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Latest Drugs
Cardiology Drug Data - A-Z (English)
Drug Class Description
ACE inhibitors / thiazide diuretics (thiazides).Generic Name
Lisinopril, hydrochlorothiazideDrug Description
Zestoretic 20: white tablets. Zestoretic 10: peach tablets.Presentation
Zestoretic 20: Lisinopril (as dihydrate) 20mg, hydrochlorothiazide 12.5mg. Zestoretic 10: Lisinopril (as dihydrate) 10mg, hydrochlorothiazide 12.5mg.Indications
Mild to moderate hypertension in patients stabilised on the individual components given in the same proportions.
Adult Dosage
1 daily. Maximum 2 daily.Child Dosage
Not recommended.Contra Indications
Anuria, angioneurotic oedema related to previous ACE inhibitor therapy, pregnancy, lactation.Special Precautions
Fluid or electrolyte imbalance, ischaemic heart or cerebrovascular disease, haemodialysis, renal or hepatic impairment, gout/hyperuricaemia, diabetes, surgery/anaesthesia.Interactions
K+-supplements, K+-sparing diuretics, lithium, NSAIDs, tubocurarine, hypoglycaemics.Adverse Reactions
Dizziness, headache, cough, fatigue, hypotension, angioneurotic oedema, nausea, impotence, diarrhoea.Manufacturer
AstraZenecaDrug Availability
(POM)Updated
16 June 2009Advert for Healthcare Professionals Only
Related News
New review of Cryoballoon Ablation treatment for Atrial Fibrillation Cardiology Page
A new research review comparing the efficacy and safety of cryoballoon ablation for Atrial Fibrillation finds that a single cryoballoon ablation procedure for paroxysmal AF results in high acute and medium-term efficacy rates, with lower success rates when used as stand-alone therapy for persistent AF. The rate of complications is relatively low and includes a 6.38% incidence of PNP, most of which is transient. The review also looks at results of the STOP-AF trial, which found that 70 percent of patients with Atrial Fibrillation who were treated with Medtronic's Arctic Fox cryoballoon ablation freezing technique are free of any heart rhythm irregularities one year out from having the procedure. (Heart Rhythm, Volume 8, Issue 9 , Pages 1444-1451, September 2011)
New Drug Eluting Stents safer for PCI patients Cardiology Page
Results from the SCAAR Study, presented at the European Society of Cardiology Congress 2011, showed that Percutaneous Coronary Intervention with "new generation" Drug Eluting Stents (DES), was associated with a 38% lower risk of clinically meaningful restenosis and a 50% lower risk of stent thrombosis compared to old generation DES. The SCAAR study evaluated the long-term outcome in all patients who underwent stent implantation with bare metal stents, "older generation" drug eluting stents, and "new generation" drug eluting stents in Sweden. Further studies are needed to discriminate which component of the new generation DES is involved in decreasing the incidence of stent thrombosis and restenosis.
EMA confirms risk benefit of Multaq Cardiology Page
EMA has confirmed a positive benefit-risk balance for Multaq (dronedarone) from Sanofi- Aventis for the treatment of a newly defined population of paroxysmal and persistent Atrial Fibrillation patients, following its review under the Article 20 procedure. A new indication for Multaq is: indicated for the maintenance of sinus rhythm after successful cardioversion in adult clinically stable patients with paroxysmal or persistent atrial fibrillation.
