Immunology Topic Homepage

CSU Knowledge Centre

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The Chronic Spontaneous Urticaria (CSU) Knowledge Centre has been developed to address the current lack of early diagnosis of this condition. Urticaria is more common than previously thought and studies suggest chronic urticaria affects up to 1% of the population at any given time with CSU responsible for two-thirds of these cases.

Allergists, immunologists, dermatologists and other healthcare professionals involved in the management of CSU will find a range of content to support you in effectively diagnosing and treating the condition.

In this resource, you will find a disease overview, symposia highlights platform, video channel and additional resources including an events calendar and useful external links.

Psoriasis Knowledge Centre

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Psoriasis is a chronic inflammatory disease affecting approximately 2% of the world’s population. The Psoriasis Knowledge Centre provides dermatologists, family medicine doctors and other healthcare professionals with relevant information including epidemiology, pathophysiology, diagnosis and more.

A treatment section reviews the established treatments available for psoriasis and considers their modes of action, available clinical data and place in the therapeutic pathway.

Rheumatology Trends

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Rheumatoid Arthritis (RA) is a chronic, systemic inflammatory autoimmune disease that affects up to 1% of the adult population across the developing world, including more than 1 million people in the US alone. As a result, RA represents the world’s biggest market for drug treatments, aside from oncology. Currently this market is dominated by two categories of treatment: non-steroidal anti-inflammatory drugs (NSAIDs), and biologic disease-modifying anti-rheumatic drugs (DMARDs). The gold standard of treatment has been an older oral DMARD methotrexate (MTX) which is included in most combination therapies but it is beset by unwelcome side-effects. Now the leading DMARDs target tumour necrosis factor (TNF), a key inflammatory mediator. These have had a major impact on outcomes, due to improved tolerability and efficacy

Clinical Case Studies

HIV Seroconversion

Infection: HIV Infection

Antonia Ho, Specialist Registrar in Infectious Diseases, Gartnavel General Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK

Case History
A 29-year-old man was admitted with a week's history of general malaise accompanied by severe myalgia, abdominal pain, diarrhoea, headache, dry cough and swelling and redness of his eyes. He was a heavy drinker, and had fallen into the river Clyde two weeks previously while inebriated.

Sickle Cell Lung Disease

Respiratory Medicine & Allergy: Pulmonary Vascular Diseases

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK
Boris Lams, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
Christopher Kosky, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 40-year-old man with known homozygous (HbSS) sickle cell disease (SCD) presented to the emergency department with a three-day history of cough, fever and sweats. He denied any chest pain.

Latest News

Medical Videos

An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System
An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells

Recent Drug Updates

Medical Journal Abstracts on Immunology

Low expression of circulating microRNA-328 is associated with poor prognosis in patients with acute myeloid leukemia.

Fri 17 Jul 2015 -  Low expression of circulating microRNA-328 is associated with poor prognosis in patients with acute myeloid leukemia.

Background: Dysregulation of circulating miR-328 has been identified in several tumors and is associated with prognosis of patients. However, the expression pattern of miR-328 and the impact on ...

Z-BeEAM (Ibritumomab tiuxetan, Bendamustine, Etoposide, Cytarabine, Melphalan) before autologous stem cell transplantation is safe and efficient for refractory large B-cell lymphoma.

Sat 04 Jul 2015 -  Z-BeEAM (Ibritumomab tiuxetan, Bendamustine, Etoposide, Cytarabine, Melphalan) before autologous stem cell transplantation is safe and efficient for refractory large B-cell lymphoma.

BACKGROUND: Refractory or relapsed large B-cells lymphoma are usually treated with a high dose chemotherapy regimen followed by an autolougous stem cells transplantation. BEAM (carmustine, ...

Medical Images

T1-weighted (top) Grase (bottom) MRIs
T1-weighted (top) Grase (bottom) MRIs
Lemierre's Disease
Lemierre's Disease
Diffuse hyperintensity signal
Diffuse hyperintensity signal
Single large left posterior fossa lesion
Single large left posterior fossa lesion
Allergic Bronchopulmonary Aspergillosis
Allergic Bronchopulmonary Aspergillosis
Hartford nomogram
Hartford nomogram
Metavir stage 0 (F0)
Metavir stage 0 (F0)
Osteoporosis
Osteoporosis
Upper lobe infiltrates
Upper lobe infiltrates
Aspiration Syndrome - radiograph
Aspiration Syndrome - radiograph

Clinical Guidelines

Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care

Feb 2015

Key aspects of this guideline include establishing a diagnosis; referral into secondary care only..

... after identification of 'red flags' (symptoms and/or features that may be caused by another condition that needs investigation); providing lifestyle advice; drug and psychological interventions; and referral and follow-up.

Guidelines on the management of AL amyloidosis

Oct 2014

The purpose of this guideline is to provide guidance on the management of patients with AL..

... amyloidosis.

Online CME

Biological treatment for inflammatory arthritis

After completing this module, you should be able to: know what biological treatments are, be able to explain to patients how they work, know what conditions they are used for,...

Myasthenia gravis: a guide to diagnosis and treatment

After completing this module you should be able to: make a clinical diagnosis of myasthenia gravis, select appropriate diagnostic tests to confirm your diagnosis, and understand the principles of therapy...

Clinical Trials

GHSG-AFM13 An Open-label, Multicenter Phase II Trial With AFM13 in Patients With Relapsed or Refractory Hodgkin Lymphoma

Wed 17 Dec 2014

The study is designed: - to demonstrate efficacy of AFM13 with an optimized treatment schedule - to decide whether AFM13 warrants further investigation in a phase III clinical ...

Azacytidine (Vidaza®) Versus Fludarabine and Cytarabine (Fluga Scheme) in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (FLUGAZA)

Wed 10 Dec 2014

The hypothesis is that the replacement of the standard fludarabine and cytarabine based therapy by azacytidine could result in an improvement of RFS and OS rates in the experimental arm. To fulfill ...

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