological bone. In this study, intertrochanteric trabecular bone cores were obtained from patients at surgery for osteoporotic (OP) femoral...

    Brain and Development

    Clinical and ictal characteristics of infantile seizures: EEG correlation via long-term video EEG monitoring

    Brain and Development (Mar 2013)

    Purpose: The semiology of infantile seizures often shows different characteristics from that of adults. We performed this study to describe clinical and ictal characteristics of infantile seizures at less than two years of age. Methods: A retrospective study was done for infants with epilepsy (ages: 1–24months) who...

    Magnetoencephalography localizing spike sources of atypical benign partial epilepsy

    Brain and Development (Feb 2013)

    Rationale: Atypical benign partial epilepsy (ABPE) is characterized by centro-temporal electroencephalography (EEG) spikes, continuous spike and waves during sleep (CSWS), and multiple seizure types including epileptic negative myoclonus (ENM), but not tonic seizures. This study evaluated the localization of...

    Premonitory urges for tics in adult patients with Tourette syndrome

    Brain and Development (Jan 2013)

    Objective: Patients with Tourette syndrome (TS) often report characteristic sensory experiences, also called premonitory urges (PUs), which precede tic expression and have high diagnostic relevance. This study investigated the usefulness of a scale developed and validated in children and adolescents–the Premonitory...

    Partial seizures during ACTH therapy in a cryptogenic West syndrome patient

    Brain and Development (Jan 2013)

    Background: Partial seizures often develop during the clinical course of infantile spasms. Herein, we report a boy with cryptogenic West syndrome, who developed partial seizures that we suspected were induced by the ACTH therapy. Subject: The patient developed cryptogenic West syndrome at six months of age and ACTH...

    A case of neonatal human parechovirus encephalitis with a favourable outcome

    Brain and Development (Jan 2013)

    Human parechoviruses (HPeVs) are a new family of neurotropic viruses that cause central nervous system (CNS) infections similar to enterovirus (EVs) meningoencephalitis in the neonatal period, resulting in white matter lesions that can be visualized with cranial ultrasonography and magnetic resonance imaging, and...

    Mental healthcare efforts for the public after the Great East Japan Earthquake: “Guide to Good Mental Health for Those Affected by Natural Disasters” published by the Cabinet Office

    Brain and Development (Jan 2013)

    One year after the Great East Japan Earthquake, the Office of Policy for Suicide Prevention of the Cabinet Office published and distributed three stages of pamphlets under the supervision of the National Center of Neurology and Psychiatry, promoting understanding about mental healthcare for those affected by natural...

    Brain Research

    IGF-1 induces hypoxia-inducible factor 1α-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells

    Brain Research (Nov 2011)

    Glucose metabolism is essential for most mammalian neurons, and the passage of glucose across cell membranes is mainly facilitated by glucose transporter 3 (GLUT3). In ischemia/reperfusion injured brains, increase of IGF-1 secretion and GLUT3 up-regulation, are regarded as protective processes. Recent works have shown...

    High-frequency stimulation of the temporoammonic pathway induces input-specific long-term potentiation in subicular bursting cells

    Brain Research (Oct 2011)

    The subiculum (Sub) as a part of the hippocampal formation is thought to play a functional role in learning and memory. In addition to its major input from CA1 pyramidal cells, the subiculum receives input from the entorhinal cortex (EC) via the temporoammonic pathway. Thus far, synaptic plasticity in the subiculum was...

    Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression

    Brain Research (Sep 2011)

    Previous work showed that sleep deprivation (SD) impairs hippocampal-dependent cognitive function and synaptic plasticity, and a novel wake-promoting agent modafinil prevents SD-induced memory impairment in rat. However, the mechanisms by which modafinil prevented REM-SD-induced impairment of brain function remain...

    Breast

    Evaluations of aesthetic outcomes of oncoplastic surgery by surgeons of different gender and specialty: A prospective controlled study.

    Breast (May 2011)

    This prospective trial was designed to assess aesthetic outcomes of oncoplastic surgery. Standardized photographs were taken of 45 breast cancer patients undergoing oncoplastic surgery, preoperatively and 6 and 12 months postoperatively (oncoplastic group), and of 45 patients treated by conservative surgery without...

    British Journal of Dermatology

    A population–based study of the incidence of delusional infestation in Olmsted County, Minnesota, 1976–2010

    British Journal of Dermatology (May 2014)

    Background:

    Delusional infestation (DI) is a well–recognized clinical entity but there is a paucity of reliable data concerning its epidemiology. Knowledge of the epidemiology is fundamental to an understanding of any disease and its implications. Epidemiology is most accurately assessed using...

    Improvement of psoriasis during GLP–1 analogue therapy in type 2 diabetes is associated with decreasing dermal γδ T cells number: a prospective case series study

    British Journal of Dermatology (Feb 2014)

    Background:

    A few case reports suggest that incretin–based therapies could improve psoriasis in type 2 diabetic patients, the mechanism(s) of which remain unclear.

    Objective:

    To determine the effects after 16–20 weeks of a GLP–1 analogue on clinical severity and histopathological...

    Simvastatin as a novel therapeutic agent for venous ulcers: a randomized, double–blind, placebo–controlled trial

    British Journal of Dermatology (Feb 2014)

    Background:

    Although the standard treatment for venous ulcers is compression, drugs may be used as adjunctive therapy. Simvastatin has shown potential wound–healing properties, however, no studies have investigated its use for venous ulcers. This study assessed the efficacy and safety of simvastatin in...

    Efficacy of mycophenolate mofetil in severe mucocutaneous lichen planus: a retrospective review of 10 patients

    British Journal of Dermatology (Jun 2012)

    Background: Ulcerative lichen planus is an uncommon and severe subtype of lichen planus primarily affecting the oral mucosal surfaces. It may be associated with significant morbidity and often requires immunosuppressive therapy to achieve disease control. There have been no previous reports in which objective outcome...

    Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24

    British Journal of Dermatology (Jun 2012)

    Background: Psoriasis is a Th17/Th1-mediated skin disease that often responds to antitumour necrosis factor (TNF)-α therapies, such as etanercept. Objectives: To better define mechanisms by which etanercept improves psoriasis and to gain insight into disease pathogenesis. Methods: We investigated the early biochemical...

    The relevance of patch testing in peristomal dermatitis

    British Journal of Dermatology (Jun 2012)

    Background: Skin disorders are a common problem for ostomates, resulting in more than a third of visits to a stoma nurse. Irritant reactions, particularly irritant contact dermatitis, are the most frequently seen, accounting for > 50% of problems in some studies. Objectives: To report our experience in patch testing...

    Comparison of narrowband ultraviolet B exposure and oral vitamin D substitution on serum 25-hydroxyvitamin D concentration

    British Journal of Dermatology (Jun 2012)

    Background: A short course of narrowband ultraviolet B (NB-UVB) exposures increases the serum 25-hydroxyvitamin D [25(OH)D] concentration in patients with psoriasis and healthy subjects. Objectives: To compare the effects of NB-UVB and oral vitamin D substitution in healthy subjects in winter. Methods: Healthy adult...

    Methotrexate polyglutamates as a marker of patient compliance and clinical response in psoriasis: a single-centre prospective study

    British Journal of Dermatology (Jun 2012)

    Background: Methotrexate is activated by the sequential addition of glutamic acid residues to form methotrexate polyglutamates (MTXPG1–5). MTXPG1–5 inhibit enzymes of the folate–purine–pyrimidine pathways, and longer-chain MTXPG3–5 species are more active. Objectives: To determine the pattern of erythrocyte MTXPG1–5 in...

    Intralesional rituximab in the treatment of indolent primary cutaneous B-cell lymphomas: an epidemiological observational multicentre study. The Spanish Working Group on Cutaneous Lymphoma

    British Journal of Dermatology (Jun 2012)

    Background: Intravenous rituximab is a safe and effective option for the treatment of systemic non-Hodgkin B-cell lymphoma. The effectiveness of intralesional rituximab (ILR) in primary cutaneous B-cell lymphomas (PCBL) has been described in a small number of patients. Objectives: To evaluate the effectiveness,...

    Psoriasis: rationale for targeting IL-17

    British Journal of Dermatology (Jun 2012)

    The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin. The cytokine interleukin (IL)-17A plays a key role in host defence against extracellular bacteria and...

    Greying of the human hair. A worldwide survey, re-visiting the “50” rule of thumb.

    British Journal of Dermatology (Jun 2012)

    Background: While numerous papers have reported on the biological mechanisms of human hair pigmentation and greying, epidemiological descriptions of both natural hair colour and the greying process, worldwide, remain scarce. Objectives: To assess hair colour and greying in a large world sample of human subjects, and to...

    Study of oral, ear, nose and throat involvement in pemphigus vulgaris by endoscopic examination

    British Journal of Dermatology (Jun 2012)

    Background: Pemphigus vulgaris (PV) is an autoimmune blistering skin disorder characterized by the presence of suprabasal acantholysis and autoantibodies against desmoglein 3. There are two different clinical forms: mucocutaneous (MCPV) and mucosal (MPV). However, little is known about PV lesions in oral, ear, nose and...

    Direct primary closure without undermining in the repair of vermilionectomy defects of the lower lip

    British Journal of Dermatology (Jun 2012)

    Background: Vermilionectomy is an excisional technique for the treatment of lower lip squamous cell carcinoma and actinic cheilitis. The vermilionectomy defect is usually repaired by a labial mucosal advancement flap. Traditionally, the mucosal wound margins are widely undermined but this can be associated with...

    An educational programme for patients with psoriasis and atopic dermatitis: a prospective randomized controlled trial

    British Journal of Dermatology (Jun 2012)

    Background: Patient education in addition to standard treatment, with the aim of affecting care through courses, is a relatively new concept in dermatology. Here we introduce a randomized controlled trial (RCT) regarding a previously described 12-week educational programme for chronic skin diseases. Objectives: The...

    A randomized, half-side comparative study of aminolevulinate photodynamic therapy versus CO2 laser ablation in immunocompetent patients with multiple actinic keratoses

    British Journal of Dermatology (Jun 2012)

    Background: Photodynamic therapy (PDT) and laser ablation (LA) are frequently used treatment options for multiple actinic keratoses (AK), yet they have not been compared head to head. Objectives: To compare PDT and carbon dioxide (CO2) LA in the management of multiple AK using objective and subjective outcome measures....

    Successful treatment of moderate to severe plaque psoriasis with the PEGylated Fab′ certolizumab pegol: results of a phase II randomized, placebo-controlled trial with a re-treatment extension

    British Journal of Dermatology (Jun 2012)

    Background: Certolizumab pegol (CZP) is a PEGylated antitumour necrosis factor agent. Objectives: To evaluate the efficacy and safety of CZP in patients with plaque psoriasis. Methods: In a randomized, placebo-controlled, double-blind study, 176 patients with moderate to severe psoriasis received placebo or CZP 400 mg...

    Effect of biologic therapies targeting tumour necrosis factor-α on cutaneous mesenchymal stem cells in psoriasis

    British Journal of Dermatology (Jun 2012)

    Background: Psoriasis is a Th1 immune-mediated, inflammatory disease, in which skin lesions appear many years before the related metabolic and cardiovascular comorbidities, according to the theory of the ‘psoriatic march’. Inducible nitric oxide synthetase (iNOS), tumour necrosis factor (TNF)-α and vascular endothelial...

    Topical vitamin D3 analogues induce thymic stromal lymphopoietin and cathelicidin in psoriatic skin lesions

    British Journal of Dermatology (Jun 2012)

    Background: Psoriasis is a chronic inflammatory skin disease of unknown aetiology, and an active form of vitamin D3 (1α,25-dihydroxyvitamin D3) and its analogues (VD3As) are widely used topical reagents for psoriasis treatment. Besides their well-known calcium homeostasis functions, VD3As have been shown to have...

    Real-life experience of managing vulval erosive lichen planus: a case-based review and U.K. multicentre case note audit

    British Journal of Dermatology (Jun 2012)

    Background: There is a lack of published evidence for treatment and outcome measures for vulval erosive lichen planus (ELPV). Objectives: To conduct a multicentre case note review to examine real-life management of ELPV comparing current U.K. practice against an agreed audit standard. Methods: Criteria for standards of...

    The effect of systemic corticosteroid therapy on the expression of toll-like receptor 2 and toll-like receptor 4 in the cutaneous lesions of leprosy Type 1 reactions

    British Journal of Dermatology (Jun 2012)

    Background: Leprosy is complicated by immunological reactions which can occur before, during and after successful completion of multidrug therapy. Genetic studies have suggested that polymorphisms in toll-like receptors (TLRs) may affect the susceptibility of an individual with leprosy to developing Type 1 reactions....

    An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case–control study

    British Journal of Dermatology (Jun 2012)

    Background: Acne vulgaris is a disorder of the sebaceous follicles. Propionibacterium acnes can be involved in inflammatory acne. Objectives: This case–control study aimed at investigating the occurrence and localization of P. acnes in facial biopsies in acne and to characterize the P. acnes phylotype in skin...

    The south-east Scotland dermatology workload study: 30 years’ analysis

    British Journal of Dermatology (Jun 2012)

    Background: Dermatological activity data have been collected for the same region of south-east Scotland (population 1·24 million), approximately every 5 years, since 1981. This has allowed assessment of trends in demand from primary and secondary care, and activity within secondary care dermatology services, assisting...

    Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy

    British Journal of Dermatology (Jun 2012)

    Background: The field cancerization concept in photodamaged patients suggests that the entire sun-exposed surface of the skin has an increased risk for the development of (pre)-malignant lesions, mainly epithelial tumours. Topical photodynamic therapy (PDT) is a noninvasive therapeutic method for multiple actinic...

    The influence of treatments in daily clinical practice on the Children’s Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry

    British Journal of Dermatology (May 2012)

    Background: Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study. Objectives: To assess the Children’s Dermatology Life Quality Index (CDLQI) in a cohort of patients with...

    Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study

    British Journal of Dermatology (May 2012)

    Background: Imiquimod 5% cream can reduce or clear superficial and small nodular basal cell carcinoma (BCC). It could be used as a pretreatment of Mohs micrographic surgery (MMS) to decrease defect size. Objectives: To study if a pretreatment with imiquimod 5% cream decreases defect size after MMS. In addition, to...

    A new concept of a multidisciplinary lymphoedema centre: established in connection to a department of dermatology and the Copenhagen Wound Healing Center

    British Journal of Dermatology (May 2012)

    Background: Lymphoedema is increasingly recognized as a significant problem in healthcare. The number of patients is growing, posing a future challenge to healthcare systems and economics. Over the past decade, specialized lymphoedema management has been established around the world to accommodate the growing demands....

    Detection of a rare CDKN2A intronic mutation in a Hungarian melanoma-prone family and its role in splicing regulation

    British Journal of Dermatology (May 2012)

    Background: The major locus for melanoma predisposition is the cell cycle regulatory CDKN2A gene on chromosome 9p21. However, the frequency of germline coding mutations of the CDKN2A gene is lower than expected in melanoma-prone families linked to chromosome 9p21. Objectives: To investigate whether the rare IVS1+37 G/C...

    Epitopes, avidity and IgG subclasses of tyrosine hydroxylase autoantibodies in vitiligo and alopecia areata patients

    British Journal of Dermatology (May 2012)

    Background: We previously detected antibodies against tyrosine hydroxylase (TH) in 23% of patients with nonsegmental vitiligo and in 19% of patients with alopecia areata (AA). Objectives: To identify TH epitopes recognized by TH antibodies in patients with vitiligo and AA. Methods: Recombinant plasmids containing...

    Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology

    British Journal of Dermatology (May 2012)

    Background: AEC (ankyloblepharon–ectodermal defects–clefting) syndrome is an autosomal dominant ectodermal dysplasia disorder caused by mutations in the transcription factor p63. Clinically, the skin is dry and often fragile; other features can include partial eyelid fusion (ankyloblepharon), hypodontia, orofacial...

    The neuropeptide galanin is a novel inhibitor of human hair growth

    British Journal of Dermatology (May 2012)

    Background: Galanin is a trophic factor of the central and peripheral nervous system that shows widespread distribution in human skin. However, the exact localization and the role of galanin in the hair follicle (HF) remain to be clarified. Objectives: To characterize galanin expression in human scalp HFs and to...

    Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong

    British Journal of Dermatology (May 2012)

    Background: Allopurinol has been reported as a common cause of severe cutaneous adverse reactions (SCARs). Recent studies in various populations suggest that HLA-B*58:01 is a strong genetic marker for allopurinol-induced SCAR, especially in populations with a high frequency of HLA-B*58:01. Objectives: To confirm the...

    Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can)

    British Journal of Dermatology (Apr 2012)

    Background: Little is known about the associations of metabolic aberrations with malignant melanoma (MM) and nonmelanoma skin cancer (NMSC). Objectives: To assess the associations between metabolic factors (both individually and combined) and the risk of skin cancer in the large prospective Metabolic Syndrome and...

    British Journal of General Practice

    Identifying patients with suspected pancreatic cancer in primary care: derivation and validation of an algorithm

    British Journal of General Practice (Jan 2012)

    Background: Pancreatic cancer has the worst survival for any cancer and is often diagnosed late when the cancer is advanced. Chances of survival are more likely if patients can be diagnosed earlier. Aim: To derive and validate an algorithm to estimate absolute risk of having pancreatic cancer in patients with and...

    Evaluating the transferability of a hospital-based childhood obesity clinic to primary care: a randomised controlled trial

    British Journal of General Practice (Jan 2012)

    Background: The Care Of Childhood Obesity (COCO) clinic at the Bristol Royal Hospital for Children (BRHC) uses a multidisciplinary approach comprising a consultant, dietitian, and exercise specialist. The clinic has demonstrated efficacy in managing children's weight but similar clinics are scarce in the UK. Aim: This...

    British Journal of Haematology

    The mean fluorescence intensities of anti-HLA antibodies detected using micro-bead flow cytometry predict the risk of platelet transfusion refractoriness

    British Journal of Haematology (May 2013)

    There are no accepted methods to predict the development of platelet transfusion refractoriness (PTR) due to human leucocyte antigen (HLA)-alloimmunization. Hence, matched platelets are usually given only to patients demonstrating PTR, necessarily resulting in some ineffective random donor platelets (RDPLT)...

    A Phase I first-in-human study with tefinostat – a monocyte/macrophage targeted histone deacetylase inhibitor – in patients with advanced haematological malignancies

    British Journal of Haematology (May 2013)

    Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase inhibitor (HDACi). This first-in-human, standard 3 + 3 dose escalating trial of oral, once daily tefinostat was conducted to determine the safety, tolerability, pharmacokinetic and pharmacodynamic profile of tefinostat in relapsed/refractory...

    TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity

    British Journal of Haematology (May 2013)

    Multiple myeloma (MM) is an incurable neoplasm caused by proliferation of malignant plasma cells in the bone marrow (BM). MM is characterized frequently by a complete or partial deletion of chromosome 13q14, seen in more than 50% of patients at diagnosis. Within this deleted region the tripartite motif containing 13...

    The pan-histone deacetylase inhibitor CR2408 disrupts cell cycle progression, diminishes proliferation and causes apoptosis in multiple myeloma cells

    British Journal of Haematology (Dec 2011)

    In view of the fact that histone deacetylases (HDACs) are promising targets for myeloma therapy, we investigated the effects of the HDAC inhibitor CR2408 on multiple myeloma (MM) cells in vitro. CR2408 is a direct pan-HDAC inhibitor and inhibits all known 11 HDACs with a 50% inhibitory concentration (IC50) of 12 nmol/l...

    Clot lysis time and the risk of myocardial infarction and ischaemic stroke in young women; results from the RATIO case–control study

    British Journal of Haematology (Nov 2011)

    Reduced overall fibrinolytic capacity increases the risk of myocardial infarction (MI), as demonstrated in studies with predominantly male participants. We determined the influence of altered fibrinolysis on the risk of MI and ischaemic stroke (IS) in young women. The RATIO (Risk of Arterial Thrombosis In relation to...

    Platelet transfusions for patients with haematological malignancies: who needs them?

    British Journal of Haematology (May 2011)

    The goal of platelet transfusions is to prevent severe and life-threatening bleeding in patients with thrombocytopenia. This aim needs to be balanced against the risks associated with platelet transfusions as well as the challenge of maintaining an adequate supply. This review summarizes the recent evidence regarding...

    British Journal of Oral and Maxillofacial Surgery

    Recent advances in reconstructive oral and maxillofacial surgery

    British Journal of Oral and Maxillofacial Surgery (Dec 2011)

    Reconstruction within the head and neck is challenging. Defects can be anatomically complex and may already be compromised by scarring, inflammation, and infection. Tissue grafts and vascularised flaps (either pedicled or free) bring healthy tissue to a compromised wound for optimal healing and are the current gold...

    Comparison of sensory recovery at the subfascial and suprafascial donor sites of the free radial flap

    British Journal of Oral and Maxillofacial Surgery (Nov 2011)

    The radial flap may be raised using a subfascial or suprafascial approach. The latter donor site is associated with fewer healing complications. We retrospectively evaluated the quality of sensory recovery within two comparable groups of 30 patients with subfascial and suprafascial donor sites. When considering the two...

    British Journal of Surgery

    Impact of omission of surgery on survival of older patients with breast cancer

    British Journal of Surgery (Aug 2014)

    Background:

    Older patients with breast cancer are often not treated in accordance with guidelines. With the emergence of endocrine therapy, omission of surgery can be considered in some patients. The aim of this population–based study was to investigate time trends in surgical treatment between 1995 and...

    Risk of bleeding and adverse outcomes predicted by thromboelastography platelet mapping in patients taking clopidogrel within 7 days of non–cardiac surgery

    British Journal of Surgery (Aug 2014)

    Background:

    Patients often fail to stop clopidogrel appropriately before non–cardiac surgery. Thromboelastography platelet mapping (TEG–PM) can be used to measure the percentage adenosine 5′–diphosphate platelet receptor inhibition (ADP–PRI) by clopidogrel in these...

    Impact of postoperative non–steroidal anti–inflammatory drugs on adverse events after gastrointestinal surgery

    British Journal of Surgery (Aug 2014)

    Background:

    Recent evidence has suggested an association between postoperative non–steroidal anti–inflammatory drugs (NSAIDs) and increased operation–specific complications. This study aimed to determine the safety profile following gastrointestinal surgery across a multicentre setting in the...

    Surgical management of disappearing colorectal liver metastases

    British Journal of Surgery (Aug 2013)

    Background:

    Owing to expanded surgical indications for colorectal liver metastasis (CRLM) and improved systemic therapy, hepatic surgeons are increasingly faced with the problem of disappearing (no longer visible on imaging) liver metastasis (DLM).

    Methods:

    A review of relevant studies was...

    Modelling the cost-effectiveness of carotid endarterectomy for asymptomatic stenosis

    British Journal of Surgery (Nov 2012)

    Background: The aim of this study was to model the cost-effectiveness of carotid endarterectomy for asymptomatic stenosis versus medical therapy based on 10-year data from the Asymptomatic Carotid Surgery Trial (ACST). Methods: This was a cost–utility analysis based on clinical effectiveness data from the ACST with...

