Cystic fibrosis (CF) is a genetic condition caused by a defect in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. In people with CF, the protein does not work effectively, resulting in thick, sticky secretions at epithelial membranes – the underlying defect in CF.1 Cystic fibrosis can have multi-organ involvement with a range of complications and comorbidities reported.
The aim of the Cystic Fibrosis Knowledge Centre is to provide healthcare professionals with accurate clinical information including disease awareness information, emerging and established treatment options and current best practice based on recently updated guidelines by the European Cystic Fibrosis Society (ECFS). A resources section contains external links to upcoming medical conferences and patient support groups.
This resource is developed by EPG Health Media for epgonline.org, supported by an independent educational grant from Vertex.
References: 1. Boucher RC. Cystic Fibrosis. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL et al., editors. Harrison's Internal Medicine. 16th ed. New York: McGraw-Hill; 2005. p. 1-9.