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Rheumatology Trends

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Rheumatoid Arthritis (RA) is a chronic, systemic inflammatory autoimmune disease that affects up to 1% of the adult population across the developing world, including more than 1 million people in the US alone. As a result, RA represents the world’s biggest market for drug treatments, aside from oncology. Currently this market is dominated by two categories of treatment: non-steroidal anti-inflammatory drugs (NSAIDs), and biologic disease-modifying anti-rheumatic drugs (DMARDs). The gold standard of treatment has been an older oral DMARD methotrexate (MTX) which is included in most combination therapies but it is beset by unwelcome side-effects. Now the leading DMARDs target tumour necrosis factor (TNF), a key inflammatory mediator. These have had a major impact on outcomes, due to improved tolerability and efficacy

Clinical Case Studies

Aspiration Syndrome

Respiratory Medicine & Allergy: Obstructive Lung Disease/Small Airways Disease

Boris Lams, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 45-year-old woman presented with a severe persistent cough that had not resolved with antibiotics or steroids. There was no sputum production, wheeze or haemoptysis.

Mediastinal Mass: Bronchogenic Cyst

Respiratory Medicine & Allergy: Lung Cancer

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK

Case History
A 24-year-old woman was seen in the chest clinic with an eight-week history of cough with occasional sputum, fever and malaise. She also described an occasional nagging pain under her sternum and palpitations.

Latest News

Medical Videos

An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System
An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells

Recent Drug Updates

Medical Journal Abstracts on Immunology

Which one is more effective, filgrastim or lenograstim, during febrile neutropenia attack in hospitalized patients with solid tumors?

Tue 14 Apr 2015 -  Which one is more effective, filgrastim or lenograstim, during febrile neutropenia attack in hospitalized patients with solid tumors?

BACKGROUND: Chemotherapy-induced febrile neutropenia (FN) with solid tumors causes mortality and morbidity at a significant rate. The purpose of this study was to compare the effects of filgastrim ...

Role of lipegfilgrastim in the management of chemotherapy-induced neutropenia.

Wed 01 Apr 2015 -  Role of lipegfilgrastim in the management of chemotherapy-induced neutropenia.

Chemotherapy, irradiation, and other agents are widely used to target the process of cell division in neoplastic cells. However, while these therapies are effective against most cancers, the high ...

Medical Images

T1-weighted transverse cranial MRI
T1-weighted transverse cranial MRI
Hypersensitivity rash
Hypersensitivity rash
Acute retroviral syndrome
Acute retroviral syndrome
Lipodystrophy
Lipodystrophy
Allergic Bronchopulmonary Aspergillosis
Allergic Bronchopulmonary Aspergillosis
T1 transverse MR image from a white male who presented with increasing confusion
T1  transverse MR image from a white male who presented with increasing confusion
PCP pneumocystis pneumonia
PCP pneumocystis pneumonia
Cryptogenic Organizing Pneumonia
Cryptogenic Organizing Pneumonia
Gentamicin concentration time profile
Gentamicin concentration time profile
Pulmonary angiogram
Pulmonary angiogram

Clinical Guidelines

Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care

Feb 2015

Key aspects of this guideline include establishing a diagnosis; referral into secondary care only..

... after identification of 'red flags' (symptoms and/or features that may be caused by another condition that needs investigation); providing lifestyle advice; drug and psychological interventions; and referral and follow-up.

Guidelines on the management of AL amyloidosis

Oct 2014

The purpose of this guideline is to provide guidance on the management of patients with AL..

... amyloidosis.

Online CME

Biological treatment for inflammatory arthritis

After completing this module, you should be able to: know what biological treatments are, be able to explain to patients how they work, know what conditions they are used for,...

Myasthenia gravis: a guide to diagnosis and treatment

After completing this module you should be able to: make a clinical diagnosis of myasthenia gravis, select appropriate diagnostic tests to confirm your diagnosis, and understand the principles of therapy...

Clinical Trials

GHSG-AFM13 An Open-label, Multicenter Phase II Trial With AFM13 in Patients With Relapsed or Refractory Hodgkin Lymphoma

Wed 17 Dec 2014

The study is designed: - to demonstrate efficacy of AFM13 with an optimized treatment schedule - to decide whether AFM13 warrants further investigation in a phase III clinical ...

Azacytidine (Vidaza®) Versus Fludarabine and Cytarabine (Fluga Scheme) in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (FLUGAZA)

Wed 10 Dec 2014

The hypothesis is that the replacement of the standard fludarabine and cytarabine based therapy by azacytidine could result in an improvement of RFS and OS rates in the experimental arm. To fulfill ...

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