    Lymphadenectomy around the left renal vein in Siewert type II adenocarcinoma of the oesophagogastric junction

    British Journal of Surgery (Nov 2012)

    Background: The extent of lymphadenectomy in patients with Siewert type II adenocarcinoma of the oesophagogastric junction is controversial. The aim of this study was to investigate lymph node involvement around the left renal vein. Methods: Lymph node involvement and prognosis in patients with Siewert type II cancers...

    Recurrence pattern in patients with a pathologically complete response after neoadjuvant chemoradiotherapy and surgery for oesophageal cancer

    British Journal of Surgery (Nov 2012)

    Background: Little is known about recurrence patterns in patients with a pathologically complete response (pCR) or an incomplete response after neoadjuvant chemoradiotherapy (CRT) followed by resection for oesophageal cancer. This study was performed to determine the pattern of recurrence in patients with a pCR after...

    Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

    British Journal of Surgery (Nov 2012)

    Background: Clinical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap reconstruction in relation to complications and adjuvant...

    Impact of obesity on the cost of major colorectal surgery

    British Journal of Surgery (Nov 2012)

    Background: The incidence of obesity is increasing in New Zealand. The aim of the study was to determine whether obesity impacts on the cost of treating patients undergoing major colorectal surgery. Methods: Between 1 February 2008 and 31 July 2009, consecutive patients undergoing major colorectal surgery at...

    Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma

    British Journal of Surgery (Nov 2012)

    Background: Indications for preoperative biliary drainage (PBD) in the context of hepatectomy for hilar malignancies are still debated. The aim of this study was to investigate current European practice regarding biliary drainage before hepatectomy for Klatskin tumours. Methods:This was a retrospective analysis of all...

    Value of laparoscopy before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis

    British Journal of Surgery (Nov 2012)

    Background: The outcome of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) depends on the extent of peritoneal carcinomatosis. The role of laparoscopy in the preoperative assessment of extent of peritoneal carcinomatosis in potential candidates for cytoreductive surgery and HIPEC...

    Current practice of carotid endarterectomy in the UK

    British Journal of Surgery (Dec 2011)

    Background: Carotid endarterectomy (CEA) reduces the risk of stroke in patients with internal carotid stenosis of 50–99 per cent. This study assessed national surgical practice through audit of CEA procedures and outcomes. Methods: This was a prospective cohort study of UK surgeons performing CEA, using clinical audit...

    Associated injuries in casualties with traumatic lower extremity amputations caused by improvised explosive devices

    British Journal of Surgery (Dec 2011)

    Background: Improvised explosive devices (IEDs) pose a significant threat to military personnel, often resulting in lower extremity amputation and pelvic injury. Immediate management is haemorrhage control and debridement, which can involve lengthy surgery. Computed tomography is necessary to delineate the extent of...

    Prognostic significance of peritoneal washing cytology in patients with gastric cancer

    British Journal of Surgery (Nov 2011)

    Background: Positive peritoneal washing cytology is a poor prognostic factor in patients with gastric cancer. The right therapeutic approach for this condition has not been well documented. Methods: Patients who underwent surgery for gastric cancer with suspected serosal invasion and peritoneal washing cytology at the...

    Adhesions after laparoscopic and open ileal pouch–anal anastomosis surgery for ulcerative colitis

    British Journal of Surgery (Nov 2011)

    Background: Emerging evidence suggests that a laparoscopic approach to colorectal procedures generates fewer adhesions. Even though laparoscopic ileal pouch–anal anastomosis (IPAA) is a lengthy procedure, the prospect of fewer adhesions may justify this approach. The aim of this study was to assess abdominal and...

    Burns

    Comparison of pathogens and antibiotic resistance of burn patients in the burn ICU or in the common burn ward

    Burns (Aug 2013)

    Background:

    This study aims to compare pathogens and their antibiotic resistances of burn patients from burn intensive care unit (ICU) or common burn ward. Of 2395 clinical samples from 63 patients in burn ICU, pathogens were detected in 1621 samples, in which 1203 strains (74.2%) were Gram negative...

    Identification of predictors of early infection in acute burn patients

    Burns (May 2013)

    Burn patients are at high risk for infections; however, common indicators of infection are unreliable in this population and can lead to unnecessary use of antibiotics. The study objective was to determine if predictors of early infection in adult acute burn patients are identified to provide clinicians with a...

    The impact of oxandrolone on length of stay following major burn injury: A clinical practice evaluation

    Burns (May 2013)

    Introduction: The anabolic agent oxandrolone (OX) has been found to decrease length of stay (LOS) following 20–60% total body surface area (TBSA) burn injury. This study uses the Comprehensive Severity Index (CSI) to control for severity of illness and explores the relationship between OX and LOS in a more broadly...

    Epidemiology and mortality of burns in the Lucknow Region, India—A 5 year study

    Burns (May 2013)

    Nearly 95% of global burn deaths and disabilities are estimated to occur in low and middle income countries of the world. Burns are extremely common and are a major public health problem in a developing country like India. The purpose of this study was to record and evaluate the causes and the magnitude of the fatal...

    CA: A Cancer Journal for Clinicians

    Priorities for the primary prevention of breast cancer

    CA: A Cancer Journal for Clinicians (Mar 2014)

    Despite recent calls to intensify the search for new risk factors for breast cancer, acting on information that we already have could prevent thousands of cases each year. This article reviews breast cancer primary prevention strategies that are applicable to all women, discusses the underutilization of...

    Cancer screening in the United States, 2013

    CA: A Cancer Journal for Clinicians (Feb 2013)

    Each year the American Cancer Society (ACS) publishes a summary of its recommendations for early cancer detection, a report on data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, current ACS cancer screening guidelines are summarized, as are updated...

    Cancer statistics, 2013

    CA: A Cancer Journal for Clinicians (Jan 2013)

    Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, the Centers for Disease Control and...

    Calcified Tissue International

    Bone Mineral Density in Young Women on Methadone Substitution

    Calcified Tissue International (Sep 2011)

    Little is known about bone mineral density (BMD) in patients with heroin addiction and subsequent methadone substitution. The goal of this study was to compare bone mass density of young HIV-negative women on long-term methadone treatment to a local group of young healthy women. Eleven women (aged 20–29) with previous...

    Gastrointestinal Tolerability and Patterns of Switching in Patients Treated for Primary Osteoporosis: The Swedish Adherence Register Analysis (SARA)

    Calcified Tissue International (Sep 2011)

    The objective of this study was to describe and analyze the gastrointestinal tolerability and medication switching in patients receiving treatment for primary osteoporosis in Sweden. The study was based on all patients starting therapy with alendronate, risedronate, strontium ranelate, and raloxifene in Sweden between...

    Cancer

    Perioperative chemotherapy for muscle–invasive bladder cancer: A population–based outcomes study

    Cancer (Apr 2014)

    Background:

    Practice guidelines recommend neoadjuvant chemotherapy (NACT) for bladder cancer. However, the evidence in support of adjuvant chemotherapy (ACT) is less robust. Here we describe whether the evidence of efficacy for NACT/ACT was sufficient to change clinical practice and whether the efficacy...

    Presence of symptom clusters in surgically treated patients with esophageal cancer: Implications for survival

    Cancer (Nov 2013)

    Background:

    It is not known whether symptoms cluster together after esophageal cancer surgery or whether such symptom clusters are associated with survival in patients with esophageal cancer who are treated surgically.

    Methods:

    Data from a prospective Swedish nationwide cohort study of surgically...

    Managing body image difficulties of adult cancer patients: Lessons from available research

    Cancer (Nov 2013)

    Background:

    Body image is a critical psychosocial issue for patients with cancer because they often undergo significant changes to appearance and functioning. The primary purpose of this review article was to identify empirically–supported approaches to treat body image difficulties of adult cancer...

    Ethnic disparities in adherence to breast cancer survivorship surveillance care

    Cancer (Nov 2013)

    Background:

    Adherence to guidelines for surveillance mammography and clinic visits is an important component of breast cancer survivorship care. Identifying ethnic disparities in adherence may lead to improved care delivery and outcomes.

    Methods:

    Records were evaluated for 4535 patients who...

    No improvement noted in overall or cause–specific survival for men presenting with metastatic prostate cancer over a 20–year period

    Cancer (Nov 2013)

    Background:

    Prostate cancer mortality in the United States has declined by nearly 40% over the last 25 years. However, to the authors' knowledge, the contribution of prostate–specific antigen (PSA) screening for the early detection of prostate cancer remains unclear and controversial. In the current...

    Double–blind, randomized, phase 2 trial of maintenance sunitinib versus placebo after response to chemotherapy in patients with advanced urothelial carcinoma

    Cancer (Nov 2013)

    Background:

    Angiogenesis contributes to the progression of urothelial carcinoma (UC). In the current study, the authors investigated the role of maintenance sunitinib in patients with advanced UC.

    Methods:

    Patients with locally recurrent/metastatic UC and adequate organ function who achieved...

    HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia

    Cancer (Oct 2013)

    Background:

    Chronic myeloid leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single–;agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months.

    Methods:

    The outcome was analyzed for 42 patients with...

    The role of adjuvant radiotherapy in the local management of desmoplastic melanoma

    Cancer (Oct 2013)

    Background:

    In the current study, the authors sought to evaluate outcomes, specifically with respect to adjuvant radiotherapy (RT), for patients with desmoplastic melanoma.

    Methods:

    The records of 130 consecutive patients who presented between 1985 and 2009 with nonmetastatic desmoplastic melanoma...

    Development and validation of risk models and molecular diagnostics to permit personalized management of cancer

    Cancer (Oct 2013)

    Despite the advances made in cancer management over the past few decades, improvements in cancer diagnosis and prognosis are still poor, highlighting the need for individualized strategies. Toward this goal, risk prediction models and molecular diagnostic tools have been developed, tailoring each step of risk...

    Clinical characteristics and outcomes with specific BRAF and NRAS mutations in patients with metastatic melanoma

    Cancer (Sep 2013)

    Background::

    Hotspot mutations in BRAF and NRAS are the most common somatic events in patients with melanoma. These mutations occur at highly conserved residues, but include several different substitutions. To determine whether specific mutations are clinically important to differentiate,...

    Annual number of lung cancer deaths potentially avertable by screening in the United States

    Cancer (Feb 2013)

    Background: The National Lung Screening Trial (NLST), which was conducted between 2002 and 2009, demonstrated that screening with low-dose computed tomography (LDCT) reduced lung cancer mortality by 20% among screening-eligible populations compared with chest x-ray. In this article, the authors provide an estimate of...

    Patient-reported outcomes after 3-dimensional conformal, intensity-modulated, or proton beam radiotherapy for localized prostate cancer

    Cancer (Feb 2013)

    Background: Recent studies have suggested differing toxicity patterns for patients with prostate cancer who receive treatment with 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), or proton beam therapy (PBT). Methods: The authors reviewed patient-reported outcomes data collected...

    Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer

    Cancer (Feb 2013)

    Background: Increased pathologic complete response (pCR) rates observed with neoadjuvant chemotherapy (NCT) for some subsets of patients with invasive breast cancer have prompted interest in whether patients who achieved a pCR can be identified preoperatively and potentially spared the morbidity of surgery. The...

    RET/PTC and PAX8/PPARγ chromosomal rearrangements in post-Chernobyl thyroid cancer and their association with iodine-131 radiation dose and other characteristics

    Cancer (Feb 2013)

    Background: Childhood exposure to iodine-131 from the 1986 nuclear accident in Chernobyl, Ukraine, led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data concerning the association between genetic mutations in PTCs and individual radiation doses are limited....

    Birth rates among female cancer survivors

    Cancer (Feb 2013)

    Background: More women of fertile age are long-term survivors of cancer. However, population-based data on birth rates of female cancer survivors are rare. Methods: A total of 42,691 women ≤ 45 years with a history of cancer were identified from the Swedish Multi-Generation Register and the Swedish Cancer Register, for...

    Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States

    Cancer (Feb 2013)

    Background: Clinical trials in pediatric acute myeloid leukemia (AML) determine induction regimen standards. However, these studies lack the data necessary to evaluate mortality trends over time and differences in resource utilization between induction regimens. Moreover, these trials likely underreport the clinical...

    Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program

    Cancer (Feb 2013)

    Background: Nasopharyngeal carcinoma (NPC) is prevalent in Southeast Asia. Over the last decade, plasma Epstein-Barr virus (EBV) DNA has been developed as a tumor marker for NPC. In this study, the authors investigated whether plasma EBV DNA analysis is useful for NPC surveillance. Methods: In total, 1318 volunteers...

    Screening for distress in cancer patients

    Cancer (Feb 2013)

    Background: Routine screening for distress is internationally recommended as a necessary standard for good cancer care, given its high prevalence and negative consequences on quality of life. The objective of the current study was to contribute to the Italian validation of the Distress Thermometer (DT) to determine...

    Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis

    Cancer (Feb 2013)

    Background: Bone marrow (BM) biopsies from patients with chronic lymphocytic leukemia (CLL) may show reticulin fibrosis at diagnosis, but its significance remains unclear. This study sought to assess the prognostic impact of BM reticulin fibrosis in patients with previously untreated CLL. Methods: Data was reviewed...

    Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma

    Cancer (Feb 2013)

    Background: This study sought to determine if preoperative image-guided intensity-modulated radiotherapy (IG-IMRT) can reduce morbidity, including wound complications, by minimizing dose to uninvolved tissues in adults with lower extremity soft tissue sarcoma. Methods: The primary endpoint was the development of an...

    Modulation of c-Met signaling and cellular sensitivity to radiation

    Cancer (Feb 2013)

    The c-Met/hepatocyte growth factor receptor and its family members are known to promote cancer cell migration and invasion. Signaling within and beyond this pathway contributes to the systemic spread of metastases through induction of the epithelial-mesenchymal transition, a process also implicated in mediating...

    Synchronous cancers in patients with head and neck cancer

    Cancer (Feb 2013)

    Background: Second primary malignancies (SPMs) are the leading cause of death in survivors of head and neck squamous cell carcinoma (HNSCC). Synchronous SPMs are of significant clinical interest because they potentially can be identified by screening procedures at the time of diagnosis of the index cancer. Recently,...

    Coregistered whole body magnetic resonance imaging-positron emission tomography (MRI-PET) versus PET-computed tomography plus brain MRI in staging resectable lung cancer

    Cancer (Feb 2013)

    Background: The objective of this study was to assess whether coregistered whole brain (WB) magnetic resonance imaging-positron emission tomography (MRI-PET) would increase the number of correctly upstaged patients compared with WB PET-computed tomography (PET-CT) plus dedicated brain MRI in patients with nonsmall cell...

    Cancer Epidemiology

    Trends in incidence of breast cancer among women under 40 in seven European countries: A GRELL cooperative study

    Cancer Epidemiology (Jun 2013)

    Young women are not usually screened for breast cancer (BC). The trends in incidence in this population may better reflect changes in risk factors. However, studies on this subject are scarce and heterogeneous. The aim of this study was to describe the trends in incidence of BC in women under 40 from 1990 to 2008,...

    Cancer Genetics

    Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q)

    Cancer Genetics (Jan 2013)

    The isolated deletion of chromosome 20q [del(20q)] has been observed in both de novo and therapy-related cases of myelodysplastic syndrome (MDS). The clinicopathologic features of de novo MDS with isolated del(20q) are well characterized. However, relatively little is known about therapy-related myeloid neoplasms...

    A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer

    Cancer Genetics (Jan 2013)

    Since the identification of the TMPRSS2-ERG rearrangement as the most common fusion event in prostate cancer, various methods have been developed to detect this rearrangement and to study its prognostic significance. We report a novel four-color fluorescence in situ hybridization (FISH) assay that detects not only the...

    FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary

    Cancer Genetics (Oct 2011)

    Adult granulosa cell tumors (AGCTs) are a rare class of ovarian tumors with recurrent cytogenetic abnormalities including trisomy 12, trisomy 14, monosomy 16/deletion 16q, and monosomy 22. Over 90% contain a missense point mutation (C134W) in the FOXL2 gene at 3q22.3. The relationship between FOXL2 mutation and...

    Cancer Letters

    Differential effects of grape seed extract against human colorectal cancer cell lines: The intricate role of death receptors and mitochondria

    Cancer Letters (Jan 2013)

    Failure of anti-cancer therapy in colorectal cancer (CRC) cells involves resistance to death mechanisms. We investigated grape seed extract (GSE) ability to target CRC cells and delineated the mechanisms involved in GSE-induced CRC cell death. GSE selectively induced apoptotic death in human CRC cells; efficacy...

    Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma

    Cancer Letters (Jan 2013)

    Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor prognosis. Current standard treatment includes chemotherapy using DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. However, GBM patients exhibit various levels of the elevated expression of...

    Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B

    Cancer Letters (Jan 2013)

    Phytochemicals are well known to have cancer chemopreventive effects by induction of phase II detoxification enzymes including quinone reductase (NQO-1) and glutathione-S-transferases. These detoxification enzymes are commonly regulated by nuclear factor-E2 (Nrf2), which is a representative antioxidant and...

    Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma

    Cancer Letters (Jan 2013)

    Aldehyde dehydrogenase 1 (ALDH1) activity has now been employed successfully as a cancer stem cells (CSCs) marker in various tumors. We wanted to investigate whether ALDH1 can be used as a putative CSCs marker and a powerful prognostic factor in nasopharyngeal carcinoma (NPC). Here, we isolated ALDH1-positive cells...

    The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

    Cancer Letters (Jan 2013)

    In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in...

    Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover

    Cancer Letters (Jan 2013)

    Store-operated Ca2+ entry (SOCE) is a main Ca2+ influx pathway controlling the intracellular Ca2+ concentration in normal hepatocytes and hepatocellular carcinoma (HCC) cells. Ca2+ influx has been demonstrated to be involved in liver oncogenesis. Stromal interacting molecule (STIM) 1 acts as a sensor for the level of...

    Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis

    Cancer Letters (Jan 2013)

    The anti-tumor activity, metronomic chemotherapy sensitization potential and metastatic effects of the endogenous angiogenesis inhibitors thrombospondin-1 and PEDF were investigated in KM12 colon adenocarcinoma xenografts. Thrombospondin-1 and PEDF decreased KM12 tumor microvessel density, increased macrophage...

    Microvessel density and p53 mutations in advanced-stage epithelial ovarian cancer

    Cancer Letters (Jan 2013)

    We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was...

    Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

    Cancer Letters (Jul 2011)

    Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined...

    Genome-wide combination profiling of DNA copy number and methylation for deciphering biomarkers in non-small cell lung cancer patients

    Cancer Letters (Jun 2011)

    Early detection of lung cancer provides the highest potential for saving lives. To date, no routine screening method enabling early detection is available, which is a key factor in the disease's high mortality rate. Copy number changes and DNA methylation alterations are good indicators of carcinogenesis and cancer...

    Cancer Medicine

    The role of laser interstitial thermal therapy in enhancing progression–free survival of difficult–to–access high–grade gliomas: a multicenter study

    Cancer Medicine (May 2014)

    Surgical extent–of–resection has been shown to have an impact on high–grade glioma (HGG) outcomes; however, complete resection is rarely achievable in difficult–to–access (DTA) tumors. Controlled thermal damage to the tumor may have the same impact in DTA–HGGs. We report our...

    Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia

    Cancer Medicine (Feb 2014)

    Methylseleninic acid (MSeA) is a monomethylated selenium metabolite theoretically derived from subsequent β–lyase or transamination reactions of dietary Se–methylselenocysteine that has potent antitumor activity by inhibiting cell proliferation of several cancers. Our previous studies showed that...

    Evaluation of 5-year imatinib treatment of 458 patients with CP-CML in routine clinical practice and prognostic impact of different BCR-ABL cutoff levels

    Cancer Medicine (Feb 2013)

    We evaluated responses to the treatment and long-term outcomes of chronic myeloid leukemia patients treated with imatinib as first-line treatment in routine clinical setting from two countries with centralized tyrosine kinase inhibitors (TKIs) treatment. We assessed prognostic significance of European LeukemiaNet (ELN)...

    Cancer Treatment Reviews

    Determinants and associated factors influencing medication adherence and persistence to oral anticancer drugs: A systematic review

    Cancer Treatment Reviews (Feb 2013)

    Background and aims; The use of oral anticancer drugs has increased in modern oncology treatment. The move from intravenous treatments towards oral anticancer drugs has increased the patients’ own responsibility to take oral anticancer drugs as being prescribed. High rates of non-adherence to oral anticancer drugs have...

    Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities

    Cancer Treatment Reviews (Feb 2013)

    By the introduction of molecularly targeted anti-cancer drugs, that are designed to intervene with specific pathways aberrant in cancers with distinct mutations, the type of adverse events encountered has changed greatly compared to the adverse events profile of classical chemotherapeutic agents. Ocular toxicities,...

    Revisiting ovarian cancer preclinical models: Implications for a better management of the disease

    Cancer Treatment Reviews (Feb 2013)

    Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite progress in identifying “hallmark” genetic alterations associated with the main subtypes of epithelial ovarian cancer, the survival rate of women with EOC changed little since platinum-based treatment was introduced more than 30years...

    HER2-targeted therapy in breast cancer: A systematic review of neoadjuvant trials

    Cancer Treatment Reviews (Feb 2013)

    Targeting human epidermal growth factor receptor 2 (HER2) during or in sequence with chemotherapy improves overall survival in metastatic and early HER2-overexpressing breast cancer. In this paper we systematically review neoadjuvant clinical trial data in HER2-positive breast cancer and discuss key unanswered clinical...

    Targeted therapy in metastatic colorectal cancer – An example of personalised medicine in action

    Cancer Treatment Reviews (Feb 2013)

    In metastatic colorectal cancer (mCRC), an improved understanding of the underlying pathology and molecular biology has successfully merged with advances in diagnostic techniques and local/systemic therapies as well as improvements in the functioning of multidisciplinary teams, to enable tailored treatment regimens and...

    Merkel cell carcinoma from 2008 to 2012: Reaching a new level of understanding

    Cancer Treatment Reviews (Feb 2013)

    Merkel cell carcinoma (MCC) is a rare primary cutaneous carcinoma of the skin who has high aggressiveness, high risk of locoregional and distant spread, a mortality rate considerably higher than that of cutaneous melanoma and a poor survival. Its incidence has increased during the past twenty years. The studies...

    Developing a theoretical framework to illustrate associations among patient satisfaction, body image and quality of life for women undergoing breast reconstruction

    Cancer Treatment Reviews (Feb 2013)

    Within the field of breast reconstruction there is increasing focus on patient-reported outcomes related to satisfaction, body image, and quality of life. These outcomes are deemed highly relevant because the primary goal of breast reconstruction is to recreate the appearance of a breast (or breasts) that is satisfying...

    Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: Pharmacokinetic considerations and clinical implications

    Cancer Treatment Reviews (Feb 2013)

    Identification of the role of biological pathways in metastatic renal cell carcinoma (mRCC) has led to the development of targeted agents for its treatment, in particular those that inhibit the vascular endothelial growth factor pathway, and inhibitors of mammalian target of rapamycin (mTOR). mTOR is central to...

