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Latest Drugs
Cardiology Drug Data - A-Z (English)
Drug Class Description
a/b-blockers (alpha-blockers / beta-blockers).Generic Name
GenericDrug Description
Tablets, film-coated.Presentation
Tablets, labetalol hydrochloride 100 mg , 200 mg , 400 mg . Available from Cox, Generics UK, Hillcross, Lagap.Indications
Hypertension
Adult Dosage
Initially, 100mg twice daily with Initially, 100mg twice daily with food, increasing if necessary at two-week intervals to a maximum dose of 2.4g daily in three or four divided doses.
Elderly Dosage
Initially, 50mg twice daily.Contra Indications
2nd or 3rd degree AV block, sinus bradycardia, sick sinus syndrome, severe peripheral arterial disease, uncompensated cardiac failure, cardiogenic shock, hypotension, right ventricular failure secondary to pulmonary hypertension, significant cardiomegaly, untreated phaeochromocytoma.
Special Precautions
Poor cardiac reserve should be controlled with digitalis and diuretics. History of bronchospasm (labetalol usually has a lesser effect on airways resistance than the non-selective type but should be avoided in patients with wheezing or obstrucive airways disease unless there are compelling clinical reasons).
Diabetes: metabolic acidosis. Asthenic symptoms. Cerebrovascular insufficiency. Atopy. Renal or hepatic impairment, thyrotoxic crisis. General anaesthesia; consider withdrawal before elective surgery. Pregnancy and lactation. Withdraw gradually.
Interactions
Clonidine withdrawal, verapamil, diltiazem, class II calcium- channel blockers, class I antiarrhythmics, cardiac depressant anaesthetics, hypoglycaemics, reserpine, other antihypertensives, ergot alkaloids, cimetidine, rifampicin, theophylline, warfarin, CNS depressants, sympathominetics, indometacin (indomethacin).
Adverse Reactions
Dizziness, headache, fatigue, oedema, ejaculatory fialure, nasal congestion. Rarely, postural hypotension, hepatic reaction. Cold extremities, sleep disturbances (particularly with the more lipophilic drugs), tiredness, bronchospasm, heart failure, hypotension, gastrointestinal upset. If unexplained dry eyes or skin rash occur withdraw gradually.
Drug Availability
(POM)Updated
31 August 2010Advert for Healthcare Professionals Only
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