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Latest Drugs
Nutrition and Dietetics Drug Data - A-Z (English)
Drug Class Description
Mineral supplements (minerals).Generic Name
GenericDrug Description
Magnesium Sulphate BP 50% w/vPresentation
Sterile solution for parenteral use.Indications
Treatment of magnesium deficiency where the oral route of administration may be inappropriate, which may be due to malabsorption syndromes, chronic alcoholism, malnutrition, severe diarrhoea or patients on total parenteral nutrition.Adult Dosage
Magnesium sulphate injection may be administered by intramuscular or intravenous routes. For intravenous administration, a concentration of 20% or less should be used; the rate of injection not exceeding 1.5ml/minute of a 10% solution or its equivalent.
Adults
The dosage should be individualised according to patient's needs and responses.
Mild magnesium deficiency
1g intramuscularly every 6 hours for 4 doses.
Severe magnesium deficiency
Up to 250mg/kg intramuscularly given over 4 hours or 5g/litre of infusion solution intravenously over 3 hours.
Elderly Dosage
It is recommended that the solution be diluted to 20% w/v prior to intramuscular injection.
Contra Indications
Magnesium sulphate is contraindicated in patients with heart block, myocardial damage or impaired renal function.
Special Precautions
Magnesium sulphate must be used with caution in patients suspected of or known to have renal impairment
Interactions
Administer with caution to patients receiving digitalis glycosides. Effects of neuromuscular blocking agents may be enhanced. Magnesium sulphate should not be administered concomitantly with high doses of barbiturates, opioids or hypnotics due to the risk of respiratory depression.
Concomitant use of nifedipine may very rarely lead to a calcium ion imbalance and could result in abnormal muscle function.
Adverse Reactions
Hypermagnesaemia characterised by flushing, thirst, hypotension, drowsiness, nausea, vomiting, confusion, loss of tendon reflexes due to neuromuscular blockade, muscle weakness, respiratory depression, cardiac arrhythmias, coma and cardiac arrest.
There is a risk of respiratory depression if magnesium sulphate is administered concomitantly with high doses of barbiturates, opioids or hypnotics
Manufacturer
UCB Pharma LimitedDrug Availability
(POM)Updated
02 June 2009Advert for Healthcare Professionals Only
Latest News
12th February 2012
Cyberknife (Accuray Inc) relieves pain of Trigeminal Neuralgia facial nerve condition Page
Cyberknife, the Intensity Modulated RadioTherapy system from Accuray Inc, can relieve the stabbing pain of the facial nerve condition Trigeminal Neuralgia. Researchers treated 17 patients with Trigeminal Neuralgia with Cyberknife radiosurgery between 2007 and 2009. The patients, who were aged between 36 and 90, had had their symptoms for between one and 11 years and had not responded to the available treatment options. The researchers zapped a 6mm length of trigeminal nerve, just 2 to 3mm from the root, using a maximum radiation dose of 73.06 Gy. The patients were then monitored regularly after the procedure, for an average of just under 12 months. Complete data were available for 16 patients, 14 of whom obtained either partial or complete relief from their symptoms. The average time before symptom relief occurred was just under two months, but varied from three weeks to six months. Four patients relapsed after the procedure, between three and 18 months later. No patient experienced major complications as a result of the procedure, and only two patients reported any sensory side effects. See: >"Cyberknife radiosurgery in treating trigeminal neuralgia" by Bryan M Lazzara et al. Journal of NeuroInterventional Surgery (2012). doi:10.1136/neurintsurg-2011-010125
FDA approves trial of Celution System (Cytori Therapeutics) for CMI Cardiology Page
Cytori Therapeutics has received an Investigational Device Exemption (IDE) approval from the FDA to begin the ATHENA trial using its Celution System. ATHENA will investigate the use of the Celution System to treat a form of Coronary Heart Disease, Chronic Myocardial Ischemia (CMI). The IDE application was originally submitted to the FDA in December 2011. The trial will enroll up to 45 patients with no-option CMI who have limited therapeutic options. It will evaluate a variety of clinical and functional outcomes, including safety, peak oxygen consumption (mVO2), and clinical outcomes at 12-months.
Phase III Trial of MDV 3100 (Medivation/Astellas) in Prostate Cancer patients shows positive results Oncology Page
Researchers have presented positive results on all efficacy endpoints from the Phase III AFFIRM trial of the investigational drug MDV 3100, from Medivation and Astellas, in men with Prostate Cancer previously treated with chemotherapy. The results, presented at the 2012 Genitourinary Cancers Symposium, show that men taking MDV 3100 lived for a median of 18.4 months, compared with 13.6 months for men taking placebo. MDV 3100 also met all secondary endpoints, including radiographic progression-free survival (8.3 versus 2.9 months; PSA declines of 50% or greater were more common in the MDV 3100 group than in the placebo group (54.0% versus 1.5%; and MDV 3100 was found to be well tolerated. The data was presented by Howard I. Scher, chief, Genitourinary Oncology Service at Memorial-Sloan Kettering Cancer Center.