    Circulating tumor cells in colorectal cancer patients

    Cancer Treatment Reviews (Feb 2013)

    The availability of sensitive methods has allowed the detailed study of circulating tumor cells only recently. Evolving evidence support the prognostic and predictive role of these cells in patients affected by several solid tumors, including colorectal cancer. Ongoing studies are aimed at confirming that the molecular...

    A contemporary update on rates and management of toxicities of targeted therapies for metastatic renal cell carcinoma

    Cancer Treatment Reviews (Jan 2013)

    Background: To provide an updated review of adverse events associated with sunitinib, pazopanib, bevacizumab, temsirolimus, axitinib, everolimus and sorafenib and their management. Materials and methods: We performed a PubMed and Cochrane-based review of side effects associated with the seven agents including product...

    Targeting triple negative breast cancer: Is p53 the answer?

    Cancer Treatment Reviews (Jan 2013)

    Triple negative breast cancers, which are defined by lack of expression of estrogen, progesterone, or HER2 receptors, represent approximately 15% of all breast cancers, although they account for a much higher proportional of breast cancer mortality. This is due both to their innate aggressive biological...

    Cardiology in the Young

    Assessment of coronary ischaemia by myocardial perfusion dipyridamole stress technetium–99 m tetrofosmin, single–photon emission computed tomography, and coronary angiography in children with Kawasaki disease: pre– and post–coronary bypass grafting

    Cardiology in the Young (Aug 2014)

    Background:

    Coronary artery lesions in Kawasaki disease invasively assessed by coronary angiography. Evaluation of myocardial perfusion by single–photon emission computed tomography may identify the haemodynamic significance of coronary lesions.

    Objective:

    To evaluate diagnostic accuracy of...

    The prevalence of clinical features associated with primary ciliary dyskinesia in a heterotaxy population: results of a web–based survey

    Cardiology in the Young (Jun 2014)

    Primary ciliary dyskinesia and heterotaxy are rare but not mutually exclusive disorders, which result from cilia dysfunction. Heterotaxy occurs in at least 12.1% of primary ciliary dyskinesia patients, but the prevalence of primary ciliary dyskinesia within the heterotaxy population is unknown. We designed and...

    Use of triple ultra–high–pressure balloons for obstructed right ventricular outflow conduits in adults can be safe and effective

    Cardiology in the Young (Jun 2014)

    To date, no transcatheter valve has been approved for placement in the pulmonary position in Japan. Consequently, percutaneous balloon dilatation may be advised for stenotic right ventricular outflow lesions; however, technical difficulties persist, particularly in adults. We describe the acute haemodynamic changes...

    Cardiology Research and Practice

    Extravascular Lung Water and Acute Lung Injury

    Cardiology Research and Practice (Aug 2011)

    Acute lung injury carries a high burden of morbidity and mortality and is characterised by nonhydrostatic pulmonary oedema. The aim of this paper is to highlight the role of accurate quantification of extravascular lung water in diagnosis, management, and prognosis in “acute lung injury” and “acute respiratory distress...

    Cardiovascular Revascularization Medicine

    Anterior ECG changes following iatrogenic dissection of the right coronary artery into the aortic root: Exclusion of left coronary obstruction with transoesophageal echocardiography

    Cardiovascular Revascularization Medicine (Nov 2012)

    One of the most troublesome complications of percutaneous coronary intervention (PCI) or angiography is retrograde dissection of the artery into the aortic root. We report a case involving the right coronary artery (RCA) which was treated with prompt deployment of stents. Recurrent chest pain and ST segment elevation...

    The prognosis of periprocedural myocardial infarction after percutaneous coronary interventions

    Cardiovascular Revascularization Medicine (Nov 2012)

    An increase of biomarkers of myocardial necrosis is observed frequently after percutaneous coronary interventions (PCI) even when the procedure seems angiographically successful and otherwise uncomplicated. The recently updated Universal Definition of Myocardial infarction (MI) arbitrarily defined periprocedural MI...

    Cell Biochemistry and Biophysics

    Expression of HIWI in Human Hepatocellular Carcinoma

    Cell Biochemistry and Biophysics (Sep 2011)

    In this study, the investigation of the expression of HIWI and its protein in hepatocellular carcinoma (HCC) was performed, and the relationships between HIWI expression and the location of HCC metastases were analyzed. Sets of fresh HCC and matched adjacent normal hepatic tissue and paraffin-embedded tissue slides...

    Chest

    Overview to the Management of Cough: CHEST Guideline and Expert Panel Report

    Chest (Jul 2014)

    This overview will demonstrate that cough is a common and potentially expensive health care problem. Improvement in the quality of care of those with cough has been the focus of study for a variety of disciplines in medicine. The purpose of the Cough Guideline and Expert Panel is to synthesize current knowledge in a...

    CHEST Journal

    Characterization of First-Time Hospitalizations in Patients With Newly Diagnosed Pulmonary Arterial Hypertension in the REVEAL Registry

    CHEST Journal (Jun 2014)

    Background:

    Hospitalization is an important outcome in pulmonary arterial hypertension (PAH), shown previously to correlate with survival. Using the Registry to EValuate Early And Long–term PAH Disease Management (REVEAL), we sought to characterize first–time...

    A 16-year prospective study of community-onset bacteraemic Acinetobacter pneumonia: low mortality with appropriate initial empirical antibiotic protocols

    CHEST Journal (Jun 2014)

    Background:

    The genus Acinetobacter, well known as a nosocomial pathogen, can also cause severe community–onset pneumonia. Previous small case series suggest fulminant disease and a pooled hospital mortality of over 60%.

    Methods:

    We conducted a prospective observational study...

    Increased levels of osteopontin in sputum supernatant in COPD patients

    CHEST Journal (Jun 2014)

    Osteopontin (OPN) is a phosphorylated acidic glycoprotein that can function both as an extracellular matrix molecule and a cytokine. Recently published data support that OPN is up–regulated in surgical lung tissue samples of COPD patients.The aim of this study was to determine the levels of OPN in sputum...

    Clinical & Experimental Allergy

    Age-dependent sting recurrence and outcome in immunotherapy-treated children with anaphylaxis to Hymenoptera venom

    Clinical & Experimental Allergy (May 2013)

    Background: Data on outcome of insect venom immunotherapy in children are rare. Objective: We investigated the rate of sting recurrence and outcome of Hymenoptera venom anaphylaxis in children of different age groups treated with immunotherapy. Methods: Data from children consecutively referred for anaphylaxis to...

    Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2 on IgE-dependent secretion from human lung mast cells

    Clinical & Experimental Allergy (May 2013)

    Background: Prostaglandin E2 (PGE2) has been shown to inhibit IgE-dependent histamine release from human lung mast cells. This effect of PGE2 is believed to be mediated by EP2 receptors. However, definitive evidence that this is the case has been lacking in the absence of EP2-selective antagonists. Moreover, recent...

    Impaired macrophage phagocytosis in non-eosinophilic asthma

    Clinical & Experimental Allergy (Dec 2012)

    Background: Many patients with non-eosinophilic asthma have increased numbers of neutrophils in the airways. The explanation for this chronic inflammation remains unclear, but may result from an impaired ability of alveolar macrophages to phagocytose apoptotic cells (a process termed ‘efferocytosis’), as we have shown...

    Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial

    Clinical & Experimental Allergy (Dec 2012)

    Background: Obesity and asthma are associated conditions; however, the mechanisms linking the two remain unclear. Few studies have examined the effects of weight loss on inflammation and clinical outcomes in obese–asthma. Objective: To compare the effects of weight loss achieved by dietary restriction, exercise or...

    Heterogeneity in the responses of human lung mast cells to stem cell factor

    Clinical & Experimental Allergy (Dec 2012)

    Background: Stem cell factor (SCF) is a growth factor that is involved in mast cell differentiation and proliferation. SCF primes human lung mast cells for enhanced responses to IgE-directed activation but is not generally recognized as a direct activator. SCF mediates its effects through c-kit. Objective: The aim of...

    Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study

    Clinical & Experimental Allergy (Dec 2012)

    Background: Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age. Objective: To explore the effects of geohelminth infections and age on atopy,...

    Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test

    Clinical & Experimental Allergy (Dec 2012)

    Background: Strict avoidance is the only accepted management for cow's milk (CM) allergy. CM oral immunotherapy (CM-OIT) is under investigation. Objectives: To evaluate long-term safety of CM-OIT. To identify clinical/immunological predictors of adverse events. Methods: Prospective longitudinal epidemiological...

    Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection

    Clinical & Experimental Allergy (Dec 2012)

    Background: Modulation of the host immune response by helminths has been reported to be essential for parasite survival and also to benefit the host by suppressing inflammatory diseases such as allergies. We have previously shown that excretory-secretory products of Trichinella spiralis muscle larvae have...

    In silico prediction of Ara h 2 T cell epitopes in peanut-allergic children

    Clinical & Experimental Allergy (Dec 2012)

    Background: Despite the frequency and severity of peanut allergy, the only approved treatment is strict avoidance. Different types of immunotherapy with crude peanut extract are not universally effective and have been associated with relatively high adverse reaction rates. Objective: We sought to determine whether in...

    Peamaclein – A new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3

    Clinical & Experimental Allergy (Dec 2012)

    Background: Among the peach-derived allergens which are already known, the lipid transfer protein (Pru p 3) seems to be the one to exert severe allergic reactions. Objective: To identify and characterize a new peach allergen causing a clinical picture similar to that of Pru p 3. Methods: Patients were selected on the...

    Levels of prostaglandin E2 and Cysteinyl-leukotrienes in sputum supernatant of patients with asthma: The effect of smoking

    Clinical & Experimental Allergy (Dec 2012)

    Background: Smoking is associated with worse asthma outcomes and may modify airways inflammation. Such modification may be mediated through an effect on prostaglandin E2 (PGE2) and cysteinyl leukotrienes (Cyst-LTs). Objective: We aimed to determine the levels of both PGE2 and Cyst-LTs in sputum supernatants of patients...

    ALOX5 Polymorphism Associates with Increased Leukotriene Production and Reduced Lung Function and Asthma Control in Children with Poorly Controlled Asthma

    Clinical & Experimental Allergy (Dec 2012)

    Background: Identification of risk factors for reduced asthma control could improve the understanding and treatment of asthma. A promoter polymorphism in the 5-lipoxygenase gene affects gene expression and response to asthma therapy but its impact on disease control remains unclear. Objective: We sought to determine if...

    Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment

    Clinical & Experimental Allergy (Nov 2012)

    Background: Plasmacytoid dendritic cells (pDCs) infiltrate sites of acute Th2-dominant inflammation but their role in allergic asthma remains unclear. Objective: To characterise circulating pDCs from patients with allergic asthma outside their respective allergen season. Methods: Adhesion molecules, co-stimulatory...

    Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants

    Clinical & Experimental Allergy (Nov 2012)

    Background: Culture-dependent methods have shown that meconium, the newborn's first intestinal discharge, is not sterile, but the diversity of bacteria present in this material needs to be further characterized by means of more sensitive molecular techniques. Objective: Our aims were to characterize molecularly the...

    Hypersensitivity reactions to the Sabin vaccine in children with cow's milk allergy

    Clinical & Experimental Allergy (Nov 2012)

    Background: The Sabin vaccine is used worldwide, and most children with food allergies receive it without incident. However, in the 2009 vaccination campaign conducted in Argentina, four children experienced immediate-type hypersensitivity reactions following vaccination. Objective: We aimed to review the medical...

    Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility

    Clinical & Experimental Allergy (Nov 2012)

    Background: Genetic studies have identified numerous genes reproducibly associated with asthma, yet these studies have focused almost entirely on single nucleotide polymorphisms (SNPs), and virtually ignored another highly prevalent form of genetic variation: Copy Number Variants (CNVs). Objective: To survey the...

    Functional variants in the thromboxane A2 receptor gene are associated with lung function in childhood-onset asthma

    Clinical & Experimental Allergy (Nov 2012)

    Background: The thromboxane A2 receptor (TBXA2R) gene is associated with asthma, but no functional genetic variations are known to associate with the disease or its related phenotypes. Objective: To investigate the association of TBXA2R polymorphisms with asthma susceptibility and related phenotypes and to identify...

    Component resolved diagnosis of wasp (yellow jacket) venom allergy

    Clinical & Experimental Allergy (Nov 2012)

    Background: Wasp venom allergy is a potentially life-threatening condition with serious consequences of diagnostic error. Objective: To assess whether component resolved diagnosis, using non-glycosylated recombinant allergen components from yellow jacket can add to the diagnosis of wasp venom allergy. Methods: In total...

    Tropomyosin from tilapia (Oreochromis mossambicus) as an allergen

    Clinical & Experimental Allergy (Nov 2012)

    Background: Tilapia is among the most common fresh water fish species raised by fish farms and can cause allergic reactions upon ingestion. Objective: Investigate important allergens in Tilapia (Oreochromis mossambicus). Methods: Allergens were detected using immunoblotting. An important allergen was purified to...

    Benefits of progestin contraception in non-allergic angioedema

    Clinical & Experimental Allergy (Nov 2012)

    Background: Hereditary angioedema attacks can be induced or worsened by oral contraceptive containing estrogens. Objectives: The purpose of this study was to assess the impact of progestin contraceptives on angioedema attacks. Methods: We conducted a French retrospective, multicenter study of progestin contraception in...

    Genome-wide association study of body mass index in 23,000 individuals with and without asthma

    Clinical & Experimental Allergy (Nov 2012)

    Background: Both asthma and obesity are complex disorders that are influenced by environmental and genetic factors. Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co-morbidity between these conditions. Objective: To identify genetic variants that are...

    Non-Allergic, Mastocytosis Associated Rhinitis

    Clinical & Experimental Allergy (Nov 2012)

    Background: Systemic mastocytosis (SM) is a clonal proliferative disorder of mast cells (MC) that causes pathological accumulation of mast cells in various tissues, which results in clinical symptoms (e.g. diarrhoea, urticaria) due to MC mediator release. Previous studies have shown that up to fifty percent of rhinitis...

    Specific Patterns of Allergic Sensitization in Early Childhood and Asthma & Rhinitis Risk

    Clinical & Experimental Allergy (Nov 2012)

    Background: Specific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk. Objective: To define relationships among established sensitization to particular aeroallergens, quantitative analyses...

    Neonatal supplementation of processed supernatant from Lactobacillus rhamnosus GG improves allergic airway inflammation in mice later in life

    Clinical & Experimental Allergy (Oct 2012)

    Background: Oral supplementation with probiotic bacteria can protect against the development of allergic and inflammatory diseases. Objective: The aim of this study was to investigate potential immunomodulatory and allergy protective effects of processed Lactobacillus rhamnosus GG (LGG)-derived supernatants early in...

    Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood

    Clinical & Experimental Allergy (Oct 2012)

    Background: Epigenetic modifications may have a role in asthma susceptibility. Objective: To investigate whether epigenetic modification at birth of a CpG site necessary for regulation of IL-2 transcription (IL-2 Site1) is associated with the development of asthma during childhood. Methods: Methylation of IL-2 Site1...

    Value of the clinical history in the diagnosis of urticaria/angioedema induced by NSAIDs with cross-intolerance

    Clinical & Experimental Allergy (Sep 2012)

    Background: Multiple NSAID-induced urticaria/angioedema is the most common manifestation of hypersensitivity reactions to NSAIDs. Diagnostic evaluation is based on the clinical history and a drug provocation test. Objective: To evaluate the role of the clinical history in the diagnosis of multiple NSAID-induced...

    Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test

    Clinical & Experimental Allergy (Sep 2012)

    Background: Strict avoidance is the only accepted management for cow's milk (CM) allergy. CM oral immunotherapy (CM-OIT) is under investigation. Objectives: To evaluate long-term safety of CM-OIT. To identify clinical/immunological predictors of adverse events. Methods: Prospective longitudinal epidemiological...

    Mechanisms of Tolerance Induction in Allergic Disease: Integrating Current and Emerging Concepts

    Clinical & Experimental Allergy (Sep 2012)

    The prevalence of atopy and allergic disease continues to escalate worldwide. Defining immune mechanisms that suppress the underlying Th2-driven inflammatory processes is critical for the rational design of new treatments to prevent or attenuate disease. Allergen immunotherapy has provided a useful framework for...

    Nonhistaminergic Angioedema: Focus on Bradykinin-Mediated Angioedema

    Clinical & Experimental Allergy (Sep 2012)

    Angioedema is a result of increased vascular permeability, with subsequent extravasation of intravascular fluid into the surrounding tissues. Angioedema may be mediated by histamine, bradykinin, or other mediators. Histaminergic angioedema generally presents with urticaria and/or pruritus and will respond to...

    In silico prediction of Ara h 2 T cell epitopes in peanut allergic children

    Clinical & Experimental Allergy (Sep 2012)

    Background: Despite the frequency and severity of peanut allergy, the only approved treatment is strict avoidance. Different types of immunotherapy with crude peanut extract are not universally effective and have been associated with relatively high adverse reaction rates. Objective: We sought to determine whether in...

    Clinical & Experimental Immunology

    Dual role of IL-10 in the regulation of Respiratory Syncitial Virus (RSV)-induced lung inflammation

    Clinical & Experimental Immunology (Dec 2012)

    RSV lower respiratory tract infections (LRTI) are among the most common diseases necessitating hospital admission in children. In addition to causing acute respiratory failure, RSV infections are associated with sequelae such as secondary bacterial infections and reactive airway disease. One characteristic host...

    The effects of chemotherapeutic drugs on human monocyte-derived dendritic cell differentiation and antigen presentation

    Clinical & Experimental Immunology (Dec 2012)

    Recent studies indicate that chemotherapeutic agents may increase the anti-tumoral immune response. Based on the pivotal role of dendritic cells (DCs) in host tumour-specific immune responses, we investigated the effect of commonly used chemotherapeutic drugs Dexamethasone, Doxorubicin, Cisplatin and Irinotecan and...

    Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren's syndrome

    Clinical & Experimental Immunology (Dec 2012)

    Primary Sjögren's syndrome (pSS) is characterised by the presence of autoantibodies against the ribonucleoprotein (RNP) particles Ro/SSA and La/SS-B, and mononuclear cell infiltration of exocrine tissues, especially salivary and lachrymal glands. Low numbers of autoantigen-specific memory B cells and elevated levels of...

    Human Mesenchymal Stem Cells suppress donor CD4+ T cell proliferation and reduce pathology in a humanised mouse model of acute Graft versus Host Disease

    Clinical & Experimental Immunology (Dec 2012)

    Acute graft versus host disease (aGvHD) is a life threatening complication following allogeneic haematopoietic stem cell transplantation (HSCT), occurring in up to 30-50% of patients who receive HLA-matched sibling transplants. Current therapies for steroid refractory aGvHD are limited, with the prognosis of patients...

    Differential effect on cell-mediated immunity in human volunteers after intake of different lactobacilli

    Clinical & Experimental Immunology (Dec 2012)

    Probiotics are live microorganisms, which have beneficial effects on the host when ingested in adequate amounts. Probiotic bacteria may stimulate immune effector functions in a strain specific manner. In this blind placebo-controlled trial, we investigated the effects on the immune system following daily intake of six...

    Specific Antibody Deficiency in Children with Recurrent Respiratory Infections: a Controlled Study with Follow-Up

    Clinical & Experimental Immunology (Dec 2012)

    Results: Specific antibody deficiency (SAD) to unconjugated pneumococcal vaccine (PPV) is an established primary B cell immunodeficiency. The occurrence and natural history of SAD in children is unclear. Background: We conducted an observational study to identify SAD in children with recurrent respiratory infections....

    Promoting Transplantation Tolerance; Adoptive Treg Cell Therapy

    Clinical & Experimental Immunology (Dec 2012)

    Transplantation is a successful treatment for end-stage organ failure. Despite improvements in short term outcome, long-term survival remains suboptimal because of the morbidity and mortality associated with long term use of immunosuppression. There is, therefore, a pressing need to devise protocols that induce...

    Clinical & Experimental Ophthalmology

    Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature

    Clinical & Experimental Ophthalmology (Dec 2012)

    Background: Invasive fungal sinusitis is a rare condition that usually occurs in immuno-compromised patients and often presents as an orbital apex syndrome. It is frequently misdiagnosed on presentation and is almost always lethal without early treatment. Design: Retrospective case series of 14 consecutive patients...

    Efficacy and safety of collagen matrix implants in phacotrabeculectomy, and comparison with mitomycin C augmented phacotrabeculetcomy at one year

    Clinical & Experimental Ophthalmology (Dec 2012)

    Background: To assess the efficacy and safety of collagen matrix implant (Ologen TM) in phacotrabeculectomy surgeries in patients with primary glaucoma. Design: Prospective, non-randomized, comparative study. Participants: Sixty-six Asian patients undergoing phacotrabeculectomy. Methods: One eye of 33 consecutive...

    Is pre-operative ciliary body and iris anatomical configuration a predictor of malignant glaucoma development?

    Clinical & Experimental Ophthalmology (Dec 2012)

    Background: To investigate anatomic configuration of ciliary body and iris, using ultrasound biomicroscopy (UBM), as a predictive factor for development of malignant glaucoma (MG). Design: Retrospective study in a tertiary care hospital. Participants: Cohort of 31 consecutive patients diagnosed with postsurgical MG....

    Clinical and Developmental Immunology

    Are toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromes?

    Clinical and Developmental Immunology (Aug 2011)

    In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune...

    Lactococcus lactis NCC 2287 Alleviates Food Allergic Manifestations in Sensitized Mice by Reducing IL-13 Expression Specifically in the Ileum

    Clinical and Developmental Immunology (Jul 2011)

    Objective. Utilizing a food allergy murine model, we have investigated the intrinsic antiallergic potential of the Lactococcus lactis NCC 2287 strain. Methods. BALB/c mice were sensitized at weekly intervals with ovalbumin (OVA) plus cholera toxin (CT) by the oral route for 7 weeks. In this model, an oral challenge...

    Clinical Cardiology

    Physical Activity Behavior Two to Six Years Following Cardiac Rehabilitation: A Socioecological Analysis

    Clinical Cardiology (Dec 2012)

    Background: Cardiac rehabilitation (CR) promotes long-term positive health behaviours, such as physical activity (PA), in patients following a cardiovascular event. We have limited knowledge of long-term PA and its correlates. Therefore, this research examined both PA behaviour and socioecological correlates among...

    Clinical Colorectal ​Cancer

    Role of Conventional Chemosensitivity Test and Tissue Biomarker Expression in Predicting Response to Treatment of Peritoneal Carcinomatosis From Colon Cancer

    Clinical Colorectal ​Cancer (Jan 2013)

    Background: 5-Fluorouracil- or oxaliplatin-based regimens are the treatments of choice in patients with PC from colon cancer. There are currently no useful preclinical evaluations to guide the decision-making process for tailored therapy. The aim of the present study was to compare the advantages and limits of a...

