07 Jan 2001

Rovamycine (spiramycine) - Nederland

Updated: 07 Jan 2001

Rovamycine

Luchtweginfecties door voor spiramycine gevoelige micro- organismen.

Rovamycine Description, Presentation and Dosage

Rovamycine Description

Rovamycine Drug Class Description

Volwassenen: eerste dag 1500 mg tweemaal per dag; volgende dagen 1 g tweemaal per dag. Kinderen: 50-100 mg/kg lichaamsgewicht per dag in 2-4 doses.

Rovamycine Drug Description

Bacteriostatisch antibioticum. Het spectrum omvat o.a. streptokokken en stafylokokken en de Gram-negatieve organismen Haemophilus influenza, Neisseria gonorrhoeae en meningitidis en Bordetella pertussis. Spiramycine ontplooit de grootste werkzaamheid in alkalisch milieu. Kinetische gegevens: Resorptie: onvolledig, vooral bij kinderen. Tmax = ca 2 uur. Penetreert goed in de weefsels; deze concentraties kunnen meer dan tienmaal zo hoog zijn als de bloedspiegels. Passeert de bloed- hersenbarriere niet. Eliminatie: vnl. via speeksel en gal; via de urine max. 10%. Plasmahalfwaardetijd = 3-4 uur.

Rovamycine Generic Name

spiramycine

Rovamycine Presentation

Rovamycine Presentation

Tablet 500 mg.

Rovamycine Manufacturer

RPR

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Rovamycine Dosage

Rovamycine Child Dosage

Spiramycine kan, voor zover bekend zonder gevaar voor de vrucht, overeenkomstig het voorschrift worden gebruikt tijdens zwangerschap.

Rovamycine Precautions, Reactions and Contraindications

Rovamycine Special Precautions

Rovamycine Special Precautions

Er bestaat kruisresistentie tussen de macroliden onderling en met antimicrobiele middelen van de lincomycinengroep.

Rovamycine Adverse Reactions

Rovamycine Adverse Reactions

Lichte gastro-intestinale stoornissen, exanthemen. Overgevoeligheid kan voorkomen.

Rovamycine Contraindications

Rovamycine Contraindications

Overgevoeligheid voor macroliden.

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