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Clinical Case Studies

HIV Seroconversion

Infection: HIV Infection

Antonia Ho, Specialist Registrar in Infectious Diseases, Gartnavel General Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK

Case History
A 29-year-old man was admitted with a week's history of general malaise accompanied by severe myalgia, abdominal pain, diarrhoea, headache, dry cough and swelling and redness of his eyes. He was a heavy drinker, and had fallen into the river Clyde two weeks previously while inebriated.

Hypersensitivity Pneumonitis

Respiratory Medicine & Allergy: Non granuloma interstitial lung disease

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK
Boris Lams, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 49-year-old Cypriot woman was referred with a nine-month history of gradually increasing breathlessness and a dry cough. She was breathless at 100 yards.

Medical Videos

An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells
An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System

Recent Drug Updates

Medical Images

Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer (NSCLC)
Osteoporosis
Osteoporosis
Amiodarone Pulmonary Toxicity
Amiodarone Pulmonary Toxicity
Tuberculous granuloma
Tuberculous granuloma
Miliary TB
Miliary TB
Extrapulmonary TB
Extrapulmonary TB
Diffuse Alveolar Haemorrhage
Diffuse Alveolar Haemorrhage
Renal stone shown in CT scan
Renal stone shown in CT scan
Pneumocystis
Pneumocystis
Hematoxylin and eosin stain
Hematoxylin and eosin stain

Clinical Guidelines

Osteoarthritis: Care and management in adults

Feb 2014

The current update addresses issues around decision-making and referral thresholds for surgery, and..

... includes new recommendations about diagnosis and follow-up. The update also contains recommendations based on new evidence about the use of nutraceuticals, hyaluronans and acupuncture in the management of osteoarthritis.

Guidelines for the diagnosis and management of Multiple Myeloma 2014

Feb 2014

The objective of this guideline is to provide healthcare professionals with clear guidance on the..

... diagnosis and management of patients with multiple myeloma

Online CME

HIV infection: diagnostic picture tests

Apr 2013
... mucocutaneous lesions in patients with HIV infection. You should know how to recognise such lesions and, where appropriate, how to start treatment.

Evaluating and Addressing the Consequences of Transplant Immunosuppression

Nov 2013
... and services to SOT (solid organ transplant) recipients by providing expert perspective on the latest evidence for determining best immunosuppression strategies to prevent allograft rejection and long-term health risks in SOT recipients, on how and when to initiate calcineurin inhibitor minimization strategies, and on how to make individualized, evidence-based decisions about maintenance immunosuppression in patients with SOT.

Clinical Trials

Carfilzomib In Combination With Bendamustine And Dexamethasone In Refractory Or Relapsed Multiple Myeloma

05-02-2014

Open-label phase Ib/II, multicenter, international non-comparative trial. This study is designed to determine the safety and efficacy of the novel salvage regimen (CBd) followed by a carfilzomib maintenance in patients with relapsed or refractory multiple myeloma. Patients will be evaluated at scheduled visits in up..

... to 4 study periods: pretreatment, treatment, maintenance and long-term follow-up (LTFU).

Treatment of Chronic Pain From Osteoarthritis

08-01-2014

Osteoarthritis is a common joint disorder in the elder population.The current treatment options include both a non-pharmacological approach (physiokinesitherapy, diet) or if this fails, a pharmacological approach that relies in the first instance on drugs such as paracetamol, non-steroidal anti-inflammatory (including..

... inhibitors of cyclo-oxygenase). However, the use of these drugs is limited, by the roof effect concerning analgesia, and by the potential side effects. When pharmacological treatments with non-opioid medications fail, and a moderate-to-severe pain reduces the quality of life of the patient, international guidelines suggest the use of opioid drugs.
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