    Comparison of Dietary and Lifestyle Habits Among Stage III and Metastatic Colorectal Cancer Patients: Findings from CALGB 89803 and CALGB 80405

    Clinical Colorectal ​Cancer (Jan 2013)

    Background: Cancer patients often pursue lifestyle and dietary changes with the aim to improve outcomes. Using data from 2 large National Cancer Institute-sponsored clinical trials, we report on the dietary and lifestyle practices of patients receiving therapy for stage III colon or metastatic colorectal cancer....

    Adenovirus-Mediated Transcriptional Targeting of Colorectal Cancer and Effects on Treatment-Resistant Hypoxic Cells

    Clinical Colorectal ​Cancer (Jan 2013)

    Background: Colorectal cancer is the second leading cause of cancer-related mortality and frequently presents with locally advanced or metastatic disease. Adenovirus (Ad) vectors are important gene delivery agents because they offer efficient and broad tissue transduceability. However, their ability to penetrate...

    Clinical Drug Investigation

    Medical Service Encounters and Payments Associated with Topical Adjunctive Therapy Use of Timolol for Glaucoma

    Clinical Drug Investigation (Nov 2012)

    Background: Topical [beta]-blockers are commonly prescribed for primary open-angle glaucoma. Existing research is limited regarding respiratory or cardiovascular events that may result from using these topical [beta]-blockers. Objective: To evaluate inpatient and outpatient service encounters and payments associated...

    Clinical Gastroenterology and Hepatology

    Association Between Reduced Plasma 25-hydroxy Vitamin D and Increased Risk of Cancer in Patients with Inflammatory Bowel Diseases

    Clinical Gastroenterology and Hepatology (Oct 2013)

    Background & Aims:

    Vitamin D deficiency is common among patients with inflammatory bowel diseases (IBD) (Crohn’s disease or ulcerative colitis). The effects of low plasma 25-hydroxy vitamin D (25[OH]D) on outcomes other than bone health are understudied in patients with IBD. We examined the association between...

    Efficacy and Safety of Treatment of Hepatitis C in Patients With Inflammatory Bowel Disease

    Clinical Gastroenterology and Hepatology (Jul 2013)

    Background & Aims:

    There is uncertainty about the efficacy and safety of treatment for hepatitis C virus (HCV) infection in patients with inflammatory bowel disease (IBD). IBD can become exacerbated during treatment with interferon (IFN), and serious adverse events, such as pancytopenia or hepatotoxicity, can...

    Long-Term Follow Up Reveals Low Incidence of Colorectal Cancer, but Frequent Need for Resection, Among Australian Patients with Inflammatory Bowel Disease

    Clinical Gastroenterology and Hepatology (May 2013)

    Background & Aims: Inflammatory bowel disease (IBD) can require surgical resection and also lead to colorectal cancer (CRC). We investigated the cumulative incidence of resection surgeries and CRC among patients with ulcerative colitis (UC) or Crohn’s disease (CD). Methods: We analyzed data from a cohort of patients...

    Dietary Cholesterol Intake is Associated with Progression of Liver Disease in Patients With Chronic Hepatitis C: Analysis of the HALT-C trial

    Clinical Gastroenterology and Hepatology (May 2013)

    Background: & Aims: Little is known about whether dietary cholesterol affects disease progression in patients with chronic hepatitis C virus (HCV) infection. Methods: We analyzed data from the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial, which included patients with advanced fibrosis and...

    Interpretation and Management of Hepatic Abnormalities in Pregnancy

    Clinical Gastroenterology and Hepatology (May 2013)

    The spectrum of liver disease in pregnancy includes liver disease unrelated to pregnancy, those that occur with increased frequency or severity in pregnancy and liver disease specific to pregnancy. Diseases of the liver unique to pregnancy reliably occur at specific points in the gestational spectrum. Thus, gestational...

    Cost-Effectiveness Analysis of Direct-Acting Antiviral Therapy for Treatment-Naïve Patients with Chronic Hepatitis C Genotype 1 Infection in the Veterans Health Administration

    Clinical Gastroenterology and Hepatology (May 2013)

    Background and Aim: The Veterans Health Administration (VHA) is the largest single provider of care for hepatitis C virus (HCV) infection in the US. We analyzed the cost-effectiveness of treatment with the HCV protease inhibitors boceprevir and telaprevir in a defined managed care population of 102,851 patients with...

    Cognitive Dysfunction is Associated with Poor Socio-Economic Status in Patients with Cirrhosis: an International Multi-Center Study

    Clinical Gastroenterology and Hepatology (May 2013)

    Background & Aims: In patients with cirrhosis, cognitive dysfunction most often results from covert hepatic encephalopathy (HE). These patients are not routinely tested for cognitive dysfunction, despite single-center evidence that it could be associated with poor socio-economic status (SES). We investigated the...

    Association Between Length of Barrett’s Esophagus and Risk of High-Grade Dysplasia or Adenocarcinoma in Patients Without Dysplasia

    Clinical Gastroenterology and Hepatology (May 2013)

    Background & Aims: It is not clear whether length of Barrett's esophagus (BE) is a risk factor for high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in patients with non-dysplastic BE (NDBE). We studied the risk of progression to HGD or EAC in patients with NDBE, based on segment length. Methods: We...

    Clinical Factors Associated with Development of Severe-Complicated Clostridium difficile Infection

    Clinical Gastroenterology and Hepatology (May 2013)

    Background & Aims: Clostridium difficile infection (CDI) can cause life-threatening complications. Severe complicated CDI is characterized by hypotension, shock, sepsis, ileus, megacolon, and colon perforation. We created a model to identify clinical factors associated with severe complicated CDI. Methods: We analyzed...

    Proton Pump Inhibitors Reduce the Risk of Neoplastic Progression in Patients with Barrett’s Esophagus

    Clinical Gastroenterology and Hepatology (Nov 2012)

    Background & Aims: Acid exposure contributes to the development of Barrett's esophagus (BE) and its progression toward esophageal adenocarcinoma. Patients with BE are frequently treated with acid suppressants, but it is unclear whether these prevent the development of BE-related cancer. We investigated therefore...

    Mutant TP53 in Duodenal Samples of Pancreatic Juice from Patients with Pancreatic Cancer or High-Grade Dysplasia

    Clinical Gastroenterology and Hepatology (Nov 2012)

    Background & Aims: Imaging tests can identify patients with pancreatic neoplastic cysts but not microscopic dysplasia. We investigated wither mutant TP53 can be detected in duodenal samples of secretin-stimulated pancreatic juice, and whether this assay can be used to screen for high-grade dysplasia and invasive...

    Placental Transfer of Anti-Tumor Necrosis Factor Agents in Pregnant Patients with Inflammatory Bowel Disease

    Clinical Gastroenterology and Hepatology (Nov 2012)

    Background & Aims: Some women with inflammatory bowel disease (IBD) require therapy with tumor necrosis factor (TNF) antagonists during pregnancy. It is not clear whether these drugs are transferred to the fetus, via the placenta, and then cleared, or whether structurally different TNF antagonists have different rates...

    Association between Sex Hormones and Colorectal Cancer Risk in Men and Women

    Clinical Gastroenterology and Hepatology (Nov 2012)

    Background & Aims: There is observational and clinical evidence that indicate that sex hormones affect development of colorectal cancer (CRC) in men and women. However, the relationship between endogenous sex hormone levels and CRC is unclear. Methods: We collected data on lifestyle, medical history, and diet etc....

    Albumin Infusion Improves Outcomes of Patients with Spontaneous Bacterial Peritonitis: A Meta-Analysis of Randomized Trials

    Clinical Gastroenterology and Hepatology (Nov 2012)

    Background & Aims: Renal impairment increases mortality among patients with spontaneous bacterial peritonitis (SBP), despite administration of non-nephrotoxic antibiotics. Albumin infusion has been reported to reduce renal impairment and mortality in patients with SBP. We performed a meta-analysis of randomized...

    Futility Rules for Telaprevir Combination Treatment for Patients with Hepatitis C Virus Infection

    Clinical Gastroenterology and Hepatology (Nov 2012)

    For patients treated with telaprevir, peginterferon, and ribavirin, futility rules have been developed to prevent needless drug exposure and minimize development of drug-resistant variants for patients who have little or no chance of achieving a sustained virologic response. We performed retrospective analyses of data...

    Clinical Genitourinary Cancer

    Perioperative Complications and Mortality After Radical Cystectomy When Using a Standardized Reporting Methodology

    Clinical Genitourinary Cancer (Jan 2013)

    Purpose: To evaluate, by using a standardized reporting methodology, the perioperative complications and mortality in patients who underwent radical cystectomy. Materials and Methods: We retrospectively reviewed all data of 404 consecutive patients who underwent radical cystectomy from 1995 to 2009 for nonmetastatic...

    Pooled Analysis of Phase II Trials Evaluating Weekly or Conventional Cisplatin as First-Line Therapy for Advanced Urothelial Carcinoma

    Clinical Genitourinary Cancer (Jan 2013)

    Background: Weekly gemcitabine with GC every 3-4 weeks is considered conventional first-line chemotherapy for advanced urothelial carcinoma (UC). Weekly split-dose cisplatin with wGC might be less toxic and have similar activity, but has not been compared with GC. We pooled published phase II trials of GC and wGC to...

    Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor

    Clinical Genitourinary Cancer (Jan 2013)

    Background: Our objective was to perform a long-term evaluation of conservative surgical treatment of Leydig cell tumors. Patients and Methods: A multicenter retrospective clinical study was performed at 6 European centers. Case files of all patients diagnosed with Leydig cell tumor and treated with conservative...

    Clinical Infectious Diseases

    The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America

    Clinical Infectious Diseases (Aug 2011)

    Evidenced-based guidelines for management of infants and children with community-acquired pneumonia (CAP) were prepared by an expert panel comprising clinicians and investigators representing community pediatrics, public health, and the pediatric specialties of critical care, emergency medicine, hospital medicine,...

    Clinical Lung Cancer

    The Effect of Radiotherapy Dose on Survival in Stage III Non-Small Cell Lung Cancer Patients undergoing Definitive Chemoradiotherapy

    Clinical Lung Cancer (Jun 2014)

    Background:

    This study examined trends in the radiotherapy dose prescribed and the impact of dose escalation on survival in patients with stage III lung cancer.

    Methods:

    Radiation dose prescription patterns were analyzed for 38,848 patients in the National Cancer Database with clinical stage III...

    ALK inhibitors: What is the best way to treat patients with ALK–positive NSCLC?

    Clinical Lung Cancer (Jun 2014)

    Genetic insight into the pathogenesis of lung cancer has paved the way for a new era in the treatment of lung cancer. Recently, ALK has been identified to exert a potent transforming effect via genetic rearrangement in patients with lung cancer. Pre–clinical and single–arm phase I studies have...

    Clinical Lymphoma Myeloma and Leukemia

    Rituximab Maintenance Therapy Until Progression After Rituximab and Chemotherapy Induction in Patients With Follicular Lymphoma

    Clinical Lymphoma Myeloma and Leukemia (Jan 2013)

    Introduction The PRIMA (Primary Rituximab and Maintenance) study established 2 years of maintenance rituximab (MR) as a standard of care for follicular lymphoma (FL) patients who achieve an objective response after induction chemotherapy. A 17% improvement in progression-free survival (PFS) compared with those who did...

    Clinical Microbiology and Infection

    Clinical Characteristics Of Relaspes And Reinfections In Clostridium Difficile Infection

    Clinical Microbiology and Infection (Jun 2014)

    Clostridium difficile infection (CDI) is a common healthcare–associated infection with a recurrence rate of up to 36% among initially treated patients [1]. Age over 65 years, severe underlying disease, use of antibiotics for non–CDI infections or proton pump inhibitor and prior hospital...

    The Clostridium difficile PCR ribotype 027 lineage: a pathogen on the move

    Clinical Microbiology and Infection (Apr 2014)

    Clostridium difficile is a Gram–positive, spore–forming, human and animal pathogen that is the major cause of antibiotic–associated diarrhoea worldwide. The past decade has seen the rapid emergence of the hypervirulent PCR ribotype (RT) 027 complex, which has been associated with...

    Predicting a complicated course of Clostridium difficile infection at the bedside

    Clinical Microbiology and Infection (Sep 2013)

    Clostridium difficile infections (CDI) are a common cause of antibiotic associated diarrhea and associated with CDI-related mortality in approximately 10%. To date, there is no prediction model in use that guides clinicians to identify patients at high risk for complicated CDI.

    From 2006 to 2009, nine...

    Tumor necrosis factor alpha antagonist drugs and leishmaniasis in Europe

    Clinical Microbiology and Infection (Oct 2012)

    Leishmaniasis is endemic in Europe and the prevalence of latent infection in the Mediterranean region is high. Reports describing opportunistic leishmaniasis in European patients treated with tumor necrosis factor (TNF) alpha antagonist drugs are rapidly accumulating. For other granulomatous infections, risk of...

    Methicillin-susceptible Staphylococcus aureus clone related to the early pandemic phage type 80/81 causing an outbreak among residents of three occupational centres in Barcelona, Spain

    Clinical Microbiology and Infection (Oct 2012)

    In the 1950s an unusually virulent and transmissible penicillin-resistant Staphylococcus aureus clone harbouring Panton–Valentine leukocidin (PVL) genes, known as phage type 80/81 and subsequently identified as multilocus sequence type (ST) 30, emerged and caused serious infections in hospitals and the community. We...

    Emergence of MRSA of unknown origin in the Netherlands

    Clinical Microbiology and Infection (Oct 2012)

    The Netherlands is known for its low methicillin-resistant Staphylococcus aureus (MRSA) prevalence. Yet MRSA with no link to established Dutch risk factors for acquisition, MRSA of unknown origin (MUO), has now emerged and hampers early detection and control by active screening upon hospital admittance. We assessed the...

    Acute toxoplasmoses in immunocompetent patients hospitalized in an intensive care unit in French Guiana

    Clinical Microbiology and Infection (Sep 2012)

    Atypical Toxoplasma gondii strains, unrelated to archetypal clonal lineages (I, II, III), have been reported more frequently over the last decade in areas other than Europe and North America. A newly described form of toxoplasmosis, ‘Amazonian toxoplasmosis’ (AT), has been reported since 2002 in French Guiana. It is...

    Borrelia hispanica in Ornithodoros erraticus, Portugal

    Clinical Microbiology and Infection (Aug 2012)

    Tick-borne relapsing fever (TBRF) is a spirochetal infection caused by the genus Borrelia. The disease is distributed in the Old and New World with many different species reported. In Europe, TBRF is caused by B. hispanica transmitted to man by Ornithodoros erraticus, a soft tick usually found in old premises to...

    Invasive group A streptococcal infections in adults, France (2006–2010)

    Clinical Microbiology and Infection (Aug 2012)

    Severe invasive group A streptococcal diseases have re-emerged during the past 10–20 years. In order to provide a better insight into the current epidemiological situation in France, we analysed the questionnaires regarding all invasive strains received at the National Reference Center for Streptococci (CNR-Strep)...

    Antimicrobial treatment of invasive non-perinatal human listeriosis and the impact of the underlying disease on prognosis

    Clinical Microbiology and Infection (Aug 2012)

    Listeriosis is a resurgent foodborne disease in European countries. Benefits of combined β-lactam-aminoglycoside treatment remain controversial and the impact of the underlying disease on prognosis has not been fully assessed. We conducted a retrospective review of cases of sporadic listeriosis in adults from 1995 to...

    Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents

    Clinical Microbiology and Infection (Aug 2012)

    The measurement of early bactericidal activity (EBA) is the first step in the clinical investigation of antituberculosis agents. EBA is determined by quantifying the viable sputum mycobacterial load on consecutive days of treatment. To investigate whether time to positivity (TTP) in mycobacterial liquid culture can...

    The undiagnosed cases of Clostridium difficile infection in a whole nation: where is the problem?

    Clinical Microbiology and Infection (May 2012)

    Underdiagnosis of Clostridium difficile infection (CDI) because of lack of clinical suspicion or the use of non-sensitive diagnostic techniques is a known problem whose real magnitude has not yet been quantified. In order to estimate the extent of this underdiagnosis, we performed C. difficile cultures on all unformed...

    Smartphone apps in microbiology—is better regulation required?

    Clinical Microbiology and Infection (May 2012)

    Increasing diversity of available medical applications (apps) has led to their widespread use in healthcare delivery. However, app involvement in diagnosis and patient management has raised concerns, specifically regarding accuracy and reliability of content. Here, we report on the contemporary range of...

    Methicillin-resistant Staphylococcus aureus among companion and food-chain animals: impact of human contacts

    Clinical Microbiology and Infection (May 2012)

    Methicillin-resistant Staphylococcus aureus (MRSA), one of the major pathogens in humans, is a cause of infection and colonization among animals. The increasing number of companion animals and antibiotic use have made this population a reservoir of MRSA. In parallel, the evolution of new MRSA clones and mec homologues...

    Clostridium difficile infection in the community: a zoonotic disease?

    Clinical Microbiology and Infection (Apr 2012)

    Clostridium difficile infections (CDIs) are traditionally seen in elderly and hospitalized patients who have used antibiotic therapy. In the community, CDIs requiring a visit to a general practitioner are increasingly occurring among young and relatively healthy individuals without known predisposing factors. C....

    Extended-spectrum β-lactamase-producing and AmpC-producing Escherichia coli from livestock and companion animals, and their putative impact on public health: a global perspective

    Clinical Microbiology and Infection (Apr 2012)

    The possible zoonotic spread of antimicrobial-resistant bacteria is controversial. This review discusses global molecular epidemiological data combining both analyses of the chromosomal background, using multilocus sequence typing (MLST), and analyses of plasmid (episomal) extended-spectrum β-lactamase (ESBL)/AmpC...

    Enterococci of animal origin and their significance for public health

    Clinical Microbiology and Infection (Apr 2012)

    Enterococci are commensal bacteria in the intestines of humans and animals, but also cause infections in humans. Most often, Enterococcus faecium isolates from clinical outbreaks belong to different types than E. faecium from animals, food, and humans in the community. The same variants of the vanA gene cluster...

    First detection of VIM-4 metallo-β-lactamase-producing Escherichia coli in Russia

    Clinical Microbiology and Infection (Apr 2012)

    An Escherichia coli isolate co-producing VIM-4 metallo-β-lactamase and CTX-M-15 extended spectrum β-lactamase was recovered from the urine of a patient with head trauma in Moscow, Russia. The blaVIM-4 and blaCTX-M-15 genes were carried, respectively, by transmissible plasmids of IncW and IncI1 groups. The nucleotide...

    Anidulafungin for the treatment of candidaemia/invasive candidiasis in selected critically ill patients

    Clinical Microbiology and Infection (Mar 2012)

    A prospective, multicentre, phase IIIb study with an exploratory, open-label design was conducted to evaluate efficacy and safety of anidulafungin for the treatment of candidaemia/invasive candidiasis (C/IC) in specific ICU patient populations. Adult ICU patients with confirmed C/IC meeting ≥1 of the following criteria...

    Clinical Neurology and Neurosurgery

    Current management and surgical outcomes of medically intractable epilepsy

    Clinical Neurology and Neurosurgery (Oct 2013)

    Epilepsy is one of the most common neurologic disorders in the world. While anti–;epileptic drugs (AEDs) are the mainstay of treatment in most cases, as many as one–;third of patients will have a refractory form of disease indicating the need for a neurosurgical evaluation. Ever since the first half of...

    Newly diagnosed multiple sclerosis in state of Qatar

    Clinical Neurology and Neurosurgery (Feb 2013)

    Background: Epidemiologic studies on multiple sclerosis (MS) are well-documented in the western population but to a lesser extent in Arab world. Objective: To study the demographics, clinical aspects, radiologic and laboratory features along with the degree of disability inflicted, and factors affecting disease...

    Subacute peripheral and optic neuropathy syndrome with no evidence of a toxic or nutritional cause

    Clinical Neurology and Neurosurgery (Feb 2013)

    Background: The syndrome of subacute simultaneous peripheral neuropathy and bilateral optic neuropathy is known to occur in tropical countries, probably due to malnutrition or toxicity, but not often seen in developed countries. We report seven patients in London who were not malnourished or alcoholic, and in whom no...

    Chronic cerebrospinal venous insufficiency in multiple sclerosis: A sonographer-blinded case-control study

    Clinical Neurology and Neurosurgery (Feb 2013)

    Objectives: To evaluate the presence of chronic cerebrospinal venous insufficiency (CCSVI) and cerebral venous anomalies in a consecutive series of patients with multiple sclerosis (MS), other neurologic diseases (NEU) and healthy controls (HC). Methods: A consecutive series of 80 MS patients, 41 HC and 40 NEU cases...

    Calculating the tumor volume of acoustic neuromas: Comparison of ABC/2 formula with planimetry method

    Clinical Neurology and Neurosurgery (Feb 2013)

    Objective: The ABC/2 equation is commonly applied to measure the volume of intracranial hematoma. However, the precision of ABC/2 equation in estimating the tumor volume of acoustic neuromas is less addressed. The study is to evaluate the accuracy of the ABC/2 formula by comparing with planimetry method for estimating...

    Reduced contribution of executive functions in impaired working memory performance in mild traumatic brain injury patients

    Clinical Neurology and Neurosurgery (Feb 2013)

    Aim: Mild traumatic brain injury (MTBI) is associated with often selective impairment of both working memory (WM) and the executive functions (EFs). Research indicates that one of the commonest deficits present in MTBI patients falls in the domain of WM. We aimed to investigate the role of EFs in WM impairment...

    Genetic expression profiles of adult and pediatric ependymomas: Molecular pathways, prognostic indicators, and therapeutic targets

    Clinical Neurology and Neurosurgery (Jan 2013)

    Ependymomas are tumors that can present within either the intracranial or spinal regions. While 90% of all pediatric ependymomas are intracranial, spinal cord ependymomas are more commonly found in patients 20–40 years old. Treatment for spinal lesions has achieved local control rates up to 100% following gross total...

    Epidemiology and trend of neurological diseases associated to HIV/AIDS. Experience of Mexican patients 1995–2009

    Clinical Neurology and Neurosurgery (Jan 2013)

    Objective: The aim of this study was to identify the main neurological conditions associated with HIV/AIDS in Mexican patients treated at the National Institute of Neurology and Neurosurgery (NINN) in Mexico city, the main referral center for patients with disorders of the central and peripheral nervous system....

    Nocturnal carbon dioxide monitoring in patients with idiopathic intracranial hypertension

    Clinical Neurology and Neurosurgery (Jan 2013)

    Background: Idiopathic intracranial hypertension may be associated with sleep apnea. This study evaluated the incidence of sleep breathing disorders in patients with idiopathic intracranial hypertension. Materials and Methods: Overnight respiratory monitoring was performed in 22 untreated patients with idiopathic...

    Characteristics of temporal lobe epilepsy with no ictal impairment of consciousness

    Clinical Neurology and Neurosurgery (Jan 2013)

    Introduction: The predominant manifestations of temporal lobe epilepsy (TLE) are partial seizures with impairment of consciousness (type I.B of ILAE classification), although consciousness impairment is not necessary in all seizures of patients with TLE. Nevertheless, there have been very few reports of TLE patients...

