Drug Class Description

Generic Name

Drug Description

Presentation

Indications

Adult Dosage

Adults, children and the elderly:

With subcutaneous infusion (hypodermoclysis): 1500iu of Hyalase® dissolved in 1ml of water for injections or normal saline injected into the site, before the infusion is set up, or injected into the tubing of the infusion set, about 2cm back from the needle, at the start of the infusion. 1500iu is sufficient for administration of 500-1000ml of most fluids. Refer to Section 4.4 for information on solutions for hypodermoclysis. Care should be taken in young children and the elderly to control the speed and total volume of fluid administered and to avoid over-hydration, especially in renal impairment.

With subcutaneous or intramuscular injections: 1500iu of Hyalase® dissolved directly in the solution to be injected.

With local anaesthetics: 1500iu Hyalase® is mixed with the quantity of local anaesthetic solution to be used. In ophthalmology, 15iu of Hyalase® per ml is recommended.

Extravasation: Where dispersal rather than localisation is indicated, 1500iu of Hyalase® in 1ml water for injections or normal saline infiltrated into the affected area as soon as possible after the extravasation is noted.

Haematoma: 1500iu of Hyalase® dissolved in 1ml water for injections or normal saline infiltrated into the affected area.

Immediately before use dissolve the freeze-dried powder in approximately 1ml of water for injections or directly in the solution with which Hyalase® is to be combined.

Contra Indications

Hypersensitivity to hyaluronidase

Not to be used to reduce the swelling of bites or stings or at sites where infection or malignancy is present. Not to be used for anaesthetic procedures in cases of unexplained premature labour.

Special Precautions

Do not apply directly to the cornea.

Not to be used for intravenous injections.

Solutions for subcutaneous administration should be isotonic with extracellular fluid. Hyalase® is physically compatible with the commonly used infusion fluids. Use in hypodermoclysis has been reported with 0.9% sodium chloride, 0.18% sodium chloride with 4% glucose, 0.45% sodium chloride with 2.5% glucose and 5% glucose.

Potassium 34mmol/litre has been administered in isotonic glucose or saline.

Electrolyte-free fluids are less preferable than those containing electrolytes and should not be given too rapidly. Hyalase® has also been mixed with morphine, diamorphine, hydromorphone, chlorpromazine, metoclopramide, promazine, dexamethasone, local anaesthetics and adrenaline.

Adverse Reactions

Oedema has been reported in association with hypodermoclysis. Allergic reactions have included rare reports of periorbital oedema occurring with the use of hyaluronidase in conjunction with local anaesthetics in ophthalmology.Severe allergic reactions including anaphylaxis have been reported rarely. Local irritation, infection, bleeding and bruising occur rarely.

Manufacturer

Drug Availability

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