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Latest Drugs
Anesthesiology Drug Data - A-Z (English)
Drug Class Description
Long-acting benzodiazepines (anxiolytics).Generic Name
Diazepam - premedicationDrug Description
Valium: 2mg, white tablet; 5mg, yellow tablet. All scored and marked with tablet strength and ROCHE. Valium Injection: ampoules.Presentation
Valium tablets, diazepam 2mg , 5mg . Valium tablets are not prescribable on the NHS. Diazepam tablets must be prescribed generically. Valium injection, diazepam 5mg / mL.Indications
Sedative cover in medical and surgical procedures.Adult Dosage
5-20mg.Child Dosage
2-10mg. See data sheet.Elderly Dosage
2.5-10mg.Contra Indications
Acute pulmonary insufficiency, respiratory depression, phobic or obsessional states, chronic psychosis, myasthenia gravis. Pregnancy, labour and lactation.
Special Precautions
Chronic pulmonary insufficiency, chronic renal or hepatic disease. The elderly. Judgement and dexterity may be impaired, patients should be warned of these effects. Do not use alone to treat depression or anxiety associated with depression. In cases of bereavement, psychological adjustment may be impaired. Avoid long-term use; withdraw gradually.
Interactions
Alcohol and other CNS depressants, anticonvulsants, narcotic analgesics, cimetidine, rifampicin.Adverse Reactions
Drowsiness, light-headedness, muscle weakness, ataxia, hypotension, visual disturbances, skin rashes, impaired alertness and dexterity. Urinary retention, changes in libido. Rarely blood disorders and jaundice. Abnormal psychological reactions, Risk of dependence increases the higher the dose and the longer the treatment.
Manufacturer
RocheDrug Availability
(POM)Updated
27 March 2009Advert for Healthcare Professionals Only
Latest News
13th February 2012
Cyberknife (Accuray Inc) relieves pain of Trigeminal Neuralgia facial nerve condition Page
Cyberknife, the Intensity Modulated RadioTherapy system from Accuray Inc, can relieve the stabbing pain of the facial nerve condition Trigeminal Neuralgia. Researchers treated 17 patients with Trigeminal Neuralgia with Cyberknife radiosurgery between 2007 and 2009. The patients, who were aged between 36 and 90, had had their symptoms for between one and 11 years and had not responded to the available treatment options. The researchers zapped a 6mm length of trigeminal nerve, just 2 to 3mm from the root, using a maximum radiation dose of 73.06 Gy. The patients were then monitored regularly after the procedure, for an average of just under 12 months. Complete data were available for 16 patients, 14 of whom obtained either partial or complete relief from their symptoms. The average time before symptom relief occurred was just under two months, but varied from three weeks to six months. Four patients relapsed after the procedure, between three and 18 months later. No patient experienced major complications as a result of the procedure, and only two patients reported any sensory side effects. See: >"Cyberknife radiosurgery in treating trigeminal neuralgia" by Bryan M Lazzara et al. Journal of NeuroInterventional Surgery (2012). doi:10.1136/neurintsurg-2011-010125
FDA approves trial of Celution System (Cytori Therapeutics) for CMI Cardiology Page
Cytori Therapeutics has received an Investigational Device Exemption (IDE) approval from the FDA to begin the ATHENA trial using its Celution System. ATHENA will investigate the use of the Celution System to treat a form of Coronary Heart Disease, Chronic Myocardial Ischemia (CMI). The IDE application was originally submitted to the FDA in December 2011. The trial will enroll up to 45 patients with no-option CMI who have limited therapeutic options. It will evaluate a variety of clinical and functional outcomes, including safety, peak oxygen consumption (mVO2), and clinical outcomes at 12-months.
Phase III Trial of MDV 3100 (Medivation/Astellas) in Prostate Cancer patients shows positive results Oncology Page
Researchers have presented positive results on all efficacy endpoints from the Phase III AFFIRM trial of the investigational drug MDV 3100, from Medivation and Astellas, in men with Prostate Cancer previously treated with chemotherapy. The results, presented at the 2012 Genitourinary Cancers Symposium, show that men taking MDV 3100 lived for a median of 18.4 months, compared with 13.6 months for men taking placebo. MDV 3100 also met all secondary endpoints, including radiographic progression-free survival (8.3 versus 2.9 months; PSA declines of 50% or greater were more common in the MDV 3100 group than in the placebo group (54.0% versus 1.5%; and MDV 3100 was found to be well tolerated. The data was presented by Howard I. Scher, chief, Genitourinary Oncology Service at Memorial-Sloan Kettering Cancer Center.