    Microsurgical clipping of previously coiled intracranial aneurysms

    Clinical Neurology and Neurosurgery (Jan 2013)

    Objective: Endovascular coiling techniques for the treatment of intracranial aneurysms have rapidly developed as an alternative option to surgical clipping. A distinct problem after endovascular coiling is the management of a residual aneurysm neck due to incomplete filling, compaction of coils or regrowth of the...

    Differentiation of pure vasogenic edema and tumor-infiltrated edema in patients with peritumoral edema by analyzing the relationship of axial and radial diffusivities on 3.0T MRI

    Clinical Neurology and Neurosurgery (Jan 2013)

    Object: The purpose of this study was to analyze the relationship of axial diffusivity (AD) and radial diffusivity (RD) in peritumoral edema of high grade glioma, metastasis, and meningioma, and to differentiate tumor-infiltrated edema from pure vasogenic edema. Materials and methods: Twenty patients with high-grade...

    Image guidance to improve reliability and data integrity of transcranial Doppler sonography

    Clinical Neurology and Neurosurgery (Jan 2013)

    Background: Principles and accuracy of image-guided transcranial Doppler (IG TCD) sonography have been published recently. However, it remains open whether combination of image guidance and TCD offers an additional clinical advantage. This study scores the accuracy of conventional TCD examinations and investigates the...

    Isolated brainstem cysticercosis: A review

    Clinical Neurology and Neurosurgery (Jan 2013)

    Objective: Review of patients with isolated brainstem cysticercus to outline the features of this form of neurocysticercosis. Methods: MEDLINE and manual search of patients with isolated brainstem cysticercus. Abstracted data included: demographic profile, clinical manifestations, neuroimaging findings, evolutive stage...

    Clinical Nuclear Medicine

    Stress Fracture of the First Metatarsal in a Fencer: Typical Appearance on Bone Scan and Pinhole Imaging

    Clinical Nuclear Medicine (Sep 2011)

    Stress fractures in the feet of athletes seldom involve the first metatarsal, with few documented case reports. We report a case of stress fracture in the base of the first metatarsal in a professional fencer with the typical scintigraphic appearance of a fracture line clearly demonstrated by selective pinhole imaging....

    Clinical Nutrition

    Pragmatic approach to nutrition in the ICU: Expert opinion regarding which calorie protein target

    Clinical Nutrition (Dec 2013)

    Background & aims:

    Since the publications of the ESPEN guidelines on enteral and parenteral nutrition in ICU, numerous studies have added information to assist the nutritional management of critically ill patients regarding the recognition of the right population to feed, the energy–protein...

    Prebiotic supplementation in preterm neonates: Updated systematic review and meta-analysis of randomised controlled trials

    Clinical Nutrition (Jun 2013)

    Background & aims: Regular administration of prebiotic oligosaccharides promote beneficial gut flora in infants. We aimed to systematically review randomized controlled trials evaluating the safety and efficacy of prebiotic oligosaccharide supplementation in preterm infants ≤37 weeks of gestation. Methods: Available...

    A 3-month at-home tube feeding in 118 bulimia nervosa patients: a one-year prospective survey in adult patients

    Clinical Nutrition (Jun 2013)

    Background & Aims: To study the 1-yr follow-up of 118 bulimia nervosa (BN) patients after a 3-month at-home tube feeding (TF) in a prospective study. Methods: At-home TF lasted 3 months, including one month of exclusive TF (no food). All patients fulfilled 4 questionnaires (score of binge/purging episodes (BP), eating...

    Geriatric Syndromes increased the Nutritional Risk in Elderly Cancer Patients Independently from Tumor Site and Metastatic Status. The ELCAPA-05 Cohort Study.

    Clinical Nutrition (Jun 2013)

    Background & Aims: We assessed the prevalence and risk factors of malnutrition in elderly cancer patients. Methods: We studied a prospective cohort of solid cancer patients aged ≥70 years at referral to two geriatric oncology clinics between 2007 and 2010. Nutrition was evaluated using the Mini-Nutritional Assessment...

    The pertinence of oral health indicators in nutritional studies in the elderly

    Clinical Nutrition (May 2013)

    Background and aim: Studies concerning the more appropriate criteria for evaluating oral health in relation to nutrition in the elderly vary greatly. There is a need to identify the most relevant criteria for classifying dental indicators of mastication in nutritional studies, so these indicators may be considered for...

    Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells

    Clinical Nutrition (Feb 2013)

    Background & aims: Chemotherapy induces an increase of intestinal permeability that is partially related to an alteration of tight junction proteins, occludin and zonula occludens-1 (ZO-1). Protective effects of glutamine on intestinal barrier function have been previously shown but the effects of other amino acids...

    Individualized vitamin A supplementation for patients with cystic fibrosis

    Clinical Nutrition (Feb 2013)

    Background & aims: To determine the vitamin A status and appropriate supplementation dosage of cystic fibrosis (CF) patients who received vitamin A supplementation based on annual serum retinol measurements. Methods: Vitamin A food intake, supplementation dosage, and serum retinol levels were obtained for 32 CF...

    Sarcopenia: prevalence and prognostic significance in hospitalized patients

    Clinical Nutrition (Feb 2013)

    Background: Sarcopenia is prevalent in older populations with many causes and varying outcomes however information for use in clinical practice is still lacking. Aims: The aim of this report is to identify the clinical determinants and prognostic significance of sarcopenia in a cohort of hospitalized acutely ill older...

    High ferritin and low transferrin saturation are associated with pre-diabetes among a national representative sample of U.S. adults

    Clinical Nutrition (Jan 2013)

    Background & aims: Iron overload is known to cause diabetes. However, the underlying mechanism is poorly understood. We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that...

    Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: A meta-analysis of randomized controlled trials

    Clinical Nutrition (Jan 2013)

    Background & aims: The efficacy of homocysteine-lowering therapy with folic acid to lower homocysteine levels in an effort to reduce cardiovascular disease (CVD) risk in patients with kidney disease remains inconclusive. We conducted a meta-analysis of relevant randomized trials to further examine this issue. Methods:...

    Randomised placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors

    Clinical Nutrition (Jan 2013)

    Background & aims: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health. Design: Fifty three mildly hypertriacylglycerolemic subjects (TAG ≥ 1.7 mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1)...

    High dietary fiber intake prevents stroke at a population level

    Clinical Nutrition (Jan 2013)

    Background & aims: This research was aimed at clarifying whether high dietary fiber intake has an impact on incidence and risk of stroke at a population level. Methods: In 1647 unselected subjects, dietary fiber intake (DFI) was detected in a 12-year population-based study, using other dietary variables, anagraphics,...

    Clinical Obesity

    A review of national health policies and professional guidelines on maternal obesity and weight gain in pregnancy

    Clinical Obesity (Jun 2014)

    Maternal obesity creates an additional demand for health–care services, as the routine obstetric care pathway requires alterations to ensure the most optimal care for obese women of childbearing age. This review examines the extent to which relevant national health documents reflect and respond to the health...

    New molecular targets in the pathophysiology of obesity and available treatment options under investigation

    Clinical Obesity (Jun 2014)

    The pharmacotherapy of obesity has historically recorded an overall poor safety and efficacy profile largely because of the complex mechanisms involved in the pathophysiology of obesity. It is hoped that a better understanding of the regulation of body weight will lead us to the development of effective and safer...

    Determining the cost of obesity and its common comorbidities from a commercial claims database

    Clinical Obesity (Nov 2013)

    What is already known about this subject

    • Obesity is highly prevalent and costly in the US.
    • Obesity often leads to other comorbid conditions, including diabetes and hypertension.
    • Obesity prevention efforts can reduce healthcare costs.

    What...

    Body mass index and depressive symptoms in primary care settings: examining the moderating roles of smoking status, alcohol consumption and vigorous exercise

    Clinical Obesity (Nov 2013)

    What is already known about this subject:

    • Depressive symptoms and obesity are highly prevalent in primary care settings.
    • Depressive symptoms and obesity are positively related; as body weight increases, individuals are more likely to display depressive symptoms.
    • ...

    An intragastric balloon produces large weight losses in the absence of a change in ghrelin or peptide YY

    Clinical Obesity (Aug 2013)

    What is already known about this subject?

    • The development of obesity is a multi-factorial process that results in an alteration in the neuroendocrine hormones that help regulate appetite and body weight. Weight loss has been shown to alter this neuroendocrine balance so as to promote weight...

    Weight loss for individuals with type 2 diabetes following a very-low-calorie diet in a community-based setting with trained facilitators for 12 weeks

    Clinical Obesity (Aug 2013)

    What is already known about this subject

    • Approximately 80% of people with type 2 diabetes mellitus (T2DM) are overweight or obese.
    • Weight loss produces numerous benefits in T2DM.
    • People with T2DM have difficulty losing and maintaining weight.

    What this study...

    Behaviours associated with weight loss maintenance and regaining in a Mediterranean population sample. A qualitative study

    Clinical Obesity (Aug 2013)

    What is already known about this subject

    • In the US, the National Weight Control Registry revealed lifestyle behaviours shared by weight loss maintainers. In the US and the UK, qualitative studies compared the experiences of weight loss maintainers and regainers.
    • High rates of physical activity, a...

    An intragastric balloon produces large weight losses in the absence of a change in ghrelin or peptide YY

    Clinical Obesity (Aug 2013)

    What does this study add?

    • There are currently limited data on the effects of intragastric balloons on appetite and weight-related hormones.
    • In the current study, we have investigated a broad range of gut hormones and adipokines and their response to weight loss induced by differing methods, and the...

    Integrating user perspectives into the development of a web-based weight management intervention

    Clinical Obesity (Jan 2013)

    The objective of this study was to adapt the design of our weight management intervention to the needs, expectations and capabilities of potential users. In study 1, we interviewed 25 people about their experiences of weight management. The findings of these interviews were combined with findings from existing theory...

    Socio-demographic and obstetrical correlates of pre-pregnancy body mass index and gestational weight gain

    Clinical Obesity (Jan 2013)

    Both pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are important determinants of a healthy pregnancy outcome and may show important variation. To study the influence of socio-demographic and obstetrical correlates on pre-pregnancy BMI and GWG, data of 54 022 singleton term pregnancies were...

    Development and validation of a new questionnaire measuring eating disordered behaviours post bariatric surgery

    Clinical Obesity (Jan 2013)

    Contextualization of post-surgery circumstances in terms of key behaviours and emotions related to eating is crucial for reliable screening. Disordered eating post surgery is characterized by frequent snacking and a sense of loss of control over food intake. The purpose of this study was to evaluate the psychometric...

    Risk factors associated with the metabolic syndrome in abdominal obesity

    Clinical Obesity (Dec 2012)

    Obesity is associated with the metabolic syndrome. However, not all obese individuals have cardiovascular risk factors (CVRF). It is not clear how many abdominally obese individuals are free of CVRF and what distinguishes them from the group of obese individuals with CVRF. In this study, we aimed to assess the...

    Qualitative content analysis of online news media coverage of weight loss surgery and related reader comments

    Clinical Obesity (Nov 2012)

    The media has the ability to affect public opinion and policy direction. Prevalence of morbid obesity in Canada is increasing; as is the only effective long-term treatment, weight loss surgery (WLS). Limited research has explored media re/presentations of WLS. The purpose of this study was to examine national online...

    Clinical Oncology

    Hormone and Radiotherapy versus Hormone or Radiotherapy Alone for Non–metastatic Prostate Cancer: A Systematic Review with Meta–analyses

    Clinical Oncology (Aug 2014)

    Aims:

    Radiotherapy is standard treatment for localised prostate cancer and is often combined with hormone treatment to prevent androgen stimulation of prostate cancer. Hormone therapy carries significant morbidity and can only be justified in the radical treatment of localised disease if it can be balanced...

    Predictive Factors for Local Control in Primary and Metastatic Lung Tumours after Four to Five Fraction Stereotactic Ablative Body Radiotherapy: A Single Institution's Comprehensive Experience

    Clinical Oncology (Jul 2014)

    Aims:

    We report the outcomes of a large lung stereotactic ablative body radiotherapy (SABR) programme for primary non–small cell lung cancer (NSCLC) and pulmonary metastases. The primary study aim was to identify factors predictive for local control.

    Materials and methods:

    In total, 311...

    Induction Gemcitabine Plus Concurrent Gemcitabine and Radiotherapy for Locally Advanced Unresectable or Resected Pancreatic Cancer

    Clinical Oncology (Jan 2014)

    Aims:

    To determine the efficacy of induction gemcitabine followed by biweekly gemcitabine concurrent with radiotherapy for locally advanced pancreatic cancer.

    Materials and methods:

    Between March 2001 and August 2009, 90 patients with unresectable (78) or resected (12) pancreatic cancer were...

    Pre–treatment Haemoglobin and Peripheral Blood Lymphocyte Count as Independent Predictors of Outcome in Carcinoma of Cervix

    Clinical Oncology (Jan 2014)

    Aims:

    To evaluate pre–treatment haemoglobin and peripheral blood lymphocyte (PBL) counts as predictors of treatment outcome in cervix carcinoma treated with radical chemoradiation.

    Materials and methods:

    Pre–treatment PBL counts and haemoglobin concentrations were retrieved from full...

    Pre-treatment Haemoglobin and Peripheral Blood Lymphocyte Count as Independent Predictors of Outcome in Carcinoma of Cervix

    Clinical Oncology (Jan 2014)

    Aims:

    To evaluate pre–treatment haemoglobin and peripheral blood lymphocyte (PBL) counts as predictors of treatment outcome in cervix carcinoma treated with radical chemoradiation.

    Materials and methods:

    Pre–treatment PBL counts and haemoglobin concentrations were retrieved from full...

    Bortezomib in Multiple Myeloma: A Practice Guideline

    Clinical Oncology (Dec 2013)

    Aims:

    Bortezomib (Velcade, PS–341), a first–in–class proteasome inhibitor, has been extensively studied either alone or in combination with other agents for the treatment of multiple myeloma. We created a provincial guideline for the use of bortezomib, in newly diagnosed...

    Panitumumab Monotherapy as a Second–line Treatment in Metastasised Colorectal Cancer: A Single Centre Experience

    Clinical Oncology (Nov 2013)

    Aims:

    To report our clinical experience of panitumumab monotherapy as a second–line treatment for patients with metastatic colorectal cancer (mCRC).

    Materials and methods:

    This retrospective, descriptive study included a series of consecutive patients receiving panitumumab monotherapy (6...

    Association between Smoking and p53 Mutation in Lung Cancer: A Meta–analysis

    Clinical Oncology (Oct 2013)

    Aims:

    To carry out a meta–analysis on the relationship between smoking and p53 gene mutation in lung cancer patients.

    Materials and methods:

    PubMed, Web of Science, ProQest and Medline were searched by using the key words: ‘lung cancer or lung neoplasm or lung carcinoma’, ‘p53 mutation’ and...

    Incidence of Skeletal-related Events Over Time from Solid Tumour Bone Metastases Reported in Randomised Trials Using Bone-modifying Agents

    Clinical Oncology (Apr 2013)

    Aims: Skeletal-related events (SREs) in patients with bone metastases decrease a patient's quality of life and functional status. Although bone-modifying agents have been found to reduce the time to first on-trial SRE and decrease the total incidence of SREs in randomised clinical trials, standard practice in the...

    Oesophageal Chemoradiotherapy in the UK—Current Practice and Future Directions

    Clinical Oncology (Mar 2013)

    The SCOPE 1 trial closed to recruitment in early 2012 and has demonstrably improved the quality of UK radiotherapy. It has also shown that there is an enthusiastic upper gastrointestinal clinical oncology community that can successfully complete trials and deliver high-quality radiotherapy. Following on from SCOPE 1,...

    Quality of Life after Radical Radiotherapy for Prostate Cancer: Longitudinal Study from a Randomised Trial of External Beam Radiotherapy Alone or in Combination with High Dose Rate Brachytherapy

    Clinical Oncology (Feb 2013)

    Aim: To compare prospective, long-term quality of life in patients randomised to external beam radiotherapy (EBRT) alone or with a boost of high dose rate (HDR) brachytherapy. Materials and methods: In total, 216 patients participating in the UK randomised trial of EBRT ± HDR brachytherapy were included in this...

    Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk

    Clinical Oncology (Feb 2013)

    The clinical applications of stereotactic body radiotherapy or stereotactic ablative radiotherapy (SABR) for the treatment of primary and metastatic tumours of different organ sites have been expanding rapidly in the recent decade. SABR requires advanced technology in radiotherapy planning and image guidance to deliver...

    Clinical Otolaryngology

    Consultant–led, multidisciplinary balance clinic: process evaluation of a specialist model of care in a district general hospital

    Clinical Otolaryngology (May 2014)

    Objective:

    A specialist balance clinic to effectively deal with dizzy patients is recommended by ENT–UK. We audit the patient pathway before and following the introduction of a consultant–led dedicated balance clinic.

    Design:

    Process evaluation and audit.

    Setting:

    ENT...

    Quality of life and associated factors in persons with Chronic Rhinosinusitis in the general population

    Clinical Otolaryngology (Oct 2013)

    Objectives:

    The European Position Paper on Rhinosinusitis and Nasal Polyps describes methods to perform population-based and clinical studies on Chronic Rhinosinusitis in a standardized way and it also describes how to clinical investigate CRS. The aim of this cross sectional study was to evaluate Quality of...

    Prospective evaluation of reliability of cone beam computed tomography in detecting different position of vibroplasty middle ear implants

    Clinical Otolaryngology (May 2013)

    Objectives: This study had the following objectives: (i) To determine the accuracy of determination of Vibrant Soundbridge position in the spectrum of typically implanted sites in the middle ear. (ii) To assess inter-observer agreement between 3 observers with different levels of radiology experience. (iii) To...

    Anti-adhesive effect of a thermosensitive poloxamer applied after the removal of nasal packing in endoscopic sinus surgery: A randomized multicentre clinical trial

    Clinical Otolaryngology (Apr 2013)

    Objective: To compare the efficacies of a thermosensitive poloxamer and Merogel in preventing adhesion applied after the removal of nasal packing in endoscopic sinus surgery as a non-inferiority trial. Study design: Randomized, multicenter, single-blind, active-controlled, matched-pair study. Setting: Yonsei University...

    Using routine data to estimate survival and recurrence in head and neck cancer: Our preliminary experience in twenty patients

    Clinical Otolaryngology (Apr 2013)

    Head and neck cancer represents a significant health problem in the UK, with nearly 8000 new cases diagnosed in England and Wales in 2011[1,2]. Despite multi-modality treatment, tumour recurrence rates remain high. Data on recurrence is limited to clinical trial settings or small retrospective series[3]. However,...

    Anti-adhesive effect of a thermosensitive poloxamer applied after the removal of nasal packing in endoscopic sinus surgery: A randomized multicentre clinical trial

    Clinical Otolaryngology (Apr 2013)

    Objective: To compare the efficacies of a thermosensitive poloxamer and Merogel in preventing adhesion applied after the removal of nasal packing in endoscopic sinus surgery as a non-inferiority trial. Study design: Randomized, multicenter, single-blind, active-controlled, matched-pair study. Setting: Yonsei University...

    Using routine data to estimate survival and recurrence in head and neck cancer: Our preliminary experience in twenty patients

    Clinical Otolaryngology (Apr 2013)

    Head and neck cancer represents a significant health problem in the UK, with nearly 8000 new cases diagnosed in England and Wales in 2011[1,2]. Despite multi-modality treatment, tumour recurrence rates remain high. Data on recurrence is limited to clinical trial settings or small retrospective series[3]. However,...

    Clinical Radiology

    MRI features of the complete histopathological response of locally advanced rectal cancer to neoadjuvant chemoradiotherapy

    Clinical Radiology (Jan 2012)

    Aim: To describe the post-chemoradiotherapy magnetic resonance imaging (MRI) features of locally advanced rectal carcinoma (LARC) in which there has been a complete histopathological response to neoadjuvant chemoradiotherapy (CRT). Materials and methods: This retrospective cohort study was performed between January...

    Clinical Rhematology

    Rheumatologic manifestations of benign and malignant haematological disorders

    Clinical Rhematology (Jun 2011)

    Diseases of blood and lymphoreticular system can have multisystem manifestations. Rheumatologic involvement has been reported in association with many benign and malignant haematological disorders; these patients are equally likely to present to both clinical rheumatologists and haematologists. This review focuses on...

    Clinical Science

    PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfuntion in rats with streptozotocin-induced diabetes

    Clinical Science (Sep 2011)

    A, late peak velocity of diastolic filling; DHE, dihydroethidium; E, peak velocity of early diastolic filling; EF, ejection fraction; FS, fractional shortening; H&E, haematoxylin and eosin; HR, heart rate; IVRT, isovolumic relaxation time; IVSd, interventricular septal thickness in diastole; IVSs, interventricular...

    Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model

    Clinical Science (Jun 2011)

    CKD (chronic kidney disease) has become a public health problem. The therapeutic approaches have been able to reduce proteinuria, but have not been successful in limiting disease progression. In this setting, cell therapies associated with regenerative effects are attracting increasing interest. We evaluated the effect...

    Clinical Transplantation

    Test performance characteristics of quantitative nucleic acid testing for polyomaviruses in kidney and kidney-pancreas transplant recipients

    Clinical Transplantation (Aug 2013)

    Screening for polyoma BK virus (BK) using nucleic testing (NAT) is recommended for kidney and kidney-pancreas transplant recipients, but the performance characteristics of quantitative BK NAT at different thresholds of plasma BK viral loads are unclear. We aim to evaluate the diagnostic accuracy of quantitative BK...

    A single-center analysis of abdominal imaging in the evaluation of kidney transplant recipients

    Clinical Transplantation (Aug 2013)

    Many transplantation programs utilize noninvasive abdominal and pelvic imaging in the pre-operative evaluation of recipient candidates. Practice patterns vary, and consensus guidelines addressing the risks and benefits of computed tomography (CT) and magnetic resonance imaging (MRI) in the pre-transplant evaluation...

    Alemtuzumab induction in simultaneous pancreas and kidney transplantation

    Clinical Transplantation (Aug 2013)

    Background:

    Alemtuzumab (AZ) is a monoclonal anti-CD52 antibody used as an induction agent in organ transplantation. Few studies have analyzed this agent in the context of simultaneous kidney–pancreas transplantation (SPKT).

    Methods:

    We examined US registry data of SPKT recipient outcomes from...

    The impact of mean first-year heart rate on outcomes after heart transplantation: does it make a difference?

    Clinical Transplantation (Aug 2013)

    Background:

    Cardiac denervation following transplantation has a variable effect on heart rate (HR), and the consequence of this is not known. We examined the impact of first-year HR on five-yr outcomes after heart transplant.

    Methods:

    We evaluated 544 heart transplant recipients from 1994 to 2008....

    Delayed allograft inflammation following alemtuzumab induction for kidney transplantation

    Clinical Transplantation (Aug 2013)

    Background:

    In a recent clinical trial in kidney transplant recipients, induction with alemtuzumab and rabbit-antithymocyte globulin (r-ATG) was equally effective in preventing rejection during the first post-transplant year; however, this study did not include protocol biopsies.

