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Symptomatic Asthma

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Clinical Case Studies

Vascular Graft Infection

Infection: Cardiovascular Infections

Stephanie J. Dancer BSc, MB BS, MSc, MD, FRCPath, DTM&H, Consultant Microbiologist, NHS Lanarkshire, Scotland

Case History
A 72-year-old man was referred by his general practitioner complaining of intermittent pain in the legs on exercise.

Non-Small Cell Lung Cancer (NSCLC)

Respiratory Medicine & Allergy: Lung Cancer

Suma Kumar, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 68-year-old man presented with a four-week history of left-sided, dull, aching chest pain. He had known ischaemic heart disease, previous coronary artery bypass grafting, chronic obstructive pulmonary disease and treated duodenal ulceration.

Blog

Would you trust a doctor to decide if you are an appropriate subject for assisted dying? I wouldn't, neither should you, and my colleagues who are not fortunate enough to be retired will be crazy if they allow themselves to be dragged into the process. Proponents of legislative change should man up and face the implications of their proposals, without hiding behind the medical profession.

Medical Videos

An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells
An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System

Recent Drug Updates

Medical Journal Abstracts on Immunology

Improved Management of Acute Asthma among Pregnant Women Presenting to the Emergency Department

Thu 30 Oct 2014 -  CHEST Journal

Background: A multicenter study in the late 1990s demonstrated suboptimal emergency asthma care for pregnant women in US emergency departments (EDs). After a decade, follow-up data are lacking. ...

Prediction of Airway Inflammation in Patients with Asymptomatic Asthma by Using Lung Sound Analysis

Sat 04 Oct 2014 -  The Journal of Allergy and Clinical Immunology: In Practice

Background: The intensity and frequency of sounds in a lung sound analysis (LSA) may be related to airway constriction; however, whether any factors of an LSA can predict airway eosinophilic ...

Medical Images

Tuberculosis
Tuberculosis
HIV infected adults (15 years and above) who are female in %
HIV infected adults (15 years and above) who are female in %
Suspected jaundice
Suspected jaundice
MRI of male who presented with right arm partialcomplex seizures
MRI of male who presented with right arm partialcomplex seizures
Ring-enhancing lesion (arrow) in the middle of moderate peri-lesional cerebral oedema
Ring-enhancing lesion (arrow) in the middle of moderate peri-lesional cerebral oedema
Idiopathic Interstitial Pneumonias
Idiopathic Interstitial Pneumonias
Key events leading up to the era of HAART
Key events leading up to the era of HAART
PML from a brain biopsy specimen
PML from a brain biopsy specimen
Pnemothorax in right lung
Pnemothorax in right lung
Distribution of VZV
Distribution of VZV

Clinical Guidelines

Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Jun 2014

The ESMO Clinical Practice Guidelines (CPG) are intended to provide the user with a set of..

... recommendations for the best standards of cancer care, based on the findings of evidence-based medicine. Each Clinical Practice Guideline includes information about: the incidence of the malignancy, diagnostic criteria, staging of disease and risk assessment, treatment plans, response evaluation and follow-up.

The Management of Women with Red Cell Antibodies during Pregnancy

May 2014

The purpose of this guideline is to provide guidance on the management of pregnant women with red..

... cell antibodies predating the pregnancy or those developing antibodies during pregnancy. The guideline also includes the management of fetal anaemia caused by red cell antibodies, as well as the early management of the neonate at risk of anaemia and/or hyperbilirubinaemia. It does not address the management of the pregnant woman with anti-platelet antibodies or other autoimmune or alloimmune antibodies.

Online CME

HIV infection: diagnostic picture tests

After completing this module you should know the common causes of mucocutaneous lesions in patients with HIV infection. You should know how to recognise such lesions and, where appropriate, how...

Implementing Best Practices in the Management of Allergic Diseases

This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the management of allergic rhinoconjunctivitis and other...

Acne: managing patients in primary care

This module should help you to: identify different types of acne, explain the condition to patients, choose the best treatment, know when to refer patients to a specialist and coordinate...

Clinical Trials

Study of Crenolanib in Combination Combination With Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia and Activating FLT3 Mutations

19-11-2014

The main trial is a double-blinded, placebo-controlled, randomized, phase III, multi-center trial in adult patients with relapsed or refractory AML harboring an activating FLT3 mutation as defined in the inclusion /exclusion criteria.

An initial safety run-in phase of the study will be performed in an..

... open- label administering the study drug crenolanib with salvage chemotherapy consisting of mitoxantrone and cytarabine (MC) in 12 patients according to the experimental arm of the study. After completion of this safety run-in phase, toxicity and response data will be provided to the external Data and Safety Monitoring Board (DSMB) and the Trial- Committee by the Coordinating Investigator. The Trial Committee will decide on the basis of these data and the recommendation of the DSMB on dose- modification and the further conduct of the study with regard to the double-blinded, placebo-controlled, randomized phase of the study.

The double-blinded, placebo-controlled randomized portion will start after the completion of the safety run-in phase and positive opinion of the Trial Committee.

Crenolanib starts on day 7 of MC and is given continuously thereafter, except for days of chemotherapy; if receiving allogeneic HSCT, crenolanib is held during conditioning and transplant and restarts no sooner than 30 days after transplant.

Sample size randomized phase: 276 patients

Primary objective: To evaluate the impact of crenolanib given in combination with salvage chemotherapy and consolidation including allogeneic hematopoietic stem cell transplantation and ongoing single agent maintenance therapy with crenolanib on event-free (EFS) and overall survival (OS) in adult patients with relapsed or refractory AML harboring FLT3 activating mutations.

Response Rate and Duration After Discontinuation Thrombopoietin Receptor Agonists Primary Immune Thrombocytopenia

17-11-2014

The primary objective of the study is the evaluation of sustained response rate after discontinuation of treatment with TPO-RAs, Eltrombopag and Romiplostim, in persistent or chronic pITP patients who failed one or more therapy lines, splenectomy included.

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