Immunology Topic Homepage

CSU Knowledge Centre

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The Chronic Spontaneous Urticaria (CSU) Knowledge Centre has been developed to address the current lack of early diagnosis of this condition. Urticaria is more common than previously thought and studies suggest chronic urticaria affects up to 1% of the population at any given time with CSU responsible for two-thirds of these cases.

Allergists, immunologists, dermatologists and other healthcare professionals involved in the management of CSU will find a range of content to support you in effectively diagnosing and treating the condition.

In this resource, you will find a disease overview, symposia highlights platform, video channel and additional resources including an events calendar and useful external links.

Psoriasis Knowledge Centre

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Psoriasis is a chronic inflammatory disease affecting approximately 2% of the world’s population. The Psoriasis Knowledge Centre provides dermatologists, family medicine doctors and other healthcare professionals with relevant information including epidemiology, pathophysiology, diagnosis and more.

A treatment section reviews the established treatments available for psoriasis and considers their modes of action, available clinical data and place in the therapeutic pathway.

Rheumatology Trends

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Rheumatoid Arthritis (RA) is a chronic, systemic inflammatory autoimmune disease that affects up to 1% of the adult population across the developing world, including more than 1 million people in the US alone. As a result, RA represents the world’s biggest market for drug treatments, aside from oncology. Currently this market is dominated by two categories of treatment: non-steroidal anti-inflammatory drugs (NSAIDs), and biologic disease-modifying anti-rheumatic drugs (DMARDs). The gold standard of treatment has been an older oral DMARD methotrexate (MTX) which is included in most combination therapies but it is beset by unwelcome side-effects. Now the leading DMARDs target tumour necrosis factor (TNF), a key inflammatory mediator. These have had a major impact on outcomes, due to improved tolerability and efficacy

Clinical Case Studies

Sickle Cell Lung Disease

Respiratory Medicine & Allergy: Pulmonary Vascular Diseases

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK
Boris Lams, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
Christopher Kosky, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 40-year-old man with known homozygous (HbSS) sickle cell disease (SCD) presented to the emergency department with a three-day history of cough, fever and sweats. He denied any chest pain.

Mediastinal Mass: Bronchogenic Cyst

Respiratory Medicine & Allergy: Lung Cancer

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK

Case History
A 24-year-old woman was seen in the chest clinic with an eight-week history of cough with occasional sputum, fever and malaise. She also described an occasional nagging pain under her sternum and palpitations.

Latest News

Medical Videos

An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells
An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System

Recent Drug Updates

Medical Journal Abstracts on Immunology

Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

Fri 01 May 2015 -  Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

We have previously reported on the efficacy and tolerability of hyper-CVAD regimen (cyclophosphamide, vincristine, Adriamycin, and dexamethasone) and imatinib followed by imatinib-based ...

Which one is more effective, filgrastim or lenograstim, during febrile neutropenia attack in hospitalized patients with solid tumors?

Tue 14 Apr 2015 -  Which one is more effective, filgrastim or lenograstim, during febrile neutropenia attack in hospitalized patients with solid tumors?

BACKGROUND: Chemotherapy-induced febrile neutropenia (FN) with solid tumors causes mortality and morbidity at a significant rate. The purpose of this study was to compare the effects of filgastrim ...

Medical Images

Wegener's Granulomatosis and Small Vessel Pulmonary Vasculitides
Wegener's Granulomatosis and Small Vessel Pulmonary Vasculitides
Metavir stage 2 (F2)
Metavir stage 2 (F2)
Hypersensitivity rash
Hypersensitivity rash
Immunocytochemical staining
Immunocytochemical staining
HIV-1 group M subtypes and CRFs
HIV-1 group M subtypes and CRFs
RNA: ribonucleic acid
RNA: ribonucleic acid
Key events leading up to the era of HAART
Key events leading up to the era of HAART
HIV envelope glycoprotein
HIV envelope glycoprotein
Hematoxylin and eosin stain
Hematoxylin and eosin stain
Pneumocystis jirovecii Pneumonia
Pneumocystis jirovecii Pneumonia

Clinical Guidelines

Irritable bowel syndrome in adults: diagnosis and management of irritable bowel syndrome in primary care

Feb 2015

Key aspects of this guideline include establishing a diagnosis; referral into secondary care only..

... after identification of 'red flags' (symptoms and/or features that may be caused by another condition that needs investigation); providing lifestyle advice; drug and psychological interventions; and referral and follow-up.

Guidelines on the management of AL amyloidosis

Oct 2014

The purpose of this guideline is to provide guidance on the management of patients with AL..

... amyloidosis.

Online CME

Biological treatment for inflammatory arthritis

After completing this module, you should be able to: know what biological treatments are, be able to explain to patients how they work, know what conditions they are used for,...

Myasthenia gravis: a guide to diagnosis and treatment

After completing this module you should be able to: make a clinical diagnosis of myasthenia gravis, select appropriate diagnostic tests to confirm your diagnosis, and understand the principles of therapy...

Clinical Trials

GHSG-AFM13 An Open-label, Multicenter Phase II Trial With AFM13 in Patients With Relapsed or Refractory Hodgkin Lymphoma

Wed 17 Dec 2014

The study is designed: - to demonstrate efficacy of AFM13 with an optimized treatment schedule - to decide whether AFM13 warrants further investigation in a phase III clinical ...

Azacytidine (Vidaza®) Versus Fludarabine and Cytarabine (Fluga Scheme) in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (FLUGAZA)

Wed 10 Dec 2014

The hypothesis is that the replacement of the standard fludarabine and cytarabine based therapy by azacytidine could result in an improvement of RFS and OS rates in the experimental arm. To fulfill ...

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