    Methods:

    The aim...

    A quantitative assessment model of T-cell immune function for predicting risks of infection and rejection during the early stage after liver transplantation

    Clinical Transplantation (Aug 2013)

    Although more and more clinical studies indicated that ImmuKnow assay could efficiently assess the immune status of recipients, it still has the challenge to predict the occurrence of clinical adverse events. This study aimed to establish a quantitative assessment model, which could more efficiently predict immune...

    Cyclosporine versus everolimus: effects on the glomerulus

    Clinical Transplantation (Jun 2013)

    Inhibitors of the mammalian target of rapamycin (mTOR) have been associated with proteinuria. We studied the development of proteinuria in renal transplant recipients (RTR) treated with the mTOR inhibitor everolimus in comparison with a calcineurin inhibitor. We related the presence of proteinuria to...

    Low-pressure pneumoperitoneum during laparoscopic donor nephrectomy to optimize live donors’ comfort

    Clinical Transplantation (Jun 2013)

    Nowadays, laparoscopic donor nephrectomy (LDN) has become the gold standard to procure live donor kidneys. As the relationship between donor and recipient loosens, it becomes of even greater importance to optimize safety and comfort of the surgical procedure. Low-pressure pneumoperitoneum has been shown to reduce...

    Adult left liver transplantation from split livers and living donors: a 14-year single-center experience

    Clinical Transplantation (Jun 2013)

    Background:

    In an era of organ scarcity, the use of left liver grafts for adult recipients could increase the access to liver transplantation (LT). The aim of this study was to evaluate the results in a single-center series of adult left LT over a 14-yr period.

    Patients and methods:

    Between March...

    Understanding the relationship between trust in health care and attitudes toward living donor transplant among African Americans with end-stage renal disease

    Clinical Transplantation (Jun 2013)

    Transplantation is the favored therapy for patients with end-stage renal disease (ESRD). Unfortunately, demand for available organs far outpaces the supply. African Americans are disproportionately affected by the ever-widening gap between organ supply and demand. Additionally, structural, biological, and social...

    Epstein–Barr virus reactivation in allogeneic stem cell transplantation is highly related to cytomegalovirus reactivation

    Clinical Transplantation (Jun 2013)

    Monitoring of Epstein–Barr virus (EBV) load and pre-emptive rituximab is an appropriate approach to prevent post-transplant lymphoproliferative disease (PTLD) occurring after hematopoietic stem cell transplantation (HSCT). This pre-emptive approach, based on EBV-DNA monitoring through a quantitative polymerase chain...

    Normal adiponectin levels in kidney transplant patients with hypertension

    Clinical Transplantation (Jun 2013)

    Background:

    Kidney transplant patients are a unique population where despite correction of their kidney function they are still considered to be at high cardiovascular (CV) risk. Adiponectin, an adipokine secreted from adipocytes, has protective CV properties. Patients with essential hypertension (HTN) have...

    The role of diet and physical activity in post-transplant weight gain after renal transplantation

    Clinical Transplantation (Jun 2013)

    Background:

    Long-term survival of renal transplant recipients (RTR) has not improved over the past 20 yr. The question rises to what extent lifestyle factors play a role in post-transplant weight gain and its associated risks after transplantation.

    Methods:

    Twenty-six RTR were measured for body...

    Safety and efficacy of sorafenib for the treatment of recurrent hepatocellular carcinoma after liver transplantation

    Clinical Transplantation (Jun 2013)

    Introduction:

    Recurrent hepatocellular carcinoma (HCC) following liver transplantation (LT) carries a poor prognosis. The aim of our study was to assess the safety and efficacy of sorafenib in patients with recurrent HCC following LT.

    Methods:

    A prospectively maintained LT database was...

    Effect of mycophenolate mofetil on hematological side effects incidence in renal transplant recipients

    Clinical Transplantation (Jun 2013)

    Mycophenolate mofetil (MMF), an immunosuppressant administered after solid organ transplantation, is generally well tolerated; however, it frequently causes hematological toxicity. In this study, we aimed to assess the relation between the pharmacokinetic parameters of MMF metabolites (mycophenolic acid [MPA] and...

    Post-transplant lymphoproliferative disorder in adult liver transplant recipients: a South American multicenter experience

    Clinical Transplantation (Jun 2013)

    Post-transplant lymphoproliferative disorder (PTLD) is a major and potentially life-threatening complication after solid-organ transplantation. The aim of this study was to describe the disease characteristics, clinical practices, and survival related to PTLD in adult orthotopic liver transplant (OLT) recipients in...

    Postoperative respiratory management in living donor lobar lung transplantation

    Clinical Transplantation (Jun 2013)

    Background:

    We evaluated postoperative respiratory management of living donor lobar lung transplantation (LDLLT).

    Methods:

    Perioperative variables were reviewed in 21 patients who underwent LDLLT at our institution. Recipients were kept intubated for at least two d after LDLLT to maintain optimal...

    Cytomegalovirus infection post-pancreas–kidney transplantation – results of antiviral prophylaxis in high-risk patients

    Clinical Transplantation (Jun 2013)

    Background:

    Cytomegalovirus (CMV) is a major pathogen affecting solid organ transplant (SOT) recipients. Prophylactic strategies have decreased the rate of CMV infection/disease among SOT. However, data on the effect of current prophylactic strategies for simultaneous pancreas–kidney (SPK) or pancreas after...

    Prediction of kidney graft failure using clinical scoring tools

    Clinical Transplantation (Jun 2013)

    Background:

    Donor organ quality is a key determinant of graft function, and considerable efforts have been made to identify donor and transplant factors predicting inferior outcomes. This has resulted in the development of various scoring tools to aid in allocation of kidneys.

    Methods:

    The...

    Cystatin C and albuminuria as predictors of long-term allograft outcomes in kidney transplant recipients

    Clinical Transplantation (Feb 2013)

    Although cystatin C (Cys) and albuminuria (Alb) are predictors of end-stage renal disease in the general population, there are limited data about the performance of these markers alone or combined with respect to the prediction of the kidney transplant outcome. We assessed the ability of one-yr creatinine (Cr), MDRD...

    The role of belataceptin transplantation: results and implications of clinical trials in the context of other new biological immunosuppressant agents

    Clinical Transplantation (Dec 2012)

    Although conventional immunosuppressive agents such as calcineurin inhibitors, have substantially reduced the risk of acute rejection, they have had less impact on the long-term survival. This is likely to be related to the adverse effects of such agents in terms of impaired renal function, hypertension, and...

    Association of mycophenolic acid dose with efficacy and safety events in kidney transplant patients receiving tacrolimus: an analysis of the Mycophenolic acid Observational REnal transplant registry

    Clinical Transplantation (Nov 2012)

    Background: Dose-finding studies for mycophenolic acid (MPA) in tacrolimus-treated kidney transplant patients are lacking. Methods: Data from 901 de novo kidney transplant recipients enrolled in the prospective, non-interventional Mycophenolic acid Observational REnal (MORE) transplant registry were analyzed according...

    Delayed graft function is not associated with an increased incidence of renal allograft rejection

    Clinical Transplantation (Oct 2012)

    Delayed graft function (DGF) is considered as a risk factor for renal allograft rejection, but this association might be confounded by diagnostic biases (e.g., higher biopsy frequency in patients with DGF, inclusion of clinically diagnosed rejection episodes, and limited details on the rejection phenotype). This...

    A focused educational program after religious services to improve organ donation in Hispanic Americans

    Clinical Transplantation (Oct 2012)

    Religion is an important determinant in Hispanic Americans (HA) becoming organ donors as HA often believe religion forbids donation. We investigated the effect of an educational program targeting HA organ donation in places of worship. A prospective observational study was conducted at four Catholic churches with a...

    Does anti-hepatitis B virus vaccine make any difference in long-term number of liver transplantation?

    Clinical Transplantation (Oct 2012)

    Background: Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality worldwide. Chronic hepatitis B infection is associated with an increased risk of cirrhosis, hepatic decompensation, and hepatocellular carcinoma. Our aim is to analyze, through a mathematical model, the potential impact of...

    BK virus viremia in a well-HLA-matched kidney transplant population mainly on low-dose cyclosporine-based immunosuppression

    Clinical Transplantation (Oct 2012)

    The incidence and clinical course of polyomavirus-associated nephropathy (PyVAN) in our well-HLA-matched kidney transplant population mainly on low-dose cyclosporine-based triple-drug immunosuppression has not been described in detail. We aimed to characterize our patients with PyVAN and BK virus (BKV) viremia. Among...

    Determinants of vitamin D status in long-term renal transplant patients

    Clinical Transplantation (Oct 2012)

    In this study, we explored the determinants of vitamin D status in a large cohort of stable, Long-term renal transplant (RTx) patients. Serum 25(OH)D concentrations, and bone biochemistry parameters, were retrospectively analyzed from 266 RTx patients (>10 yr post-engraftment) presenting to clinic over the course of a...

    Which patients are more likely to benefit from renal transplantation?

    Clinical Transplantation (May 2012)

    Background: We evaluated whether the advantages conferred by renal transplantation encompass all individuals or whether they favor more specific groups of patients. Methods: One thousand and fifty-eight patients on the transplant waiting list and 270 receiving renal transplant were studied. End points were the...

    Transumbilical portal venous catheterization: a useful adjunct in left lobe living donor liver transplantation

    Clinical Transplantation (May 2012)

    To improve the processes used for perfusion of the explanted graft and measuring the portal venous pressure (PVP) in adult living donor transplantation (LDLT), we performed transumbilical portal venous catheterization (TPVC) to reopen the umbilical vein and insert the catheter for seven adult patients undergoing left...

    Clinics in Perinatology

    Neonatal Diuretic Therapy: Furosemide, Thiazides, and Spironolactone

    Clinics in Perinatology (Jan 2012)

    Diuretics are commonly used to treat infants with oxygen-dependent chronic lung disease. However, there are limited data suggesting a beneficial effect of long-term diuretic therapy on pulmonary function or clinical outcome in this population. Furthermore, data available for review were primarily obtained before the...

    Antibiotic Use and Misuse in the Neonatal Intensive Care Unit

    Clinics in Perinatology (Jan 2012)

    Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common...

    CNS Neuroscience & Therapeutics

    Inordinate Glucose Variation Poststroke is Associated with Poor Neurological Improvement in Patients Without History of Diabetes

    CNS Neuroscience & Therapeutics (Apr 2014)

    Introduction:

    Glucose variation is an important risk factor for the complications of diabetes mellitus. The plasma glucose level poststroke is in continuous fluctuation. However, whether the variation influences neurological improvement remains unknown.

    Aims:

    This observational study aimed to...

    Complementary Therapies in Clinical Practice

    Effects of music on physiological and behavioral responses of premature infants: A randomized controlled trial

    Complementary Therapies in Clinical Practice (May 2013)

    Introduction: Despite persuasive theories about the beneficial effects of music and singing in developmental care for premature infants, few small studies are available in this regard. We conducted this study to investigate the physiological and behavioral responses of premature infants to recorded lullaby music and...

    Complementary therapy for carers on a transplant unit

    Complementary Therapies in Clinical Practice (May 2013)

    Background: This paper reports on the evaluation of a Carers Complementary Therapy Project on a Haematology and Transplant Unit. Aim: To evaluate the project using quantitative and qualitative data. Design: Data was collected on consultation forms and entered into a spreadsheet for a study period of 24 months. Data was...

    Is craniosacral therapy effective for migraine? Tested with HIT-6 Questionnaire

    Complementary Therapies in Clinical Practice (Nov 2012)

    Objective: To determine whether or not craniosacral therapy alleviates migraine symptoms. Methods: A cross-over experimental design was used with twenty participants, aged between 20 and 50 years, who suffered from at least two migraine attacks per month. Participants were randomly assigned to two equal-sized groups, A...

    Assessment of general public perceptions toward traditional medicines used for aphrodisiac purpose in state of Penang, Malaysia

    Complementary Therapies in Clinical Practice (Jul 2012)

    The study aims to evaluate general public perceptions regarding the use of Traditional and Complementary Medicines (TCM) for aphrodisiac purposes. A questionnaire based, cross-sectional study was undertaken. Respondents were selected in the state of Penang, Malaysia. A total of 392 respondents were included in the...

    Comparing the effects of ice massage and acupressure on labor pain reduction

    Complementary Therapies in Clinical Practice (Jul 2012)

    Background: Childbirth is arguably one of the most painful experiences women undergo during their lives. This study aimed to compare the effects of ice massage, acupressure and placebo in reducing the intensity of labor pain in pregnant women from selected hospitals in Tehran, Iran. Methods: A quasi-experimental study...

    Diaphragmatic breathing exercise as a therapeutic intervention for control of oxidative stress in type 2 diabetes mellitus

    Complementary Therapies in Clinical Practice (Jul 2012)

    Present study aims to evaluate the effect of diaphragmatic breathing on anthropometry, blood pressure, glycemic control and oxidative stress in patients with type 2 diabetes on standard care in comparison with standard care alone. Study involved 123 patients who were assigned to receive either standard care or with...

    Reflexology has an acute (immediate) haemodynamic effect in healthy volunteers: A double-blind randomised controlled trial

    Complementary Therapies in Clinical Practice (Jul 2012)

    Reflexologists claim that massage to specific points of the feet increases blood supply to internal organs. This study measured changes in cardiovascular parameters in subjects receiving reflexology to areas of their feet thought to correspond to the heart (intervention) compared with other areas which are not...

    Providing therapies to the opposite sex: Views of complementary therapists working in clinical and private practice settings

    Complementary Therapies in Clinical Practice (Jun 2012)

    Aim: The study explored the experiences of working with the opposite sex as a therapists in a cancer care centre (CCC). Methodology: Therapists (n = 17) participated in three focus groups. Audiotapes were transcribed verbatim and analysed. Results: Themes and sub-themes were identified; these related to maintaining...

    Reported treatment strategies for reflexology in cardiac patients and inconsistencies in the location of the heart reflex point: An online survey

    Complementary Therapies in Clinical Practice (Jun 2012)

    Background: Reflexology texts are inconsistent with regard to the location of the heart point and contradictory with regard to the correct reflexology approach to cardiac patients. We aimed to determine the impact of these inconsistencies on the practice of Association of Reflexologists (AoR) members. Method: Online...

    The effects of clinical aromatherapy for anxiety and depression in the high risk postpartum woman – A pilot study

    Complementary Therapies in Clinical Practice (Jun 2012)

    Objectives: The aim of this study was to determine if aromatherapy improves anxiety and/or depression in the high risk postpartum woman and to provide a complementary therapy tool for healthcare practitioners. Design: The pilot study was observational with repeated measures. Setting: Private consultation room in a...

    The rise and fall of complementary medicine in National Health Service hospitals in England

    Complementary Therapies in Clinical Practice (Jun 2012)

    Whilst Complementary and Alternative Medicine (CAM) has never been systematically integrated into National Health Service (NHS) provision, there has been some limited evidence of a developing presence of CAM in NHS hospital based nursing and midwifery. This paper reports on a qualitative study that sought to document...

    Complementary and alternative treatment use for autism spectrum disorders

    Complementary Therapies in Clinical Practice (Jun 2012)

    Autism spectrum disorders (ASD) have rapidly become one of the more frequent reasons for seeking diagnosis and treatment. Depending on health care services available, the standard treatment options are often limited; many parents turn to complementary and alternative medicine (CAM) approaches. CAM treatments and some...

    Patient experience of acupuncture provision in a GP practice

    Complementary Therapies in Clinical Practice (Jun 2012)

    Patient experience of acupuncture at a GP surgery was evaluated over 18 months. Patients were referred for six acupuncture treatments of 45 min by 10 practising GPs. Measure Your Medical Outcome Profile (MYMOP), was completed before the first treatment and at the start of the final consultation. A patient experience...

    Complementary Therapies in Medicine

    A clinical observation of irritable bowel syndrome treated by traditional Chinese spinal orthopedic manipulation

    Complementary Therapies in Medicine (Oct 2013)

    Objective:

    To evaluate the clinical effect of Traditional Chinese Spinal Orthopedic Manipulation (TCSOM) in treating Irritable Bowel Syndrome (IBS) in comparison with Pinaverium Bromide Dicetel (PBD), and to assess a possible cause for IBS.

    Methods:

    60 cases of IBS patients were randomly divided...

    Syzygium cumini (L.) Skeels., a novel therapeutic agent for diabetes: Folk medicinal and pharmacological evidences

    Complementary Therapies in Medicine (May 2013)

    Objectives: During the past few decades numerous folk medicinal and scientific investigations on the antidiabetic effects of jambolan (Syzygium cumini (L.) Skeels) have been reported. However no comprehensive evidence-based review is available. Hence this review was aimed to summarize the antidiabetic effects of...

    A double blind randomised placebo controlled study of propolis (bee glue) effectiveness in the treatment of severe oral mucositis in chemotherapy treated children

    Complementary Therapies in Medicine (May 2013)

    Objectives: Chemotherapy-induced oral mucositis (OM) is a debilitating side effect. In addition to standard therapy, patients often use complementary and alternative medicine to treat OM. Design: Double blind randomised placebo controlled study assessing propolis (bee glue) efficacy for chemotherapy-induced severe OM...

    National survey of yoga practitioners: Mental and physical health benefits

    Complementary Therapies in Medicine (May 2013)

    Objectives: To describe yoga practice and health characteristics of individuals who practice yoga, and to explore their beliefs regarding the effects of their yoga practice on their health. Design: A cross-sectional design with anonymous online surveys. Setting: 4307 randomly selected individuals from 15 US Iyengar...

    Reflexology has no immediate haemodynamic effect in patients with chronic heart failure: A double blind randomised controlled trial

    Complementary Therapies in Medicine (Apr 2013)

    Aims: This study measured the effects of reflexology in 12 reflexology-naive patients with chronic heart failure in a placebo-controlled, double blind randomised controlled study design. Method: Outcomes included ‘beat-to-beat’ non-invasive continuous measurement of cardiovascular parameters and measurement of state of...

    The use of placebo interventions in clinical practice

    Complementary Therapies in Medicine (Dec 2012)

    Although a considerable number of mostly quantitative surveys have investigated the frequency and circumstances of the use of placebo interventions in clinical practice, it remains rather unclear what role placebo interventions really have outside clinical and laboratory research and why they are used. In this article...

    Naturopaths and Western herbalists’ attitudes to evidence, regulation, information sources and knowledge about popular complementary medicines

    Complementary Therapies in Medicine (Dec 2012)

    Background: The practice of naturopathy and Western herbal medicine (WHM) was built on traditional evidence but may be undergoing change with the advent of scientific evidence. The aims of this research were to provide a better understanding of practitioners’ attitudes towards evidence, information sources,...

    Effects of woodland walking on salivary stress markers cortisol and chromogranin A

    Complementary Therapies in Medicine (Dec 2012)

    Objective: We investigated the effect of walking through woodland on salivary endocrinological stress markers, cortisol and chromogranin A (CgA). Design: From 20 healthy males, saliva samples were collected immediately before and after the walk, and 20min and 40min after that. In addition, using visual analog scales,...

    Efficacy of cranial electric stimulation for the treatment of insomnia: A randomized pilot study

    Complementary Therapies in Medicine (Dec 2012)

    Objectives: This pilot study examined the potential efficacy of cranial electric stimulation for the treatment of insomnia. Design: The researchers tested the hypothesis through a randomized, double-blind, and placebo controlled clinical trial. The researchers approached eligible subjects who scored 21 or above on the...

    How patients choose osteopaths: A mixed methods study

    Complementary Therapies in Medicine (Nov 2012)

    Objectives: To explore how patients choose individual osteopaths to consult; to test whether patients’ preferences for osteopaths depend on gender, the osteopath's qualifications, and the cost of treatment; to explore patients’ perspectives. Design: An explanatory mixed methods design incorporating a quasi-experimental...

    Physiological changes in energy healers during self-practice

    Complementary Therapies in Medicine (Jun 2012)

    Objective: The physiological status of energy healers during self-practice (activating the healing state without the presence of a recipient) has rarely been examined. This study assessed self practice-related changes in autonomic nervous system (ANS) activity in Reiki Masters and advanced Reconnective Healers. Design:...

    The effect of olive oil on prevention of striae gravidarum: A randomized controlled clinical trial

    Complementary Therapies in Medicine (Jun 2012)

    Objectives: Striae gravidarum (SG) is one of the cutaneous physiological changes during pregnancy with a high prevalence. This study aimed to evaluate the effect of olive oil in prevention of SG. Design: Randomized controlled clinical trial. Setting: Health care centers and three Hospitals affiliated to Tehran...

    Congenital Anomalies

    C677T mutation in methylenetetrahydrofolate reductase gene and neural tube defects: Should Japanese women undergo gene screening before pregnancy?

    Congenital Anomalies (Jun 2013)

    We analyzed the role of maternal C677T mutation in methylenetetrahydrofolate reductase (MTHFR) gene on spina bifida development in newborns. A total of 115 mothers who had given birth to a spina bifida child (SB mothers) gave 10ml of blood together with written informed consent. The genotype distribution of C677T...

    Congenital Heart Disease

    The Effect of Angiotensin–converting Enzyme Inhibitors on the Rate of Ascending Aorta Dilation in Patients with Bicuspid Aortal Valve

    Congenital Heart Disease (Apr 2014)

    Background:

    Bicuspid aortic valve (BAV), the most common congenital heart defect, is associated with progressive aortic dilation and increased risk of dissection and rupture. The use of an angiotensin–converting enzyme (ACE) inhibitor has recently proven effective in slowing the rate of aortic dilation...

    National Prescribing Trends for Heart Failure Medications in Children

    Congenital Heart Disease (Apr 2014)

    Background:

    The treatment of acute decompensated heart failure (ADHF) in adults has changed considerably over the past decade, and these changes have coincided with a reduction in inpatient mortality. At this time, national trends in medication prescribing among children hospitalized with ADHF are...

    Atrial Tachyarrhythmias and the Cox-maze Procedure in Congenital Heart Disease

    Congenital Heart Disease (Dec 2012)

    Introduction: Atrial tachyarrhythmias, particularly atrial flutter and fibrillation, are commonly associated with congenital heart disease and are a major cause of morbidity and mortality. The Cox-maze procedure, introduced by Dr. James Cox in 1987, is effective at controlling atrial fibrillation in structurally normal...

    Doppler Tissue Imaging Provides an Estimate of Pulmonary Arterial Pressure in Children with Pulmonary Hypertension Due to Congenital Intracardiac Shunts

    Congenital Heart Disease (Dec 2012)

    Objective: The aim of this study is to determine the relationship between the cardiac catheterization findings and pulsed-wave (PW) Doppler and Doppler tissue imaging (DTI) in pulmonary arterial hypertension patients with congenital heart disease with intracardiac shunts. Design and Patients: The present study aims to...

    The American Heart Association's Recent Scientific Statement on Cardiac Critical Care: Implications for Pediatric Practice

    Congenital Heart Disease (Dec 2012)

    A writing group sponsored by the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the Council on Quality of Care and Outcomes Research of The American Heart Association has recently formulated a roadmap to meet the...

