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Clinical Case Studies

Pandemic Influenza A (H1N1) 2009

Infection: Infections in Critical Care

Kevin Rooney, Consultant in Intensive Care Medicine and Professor of Care Improvement, School of Health, Nursing and Midwifery, University of the West of Scotland, Paisley, UK

Case History
A 32-year-old asthmatic, pregnant female at 24 weeks gestation presented to the antenatal clinic with a four-day history of fever, malaise, productive cough and worsening shortness of breath. On examination she was short of breath at rest, with a respiratory rate of 36 breaths/min, and was unable to speak in sentences.

Small Cell Lung Cancer (SCLC)

Respiratory Medicine & Allergy: Lung Cancer

Oni Choudhury, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 62-year-old woman presented with a 2-3-month history of breathlessness, non-productive cough, weight loss, lethargy and ankle oedema. Her exercise tolerance was limited to 50 yards by breathlessness.

Medical Videos

An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System
An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells

Recent Drug Updates

Medical Images

Characteristic waxy, dome-shaped, umbilicated flesh-coloured papules caused by the DNA pox virus
Characteristic waxy, dome-shaped, umbilicated flesh-coloured papules caused by the DNA pox virus
Mesothelioma and Asbestos-related Pleural Disease
Mesothelioma and Asbestos-related Pleural Disease
Abdominal X-ray
Abdominal X-ray
Nevirapine hypersensitivity
Nevirapine hypersensitivity
Suspected jaundice
Suspected jaundice
Oesophageal candidiasis.
Oesophageal candidiasis.
Pneumocystis jirovecii Pneumonia
Pneumocystis jirovecii Pneumonia
Metavir stage 3 (F3)
Metavir stage 3 (F3)
Serial chest X-rays
Serial chest X-rays
Longitudinal melanonychia
Longitudinal melanonychia

Clinical Guidelines

Osteoarthritis: Care and management in adults

Feb 2014

The current update addresses issues around decision-making and referral thresholds for surgery, and..

... includes new recommendations about diagnosis and follow-up. The update also contains recommendations based on new evidence about the use of nutraceuticals, hyaluronans and acupuncture in the management of osteoarthritis.

Guidelines for the diagnosis and management of Multiple Myeloma 2014

Feb 2014

The objective of this guideline is to provide healthcare professionals with clear guidance on the..

... diagnosis and management of patients with multiple myeloma

Online CME

HIV infection: diagnostic picture tests

After completing this module you should know the common causes of mucocutaneous lesions in patients with HIV infection. You should know how to recognise such lesions and, where appropriate, how...

Implementing Best Practices in the Management of Allergic Diseases

This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the management of allergic rhinoconjunctivitis and other...

In-Depth Discussion of Key Data on Immunotherapy for Allergic Diseases

This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the risks and benefits of allergen immunotherapy...

Clinical Trials

Digitized Grip Strength

21-07-2014

Rheumatoid arthritis (RA) is the most common chronic inflammatory arthritis in adults. Monitoring of disease activity is based on Disease Activity Score 28 (DAS 28). There are also validated questionnaires for self-assessment of the disease by the patient. Grip strength measured using a digitized sensor used by the..

... patient could be an additional tool to the remote monitoring of patients with RA.

Main Objective : To evaluate the correlation between the measurement of grip strength in the dominant hand measured by a digital sensor and activity of RA assessed by DAS 28

Secondary objective : Evaluate the correlation between grip strength of the dominant hand and :

- scores of fatigue and pain (VAS and FACIT)
- the self-assessment scores known in RA : functional index Health Assessment Questionnaire (HAQ) and scores of activity RAPID3 and RADAI5.

It is a cross-sectional study involving 150 patients followed in our department for RA. Grip strength of the dominant hand will be measured by a digitalized sensor during a single visit integrating into the routine monitoring of patients.

A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Subjects and Patients With Plaque Psoriasis

17-07-2014

This study is a phase I, randomised, double blind (sponsor unblinded), placebo-controlled, single ascending dose study GSK2831781 administered by IV. GSK2831781 is a humanized Antibody Dependent Cell Cytotoxicity (ADCC) enhanced monoclonal afucosylated antibody that is specific to the Lymphocyte Activation Gene-3..

... (LAG-3) protein. This is the first administration of GSK2831781 in humans and will evaluate in two parts the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of single IV doses of GSK2831781 administered to healthy subjects previously vaccinated with Bacillus Calmette Guérin (BCG) (Part A delayed type hypersensitivity [DTH] cohorts) and patients with plaque psoriasis (Part B). The inclusion of DTH and psoriasis subjects to explore the mechanism in biopsies and clinical response endpoints in these populations, as well as investigate systemic biomarkers will provide useful information prior to conducting studies in other immune-inflammatory disease which will involve more invasive tissue biopsies. Measuring the pharmacology of GSK2831781 using the depletion of LAG-3+ T-cells in skin biopsies from Tuberculin Purified Protein Derivative (PPD) skin challenge and lesional skin biopsies from patients with psoriasis, will be helpful in understanding of the dose response relationship, which will be important for designing future studies in immuno-inflammatory diseases, including psoriasis. Approximately 63 subjects will be enrolled to complete dosing and critical assessments. The subject numbers will be split to approximately 31 healthy subjects (Part A) and 32 patients with psoriasis (Part B).

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