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Latest Drugs
- GARAMYCIN®, INJEKTIONSVÄTSKA OCH INFUSIONSKONCENTRAT 80 MG/ML, SCHERING-PLOUGH AB
- SYNAGIS™, INJEKTIONSSUBSTANS I+II 100 MG, ABBOTT SCANDINAVIA AB
- BERIGLOBIN®, INJEKTIONSVÄTSKA, LÖSNING 160 MG/ML, AVENTIS BEHRING AB
- CLINDAMYCIN RATIOPHARM®, INJEKTIONS-/INFUSIONSVÄTSKA, LÖSNING 150 MG/ML, RATIOPHARM AB
Infectious Diseases Drug Data - A-Z (Svenska)
Drug Description
1 dosgranulat innehåller: Erythromycin. ethylsuccin. respond. erythromycin. 200 mg, mannitol. 1,5 g, constit. et aroma q. s.Presentation
Dosgranulat 200 mgIndications
Pneumoni orsakad av Mycoplasma pneumoniae, Chlamydia psittaci (ornitos) eller Chlamydia pneumoniae (TWAR). Kikhosta. Difteri. Urogenitala infektioner orsakade av Chlamydia trachomatis. Konjunktivit och pneumoni hos nyfödda orsakade av Chlamydia trachomatis.Vid följande indikationer bör ABBOTICIN förbehållas patienter med penicillinöverkänslighet eller där penicillin är olämpligt av andra skäl: Faryngotonsillit. Akut otitis media. Samhällsförvärvad pneumoni. Hud- och mjukdelsinfektioner.
Adult Dosage
Dosen för barn beräknas efter 30—50 mg per kg kroppsvikt och dygn fördelat på 2—4 doseringstillfällen. 1 dosgranulat=200 mg erytromycin. För barn upp till 4 kg beräknas dosen i det enskilda fallet. Vid kroppsvikt överstigande 4 kg kan om dygnsdosen fördelas på två doseringstillfällen följande schema vanligen tillämpas:- - Dygns- - - Lämplig
- - dosering - - förpackning för 10
- Vikt kg - dosgranulat - mg/kg/dygn - dagars behandling
- 4— 7 - ½×2 - 50—29 - 1×30
- 8—14 - 1×2 - 50—29 - 1×30
- 15—24 - 2×2 - 53—33 - 2×30
- 25—34 - 3×2 - 48—35 - 2×30
Inträffar gastrointestinala problem rekommenderas uppdelning av dygnsdosen på 3 eller 4 administreringstillfällen. För vuxna och barn över 35 kg ges 3 dosgranulat 3 gånger per dygn. Optimal absorption erhålles om dosen intages omedelbart före måltid.
Behandlingskontroll
Speciellt vid långtidsbehandling eller upprepad terapi kan överväxt av icke känsliga bakterier eller svampar inträffa. Erytromycin skall då utsättas och lämplig terapi inledas.
Contra Indications
Känd överkänslighet för makrolider. Samtidig medicinering med terfenadin eller cisaprid.Special Precautions
Eftersom erytromycin huvudsakligen utsöndras via levern skall försiktighet iakttas vid administrering till patienter med nedsatt leverfunktion.Det finns rapporter om att erytromycin kan förvärra symptomen hos Myasthenia gravis-patienter.
Interactions
Kombination med terfenadin bör undvikas, D.Följande kombinationer med ABBOTICIN kan kräva dosanpassning, C: alfentanil, alprazolam, bromokriptin, ciklosporin, cimetidin, dihydroergotamin, disopyramid, ergotamin, karbamazepin, klozapin, metylprednisolon, midazolam, takrolimus, teofyllin, triazolam, warfarin och zopiklon.
Se speciellt avsnitt märkt , J01F A01 Erytromycin.
Erytromycin interagerar med metabolismen av fenytoin, vilket kan resultera i ökade plasmakoncentrationer av fenytoin.
Förhöjda cisapridnivåer har rapporterats hos patienter som fått erytromycin och cisaprid samtidigt. Detta kan resultera i förlängt QT-intervall och hjärtarytmier inkluderande ventrikulär takykardi, ventrikelflimmer och torsade de pointes.
Adverse Reactions
Gastrointestinala besvär uppträder i 10—15% av fallen. De är dosberoende och kan upphöra under behandlingen.- Vanliga (>1/100) - GI: Magknip, illamående, diarré. Hud: Utslag.
- Mindre vanliga (1/100 - 1/1000) - Hud: Urtikaria.
- Sällsynta (< 1/1000) - Allmänna: Anafylaxi. Cirk.: Arytmi. GI: Pseudomembranös kolit. Lever: Förhöjda leverenzymvärden, bilirubinstegring, intrahepatisk gallstas. Öron: Reversibel hörselförlust.
För att minska eventuella gastrointestinala besvär bör ABBOTICIN intagas omedelbart före måltid.
Erytema multiforme, Stevens-Johnsons syndrom och toxisk epidermal nekrolys har rapporterats i enstaka fall.
Manufacturer
Abbott Scandinavia ABAdvert for Healthcare Professionals Only
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