    Transesophageal Echocardiography Probe Insertion Failure in Infants Undergoing Cardiac Surgery

    Congenital Heart Disease (Dec 2012)

    Background: The use of intraoperative transesophageal echocardiography (iTEE) in neonates ≤4 kg has not been systematically described. We sought to describe the use of and determine risk factors for iTEE probe insertion failure in small infants. We also sought to develop an algorithm for predicting the likelihood of...

    Facilitators of and Barriers to Advance Care Planning in Adult Congenital Heart Disease

    Congenital Heart Disease (Dec 2012)

    Background: Most adults with congenital heart disease (CHD) are interested in discussing matters related to advance care planning (ACP) early in the disease course, yet few such conversations actually occur. We aimed to evaluate factors that impact these discussions between patients and adult CHD providers. Methods:...

    Assessment of the Cerebral Circulation in Adults with Coarctation of the Aorta

    Congenital Heart Disease (Dec 2012)

    Aims: There is a fivefold increase in the frequency of intracranial aneurysm (IA) in adults with coarctation of the aorta (CoA). Current guidelines for management of adults with CoA recommend computed tomography angiography (CTA) or magnetic resonance imaging of the intracranial vessels. However, this recommendation...

    Congestive Heart Failure

    Ethics in the Treatment of Advanced Heart Failure: Palliative Care and End-of-Life Issues

    Congestive Heart Failure (Aug 2011)

    Advanced heart failure (HF) is a life-shortening condition, yet there are increasing treatments and implantable devices available to clinicians to manage patients with advanced HF. Planning for adverse events and the end of life, formulated as “preparedness planning,” can be integrated into HF care early in illness....

    Critical Care Clinics

    Why Candida Sepsis Should Matter to ICU Physicians

    Critical Care Clinics (Aug 2013)

    The incidence of candidemia and invasive Candida infections has increased substantially over the last 2 decades. These infections are associated with risk factors that characterize intensive care unit patients. Candidemia and invasive Candida are highly morbid and associated with significantly...

    Infective Endocarditis in the Intensive Care Unit

    Critical Care Clinics (Aug 2013)

    Infective endocarditis has many facets and various expressions depending on the site of infection, microorganism, underlying heart lesion, immune status of the host, and remote effects such as emboli, organ dysfunction, and the condition of the host. Diagnosis depends on meticulous clinical examination, blood...

    Abdominal Catastrophes in the Intensive Care Unit Setting

    Critical Care Clinics (Aug 2013)

    Patients in the setting of the intensive care unit can develop intra-abdominal complications that may worsen outcome. Clinical suspicion of such complications coupled with early diagnosis and treatment may reduce morbidity and mortality associated with these processes. This article addresses the diagnosis and...

    Management of Severe Malaria in the Intensive Care Unit

    Critical Care Clinics (Aug 2013)

    Severe malaria is a medical emergency requiring early intervention to prevent death. This article highlights key aspects of the management of severe malaria syndromes in the intensive care unit, with a focus on individual case management of imported malaria. Key differences in the presentation, management, and...

    Current atherosclerosis reports

    The SHAPE Guideline: Ahead of Its Time or Just in Time?

    Current atherosclerosis reports (Sep 2011)

    In 2006, a grass roots movement called SHAPE (Screening for Heart Attack Prevention and Education) published a novel practice guideline for cardiovascular screening in the asymptomatic at-risk population. It suggested the use of noninvasive tests for subclinical atherosclerosis in cardiovascular risk assessment to...

    Current opinion in allergy and clinical immunology

    Diagnosis of drug-induced skin reactions: a future role for computer-aided systems?

    Current opinion in allergy and clinical immunology (Sep 2011)

    Purpose of review: The diagnosis of drug-induced hypersensitivity reactions is a common clinical challenge and the skin is considered a signal organ for a large percentage of these reactions. In order to assure clinical improvement of the patient, nondermatologists in primary or intensive care settings attending to...

    Current Opinion in Cardiology

    Radionuclide cardiac stress testing

    Current Opinion in Cardiology (Sep 2011)

    Purpose of review: To briefly review the field of radionuclide stress imaging, including recent technologic advances and clinical applications. Recent findings: ECG gating and attenuation correction help increase specificity and accuracy of myocardial single-photon emission computed tomography (SPECT) imaging....

    Current Opinion in Infectious Diseases

    New approaches in HIV eradication research

    Current Opinion in Infectious Diseases (Nov 2011)

    Purpose of review: Despite the proven efficacy of highly active antiretroviral therapy in reducing mortality and morbidity of HIV infection, longer-term strategies are less well defined and there is renewed interest in HIV eradication. This review will describe the major obstacles that need to be overcome and the key...

    Current problems in cardiology

    Myocardial revascularization by percutaneous coronary intervention: past, present, and the future.

    Current problems in cardiology (Sep 2011)

    Percutaneous coronary revascularization was introduced over 30 years ago by Dr Andreas Gruntzig. This event catapulted adult invasive cardiology from a diagnostic entity to a therapeutic modality, which has since become the most frequently performed coronary revascularization procedure worldwide. This success has been...

    Current treatment options in cardiovascular medicine

    Perioperative management of pulmonary hypertension in children with critical heart disease.

    Current treatment options in cardiovascular medicine (Sep 2011)

    Pulmonary hypertension (PHTN) is common to a variety of conditions occurring in infants and children presenting to the intensive care unit. A fundamental understanding of the response of the right ventricle to an increase in afterload and the clinical syndromes responsible for PHTN is essential for managing patients...

    Perioperative mechanical circulatory support in children with critical heart disease.

    Current treatment options in cardiovascular medicine (Sep 2011)

    The treatment of cardiovascular failure in the perioperative period with the use of mechanical circulatory support is a well-recognized, well-developed, and commonly utilized treatment modality. Regardless of the exact circumstances of initiation, the use of a support device is a “bridge.” Where there has been an acute...

    Current treatment options in neurology

    Treatment of memory loss with herbal remedies

    Current treatment options in neurology (Sep 2011)

    Increased rates of dementia throughout the world are creating an emergent need for successful preventive and treatment strategies. Despite a lack of any significant scientific basis, herbal remedies and other types of “complementary and alternative medicine” (CAM) are being aggressively marketed for both prophylactic...

    Der Chirurg

    Upper and lower eyelid blepharoplasty - Development of aesthetic periocular plastic surgery

    Der Chirurg (Sep 2011)

    The article describes the indications and techniques for blepharoplasty of the upper and lower eyelids as well as combinations with other eyelid correction techniques. Upper eyelid blepharoplasty may include skin excision with orbital fat modulation as well as ptosis correction and definition of the superior sulcus...

    Dermatologic Surgery

    Banana Leaves As an Alternative Wound Dressing

    Dermatologic Surgery (Dec 2012)

    Background: There is a need for cheap and efficacious wound dressings in developing countries. Banana leaves have been described as an excellent, inexpensive, easily available dressing material in tropical countries. As a natural product, banana leaves are heavily contaminated with various pathogens that must be...

    Comparison of Effectiveness of Electrocautery and Cryotherapy in Partial Matrixectomy After Partial Nail Extraction in the Treatment of Ingrown Nails

    Dermatologic Surgery (Dec 2012)

    Objective: To determine an effective mode of therapy of ingrown nail using two different methods. Methods: Patients with the diagnosis of stage 2 or 3 ingrown nails were included and divided into two groups. In the first group, partial matrixectomy was performed using electrocautery after partial nail extraction; in...

    A Comparative Study of the Efficacy of Endovenous Laser Treatment of the Incompetent Great Saphenous Under General Anesthesia with External Air Cooling with and Without Tumescent Anesthesia

    Dermatologic Surgery (Dec 2012)

    Background: This clinical study reports our experience with endovenous laser treatment (ELT) in which external air cooling is used without classic tumescent anesthesia. Methods: Two hundred thirty-two patients underwent ELT under general sedation. In group A (n = 192), ELT was performed with air cooling but without the...

    Repair of Full-Thickness Alar Defects

    Dermatologic Surgery (Jun 2012)

    Background: A basal cell carcinoma can invade the cartilage in the nasal ala and can reach the nasal vestibule skin. A full-thickness reconstruction of the nasal ala is required to repair the tissue damage after tumor removal. We combined an auricular composite graft with a nasolabial flap to repair the defects in the...

    Treatment-Refractory Actinic Keratoses Successfully Treated Using Simultaneous Combination Topical 5-Fluorouracil Cream and Imiquimod Cream: A Case–Control Study

    Dermatologic Surgery (Jun 2012)

    Background: Most actinic keratoses (AKs) respond to standard treatments, but a subset persist and require further intervention. We report a series of 10 patients with AKs that failed to respond to conventional treatment with cryotherapy and topical monotherapy but responded completely to simultaneous therapy with...

    A modified method using the SonoPrep® ultrasonic skin permeation system for sampling human interstitial fluid is compatible with proteomic techniques

    Dermatologic Surgery (Jun 2012)

    Background: The use of biomarkers in skin is a novel diagnostic tool. Interstitial fluid (ISF) from skin provides a snapshot of proteins secreted at the time of sampling giving insights into the patient's health status. Methods: A minimally invasive technique for the transdermal collection of human ISF proteins. A low...

    Analysis of human skin tissue by millimeter-wave reflectometry

    Dermatologic Surgery (Jun 2012)

    Background/Purpose: Millimeter-wave reflectometry is a potentially interesting technique to analyze the human skin in vivo in order to determine the water content locally in the skin. Purpose of this work is to investigate the possibility of skin-tissue differentiation. In addition, it addresses the influence of the...

    Hyperspectroscopic screening of melanoma on acral volar skin

    Dermatologic Surgery (Jun 2012)

    Background/Purpose: Early detection and proper excision of the primary lesions of melanoma are crucial for reducing melanoma-related deaths. To support the early detection of melanoma, automated melanoma-screening systems have been extensively studied and developed. In this article, a previously reported hyperspectral...

    Epidemiology of Dermatofibrosarcoma Protuberans in Alberta, Canada, from 1988 to 2007

    Dermatologic Surgery (Jun 2012)

    Background: There have only been a few population-based, epidemiologic studies assessing dermatofibrosarcoma protuberans (DFSP). Objective: To assess the epidemiology of DFSP in Alberta, Canada, over a 20-year period. Methods: A population-based, retrospective analysis of all cases of DFSP in Alberta was conducted...

    Diagnostic Utility of Cytokeratin 17 Immunostaining in Morpheaform Basal Cell Carcinoma and for Facilitating the Detection of Tumor Cells at the Surgical Margins

    Dermatologic Surgery (Jun 2012)

    Background: The morpheaform subtype of basal cell carcinoma (BCC) often presents a diagnostic histological challenge, and its true margin may be difficult to determine with accuracy. This tumor may also be difficult to distinguish from other adnexal neoplasms having a benign clinical course. Previous work has shown...

    Dermatology Research and Practice

    Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma?

    Dermatology Research and Practice (Oct 2011)

    Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. Immunotherapy is another targeted option. Ipilimumab, a monoclonal antibody directed to CTLA-4 present...

    RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy

    Dermatology Research and Practice (Oct 2011)

    Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes. In human...

    miRNAs and Melanoma: How Are They Connected?

    Dermatology Research and Practice (Aug 2011)

    miRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation. It is predicted that over 30% of RNAs are regulated by miRNAs. Therefore these molecules are considered essential in the processing of many biological responses, such...

    Diabetes Research and Clinical Practice

    Societal correlates of diabetes prevalence: An analysis across 94 countries

    Diabetes Research and Clinical Practice (Dec 2011)

    Aims: To quantify relationships between societal-level factors and diabetes prevalence and identify potential policy responses. Methods: Using data from International Diabetes Federation, World Health Organization, World Bank, and Food and Agricultural Organization, we extracted recent estimates for country-level...

    Elevated asymmetric dimethylarginine in plasma: An early marker for endothelial dysfunction in non-alcoholic fatty liver disease?

    Diabetes Research and Clinical Practice (Dec 2011)

    Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease. Asymmetric dimethylarginine (ADMA) is a novel marker of endothelial dysfunction and atherosclerosis. We aimed to investigate circulating ADMA concentrations in biopsy proven NAFLD and also to search its association with carotid...

    Diabetes, Obesity and Metabolism

    Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β

    Diabetes, Obesity and Metabolism (Apr 2013)

    Aims: To examine whether protein kinase C (PKC) and associated downstream mechanisms are involved in hyperglycaemia (HG)-evoked blood-brain barrier (BBB) damage. Methods: The activities of total PKC (Peptag assay), NADPH oxidase (lucigenin assay) and matrix metalloproteinase-2 (MMP-2; gelatin zymography) were measured...

    The efficacy and safety of ezetimibe/simvastatin combination compared with intensified lipid-lowering treatment strategies in diabetic subjects with and without metabolic syndrome

    Diabetes, Obesity and Metabolism (Jan 2013)

    Aims: The objective was to assess the consistency of effect of switching to ezetimibe/simvastatin 10/20 mg versus doubling the baseline statin dose (to simvastatin 40 mg or atorvastatin 20 mg) or switching to rosuvastatin 10 mg across subgroups of subjects with (n = 617) and without (n = 191) metabolic syndrome (MetS)....

    Linagliptin monotherapy in type 2 diabetes patients for whom metformin is inappropriate: an 18-week randomized, double-blind, placebo-controlled phase III trial with a 34-week active-controlled extension

    Diabetes, Obesity and Metabolism (Oct 2012)

    Aims: To investigate the efficacy and safety of linagliptin, a dipeptidyl peptidase-4 inhibitor, in type 2 diabetes mellitus (T2DM) patients for whom metformin was inappropriate. Methods: This 1-year double-blind study (ClinicalTrials.gov, NCT00740051) enrolled T2DM patients with inadequate glycaemic control,...

    Modified release terbutaline (SKP1052) for hypoglycaemia prevention: a proof-of-concept study in people with type 1 diabetes mellitus

    Diabetes, Obesity and Metabolism (Sep 2012)

    Aims: In this randomized, single blind, cross-over study 2.5 mg and 5 mg of the modified-release terbutaline formulation (SKP-1052) were compared with conventional immediate-release terbutaline (IRT, 5 mg) and placebo on overnight blood glucose (BG) and hypoglycaemia in 30 subjects with type 1 diabetes mellitus....

    Cardiovascular Risk in the Young Type 1 Diabetes Population with a Low 10-Year, but High Lifetime Risk of Cardiovascular Disease

    Diabetes, Obesity and Metabolism (Sep 2012)

    Diabetes mellitus is associated with excess cardiovascular mortality that is evident in all age groups, but is most pronounced in young people with type 1 diabetes. Cardiovascular risk estimation models generally estimate the probability of future events over a 10-year time horizon. Due to the dependency on age,...

    The safety and efficacy of adding once-daily insulin detemir to oral hypoglycaemic agents in patients with type 2 diabetes in a clinical practice setting in 10 countries

    Diabetes, Obesity and Metabolism (Aug 2012)

    Aims: Evaluate the safety and efficacy of once-daily insulin detemir initiated in routine clinical practice in patients with type 2 diabetes mellitus inadequately controlled with oral hypoglycaemic agents (OHAs). Methods: This large observational study was conducted in 10 countries. Adverse event data (including...

    Impact of diabetes duration and chronic pancreatitis on the association between type 2 diabetes and pancreatic cancer risk

    Diabetes, Obesity and Metabolism (Aug 2012)

    Aim: To examine the impact of diabetes duration, chronic pancreatitis and other factors on pancreatic cancer risk. Methods: This retrospective cohort study using the UK General Practice Research Database compared pancreatic cancer incidence and risk in patients with type 2 diabetes mellitus (T2DM) versus patients...

    Investigation of intracellular signalling cascades mediating stimulatory effect of a Gymnema sylvestre extract on insulin secretion from isolated mouse and human islets of Langerhans

    Diabetes, Obesity and Metabolism (Aug 2012)

    Aim: Traditional plant-based remedies such as Gymnema sylvestre (GS) extracts have been used to treat diabetes mellitus for many centuries. We have shown previously that a novel GS extract, OSA®, has a direct effect on insulin secretion but its mode of action has not been studied in detail Thus this study investigated...

    Safety, pharmacokinetics and pharmacodynamics of multiple-ascending doses of the novel glucokinase activator AZD1656 in patients with type 2 diabetes mellitus

    Diabetes, Obesity and Metabolism (Jul 2012)

    Aims: To assess the safety, pharmacokinetics and pharmacodynamics of multiple-ascending doses of the novel glucokinase activator AZD1656 in patients with type 2 diabetes mellitus (T2DM). Methods: This randomized, single-blind, placebo-controlled, monotherapy study was carried out in two parts. In part A, 32 patients...

    Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial

    Diabetes, Obesity and Metabolism (Jul 2012)

    Aims: Evaluate anti-interleukin-1β (IL-1β) antibody, canakinumab, in patients with type 2 diabetes and impaired glucose tolerance (IGT) in whom hyperglycaemia may trigger IL-1β-associated inflammation leading to suppressed insulin secretion and β-cell dysfunction. Methods: This 4-week, parallel-group study randomized...

    Comparison of safety and tolerability with continuous (exenatide once weekly) or intermittent (exenatide twice daily) GLP-1 receptor agonism in patients with type 2 diabetes

    Diabetes, Obesity and Metabolism (Jul 2012)

    Aims: Exenatide is a glucagon-like peptide-1 receptor agonist shown to improve glycaemic control in patients with type 2 diabetes (T2DM). Intermittent exenatide exposure is achieved with the twice-daily formulation (ExBID), while the once-weekly formulation (ExQW) provides continuous exenatide exposure. This...

    Factors associated with injection omission/non-adherence in the Global Attitudes of Patients and Physicians in Insulin Therapy study

    Diabetes, Obesity and Metabolism (Jul 2012)

    Aim: To examine factors associated with insulin injection omission/non-adherence on a global basis. Methods: Telephone survey of 1530 insulin-treated adults with self-reported diabetes (110 type 1 and 1420 type 2) in China, France, Japan, Germany, Spain, Turkey, UK or USA. Participants had a mean age of ~60 years, ~15...

    Longer term safety of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes mellitus: systematic review and meta-analysis

    Diabetes, Obesity and Metabolism (May 2012)

    Dipeptidyl peptidase-4 (DPP-4) inhibitors are oral antidiabetic agents that hold the potential of slowing the progress of type 2 diabetes mellitus. Their long-term safety is still a subject of debate. A systematic review of randomized, controlled trials was undertaken to comprehensively profile the safety of chronic...

    Insulinemia and the risk of breast cancer and its relapse

    Diabetes, Obesity and Metabolism (May 2012)

    A fairly large body of evidence has shown that insulin is a tumour-promoting agent, especially for breast cancer. High circulating and microenvironmental levels of insulin may directly increase the risk of breast cancer via the activation of cognate receptors expressed on normal and cancer cells and indirectly be...

    Diabetes/Metabolism Research and Reviews

    Prevalence of overweight, obesity and metabolic syndrome components in children, adolescents and young adults with Type 1 Diabetes

    Diabetes/Metabolism Research and Reviews (May 2014)

    Background:

    We aimed to determine the prevalence of overweight and obesity among children, adolescents and young adults with Type 1 Diabetes (T1DM), and to assess the prevalence of the metabolic syndrome (MetS) and its components.

    Methods:

    The study cohort comprised 326 (168 females) consecutive...

    Effects of exenatide on obesity and NAFLD with elevated liver enzymes in patients with Type 2 Diabetes

    Diabetes/Metabolism Research and Reviews (May 2014)

    Background:

    The purpose of this study was to evaluate the advantages of exenatide (Exe) treatment on obesity and non–alcoholic fatty liver disease (NAFLD) with elevated liver enzymes in patients with type 2 diabetes (T2D).

    Methods:

    A total of 60 newly diagnosed patients with obesity, NAFLD...

    Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis

    Diabetes/Metabolism Research and Reviews (Nov 2013)

    Obesity is considered to be a chronic inflammatory state in which the dysfunction of adipose tissue plays a central role. The adipokines, which are cytokines secreted by adipose tissue, are key links between obesity and related diseases such as metabolic syndrome (MetS) and atherosclerosis. Lipocalin-2 (LCN2) and...

    Diabetes in pregnancy among indigenous women in Australia, Canada, New Zealand and the United States: a systematic review of the evidence for screening in early pregnancy

    Diabetes/Metabolism Research and Reviews (May 2013)

    Recently proposed international guidelines for screening for gestational diabetes mellitus (GDM) recommend additional screening in early pregnancy for sub-populations at a high risk of type 2 diabetes mellitus (T2DM), such as indigenous women. However, there are criteria that should be met to ensure the benefits...

    Demographic and personal factors associated with metabolic control and self-care in youth with type 1 diabetes: a systematic review

    Diabetes/Metabolism Research and Reviews (May 2013)

    Optimal use of recent technological advances in insulin delivery and glucose monitoring remain limited by the impact of behaviour on self-care. In recent years, there has been a resurgence of interest in psychosocial methods of optimizing care in youth with type 1 diabetes. We therefore sought to examine the literature...

    Antidepressant use and new-onset diabetes: a systematic review and meta-analysis

    Diabetes/Metabolism Research and Reviews (May 2013)

    Antidepressant use has been linked to new-onset diabetes. However, the existing literature on this relationship has yielded inconsistent findings. The primary objective of this study was to systematically synthesize the literature on the relationship between antidepressant use and new-onset diabetes using...

    Common mechanisms of dysfunctional adipose tissue and obesity-related cancers

    Diabetes/Metabolism Research and Reviews (May 2013)

    The relation between cancer and metabolic disorders was recognized several decades ago, but the underlying mechanisms involved in cancer development and progression remain obscure. In the last years, many groups have been studying systemic adipose tissue markers in cancer patients. However, few consistent results were...

    Dual effect of advanced glycation end products in pancreatic islet apoptosis

    Diabetes/Metabolism Research and Reviews (May 2013)

    Background: Loss of β-cell function hastens deterioration of metabolic control in type 2 diabetes patients. Besides amyloid deposit and glucolipotoxicity, advanced glycation end products (AGEs) acting through their receptors (RAGE) seem to contribute to this process by promoting islet apoptosis. In order to investigate...

    Ferritin levels and risk of type 2 diabetes mellitus: an updated systematic review and meta-analysis of prospective evidence

    Diabetes/Metabolism Research and Reviews (May 2013)

    Background: Emerging evidence suggests that a strong link that exists between elevated baseline body iron stores and high risk of incident type 2 diabetes mellitus (T2DM) in general populations, but the precise magnitude of the associations remains uncertain. Methods: We conducted a systematic review and meta-analysis...

    Low clonogenic potential of circulating angiogenic cells is associated with lower density of capillaries in skeletal muscle in patients with impaired glucose tolerance

    Diabetes/Metabolism Research and Reviews (May 2013)

    Background: Reduced density of capillaries in skeletal muscle can limit insulin, glucose, and oxygen supply to the muscle, thereby contributing to worsening metabolism in older adults. The lower skeletal muscle capillarization in impaired glucose tolerance (IGT) may partially be due to circulating angiogenic cell...

