Kevin Rooney, Consultant in Intensive Care Medicine and Professor of Care Improvement, School of Health, Nursing and Midwifery, University of the West of Scotland, Paisley, UK
A 32-year-old asthmatic, pregnant female at 24 weeks gestation presented to the antenatal clinic with a four-day history of fever, malaise, productive cough and worsening shortness of breath. On examination she was short of breath at rest, with a respiratory rate of 36 breaths/min, and was unable to speak in sentences.
Oni Choudhury, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
A 62-year-old woman presented with a 2-3-month history of breathlessness, non-productive cough, weight loss, lethargy and ankle oedema. Her exercise tolerance was limited to 50 yards by breathlessness.
The current update addresses issues around decision-making and referral thresholds for surgery, and..
The objective of this guideline is to provide healthcare professionals with clear guidance on the..
After completing this module you should know the common causes of mucocutaneous lesions in patients with HIV infection. You should know how to recognise such lesions and, where appropriate, how...
This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the management of allergic rhinoconjunctivitis and other...
This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the risks and benefits of allergen immunotherapy...
Rheumatoid arthritis (RA) is the most common chronic inflammatory arthritis in adults. Monitoring of disease activity is based on Disease Activity Score 28 (DAS 28). There are also validated questionnaires for self-assessment of the disease by the patient. Grip strength measured using a digitized sensor used by the..
Main Objective : To evaluate the correlation between the measurement of grip strength in the dominant hand measured by a digital sensor and activity of RA assessed by DAS 28
Secondary objective : Evaluate the correlation between grip strength of the dominant hand and :
- scores of fatigue and pain (VAS and FACIT)
- the self-assessment scores known in RA : functional index Health Assessment Questionnaire (HAQ) and scores of activity RAPID3 and RADAI5.
It is a cross-sectional study involving 150 patients followed in our department for RA. Grip strength of the dominant hand will be measured by a digitalized sensor during a single visit integrating into the routine monitoring of patients.
A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Subjects and Patients With Plaque Psoriasis17-07-2014
This study is a phase I, randomised, double blind (sponsor unblinded), placebo-controlled, single ascending dose study GSK2831781 administered by IV. GSK2831781 is a humanized Antibody Dependent Cell Cytotoxicity (ADCC) enhanced monoclonal afucosylated antibody that is specific to the Lymphocyte Activation Gene-3..