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Latest Drugs
Cardiology Drug Data - A-Z (English)
Drug Class Description
Loop diuretics / K+-sparing diuretics (potassium-sparing diuretics).Generic Name
Frusemide [furosemide], amiloride [co-amilofruse]Drug Description
Yellow tablets.Presentation
Tablets, frusemide (furosemide) 40mg, amiloride hydrochloride 5mg.Indications
Prompt diuresis where potassium conservation is important.Adult Dosage
1 - 2 in the morning.
Child Dosage
Not recommended.Elderly Dosage
Adjust dose according to renal function, response and electrolyte levels.Contra Indications
Severe or progressive renal failure. Precomatose states associated with liver cirrhosis. Hyperkalaemia, Addison's disease, electrolyte imbalance.Special Precautions
Prostatic hypertrophy, impaired micturition, diabetes, gout. Elderly. Pregnancy, lactation. Monitor fluid and electrolyte levels regularly.Interactions
K+ supplements and K+-sparing diuretics (avoid). Lithium, nephrotoxic or ototoxic antibiotics, NSAIDs, digitalis, antihypertensives, antidiabetic agents, non-depolarising muscle relaxants.
Adverse Reactions
Malaise, GI disturbances, pruritus. Blood dyscrasias (withdraw). Reduced alertness, calcium depletion. Rarely minor psychiatric disturbances, altered liver function tests, ototoxicity, pancreatitis.
Manufacturer
BorgDrug Availability
(POM)Updated
18 May 2009Advert for Healthcare Professionals Only
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A new research review comparing the efficacy and safety of cryoballoon ablation for Atrial Fibrillation finds that a single cryoballoon ablation procedure for paroxysmal AF results in high acute and medium-term efficacy rates, with lower success rates when used as stand-alone therapy for persistent AF. The rate of complications is relatively low and includes a 6.38% incidence of PNP, most of which is transient. The review also looks at results of the STOP-AF trial, which found that 70 percent of patients with Atrial Fibrillation who were treated with Medtronic's Arctic Fox cryoballoon ablation freezing technique are free of any heart rhythm irregularities one year out from having the procedure. (Heart Rhythm, Volume 8, Issue 9 , Pages 1444-1451, September 2011)
New Drug Eluting Stents safer for PCI patients Cardiology Page
Results from the SCAAR Study, presented at the European Society of Cardiology Congress 2011, showed that Percutaneous Coronary Intervention with "new generation" Drug Eluting Stents (DES), was associated with a 38% lower risk of clinically meaningful restenosis and a 50% lower risk of stent thrombosis compared to old generation DES. The SCAAR study evaluated the long-term outcome in all patients who underwent stent implantation with bare metal stents, "older generation" drug eluting stents, and "new generation" drug eluting stents in Sweden. Further studies are needed to discriminate which component of the new generation DES is involved in decreasing the incidence of stent thrombosis and restenosis.
EMA confirms risk benefit of Multaq Cardiology Page
EMA has confirmed a positive benefit-risk balance for Multaq (dronedarone) from Sanofi- Aventis for the treatment of a newly defined population of paroxysmal and persistent Atrial Fibrillation patients, following its review under the Article 20 procedure. A new indication for Multaq is: indicated for the maintenance of sinus rhythm after successful cardioversion in adult clinically stable patients with paroxysmal or persistent atrial fibrillation.