    Cell-specific insulin resistance: implications for atherosclerosis

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    Insulin resistance is increasingly acknowledged as an independent risk factor for cardiovascular disease. Despite this, our understanding of the cellular and molecular mechanisms that might account for this relationship remain incompletely understood. A key challenge has been in distinguishing between a ‘whole-body’...

    The role of glycogen synthase in the development of hyperglycemia in type 2 diabetes – ‘To store or not to store glucose, that's the question’

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    This review deals with the role of glycogen storage in skeletal muscle for the development of insulin resistance and type 2 diabetes. Specifically, the role of the enzyme glycogen synthase, which seems to be locked in its hyperphosphorylated and inactivated state, is discussed. This defect seems to be secondary to...

    Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    Background: ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC...

    The relation among NGF, EGF and insulin is important for triggering pancreatic β cell apoptosis

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    Background: Nerve growth factor (NGF) is a well-known mediator for maintaining the survival of neurons, while recent studies report that its absence induces apoptosis in cultured β cells of humans and rats. However, its relationship with other growth factors that have important roles in the survival and function of β...

    Effect of exercise intensity and duration on capillary glucose responses in pregnant women at low and high risk for gestational diabetes

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    Background: Exercise may influence glucose metabolism during pregnancy. We examined the effect of exercise intensity and duration on capillary glucose responses in pregnant women at low and high risk for gestational diabetes mellitus (GDM) who followed a modified GDM meal plan. Methods: Randomization occurred at study...

    Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    Background: The association between small ubiquitin-like modifier 4 (SUMO4) gene polymorphism and type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) has been investigated in several studies. We conducted a meta-analysis to evaluate the association of SUMO4 gene polymorphism with T1DM and T2DM...

    Estimating risk factors and perinatal outcomes for gestational diabetes and impaired glucose tolerance in teen mothers

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    Background: Our objective was to identify potentially modifiable risk factors and outcomes for gestational diabetes and impaired glucose tolerance in a contemporary American teen population. Methods: We conducted a retrospective cohort analysis of all teenage deliveries (≤18 years old) at one institution over a 4-year...

    Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey

    Diabetes/Metabolism Research and Reviews (Nov 2012)

    Background: Neuropad is a novel indicator test for sudomotor dysfunction, which has not been validated as a screening tool in a population-based study. This study aimed to evaluate the utility of Neuropad as a screening tool for distal symmetric polyneuropathy among elderly subjects with diabetes and pre-diabetes in...

    The association studies of ADIPOQ with type 2 diabetes mellitus in Chinese populations

    Diabetes/Metabolism Research and Reviews (Oct 2012)

    Adiponectin, which is secreted by the white adipose tissue, plays an important role in type 2 diabetes mellitus (T2DM) and its complications. Since 2002, many investigators explored the association between ADIPOQ single nucleotide polymorphisms and T2DM in different ethnic populations from different regions. In China,...

    Self-monitoring of blood glucose (SMBG) improves glycemic control in oral hypoglycemic agents (OHA)-treated type 2 diabetes (SMBG-OHA Study)

    Diabetes/Metabolism Research and Reviews (Sep 2012)

    Background: We conducted a clinical research study to determine the effect of SMBG on glycemic control and the value of a putatively less painful blood sampling technique on SMBG in OHA-treated type 2 diabetes (T2D) patients because SMBG was not broadly applied in non-insulin-treated patients in Japan. Methods: One...

    Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D)

    Diabetes/Metabolism Research and Reviews (Sep 2012)

    Background: High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes (T2D). Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients....

    Diabetic Medicine

    Antibodies to islet cell autoantigens, rotaviruses and/or enteroviruses in cord blood and healthy mothers in relation to the 2010–2011 winter viral seasons in Israel: a pilot study

    Diabetic Medicine (Feb 2014)

    Aims:

    To determine whether antivirus and/or islet cell antibodies can be detected in healthy pregnant mothers without diabetes and/or their offspring at birth in two winter viral seasons.

    Methods:

    Maternal and cord blood sera from 107 healthy pregnant women were tested for islet cell autoantibodies...

    Incidence of Type 2 diabetes among occupational classes in Sweden: a 35–year follow–up cohort study in middle–aged men

    Diabetic Medicine (Feb 2014)

    Aims:

    To assess if low occupational class was an independent predictor of Type 2 diabetes in men in Sweden over a 35–year follow–up, after adjustment for both conventional risk factors and psychological stress.

    Methods:

    A random population–based sample of 6874 men aged 47–56...

    Epidemiology of childhood Type 1 diabetes in Taiwan, 2003 to 2008

    Diabetic Medicine (Feb 2014)

    Aims:

    To report the annual incidence rate and the socio–demographic and clinical characteristics of childhood Type 1 diabetes in Taiwan in the period 2003–2008.

    Methods:

    A total of 1306 incident cases of childhood (0–14 years) Type 1 diabetes were identified from Taiwan's National...

    Symptom burden and its association with change in glucose metabolism status over a 7–year period: the Hoorn Study

    Diabetic Medicine (Feb 2014)

    Aims:

    To study symptom burden among older people and its associations with change in glucose metabolism status over a 7–year period.

    Methods:

    We conducted a prospective population–based cohort study among 397 older people. We used the revised Diabetes Symptom Checklist to assess symptom...

    Blood glucose levels in children with Type 1 diabetes attending a residential diabetes camp: a 2-year review

    Diabetic Medicine (Nov 2012)

    Aims: The objective of this retrospective analysis of blood glucose values at a week-long residential summer camp for children with Type 1 diabetes was to provide experiential data to reinforce current summer camp guidelines and to determine if specific interventions implemented between 2009 and 2010 were effective in...

    Characterizing the transition from paediatric to adult care among emerging adults with Type 1 diabetes

    Diabetic Medicine (Nov 2012)

    Aims: The goals of the study were to describe the transition of youth with Type 1 diabetes from paediatric to adult healthcare services, examine the link of this transition with self care and glycaemic control, and distinguish youth who received medical treatment from different physicians in terms of demographic and...

    Family history of Type 1 diabetes affects insulin secretion in patients with ‘Type 2’ diabetes

    Diabetic Medicine (Nov 2012)

    Aims: The aim was to evaluate the impact of family history of diabetes on the phenotype of patients diagnosed with Type 2 diabetes and the frequency of susceptibility genotypes. Methods: Patients with Type 2 diabetes with family history for both Type 1 and Type 2 diabetes (FHMIX, n = 196) or Type 2 diabetes only (FHT2,...

    The impact of regional deprivation and individual socio-economic status on the prevalence of Type 2 diabetes in Germany. A pooled analysis of five population-based studies

    Diabetic Medicine (Nov 2012)

    Aim: Our objective was to test the hypothesis that the prevalence of Type 2 diabetes increases with increasing regional deprivation even after controlling for individual socio-economic status. Methods: We pooled cross-sectional data from five German population-based studies. The data set contained information on n = 11...

    Intensification of diabetes medication and risk for 30-day readmission

    Diabetic Medicine (Nov 2012)

    Aim: To examine the association of in-hospital diabetes regimen intensification with subsequent 30-day risk for unplanned readmission/emergency department admission. Methods: We retrospectively studied 1949 adults with Type 2 diabetes receiving primary care within an academic health network admitted to the hospital...

    Identifying risk and preventing progression to Type 2 diabetes in vulnerable and disadvantaged adults: a pragmatic review

    Diabetic Medicine (Sep 2012)

    Aim: To identify effective approaches to recognize diabetes risk and prevent progression to Type 2 diabetes in vulnerable groups, whose diabetes risk may be difficult to identify or manage. Methods: UK-based interventions that assess diabetes risk and/or target known risk factors were identified through four main...

    The burden of diabetes mellitus and impaired fasting glucose in an urban population of Sri Lanka

    Diabetic Medicine (Sep 2012)

    Aims: To describe the burden of diabetes mellitus and impaired fasting glucose in middle-aged residents (35–64 years) in an urban area of Sri Lanka. Methods: A cross-sectional survey was conducted in the Ragama Medical Officer of Health area, from which 2986 participants (1349 men and 1637 women) were randomly selected...

    Vibration thresholds are increased at low frequencies in the sole of the foot in diabetes a novel multi-frequency approach

    Diabetic Medicine (Sep 2012)

    Aims: To evaluate multi-frequency tactilometry as a method to measure vibrotactile sense in the sole of the foot in subjects with diabetes. Methods: Vibration thresholds were investigated at five frequencies (8, 16, 32, 64 and 125 Hz) at three sites (first and fifth metatarsal heads and heel) in the sole of the foot in...

    The impact of culturally competent diabetes care interventions for improving diabetes-related outcomes in ethnic minority groups: a systematic review

    Diabetic Medicine (Sep 2012)

    Aim: To examine the evidence on culturally competent interventions tailored to the needs of people with diabetes from ethnic minority groups. Methods: MEDLINE (NHS Evidence), CINAHL and reference lists of retrieved papers were searched from inception to September 2011; two National Health Service specialist libraries...

    Vitamin supplementation and blood pressure in Type 2 diabetes

    Diabetic Medicine (Sep 2012)

    Aims: Vitamin D levels are inversely related to blood pressure. Given that low sun exposure can create a greater reliance on dietary sources of vitamin D, we aimed to determine whether dietary vitamin D and blood pressure associations differ between periods of low and high sun exposure. Methods: Dietary intake, vitamin...

    Monotherapy with the once-weekly GLP-1 analogue dulaglutide for 12 weeks in patients with Type 2 diabetes: dose-dependent effects on glycaemic control in a randomized, double-blind, placebo-controlled study

    Diabetic Medicine (Sep 2012)

    Aims: Evaluate dose-dependent effects of once-weekly dulaglutide, a glucagon-like peptide-1 analogue, on glycaemic control in patients with Type 2 diabetes treated with lifestyle measures with or without previous metformin. Methods: This 12-week, double-blind, placebo-controlled, dose–response trial randomized 167...

    Number and sex ratio of children and impact of parental diabetes in individuals with Type 1 diabetes

    Diabetic Medicine (Sep 2012)

    Objective: To assess the number and sex ratio of children in individuals with Type 1 diabetes mellitus and the influence of parental diabetes on age at onset of Type 1 diabetes in our cohort. Methods: In a cross-sectional study in a German region comprising 350 000 inhabitants, 697 subjects with Type 1 diabetes (364...

    Decreased GAD65-specific Th1/Tc1 phenotype in children with Type 1 diabetes treated with GAD-alum

    Diabetic Medicine (Sep 2012)

    Aim: The balance between T helper cell subsets is an important regulator of the immune system and is often examined after immune therapies. We aimed to study the immunomodulatory effect of glutamic acid decarboxylase (GAD) 65 formulated with aluminium hydroxide (GAD-alum) in children with Type 1 diabetes, focusing on...

    The impact of insulin administration during the mixed meal tolerance test

    Diabetic Medicine (Sep 2012)

    Aims: The mixed meal tolerance test is the gold standard measure of endogenous insulin secretion. Practical issues limit the routine clinical use of this test, including omitting insulin prior to the ingestion of a high-carbohydrate liquid mixed meal, which can result in marked hyperglycaemia. We aimed to assess...

    High normal HbA1c levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8)

    Diabetic Medicine (Sep 2012)

    Aims: We aimed to characterize the association of insulin resistance, impaired insulin secretion and β-cell dysfunction in relation to HbA1c levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes. Methods: This cross-sectional study included 1444 individuals without a history of...

    Type 1 diabetes in pre-school children – long-term metabolic control, associated autoimmunity and complications

    Diabetic Medicine (Sep 2012)

    Aims: To identify clinical characteristics and co-morbidity rates of children diagnosed with Type 1 diabetes mellitus at younger than 6 years of age. Methods: Data were obtained from a retrospective chart review of 103 patients diagnosed with Type 1 diabetes at younger than 6 years (study group) and 220 patients at...

    Urinary markers of renal inflammation in adolescents with Type 1 diabetes mellitus and normoalbuminuria

    Diabetic Medicine (Sep 2012)

    Aims: Patients with the highest albumin:creatinine ratio within the normal range are at an increased risk for developing microalbuminuria. The mechanistic basis for this is unknown, but may be related to renal inflammation. Our goal was to characterize the urinary excretion of cytokines/chemokines in normoalbuminuric...

    Facilitating children’s contributions in clinic? Findings from an in-depth qualitative study with children with Type 1 diabetes

    Diabetic Medicine (Sep 2012)

    Aims: There is a policy drive for children to contribute more directly in clinic visits. However, this has yet to be routinely achieved in practice and relatively little is known to date about younger children’s views of their illness and care. This in-depth qualitative study set out to explore the experiences of...

    Insulin initiation and management in people with Type 2 diabetes in an ethnically diverse population: the healthcare provider perspective

    Diabetic Medicine (Sep 2012)

    Aim: To explore barriers to prescribing of insulin, particularly delays in initiation, from the perspective of healthcare professionals involved in managing Type 2 diabetes in a multi-ethnic setting. Methods: The study was carried out in a UK population with high numbers of people of South Asian (mainly Indian) origin....

    Effect of primary percutaneous coronary intervention on stress hyperglycaemia in myocardial infarction

    Diabetic Medicine (Sep 2012)

    Aim: To measure the effect of primary percutaneous coronary intervention on stress hyperglycaemia induced by ST segment elevation myocardial infarction. Methods: We measured blood glucose before primary percutaneous coronary intervention and 1 h after intervention in all patients presenting with ST segment elevation...

    Costs of paediatric diabetes care in Germany: current situation and comparison with the year 2000

    Diabetic Medicine (Sep 2012)

    Aims: To estimate direct costs of paediatric Type 1 diabetes care and associated factors in Germany for the year 2007 and to compare results with the costs for the year 2000. Methods: Our study includes clinical data and charges for any diabetes-related health care service of 14 185 continually treated subjects with...

    Plasma C-peptide concentration in women with Type 1 diabetes during early and late pregnancy

    Diabetic Medicine (Sep 2012)

    Aims: There are previous suggestions of increased C-peptide concentration in women with Type 1 diabetes during pregnancy. Our aim was to re-evaluate the hypothesis of a pregnancy-induced increase by measuring plasma C-peptide concentration in women with stable blood glucose control under standardized fasting and...

    How does physical activity and fitness influence glycaemic control in young people with Type 1 diabetes?

    Diabetic Medicine (Sep 2012)

    Aims: To assess physical activity and fitness levels of young people with Type 1 diabetes compared with siblings without diabetes, and to investigate the association between physical activity, physical fitness and glycaemic control (HbA1c) in those young people with diabetes. Methods: The study consisted of 97 young...

    Effectiveness of peer-led self-management coaching for patients recently diagnosed with Type 2 diabetes mellitus in primary care: a randomized controlled trial

    Diabetic Medicine (Sep 2012)

    Aims: To study the effectiveness of a peer-led self-management coaching intervention in recently diagnosed patients with Type 2 diabetes. Methods: Randomized controlled trial of recently diagnosed patients with Type 2 diabetes from 54 participating general practices. The intervention group received three home visits by...

    Diabetologia

    Peri–conception hyperglycaemia and nephropathy are associated with risk of congenital anomaly in women with pre–existing diabetes: a population–based cohort study.

    Diabetologia (Apr 2012)

    Aims:

    The aim of this study was to quantify the risk of major congenital anomaly, and to assess the influence of peri–conception HbA(1c) and other clinical and socio–demographic factors on the risk of congenital anomaly occurrence in offspring of women with type 1 and type 2 diabetes diagnosed...

    Diagnostic Cytopathology

    Occupational exposures to aluminum and iron and risk of lung epithelium atypia in sudan

    Diagnostic Cytopathology (Dec 2012)

    This study investigated the risk of lung cytological atypical changes in regards to occupational exposure to aluminum and iron. Detailed job histories were elicited from 130 incident cases with confirmed exposure to aluminum (50) or iron (80) and 157 population controls (nonexposed). Cytological atypia in sputum...

    Digestive and Liver Disease

    Role of microsatellite instability in the management of colorectal cancers

    Digestive and Liver Disease (Nov 2012)

    Microsatellite instability is the consequence of a deficient mismatch repair system. It has a key role in the diagnostic strategy of Lynch syndrome, where tumours are all characterized by the presence of this phenotype. Microsatellite instability is therefore essential in the selection of colorectal cancer patients in...

    Sixty- versus thirty-seconds papillary balloon dilation after sphincterotomy for the treatment of large bile duct stones: A randomized controlled trial

    Digestive and Liver Disease (Nov 2012)

    Background: Endoscopic biliary sphincterotomy followed by endoscopic papillary balloon dilation is a promising method for large stones. However, there are no data on the optimal duration of papillary balloon dilation after a biliary sphincterotomy. Aims: To compare the effectiveness and complications of the endoscopic...

    Anti-TNF-alpha treatments and obstructive symptoms in Crohn's Disease: A prospective study

    Digestive and Liver Disease (Nov 2012)

    Background: The development of symptomatic strictures in Crohn's Disease after anti-Tumour Necrosis Factor-α antibodies is undefined. Aim: To assess, in a prospective longitudinal study, the frequency of sub/obstructions in Crohn's Disease patients after treatment with Infliximab or Adalimumab. Changes of small bowel...

    Diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small-bowel disease: Results of the Italian multicentre study

    Digestive and Liver Disease (Nov 2012)

    Background: Limited data are available on the clinical impact of single balloon enteroscopy. Aims: To evaluate the diagnostic and therapeutic yield of single balloon enteroscopy in patients with suspected small bowel disease. Methods: Data on patients with suspected small bowel disease based on non-invasive imaging,...

    Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma

    Digestive and Liver Disease (Nov 2012)

    Hepatocellular carcinoma and cholangiocarcinoma are primary liver cancers, both represent a growing challenge for clinicians due to their increasing morbidity and mortality. In the last few years a number of in vivo models of hepatocellular carcinoma and cholangiocarcinoma have been developed. The study of these models...

    The impact of patient and tumour baseline characteristics on the overall survival of patients with advanced hepatocellular carcinoma treated with sorafenib

    Digestive and Liver Disease (Nov 2012)

    Background: Impact of patient and tumour baseline characteristics on the overall survival is not well characterized in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Aims/Methods: Univariate/multivariate analyses were conducted to identify retrospectively the impact of baseline...

    Beneficial effect of splenic artery ligation on bacterial translocation after major liver resection in rats

    Digestive and Liver Disease (Nov 2012)

    Objective: In major liver resection, bacterial translocation appears to be an important mechanism in the pathogenesis of spontaneous infection. This study was designed to investigate the effects of splenic artery ligation on bacterial translocation after major liver resection. Materials and methods: Rats were divided...

    Long-term outcome after extensive intestinal resection for chronic radiation enteritis

    Digestive and Liver Disease (Nov 2012)

    Introduction: Management of chronic radiation enteritis is often controversial, particularly due to the risk of short bowel syndrome. Methods: One hundred and seven chronic radiation enteritis patients with short bowel syndrome were studied retrospectively between 1980 and 2009. Survival and home parenteral nutrition...

    Diseases of the Esophagus

    Epidemiology of esophageal atresia

    Diseases of the Esophagus (May 2013)

    Esophageal atresia (EA) is a rare congenital malformation consisting of a lack of continuity between the upper and lower esophageal pouches, frequently associated with tracheoesophageal fistula. The prevalence of such rare abnormalities is established by global birth surveillance programs over the world. EUROCAT is a...

    Genetic and cellular mechanisms of the formation of esophageal atresia and tracheoesophageal fistula

    Diseases of the Esophagus (May 2013)

    Foregut separation involves dynamic changes in the activities of signaling pathways and transcription factors. Recent mouse genetic studies demonstrate that some of these pathways interact with each other to form a complex network, leading to a unique dorsal-ventral patterning in the early foregut. In this review, it...

    Thoracoscopic repair of esophageal atresia and tracheoesophageal fistula in neonates, first decade's experience

    Diseases of the Esophagus (May 2013)

    The first thoracoscopic esophageal atresia with tracheoesophageal fistula (EATEF) repair was performed in March of 2000. This report evaluates the results and evolution of the technique in a single surgeons' experience after the first decade of thoracoscopic EATEF repair. From March 2000 to September 2012, 52...

    Thoracotomy for repair of esophageal atresia: not as bad as they want you to think!

    Diseases of the Esophagus (May 2013)

    Is it outdated now to do a thoracotomy to repair esophageal atresia (EA)? Our practices and the literature on the subject of thoracoscopic and open thoracotomy repair of EA were reviewed, seeking answers to the following questions: Is it correct to compare the new thoracoscopic approach for the repair of EA against the...

    Long-gap esophageal atresia: traction-growth and anastomosis – before and beyond

    Diseases of the Esophagus (May 2013)

    Long-gap esophageal atresia (LGEA) is still a major surgical challenge. Options for esophageal reconstruction include the use of native esophagus or esophageal replacement with stomach, colon, or small intestine. Nonetheless, there is a consensus among most pediatric surgeons that the preservation of the native...

    Diagnosis and surgical management of recurrent tracheoesophageal fistulas

    Diseases of the Esophagus (May 2013)

    Recurrent tracheoesophageal fistula (TEF) is difficult to diagnose and even more difficult to repair. The key to the diagnosis is an adequate contrast study and bronchoscopy. The key to the repair is complete separation of the esophagus from the trachea, with the placement of viable tissue between the two suture lines....

    Refractory strictures post-esophageal atresia repair: what are the alternatives?

    Diseases of the Esophagus (May 2013)

    Esophageal strictures remain the most frequent complication after esophageal atresia (EA) repair despite refinements in operative techniques. With an incidence of anastomotic stricture between 8% and 49%, EA is the most frequent cause of benign esophageal stricture in children. The mainstay of treatment for esophageal...

    Dynamic esophageal stents

    Diseases of the Esophagus (May 2013)

    Esophageal stenting represents a new strategy in the treatment of resistant or recurrent stenosis that obviates the need for multiple dilations. Our custom dynamic stent (DS) improves esophageal motility unlike the widespread self-expandable plastic or metallic esophageal stents. The DS allows food and secretions to...

    Psychological impact of esophageal atresia: review of the research and clinical evidence

    Diseases of the Esophagus (May 2013)

    Esophageal atresia (EA) occurs in one out of 2500 to 4500 live births. As the vast majority of infants are now surviving neonatal corrective surgery, the focus has shifted from mortality to morbidity associated with EA. However, little is known about its psychological morbidity. This paper synthesizes research and...

    Anti-reflux surgery for patients with esophageal atresia

    Diseases of the Esophagus (May 2013)

    Gastroesophageal reflux (GER) is almost constant in esophageal atresia and tracheoesophageal fistula (EA/TEF). These patients resist medical treatment and require antireflux surgery quite often. The present review examines why this happens, the long-term consequences of GER and the main indications and results of...

    Esophageal dysmotility: characterization and pathophysiology

    Diseases of the Esophagus (May 2013)

    Esophageal dysmotility is a considerable long-term issue in patients born with esophageal atresia (EA). To better characterize it, the normal esophageal motility is briefly reviewed with emphasis on the