Immunology Topic Homepage

All Knowledge Centres

Men's Health

Visit this Knowledge Centre

Anti-Infectives Knowledge Network

Visit Knowledge Network

Bedwetting Knowledge Centre

Visit this Knowledge Centre

Hepatitis

Visit this Knowledge Centre

Neuropathic Pain

Visit this Knowledge Centre

Cystic Fibrosis

Visit this Knowledge Centre

Insomnia

Visit this Knowledge Centre

Niemann-Pick type C

Visit this Knowledge Centre

Soft Tissue Sarcoma

Visit this Knowledge Centre

Heart Failure

Visit this Knowledge Centre

Type 2 Diabetes Knowledge Centre

Visit this Knowledge Centre

Clinical Case Studies

Lemierre's Disease, Boris Lams

Respiratory Medicine & Allergy: Infection

Christopher Kosky, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 22-year-old Caucasian male presented to the emergency department complaining of neck and left-sided chest pain. He was well until five days previously when he developed a sore throat.

Painful Spreading Cellulitis in an Injecting Drug User

Infection: Infections in Drug Users

Nicholas Kennedy, Consultant in Infectious Diseases and General Medicine, Monklands General Hospital, NHS Lanarkshire, Airdrie, UK

Case History
A 26-year-old man with a history of injecting drug use was admitted to hospital with a two-day history of pain and swelling of his left leg. He had no forearm veins left so he now injected into his femoral veins.

Medical Videos

An Animation Demonstrating the Role of Natural Killer Cells
An Animation Demonstrating the Role of Natural Killer Cells
An Animation of The Main Roles of the Immune System
An Animation of The Main Roles of the Immune System

Recent Drug Updates

Medical Images

HIV infected adults (15 years and above) who are female in %
HIV infected adults (15 years and above) who are female in %
Diffuse hyperintensity signal
Diffuse hyperintensity signal
Cerebral atrophy
Cerebral atrophy
Sarcoma on gum
Sarcoma on gum
Pulmonary nodule
Pulmonary nodule
Characteristic waxy, dome-shaped, umbilicated flesh-coloured papules caused by the DNA pox virus
Characteristic waxy, dome-shaped, umbilicated flesh-coloured papules caused by the DNA pox virus
Metavir stage 1 (F1)
Metavir stage 1 (F1)
Immunocytochemical staining
Immunocytochemical staining
MRI of male who presented with right arm partialcomplex seizures
MRI of male who presented with right arm partialcomplex seizures
Wegener's Granulomatosis and Small Vessel Pulmonary Vasculitides
Wegener's Granulomatosis and Small Vessel Pulmonary Vasculitides

Clinical Guidelines

Osteoarthritis: Care and management in adults

Feb 2014

The current update addresses issues around decision-making and referral thresholds for surgery, and..

... includes new recommendations about diagnosis and follow-up. The update also contains recommendations based on new evidence about the use of nutraceuticals, hyaluronans and acupuncture in the management of osteoarthritis.

Guidelines for the diagnosis and management of Multiple Myeloma 2014

Feb 2014

The objective of this guideline is to provide healthcare professionals with clear guidance on the..

... diagnosis and management of patients with multiple myeloma

Online CME

HIV infection: diagnostic picture tests

After completing this module you should know the common causes of mucocutaneous lesions in patients with HIV infection. You should know how to recognise such lesions and, where appropriate, how...

Implementing Best Practices in the Management of Allergic Diseases

This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the management of allergic rhinoconjunctivitis and other...

In-Depth Discussion of Key Data on Immunotherapy for Allergic Diseases

This activity is intended for allergists and other physicians with an interest in allergic diseases. The goal of this activity is to discuss the risks and benefits of allergen immunotherapy...

Clinical Trials

A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Subjects and Patients With Plaque Psoriasis

17-07-2014

This study is a phase I, randomised, double blind (sponsor unblinded), placebo-controlled, single ascending dose study GSK2831781 administered by IV. GSK2831781 is a humanized Antibody Dependent Cell Cytotoxicity (ADCC) enhanced monoclonal afucosylated antibody that is specific to the Lymphocyte Activation Gene-3..

... (LAG-3) protein. This is the first administration of GSK2831781 in humans and will evaluate in two parts the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of single IV doses of GSK2831781 administered to healthy subjects previously vaccinated with Bacillus Calmette Guérin (BCG) (Part A delayed type hypersensitivity [DTH] cohorts) and patients with plaque psoriasis (Part B). The inclusion of DTH and psoriasis subjects to explore the mechanism in biopsies and clinical response endpoints in these populations, as well as investigate systemic biomarkers will provide useful information prior to conducting studies in other immune-inflammatory disease which will involve more invasive tissue biopsies. Measuring the pharmacology of GSK2831781 using the depletion of LAG-3+ T-cells in skin biopsies from Tuberculin Purified Protein Derivative (PPD) skin challenge and lesional skin biopsies from patients with psoriasis, will be helpful in understanding of the dose response relationship, which will be important for designing future studies in immuno-inflammatory diseases, including psoriasis. Approximately 63 subjects will be enrolled to complete dosing and critical assessments. The subject numbers will be split to approximately 31 healthy subjects (Part A) and 32 patients with psoriasis (Part B).

Prospective Evaluation of a Scoring System in Patients Newly Diagnosed With Crohn's Disease (PROGNOS)

16-07-2014

The purpose of this study is to prospectively evaluate a scoring system to predict a mild course of disease in patients newly diagnosed with Crohn's disease.

Back to top