Stephanie J. Dancer BSc, MB BS, MSc, MD, FRCPath, DTM&H, Consultant Microbiologist, NHS Lanarkshire, Scotland
A 72-year-old man was referred by his general practitioner complaining of intermittent pain in the legs on exercise.
Suma Kumar, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
A 68-year-old man presented with a four-week history of left-sided, dull, aching chest pain. He had known ischaemic heart disease, previous coronary artery bypass grafting, chronic obstructive pulmonary disease and treated duodenal ulceration.
Would you trust a doctor to decide if you are an appropriate subject for assisted dying? I wouldn't, neither should you, and my colleagues who are not fortunate enough to be retired will be crazy if they allow themselves to be dragged into the process. Proponents of legislative change should man up and face the implications of their proposals, without hiding behind the medical profession.
Background: A multicenter study in the late 1990s demonstrated suboptimal emergency asthma care for pregnant women in US emergency departments (EDs). After a decade, follow-up data are lacking. ...
Background: The intensity and frequency of sounds in a lung sound analysis (LSA) may be related to airway constriction; however, whether any factors of an LSA can predict airway eosinophilic ...
Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upJun 2014
The ESMO Clinical Practice Guidelines (CPG) are intended to provide the user with a set of..
The purpose of this guideline is to provide guidance on the management of pregnant women with red..
After completing this module you should know the common causes of mucocutaneous lesions in patients with HIV infection. You should know how to recognise such lesions and, where appropriate, how...
This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the management of allergic rhinoconjunctivitis and other...
This module should help you to: identify different types of acne, explain the condition to patients, choose the best treatment, know when to refer patients to a specialist and coordinate...
Study of Crenolanib in Combination Combination With Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia and Activating FLT3 Mutations19-11-2014
The main trial is a double-blinded, placebo-controlled, randomized, phase III, multi-center trial in adult patients with relapsed or refractory AML harboring an activating FLT3 mutation as defined in the inclusion /exclusion criteria.
An initial safety run-in phase of the study will be performed in an..
The double-blinded, placebo-controlled randomized portion will start after the completion of the safety run-in phase and positive opinion of the Trial Committee.
Crenolanib starts on day 7 of MC and is given continuously thereafter, except for days of chemotherapy; if receiving allogeneic HSCT, crenolanib is held during conditioning and transplant and restarts no sooner than 30 days after transplant.
Sample size randomized phase: 276 patients
Primary objective: To evaluate the impact of crenolanib given in combination with salvage chemotherapy and consolidation including allogeneic hematopoietic stem cell transplantation and ongoing single agent maintenance therapy with crenolanib on event-free (EFS) and overall survival (OS) in adult patients with relapsed or refractory AML harboring FLT3 activating mutations.
Response Rate and Duration After Discontinuation Thrombopoietin Receptor Agonists Primary Immune Thrombocytopenia17-11-2014
The primary objective of the study is the evaluation of sustained response rate after discontinuation of treatment with TPO-RAs, Eltrombopag and Romiplostim, in persistent or chronic pITP patients who failed one or more therapy lines, splenectomy included.