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Gastroenterology Drug Data - A-Z (English)
Drug Class Description
Proton pump inhibitors (PPIs) / macrolides / broad spectrum penicillins (antibiotics).Generic Name
Lansoprazole, clarithromycin, amoxicillin [amoxycillin]Drug Description
Zoton Capsules: lilac/purple capsules marked with strength and company name. Klaricid Tablets: yellow oval f-c tablets with logo. Amoxycillin Capsules: capsules.Presentation
Treatment pack containing 14 Zoton (lansoprazole) capsules, 14 Klaricid (clarithromycin) 500mg tablets, 28 amoxicillin 500mg capsules.Indications
Eradication of Helicobacter pylori in patients with duodenal ulcersAdult Dosage
1 x Zoton capsule, 1 x Klaricid tablet and 2 x amoxycillin capsules all twice daily for seven days.Child Dosage
Not recommendedContra Indications
Severe renal impairment. PregnacySpecial Precautions
Exclude malignacy pror to treatment. Renal or hepatic treatment. Renal or hepatic impairment. LactationInteractions
Drugs metabolised by cytochrome P450 system (eg, warfarin, ergot alkaloids, triazolam, midazolam, disopyramide, lovastatin, rifabutin, phenytoin and cyclosporin). Rhabdomyolysis, coincident with the co- administration of clarithromycin, and HMG-CoA reductase inhibitors, such as lovastatin and simvastatin has been reported.
Theophylline, oral anticoagulants, digoxin, carbamazepine, ritonavir, zidovudine, statins, phenytoin, antacids, sulcrafate, oral contraceptives.
Adverse Reactions
Amoxycillin : GI upset, hypersensitivity reactions. Clarithromycin : GI upset, paraesthesia, stomatitis, glossitis, oral monilia, tongue and tooth discolouration, headache, arthralgia, myalgia, and allergic reactions ranging from urticaria and mild skin eruptions and angioedema to anapyhlaxis and rarely Stevens- Johnson syndrome.
Hepatic dysfunction, reversible hearing loss. Rarely, pseudomembranous colitis, hypoglycaemia, leucopenia, thrombocytopenia, renal dysfunction, interstitial nephritis, and renal failure. QT prolongation, ventricular tachycardia and Torsades de Pointes have been reported rarely.
Lansoprazole: Headache, dizziness, fatigue, malaise, GI upset, sore throat, skin irritation, hypersensitivity reactions, raised liver function values, jaundice, hepatitis, increased risk of GI infections. Rarely arthralgia, myalgia, peripheral oedema, haematological changes, erythmatous or bullous rashes, photosensitivity, interstitial nephritis, confusion, hallucinations, gynaecomastia, impotence.
Manufacturer
WyethDrug Availability
(POM)Updated
14 May 2009Advert for Healthcare Professionals Only
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