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Latest Drugs
Kidney and Urological Diseases Drug Data - A-Z (English)
Drug Class Description
Uroselective a1 -blocker (alpha- blockers / alpha-adrenoceptor blocking drugs).Generic Name
Alfuzosin hydrochlorideDrug Description
White film-coated tablets marked XATRAL 2.5.Presentation
Tablets, alfuzosin hydrochloride 2.5 mg .Indications
Benign prostatic hypertrophy. (BPH)
Adult Dosage
Xatral tablets should be swallowed whole. The first dose should be given just before bedtime.
Adults
The usual dose is one tablet three times daily. The dose may be increased to a maximum of 4 tablets (10mg) per day depending on the clinical response.
Elderly and treated hypertensive patients
As a routine precaution when prescribing alfuzosin to elderly patients (aged over 65 years) and the treated hypertensive patient, the initial dose should be 1 tablet in the morning and 1 tablet in the evening.
Renal insufficiency
In patients with renal insufficiency, as a precaution, it is recommended that the dosing be started at Xatral 2.5mg twice daily adjusted according to clinical response.
Hepatic insufficiency
In patients with mild to moderate hepatic insufficiency, it is recommended that therapy should commence with a single dose of Xatral 2.5mg/day to be increased to Xatral 2.5mg twice daily according to clinical response.
Paediatric population
Efficacy of alfuzosin has not been demonstrated in children aged 2 to 16 years. Therefore, alfuzosin is not indicated for use in the paediatric population.
Child Dosage
Efficacy of alfuzosin has not been demonstrated in children aged 2 to 16 years. Therefore, alfuzosin is not indicated for use in the paediatric population.
Elderly Dosage
As a routine precaution when prescribing alfuzosin to elderly patients (aged over 65 years) and the treated hypertensive patient, the initial dose should be 1 tablet in the morning and 1 tablet in the evening.
Contra Indications
Hypersensitivity to alfuzosin. History of orthostatic hypotension. Co-administration with other alpha-blockers. Severe hepatic insufficiency.Special Precautions
Renal or hepatic impairment. Hypertension; monitor BP regularly, particularly at start of treatment. Coronary insufficiency; discontinue if angina deteriorates. Withdraw 24 hours before anaesthesia.
Interactions
Other a-blockers, antihypertensives. antihypertensives.Adverse Reactions
Faintness, vertigo, dizziness or malaise, headache, GI upset. Orthostatic hypotension, syncope, tachycardia, palpitations, chest pain, fatigue, drowsiness, rash, pruritus, flushes, oedema.
Manufacturer
sanofi-aventisDrug Availability
(POM)Updated
23 November 2011Advert for Healthcare Professionals Only
Related News
Toviaz(Pfizer) success in Overactive Bladder in Older Patients Kidney and Urological Diseases Page
Toviaz (fesoterodine fumarate) from Pfizer has met its primary endpoint in Study A0221049.This was a 12 week trial which enrolled 562 patients aged 65 or older who were randomised to either fesoterodine or placebo. Toviaz was found to be statistically significantly superior to placebo in reducing the mean number of urgency urinary incontinence episodes per day at the end of treatment for Overactive Bladder. While the prevalence of overactive bladder increases with age, limited research has been conducted in older individuals with this condition. Toviaz, a muscarinic antagonist, is approved in both the USA and EU to treat the symptoms of Overactive Bladder.
FDA approves Anturol (Watson Pharma) for Overactive Bladder treatment Kidney and Urological Diseases Page
FDA has approved Anturol (oxybutynin) from Antares Pharma/Watson Pharma as a topical gel 3% for the treatment of Overactive Bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency. The active ingredient is delivered transdermally, and not metabolized by the liver in the same way as orally administered oxybutynin. This results in a low level of side effects, such as dry mouth and constipation. Under an exclusive licensing agreement, Watson anticipates launching the product in 2012.
