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Clinical Case Studies

Mesothelioma and Asbestos-related Pleural Disease

Respiratory Medicine & Allergy: Pleural Disease

Amina Aitsi-Selmi, Guy's and St Thomas' NHS Foundation Trust, London, UK
Charles Twort, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 64-year-old carpenter was referred to the chest clinic with a four-week history of increasing breathlessness on exercise, persistent dry cough, weight loss and night sweats. He complained of persistent, right-sided chest ache but denied any wheeze or haemoptysis.

Parapneumonic Effusion

Respiratory Medicine & Allergy: Pleural Disease

Liju Ahmed, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 38-year-old female clerical worker presented to the emergency department with a five-day history of fever, cough productive of green sputum, progressive breathlessness and gradual-onset pleuritic chest pain. She had no relevant past medical history or previous regular medication.

Medical Videos

An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells
An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System

Recent Drug Updates

Medical Images

Scarring of lymph nodes
Scarring of lymph nodes
Hospital-acquired Pneumonia (HAP)
Hospital-acquired Pneumonia (HAP)
PML from a brain biopsy specimen
PML from a brain biopsy specimen
Cerebral tuberculoma with a paradoxical reaction in HIV
Cerebral tuberculoma with a paradoxical reaction in HIV
HRCT scan - Wegener's Granulomatosis and the Small Vessel Pulmonary Vasculitides
HRCT scan - Wegener's Granulomatosis and the Small Vessel Pulmonary Vasculitides
Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer (NSCLC)
Metavir stage 1 (F1)
Metavir stage 1 (F1)
Tuberculous granuloma
Tuberculous granuloma
Hematoxylin and eosin stain
Hematoxylin and eosin stain
Hypersensitivity rash
Hypersensitivity rash

Clinical Guidelines

Osteoarthritis: Care and management in adults

Feb 2014

The current update addresses issues around decision-making and referral thresholds for surgery, and..

... includes new recommendations about diagnosis and follow-up. The update also contains recommendations based on new evidence about the use of nutraceuticals, hyaluronans and acupuncture in the management of osteoarthritis.

Guidelines for the diagnosis and management of Multiple Myeloma 2014

Feb 2014

The objective of this guideline is to provide healthcare professionals with clear guidance on the..

... diagnosis and management of patients with multiple myeloma

Online CME

HIV infection: diagnostic picture tests

Apr 2013
... mucocutaneous lesions in patients with HIV infection. You should know how to recognise such lesions and, where appropriate, how to start treatment.

Evaluating and Addressing the Consequences of Transplant Immunosuppression

Nov 2013
... and services to SOT (solid organ transplant) recipients by providing expert perspective on the latest evidence for determining best immunosuppression strategies to prevent allograft rejection and long-term health risks in SOT recipients, on how and when to initiate calcineurin inhibitor minimization strategies, and on how to make individualized, evidence-based decisions about maintenance immunosuppression in patients with SOT.

Clinical Trials

Carfilzomib In Combination With Bendamustine And Dexamethasone In Refractory Or Relapsed Multiple Myeloma

05-02-2014

Open-label phase Ib/II, multicenter, international non-comparative trial. This study is designed to determine the safety and efficacy of the novel salvage regimen (CBd) followed by a carfilzomib maintenance in patients with relapsed or refractory multiple myeloma. Patients will be evaluated at scheduled visits in up..

... to 4 study periods: pretreatment, treatment, maintenance and long-term follow-up (LTFU).

Treatment of Chronic Pain From Osteoarthritis

08-01-2014

Osteoarthritis is a common joint disorder in the elder population.The current treatment options include both a non-pharmacological approach (physiokinesitherapy, diet) or if this fails, a pharmacological approach that relies in the first instance on drugs such as paracetamol, non-steroidal anti-inflammatory (including..

... inhibitors of cyclo-oxygenase). However, the use of these drugs is limited, by the roof effect concerning analgesia, and by the potential side effects. When pharmacological treatments with non-opioid medications fail, and a moderate-to-severe pain reduces the quality of life of the patient, international guidelines suggest the use of opioid drugs.
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