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Latest Drugs
Central Nervous System Drug Data - A-Z (English)
Drug Class Description
Antihistamines (sedating).Generic Name
DiphenhydramineDrug Description
Nytol contains 25mg Diphenhydramine Hydrochloride BP per tablet.Presentation
Tablets to be taken orally.Indications
An aid to the relief of temporary sleep disturbance.
Adult Dosage
Two tablets to be taken 20 minutes before going to bed, or as directed by a physician.
Not recommended for children under 16 years.
Child Dosage
Not recommended.Contra Indications
Nytol is contraindicated in patients who are hypersensitive to diphenhydramine and in those with the following conditions: asthma, narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction or bladder neck obstruction.
Special Precautions
Nytol should be used with caution in patients with myasthenia gravis or seizure disorders. Tolerance may develop with continuous use.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Interactions
Diphenhydramine has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquillizers). Monoamine oxidase (MAO) inhibitors prolong and intensify the anticholinergic effects of Diphenhydramine.
Diphenhydramine should not be used in patients receiving one of these drugs unless directed by a doctor.
Adverse Reactions
Dizziness, drowsiness and grogginess are the undesirable effects most frequently reported by Nytol users. The frequency of these are approximately 6%, 4.5% and 7% respectively. These effects are mild and wear off about 8 hours after taking the medication. Dryness of mouth, nausea and nervousness have also been reported with diphenhydramine. The antihistamines have been reported rarely to cause thrombocytopenia.
Manufacturer
GlaxoSmithKline Consumer HealthcareDrug Availability
(P)Updated
29 June 2009Advert for Healthcare Professionals Only
Related News
TEMSO study for Aubagio in Multiple Sclerosis is published in NEJM Central Nervous System Page
The pivotal Phase III TEMSO study with investigational once-daily oral medication Aubagio (teriflunomide) from Sanofi/Genzyme is published in The New England Journal of Medicine (NEJM). Results showed that teriflunomide at the 14mg dosage significantly reduced the annual relapse rate, reduced disability progressions and improved several magnetic resonance imaging (MRI) measures of disease activity, including new or worsening brain lesions in relapsing, remitting Multiple Sclerosis. Teriflunomide has a well-characterized safety profile, with a similar proportion of trial participants reporting adverse events compared to placebo. Teriflunomide has been filed with the FDA in August of 2011 and the EMA filing is expected in the first quarter of 2012. see Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis Paul O'Connor, M.D., et al for the TEMSO Trial Group N Engl J Med 2011; 365:1293-1303 October 6, 2011.
Tysabri shows benefits in Multiple Sclerosis patients Central Nervous System Page
Patients with Multiple Sclerosis who take anti-inflammatory Tysabri (natalizumab), from Biogen and Elan, for two years showed a reduced risk of experiencing at least one relapse (at 2 years this was reduced by 40%). The study also showed that the number of patients whose disability progressed in the time interval was reduced by 25%. In addition, MRI scans showed evidence that treatment with Tysabri reduced disease activity. Treatment also created some side effects including limb swelling, rigors, vaginal inflammation and menstrual disorders and 2 patients treated with Tysabri for more than 2 years developed Progressive Multifocal Leukoencephalopathy, a rare and often fatal viral disease. In light of this, the researchers recommend further studies. The review was published in The Cochrane Database of Systematic Reviews: "Natalizumab for relapsing remitting multiple sclerosis" by Eugenio Pucci et al. Issue 105 OCT 2011.Tysabri is approved in the USA and EU.
Lemtrada and Aubagio trials to report at ECTRIMS/ACTRIMS congress Central Nervous System Page
Genzyme/Sanofi will report more than 20 abstracts at ECTRIMS/ACTRIMS congress. Data will include Phase III results of Lemtrada(alemutuzumab) and Aubagio ( oral teriflunomide) in relapsing remitting Multiple Sclerosis (MS) including CARE-MS 1 study comparing Lemtrada and Rebif (interferon beta 1-a) in relapsing remitting MS and five year extension of TEMSO study of oral Aubagio (Poster 924) and efficacy of Aubagio (Poster 438) and long term results for Lemtrada CARE-MS Phase II trial (Poster 928) and four year efficacy of Lemtrada in MS (Poster 931). Lemtrada is being developed by Genzyme/Sanofi in the USA and Bayer HealthCare in the EU.
